AIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)4.26290140
2DNA deamination (GO:0045006)4.22898515
3positive thymic T cell selection (GO:0045059)4.12500781
4positive regulation of B cell differentiation (GO:0045579)3.88283832
5NIK/NF-kappaB signaling (GO:0038061)3.81625674
6thymic T cell selection (GO:0045061)3.64927941
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.61621548
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.60907828
9positive T cell selection (GO:0043368)3.57212234
10ribosomal small subunit assembly (GO:0000028)3.54387738
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48823719
12negative regulation of cell killing (GO:0031342)3.48823719
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42135449
14positive regulation of gamma-delta T cell activation (GO:0046645)3.38845690
15GDP-mannose metabolic process (GO:0019673)3.35653993
16T cell selection (GO:0045058)3.34736301
17B cell receptor signaling pathway (GO:0050853)3.30452320
18protein deneddylation (GO:0000338)3.29190185
19T cell migration (GO:0072678)3.27974055
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27864741
21antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27312894
22cullin deneddylation (GO:0010388)3.25686945
23B cell mediated immunity (GO:0019724)3.19682044
24mast cell activation (GO:0045576)3.18616732
25regulation of gamma-delta T cell differentiation (GO:0045586)3.17209403
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16890642
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16890642
28cytidine deamination (GO:0009972)3.15377584
29cytidine metabolic process (GO:0046087)3.15377584
30cytidine catabolic process (GO:0006216)3.15377584
31response to interferon-beta (GO:0035456)3.14401764
32antigen processing and presentation of endogenous antigen (GO:0019883)3.13845384
33regulation of gamma-delta T cell activation (GO:0046643)3.13803544
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12229132
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09912593
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03847971
37purine deoxyribonucleotide catabolic process (GO:0009155)3.01557624
38cellular response to zinc ion (GO:0071294)2.97932091
39regulation of alpha-beta T cell proliferation (GO:0046640)2.97789527
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97498494
41negative regulation of ligase activity (GO:0051352)2.97252750
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97252750
43detection of bacterium (GO:0016045)2.97105106
44negative regulation of B cell apoptotic process (GO:0002903)2.96930072
45neutrophil activation involved in immune response (GO:0002283)2.95234492
46protein complex biogenesis (GO:0070271)2.93581283
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91220736
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91220736
49positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90980404
50protein neddylation (GO:0045116)2.90267709
51actin nucleation (GO:0045010)2.89597997
52chaperone mediated protein folding requiring cofactor (GO:0051085)2.88688890
53regulation of T cell mediated cytotoxicity (GO:0001914)2.87477283
54regulation of B cell receptor signaling pathway (GO:0050855)2.87232788
55cellular response to interferon-beta (GO:0035458)2.86197257
56proteasome assembly (GO:0043248)2.85683610
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85052836
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85052836
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85052836
60leukocyte aggregation (GO:0070486)2.83965010
61regulation of cellular amino acid metabolic process (GO:0006521)2.83917593
62negative thymic T cell selection (GO:0045060)2.82490509
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81155906
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81155906
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.81155906
66modulation by symbiont of host immune response (GO:0052553)2.81155906
67positive regulation by symbiont of host defense response (GO:0052509)2.81155906
68modulation by symbiont of host defense response (GO:0052031)2.81155906
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80992579
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.80992579
71NADH dehydrogenase complex assembly (GO:0010257)2.80992579
72chaperone-mediated protein transport (GO:0072321)2.79826873
73barbed-end actin filament capping (GO:0051016)2.78357256
74immunoglobulin mediated immune response (GO:0016064)2.78050288
75myeloid dendritic cell activation (GO:0001773)2.77928546
76positive regulation of alpha-beta T cell proliferation (GO:0046641)2.77063213
77negative T cell selection (GO:0043383)2.76263910
78respiratory chain complex IV assembly (GO:0008535)2.76199856
79detection of other organism (GO:0098543)2.75928936
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74405330
81response to interleukin-15 (GO:0070672)2.74216780
82myeloid dendritic cell differentiation (GO:0043011)2.72213383
83type I interferon signaling pathway (GO:0060337)2.71734616
84cellular response to type I interferon (GO:0071357)2.71734616
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71473565
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.71473565
87cytochrome complex assembly (GO:0017004)2.71045593
88antigen receptor-mediated signaling pathway (GO:0050851)2.70921483
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70387615
90regulation of protein heterodimerization activity (GO:0043497)2.70327027
91positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69479441
92mitochondrial respiratory chain complex assembly (GO:0033108)2.69363726
93regulation of relaxation of muscle (GO:1901077)2.68822485
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.68767651
95negative regulation of interleukin-12 production (GO:0032695)2.66400264
96response to type I interferon (GO:0034340)2.66356636
97purine-containing compound salvage (GO:0043101)2.65460724
98regulation of defense response to virus by virus (GO:0050690)2.65416505
99positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64339063
100cellular response to interleukin-15 (GO:0071350)2.64141365
101negative regulation of erythrocyte differentiation (GO:0045647)2.64114491
102negative regulation of phagocytosis (GO:0050765)2.63911955
103signal transduction involved in cell cycle checkpoint (GO:0072395)2.63654338
104regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63152764
105regulation of natural killer cell mediated immunity (GO:0002715)2.63152764
106positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.63052896
107regulation of interleukin-2 biosynthetic process (GO:0045076)2.62989692
108oxidative phosphorylation (GO:0006119)2.61884345
109formation of translation preinitiation complex (GO:0001731)2.61865878
110defense response to protozoan (GO:0042832)2.61412231
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60453123
112GMP metabolic process (GO:0046037)2.59202184
113phagosome maturation (GO:0090382)2.58979885
114purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.58110712
115negative regulation of leukocyte mediated immunity (GO:0002704)2.57500944
116endosome to melanosome transport (GO:0035646)2.56821716
117endosome to pigment granule transport (GO:0043485)2.56821716
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56746388
119viral transcription (GO:0019083)2.56642007
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56605702
121antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.55750399
122regulation of antigen processing and presentation (GO:0002577)2.55571703
123T cell receptor signaling pathway (GO:0050852)2.55005877
124positive regulation of isotype switching (GO:0045830)2.54936304
125regulation of T cell tolerance induction (GO:0002664)2.54734703
126negative regulation of myeloid cell apoptotic process (GO:0033033)2.54656591
127T cell costimulation (GO:0031295)2.54593378
128antigen processing and presentation via MHC class Ib (GO:0002475)2.53983740
129positive regulation of granulocyte differentiation (GO:0030854)2.53974756
130deoxyribonucleotide catabolic process (GO:0009264)2.53703945
131interferon-gamma-mediated signaling pathway (GO:0060333)2.53288574
132NADH metabolic process (GO:0006734)2.52706575
133lymphocyte migration (GO:0072676)2.52644949
134regulation of B cell apoptotic process (GO:0002902)2.51420538
135respiratory burst (GO:0045730)2.51239520
136lymphocyte costimulation (GO:0031294)2.51174520
137purine nucleotide salvage (GO:0032261)2.50296496
138purine deoxyribonucleotide metabolic process (GO:0009151)2.50126919
139regulation of isotype switching to IgG isotypes (GO:0048302)2.49910400
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49662957
141negative regulation of innate immune response (GO:0045824)2.49438761
142positive regulation of cell killing (GO:0031343)2.48129170
143deoxyribose phosphate catabolic process (GO:0046386)2.47647865
144cellular response to interleukin-4 (GO:0071353)2.47139378
145response to protozoan (GO:0001562)2.47101502
146negative regulation of T cell mediated immunity (GO:0002710)2.46986547
147Peyers patch development (GO:0048541)2.46782149
148mucosal-associated lymphoid tissue development (GO:0048537)2.46782149
149positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.46508787
150platelet dense granule organization (GO:0060155)2.43826558
151transferrin transport (GO:0033572)2.43708749
152mast cell degranulation (GO:0043303)2.42611347
153mast cell activation involved in immune response (GO:0002279)2.42611347
154translational elongation (GO:0006414)2.41537304
155translational termination (GO:0006415)2.41513277
156de novo posttranslational protein folding (GO:0051084)2.41438134
157regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.39361169
158mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.39208502
159regulation of B cell differentiation (GO:0045577)2.39140421
160mature B cell differentiation involved in immune response (GO:0002313)2.38872538
161iron-sulfur cluster assembly (GO:0016226)2.38424274
162metallo-sulfur cluster assembly (GO:0031163)2.38424274
163positive regulation of cell cycle arrest (GO:0071158)2.38055040
164telomere maintenance via semi-conservative replication (GO:0032201)2.37583380
165positive regulation of lamellipodium assembly (GO:0010592)2.37519086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98596885
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.94468153
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02150948
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.88145169
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.87110224
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.83114658
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71454683
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66127045
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.65331162
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.64516299
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61942427
12* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.60817673
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60337513
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58554616
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55946956
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54873089
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47717248
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39827098
19VDR_21846776_ChIP-Seq_THP-1_Human2.23945317
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06295986
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04236211
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.03275644
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02338635
24VDR_23849224_ChIP-Seq_CD4+_Human1.98032237
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.97171684
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97010504
27MYC_22102868_ChIP-Seq_BL_Human1.96992630
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95457819
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.91182509
30* SPI1_23547873_ChIP-Seq_NB4_Human1.90386197
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87865896
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87084132
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86045158
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.84505341
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82737484
36* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79969385
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73648514
38* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70145240
39* GABP_19822575_ChIP-Seq_HepG2_Human1.66808003
40XRN2_22483619_ChIP-Seq_HELA_Human1.66727579
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66399714
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64658094
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64454771
44FOXP3_21729870_ChIP-Seq_TREG_Human1.63030760
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62026049
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61803569
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60591018
48DCP1A_22483619_ChIP-Seq_HELA_Human1.55838405
49* MAF_26560356_Chip-Seq_TH1_Human1.53994927
50CIITA_25753668_ChIP-Seq_RAJI_Human1.53146689
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52534334
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52439184
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47323237
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46571891
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46548182
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45726960
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45606252
58* MYB_26560356_Chip-Seq_TH2_Human1.44431472
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44305777
60* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.42616702
61VDR_24763502_ChIP-Seq_THP-1_Human1.42448548
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40898618
63BCL6_27268052_Chip-Seq_Bcells_Human1.40247850
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38504307
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37849330
66SCL_19346495_ChIP-Seq_HPC-7_Human1.37414070
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.36909307
68BCOR_27268052_Chip-Seq_Bcells_Human1.35790564
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35206972
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34396009
71MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33666201
72* UTX_26944678_Chip-Seq_JUKART_Human1.33197507
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32438270
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31088518
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30153362
76* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30060427
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30047168
78P68_20966046_ChIP-Seq_HELA_Human1.29693679
79MAF_26560356_Chip-Seq_TH2_Human1.29208167
80TFEB_21752829_ChIP-Seq_HELA_Human1.28285941
81* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27296085
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.25699140
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25662857
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.25612558
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25436960
86KDM2B_26808549_Chip-Seq_DND41_Human1.25345825
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25264058
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24492928
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24427716
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.23821393
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21613503
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17967664
93SPI1_23127762_ChIP-Seq_K562_Human1.17809349
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.17779473
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16053624
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.15621510
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15613857
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15559149
99* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15473216
100TTF2_22483619_ChIP-Seq_HELA_Human1.15110552
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13872451
102RACK7_27058665_Chip-Seq_MCF-7_Human1.13445165
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10615618
104LXR_22292898_ChIP-Seq_THP-1_Human1.10060822
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08635659
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08475877
107* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08143783
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07672212
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07598255
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07563470
111* MYB_26560356_Chip-Seq_TH1_Human1.07228384
112* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06730216
113* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06551295
114CTCF_26484167_Chip-Seq_Bcells_Mouse1.05977846
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05803700
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04821459
117* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04791110
118* IRF8_27001747_Chip-Seq_BMDM_Mouse1.04219829
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.04090323
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03978155
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03443939
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02979135
123ELK1_19687146_ChIP-ChIP_HELA_Human1.02800578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.29251431
2MP0000685_abnormal_immune_system3.20500260
3MP0001835_abnormal_antigen_presentation3.13465923
4MP0005671_abnormal_response_to2.99463625
5MP0009785_altered_susceptibility_to2.73855456
6MP0005451_abnormal_body_composition2.40424883
7MP0003763_abnormal_thymus_physiology2.34753761
8MP0001873_stomach_inflammation2.27676369
9MP0002735_abnormal_chemical_nociception2.23025469
10MP0009333_abnormal_splenocyte_physiolog2.21049391
11MP0002148_abnormal_hypersensitivity_rea2.19320297
12MP0005000_abnormal_immune_tolerance2.13818775
13MP0005025_abnormal_response_to2.10846681
14MP0003880_abnormal_central_pattern2.09250845
15MP0005387_immune_system_phenotype2.02983488
16MP0001790_abnormal_immune_system2.02983488
17MP0002736_abnormal_nociception_after1.99402442
18MP0002420_abnormal_adaptive_immunity1.99268218
19MP0002398_abnormal_bone_marrow1.98911653
20MP0002723_abnormal_immune_serum1.97482929
21MP0001819_abnormal_immune_cell1.96810682
22MP0001800_abnormal_humoral_immune1.96592276
23MP0003436_decreased_susceptibility_to1.95283320
24MP0001968_abnormal_touch/_nociception1.93050976
25MP0002396_abnormal_hematopoietic_system1.82467009
26MP0002452_abnormal_antigen_presenting1.82348279
27MP0006082_CNS_inflammation1.81820692
28MP0000749_muscle_degeneration1.76174645
29MP0003806_abnormal_nucleotide_metabolis1.71399460
30MP0002419_abnormal_innate_immunity1.69762946
31MP0000716_abnormal_immune_system1.69317431
32MP0000689_abnormal_spleen_morphology1.66289211
33MP0005058_abnormal_lysosome_morphology1.63746573
34MP0005464_abnormal_platelet_physiology1.62897928
35MP0002405_respiratory_system_inflammati1.61237239
36MP0004510_myositis1.60170014
37MP0003724_increased_susceptibility_to1.59039459
38MP0002722_abnormal_immune_system1.58950213
39MP0003866_abnormal_defecation1.53140265
40MP0003191_abnormal_cellular_cholesterol1.53057642
41MP0003183_abnormal_peptide_metabolism1.52287121
42MP0001970_abnormal_pain_threshold1.52121106
43MP0002429_abnormal_blood_cell1.51909309
44MP0003656_abnormal_erythrocyte_physiolo1.51833709
45MP0001905_abnormal_dopamine_level1.51133966
46MP0005397_hematopoietic_system_phenotyp1.50976268
47MP0001545_abnormal_hematopoietic_system1.50976268
48MP0004947_skin_inflammation1.50198100
49MP0002822_catalepsy1.44267695
50MP0002163_abnormal_gland_morphology1.44070988
51MP0004808_abnormal_hematopoietic_stem1.42757842
52MP0002733_abnormal_thermal_nociception1.40578181
53MP0004147_increased_porphyrin_level1.40338516
54MP0001529_abnormal_vocalization1.37554884
55MP0006036_abnormal_mitochondrial_physio1.35984652
56MP0003646_muscle_fatigue1.33761916
57MP0003300_gastrointestinal_ulcer1.29453247
58MP0003075_altered_response_to1.29046391
59MP0000703_abnormal_thymus_morphology1.28885253
60MP0004859_abnormal_synaptic_plasticity1.27986265
61MP0005310_abnormal_salivary_gland1.27497255
62MP0005075_abnormal_melanosome_morpholog1.27233262
63MP0009840_abnormal_foam_cell1.26404856
64MP0004142_abnormal_muscle_tone1.17558172
65MP0006276_abnormal_autonomic_nervous1.17427332
66MP0002064_seizures1.15082210
67MP0001845_abnormal_inflammatory_respons1.15019672
68MP0001853_heart_inflammation1.14828648
69MP0000751_myopathy1.14297504
70MP0005166_decreased_susceptibility_to1.13776741
71MP0004381_abnormal_hair_follicle1.12010211
72MP0002166_altered_tumor_susceptibility1.09319672
73MP0003172_abnormal_lysosome_physiology1.09266236
74MP0000858_altered_metastatic_potential1.08515178
75MP0004858_abnormal_nervous_system1.04738866
76MP0005423_abnormal_somatic_nervous1.03474570
77MP0002272_abnormal_nervous_system1.02447775
78MP0002132_abnormal_respiratory_system1.01805480
79MP0008260_abnormal_autophagy1.00812287
80MP0002734_abnormal_mechanical_nocicepti1.00008010
81MP0000343_altered_response_to0.98741576
82MP0001348_abnormal_lacrimal_gland0.97527542
83MP0008569_lethality_at_weaning0.96837122
84MP0002006_tumorigenesis0.95528289
85MP0003122_maternal_imprinting0.94643485
86MP0003786_premature_aging0.93235094
87MP0002877_abnormal_melanocyte_morpholog0.92767067
88MP0001533_abnormal_skeleton_physiology0.91069369
89MP0003448_altered_tumor_morphology0.90041759
90MP0010155_abnormal_intestine_physiology0.89844800
91MP0009764_decreased_sensitivity_to0.89609605
92MP0009278_abnormal_bone_marrow0.89357784
93MP0009745_abnormal_behavioral_response0.89338853
94MP0000015_abnormal_ear_pigmentation0.89143283
95MP0004270_analgesia0.87521185
96MP0000490_abnormal_crypts_of0.87301965
97MP0002138_abnormal_hepatobiliary_system0.86519340
98MP0000604_amyloidosis0.86198795
99MP0009763_increased_sensitivity_to0.85593136
100MP0000747_muscle_weakness0.85464152
101MP0006035_abnormal_mitochondrial_morpho0.84499675
102MP0002837_dystrophic_cardiac_calcinosis0.83922509
103MP0002933_joint_inflammation0.83325159
104MP0003635_abnormal_synaptic_transmissio0.83209750
105MP0008469_abnormal_protein_level0.82531942
106MP0003879_abnormal_hair_cell0.79584651
107MP0005584_abnormal_enzyme/coenzyme_acti0.79557370
108MP0006054_spinal_hemorrhage0.78108488
109MP0005174_abnormal_tail_pigmentation0.77879903
110MP0002269_muscular_atrophy0.77584037
111MP0002876_abnormal_thyroid_physiology0.76205336
112MP0009046_muscle_twitch0.76177347
113* MP0002019_abnormal_tumor_incidence0.75901597
114MP0001663_abnormal_digestive_system0.75335696
115MP0000358_abnormal_cell_content/0.72782842
116MP0000681_abnormal_thyroid_gland0.71877485
117MP0003303_peritoneal_inflammation0.70842065
118MP0000465_gastrointestinal_hemorrhage0.69778353
119MP0004811_abnormal_neuron_physiology0.69565144
120MP0002998_abnormal_bone_remodeling0.69303911
121MP0004145_abnormal_muscle_electrophysio0.69270289
122MP0008874_decreased_physiological_sensi0.68172976
123MP0001764_abnormal_homeostasis0.67727734
124MP0002693_abnormal_pancreas_physiology0.66959316
125MP0000313_abnormal_cell_death0.66542499
126MP0003693_abnormal_embryo_hatching0.65614224
127MP0003186_abnormal_redox_activity0.65552736
128MP0004185_abnormal_adipocyte_glucose0.63901204
129MP0008873_increased_physiological_sensi0.63427715
130MP0005390_skeleton_phenotype0.62374171
131MP0005319_abnormal_enzyme/_coenzyme0.61979788
132MP0005165_increased_susceptibility_to0.59941240
133MP0009765_abnormal_xenobiotic_induced0.59158762
134MP0003795_abnormal_bone_structure0.57574519
135MP0005083_abnormal_biliary_tract0.56311967
136MP0001727_abnormal_embryo_implantation0.55763875
137MP0000372_irregular_coat_pigmentation0.55468821
138MP0009643_abnormal_urine_homeostasis0.55119125
139MP0000609_abnormal_liver_physiology0.54973430

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.43964830
2Hepatocellular necrosis (HP:0001404)4.05191077
3Agammaglobulinemia (HP:0004432)3.86682094
4Increased IgM level (HP:0003496)3.52858733
5Recurrent abscess formation (HP:0002722)3.39812490
6Mitochondrial inheritance (HP:0001427)3.38957571
7Hepatic necrosis (HP:0002605)3.31178251
8Myositis (HP:0100614)3.31137055
9Thrombocytosis (HP:0001894)3.28759416
10IgM deficiency (HP:0002850)3.22164031
11Neuroendocrine neoplasm (HP:0100634)3.17170463
12Hypothermia (HP:0002045)3.01579513
13Myokymia (HP:0002411)2.98710538
14Abnormal mitochondria in muscle tissue (HP:0008316)2.96864671
15Chronic otitis media (HP:0000389)2.92830326
16Increased CSF lactate (HP:0002490)2.92627354
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92550007
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92550007
19Increased IgE level (HP:0003212)2.86137416
20Acute necrotizing encephalopathy (HP:0006965)2.85945327
21Abnormal hair whorl (HP:0010721)2.84715042
22Pheochromocytoma (HP:0002666)2.83883536
23Muscle fiber atrophy (HP:0100295)2.81230432
24Lymphopenia (HP:0001888)2.80550589
25Visual hallucinations (HP:0002367)2.73090035
26Type 2 muscle fiber atrophy (HP:0003554)2.71024929
27Encephalitis (HP:0002383)2.66625134
28Abnormality of liposaccharide metabolism (HP:0010968)2.66099416
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.66099416
30Abnormality of glycolipid metabolism (HP:0010969)2.66099416
31Recurrent bronchitis (HP:0002837)2.65620016
32Severe combined immunodeficiency (HP:0004430)2.64816703
33Recurrent bacterial skin infections (HP:0005406)2.64005675
34Focal motor seizures (HP:0011153)2.62456772
35Hypertensive crisis (HP:0100735)2.61951782
36Eczematoid dermatitis (HP:0000976)2.61564261
37Autoimmune hemolytic anemia (HP:0001890)2.60249809
38Granulocytopenia (HP:0001913)2.60246986
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.59745659
40Acute hepatic failure (HP:0006554)2.52456300
41Orchitis (HP:0100796)2.52065015
42IgG deficiency (HP:0004315)2.51819200
43Petechiae (HP:0000967)2.50951149
44Gastrointestinal inflammation (HP:0004386)2.49736335
45Abnormality of macrophages (HP:0004311)2.49263661
46Hepatosplenomegaly (HP:0001433)2.49227841
47Myotonia (HP:0002486)2.46208966
48Increased intramyocellular lipid droplets (HP:0012240)2.45513097
49Emotional lability (HP:0000712)2.44239252
50Chronic mucocutaneous candidiasis (HP:0002728)2.42676547
51Recurrent cutaneous fungal infections (HP:0011370)2.42676547
52Aplastic anemia (HP:0001915)2.40658248
53Inflammation of the large intestine (HP:0002037)2.39040721
54Hypergammaglobulinemia (HP:0010702)2.37602607
55Urticaria (HP:0001025)2.35679258
56Dysautonomia (HP:0002459)2.35328240
57Exertional dyspnea (HP:0002875)2.34139188
58Papilloma (HP:0012740)2.33066031
59Verrucae (HP:0200043)2.33066031
60Increased serum pyruvate (HP:0003542)2.32630104
61Abnormality of glycolysis (HP:0004366)2.32630104
62Type I transferrin isoform profile (HP:0003642)2.32586333
63Combined immunodeficiency (HP:0005387)2.32289254
64Abnormal gallbladder physiology (HP:0012438)2.31370453
65Cholecystitis (HP:0001082)2.31370453
66Abnormality of T cell number (HP:0011839)2.29608920
67Increased serum lactate (HP:0002151)2.29411641
68Recurrent fungal infections (HP:0002841)2.28623540
69Cerebral hypomyelination (HP:0006808)2.27885170
70Colitis (HP:0002583)2.25890511
71B lymphocytopenia (HP:0010976)2.25811301
72Gastrointestinal infarctions (HP:0005244)2.25800223
73Poor suck (HP:0002033)2.24834045
74Gastrointestinal stroma tumor (HP:0100723)2.24670838
75Autoimmune thrombocytopenia (HP:0001973)2.24015460
76Esophageal neoplasm (HP:0100751)2.23942894
77Neoplasm of head and neck (HP:0012288)2.23942894
78Chronic diarrhea (HP:0002028)2.23657390
79Increased muscle lipid content (HP:0009058)2.23509797
80Exercise intolerance (HP:0003546)2.22725914
81Recurrent gram-negative bacterial infections (HP:0005420)2.22663905
82Abnormality of T cells (HP:0002843)2.22243735
83Microvesicular hepatic steatosis (HP:0001414)2.20394833
84Progressive neurologic deterioration (HP:0002344)2.19140429
85Retrobulbar optic neuritis (HP:0100654)2.18363101
86Optic neuritis (HP:0100653)2.18363101
87Pulmonary infiltrates (HP:0002113)2.16946023
88Skin rash (HP:0000988)2.16933900
89Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15650934
90Lactic acidosis (HP:0003128)2.15518615
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13322894
92Abnormality of B cell number (HP:0010975)2.10586241
93Hypokinesia (HP:0002375)2.10354487
94Increased serum ferritin (HP:0003281)2.10016544
95T lymphocytopenia (HP:0005403)2.09980547
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09733970
97Chest pain (HP:0100749)2.09173151
98Abnormality of the nasal mucosa (HP:0000433)2.09037434
99Respiratory failure (HP:0002878)2.08391682
100Progressive macrocephaly (HP:0004481)2.07710804
101Hypercortisolism (HP:0001578)2.07558737
102Obstructive lung disease (HP:0006536)2.06948884
103Chronic obstructive pulmonary disease (HP:0006510)2.06948884
104Sepsis (HP:0100806)2.04733847
105Abnormal number of erythroid precursors (HP:0012131)2.04276515
106Testicular atrophy (HP:0000029)2.04003781
107Aplasia/Hypoplasia of the thymus (HP:0010515)2.03723669
108Increased cerebral lipofuscin (HP:0011813)2.03258455
109Interstitial pulmonary disease (HP:0006530)2.02721759
110Dysostosis multiplex (HP:0000943)2.02277173
111Ragged-red muscle fibers (HP:0003200)2.02253387
112Seborrheic dermatitis (HP:0001051)2.01349758
113Neoplasm of the peripheral nervous system (HP:0100007)2.00061162
114Abnormality of the prostate (HP:0008775)1.98495912
115Abnormality of cells of the erythroid lineage (HP:0012130)1.96937399
116Epistaxis (HP:0000421)1.95826490
117Recurrent viral infections (HP:0004429)1.95549899
118Cellulitis (HP:0100658)1.94614599
119Osteomyelitis (HP:0002754)1.93756498
120Mediastinal lymphadenopathy (HP:0100721)1.92845555
121Nasal polyposis (HP:0100582)1.92518425
122Acute encephalopathy (HP:0006846)1.90753163
123Panhypogammaglobulinemia (HP:0003139)1.90257265
124Abnormality of T cell physiology (HP:0011840)1.90222077
125Recurrent skin infections (HP:0001581)1.90214953
126Eosinophilia (HP:0001880)1.88857362
127Prolonged bleeding time (HP:0003010)1.88382367
128IgA deficiency (HP:0002720)1.87944111
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87644500
130Dicarboxylic aciduria (HP:0003215)1.87644500
131Lymphoma (HP:0002665)1.87179153
132Meningitis (HP:0001287)1.86799903
133Atonic seizures (HP:0010819)1.85678115
134Respiratory difficulties (HP:0002880)1.84267673
135Increased hepatocellular lipid droplets (HP:0006565)1.83059781
136Abnormal protein glycosylation (HP:0012346)1.82695601
137Abnormal glycosylation (HP:0012345)1.82695601
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82695601
139Abnormal protein N-linked glycosylation (HP:0012347)1.82695601
140Vasculitis (HP:0002633)1.82240818
141Abnormal delayed hypersensitivity skin test (HP:0002963)1.82227756
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.82065196
143Abnormal autonomic nervous system physiology (HP:0012332)1.81641296
144Pustule (HP:0200039)1.76775011
145Vacuolated lymphocytes (HP:0001922)1.76348745
146Impaired pain sensation (HP:0007328)1.74899514
147Abnormality of pain sensation (HP:0010832)1.74899514
148Joint stiffness (HP:0001387)1.73879347
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.73382408
150Stomatitis (HP:0010280)1.72977827
151* Vertebral compression fractures (HP:0002953)1.71615534
152Chronic sinusitis (HP:0011109)1.70220626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.57369445
2MAP4K13.35426749
3VRK22.81870258
4SIK32.72029534
5PIM22.71010146
6TXK2.68315953
7ARAF2.47130428
8DAPK12.33190796
9BCKDK2.32987042
10MYLK2.27411465
11NME22.25197177
12BUB12.23219403
13ZAP702.21234656
14TBK12.05566611
15CDK191.97865156
16SMG11.93040757
17KIT1.91127902
18MATK1.62901551
19KDR1.60220639
20MAP3K111.59043547
21BLK1.55815912
22ADRBK21.55043427
23SYK1.53013512
24JAK31.49770905
25ILK1.47386958
26RIPK41.43709648
27SCYL21.42663777
28TESK21.36293850
29IRAK31.34641358
30IKBKE1.33137978
31GRK51.32030156
32LIMK11.27413659
33BTK1.25279340
34TSSK61.21872794
35TAOK21.21218032
36CDK81.15992988
37CAMKK21.12393710
38MAPKAPK31.10645303
39MAP3K131.08857601
40TYK21.08839057
41FES1.08760759
42DAPK31.08363363
43STK161.08356565
44LRRK21.04084455
45TLK11.03786388
46LCK1.03176470
47CCNB10.99593895
48TESK10.95008561
49GRK60.94838479
50PRPF4B0.94541172
51TEC0.94423604
52MUSK0.93231359
53TRIB30.93159847
54CASK0.92669695
55RAF10.92567928
56IRAK40.91501792
57VRK10.91329443
58MAPK110.86972590
59TNK20.84337401
60IKBKB0.83763366
61CSF1R0.83006357
62EIF2AK10.80181330
63MAP2K70.79290403
64LYN0.78470340
65MAP3K30.78426966
66PRKCH0.77740034
67MAP2K30.76441655
68NEK10.76437580
69PIM10.75558386
70MINK10.74750940
71SIK20.74333178
72NEK90.73886798
73UHMK10.71986928
74KSR20.70839272
75TAOK10.70525668
76RPS6KA60.69471413
77MAPKAPK50.69238737
78GRK70.69072224
79ITK0.66316519
80ERN10.65954114
81RPS6KC10.61109879
82RPS6KL10.61109879
83BMPR20.60494952
84FLT30.60162926
85MST40.59018081
86PRKG20.58726937
87SIK10.58558413
88BRAF0.58479559
89NME10.58129410
90PDK10.57557914
91MAPKAPK20.57483605
92STK100.56454097
93RPS6KA50.55703040
94MARK30.54922672
95AURKA0.54824309
96PRKCQ0.54542706
97PKN20.54068709
98MAP2K60.53792626
99EPHB10.53691377
100HIPK20.53444615
101PAK40.51930690
102CDK40.51675247
103TAOK30.51643740
104CSK0.51412620
105MAPK120.51089221
106PRKCD0.50670456
107PDPK10.50019731
108MAP3K140.49943642
109EIF2AK30.48868580
110PAK10.47832845
111CDK180.46969572
112ABL20.46805671
113NLK0.46795431
114MAP3K10.46573905
115PRKD20.46523575
116ADRBK10.45406739
117MAP3K80.44983269
118JAK10.44758419
119STK240.44348024
120CDK140.44286586
121MAP2K20.44011147
122IRAK20.43843444
123JAK20.42669327
124PIK3CG0.42083837
125TGFBR10.41920806
126CAMKK10.41129669
127MOS0.41025592
128RPS6KA40.40911145
129CDK11A0.40013561
130NTRK10.38926045
131NTRK30.38700828
132HCK0.37794179
133CDK150.35994897
134PASK0.33698663
135PRKCI0.31623720
136FGFR40.31167091
137FYN0.28187119
138FGR0.27669619

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.67590838
2Oxidative phosphorylation_Homo sapiens_hsa001902.63312513
3Parkinsons disease_Homo sapiens_hsa050122.58192205
4Ribosome_Homo sapiens_hsa030102.57917409
5Primary immunodeficiency_Homo sapiens_hsa053402.46760126
6DNA replication_Homo sapiens_hsa030302.21991872
7Synaptic vesicle cycle_Homo sapiens_hsa047212.19095722
8Collecting duct acid secretion_Homo sapiens_hsa049662.10905035
9Base excision repair_Homo sapiens_hsa034102.01573286
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81420533
11Mismatch repair_Homo sapiens_hsa034301.78344568
12Alzheimers disease_Homo sapiens_hsa050101.63539457
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.61853578
14Allograft rejection_Homo sapiens_hsa053301.58554346
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56973756
16Rheumatoid arthritis_Homo sapiens_hsa053231.55382059
17Staphylococcus aureus infection_Homo sapiens_hsa051501.53323112
18RNA polymerase_Homo sapiens_hsa030201.52452657
19Shigellosis_Homo sapiens_hsa051311.49753474
20Systemic lupus erythematosus_Homo sapiens_hsa053221.47516351
21Vibrio cholerae infection_Homo sapiens_hsa051101.46898338
22Huntingtons disease_Homo sapiens_hsa050161.46591074
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46328653
24Protein export_Homo sapiens_hsa030601.45465087
25Type I diabetes mellitus_Homo sapiens_hsa049401.37854401
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.37047278
27Graft-versus-host disease_Homo sapiens_hsa053321.36867650
28Leishmaniasis_Homo sapiens_hsa051401.36125119
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30750480
30Measles_Homo sapiens_hsa051621.29729714
31Phagosome_Homo sapiens_hsa041451.22542275
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18181271
33Antigen processing and presentation_Homo sapiens_hsa046121.15249288
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14046669
35Nucleotide excision repair_Homo sapiens_hsa034201.08479818
36Pyrimidine metabolism_Homo sapiens_hsa002401.06909807
37Legionellosis_Homo sapiens_hsa051341.05463015
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.02785507
39Hematopoietic cell lineage_Homo sapiens_hsa046401.01803496
40Phototransduction_Homo sapiens_hsa047440.99679567
41Salmonella infection_Homo sapiens_hsa051320.99479987
42Olfactory transduction_Homo sapiens_hsa047400.97661895
43B cell receptor signaling pathway_Homo sapiens_hsa046620.96237230
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94168416
45Epstein-Barr virus infection_Homo sapiens_hsa051690.91131756
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90644343
47Tuberculosis_Homo sapiens_hsa051520.90392378
48T cell receptor signaling pathway_Homo sapiens_hsa046600.88907288
49Lysosome_Homo sapiens_hsa041420.88536120
50Spliceosome_Homo sapiens_hsa030400.88420081
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87970792
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86954120
53Homologous recombination_Homo sapiens_hsa034400.86415143
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84676217
55Cardiac muscle contraction_Homo sapiens_hsa042600.81867470
56HTLV-I infection_Homo sapiens_hsa051660.81126228
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79922409
58Osteoclast differentiation_Homo sapiens_hsa043800.79432985
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76297290
60Autoimmune thyroid disease_Homo sapiens_hsa053200.75357612
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75321924
62Regulation of autophagy_Homo sapiens_hsa041400.74968095
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.74400807
64Pertussis_Homo sapiens_hsa051330.73267744
65Purine metabolism_Homo sapiens_hsa002300.72489500
66Non-small cell lung cancer_Homo sapiens_hsa052230.72302693
67Apoptosis_Homo sapiens_hsa042100.70630020
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69844913
69Acute myeloid leukemia_Homo sapiens_hsa052210.69839778
70Chemokine signaling pathway_Homo sapiens_hsa040620.69744277
71Fructose and mannose metabolism_Homo sapiens_hsa000510.69199894
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.68371693
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68018991
74Other glycan degradation_Homo sapiens_hsa005110.65251491
75Hepatitis B_Homo sapiens_hsa051610.63196583
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63124714
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62530565
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62155824
79Platelet activation_Homo sapiens_hsa046110.60707563
80TNF signaling pathway_Homo sapiens_hsa046680.60434494
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60266053
82Sulfur relay system_Homo sapiens_hsa041220.59587104
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.59239726
84N-Glycan biosynthesis_Homo sapiens_hsa005100.59112111
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59096426
86Malaria_Homo sapiens_hsa051440.58581633
87Fatty acid elongation_Homo sapiens_hsa000620.58282172
88Biosynthesis of amino acids_Homo sapiens_hsa012300.57185455
89Influenza A_Homo sapiens_hsa051640.57014198
90Thyroid cancer_Homo sapiens_hsa052160.55968983
91Galactose metabolism_Homo sapiens_hsa000520.55913350
92Herpes simplex infection_Homo sapiens_hsa051680.55161816
93Carbon metabolism_Homo sapiens_hsa012000.54279496
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54054709
95Dopaminergic synapse_Homo sapiens_hsa047280.52679316
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51595741
97Pancreatic cancer_Homo sapiens_hsa052120.51285806
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49812044
99RNA degradation_Homo sapiens_hsa030180.49526026
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49007054
101Endocytosis_Homo sapiens_hsa041440.48994815
102Asthma_Homo sapiens_hsa053100.47683690
103Morphine addiction_Homo sapiens_hsa050320.44997465
104Alcoholism_Homo sapiens_hsa050340.44810643
105Viral myocarditis_Homo sapiens_hsa054160.44786016
106Hepatitis C_Homo sapiens_hsa051600.44588342
107VEGF signaling pathway_Homo sapiens_hsa043700.44198854
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42339759
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38832185
110RNA transport_Homo sapiens_hsa030130.38790782
111Chronic myeloid leukemia_Homo sapiens_hsa052200.37472071
112African trypanosomiasis_Homo sapiens_hsa051430.37096146
113Pentose phosphate pathway_Homo sapiens_hsa000300.35950669
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.35840680
115Toxoplasmosis_Homo sapiens_hsa051450.35423002
116Circadian entrainment_Homo sapiens_hsa047130.34127109
117HIF-1 signaling pathway_Homo sapiens_hsa040660.33413392
118Cell cycle_Homo sapiens_hsa041100.32936133
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.32639784
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32543910
121Viral carcinogenesis_Homo sapiens_hsa052030.32434724
122Glutathione metabolism_Homo sapiens_hsa004800.31806933
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28021825

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »