

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 6.70157139 |
| 2 | neuron cell-cell adhesion (GO:0007158) | 6.25582684 |
| 3 | vocalization behavior (GO:0071625) | 5.78104340 |
| 4 | cellular potassium ion homeostasis (GO:0030007) | 5.47264806 |
| 5 | sodium ion export (GO:0071436) | 5.28819316 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.20897542 |
| 7 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.17827657 |
| 8 | neuronal ion channel clustering (GO:0045161) | 5.06936544 |
| 9 | synaptic vesicle exocytosis (GO:0016079) | 5.03634666 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.98598049 |
| 11 | protein localization to synapse (GO:0035418) | 4.77387099 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.68407520 |
| 13 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.57030322 |
| 14 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.55093779 |
| 15 | dopamine transport (GO:0015872) | 4.52280145 |
| 16 | locomotory exploration behavior (GO:0035641) | 4.51872409 |
| 17 | dopamine biosynthetic process (GO:0042416) | 4.51280338 |
| 18 | glutamate receptor signaling pathway (GO:0007215) | 4.44856703 |
| 19 | neuron recognition (GO:0008038) | 4.40344560 |
| 20 | glutamate secretion (GO:0014047) | 4.35975569 |
| 21 | exploration behavior (GO:0035640) | 4.27939436 |
| 22 | mating behavior (GO:0007617) | 4.22421559 |
| 23 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.20234474 |
| 24 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.17336492 |
| 25 | neuron-neuron synaptic transmission (GO:0007270) | 4.16685446 |
| 26 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.13661948 |
| 27 | response to histamine (GO:0034776) | 4.13143909 |
| 28 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.07864186 |
| 29 | presynaptic membrane assembly (GO:0097105) | 4.07086361 |
| 30 | behavioral response to cocaine (GO:0048148) | 4.06544359 |
| 31 | neurotransmitter secretion (GO:0007269) | 4.04328807 |
| 32 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.00449451 |
| 33 | neuronal action potential propagation (GO:0019227) | 3.99975998 |
| 34 | synaptic vesicle maturation (GO:0016188) | 3.99109577 |
| 35 | synaptic transmission, dopaminergic (GO:0001963) | 3.92281384 |
| 36 | synaptic transmission, glutamatergic (GO:0035249) | 3.87074799 |
| 37 | dendritic spine morphogenesis (GO:0060997) | 3.86115677 |
| 38 | cerebellar granule cell differentiation (GO:0021707) | 3.84665738 |
| 39 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.78895465 |
| 40 | presynaptic membrane organization (GO:0097090) | 3.77329304 |
| 41 | postsynaptic membrane organization (GO:0001941) | 3.75808796 |
| 42 | layer formation in cerebral cortex (GO:0021819) | 3.73872413 |
| 43 | L-amino acid import (GO:0043092) | 3.73510209 |
| 44 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.73251346 |
| 45 | transmission of nerve impulse (GO:0019226) | 3.72771387 |
| 46 | potassium ion homeostasis (GO:0055075) | 3.71085687 |
| 47 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.70303344 |
| 48 | regulation of synaptic vesicle transport (GO:1902803) | 3.69507227 |
| 49 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.68447733 |
| 50 | neurotransmitter transport (GO:0006836) | 3.67320476 |
| 51 | cell communication by electrical coupling (GO:0010644) | 3.65991520 |
| 52 | cellular sodium ion homeostasis (GO:0006883) | 3.65743542 |
| 53 | catecholamine transport (GO:0051937) | 3.64291449 |
| 54 | prepulse inhibition (GO:0060134) | 3.63168053 |
| 55 | regulation of postsynaptic membrane potential (GO:0060078) | 3.62092103 |
| 56 | regulation of neurotransmitter levels (GO:0001505) | 3.61850659 |
| 57 | axon ensheathment in central nervous system (GO:0032291) | 3.61629622 |
| 58 | central nervous system myelination (GO:0022010) | 3.61629622 |
| 59 | regulation of synapse structural plasticity (GO:0051823) | 3.60292346 |
| 60 | axonal fasciculation (GO:0007413) | 3.59099284 |
| 61 | potassium ion import (GO:0010107) | 3.58992029 |
| 62 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.57938647 |
| 63 | regulation of catecholamine metabolic process (GO:0042069) | 3.57217688 |
| 64 | regulation of dopamine metabolic process (GO:0042053) | 3.57217688 |
| 65 | regulation of glutamate secretion (GO:0014048) | 3.56260609 |
| 66 | membrane depolarization during action potential (GO:0086010) | 3.54175837 |
| 67 | amino acid import (GO:0043090) | 3.54032047 |
| 68 | positive regulation of synapse assembly (GO:0051965) | 3.52382484 |
| 69 | regulation of vesicle fusion (GO:0031338) | 3.49083043 |
| 70 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.48959382 |
| 71 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.47694650 |
| 72 | long-term memory (GO:0007616) | 3.47270502 |
| 73 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.45178029 |
| 74 | positive regulation of dendritic spine development (GO:0060999) | 3.42176725 |
| 75 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.42099880 |
| 76 | synapse assembly (GO:0007416) | 3.39776751 |
| 77 | regulation of neurotransmitter secretion (GO:0046928) | 3.38507338 |
| 78 | long-term synaptic potentiation (GO:0060291) | 3.35372346 |
| 79 | intraspecies interaction between organisms (GO:0051703) | 3.33620989 |
| 80 | social behavior (GO:0035176) | 3.33620989 |
| 81 | regulation of protein kinase A signaling (GO:0010738) | 3.32280483 |
| 82 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.32273882 |
| 83 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.32081037 |
| 84 | startle response (GO:0001964) | 3.31688398 |
| 85 | negative regulation of neurotransmitter transport (GO:0051589) | 3.31225384 |
| 86 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.31180170 |
| 87 | auditory behavior (GO:0031223) | 3.27676688 |
| 88 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.26379991 |
| 89 | synaptic vesicle endocytosis (GO:0048488) | 3.25795385 |
| 90 | neuromuscular process controlling balance (GO:0050885) | 3.25771736 |
| 91 | response to amphetamine (GO:0001975) | 3.24244843 |
| 92 | neuron remodeling (GO:0016322) | 3.23494803 |
| 93 | gamma-aminobutyric acid transport (GO:0015812) | 3.22639665 |
| 94 | serotonin metabolic process (GO:0042428) | 3.22485255 |
| 95 | positive regulation of membrane potential (GO:0045838) | 3.21066241 |
| 96 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.20912032 |
| 97 | regulation of synapse maturation (GO:0090128) | 3.18168667 |
| 98 | striatum development (GO:0021756) | 3.17885496 |
| 99 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.17800243 |
| 100 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.16636658 |
| 101 | positive regulation of synapse maturation (GO:0090129) | 3.16073333 |
| 102 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.15296248 |
| 103 | regulation of neurotransmitter transport (GO:0051588) | 3.12513924 |
| 104 | cell migration in hindbrain (GO:0021535) | 3.10724056 |
| 105 | neurotransmitter catabolic process (GO:0042135) | 3.10036030 |
| 106 | membrane depolarization (GO:0051899) | 3.09885452 |
| 107 | cell communication involved in cardiac conduction (GO:0086065) | 3.09741384 |
| 108 | regulation of synaptic plasticity (GO:0048167) | 3.09251739 |
| 109 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.09007633 |
| 110 | response to cocaine (GO:0042220) | 3.07515585 |
| 111 | detection of calcium ion (GO:0005513) | 3.07391300 |
| 112 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.06875017 |
| 113 | innervation (GO:0060384) | 3.04601213 |
| 114 | membrane hyperpolarization (GO:0060081) | 3.04250201 |
| 115 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.03721107 |
| 116 | ATP synthesis coupled proton transport (GO:0015986) | 3.03721107 |
| 117 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.03647892 |
| 118 | establishment of synaptic vesicle localization (GO:0097480) | 3.03242033 |
| 119 | synaptic vesicle transport (GO:0048489) | 3.03242033 |
| 120 | learning (GO:0007612) | 3.03173107 |
| 121 | righting reflex (GO:0060013) | 3.02946189 |
| 122 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.01377094 |
| 123 | behavioral defense response (GO:0002209) | 3.01329223 |
| 124 | behavioral fear response (GO:0001662) | 3.01329223 |
| 125 | regulation of dendritic spine development (GO:0060998) | 3.00940128 |
| 126 | positive regulation of neurotransmitter transport (GO:0051590) | 2.99678064 |
| 127 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.98984026 |
| 128 | neurotransmitter uptake (GO:0001504) | 2.98579135 |
| 129 | cell differentiation in hindbrain (GO:0021533) | 2.92862126 |
| 130 | establishment of mitochondrion localization (GO:0051654) | 2.91642105 |
| 131 | neuromuscular process (GO:0050905) | 2.90235431 |
| 132 | neuromuscular synaptic transmission (GO:0007274) | 2.89402487 |
| 133 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.89359738 |
| 134 | synaptic transmission (GO:0007268) | 2.89218161 |
| 135 | adult walking behavior (GO:0007628) | 2.87967118 |
| 136 | dendrite morphogenesis (GO:0048813) | 2.86951173 |
| 137 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.78992483 |
| 138 | response to auditory stimulus (GO:0010996) | 2.77789132 |
| 139 | regulation of synaptic transmission (GO:0050804) | 2.77658198 |
| 140 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.76485341 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.30669098 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.95485034 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.19677099 |
| 4 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.17918078 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.11389527 |
| 6 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.83217440 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.74095240 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.67553888 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.67553888 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.63896292 |
| 11 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.60587553 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.58694276 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.57259918 |
| 14 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.52465894 |
| 15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.45625809 |
| 16 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.45017155 |
| 17 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43562453 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.41004279 |
| 19 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.35007293 |
| 20 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.28867522 |
| 21 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.20674598 |
| 22 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.19667191 |
| 23 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.19400784 |
| 24 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.10100711 |
| 25 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.07185470 |
| 26 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.07138869 |
| 27 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.00166922 |
| 28 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.97573177 |
| 29 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.96792833 |
| 30 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.87912256 |
| 31 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.83169206 |
| 32 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.81557090 |
| 33 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.78164324 |
| 34 | P300_19829295_ChIP-Seq_ESCs_Human | 1.77702473 |
| 35 | * CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.73445848 |
| 36 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.71731929 |
| 37 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.70721889 |
| 38 | VDR_22108803_ChIP-Seq_LS180_Human | 1.70529931 |
| 39 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.68648157 |
| 40 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.68505895 |
| 41 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.66016684 |
| 42 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.59941925 |
| 43 | FUS_26573619_Chip-Seq_HEK293_Human | 1.57284649 |
| 44 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.54971614 |
| 45 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.53684003 |
| 46 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.53084287 |
| 47 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.50909273 |
| 48 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.49118735 |
| 49 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.48753987 |
| 50 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.48410668 |
| 51 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.47031234 |
| 52 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.43162358 |
| 53 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.41667533 |
| 54 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.41132081 |
| 55 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.39711341 |
| 56 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.39593266 |
| 57 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.34623549 |
| 58 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.32597718 |
| 59 | AR_25329375_ChIP-Seq_VCAP_Human | 1.31534732 |
| 60 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.29072834 |
| 61 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.26455029 |
| 62 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.25716501 |
| 63 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.25104220 |
| 64 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.22519353 |
| 65 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21729826 |
| 66 | STAT3_23295773_ChIP-Seq_U87_Human | 1.17309115 |
| 67 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.15825396 |
| 68 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.15669507 |
| 69 | JUN_21703547_ChIP-Seq_K562_Human | 1.14329318 |
| 70 | TP53_16413492_ChIP-PET_HCT116_Human | 1.14076533 |
| 71 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.13751429 |
| 72 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.12377118 |
| 73 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08815524 |
| 74 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.08766300 |
| 75 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.08148744 |
| 76 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.08018602 |
| 77 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.07958451 |
| 78 | TCF4_23295773_ChIP-Seq_U87_Human | 1.07299376 |
| 79 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.06328779 |
| 80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.06198943 |
| 81 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.05644498 |
| 82 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05631317 |
| 83 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.05588602 |
| 84 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.05384386 |
| 85 | * MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05140338 |
| 86 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.05039234 |
| 87 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.04453678 |
| 88 | * TP53_18474530_ChIP-ChIP_U2OS_Human | 1.03122480 |
| 89 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.02741848 |
| 90 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.02564583 |
| 91 | KDM2B_26808549_Chip-Seq_K562_Human | 1.02256716 |
| 92 | AR_19668381_ChIP-Seq_PC3_Human | 1.02021535 |
| 93 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.01779074 |
| 94 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.01208849 |
| 95 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01208849 |
| 96 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.00576199 |
| 97 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00548156 |
| 98 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.99734217 |
| 99 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.99447962 |
| 100 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.97875106 |
| 101 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.96997424 |
| 102 | EWS_26573619_Chip-Seq_HEK293_Human | 0.96971352 |
| 103 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96218650 |
| 104 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.96174088 |
| 105 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.96094437 |
| 106 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.95342562 |
| 107 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.94123409 |
| 108 | KDM2B_26808549_Chip-Seq_REH_Human | 0.93903132 |
| 109 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.93803598 |
| 110 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.93289454 |
| 111 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.92273523 |
| 112 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.92170313 |
| 113 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.91170407 |
| 114 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.91107823 |
| 115 | * SOX9_26525672_Chip-Seq_HEART_Mouse | 0.90517591 |
| 116 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.90106645 |
| 117 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.90086911 |
| 118 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.89826839 |
| 119 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.89810934 |
| 120 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.89792880 |
| 121 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.88613153 |
| 122 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.88479348 |
| 123 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.86050937 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 6.43974575 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.93721851 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.88175713 |
| 4 | MP0009745_abnormal_behavioral_response | 3.40006839 |
| 5 | MP0006276_abnormal_autonomic_nervous | 3.22648982 |
| 6 | MP0001529_abnormal_vocalization | 3.19130268 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.12134741 |
| 8 | MP0002064_seizures | 3.07139582 |
| 9 | MP0009046_muscle_twitch | 3.03947864 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.92883982 |
| 11 | MP0005423_abnormal_somatic_nervous | 2.90269225 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.85426173 |
| 13 | MP0001501_abnormal_sleep_pattern | 2.84596855 |
| 14 | MP0004270_analgesia | 2.79097831 |
| 15 | MP0001905_abnormal_dopamine_level | 2.61385039 |
| 16 | MP0001486_abnormal_startle_reflex | 2.58317812 |
| 17 | MP0002272_abnormal_nervous_system | 2.56541586 |
| 18 | MP0003878_abnormal_ear_physiology | 2.49950620 |
| 19 | MP0005377_hearing/vestibular/ear_phenot | 2.49950620 |
| 20 | MP0002736_abnormal_nociception_after | 2.35520710 |
| 21 | MP0001440_abnormal_grooming_behavior | 2.33960478 |
| 22 | MP0002734_abnormal_mechanical_nocicepti | 2.30487073 |
| 23 | MP0002822_catalepsy | 2.22478958 |
| 24 | MP0000569_abnormal_digit_pigmentation | 2.12680098 |
| 25 | MP0002733_abnormal_thermal_nociception | 2.08242443 |
| 26 | MP0002067_abnormal_sensory_capabilities | 2.03749932 |
| 27 | MP0005386_behavior/neurological_phenoty | 2.03442252 |
| 28 | MP0004924_abnormal_behavior | 2.03442252 |
| 29 | MP0002184_abnormal_innervation | 1.99444115 |
| 30 | MP0003122_maternal_imprinting | 1.94098884 |
| 31 | MP0001970_abnormal_pain_threshold | 1.90822378 |
| 32 | MP0002735_abnormal_chemical_nociception | 1.89142570 |
| 33 | MP0000778_abnormal_nervous_system | 1.84965249 |
| 34 | MP0001188_hyperpigmentation | 1.81656935 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.79494656 |
| 36 | MP0001984_abnormal_olfaction | 1.68269518 |
| 37 | MP0003329_amyloid_beta_deposits | 1.59350772 |
| 38 | MP0002837_dystrophic_cardiac_calcinosis | 1.51762217 |
| 39 | MP0004142_abnormal_muscle_tone | 1.51645180 |
| 40 | MP0002909_abnormal_adrenal_gland | 1.50864687 |
| 41 | MP0002066_abnormal_motor_capabilities/c | 1.40874400 |
| 42 | MP0001502_abnormal_circadian_rhythm | 1.40121402 |
| 43 | MP0000955_abnormal_spinal_cord | 1.34113357 |
| 44 | MP0004811_abnormal_neuron_physiology | 1.32231621 |
| 45 | MP0008569_lethality_at_weaning | 1.31457168 |
| 46 | MP0004742_abnormal_vestibular_system | 1.31321493 |
| 47 | MP0000579_abnormal_nail_morphology | 1.31096201 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.30228263 |
| 49 | MP0005409_darkened_coat_color | 1.29779469 |
| 50 | MP0002882_abnormal_neuron_morphology | 1.29577194 |
| 51 | MP0000566_synostosis | 1.24809805 |
| 52 | MP0005257_abnormal_intraocular_pressure | 1.23877440 |
| 53 | MP0005645_abnormal_hypothalamus_physiol | 1.22897821 |
| 54 | MP0003879_abnormal_hair_cell | 1.17930017 |
| 55 | MP0008872_abnormal_physiological_respon | 1.16938667 |
| 56 | MP0005535_abnormal_body_temperature | 1.14634508 |
| 57 | MP0004145_abnormal_muscle_electrophysio | 1.11262196 |
| 58 | MP0009780_abnormal_chondrocyte_physiolo | 1.10299384 |
| 59 | MP0001299_abnormal_eye_distance/ | 1.03861975 |
| 60 | MP0000751_myopathy | 1.03366158 |
| 61 | MP0002152_abnormal_brain_morphology | 1.03046865 |
| 62 | MP0005551_abnormal_eye_electrophysiolog | 0.99879806 |
| 63 | MP0005248_abnormal_Harderian_gland | 0.99648703 |
| 64 | MP0009379_abnormal_foot_pigmentation | 0.97878482 |
| 65 | MP0003283_abnormal_digestive_organ | 0.95704092 |
| 66 | MP0003633_abnormal_nervous_system | 0.94803554 |
| 67 | MP0005499_abnormal_olfactory_system | 0.94643441 |
| 68 | MP0005394_taste/olfaction_phenotype | 0.94643441 |
| 69 | MP0003787_abnormal_imprinting | 0.92842590 |
| 70 | MP0003631_nervous_system_phenotype | 0.92637090 |
| 71 | MP0001664_abnormal_digestion | 0.92475910 |
| 72 | MP0000631_abnormal_neuroendocrine_gland | 0.89126982 |
| 73 | MP0002069_abnormal_eating/drinking_beha | 0.86714733 |
| 74 | MP0001963_abnormal_hearing_physiology | 0.86087768 |
| 75 | MP0002229_neurodegeneration | 0.85860690 |
| 76 | MP0004085_abnormal_heartbeat | 0.85781871 |
| 77 | MP0004858_abnormal_nervous_system | 0.85367273 |
| 78 | MP0004885_abnormal_endolymph | 0.83905972 |
| 79 | MP0002752_abnormal_somatic_nervous | 0.83078814 |
| 80 | MP0003938_abnormal_ear_development | 0.83011061 |
| 81 | MP0004133_heterotaxia | 0.82304334 |
| 82 | MP0002876_abnormal_thyroid_physiology | 0.82126971 |
| 83 | MP0008874_decreased_physiological_sensi | 0.82070291 |
| 84 | MP0010386_abnormal_urinary_bladder | 0.81663370 |
| 85 | MP0006072_abnormal_retinal_apoptosis | 0.79160597 |
| 86 | MP0002090_abnormal_vision | 0.76208132 |
| 87 | MP0003119_abnormal_digestive_system | 0.74723923 |
| 88 | MP0003632_abnormal_nervous_system | 0.74437574 |
| 89 | MP0000013_abnormal_adipose_tissue | 0.74071059 |
| 90 | MP0005379_endocrine/exocrine_gland_phen | 0.73347718 |
| 91 | MP0002102_abnormal_ear_morphology | 0.71935213 |
| 92 | MP0001346_abnormal_lacrimal_gland | 0.71021413 |
| 93 | MP0003634_abnormal_glial_cell | 0.68210732 |
| 94 | MP0003890_abnormal_embryonic-extraembry | 0.68151734 |
| 95 | MP0004043_abnormal_pH_regulation | 0.67785319 |
| 96 | MP0001177_atelectasis | 0.66364471 |
| 97 | MP0001943_abnormal_respiration | 0.65096368 |
| 98 | MP0003137_abnormal_impulse_conducting | 0.64253928 |
| 99 | MP0000026_abnormal_inner_ear | 0.63975565 |
| 100 | MP0000920_abnormal_myelination | 0.63747273 |
| 101 | MP0004484_altered_response_of | 0.63142554 |
| 102 | MP0000604_amyloidosis | 0.62985235 |
| 103 | MP0010769_abnormal_survival | 0.62297834 |
| 104 | MP0002332_abnormal_exercise_endurance | 0.61539853 |
| 105 | MP0003123_paternal_imprinting | 0.61104992 |
| 106 | MP0003121_genomic_imprinting | 0.60347528 |
| 107 | MP0004215_abnormal_myocardial_fiber | 0.60277219 |
| 108 | MP0001348_abnormal_lacrimal_gland | 0.60102935 |
| 109 | MP0002082_postnatal_lethality | 0.58912116 |
| 110 | MP0010768_mortality/aging | 0.58435996 |
| 111 | MP0005187_abnormal_penis_morphology | 0.57614268 |
| 112 | MP0000639_abnormal_adrenal_gland | 0.57180762 |
| 113 | MP0002638_abnormal_pupillary_reflex | 0.53587232 |
| 114 | MP0005623_abnormal_meninges_morphology | 0.53495742 |
| 115 | MP0005171_absent_coat_pigmentation | 0.52439675 |
| 116 | MP0003861_abnormal_nervous_system | 0.51885543 |
| 117 | MP0001485_abnormal_pinna_reflex | 0.51293991 |
| 118 | MP0002751_abnormal_autonomic_nervous | 0.51280962 |
| 119 | MP0003690_abnormal_glial_cell | 0.50516482 |
| 120 | MP0000538_abnormal_urinary_bladder | 0.50417840 |
| 121 | MP0010770_preweaning_lethality | 0.49142122 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.16966699 |
| 2 | Limb dystonia (HP:0002451) | 5.64343768 |
| 3 | Focal seizures (HP:0007359) | 5.50470179 |
| 4 | Visual hallucinations (HP:0002367) | 5.26824650 |
| 5 | Myokymia (HP:0002411) | 5.19389141 |
| 6 | Atonic seizures (HP:0010819) | 4.60086999 |
| 7 | Epileptic encephalopathy (HP:0200134) | 4.37811167 |
| 8 | Progressive cerebellar ataxia (HP:0002073) | 4.21876134 |
| 9 | Hyperventilation (HP:0002883) | 4.20674897 |
| 10 | Absence seizures (HP:0002121) | 4.15755465 |
| 11 | Febrile seizures (HP:0002373) | 4.02200121 |
| 12 | Broad-based gait (HP:0002136) | 3.89101927 |
| 13 | Dialeptic seizures (HP:0011146) | 3.87027688 |
| 14 | Cerebral inclusion bodies (HP:0100314) | 3.83878141 |
| 15 | Aplasia involving bones of the upper limbs (HP:0009823) | 3.82906081 |
| 16 | Aplasia of the phalanges of the hand (HP:0009802) | 3.82906081 |
| 17 | Aplasia involving bones of the extremities (HP:0009825) | 3.82906081 |
| 18 | Generalized tonic-clonic seizures (HP:0002069) | 3.73547505 |
| 19 | Postural instability (HP:0002172) | 3.52323659 |
| 20 | Neurofibrillary tangles (HP:0002185) | 3.39813451 |
| 21 | Amblyopia (HP:0000646) | 3.22760940 |
| 22 | Pheochromocytoma (HP:0002666) | 3.16119791 |
| 23 | Anxiety (HP:0000739) | 3.03832202 |
| 24 | Supranuclear gaze palsy (HP:0000605) | 3.00645215 |
| 25 | Papilledema (HP:0001085) | 2.90207539 |
| 26 | Acute necrotizing encephalopathy (HP:0006965) | 2.88982142 |
| 27 | Truncal ataxia (HP:0002078) | 2.88600469 |
| 28 | Excessive salivation (HP:0003781) | 2.86274843 |
| 29 | Drooling (HP:0002307) | 2.86274843 |
| 30 | Alacrima (HP:0000522) | 2.85749770 |
| 31 | Progressive inability to walk (HP:0002505) | 2.82614829 |
| 32 | Poor eye contact (HP:0000817) | 2.81946859 |
| 33 | Neuroendocrine neoplasm (HP:0100634) | 2.78801664 |
| 34 | Gaze-evoked nystagmus (HP:0000640) | 2.78385148 |
| 35 | Dysmetria (HP:0001310) | 2.67933373 |
| 36 | Progressive macrocephaly (HP:0004481) | 2.67748933 |
| 37 | Obstructive sleep apnea (HP:0002870) | 2.64457093 |
| 38 | Hemiparesis (HP:0001269) | 2.53846041 |
| 39 | Abnormal social behavior (HP:0012433) | 2.52571772 |
| 40 | Impaired social interactions (HP:0000735) | 2.52571772 |
| 41 | Polyphagia (HP:0002591) | 2.52524856 |
| 42 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.51389338 |
| 43 | Epileptiform EEG discharges (HP:0011182) | 2.51345063 |
| 44 | Inability to walk (HP:0002540) | 2.49112890 |
| 45 | Abnormal eating behavior (HP:0100738) | 2.49082816 |
| 46 | Action tremor (HP:0002345) | 2.48720746 |
| 47 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.48197822 |
| 48 | Delusions (HP:0000746) | 2.47047144 |
| 49 | Focal dystonia (HP:0004373) | 2.45864724 |
| 50 | Dysdiadochokinesis (HP:0002075) | 2.45356913 |
| 51 | Abnormality of binocular vision (HP:0011514) | 2.41633290 |
| 52 | Diplopia (HP:0000651) | 2.41633290 |
| 53 | Absent speech (HP:0001344) | 2.41410890 |
| 54 | Depression (HP:0000716) | 2.40607700 |
| 55 | Sleep apnea (HP:0010535) | 2.40082254 |
| 56 | Failure to thrive in infancy (HP:0001531) | 2.38654137 |
| 57 | Amyotrophic lateral sclerosis (HP:0007354) | 2.38477353 |
| 58 | EEG with generalized epileptiform discharges (HP:0011198) | 2.37799077 |
| 59 | Protruding tongue (HP:0010808) | 2.34911223 |
| 60 | Fetal akinesia sequence (HP:0001989) | 2.34874496 |
| 61 | Abnormal pupillary function (HP:0007686) | 2.34161194 |
| 62 | Mutism (HP:0002300) | 2.34005510 |
| 63 | Mitochondrial inheritance (HP:0001427) | 2.31662621 |
| 64 | Heterochromia iridis (HP:0001100) | 2.30989308 |
| 65 | Gait imbalance (HP:0002141) | 2.29900995 |
| 66 | Cerebral hemorrhage (HP:0001342) | 2.28856278 |
| 67 | Decreased lacrimation (HP:0000633) | 2.28838306 |
| 68 | Scanning speech (HP:0002168) | 2.27255791 |
| 69 | Craniofacial dystonia (HP:0012179) | 2.27255550 |
| 70 | Hemiplegia (HP:0002301) | 2.26267237 |
| 71 | Ankle clonus (HP:0011448) | 2.25761368 |
| 72 | Hypoventilation (HP:0002791) | 2.23647828 |
| 73 | Akinesia (HP:0002304) | 2.23145196 |
| 74 | Lower limb muscle weakness (HP:0007340) | 2.22615568 |
| 75 | Genital tract atresia (HP:0001827) | 2.20103626 |
| 76 | Vaginal atresia (HP:0000148) | 2.19956346 |
| 77 | Hypothermia (HP:0002045) | 2.18874595 |
| 78 | Partial duplication of thumb phalanx (HP:0009944) | 2.18798766 |
| 79 | Megalencephaly (HP:0001355) | 2.17648494 |
| 80 | Abnormality of the corticospinal tract (HP:0002492) | 2.17524180 |
| 81 | Genetic anticipation (HP:0003743) | 2.17344801 |
| 82 | Bradykinesia (HP:0002067) | 2.16503006 |
| 83 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.13544575 |
| 84 | Absent/shortened dynein arms (HP:0200106) | 2.13544575 |
| 85 | Hypsarrhythmia (HP:0002521) | 2.13522680 |
| 86 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.12969126 |
| 87 | Intention tremor (HP:0002080) | 2.10863235 |
| 88 | Partial duplication of the phalanx of hand (HP:0009999) | 2.10635929 |
| 89 | Impaired smooth pursuit (HP:0007772) | 2.09809858 |
| 90 | Shoulder girdle muscle weakness (HP:0003547) | 2.09630868 |
| 91 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.08960244 |
| 92 | Stereotypic behavior (HP:0000733) | 2.08774211 |
| 93 | Acute encephalopathy (HP:0006846) | 2.08420254 |
| 94 | Blue irides (HP:0000635) | 2.07926524 |
| 95 | Annular pancreas (HP:0001734) | 2.07498801 |
| 96 | Impaired vibratory sensation (HP:0002495) | 2.03563514 |
| 97 | Abnormality of incisor morphology (HP:0011063) | 2.03060250 |
| 98 | Psychosis (HP:0000709) | 2.02870119 |
| 99 | Generalized myoclonic seizures (HP:0002123) | 2.02669374 |
| 100 | Spastic gait (HP:0002064) | 2.01990504 |
| 101 | Agitation (HP:0000713) | 2.01211531 |
| 102 | Insidious onset (HP:0003587) | 2.00935632 |
| 103 | Termporal pattern (HP:0011008) | 2.00935632 |
| 104 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.00616833 |
| 105 | Turricephaly (HP:0000262) | 1.99463406 |
| 106 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.99278555 |
| 107 | Esotropia (HP:0000565) | 1.98524276 |
| 108 | Abnormality of salivation (HP:0100755) | 1.98034481 |
| 109 | Mixed hearing impairment (HP:0000410) | 1.97893413 |
| 110 | Nonprogressive disorder (HP:0003680) | 1.96946798 |
| 111 | Gait ataxia (HP:0002066) | 1.96807821 |
| 112 | Recurrent corneal erosions (HP:0000495) | 1.96032439 |
| 113 | Status epilepticus (HP:0002133) | 1.93781715 |
| 114 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.93340837 |
| 115 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.93340837 |
| 116 | Retinal dysplasia (HP:0007973) | 1.92948077 |
| 117 | Congenital primary aphakia (HP:0007707) | 1.92051400 |
| 118 | Optic disc pallor (HP:0000543) | 1.91477340 |
| 119 | Medial flaring of the eyebrow (HP:0010747) | 1.90950614 |
| 120 | Exotropia (HP:0000577) | 1.90288156 |
| 121 | Fair hair (HP:0002286) | 1.89086307 |
| 122 | Abnormal ciliary motility (HP:0012262) | 1.88997778 |
| 123 | Hyperthyroidism (HP:0000836) | 1.88357299 |
| 124 | Cerebral hypomyelination (HP:0006808) | 1.88335772 |
| 125 | Clonus (HP:0002169) | 1.86475530 |
| 126 | Abnormality of the lower motor neuron (HP:0002366) | 1.85829928 |
| 127 | Torticollis (HP:0000473) | 1.85245802 |
| 128 | Urinary urgency (HP:0000012) | 1.84592031 |
| 129 | Postural tremor (HP:0002174) | 1.84301938 |
| 130 | Rigidity (HP:0002063) | 1.82334549 |
| 131 | Incomplete penetrance (HP:0003829) | 1.77787361 |
| 132 | Dysmetric saccades (HP:0000641) | 1.77410139 |
| 133 | Bronchomalacia (HP:0002780) | 1.75570579 |
| 134 | Spastic tetraparesis (HP:0001285) | 1.75117158 |
| 135 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.73967779 |
| 136 | Prolonged QT interval (HP:0001657) | 1.68596330 |
| 137 | Conical tooth (HP:0000698) | 1.67702376 |
| 138 | Increased circulating renin level (HP:0000848) | 1.65891085 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.33824604 |
| 2 | NTRK3 | 3.96156030 |
| 3 | PNCK | 3.43020497 |
| 4 | MAP3K9 | 3.28543658 |
| 5 | MAP3K12 | 3.20092216 |
| 6 | MAP3K4 | 2.91545720 |
| 7 | MARK1 | 2.76607605 |
| 8 | CASK | 2.71975915 |
| 9 | RIPK4 | 2.64644592 |
| 10 | MAP2K7 | 2.54144536 |
| 11 | MINK1 | 2.47793056 |
| 12 | NTRK2 | 2.11602157 |
| 13 | MAP2K4 | 2.09348621 |
| 14 | PLK2 | 1.92763973 |
| 15 | TNIK | 1.89950260 |
| 16 | GRK5 | 1.86668387 |
| 17 | DAPK2 | 1.75905168 |
| 18 | ARAF | 1.73890046 |
| 19 | SIK2 | 1.65071396 |
| 20 | NTRK1 | 1.57430384 |
| 21 | MAPKAPK5 | 1.57296757 |
| 22 | MAPK13 | 1.54074331 |
| 23 | PINK1 | 1.51845266 |
| 24 | CDK5 | 1.42332306 |
| 25 | CAMK2A | 1.40302223 |
| 26 | GRK7 | 1.38509141 |
| 27 | NME1 | 1.32484786 |
| 28 | PAK6 | 1.31298211 |
| 29 | KSR2 | 1.29462834 |
| 30 | DAPK1 | 1.29390953 |
| 31 | FGR | 1.29113590 |
| 32 | PRKD3 | 1.28925138 |
| 33 | FES | 1.28701794 |
| 34 | SGK2 | 1.28010897 |
| 35 | KSR1 | 1.27122327 |
| 36 | CAMK2B | 1.26952399 |
| 37 | PRKCG | 1.23414992 |
| 38 | CSNK1G2 | 1.22381124 |
| 39 | BMPR2 | 1.21423095 |
| 40 | UHMK1 | 1.18455768 |
| 41 | PTK2B | 1.14711648 |
| 42 | MAP3K13 | 1.13275916 |
| 43 | ADRBK2 | 1.05013156 |
| 44 | CSNK1G3 | 1.03266974 |
| 45 | CDK19 | 0.99784369 |
| 46 | PRKCH | 0.96602127 |
| 47 | CDK18 | 0.94465059 |
| 48 | CDK14 | 0.93928580 |
| 49 | STK39 | 0.93320725 |
| 50 | OXSR1 | 0.92794050 |
| 51 | CDK15 | 0.92392952 |
| 52 | SGK3 | 0.92011540 |
| 53 | LATS2 | 0.89475342 |
| 54 | CAMK2D | 0.89019294 |
| 55 | DYRK2 | 0.87800392 |
| 56 | CAMKK1 | 0.86411411 |
| 57 | GRK6 | 0.86035586 |
| 58 | DYRK1A | 0.81908604 |
| 59 | LIMK1 | 0.81060219 |
| 60 | CDK11A | 0.80783713 |
| 61 | TYRO3 | 0.79936768 |
| 62 | FGFR2 | 0.77864431 |
| 63 | PAK3 | 0.77117910 |
| 64 | CAMKK2 | 0.76197527 |
| 65 | CAMK1G | 0.75683076 |
| 66 | ROCK2 | 0.73008660 |
| 67 | WNK4 | 0.70615195 |
| 68 | CAMK2G | 0.70374691 |
| 69 | PHKG2 | 0.66078455 |
| 70 | PHKG1 | 0.66078455 |
| 71 | CAMK4 | 0.64724871 |
| 72 | RET | 0.64429271 |
| 73 | CSNK1G1 | 0.63416719 |
| 74 | BCR | 0.63293192 |
| 75 | STK11 | 0.62435453 |
| 76 | PRKCE | 0.62121800 |
| 77 | SGK1 | 0.61703651 |
| 78 | RAF1 | 0.61341621 |
| 79 | MUSK | 0.57818837 |
| 80 | LMTK2 | 0.57280797 |
| 81 | ALK | 0.57088821 |
| 82 | NEK6 | 0.56792165 |
| 83 | WNK3 | 0.56270946 |
| 84 | CAMK1 | 0.56069074 |
| 85 | ADRBK1 | 0.55780032 |
| 86 | RIPK1 | 0.52384218 |
| 87 | STK38 | 0.52223443 |
| 88 | WNK1 | 0.50919219 |
| 89 | CDC42BPA | 0.47634321 |
| 90 | MAPK12 | 0.47054318 |
| 91 | SGK494 | 0.46397291 |
| 92 | SGK223 | 0.46397291 |
| 93 | PRKCZ | 0.46154809 |
| 94 | PKN1 | 0.45837007 |
| 95 | ERBB2 | 0.45198795 |
| 96 | TNK2 | 0.44123407 |
| 97 | MAP3K2 | 0.43852136 |
| 98 | PRKACA | 0.43632973 |
| 99 | CSNK1E | 0.38517920 |
| 100 | FYN | 0.38414609 |
| 101 | PRKG1 | 0.38262411 |
| 102 | MKNK2 | 0.38144039 |
| 103 | PDK1 | 0.37924606 |
| 104 | BRAF | 0.37643509 |
| 105 | PRKCB | 0.37302178 |
| 106 | FER | 0.36529972 |
| 107 | CSNK1D | 0.36291740 |
| 108 | MAP3K6 | 0.36231554 |
| 109 | RPS6KA3 | 0.36175035 |
| 110 | MAPK10 | 0.35532622 |
| 111 | MARK2 | 0.35283513 |
| 112 | SIK3 | 0.34901445 |
| 113 | PRPF4B | 0.34111113 |
| 114 | DAPK3 | 0.33691761 |
| 115 | MAP2K1 | 0.33073087 |
| 116 | MOS | 0.32964563 |
| 117 | AKT3 | 0.32242503 |
| 118 | PRKCA | 0.31941460 |
| 119 | MAPK8 | 0.31143642 |
| 120 | GSK3B | 0.29701319 |
| 121 | MAPK4 | 0.27689581 |
| 122 | CSNK1A1L | 0.27484564 |
| 123 | BRSK1 | 0.26955877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.34908721 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.25068624 |
| 3 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.95002449 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.92622761 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 2.68728244 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.66178947 |
| 7 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.56717597 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.51992974 |
| 9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.47840795 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.44909445 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 2.43310015 |
| 12 | Cocaine addiction_Homo sapiens_hsa05030 | 2.39485771 |
| 13 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.34923147 |
| 14 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.29859855 |
| 15 | Olfactory transduction_Homo sapiens_hsa04740 | 2.25975816 |
| 16 | Parkinsons disease_Homo sapiens_hsa05012 | 2.18254092 |
| 17 | Taste transduction_Homo sapiens_hsa04742 | 2.07018855 |
| 18 | Salivary secretion_Homo sapiens_hsa04970 | 2.04998427 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.97886219 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.94372000 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.87862853 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.82660797 |
| 23 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.78692924 |
| 24 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.72854669 |
| 25 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.69821240 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.68341484 |
| 27 | Insulin secretion_Homo sapiens_hsa04911 | 1.66312891 |
| 28 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60205657 |
| 29 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.55618852 |
| 30 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.49651183 |
| 31 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.45838875 |
| 32 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.43184382 |
| 33 | Huntingtons disease_Homo sapiens_hsa05016 | 1.39585426 |
| 34 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.37526992 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.36843415 |
| 36 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.22262486 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.21835532 |
| 38 | Axon guidance_Homo sapiens_hsa04360 | 1.14653023 |
| 39 | Phototransduction_Homo sapiens_hsa04744 | 1.08088641 |
| 40 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.05711347 |
| 41 | Melanogenesis_Homo sapiens_hsa04916 | 1.05396191 |
| 42 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04362346 |
| 43 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.03330276 |
| 44 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.02347138 |
| 45 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.98714130 |
| 46 | Bile secretion_Homo sapiens_hsa04976 | 0.91009784 |
| 47 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89641019 |
| 48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.88786698 |
| 49 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.87853376 |
| 50 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.85584803 |
| 51 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.84209007 |
| 52 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.80808349 |
| 53 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.74329784 |
| 54 | Glioma_Homo sapiens_hsa05214 | 0.72671355 |
| 55 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.72373347 |
| 56 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.71242338 |
| 57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.69024736 |
| 58 | Alcoholism_Homo sapiens_hsa05034 | 0.68523087 |
| 59 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.68275033 |
| 60 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.68023109 |
| 61 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.67440874 |
| 62 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.63770998 |
| 63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.62922428 |
| 64 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.61947429 |
| 65 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59940230 |
| 66 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.59278701 |
| 67 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.58439722 |
| 68 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.57927247 |
| 69 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.57784897 |
| 70 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.54782566 |
| 71 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.54105535 |
| 72 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.53785616 |
| 73 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.53013205 |
| 74 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.51379776 |
| 75 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.49611201 |
| 76 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.46845005 |
| 77 | Prion diseases_Homo sapiens_hsa05020 | 0.44277002 |
| 78 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.41353996 |
| 79 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40212463 |
| 80 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39888290 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.39319556 |
| 82 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.39195580 |
| 83 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.37866173 |
| 84 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.36396151 |
| 85 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.36341556 |
| 86 | Melanoma_Homo sapiens_hsa05218 | 0.36042861 |
| 87 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35846185 |
| 88 | Tight junction_Homo sapiens_hsa04530 | 0.35474352 |
| 89 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.33893515 |
| 90 | Endometrial cancer_Homo sapiens_hsa05213 | 0.33123139 |
| 91 | Endocytosis_Homo sapiens_hsa04144 | 0.30880349 |
| 92 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30216151 |
| 93 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.30168464 |
| 94 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28734105 |
| 95 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28665906 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28660255 |
| 97 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.28631262 |
| 98 | Mineral absorption_Homo sapiens_hsa04978 | 0.27877577 |
| 99 | Phagosome_Homo sapiens_hsa04145 | 0.27733645 |
| 100 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.27608766 |
| 101 | Amoebiasis_Homo sapiens_hsa05146 | 0.27603250 |
| 102 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.27496638 |
| 103 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26772030 |
| 104 | Histidine metabolism_Homo sapiens_hsa00340 | 0.26656649 |
| 105 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.26045337 |
| 106 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.24570676 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24363704 |
| 108 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.23211899 |
| 109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.20969879 |
| 110 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.20116030 |
| 111 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.19487303 |
| 112 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.18459641 |
| 113 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.17704556 |
| 114 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.16760970 |
| 115 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.16167276 |
| 116 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.14459907 |
| 117 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.14256255 |
| 118 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.12750275 |
| 119 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.10067683 |

