AJAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.70157139
2neuron cell-cell adhesion (GO:0007158)6.25582684
3vocalization behavior (GO:0071625)5.78104340
4cellular potassium ion homeostasis (GO:0030007)5.47264806
5sodium ion export (GO:0071436)5.28819316
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20897542
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.17827657
8neuronal ion channel clustering (GO:0045161)5.06936544
9synaptic vesicle exocytosis (GO:0016079)5.03634666
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98598049
11protein localization to synapse (GO:0035418)4.77387099
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.68407520
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.57030322
14regulation of glutamate receptor signaling pathway (GO:1900449)4.55093779
15dopamine transport (GO:0015872)4.52280145
16locomotory exploration behavior (GO:0035641)4.51872409
17dopamine biosynthetic process (GO:0042416)4.51280338
18glutamate receptor signaling pathway (GO:0007215)4.44856703
19neuron recognition (GO:0008038)4.40344560
20glutamate secretion (GO:0014047)4.35975569
21exploration behavior (GO:0035640)4.27939436
22mating behavior (GO:0007617)4.22421559
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.20234474
24regulation of synaptic vesicle exocytosis (GO:2000300)4.17336492
25neuron-neuron synaptic transmission (GO:0007270)4.16685446
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13661948
27response to histamine (GO:0034776)4.13143909
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07864186
29presynaptic membrane assembly (GO:0097105)4.07086361
30behavioral response to cocaine (GO:0048148)4.06544359
31neurotransmitter secretion (GO:0007269)4.04328807
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00449451
33neuronal action potential propagation (GO:0019227)3.99975998
34synaptic vesicle maturation (GO:0016188)3.99109577
35synaptic transmission, dopaminergic (GO:0001963)3.92281384
36synaptic transmission, glutamatergic (GO:0035249)3.87074799
37dendritic spine morphogenesis (GO:0060997)3.86115677
38cerebellar granule cell differentiation (GO:0021707)3.84665738
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78895465
40presynaptic membrane organization (GO:0097090)3.77329304
41postsynaptic membrane organization (GO:0001941)3.75808796
42layer formation in cerebral cortex (GO:0021819)3.73872413
43L-amino acid import (GO:0043092)3.73510209
44cerebellar Purkinje cell differentiation (GO:0021702)3.73251346
45transmission of nerve impulse (GO:0019226)3.72771387
46potassium ion homeostasis (GO:0055075)3.71085687
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70303344
48regulation of synaptic vesicle transport (GO:1902803)3.69507227
49regulation of neuronal synaptic plasticity (GO:0048168)3.68447733
50neurotransmitter transport (GO:0006836)3.67320476
51cell communication by electrical coupling (GO:0010644)3.65991520
52cellular sodium ion homeostasis (GO:0006883)3.65743542
53catecholamine transport (GO:0051937)3.64291449
54prepulse inhibition (GO:0060134)3.63168053
55regulation of postsynaptic membrane potential (GO:0060078)3.62092103
56regulation of neurotransmitter levels (GO:0001505)3.61850659
57axon ensheathment in central nervous system (GO:0032291)3.61629622
58central nervous system myelination (GO:0022010)3.61629622
59regulation of synapse structural plasticity (GO:0051823)3.60292346
60axonal fasciculation (GO:0007413)3.59099284
61potassium ion import (GO:0010107)3.58992029
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57938647
63regulation of catecholamine metabolic process (GO:0042069)3.57217688
64regulation of dopamine metabolic process (GO:0042053)3.57217688
65regulation of glutamate secretion (GO:0014048)3.56260609
66membrane depolarization during action potential (GO:0086010)3.54175837
67amino acid import (GO:0043090)3.54032047
68positive regulation of synapse assembly (GO:0051965)3.52382484
69regulation of vesicle fusion (GO:0031338)3.49083043
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48959382
71neurotransmitter-gated ion channel clustering (GO:0072578)3.47694650
72long-term memory (GO:0007616)3.47270502
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45178029
74positive regulation of dendritic spine development (GO:0060999)3.42176725
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42099880
76synapse assembly (GO:0007416)3.39776751
77regulation of neurotransmitter secretion (GO:0046928)3.38507338
78long-term synaptic potentiation (GO:0060291)3.35372346
79intraspecies interaction between organisms (GO:0051703)3.33620989
80social behavior (GO:0035176)3.33620989
81regulation of protein kinase A signaling (GO:0010738)3.32280483
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.32273882
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.32081037
84startle response (GO:0001964)3.31688398
85negative regulation of neurotransmitter transport (GO:0051589)3.31225384
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31180170
87auditory behavior (GO:0031223)3.27676688
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26379991
89synaptic vesicle endocytosis (GO:0048488)3.25795385
90neuromuscular process controlling balance (GO:0050885)3.25771736
91response to amphetamine (GO:0001975)3.24244843
92neuron remodeling (GO:0016322)3.23494803
93gamma-aminobutyric acid transport (GO:0015812)3.22639665
94serotonin metabolic process (GO:0042428)3.22485255
95positive regulation of membrane potential (GO:0045838)3.21066241
96regulation of dendritic spine morphogenesis (GO:0061001)3.20912032
97regulation of synapse maturation (GO:0090128)3.18168667
98striatum development (GO:0021756)3.17885496
99positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17800243
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16636658
101positive regulation of synapse maturation (GO:0090129)3.16073333
102regulation of voltage-gated calcium channel activity (GO:1901385)3.15296248
103regulation of neurotransmitter transport (GO:0051588)3.12513924
104cell migration in hindbrain (GO:0021535)3.10724056
105neurotransmitter catabolic process (GO:0042135)3.10036030
106membrane depolarization (GO:0051899)3.09885452
107cell communication involved in cardiac conduction (GO:0086065)3.09741384
108regulation of synaptic plasticity (GO:0048167)3.09251739
109positive regulation of neurotransmitter secretion (GO:0001956)3.09007633
110response to cocaine (GO:0042220)3.07515585
111detection of calcium ion (GO:0005513)3.07391300
112negative regulation of dendrite morphogenesis (GO:0050774)3.06875017
113innervation (GO:0060384)3.04601213
114membrane hyperpolarization (GO:0060081)3.04250201
115energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03721107
116ATP synthesis coupled proton transport (GO:0015986)3.03721107
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03647892
118establishment of synaptic vesicle localization (GO:0097480)3.03242033
119synaptic vesicle transport (GO:0048489)3.03242033
120learning (GO:0007612)3.03173107
121righting reflex (GO:0060013)3.02946189
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01377094
123behavioral defense response (GO:0002209)3.01329223
124behavioral fear response (GO:0001662)3.01329223
125regulation of dendritic spine development (GO:0060998)3.00940128
126positive regulation of neurotransmitter transport (GO:0051590)2.99678064
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98984026
128neurotransmitter uptake (GO:0001504)2.98579135
129cell differentiation in hindbrain (GO:0021533)2.92862126
130establishment of mitochondrion localization (GO:0051654)2.91642105
131neuromuscular process (GO:0050905)2.90235431
132neuromuscular synaptic transmission (GO:0007274)2.89402487
133central nervous system projection neuron axonogenesis (GO:0021952)2.89359738
134synaptic transmission (GO:0007268)2.89218161
135adult walking behavior (GO:0007628)2.87967118
136dendrite morphogenesis (GO:0048813)2.86951173
137negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78992483
138response to auditory stimulus (GO:0010996)2.77789132
139regulation of synaptic transmission (GO:0050804)2.77658198
140adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76485341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30669098
2GBX2_23144817_ChIP-Seq_PC3_Human3.95485034
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19677099
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17918078
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11389527
6TAF15_26573619_Chip-Seq_HEK293_Human2.83217440
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74095240
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67553888
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67553888
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.63896292
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60587553
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58694276
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57259918
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.52465894
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45625809
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45017155
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43562453
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.41004279
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35007293
20* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28867522
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20674598
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19667191
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19400784
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.10100711
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07185470
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.07138869
27DROSHA_22980978_ChIP-Seq_HELA_Human2.00166922
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.97573177
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.96792833
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87912256
31ZNF274_21170338_ChIP-Seq_K562_Hela1.83169206
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81557090
33SMAD4_21799915_ChIP-Seq_A2780_Human1.78164324
34P300_19829295_ChIP-Seq_ESCs_Human1.77702473
35* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73445848
36IGF1R_20145208_ChIP-Seq_DFB_Human1.71731929
37AR_21572438_ChIP-Seq_LNCaP_Human1.70721889
38VDR_22108803_ChIP-Seq_LS180_Human1.70529931
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.68648157
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68505895
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66016684
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59941925
43FUS_26573619_Chip-Seq_HEK293_Human1.57284649
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54971614
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53684003
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53084287
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50909273
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49118735
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48753987
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.48410668
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47031234
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.43162358
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41667533
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41132081
55RNF2_27304074_Chip-Seq_NSC_Mouse1.39711341
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39593266
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34623549
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32597718
59AR_25329375_ChIP-Seq_VCAP_Human1.31534732
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29072834
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.26455029
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25716501
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.25104220
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22519353
65ER_23166858_ChIP-Seq_MCF-7_Human1.21729826
66STAT3_23295773_ChIP-Seq_U87_Human1.17309115
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15825396
68RUNX2_22187159_ChIP-Seq_PCA_Human1.15669507
69JUN_21703547_ChIP-Seq_K562_Human1.14329318
70TP53_16413492_ChIP-PET_HCT116_Human1.14076533
71BCAT_22108803_ChIP-Seq_LS180_Human1.13751429
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.12377118
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08815524
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08766300
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08148744
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08018602
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.07958451
78TCF4_23295773_ChIP-Seq_U87_Human1.07299376
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06328779
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06198943
81* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05644498
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05631317
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05588602
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.05384386
85* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05140338
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05039234
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04453678
88* TP53_18474530_ChIP-ChIP_U2OS_Human1.03122480
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02741848
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02564583
91KDM2B_26808549_Chip-Seq_K562_Human1.02256716
92AR_19668381_ChIP-Seq_PC3_Human1.02021535
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01779074
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01208849
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01208849
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00576199
97* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00548156
98* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99734217
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99447962
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.97875106
101EP300_21415370_ChIP-Seq_HL-1_Mouse0.96997424
102EWS_26573619_Chip-Seq_HEK293_Human0.96971352
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96218650
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.96174088
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.96094437
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95342562
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94123409
108KDM2B_26808549_Chip-Seq_REH_Human0.93903132
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93803598
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93289454
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92273523
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92170313
113AHR_22903824_ChIP-Seq_MCF-7_Human0.91170407
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91107823
115* SOX9_26525672_Chip-Seq_HEART_Mouse0.90517591
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90106645
117* SMAD3_21741376_ChIP-Seq_ESCs_Human0.90086911
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89826839
119* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89810934
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89792880
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88613153
122* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88479348
123* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86050937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.43974575
2MP0004859_abnormal_synaptic_plasticity4.93721851
3MP0003635_abnormal_synaptic_transmissio3.88175713
4MP0009745_abnormal_behavioral_response3.40006839
5MP0006276_abnormal_autonomic_nervous3.22648982
6MP0001529_abnormal_vocalization3.19130268
7MP0002063_abnormal_learning/memory/cond3.12134741
8MP0002064_seizures3.07139582
9MP0009046_muscle_twitch3.03947864
10MP0001968_abnormal_touch/_nociception2.92883982
11MP0005423_abnormal_somatic_nervous2.90269225
12MP0002572_abnormal_emotion/affect_behav2.85426173
13MP0001501_abnormal_sleep_pattern2.84596855
14MP0004270_analgesia2.79097831
15MP0001905_abnormal_dopamine_level2.61385039
16MP0001486_abnormal_startle_reflex2.58317812
17MP0002272_abnormal_nervous_system2.56541586
18MP0003878_abnormal_ear_physiology2.49950620
19MP0005377_hearing/vestibular/ear_phenot2.49950620
20MP0002736_abnormal_nociception_after2.35520710
21MP0001440_abnormal_grooming_behavior2.33960478
22MP0002734_abnormal_mechanical_nocicepti2.30487073
23MP0002822_catalepsy2.22478958
24MP0000569_abnormal_digit_pigmentation2.12680098
25MP0002733_abnormal_thermal_nociception2.08242443
26MP0002067_abnormal_sensory_capabilities2.03749932
27MP0005386_behavior/neurological_phenoty2.03442252
28MP0004924_abnormal_behavior2.03442252
29MP0002184_abnormal_innervation1.99444115
30MP0003122_maternal_imprinting1.94098884
31MP0001970_abnormal_pain_threshold1.90822378
32MP0002735_abnormal_chemical_nociception1.89142570
33MP0000778_abnormal_nervous_system1.84965249
34MP0001188_hyperpigmentation1.81656935
35MP0002557_abnormal_social/conspecific_i1.79494656
36MP0001984_abnormal_olfaction1.68269518
37MP0003329_amyloid_beta_deposits1.59350772
38MP0002837_dystrophic_cardiac_calcinosis1.51762217
39MP0004142_abnormal_muscle_tone1.51645180
40MP0002909_abnormal_adrenal_gland1.50864687
41MP0002066_abnormal_motor_capabilities/c1.40874400
42MP0001502_abnormal_circadian_rhythm1.40121402
43MP0000955_abnormal_spinal_cord1.34113357
44MP0004811_abnormal_neuron_physiology1.32231621
45MP0008569_lethality_at_weaning1.31457168
46MP0004742_abnormal_vestibular_system1.31321493
47MP0000579_abnormal_nail_morphology1.31096201
48MP0005646_abnormal_pituitary_gland1.30228263
49MP0005409_darkened_coat_color1.29779469
50MP0002882_abnormal_neuron_morphology1.29577194
51MP0000566_synostosis1.24809805
52MP0005257_abnormal_intraocular_pressure1.23877440
53MP0005645_abnormal_hypothalamus_physiol1.22897821
54MP0003879_abnormal_hair_cell1.17930017
55MP0008872_abnormal_physiological_respon1.16938667
56MP0005535_abnormal_body_temperature1.14634508
57MP0004145_abnormal_muscle_electrophysio1.11262196
58MP0009780_abnormal_chondrocyte_physiolo1.10299384
59MP0001299_abnormal_eye_distance/1.03861975
60MP0000751_myopathy1.03366158
61MP0002152_abnormal_brain_morphology1.03046865
62MP0005551_abnormal_eye_electrophysiolog0.99879806
63MP0005248_abnormal_Harderian_gland0.99648703
64MP0009379_abnormal_foot_pigmentation0.97878482
65MP0003283_abnormal_digestive_organ0.95704092
66MP0003633_abnormal_nervous_system0.94803554
67MP0005499_abnormal_olfactory_system0.94643441
68MP0005394_taste/olfaction_phenotype0.94643441
69MP0003787_abnormal_imprinting0.92842590
70MP0003631_nervous_system_phenotype0.92637090
71MP0001664_abnormal_digestion0.92475910
72MP0000631_abnormal_neuroendocrine_gland0.89126982
73MP0002069_abnormal_eating/drinking_beha0.86714733
74MP0001963_abnormal_hearing_physiology0.86087768
75MP0002229_neurodegeneration0.85860690
76MP0004085_abnormal_heartbeat0.85781871
77MP0004858_abnormal_nervous_system0.85367273
78MP0004885_abnormal_endolymph0.83905972
79MP0002752_abnormal_somatic_nervous0.83078814
80MP0003938_abnormal_ear_development0.83011061
81MP0004133_heterotaxia0.82304334
82MP0002876_abnormal_thyroid_physiology0.82126971
83MP0008874_decreased_physiological_sensi0.82070291
84MP0010386_abnormal_urinary_bladder0.81663370
85MP0006072_abnormal_retinal_apoptosis0.79160597
86MP0002090_abnormal_vision0.76208132
87MP0003119_abnormal_digestive_system0.74723923
88MP0003632_abnormal_nervous_system0.74437574
89MP0000013_abnormal_adipose_tissue0.74071059
90MP0005379_endocrine/exocrine_gland_phen0.73347718
91MP0002102_abnormal_ear_morphology0.71935213
92MP0001346_abnormal_lacrimal_gland0.71021413
93MP0003634_abnormal_glial_cell0.68210732
94MP0003890_abnormal_embryonic-extraembry0.68151734
95MP0004043_abnormal_pH_regulation0.67785319
96MP0001177_atelectasis0.66364471
97MP0001943_abnormal_respiration0.65096368
98MP0003137_abnormal_impulse_conducting0.64253928
99MP0000026_abnormal_inner_ear0.63975565
100MP0000920_abnormal_myelination0.63747273
101MP0004484_altered_response_of0.63142554
102MP0000604_amyloidosis0.62985235
103MP0010769_abnormal_survival0.62297834
104MP0002332_abnormal_exercise_endurance0.61539853
105MP0003123_paternal_imprinting0.61104992
106MP0003121_genomic_imprinting0.60347528
107MP0004215_abnormal_myocardial_fiber0.60277219
108MP0001348_abnormal_lacrimal_gland0.60102935
109MP0002082_postnatal_lethality0.58912116
110MP0010768_mortality/aging0.58435996
111MP0005187_abnormal_penis_morphology0.57614268
112MP0000639_abnormal_adrenal_gland0.57180762
113MP0002638_abnormal_pupillary_reflex0.53587232
114MP0005623_abnormal_meninges_morphology0.53495742
115MP0005171_absent_coat_pigmentation0.52439675
116MP0003861_abnormal_nervous_system0.51885543
117MP0001485_abnormal_pinna_reflex0.51293991
118MP0002751_abnormal_autonomic_nervous0.51280962
119MP0003690_abnormal_glial_cell0.50516482
120MP0000538_abnormal_urinary_bladder0.50417840
121MP0010770_preweaning_lethality0.49142122

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.16966699
2Limb dystonia (HP:0002451)5.64343768
3Focal seizures (HP:0007359)5.50470179
4Visual hallucinations (HP:0002367)5.26824650
5Myokymia (HP:0002411)5.19389141
6Atonic seizures (HP:0010819)4.60086999
7Epileptic encephalopathy (HP:0200134)4.37811167
8Progressive cerebellar ataxia (HP:0002073)4.21876134
9Hyperventilation (HP:0002883)4.20674897
10Absence seizures (HP:0002121)4.15755465
11Febrile seizures (HP:0002373)4.02200121
12Broad-based gait (HP:0002136)3.89101927
13Dialeptic seizures (HP:0011146)3.87027688
14Cerebral inclusion bodies (HP:0100314)3.83878141
15Aplasia involving bones of the upper limbs (HP:0009823)3.82906081
16Aplasia of the phalanges of the hand (HP:0009802)3.82906081
17Aplasia involving bones of the extremities (HP:0009825)3.82906081
18Generalized tonic-clonic seizures (HP:0002069)3.73547505
19Postural instability (HP:0002172)3.52323659
20Neurofibrillary tangles (HP:0002185)3.39813451
21Amblyopia (HP:0000646)3.22760940
22Pheochromocytoma (HP:0002666)3.16119791
23Anxiety (HP:0000739)3.03832202
24Supranuclear gaze palsy (HP:0000605)3.00645215
25Papilledema (HP:0001085)2.90207539
26Acute necrotizing encephalopathy (HP:0006965)2.88982142
27Truncal ataxia (HP:0002078)2.88600469
28Excessive salivation (HP:0003781)2.86274843
29Drooling (HP:0002307)2.86274843
30Alacrima (HP:0000522)2.85749770
31Progressive inability to walk (HP:0002505)2.82614829
32Poor eye contact (HP:0000817)2.81946859
33Neuroendocrine neoplasm (HP:0100634)2.78801664
34Gaze-evoked nystagmus (HP:0000640)2.78385148
35Dysmetria (HP:0001310)2.67933373
36Progressive macrocephaly (HP:0004481)2.67748933
37Obstructive sleep apnea (HP:0002870)2.64457093
38Hemiparesis (HP:0001269)2.53846041
39Abnormal social behavior (HP:0012433)2.52571772
40Impaired social interactions (HP:0000735)2.52571772
41Polyphagia (HP:0002591)2.52524856
42Abnormal mitochondria in muscle tissue (HP:0008316)2.51389338
43Epileptiform EEG discharges (HP:0011182)2.51345063
44Inability to walk (HP:0002540)2.49112890
45Abnormal eating behavior (HP:0100738)2.49082816
46Action tremor (HP:0002345)2.48720746
47Impaired vibration sensation in the lower limbs (HP:0002166)2.48197822
48Delusions (HP:0000746)2.47047144
49Focal dystonia (HP:0004373)2.45864724
50Dysdiadochokinesis (HP:0002075)2.45356913
51Abnormality of binocular vision (HP:0011514)2.41633290
52Diplopia (HP:0000651)2.41633290
53Absent speech (HP:0001344)2.41410890
54Depression (HP:0000716)2.40607700
55Sleep apnea (HP:0010535)2.40082254
56Failure to thrive in infancy (HP:0001531)2.38654137
57Amyotrophic lateral sclerosis (HP:0007354)2.38477353
58EEG with generalized epileptiform discharges (HP:0011198)2.37799077
59Protruding tongue (HP:0010808)2.34911223
60Fetal akinesia sequence (HP:0001989)2.34874496
61Abnormal pupillary function (HP:0007686)2.34161194
62Mutism (HP:0002300)2.34005510
63Mitochondrial inheritance (HP:0001427)2.31662621
64Heterochromia iridis (HP:0001100)2.30989308
65Gait imbalance (HP:0002141)2.29900995
66Cerebral hemorrhage (HP:0001342)2.28856278
67Decreased lacrimation (HP:0000633)2.28838306
68Scanning speech (HP:0002168)2.27255791
69Craniofacial dystonia (HP:0012179)2.27255550
70Hemiplegia (HP:0002301)2.26267237
71Ankle clonus (HP:0011448)2.25761368
72Hypoventilation (HP:0002791)2.23647828
73Akinesia (HP:0002304)2.23145196
74Lower limb muscle weakness (HP:0007340)2.22615568
75Genital tract atresia (HP:0001827)2.20103626
76Vaginal atresia (HP:0000148)2.19956346
77Hypothermia (HP:0002045)2.18874595
78Partial duplication of thumb phalanx (HP:0009944)2.18798766
79Megalencephaly (HP:0001355)2.17648494
80Abnormality of the corticospinal tract (HP:0002492)2.17524180
81Genetic anticipation (HP:0003743)2.17344801
82Bradykinesia (HP:0002067)2.16503006
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.13544575
84Absent/shortened dynein arms (HP:0200106)2.13544575
85Hypsarrhythmia (HP:0002521)2.13522680
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12969126
87Intention tremor (HP:0002080)2.10863235
88Partial duplication of the phalanx of hand (HP:0009999)2.10635929
89Impaired smooth pursuit (HP:0007772)2.09809858
90Shoulder girdle muscle weakness (HP:0003547)2.09630868
91Urinary bladder sphincter dysfunction (HP:0002839)2.08960244
92Stereotypic behavior (HP:0000733)2.08774211
93Acute encephalopathy (HP:0006846)2.08420254
94Blue irides (HP:0000635)2.07926524
95Annular pancreas (HP:0001734)2.07498801
96Impaired vibratory sensation (HP:0002495)2.03563514
97Abnormality of incisor morphology (HP:0011063)2.03060250
98Psychosis (HP:0000709)2.02870119
99Generalized myoclonic seizures (HP:0002123)2.02669374
100Spastic gait (HP:0002064)2.01990504
101Agitation (HP:0000713)2.01211531
102Insidious onset (HP:0003587)2.00935632
103Termporal pattern (HP:0011008)2.00935632
104Morphological abnormality of the pyramidal tract (HP:0002062)2.00616833
105Turricephaly (HP:0000262)1.99463406
106Abnormality of ocular smooth pursuit (HP:0000617)1.99278555
107Esotropia (HP:0000565)1.98524276
108Abnormality of salivation (HP:0100755)1.98034481
109Mixed hearing impairment (HP:0000410)1.97893413
110Nonprogressive disorder (HP:0003680)1.96946798
111Gait ataxia (HP:0002066)1.96807821
112Recurrent corneal erosions (HP:0000495)1.96032439
113Status epilepticus (HP:0002133)1.93781715
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.93340837
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.93340837
116Retinal dysplasia (HP:0007973)1.92948077
117Congenital primary aphakia (HP:0007707)1.92051400
118Optic disc pallor (HP:0000543)1.91477340
119Medial flaring of the eyebrow (HP:0010747)1.90950614
120Exotropia (HP:0000577)1.90288156
121Fair hair (HP:0002286)1.89086307
122Abnormal ciliary motility (HP:0012262)1.88997778
123Hyperthyroidism (HP:0000836)1.88357299
124Cerebral hypomyelination (HP:0006808)1.88335772
125Clonus (HP:0002169)1.86475530
126Abnormality of the lower motor neuron (HP:0002366)1.85829928
127Torticollis (HP:0000473)1.85245802
128Urinary urgency (HP:0000012)1.84592031
129Postural tremor (HP:0002174)1.84301938
130Rigidity (HP:0002063)1.82334549
131Incomplete penetrance (HP:0003829)1.77787361
132Dysmetric saccades (HP:0000641)1.77410139
133Bronchomalacia (HP:0002780)1.75570579
134Spastic tetraparesis (HP:0001285)1.75117158
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73967779
136Prolonged QT interval (HP:0001657)1.68596330
137Conical tooth (HP:0000698)1.67702376
138Increased circulating renin level (HP:0000848)1.65891085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.33824604
2NTRK33.96156030
3PNCK3.43020497
4MAP3K93.28543658
5MAP3K123.20092216
6MAP3K42.91545720
7MARK12.76607605
8CASK2.71975915
9RIPK42.64644592
10MAP2K72.54144536
11MINK12.47793056
12NTRK22.11602157
13MAP2K42.09348621
14PLK21.92763973
15TNIK1.89950260
16GRK51.86668387
17DAPK21.75905168
18ARAF1.73890046
19SIK21.65071396
20NTRK11.57430384
21MAPKAPK51.57296757
22MAPK131.54074331
23PINK11.51845266
24CDK51.42332306
25CAMK2A1.40302223
26GRK71.38509141
27NME11.32484786
28PAK61.31298211
29KSR21.29462834
30DAPK11.29390953
31FGR1.29113590
32PRKD31.28925138
33FES1.28701794
34SGK21.28010897
35KSR11.27122327
36CAMK2B1.26952399
37PRKCG1.23414992
38CSNK1G21.22381124
39BMPR21.21423095
40UHMK11.18455768
41PTK2B1.14711648
42MAP3K131.13275916
43ADRBK21.05013156
44CSNK1G31.03266974
45CDK190.99784369
46PRKCH0.96602127
47CDK180.94465059
48CDK140.93928580
49STK390.93320725
50OXSR10.92794050
51CDK150.92392952
52SGK30.92011540
53LATS20.89475342
54CAMK2D0.89019294
55DYRK20.87800392
56CAMKK10.86411411
57GRK60.86035586
58DYRK1A0.81908604
59LIMK10.81060219
60CDK11A0.80783713
61TYRO30.79936768
62FGFR20.77864431
63PAK30.77117910
64CAMKK20.76197527
65CAMK1G0.75683076
66ROCK20.73008660
67WNK40.70615195
68CAMK2G0.70374691
69PHKG20.66078455
70PHKG10.66078455
71CAMK40.64724871
72RET0.64429271
73CSNK1G10.63416719
74BCR0.63293192
75STK110.62435453
76PRKCE0.62121800
77SGK10.61703651
78RAF10.61341621
79MUSK0.57818837
80LMTK20.57280797
81ALK0.57088821
82NEK60.56792165
83WNK30.56270946
84CAMK10.56069074
85ADRBK10.55780032
86RIPK10.52384218
87STK380.52223443
88WNK10.50919219
89CDC42BPA0.47634321
90MAPK120.47054318
91SGK4940.46397291
92SGK2230.46397291
93PRKCZ0.46154809
94PKN10.45837007
95ERBB20.45198795
96TNK20.44123407
97MAP3K20.43852136
98PRKACA0.43632973
99CSNK1E0.38517920
100FYN0.38414609
101PRKG10.38262411
102MKNK20.38144039
103PDK10.37924606
104BRAF0.37643509
105PRKCB0.37302178
106FER0.36529972
107CSNK1D0.36291740
108MAP3K60.36231554
109RPS6KA30.36175035
110MAPK100.35532622
111MARK20.35283513
112SIK30.34901445
113PRPF4B0.34111113
114DAPK30.33691761
115MAP2K10.33073087
116MOS0.32964563
117AKT30.32242503
118PRKCA0.31941460
119MAPK80.31143642
120GSK3B0.29701319
121MAPK40.27689581
122CSNK1A1L0.27484564
123BRSK10.26955877

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.34908721
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25068624
3Amphetamine addiction_Homo sapiens_hsa050312.95002449
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92622761
5Long-term potentiation_Homo sapiens_hsa047202.68728244
6GABAergic synapse_Homo sapiens_hsa047272.66178947
7Oxidative phosphorylation_Homo sapiens_hsa001902.56717597
8Glutamatergic synapse_Homo sapiens_hsa047242.51992974
9Circadian entrainment_Homo sapiens_hsa047132.47840795
10Dopaminergic synapse_Homo sapiens_hsa047282.44909445
11Morphine addiction_Homo sapiens_hsa050322.43310015
12Cocaine addiction_Homo sapiens_hsa050302.39485771
13Collecting duct acid secretion_Homo sapiens_hsa049662.34923147
14Serotonergic synapse_Homo sapiens_hsa047262.29859855
15Olfactory transduction_Homo sapiens_hsa047402.25975816
16Parkinsons disease_Homo sapiens_hsa050122.18254092
17Taste transduction_Homo sapiens_hsa047422.07018855
18Salivary secretion_Homo sapiens_hsa049702.04998427
19Alzheimers disease_Homo sapiens_hsa050101.97886219
20Renin secretion_Homo sapiens_hsa049241.94372000
21Long-term depression_Homo sapiens_hsa047301.87862853
22Cholinergic synapse_Homo sapiens_hsa047251.82660797
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78692924
24Cardiac muscle contraction_Homo sapiens_hsa042601.72854669
25Gastric acid secretion_Homo sapiens_hsa049711.69821240
26Calcium signaling pathway_Homo sapiens_hsa040201.68341484
27Insulin secretion_Homo sapiens_hsa049111.66312891
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60205657
29Oxytocin signaling pathway_Homo sapiens_hsa049211.55618852
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49651183
31Vibrio cholerae infection_Homo sapiens_hsa051101.45838875
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43184382
33Huntingtons disease_Homo sapiens_hsa050161.39585426
34GnRH signaling pathway_Homo sapiens_hsa049121.37526992
35Gap junction_Homo sapiens_hsa045401.36843415
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22262486
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21835532
38Axon guidance_Homo sapiens_hsa043601.14653023
39Phototransduction_Homo sapiens_hsa047441.08088641
40Estrogen signaling pathway_Homo sapiens_hsa049151.05711347
41Melanogenesis_Homo sapiens_hsa049161.05396191
42Vitamin B6 metabolism_Homo sapiens_hsa007501.04362346
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03330276
44Nitrogen metabolism_Homo sapiens_hsa009101.02347138
45cAMP signaling pathway_Homo sapiens_hsa040240.98714130
46Bile secretion_Homo sapiens_hsa049760.91009784
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.89641019
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88786698
49African trypanosomiasis_Homo sapiens_hsa051430.87853376
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85584803
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84209007
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80808349
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74329784
54Glioma_Homo sapiens_hsa052140.72671355
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72373347
56Oocyte meiosis_Homo sapiens_hsa041140.71242338
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69024736
58Alcoholism_Homo sapiens_hsa050340.68523087
59Pancreatic secretion_Homo sapiens_hsa049720.68275033
60ErbB signaling pathway_Homo sapiens_hsa040120.68023109
61Thyroid hormone synthesis_Homo sapiens_hsa049180.67440874
62Type II diabetes mellitus_Homo sapiens_hsa049300.63770998
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62922428
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61947429
65Rheumatoid arthritis_Homo sapiens_hsa053230.59940230
66Dilated cardiomyopathy_Homo sapiens_hsa054140.59278701
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58439722
68Dorso-ventral axis formation_Homo sapiens_hsa043200.57927247
69Hippo signaling pathway_Homo sapiens_hsa043900.57784897
70Glucagon signaling pathway_Homo sapiens_hsa049220.54782566
71MAPK signaling pathway_Homo sapiens_hsa040100.54105535
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.53785616
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53013205
74Choline metabolism in cancer_Homo sapiens_hsa052310.51379776
75Protein digestion and absorption_Homo sapiens_hsa049740.49611201
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46845005
77Prion diseases_Homo sapiens_hsa050200.44277002
78Wnt signaling pathway_Homo sapiens_hsa043100.41353996
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40212463
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39888290
81VEGF signaling pathway_Homo sapiens_hsa043700.39319556
82Ras signaling pathway_Homo sapiens_hsa040140.39195580
83ECM-receptor interaction_Homo sapiens_hsa045120.37866173
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36396151
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.36341556
86Melanoma_Homo sapiens_hsa052180.36042861
87Circadian rhythm_Homo sapiens_hsa047100.35846185
88Tight junction_Homo sapiens_hsa045300.35474352
89Rap1 signaling pathway_Homo sapiens_hsa040150.33893515
90Endometrial cancer_Homo sapiens_hsa052130.33123139
91Endocytosis_Homo sapiens_hsa041440.30880349
92Tyrosine metabolism_Homo sapiens_hsa003500.30216151
93Phenylalanine metabolism_Homo sapiens_hsa003600.30168464
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28734105
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28665906
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28660255
97Basal cell carcinoma_Homo sapiens_hsa052170.28631262
98Mineral absorption_Homo sapiens_hsa049780.27877577
99Phagosome_Homo sapiens_hsa041450.27733645
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27608766
101Amoebiasis_Homo sapiens_hsa051460.27603250
102Inositol phosphate metabolism_Homo sapiens_hsa005620.27496638
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26772030
104Histidine metabolism_Homo sapiens_hsa003400.26656649
105Type I diabetes mellitus_Homo sapiens_hsa049400.26045337
106mTOR signaling pathway_Homo sapiens_hsa041500.24570676
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24363704
108Renal cell carcinoma_Homo sapiens_hsa052110.23211899
109Ovarian steroidogenesis_Homo sapiens_hsa049130.20969879
110Hedgehog signaling pathway_Homo sapiens_hsa043400.20116030
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19487303
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18459641
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.17704556
114Butanoate metabolism_Homo sapiens_hsa006500.16760970
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.16167276
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14459907
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14256255
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12750275
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10067683

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »