AK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)8.24216542
2actin-myosin filament sliding (GO:0033275)8.24216542
3sarcomere organization (GO:0045214)7.77069830
4response to muscle activity (GO:0014850)7.49001958
5actin-mediated cell contraction (GO:0070252)6.86245941
6cardiac myofibril assembly (GO:0055003)6.77388546
7regulation of skeletal muscle contraction (GO:0014819)6.74651510
8plasma membrane repair (GO:0001778)6.69651722
9myofibril assembly (GO:0030239)6.66232057
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.60832723
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.40506182
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.02490736
13sarcoplasmic reticulum calcium ion transport (GO:0070296)5.80875967
14cardiac muscle contraction (GO:0060048)5.76908027
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.73782615
16tricarboxylic acid cycle (GO:0006099)5.44489514
17striated muscle contraction (GO:0006941)5.38266082
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.32305771
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.31320580
20actomyosin structure organization (GO:0031032)5.22598832
21regulation of cell communication by electrical coupling (GO:0010649)5.10417108
22actin filament-based movement (GO:0030048)5.08051651
23regulation of relaxation of muscle (GO:1901077)5.07020399
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.04423223
25cardiac muscle cell development (GO:0055013)5.00055870
26skeletal muscle fiber development (GO:0048741)4.88084491
27skeletal muscle contraction (GO:0003009)4.86965233
28regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.79769531
29cardiac cell development (GO:0055006)4.67559293
30regulation of actin filament-based movement (GO:1903115)4.66323948
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.65423843
32cardiac muscle tissue morphogenesis (GO:0055008)4.55559082
33myotube cell development (GO:0014904)4.45329855
34regulation of membrane repolarization (GO:0060306)4.37976719
35regulation of acyl-CoA biosynthetic process (GO:0050812)4.36751699
36heart process (GO:0003015)4.27717931
37heart contraction (GO:0060047)4.27717931
38regulation of striated muscle contraction (GO:0006942)4.26927662
39muscle tissue morphogenesis (GO:0060415)4.18429390
40cardiac muscle hypertrophy (GO:0003300)4.17631385
41ventricular cardiac muscle cell action potential (GO:0086005)4.13550031
42adult heart development (GO:0007512)4.13489111
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.10474793
44regulation of coenzyme metabolic process (GO:0051196)4.09467345
45regulation of cofactor metabolic process (GO:0051193)4.09467345
46striated muscle hypertrophy (GO:0014897)4.05463732
47carnitine shuttle (GO:0006853)4.05011576
48response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.04179983
49muscle contraction (GO:0006936)3.96267014
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91366545
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87415509
52regulation of sarcomere organization (GO:0060297)3.83235341
53heart trabecula formation (GO:0060347)3.80169326
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68205937
55positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.63741092
56negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.62220128
57regulation of calcium ion transmembrane transporter activity (GO:1901019)3.60048513
58regulation of calcium ion transmembrane transport (GO:1903169)3.60048513
59muscle system process (GO:0003012)3.59789805
60response to inactivity (GO:0014854)3.59653349
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57177120
62skeletal muscle tissue development (GO:0007519)3.57137464
63cell communication involved in cardiac conduction (GO:0086065)3.55244936
64muscle cell fate commitment (GO:0042693)3.53762703
65regulation of the force of heart contraction (GO:0002026)3.50630820
66muscle hypertrophy (GO:0014896)3.50514362
67striated muscle cell development (GO:0055002)3.49059621
68negative regulation of protein localization to cell surface (GO:2000009)3.48906480
69regulation of myoblast differentiation (GO:0045661)3.48617303
70cell communication by electrical coupling (GO:0010644)3.48509683
71NADH metabolic process (GO:0006734)3.47706093
72cardiac muscle cell action potential involved in contraction (GO:0086002)3.47053841
73negative regulation of calcium ion transmembrane transport (GO:1903170)3.45253105
74negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.45253105
75cardiac muscle cell action potential (GO:0086001)3.41975887
76motile cilium assembly (GO:0044458)3.41053658
77negative regulation of potassium ion transport (GO:0043267)3.39451410
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38464306
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37494902
80ATP synthesis coupled proton transport (GO:0015986)3.37494902
81muscle organ development (GO:0007517)3.36716028
82regulation of heart rate (GO:0002027)3.36212400
83muscle structure development (GO:0061061)3.32461041
84skeletal muscle adaptation (GO:0043501)3.32261917
85detection of calcium ion (GO:0005513)3.28041088
86oxidative phosphorylation (GO:0006119)3.27505338
87axonemal dynein complex assembly (GO:0070286)3.26809137
88muscle fiber development (GO:0048747)3.25417973
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25019012
90respiratory electron transport chain (GO:0022904)3.22789424
91creatine metabolic process (GO:0006600)3.22080515
92glycogen catabolic process (GO:0005980)3.21696917
93fatty acid transmembrane transport (GO:1902001)3.21167558
94muscle cell cellular homeostasis (GO:0046716)3.20807881
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20481177
96negative regulation of striated muscle cell apoptotic process (GO:0010664)3.19842725
97glucan catabolic process (GO:0009251)3.19603443
98regulation of cardiac muscle contraction (GO:0055117)3.18042854
99electron transport chain (GO:0022900)3.15976773
100bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14012143
101positive regulation of cation channel activity (GO:2001259)3.13372509
102regulation of heart rate by cardiac conduction (GO:0086091)3.12966070
103cardiac conduction (GO:0061337)3.12355277
104response to activity (GO:0014823)3.11868391
105cardiac muscle adaptation (GO:0014887)3.11789154
106cardiac muscle hypertrophy in response to stress (GO:0014898)3.11789154
107muscle hypertrophy in response to stress (GO:0003299)3.11789154
108regulation of ATPase activity (GO:0043462)3.10561097
109regulation of ATP catabolic process (GO:1903289)3.10561097
110regulation of muscle contraction (GO:0006937)3.09668871
111glucan biosynthetic process (GO:0009250)3.09488176
112glycogen biosynthetic process (GO:0005978)3.09488176
113striated muscle adaptation (GO:0014888)3.09352449
114pyrimidine ribonucleoside catabolic process (GO:0046133)3.08468165
115regulation of oxidative phosphorylation (GO:0002082)3.07812816
116striated muscle atrophy (GO:0014891)3.06422944
117regulation of heart contraction (GO:0008016)3.04609435
118regulation of sulfur metabolic process (GO:0042762)3.04315278
119positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.03555872
120neuromuscular synaptic transmission (GO:0007274)3.02861485
121regulation of striated muscle cell apoptotic process (GO:0010662)2.98061909
122positive regulation of catecholamine secretion (GO:0033605)2.96747955
123muscle atrophy (GO:0014889)2.95621702
124gluconeogenesis (GO:0006094)2.94205712
125cellular polysaccharide catabolic process (GO:0044247)2.89906511
126relaxation of muscle (GO:0090075)2.88502253
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88093058
128glycogen metabolic process (GO:0005977)2.87375632
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86804794
130muscle cell development (GO:0055001)2.84299026
131regulation of muscle system process (GO:0090257)2.79652257
132glucan metabolic process (GO:0044042)2.79373256
133cellular glucan metabolic process (GO:0006073)2.79373256
134regulation of potassium ion transmembrane transporter activity (GO:1901016)2.78301467
135regulation of skeletal muscle fiber development (GO:0048742)2.75141128
136myoblast fusion (GO:0007520)2.73304226
137response to mercury ion (GO:0046689)2.73049997
138muscle adaptation (GO:0043500)2.69308337
139hexose biosynthetic process (GO:0019319)2.69111397
140striated muscle tissue development (GO:0014706)2.68044080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29268241
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.78228243
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.54562603
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96569571
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.83585678
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82369795
7* TBX20_22328084_ChIP-Seq_HEART_Mouse2.55859460
8* TBX20_22080862_ChIP-Seq_HEART_Mouse2.55859460
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.51310051
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.29009845
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14293773
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.06386803
13ZNF263_19887448_ChIP-Seq_K562_Human1.84088906
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82106793
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80793092
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79677416
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79677416
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73260476
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72499547
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71266808
21DROSHA_22980978_ChIP-Seq_HELA_Human1.71217821
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69326151
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63886431
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61633717
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.61218164
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60756971
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55492901
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.52542254
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51104211
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.49348832
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.46710862
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43267086
33ZNF274_21170338_ChIP-Seq_K562_Hela1.41450205
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41280248
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39153080
36* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.39131345
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39089933
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38642180
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36157306
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34609275
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34423941
42* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.33214997
43CTCF_27219007_Chip-Seq_Bcells_Human1.32891786
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31913430
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30812610
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28572448
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27054808
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26401385
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23900048
50* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23153275
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.22940075
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.21631974
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21171772
54* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20142047
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19791730
56* TP53_23651856_ChIP-Seq_MEFs_Mouse1.19617451
57* TP53_20018659_ChIP-ChIP_R1E_Mouse1.19161514
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19150858
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.18313118
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18173990
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.17945700
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.16749355
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.16231400
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15500956
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15292481
66GBX2_23144817_ChIP-Seq_PC3_Human1.14671853
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13851578
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09923933
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07576197
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06962883
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.06470401
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05221204
73CJUN_26792858_Chip-Seq_BT549_Human1.05180147
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04496129
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04071431
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.03554233
77* SMC4_20622854_ChIP-Seq_HELA_Human1.02857699
78NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00725588
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00642289
80KDM2B_26808549_Chip-Seq_K562_Human1.00101052
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.99560502
82SA1_27219007_Chip-Seq_Bcells_Human0.99269402
83ISL1_27105846_Chip-Seq_CPCs_Mouse0.98697035
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98020806
85* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97422895
86DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96860822
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95858647
88WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95471394
89* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95466126
90P68_20966046_ChIP-Seq_HELA_Human0.94167913
91STAT1_20625510_ChIP-Seq_HELA_Human0.93924220
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93093596
93TP63_22573176_ChIP-Seq_HFKS_Human0.92724873
94MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92600093
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92234785
96OCT4_20526341_ChIP-Seq_ESCs_Human0.91101649
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.90741854
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90507920
99SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90104006
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89880192
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.88128065
102* ELF1_20517297_ChIP-Seq_JURKAT_Human0.87845098
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87082627
104HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86674759
105SPI1_20517297_ChIP-Seq_HL60_Human0.86620972
106AHR_22903824_ChIP-Seq_MCF-7_Human0.86441662
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86349167
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85754195
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85754195
110SMAD4_21799915_ChIP-Seq_A2780_Human0.85728279
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.85661183
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84442202
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.83931455
114CLOCK_20551151_ChIP-Seq_293T_Human0.82662036
115REST_21632747_ChIP-Seq_MESCs_Mouse0.82505339
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82505299
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81628007
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.81531831
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81491515
120AR_19668381_ChIP-Seq_PC3_Human0.81197073
121* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80918249
122VDR_22108803_ChIP-Seq_LS180_Human0.80244024
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80058099
124IGF1R_20145208_ChIP-Seq_DFB_Human0.80003538
125RACK7_27058665_Chip-Seq_MCF-7_Human0.79965484
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79506480
127NANOG_20526341_ChIP-Seq_ESCs_Human0.78749013
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78430503
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77899739
130LXR_22292898_ChIP-Seq_THP-1_Human0.77828303
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77741107
132CTCF_21964334_Chip-Seq_Bcells_Human0.77704774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.72819739
2MP0000751_myopathy5.24125543
3MP0003646_muscle_fatigue5.11075579
4MP0000749_muscle_degeneration4.79087099
5MP0004084_abnormal_cardiac_muscle4.55539744
6MP0004036_abnormal_muscle_relaxation4.10003314
7MP0004145_abnormal_muscle_electrophysio3.86846115
8MP0004215_abnormal_myocardial_fiber3.51738366
9MP0005330_cardiomyopathy3.09282425
10MP0004087_abnormal_muscle_fiber3.04541304
11MP0002106_abnormal_muscle_physiology2.84356027
12MP0000750_abnormal_muscle_regeneration2.78958542
13* MP0005620_abnormal_muscle_contractility2.74163930
14MP0002269_muscular_atrophy2.65564501
15MP0000747_muscle_weakness2.61452918
16MP0002972_abnormal_cardiac_muscle2.59883701
17MP0000759_abnormal_skeletal_muscle2.53078566
18MP0005369_muscle_phenotype2.43022888
19MP0004233_abnormal_muscle_weight2.31485144
20MP0003137_abnormal_impulse_conducting2.28971988
21MP0008775_abnormal_heart_ventricle2.24374138
22MP0004130_abnormal_muscle_cell2.20874570
23MP0004484_altered_response_of2.01549012
24MP0005451_abnormal_body_composition2.00380037
25MP0010630_abnormal_cardiac_muscle1.97754135
26MP0001544_abnormal_cardiovascular_syste1.93803686
27MP0005385_cardiovascular_system_phenoty1.93803686
28MP0006138_congestive_heart_failure1.77643387
29MP0004085_abnormal_heartbeat1.71365316
30MP0008438_abnormal_cutaneous_collagen1.68814717
31MP0002332_abnormal_exercise_endurance1.66214233
32MP0003221_abnormal_cardiomyocyte_apopto1.50255580
33MP0003279_aneurysm1.43432297
34MP0002108_abnormal_muscle_morphology1.42970551
35MP0002127_abnormal_cardiovascular_syste1.37965309
36MP0005275_abnormal_skin_tensile1.35486105
37MP0003950_abnormal_plasma_membrane1.35322889
38* MP0006036_abnormal_mitochondrial_physio1.33162898
39MP0005623_abnormal_meninges_morphology1.32771804
40MP0000013_abnormal_adipose_tissue1.25832765
41MP0003828_pulmonary_edema1.23726608
42MP0010030_abnormal_orbit_morphology1.20768282
43MP0003705_abnormal_hypodermis_morpholog1.20268196
44MP0004270_analgesia1.17871358
45MP0003879_abnormal_hair_cell1.17269501
46MP0005503_abnormal_tendon_morphology1.11056223
47MP0004510_myositis1.10949546
48MP0000733_abnormal_muscle_development1.06160454
49MP0006035_abnormal_mitochondrial_morpho1.04873458
50MP0002234_abnormal_pharynx_morphology1.03206674
51MP0004859_abnormal_synaptic_plasticity1.00128035
52MP0001984_abnormal_olfaction0.99832731
53MP0004858_abnormal_nervous_system0.93755349
54MP0000266_abnormal_heart_morphology0.93054689
55MP0005666_abnormal_adipose_tissue0.92859087
56MP0009840_abnormal_foam_cell0.85140981
57MP0001661_extended_life_span0.83683080
58MP0005375_adipose_tissue_phenotype0.79844558
59MP0001529_abnormal_vocalization0.79762024
60MP0001299_abnormal_eye_distance/0.75139675
61MP0000003_abnormal_adipose_tissue0.74028839
62MP0001905_abnormal_dopamine_level0.69866165
63MP0006276_abnormal_autonomic_nervous0.69755112
64MP0005165_increased_susceptibility_to0.69741337
65MP0004185_abnormal_adipocyte_glucose0.69520479
66MP0004272_abnormal_basement_membrane0.68861061
67MP0002909_abnormal_adrenal_gland0.68164796
68MP0002822_catalepsy0.66722651
69MP0005670_abnormal_white_adipose0.66197879
70MP0003567_abnormal_fetal_cardiomyocyte0.65857534
71MP0003566_abnormal_cell_adhesion0.65135300
72MP0005423_abnormal_somatic_nervous0.64489376
73MP0000230_abnormal_systemic_arterial0.62093614
74MP0009780_abnormal_chondrocyte_physiolo0.62015005
75MP0001958_emphysema0.59725193
76MP0003635_abnormal_synaptic_transmissio0.59137014
77MP0008004_abnormal_stomach_pH0.58590066
78* MP0005266_abnormal_metabolism0.58196482
79MP0002128_abnormal_blood_circulation0.57780699
80MP0008569_lethality_at_weaning0.56059280
81MP0008789_abnormal_olfactory_epithelium0.55839839
82MP0002734_abnormal_mechanical_nocicepti0.54936215
83MP0003136_yellow_coat_color0.54732076
84MP0001879_abnormal_lymphatic_vessel0.51506067
85MP0004043_abnormal_pH_regulation0.51351987
86MP0002877_abnormal_melanocyte_morpholog0.51349531
87MP0009384_cardiac_valve_regurgitation0.50871123
88MP0001542_abnormal_bone_strength0.50385565
89MP0009250_abnormal_appendicular_skeleto0.49214752
90MP0010368_abnormal_lymphatic_system0.48122580
91MP0002249_abnormal_larynx_morphology0.47100633
92MP0002160_abnormal_reproductive_system0.46934261
93MP0003385_abnormal_body_wall0.46769200
94MP0002066_abnormal_motor_capabilities/c0.46743375
95MP0009046_muscle_twitch0.46217299
96MP0005058_abnormal_lysosome_morphology0.44855188
97MP0002638_abnormal_pupillary_reflex0.44485616
98MP0001502_abnormal_circadian_rhythm0.44327260
99MP0002896_abnormal_bone_mineralization0.44224001
100MP0004142_abnormal_muscle_tone0.44173417
101MP0000767_abnormal_smooth_muscle0.43961802
102MP0002272_abnormal_nervous_system0.43361219
103MP0001440_abnormal_grooming_behavior0.42833653
104MP0008961_abnormal_basal_metabolism0.42569583
105MP0002132_abnormal_respiratory_system0.42380198
106MP0002184_abnormal_innervation0.41715422
107MP0000762_abnormal_tongue_morphology0.41686457
108* MP0000343_altered_response_to0.41667781
109MP0003283_abnormal_digestive_organ0.41316938
110MP0002971_abnormal_brown_adipose0.41173855
111MP0003122_maternal_imprinting0.40242401
112MP0005386_behavior/neurological_phenoty0.39542893
113MP0004924_abnormal_behavior0.39542893
114MP0002295_abnormal_pulmonary_circulatio0.39324529
115MP0002067_abnormal_sensory_capabilities0.39169221
116MP0002063_abnormal_learning/memory/cond0.39065618
117MP0003315_abnormal_perineum_morphology0.38412194
118MP0005166_decreased_susceptibility_to0.38131166
119MP0009745_abnormal_behavioral_response0.36832285
120MP0003948_abnormal_gas_homeostasis0.36779793
121MP0002925_abnormal_cardiovascular_devel0.36744899
122MP0002735_abnormal_chemical_nociception0.36519885
123MP0002064_seizures0.35901892
124MP0005595_abnormal_vascular_smooth0.35787170
125MP0005187_abnormal_penis_morphology0.35670397

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.95975932
2Exercise-induced muscle cramps (HP:0003710)6.76498368
3Calf muscle hypertrophy (HP:0008981)6.38460095
4Muscle hypertrophy of the lower extremities (HP:0008968)6.31720414
5Sudden death (HP:0001699)6.24222748
6Muscle fiber splitting (HP:0003555)5.37068252
7Abnormality of the calf musculature (HP:0001430)5.14576555
8Hyporeflexia of lower limbs (HP:0002600)5.10740940
9Muscle fiber inclusion bodies (HP:0100299)5.09520126
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.98951545
11Type 1 muscle fiber predominance (HP:0003803)4.83840593
12Ventricular tachycardia (HP:0004756)4.75191964
13Myoglobinuria (HP:0002913)4.75176752
14EMG: myopathic abnormalities (HP:0003458)4.60109951
15Increased connective tissue (HP:0009025)4.43901105
16Nemaline bodies (HP:0003798)4.37360018
17Abnormality of the left ventricular outflow tract (HP:0011103)4.35900036
18Subaortic stenosis (HP:0001682)4.35900036
19Atrial fibrillation (HP:0005110)4.30808790
20Myotonia (HP:0002486)4.26364983
21Difficulty running (HP:0009046)4.23155508
22Primary atrial arrhythmia (HP:0001692)4.07372193
23Supraventricular tachycardia (HP:0004755)3.91515946
24Lipoatrophy (HP:0100578)3.88606144
25Supraventricular arrhythmia (HP:0005115)3.84123858
26Distal arthrogryposis (HP:0005684)3.71517635
27Rhabdomyolysis (HP:0003201)3.61519563
28Asymmetric septal hypertrophy (HP:0001670)3.59683314
29Difficulty climbing stairs (HP:0003551)3.54153336
30Muscle stiffness (HP:0003552)3.44725072
31Palpitations (HP:0001962)3.42391925
32Prolonged QT interval (HP:0001657)3.36761957
33Round ear (HP:0100830)3.34576607
34Malignant hyperthermia (HP:0002047)3.34470146
35Right ventricular cardiomyopathy (HP:0011663)3.32432836
36Increased variability in muscle fiber diameter (HP:0003557)3.31517782
37Bundle branch block (HP:0011710)3.31107697
38Abnormality of skeletal muscle fiber size (HP:0012084)3.24768135
39Fetal akinesia sequence (HP:0001989)3.24282287
40Dilated cardiomyopathy (HP:0001644)3.20877060
41Syncope (HP:0001279)3.19507919
42Myopathic facies (HP:0002058)3.13751741
43Ventricular arrhythmia (HP:0004308)3.06975772
44Bulbar palsy (HP:0001283)3.06359267
45Weak cry (HP:0001612)3.00896794
46Distal lower limb muscle weakness (HP:0009053)2.99248139
47Neck muscle weakness (HP:0000467)2.92725680
48Areflexia of lower limbs (HP:0002522)2.81470870
49Popliteal pterygium (HP:0009756)2.70546909
50Mildly elevated creatine phosphokinase (HP:0008180)2.63725655
51Fatigable weakness (HP:0003473)2.63545010
52Abnormality of the neuromuscular junction (HP:0003398)2.63545010
53Heart block (HP:0012722)2.62801737
54Rimmed vacuoles (HP:0003805)2.62221418
55Ulnar deviation of the wrist (HP:0003049)2.61539694
56Abnormal atrioventricular conduction (HP:0005150)2.61162103
57Ventricular fibrillation (HP:0001663)2.57435248
58Abnormal EKG (HP:0003115)2.56114102
59Left ventricular hypertrophy (HP:0001712)2.54022320
60Respiratory insufficiency due to muscle weakness (HP:0002747)2.50904485
61EMG: neuropathic changes (HP:0003445)2.43688100
62Type 2 muscle fiber atrophy (HP:0003554)2.42545570
63Acute necrotizing encephalopathy (HP:0006965)2.40711968
64Abnormal mitochondria in muscle tissue (HP:0008316)2.40444206
65Limb-girdle muscle atrophy (HP:0003797)2.39027497
66Muscular dystrophy (HP:0003560)2.36088194
67Pheochromocytoma (HP:0002666)2.33653588
68Distal lower limb amyotrophy (HP:0008944)2.29955465
69Atrioventricular block (HP:0001678)2.28978014
70Spinal rigidity (HP:0003306)2.27000444
71Generalized muscle weakness (HP:0003324)2.23787862
72Nonprogressive disorder (HP:0003680)2.23739818
73Scapular winging (HP:0003691)2.23533566
74Muscle fiber atrophy (HP:0100295)2.23167238
75Abnormality of the foot musculature (HP:0001436)2.22335790
76Foot dorsiflexor weakness (HP:0009027)2.20024137
77Calcaneovalgus deformity (HP:0001848)2.16142068
78Absent phalangeal crease (HP:0006109)2.13082381
79Gowers sign (HP:0003391)2.11162932
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.09646308
81Neuroendocrine neoplasm (HP:0100634)2.09609680
82Amniotic constriction ring (HP:0009775)2.08069941
83Abnormality of placental membranes (HP:0011409)2.08069941
84Limb-girdle muscle weakness (HP:0003325)2.02833905
85Progressive macrocephaly (HP:0004481)2.01493625
86Exercise intolerance (HP:0003546)2.00583813
87Waddling gait (HP:0002515)1.99923451
88Abnormal ciliary motility (HP:0012262)1.99639528
89Hypoplastic ischia (HP:0003175)1.98202839
90Testicular atrophy (HP:0000029)1.96622870
91Conjunctival hamartoma (HP:0100780)1.93796377
92Deformed tarsal bones (HP:0008119)1.93296627
93Frequent falls (HP:0002359)1.92773132
94Abnormal respiratory motile cilium physiology (HP:0012261)1.91352612
95Hip contracture (HP:0003273)1.91306648
96Easy fatigability (HP:0003388)1.90771075
97Lower limb amyotrophy (HP:0007210)1.89812743
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88402171
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88356333
100Acute encephalopathy (HP:0006846)1.88266031
101Aplasia of the musculature (HP:0100854)1.87177685
102Protrusio acetabuli (HP:0003179)1.87030436
103Hepatic necrosis (HP:0002605)1.85523201
104Abnormality of the ischium (HP:0003174)1.84332351
105Palmoplantar keratoderma (HP:0000982)1.83460280
106Mitochondrial inheritance (HP:0001427)1.82425936
107Abnormality of the musculature of the pelvis (HP:0001469)1.81238912
108Abnormality of the hip-girdle musculature (HP:0001445)1.81238912
109Slender build (HP:0001533)1.79532012
110Ragged-red muscle fibers (HP:0003200)1.79455196
111Abnormality of the shoulder girdle musculature (HP:0001435)1.78447948
112Steppage gait (HP:0003376)1.78253139
113Hepatocellular necrosis (HP:0001404)1.78218002
114Broad metatarsal (HP:0001783)1.77975698
115Facial diplegia (HP:0001349)1.76860957
116Shoulder girdle muscle weakness (HP:0003547)1.76659060
117Proximal amyotrophy (HP:0007126)1.75688998
118Increased CSF lactate (HP:0002490)1.72714545
119Bradycardia (HP:0001662)1.72195071
120Hamartoma of the eye (HP:0010568)1.71473296
121Abnormal finger flexion creases (HP:0006143)1.69777936
122Abnormal respiratory epithelium morphology (HP:0012253)1.68466455
123Abnormal respiratory motile cilium morphology (HP:0005938)1.68466455
124Pelvic girdle muscle weakness (HP:0003749)1.67789550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.65156644
2TTN5.59885071
3PHKG14.60369748
4PHKG24.60369748
5PDK43.29632194
6PDK33.29632194
7NEK12.66292855
8MYLK2.64824330
9LMTK22.35634525
10TRIB32.19745774
11PDK22.08368918
12DMPK2.07176619
13PIK3CA1.99765270
14PINK11.81257571
15MUSK1.79732006
16PKN21.71122358
17STK241.68807663
18NME11.57952327
19PAK31.49272942
20CCNB11.47082000
21MAPKAPK31.46010497
22BCKDK1.41094134
23STK38L1.33293618
24MAPK151.30770104
25LATS21.25535468
26MARK31.24901470
27PIK3CG1.19485227
28PRKD31.16566942
29LIMK11.11803351
30MAPK121.06589934
31ZAK1.05519673
32CAMK2D1.04177869
33ILK1.00797875
34MAP3K71.00343501
35MAP2K41.00249911
36MAP2K30.97935999
37TRPM70.96033230
38RIPK10.95510657
39ROCK10.95024501
40CDC42BPA0.89566609
41DAPK30.85392382
42PRKD10.84763773
43PTK2B0.84323586
44MAP3K40.82111963
45GRK70.81858656
46NME20.78505675
47ARAF0.78391017
48PDGFRA0.77874081
49STK380.77661932
50PAK60.74909608
51ERBB30.74014000
52DDR20.73303087
53TESK10.72437920
54MAP3K10.70890521
55MINK10.69965593
56MAP3K50.69475412
57FER0.66185372
58PRKAA10.64715944
59TIE10.64070297
60CAMK2A0.62002566
61CAMK2G0.61011902
62SGK2230.60741345
63SGK4940.60741345
64PRKG20.60633685
65ROCK20.59197563
66WNK40.58406015
67WNK10.57382164
68ABL20.55406277
69PLK20.54367017
70BMPR1B0.54227743
71GRK50.53145955
72EPHB20.51041433
73ICK0.50016421
74MAP3K30.49665320
75EPHB10.49011283
76STK160.48821564
77PKN10.47488604
78MAPK130.46214860
79DYRK1B0.46159342
80NTRK30.45879963
81PRPF4B0.45216123
82PIM20.44870196
83CAMK40.44853181
84BRAF0.44825813
85LATS10.44571511
86MAP2K10.43592859
87EEF2K0.43419709
88PRKACB0.42709523
89MARK10.42153076
90MAP2K60.41611686
91CSNK1G20.40993402
92PRKAA20.40853249
93SGK20.40462067
94RPS6KA20.40182797
95MAP3K130.39893477
96PRKCE0.39354183
97NTRK10.38664897
98KSR20.37468870
99CAMK10.36960319
100CSNK1G30.36450500
101PRKACA0.36025370
102TAOK10.35881764
103TAOK20.35198274
104MAP3K110.34799046
105SGK30.34414430
106MAPK40.34087958
107CDK50.33131693
108CAMKK20.32299271
109PRKCH0.31045122
110AKT20.30998489
111RPS6KC10.30736177
112RPS6KL10.30736177
113CSNK1A1L0.30550154
114MOS0.29697746
115MARK20.28665994
116CASK0.27693369
117EPHA20.27382392
118MAP3K90.27335486
119PDPK10.26843733
120TGFBR20.26770224
121CAMKK10.26171901
122MAP3K120.26152594
123CDK80.26124854
124CAMK2B0.25361521
125EPHA40.25113272
126MAP2K70.25048757
127KSR10.25012594
128RAF10.24597723
129PRKG10.24291578
130PRKACG0.23054651
131RET0.22746817
132ADRBK10.22715484
133DAPK20.22163131

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.15407604
2Cardiac muscle contraction_Homo sapiens_hsa042604.26024923
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.69469158
4Dilated cardiomyopathy_Homo sapiens_hsa054143.69417151
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.40033891
6Parkinsons disease_Homo sapiens_hsa050122.95124588
7Oxidative phosphorylation_Homo sapiens_hsa001902.90263973
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68185942
9Alzheimers disease_Homo sapiens_hsa050102.27948293
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17729313
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94455803
12Propanoate metabolism_Homo sapiens_hsa006401.94264767
13Carbon metabolism_Homo sapiens_hsa012001.91872965
14Huntingtons disease_Homo sapiens_hsa050161.90410960
15Olfactory transduction_Homo sapiens_hsa047401.86781398
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70656551
17Arginine biosynthesis_Homo sapiens_hsa002201.69281444
18Pyruvate metabolism_Homo sapiens_hsa006201.56647381
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50202774
20Glucagon signaling pathway_Homo sapiens_hsa049221.42403988
21Phenylalanine metabolism_Homo sapiens_hsa003601.42064547
22Oxytocin signaling pathway_Homo sapiens_hsa049211.37601208
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31905523
24Calcium signaling pathway_Homo sapiens_hsa040201.31133209
25Fatty acid degradation_Homo sapiens_hsa000711.30466597
26Insulin signaling pathway_Homo sapiens_hsa049101.19630366
27Viral myocarditis_Homo sapiens_hsa054161.14405582
28Sulfur relay system_Homo sapiens_hsa041221.12720458
29Circadian entrainment_Homo sapiens_hsa047131.12167269
30Pentose phosphate pathway_Homo sapiens_hsa000301.12032044
31Insulin secretion_Homo sapiens_hsa049111.10335632
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08945012
33Fatty acid metabolism_Homo sapiens_hsa012121.05626738
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04422721
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.03935194
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02767017
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01341782
38Tight junction_Homo sapiens_hsa045301.01225624
39Focal adhesion_Homo sapiens_hsa045101.00039044
40Gastric acid secretion_Homo sapiens_hsa049710.99270637
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96344084
42Biosynthesis of amino acids_Homo sapiens_hsa012300.95261527
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92598947
44beta-Alanine metabolism_Homo sapiens_hsa004100.91939579
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91867700
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91765744
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91658965
48Starch and sucrose metabolism_Homo sapiens_hsa005000.89201032
49Nitrogen metabolism_Homo sapiens_hsa009100.86553362
50Galactose metabolism_Homo sapiens_hsa000520.86477538
51Insulin resistance_Homo sapiens_hsa049310.86286397
52Fructose and mannose metabolism_Homo sapiens_hsa000510.84782766
53Synaptic vesicle cycle_Homo sapiens_hsa047210.83031565
54Renin secretion_Homo sapiens_hsa049240.82591219
55GnRH signaling pathway_Homo sapiens_hsa049120.79390855
56Glutathione metabolism_Homo sapiens_hsa004800.79366427
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.78373638
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.77953232
59Long-term potentiation_Homo sapiens_hsa047200.76483135
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75391271
61AMPK signaling pathway_Homo sapiens_hsa041520.75350874
62Cholinergic synapse_Homo sapiens_hsa047250.75325524
63HIF-1 signaling pathway_Homo sapiens_hsa040660.74385496
64Tyrosine metabolism_Homo sapiens_hsa003500.72619387
65Regulation of autophagy_Homo sapiens_hsa041400.72013118
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70969222
67Dopaminergic synapse_Homo sapiens_hsa047280.70745819
68GABAergic synapse_Homo sapiens_hsa047270.70479010
69Gap junction_Homo sapiens_hsa045400.69957192
70PPAR signaling pathway_Homo sapiens_hsa033200.69852942
71Taste transduction_Homo sapiens_hsa047420.69155170
72cAMP signaling pathway_Homo sapiens_hsa040240.68200468
73Peroxisome_Homo sapiens_hsa041460.67764572
74ECM-receptor interaction_Homo sapiens_hsa045120.65325514
75Mineral absorption_Homo sapiens_hsa049780.65227689
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64911710
77Type II diabetes mellitus_Homo sapiens_hsa049300.63260149
78Salivary secretion_Homo sapiens_hsa049700.62673042
79Circadian rhythm_Homo sapiens_hsa047100.61670151
80Morphine addiction_Homo sapiens_hsa050320.61000788
81Amphetamine addiction_Homo sapiens_hsa050310.60957904
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59485545
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55809942
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55171837
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51630584
86Folate biosynthesis_Homo sapiens_hsa007900.51358019
87Collecting duct acid secretion_Homo sapiens_hsa049660.51125096
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50472048
89Glutamatergic synapse_Homo sapiens_hsa047240.50148011
90Vibrio cholerae infection_Homo sapiens_hsa051100.48049319
91Serotonergic synapse_Homo sapiens_hsa047260.47630543
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47277110
93Melanogenesis_Homo sapiens_hsa049160.46639815
94Butanoate metabolism_Homo sapiens_hsa006500.45726189
95Chemical carcinogenesis_Homo sapiens_hsa052040.44278168
96Arginine and proline metabolism_Homo sapiens_hsa003300.43711686
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43357919
98Cocaine addiction_Homo sapiens_hsa050300.43087484
99mTOR signaling pathway_Homo sapiens_hsa041500.43086906
100Fatty acid biosynthesis_Homo sapiens_hsa000610.40031607
101* Metabolic pathways_Homo sapiens_hsa011000.39847757
102Amoebiasis_Homo sapiens_hsa051460.39703721
103Histidine metabolism_Homo sapiens_hsa003400.39448639
104Proteoglycans in cancer_Homo sapiens_hsa052050.39136000
105Adherens junction_Homo sapiens_hsa045200.39103875
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38779111
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38755425
108Estrogen signaling pathway_Homo sapiens_hsa049150.38454382
109VEGF signaling pathway_Homo sapiens_hsa043700.38053346
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38050232
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36944316
112MAPK signaling pathway_Homo sapiens_hsa040100.35046134
113Tryptophan metabolism_Homo sapiens_hsa003800.33843879
114Hedgehog signaling pathway_Homo sapiens_hsa043400.33323876
115Fatty acid elongation_Homo sapiens_hsa000620.31281198
116Glioma_Homo sapiens_hsa052140.31206747
117Long-term depression_Homo sapiens_hsa047300.31189741
118Bile secretion_Homo sapiens_hsa049760.29449898
119Melanoma_Homo sapiens_hsa052180.28854301
120Ovarian steroidogenesis_Homo sapiens_hsa049130.28423068
121Phototransduction_Homo sapiens_hsa047440.28329683
122Axon guidance_Homo sapiens_hsa043600.24562822
123Nicotine addiction_Homo sapiens_hsa050330.24452334
124Oocyte meiosis_Homo sapiens_hsa041140.24199271
125Renal cell carcinoma_Homo sapiens_hsa052110.23959604
126Rap1 signaling pathway_Homo sapiens_hsa040150.23495421
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23224263
128Pancreatic secretion_Homo sapiens_hsa049720.22823772
129FoxO signaling pathway_Homo sapiens_hsa040680.22601687
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22092023

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