AK2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of execution phase of apoptosis (GO:1900118)6.16289737
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66239800
3ATP synthesis coupled proton transport (GO:0015986)4.66239800
4T cell migration (GO:0072678)4.60951796
5mature B cell differentiation involved in immune response (GO:0002313)4.53115935
6S-adenosylmethionine metabolic process (GO:0046500)4.36946190
7protein complex biogenesis (GO:0070271)4.22261821
8regulation of male gonad development (GO:2000018)4.19079817
9water-soluble vitamin biosynthetic process (GO:0042364)4.14317274
10negative T cell selection (GO:0043383)4.10226137
11positive regulation of calcium-mediated signaling (GO:0050850)4.05716502
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.00071364
13positive T cell selection (GO:0043368)3.95626681
14protein polyglutamylation (GO:0018095)3.94949014
15protein neddylation (GO:0045116)3.93190265
16mannosylation (GO:0097502)3.86284543
17positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.83428132
18chaperone-mediated protein transport (GO:0072321)3.77013756
19regulation of mitochondrial translation (GO:0070129)3.74364086
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72645755
21mitochondrial respiratory chain complex assembly (GO:0033108)3.61983904
22pseudouridine synthesis (GO:0001522)3.59403991
23indolalkylamine metabolic process (GO:0006586)3.58896547
24sequestering of actin monomers (GO:0042989)3.57371484
25ribosomal small subunit assembly (GO:0000028)3.46032200
26negative regulation of mast cell activation (GO:0033004)3.45870072
27purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.42067128
28positive thymic T cell selection (GO:0045059)3.36296553
29regulation of cellular extravasation (GO:0002691)3.35578993
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32962003
31mature B cell differentiation (GO:0002335)3.31824841
32viral transcription (GO:0019083)3.29549909
33resolution of meiotic recombination intermediates (GO:0000712)3.27232903
34cotranslational protein targeting to membrane (GO:0006613)3.26205377
35protein targeting to ER (GO:0045047)3.24902374
36adaptation of signaling pathway (GO:0023058)3.24205067
37platelet dense granule organization (GO:0060155)3.23759800
38negative thymic T cell selection (GO:0045060)3.21645204
39negative regulation of membrane potential (GO:0045837)3.20093678
40spliceosomal complex assembly (GO:0000245)3.19587486
41positive regulation of monocyte chemotaxis (GO:0090026)3.18847535
42cytochrome complex assembly (GO:0017004)3.17483913
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16501996
44protein localization to endoplasmic reticulum (GO:0070972)3.15701603
45regulation of T cell receptor signaling pathway (GO:0050856)3.15115826
46negative regulation of interleukin-1 beta production (GO:0032691)3.13010413
47regulation of memory T cell differentiation (GO:0043380)3.12273835
48translational elongation (GO:0006414)3.12231007
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.11371687
50translational termination (GO:0006415)3.11074704
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10940375
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09833918
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.09757726
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06902434
55mitochondrial respiratory chain complex I assembly (GO:0032981)3.03967525
56NADH dehydrogenase complex assembly (GO:0010257)3.03967525
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03967525
58regulation of execution phase of apoptosis (GO:1900117)3.02592474
59primary amino compound metabolic process (GO:1901160)3.01944356
60respiratory electron transport chain (GO:0022904)3.01784065
61positive regulation of protein homodimerization activity (GO:0090073)2.98397777
62lymphocyte chemotaxis (GO:0048247)2.98164453
63regulation of activation of Janus kinase activity (GO:0010533)2.96756934
64monoubiquitinated protein deubiquitination (GO:0035520)2.94891735
65electron transport chain (GO:0022900)2.93862310
66positive regulation of T-helper 1 type immune response (GO:0002827)2.93158561
67inner mitochondrial membrane organization (GO:0007007)2.88836585
68positive regulation of lamellipodium assembly (GO:0010592)2.88475558
69chemokine-mediated signaling pathway (GO:0070098)2.84155354
70cytolysis (GO:0019835)2.84006646
71adenosine metabolic process (GO:0046085)2.82919570
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.81086974
73AMP metabolic process (GO:0046033)2.77042186
74NAD biosynthetic process (GO:0009435)2.75665487
75regulation of B cell receptor signaling pathway (GO:0050855)2.72032858
76positive regulation of endothelial cell differentiation (GO:0045603)2.71651721
77regulation of calcium-mediated signaling (GO:0050848)2.67351294
78establishment of protein localization to mitochondrial membrane (GO:0090151)2.65926703
79negative regulation of interleukin-1 production (GO:0032692)2.65483059
80dendritic cell chemotaxis (GO:0002407)2.64633797
81ribosomal small subunit biogenesis (GO:0042274)2.62807072
82serotonin metabolic process (GO:0042428)2.61706278
83indole-containing compound metabolic process (GO:0042430)2.61043869
84regulation of defense response to virus by virus (GO:0050690)2.60798482
85viral life cycle (GO:0019058)2.60767296
86negative regulation of telomere maintenance (GO:0032205)2.60579292
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59579934
88B cell activation involved in immune response (GO:0002312)2.59487022
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59233319
90G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.58875610
91negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58473538
92protein K48-linked deubiquitination (GO:0071108)2.57451415
93positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.57412297
94regulation of cilium movement (GO:0003352)2.57383054
95ATP biosynthetic process (GO:0006754)2.57347649
96T cell selection (GO:0045058)2.56443726
97purine nucleoside triphosphate biosynthetic process (GO:0009145)2.54414196
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53931498
99regulation of alpha-beta T cell proliferation (GO:0046640)2.53401285
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52437403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.00518709
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.32293818
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.05742553
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75721267
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43901877
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.22996793
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89884080
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.77647846
9FOXP3_21729870_ChIP-Seq_TREG_Human2.70909889
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62569566
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53895008
12VDR_23849224_ChIP-Seq_CD4+_Human2.46990048
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46419632
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39086166
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35100939
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25270422
17GATA3_26560356_Chip-Seq_TH2_Human2.23932382
18CIITA_25753668_ChIP-Seq_RAJI_Human2.18162196
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16122196
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.13565743
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03392329
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98824535
23EWS_26573619_Chip-Seq_HEK293_Human1.94114069
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.93650368
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89649395
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.88477801
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75309262
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73828151
29VDR_22108803_ChIP-Seq_LS180_Human1.69466073
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69227551
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.68635767
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.66269735
33GATA3_27048872_Chip-Seq_THYMUS_Human1.63404769
34TP53_22573176_ChIP-Seq_HFKS_Human1.59139076
35MYB_26560356_Chip-Seq_TH2_Human1.58528584
36ELK1_19687146_ChIP-ChIP_HELA_Human1.53368447
37AR_20517297_ChIP-Seq_VCAP_Human1.53039715
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.52118877
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48915775
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47693170
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45729116
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43044298
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38799233
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38189765
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37037108
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36310028
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35198591
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35069427
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30628262
50RUNX_20019798_ChIP-Seq_JUKART_Human1.28138381
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26393944
52IRF1_19129219_ChIP-ChIP_H3396_Human1.25276618
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24614403
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23550952
55FUS_26573619_Chip-Seq_HEK293_Human1.20197682
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19182293
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19027205
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17597336
59RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16141668
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15434571
61SCL_19346495_ChIP-Seq_HPC-7_Human1.15334440
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.14187765
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.13200481
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13200481
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.13031017
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12663184
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12438670
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11640646
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11355061
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08199248
71HTT_18923047_ChIP-ChIP_STHdh_Human1.07743538
72MYC_19829295_ChIP-Seq_ESCs_Human1.05759911
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05554018
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05077965
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.05001052
76GABP_19822575_ChIP-Seq_HepG2_Human1.04455318
77GATA3_26560356_Chip-Seq_TH1_Human1.04012793
78NCOR_22424771_ChIP-Seq_293T_Human1.03669470
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03522181
80IGF1R_20145208_ChIP-Seq_DFB_Human1.02516129
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02054093
82ERG_20517297_ChIP-Seq_VCAP_Human1.01791928
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98494396
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97114370
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.96669679
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96563172
87MYC_18940864_ChIP-ChIP_HL60_Human0.93895634
88GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93335524
89MYC_18555785_ChIP-Seq_MESCs_Mouse0.93229899
90MYB_26560356_Chip-Seq_TH1_Human0.93213610
91BCL6_27268052_Chip-Seq_Bcells_Human0.92895598
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90050491
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89321707
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88069046
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87700205
96TAF2_19829295_ChIP-Seq_ESCs_Human0.87401317
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87394550
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87055102
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.86722737
100ERA_21632823_ChIP-Seq_H3396_Human0.86561516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.67779919
2MP0003646_muscle_fatigue4.32432007
3MP0005671_abnormal_response_to4.29439707
4MP0002166_altered_tumor_susceptibility4.21814585
5MP0002837_dystrophic_cardiac_calcinosis3.92760313
6MP0003011_delayed_dark_adaptation3.87458577
7MP0002006_tumorigenesis2.91798841
8MP0002736_abnormal_nociception_after2.52585795
9MP0005084_abnormal_gallbladder_morpholo2.20241245
10MP0009785_altered_susceptibility_to2.13537247
11MP0001835_abnormal_antigen_presentation2.12283244
12MP0002933_joint_inflammation2.02575813
13MP0001764_abnormal_homeostasis2.01730843
14MP0004145_abnormal_muscle_electrophysio1.99916339
15MP0006072_abnormal_retinal_apoptosis1.99860043
16MP0001968_abnormal_touch/_nociception1.85153379
17MP0002277_abnormal_respiratory_mucosa1.79489261
18MP0003866_abnormal_defecation1.75998065
19MP0001485_abnormal_pinna_reflex1.58579620
20MP0009764_decreased_sensitivity_to1.56097935
21MP0001542_abnormal_bone_strength1.55940474
22MP0008875_abnormal_xenobiotic_pharmacok1.55512173
23MP0005670_abnormal_white_adipose1.54562546
24MP0005167_abnormal_blood-brain_barrier1.52269018
25MP0009379_abnormal_foot_pigmentation1.52160510
26MP0005000_abnormal_immune_tolerance1.49692175
27MP0002876_abnormal_thyroid_physiology1.49162877
28MP0002148_abnormal_hypersensitivity_rea1.43981316
29MP0005253_abnormal_eye_physiology1.43115571
30MP0009384_cardiac_valve_regurgitation1.38622584
31MP0003806_abnormal_nucleotide_metabolis1.38157132
32MP0000372_irregular_coat_pigmentation1.37995626
33MP0002234_abnormal_pharynx_morphology1.37657598
34MP0005075_abnormal_melanosome_morpholog1.37587182
35MP0003123_paternal_imprinting1.37230094
36MP0003045_fibrosis1.36947645
37MP0008877_abnormal_DNA_methylation1.35766977
38MP0001879_abnormal_lymphatic_vessel1.34848281
39MP0005332_abnormal_amino_acid1.34066900
40MP0006054_spinal_hemorrhage1.28166527
41MP0001905_abnormal_dopamine_level1.27874017
42MP0002138_abnormal_hepatobiliary_system1.25221551
43MP0008775_abnormal_heart_ventricle1.21223379
44MP0003880_abnormal_central_pattern1.19532053
45MP0002420_abnormal_adaptive_immunity1.12875162
46MP0001819_abnormal_immune_cell1.11689429
47MP0001800_abnormal_humoral_immune1.10482199
48MP0003763_abnormal_thymus_physiology1.07887014
49MP0005645_abnormal_hypothalamus_physiol1.07783221
50MP0000685_abnormal_immune_system1.04316328
51MP0002723_abnormal_immune_serum1.03285168
52MP0006082_CNS_inflammation1.02658982
53MP0005025_abnormal_response_to1.01553191
54MP0001963_abnormal_hearing_physiology1.00720841
55MP0003724_increased_susceptibility_to1.00693871
56MP0009643_abnormal_urine_homeostasis1.00589459
57MP0001529_abnormal_vocalization1.00549908
58MP0003787_abnormal_imprinting0.99843624
59MP0003448_altered_tumor_morphology0.99730114
60MP0005379_endocrine/exocrine_gland_phen0.96831760
61MP0000026_abnormal_inner_ear0.94116142
62MP0001727_abnormal_embryo_implantation0.93833384
63MP0002452_abnormal_antigen_presenting0.92871616
64MP0000631_abnormal_neuroendocrine_gland0.92179421
65MP0000343_altered_response_to0.90854701
66MP0010368_abnormal_lymphatic_system0.87606485
67MP0000613_abnormal_salivary_gland0.87511116
68MP0003121_genomic_imprinting0.87381027
69MP0001790_abnormal_immune_system0.86333269
70MP0005387_immune_system_phenotype0.86333269
71MP0005503_abnormal_tendon_morphology0.86181212
72MP0008469_abnormal_protein_level0.85158039
73MP0001324_abnormal_eye_pigmentation0.84954347
74MP0005365_abnormal_bile_salt0.83751226
75MP0004142_abnormal_muscle_tone0.82911036
76MP0005646_abnormal_pituitary_gland0.81314787
77MP0009697_abnormal_copulation0.80956813
78MP0001666_abnormal_nutrient_absorption0.80618869
79MP0004742_abnormal_vestibular_system0.79985665
80MP0003136_yellow_coat_color0.79900397
81MP0002139_abnormal_hepatobiliary_system0.79563166
82MP0005636_abnormal_mineral_homeostasis0.77710432
83MP0003137_abnormal_impulse_conducting0.76244913
84MP0000716_abnormal_immune_system0.75446316
85MP0004133_heterotaxia0.75208393
86MP0008873_increased_physiological_sensi0.73381897
87MP0002019_abnormal_tumor_incidence0.71224979
88MP0001765_abnormal_ion_homeostasis0.70594171
89MP0004883_abnormal_blood_vessel0.70473107
90MP0003567_abnormal_fetal_cardiomyocyte0.70109867
91MP0002693_abnormal_pancreas_physiology0.70015183
92MP0002419_abnormal_innate_immunity0.69281725
93MP0004147_increased_porphyrin_level0.69254665
94MP0010155_abnormal_intestine_physiology0.68997825
95MP0003183_abnormal_peptide_metabolism0.67814973
96MP0002282_abnormal_trachea_morphology0.67684033
97MP0001853_heart_inflammation0.66159430
98MP0009333_abnormal_splenocyte_physiolog0.64491968
99MP0001756_abnormal_urination0.62188213
100MP0002398_abnormal_bone_marrow0.61204165

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.25293736
2Cutaneous melanoma (HP:0012056)4.09816380
3Congenital, generalized hypertrichosis (HP:0004540)4.04872490
4Aplastic anemia (HP:0001915)3.96168917
5True hermaphroditism (HP:0010459)3.90756239
6Mitochondrial inheritance (HP:0001427)3.85705550
7Abnormal mitochondria in muscle tissue (HP:0008316)3.73147044
8Hypoproteinemia (HP:0003075)3.61711576
9Progressive macrocephaly (HP:0004481)3.54450356
10Methylmalonic acidemia (HP:0002912)3.47530021
11Acute encephalopathy (HP:0006846)3.41889326
12Methylmalonic aciduria (HP:0012120)3.41550665
13T lymphocytopenia (HP:0005403)3.27511039
14Increased hepatocellular lipid droplets (HP:0006565)3.20356964
15Gastrointestinal infarctions (HP:0005244)3.17097217
16Thyroid-stimulating hormone excess (HP:0002925)3.14685813
17Increased CSF lactate (HP:0002490)3.06768628
18Abnormality of T cell number (HP:0011839)3.06412731
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98005909
20Cerebral edema (HP:0002181)2.91803001
21Congenital stationary night blindness (HP:0007642)2.90466839
22Renal Fanconi syndrome (HP:0001994)2.89787913
23Severe combined immunodeficiency (HP:0004430)2.88074185
24Panhypogammaglobulinemia (HP:0003139)2.83152918
25Abnormality of the phalanges of the 2nd finger (HP:0009541)2.80212150
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.80142239
27Woolly hair (HP:0002224)2.79894479
28Pancreatic cysts (HP:0001737)2.78834798
29Abnormality of B cell number (HP:0010975)2.69035491
30Lipid accumulation in hepatocytes (HP:0006561)2.67939801
31B lymphocytopenia (HP:0010976)2.67703003
323-Methylglutaconic aciduria (HP:0003535)2.65363575
33Hepatocellular necrosis (HP:0001404)2.62964940
34Exertional dyspnea (HP:0002875)2.59085394
35IgG deficiency (HP:0004315)2.55129767
36Short tibia (HP:0005736)2.49826609
37Hyperglycinemia (HP:0002154)2.47723219
38Hepatic necrosis (HP:0002605)2.45848295
39Sex reversal (HP:0012245)2.45253311
40Abnormal sex determination (HP:0012244)2.45253311
41Abnormality of methionine metabolism (HP:0010901)2.44414815
42Abnormality of T cells (HP:0002843)2.44279687
43Chronic diarrhea (HP:0002028)2.44013005
44Aplasia/hypoplasia of the uterus (HP:0008684)2.42462641
45Spinal muscular atrophy (HP:0007269)2.41567542
46Combined immunodeficiency (HP:0005387)2.40940925
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40752965
48Irregular vertebral endplates (HP:0003301)2.40592642
49Acute hepatic failure (HP:0006554)2.38089315
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.36939892
51Hypothermia (HP:0002045)2.34985754
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34756404
53Dicarboxylic aciduria (HP:0003215)2.34756404
54Abnormality of vitamin B metabolism (HP:0004340)2.30688158
55Male pseudohermaphroditism (HP:0000037)2.26374538
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.25154661
57Progressive neurologic deterioration (HP:0002344)2.20867200
58Bile duct proliferation (HP:0001408)2.19428667
59Abnormal biliary tract physiology (HP:0012439)2.19428667
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.19279218
61Pancreatic fibrosis (HP:0100732)2.19270681
62Pancytopenia (HP:0001876)2.15327723
63Increased intramyocellular lipid droplets (HP:0012240)2.14373362
64Carpal bone hypoplasia (HP:0001498)2.13226117
65Mesangial abnormality (HP:0001966)2.12976517
66Elevated erythrocyte sedimentation rate (HP:0003565)2.12905166
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08351241
68Nephronophthisis (HP:0000090)2.07036619
69Cystic liver disease (HP:0006706)2.06197994
70Hypoalbuminemia (HP:0003073)2.05756322
71Abnormal albumin level (HP:0012116)2.05756322
72Respiratory failure (HP:0002878)2.04215728
73Neoplasm of the lung (HP:0100526)2.00685709
74Lactic acidosis (HP:0003128)1.97234049
75J-shaped sella turcica (HP:0002680)1.95132039
76Stomatitis (HP:0010280)1.94671408
77Occipital encephalocele (HP:0002085)1.94289353
78Stenosis of the external auditory canal (HP:0000402)1.93393569
79Abnormality of the parietal bone (HP:0002696)1.90278485
80Agammaglobulinemia (HP:0004432)1.89268563
81Abnormality of the 2nd finger (HP:0004100)1.89182045
82Abnormality of the middle phalanges of the toes (HP:0010183)1.87193588
83Abnormality of the prostate (HP:0008775)1.86681989
84Intestinal atresia (HP:0011100)1.86420571
85Increased CSF protein (HP:0002922)1.85434066
86Radial bowing (HP:0002986)1.84934752
87Deformed sella turcica (HP:0002681)1.84827754
88Type I transferrin isoform profile (HP:0003642)1.84650685
89Hypoplasia of the odontoid process (HP:0003311)1.83920408
90Neurodegeneration (HP:0002180)1.81779632
91Neoplasm of the respiratory system (HP:0100606)1.81697229
92Abnormality of the vertebral endplates (HP:0005106)1.81528712
93Molar tooth sign on MRI (HP:0002419)1.80203672
94Abnormality of midbrain morphology (HP:0002418)1.80203672
95Meningioma (HP:0002858)1.78268753
96Hypomagnesemia (HP:0002917)1.76624520
97Lethargy (HP:0001254)1.76541743
98Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75918374
99Optic disc pallor (HP:0000543)1.75748067
100Abnormality of the axillary hair (HP:0100134)1.74488964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF14.16065559
2TIE13.75331617
3KDR3.44383812
4VRK23.41862391
5STK392.83862394
6WNK42.35867184
7GRK12.32071332
8BRSK22.19319717
9GRK72.17894281
10TEC1.92797424
11WEE11.80545214
12VRK11.78123589
13ZAK1.78014707
14TGFBR21.75000948
15MAP3K121.73272537
16FRK1.72117008
17MST41.71834304
18MAP3K131.71173503
19MOS1.60266478
20OXSR11.60237258
21CDK191.58458179
22INSRR1.45869721
23PHKG11.41885635
24PHKG21.41885635
25ADRBK21.39339417
26TESK21.36904367
27SCYL21.35512849
28TNIK1.28866680
29ITK1.23868030
30FES1.23016621
31EIF2AK31.21763876
32MAP4K11.21385919
33FLT31.18930434
34NUAK11.18704039
35MAPK131.18482075
36GRK51.14668832
37ERBB31.11153301
38KIT1.10265275
39UHMK11.06218005
40CCNB11.04477827
41BTK1.04447500
42MKNK11.04255145
43STK161.04134447
44PLK41.02469860
45CSF1R1.01462887
46MARK30.98860135
47MYLK0.98375393
48SRPK10.97076231
49TXK0.96578773
50NEK10.92392078
51ACVR1B0.90139562
52BRSK10.87943993
53PDK20.86244389
54TLK10.85184601
55MAP3K110.79482987
56MAPKAPK50.76494974
57LIMK10.75772474
58PLK30.74473003
59SIK30.74295880
60PRKCQ0.71551849
61NEK90.65216225
62PRKCE0.63647421
63CSNK1G30.63133707
64WNK30.63027316
65GRK60.62776522
66STK38L0.62183892
67TAOK30.62095625
68SYK0.62058099
69STK100.61376073
70PASK0.60246598
71MAP2K20.59650823
72STK30.58803664
73EIF2AK20.57141862
74LYN0.57006310
75ILK0.56302143
76IRAK10.55780699
77TAOK20.54720596
78BCKDK0.52480129
79TESK10.50737491
80TNK20.50628344
81ERBB20.49602124
82HCK0.48073469
83IGF1R0.47762054
84MAP4K20.47279449
85TGFBR10.45369307
86BRAF0.44441668
87IKBKB0.44353475
88LRRK20.44270138
89PLK10.43796818
90NME10.43063436
91AURKB0.42970230
92PKN20.41037986
93ADRBK10.40984353
94BCR0.40649698
95CLK10.40233830
96LCK0.39007505
97PIM10.38247538
98IRAK40.38209757
99ARAF0.36923266
100PRKAA20.34875989

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.35002400
2Sulfur relay system_Homo sapiens_hsa041223.78645729
3Sulfur metabolism_Homo sapiens_hsa009203.32923692
4Oxidative phosphorylation_Homo sapiens_hsa001903.31315341
5Ribosome_Homo sapiens_hsa030103.08682254
6Protein export_Homo sapiens_hsa030602.92999427
7Proteasome_Homo sapiens_hsa030502.72912395
8Parkinsons disease_Homo sapiens_hsa050122.67274688
9Folate biosynthesis_Homo sapiens_hsa007902.37676130
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.17233157
11Antigen processing and presentation_Homo sapiens_hsa046122.17177306
12Graft-versus-host disease_Homo sapiens_hsa053321.94747300
13RNA degradation_Homo sapiens_hsa030181.88502037
14Allograft rejection_Homo sapiens_hsa053301.88028508
15Alzheimers disease_Homo sapiens_hsa050101.87576981
16Asthma_Homo sapiens_hsa053101.82317967
17Autoimmune thyroid disease_Homo sapiens_hsa053201.77217801
18Caffeine metabolism_Homo sapiens_hsa002321.76675956
19Hematopoietic cell lineage_Homo sapiens_hsa046401.75773959
20One carbon pool by folate_Homo sapiens_hsa006701.75203997
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.65560933
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64241955
23Type I diabetes mellitus_Homo sapiens_hsa049401.62097584
24Basal transcription factors_Homo sapiens_hsa030221.53658109
25Homologous recombination_Homo sapiens_hsa034401.52493404
26Huntingtons disease_Homo sapiens_hsa050161.49490554
27Spliceosome_Homo sapiens_hsa030401.42661791
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39493993
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31112078
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28755216
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26030972
32Chemical carcinogenesis_Homo sapiens_hsa052041.25700599
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20704842
34Nucleotide excision repair_Homo sapiens_hsa034201.17009655
35Tryptophan metabolism_Homo sapiens_hsa003801.12705601
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10127906
37Rheumatoid arthritis_Homo sapiens_hsa053231.05777309
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04939626
39Peroxisome_Homo sapiens_hsa041461.04904749
40T cell receptor signaling pathway_Homo sapiens_hsa046600.99915402
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.99557348
42Retinol metabolism_Homo sapiens_hsa008300.97637784
43Regulation of autophagy_Homo sapiens_hsa041400.96158935
44Linoleic acid metabolism_Homo sapiens_hsa005910.95801089
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95207158
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94052363
47Phototransduction_Homo sapiens_hsa047440.91772845
48Cardiac muscle contraction_Homo sapiens_hsa042600.91475962
49RNA polymerase_Homo sapiens_hsa030200.86361491
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.84627819
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.82232948
52Base excision repair_Homo sapiens_hsa034100.81673494
53Butanoate metabolism_Homo sapiens_hsa006500.80536720
54Shigellosis_Homo sapiens_hsa051310.79339886
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78886173
56p53 signaling pathway_Homo sapiens_hsa041150.77942689
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77428276
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75708627
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74569574
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73954248
61Malaria_Homo sapiens_hsa051440.73639577
62Tyrosine metabolism_Homo sapiens_hsa003500.67092420
63beta-Alanine metabolism_Homo sapiens_hsa004100.66465974
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64778931
65Purine metabolism_Homo sapiens_hsa002300.63872328
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62100745
67Propanoate metabolism_Homo sapiens_hsa006400.60739542
68Viral myocarditis_Homo sapiens_hsa054160.58589632
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57826139
70Non-homologous end-joining_Homo sapiens_hsa034500.57604948
71Olfactory transduction_Homo sapiens_hsa047400.57230058
72Staphylococcus aureus infection_Homo sapiens_hsa051500.54806551
73Pyrimidine metabolism_Homo sapiens_hsa002400.54372899
74Vitamin digestion and absorption_Homo sapiens_hsa049770.52685923
75Glutathione metabolism_Homo sapiens_hsa004800.52336957
76Metabolic pathways_Homo sapiens_hsa011000.48390907
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46762596
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46600294
79Measles_Homo sapiens_hsa051620.46529631
80Arachidonic acid metabolism_Homo sapiens_hsa005900.44581114
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44237701
82Collecting duct acid secretion_Homo sapiens_hsa049660.44052473
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42704346
84Fat digestion and absorption_Homo sapiens_hsa049750.42267605
85N-Glycan biosynthesis_Homo sapiens_hsa005100.40496571
86Systemic lupus erythematosus_Homo sapiens_hsa053220.40491242
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38051371
88Phenylalanine metabolism_Homo sapiens_hsa003600.35510326
89Nitrogen metabolism_Homo sapiens_hsa009100.34513909
90Pertussis_Homo sapiens_hsa051330.31716012
91RNA transport_Homo sapiens_hsa030130.27680494
92Herpes simplex infection_Homo sapiens_hsa051680.26276239
93Leishmaniasis_Homo sapiens_hsa051400.24695459
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.23933593
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.22078436
96Ether lipid metabolism_Homo sapiens_hsa005650.18316779
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18260264
98Phagosome_Homo sapiens_hsa041450.17408726
99Fanconi anemia pathway_Homo sapiens_hsa034600.15398363
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12733656

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