AK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.75727141
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75727141
3L-phenylalanine metabolic process (GO:0006558)6.49985502
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.49985502
5aromatic amino acid family catabolic process (GO:0009074)5.90816371
6alpha-linolenic acid metabolic process (GO:0036109)5.69520118
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52236078
8cysteine metabolic process (GO:0006534)5.41024282
9glyoxylate metabolic process (GO:0046487)5.35829399
10actin-myosin filament sliding (GO:0033275)5.34455360
11muscle filament sliding (GO:0030049)5.34455360
12lysine metabolic process (GO:0006553)5.21150425
13lysine catabolic process (GO:0006554)5.21150425
14bile acid biosynthetic process (GO:0006699)5.19761796
15indole-containing compound catabolic process (GO:0042436)5.18836870
16indolalkylamine catabolic process (GO:0046218)5.18836870
17tryptophan catabolic process (GO:0006569)5.18836870
18sulfur amino acid catabolic process (GO:0000098)5.17630601
19kynurenine metabolic process (GO:0070189)5.17366817
20tryptophan metabolic process (GO:0006568)4.93148150
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90134542
22urea metabolic process (GO:0019627)4.82917877
23urea cycle (GO:0000050)4.82917877
24actin-mediated cell contraction (GO:0070252)4.72448616
25complement activation, alternative pathway (GO:0006957)4.66651403
26homocysteine metabolic process (GO:0050667)4.64296034
27negative regulation of fibrinolysis (GO:0051918)4.61686972
28regulation of triglyceride catabolic process (GO:0010896)4.59963737
29high-density lipoprotein particle remodeling (GO:0034375)4.57640822
30amino-acid betaine metabolic process (GO:0006577)4.53158286
31regulation of protein activation cascade (GO:2000257)4.50911892
32peptidyl-glutamic acid carboxylation (GO:0017187)4.49355156
33protein carboxylation (GO:0018214)4.49355156
34bile acid metabolic process (GO:0008206)4.44501428
35serine family amino acid catabolic process (GO:0009071)4.44129016
36nitrogen cycle metabolic process (GO:0071941)4.43764324
37sarcoplasmic reticulum calcium ion transport (GO:0070296)4.43565959
38regulation of fibrinolysis (GO:0051917)4.33466052
39ethanol oxidation (GO:0006069)4.31856127
40aromatic amino acid family metabolic process (GO:0009072)4.28496280
41alpha-amino acid catabolic process (GO:1901606)4.27039464
42regulation of complement activation (GO:0030449)4.26380621
43NADH metabolic process (GO:0006734)4.25625012
44cellular ketone body metabolic process (GO:0046950)4.21960132
45creatine metabolic process (GO:0006600)4.20523009
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.20248465
47tyrosine metabolic process (GO:0006570)4.16934432
48acylglycerol homeostasis (GO:0055090)4.13328004
49triglyceride homeostasis (GO:0070328)4.13328004
50reverse cholesterol transport (GO:0043691)4.11947519
51short-chain fatty acid metabolic process (GO:0046459)4.10580198
52regulation of skeletal muscle contraction (GO:0014819)4.09422536
53cellular amino acid catabolic process (GO:0009063)4.06034590
54cellular modified amino acid catabolic process (GO:0042219)4.05393158
55glutamate metabolic process (GO:0006536)4.04957379
56myofibril assembly (GO:0030239)4.04254010
57blood coagulation, intrinsic pathway (GO:0007597)4.02621164
58plasma lipoprotein particle remodeling (GO:0034369)4.01786996
59protein-lipid complex remodeling (GO:0034368)4.01786996
60macromolecular complex remodeling (GO:0034367)4.01786996
61negative regulation of cholesterol transport (GO:0032375)4.01736987
62negative regulation of sterol transport (GO:0032372)4.01736987
63acetyl-CoA metabolic process (GO:0006084)4.01182629
64fatty acid beta-oxidation (GO:0006635)3.98916929
65regulation of cholesterol esterification (GO:0010872)3.97538584
66plasma lipoprotein particle clearance (GO:0034381)3.97142984
67aspartate family amino acid catabolic process (GO:0009068)3.94182005
68coenzyme catabolic process (GO:0009109)3.92825800
69carnitine shuttle (GO:0006853)3.92409891
70valine metabolic process (GO:0006573)3.91516397
712-oxoglutarate metabolic process (GO:0006103)3.88391957
72fatty acid oxidation (GO:0019395)3.88124919
73exogenous drug catabolic process (GO:0042738)3.85482001
74cellular glucuronidation (GO:0052695)3.84753705
75regulation of relaxation of muscle (GO:1901077)3.84677717
76serine family amino acid metabolic process (GO:0009069)3.82533890
77fatty acid transmembrane transport (GO:1902001)3.82501714
78lipid oxidation (GO:0034440)3.81327153
79response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.79683259
80phospholipid efflux (GO:0033700)3.79572129
81dicarboxylic acid biosynthetic process (GO:0043650)3.78909564
82regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.78584095
83drug catabolic process (GO:0042737)3.76522952
84cardiac myofibril assembly (GO:0055003)3.76231196
85fatty acid catabolic process (GO:0009062)3.74547079
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.74098464
87bile acid and bile salt transport (GO:0015721)3.72347592
88positive regulation of lipid catabolic process (GO:0050996)3.71015389
89organic acid catabolic process (GO:0016054)3.70277223
90carboxylic acid catabolic process (GO:0046395)3.70277223
91monocarboxylic acid catabolic process (GO:0072329)3.69799769
92ketone body metabolic process (GO:1902224)3.69124783
93benzene-containing compound metabolic process (GO:0042537)3.67305750
94serine family amino acid biosynthetic process (GO:0009070)3.64760409
95indolalkylamine metabolic process (GO:0006586)3.64363428
96glycine metabolic process (GO:0006544)3.63303235
97sarcomere organization (GO:0045214)3.62469818
98regulation of cholesterol homeostasis (GO:2000188)3.61524736
99carnitine metabolic process (GO:0009437)3.61315555
100skeletal muscle contraction (GO:0003009)3.58531387
101drug transmembrane transport (GO:0006855)3.57897541
102phospholipid homeostasis (GO:0055091)3.52317367
103cholesterol efflux (GO:0033344)3.50603014
104amine catabolic process (GO:0009310)3.49273920
105cellular biogenic amine catabolic process (GO:0042402)3.49273920
106plasma lipoprotein particle assembly (GO:0034377)3.46539166
107flavonoid metabolic process (GO:0009812)3.45026385
108actin filament-based movement (GO:0030048)3.43692051
109cholesterol homeostasis (GO:0042632)3.41769337
110regulation of cholesterol metabolic process (GO:0090181)3.40587343
111glucuronate metabolic process (GO:0019585)3.39831266
112uronic acid metabolic process (GO:0006063)3.39831266
113positive regulation of triglyceride lipase activity (GO:0061365)3.39710342
114positive regulation of lipoprotein lipase activity (GO:0051006)3.39710342
115branched-chain amino acid catabolic process (GO:0009083)3.38960926
116negative regulation of lipase activity (GO:0060192)3.38493861
117epoxygenase P450 pathway (GO:0019373)3.37920054
118sterol homeostasis (GO:0055092)3.37686844
119response to muscle activity (GO:0014850)3.34621781
120arginine metabolic process (GO:0006525)3.33490503
121ethanol metabolic process (GO:0006067)3.32300886
122regulation of lipoprotein metabolic process (GO:0050746)3.31133358
123glycogen catabolic process (GO:0005980)3.23831733
124striated muscle contraction (GO:0006941)3.23756344
125oxaloacetate metabolic process (GO:0006107)3.20838751
126very-low-density lipoprotein particle assembly (GO:0034379)3.20670938
127carnitine transport (GO:0015879)3.19122750
128amino-acid betaine transport (GO:0015838)3.19122750
129carnitine transmembrane transport (GO:1902603)3.17014639
130regulation of cell communication by electrical coupling (GO:0010649)3.12627107
131negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.10563960
132cellular polysaccharide catabolic process (GO:0044247)3.07367146
133glucan catabolic process (GO:0009251)3.03581953
134regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.02211941
135low-density lipoprotein particle remodeling (GO:0034374)3.00033353
136regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.99284778
137intestinal cholesterol absorption (GO:0030299)2.97772307
138regulation of sequestering of triglyceride (GO:0010889)2.95484006
139actomyosin structure organization (GO:0031032)2.94700735
140intestinal absorption (GO:0050892)2.93882717
141negative regulation of potassium ion transmembrane transport (GO:1901380)2.90822805
142daunorubicin metabolic process (GO:0044597)2.89748401
143polyketide metabolic process (GO:0030638)2.89748401
144doxorubicin metabolic process (GO:0044598)2.89748401
145cardiac muscle contraction (GO:0060048)2.89627169
146tricarboxylic acid cycle (GO:0006099)2.88679268
147regulation of actin filament-based movement (GO:1903115)2.82877330
148regulation of plasminogen activation (GO:0010755)2.81919139
149response to mercury ion (GO:0046689)2.77896141
150quaternary ammonium group transport (GO:0015697)2.77097952
151negative regulation of protein localization to cell surface (GO:2000009)2.76957599
152muscle contraction (GO:0006936)2.76180955
153fatty acid homeostasis (GO:0055089)2.74955938
154negative regulation of protein activation cascade (GO:2000258)2.74881015
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74059846
156aminoglycoside antibiotic metabolic process (GO:0030647)2.72344176
157polysaccharide catabolic process (GO:0000272)2.71801443
158triglyceride catabolic process (GO:0019433)2.70509223
159fibrinolysis (GO:0042730)2.64565152
160fructose metabolic process (GO:0006000)2.62246287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.38297441
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40878699
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.26612404
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.85325004
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.38451457
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52024764
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.95272571
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72353249
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.98130484
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82061955
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45970314
12* CLOCK_20551151_ChIP-Seq_293T_Human2.31043994
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03605173
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01472776
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4823143
16* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95798940
17IGF1R_20145208_ChIP-Seq_DFB_Human1.86376478
18GBX2_23144817_ChIP-Seq_PC3_Human1.75843420
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.73106376
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71798212
21GATA1_22025678_ChIP-Seq_K562_Human1.69371286
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68943415
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.67463818
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67289105
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.56708455
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52334293
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48394513
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45836440
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45733881
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43713355
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.40435619
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35526648
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35469267
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35047999
35* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34502072
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33247564
37FUS_26573619_Chip-Seq_HEK293_Human1.29980506
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29737554
39VDR_22108803_ChIP-Seq_LS180_Human1.26896444
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26504456
41ZNF263_19887448_ChIP-Seq_K562_Human1.26378765
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26363883
43TP53_16413492_ChIP-PET_HCT116_Human1.25415498
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.24956510
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24022103
46MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.21950650
47GATA4_25053715_ChIP-Seq_YYC3_Human1.21755670
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20089058
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.18104184
50CJUN_26792858_Chip-Seq_BT549_Human1.17470572
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16690349
52* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13770047
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.13621709
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.12792924
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12102365
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.12034674
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11079965
58TAF15_26573619_Chip-Seq_HEK293_Human1.10267481
59CDX2_22108803_ChIP-Seq_LS180_Human1.10225156
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10207875
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09809326
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08847355
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.06046354
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04907784
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04794436
66HTT_18923047_ChIP-ChIP_STHdh_Human1.04538447
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04244008
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03988160
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03944877
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03694452
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01609285
72* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01363311
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00433757
74PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99754769
75STAT3_23295773_ChIP-Seq_U87_Human0.99056201
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98569102
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98525419
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98409906
79CDX2_20551321_ChIP-Seq_CACO-2_Human0.98214280
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.98037325
81FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97460029
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96490325
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.96379736
84P53_22387025_ChIP-Seq_ESCs_Mouse0.96116946
85* TCF4_23295773_ChIP-Seq_U87_Human0.95766298
86TAL1_26923725_Chip-Seq_HPCs_Mouse0.94849080
87ER_23166858_ChIP-Seq_MCF-7_Human0.94765353
88GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94555929
89EZH2_22144423_ChIP-Seq_EOC_Human0.94283544
90TRIM28_21343339_ChIP-Seq_HEK293_Human0.91834699
91TP53_18474530_ChIP-ChIP_U2OS_Human0.91618201
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91587263
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91306807
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90702094
95NANOG_19829295_ChIP-Seq_ESCs_Human0.89210268
96SOX2_19829295_ChIP-Seq_ESCs_Human0.89210268
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89177357
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89177357
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88719350
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88363651
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88055350
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87880666
103SOX2_21211035_ChIP-Seq_LN229_Gbm0.87632491
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87275657
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.87217809
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86184368
107LXR_22292898_ChIP-Seq_THP-1_Human0.85979312
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85321069
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.82608322
110SOX2_20726797_ChIP-Seq_SW620_Human0.81117552
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80782300
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80720258
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80372093
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.79687044
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.79687044
116GATA6_25053715_ChIP-Seq_YYC3_Human0.78705812
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76932070
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76922662
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76688549
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74457183
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73387475
122GATA1_19941826_ChIP-Seq_K562_Human0.73105507
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.72777822
124EGR1_19032775_ChIP-ChIP_M12_Human0.72242771
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.72067131
126RACK7_27058665_Chip-Seq_MCF-7_Human0.70561274
127GATA2_19941826_ChIP-Seq_K562_Human0.69997358
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69513185
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.69284527
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67875684
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.67673588
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65593842
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65216594
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64441300
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.64380220
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.63969567
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62448427
138CEBPB_22108803_ChIP-Seq_LS180_Human0.61759369
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61079663
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.60982833
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60669522
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58528221
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.57809351
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.56835266
145CBP_21632823_ChIP-Seq_H3396_Human0.55756922
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.53017748
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.52558843
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.52208534
149P63_26484246_Chip-Seq_KERATINOCYTES_Human0.52204272
150* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52009295
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.51596320
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49814128
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.49695802
154FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49339324
155AR_20517297_ChIP-Seq_VCAP_Human0.48797177
156BCAT_22108803_ChIP-Seq_LS180_Human0.48439056
157MYC_19915707_ChIP-ChIP_AK7_Human0.48031223
158KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.47431099
159P53_21459846_ChIP-Seq_SAOS-2_Human0.46931253
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.46555782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.51824919
2MP0005360_urolithiasis7.03018713
3MP0005085_abnormal_gallbladder_physiolo5.79918444
4MP0005365_abnormal_bile_salt5.70196654
5MP0008875_abnormal_xenobiotic_pharmacok4.58164759
6MP0004145_abnormal_muscle_electrophysio3.91642059
7MP0003252_abnormal_bile_duct3.78184920
8MP0003806_abnormal_nucleotide_metabolis3.75210169
9MP0000751_myopathy3.70493817
10MP0003646_muscle_fatigue3.50596571
11MP0010329_abnormal_lipoprotein_level3.47405667
12MP0004084_abnormal_cardiac_muscle3.21142443
13MP0004036_abnormal_muscle_relaxation3.09392241
14MP0005083_abnormal_biliary_tract3.06233091
15MP0001666_abnormal_nutrient_absorption2.97281426
16MP0005332_abnormal_amino_acid2.91042603
17MP0000749_muscle_degeneration2.74381316
18MP0009840_abnormal_foam_cell2.73714411
19MP0003195_calcinosis2.58245302
20MP0004215_abnormal_myocardial_fiber2.56927444
21MP0000013_abnormal_adipose_tissue2.26532444
22MP0003191_abnormal_cellular_cholesterol2.25850681
23MP0002106_abnormal_muscle_physiology2.22880035
24MP0002118_abnormal_lipid_homeostasis2.20711271
25MP0004087_abnormal_muscle_fiber2.19723381
26MP0004019_abnormal_vitamin_homeostasis2.15458465
27MP0000609_abnormal_liver_physiology2.06977879
28MP0005620_abnormal_muscle_contractility2.01260785
29MP0005369_muscle_phenotype1.90005259
30MP0002138_abnormal_hepatobiliary_system1.87045093
31MP0002269_muscular_atrophy1.85265807
32MP0008775_abnormal_heart_ventricle1.84896973
33MP0000747_muscle_weakness1.84313707
34MP0006138_congestive_heart_failure1.83107965
35MP0005319_abnormal_enzyme/_coenzyme1.81888635
36MP0000759_abnormal_skeletal_muscle1.78300354
37MP0009780_abnormal_chondrocyte_physiolo1.78272055
38MP0002972_abnormal_cardiac_muscle1.76443765
39MP0003868_abnormal_feces_composition1.74558011
40MP0005584_abnormal_enzyme/coenzyme_acti1.72212907
41MP0003705_abnormal_hypodermis_morpholog1.59936214
42MP0009643_abnormal_urine_homeostasis1.56591113
43MP0004484_altered_response_of1.54268800
44MP0001544_abnormal_cardiovascular_syste1.52880205
45MP0005385_cardiovascular_system_phenoty1.52880205
46MP0004130_abnormal_muscle_cell1.48812783
47MP0005670_abnormal_white_adipose1.43506281
48MP0003186_abnormal_redox_activity1.37484021
49MP0001764_abnormal_homeostasis1.34751842
50MP0003656_abnormal_erythrocyte_physiolo1.24560503
51MP0010630_abnormal_cardiac_muscle1.24138867
52MP0002332_abnormal_exercise_endurance1.22396711
53MP0002127_abnormal_cardiovascular_syste1.22132610
54MP0000750_abnormal_muscle_regeneration1.19838656
55MP0005666_abnormal_adipose_tissue1.18131043
56MP0003011_delayed_dark_adaptation1.18081839
57MP0004085_abnormal_heartbeat1.17285777
58MP0002108_abnormal_muscle_morphology1.14224347
59MP0005451_abnormal_body_composition1.13724817
60MP0005636_abnormal_mineral_homeostasis1.09816566
61MP0000598_abnormal_liver_morphology1.09227226
62MP0000604_amyloidosis1.04981521
63MP0002971_abnormal_brown_adipose1.04251045
64MP0010234_abnormal_vibrissa_follicle1.03869359
65MP0004272_abnormal_basement_membrane1.03527680
66MP0000003_abnormal_adipose_tissue1.02888010
67MP0006036_abnormal_mitochondrial_physio1.01415120
68MP0005084_abnormal_gallbladder_morpholo1.00578029
69MP0004233_abnormal_muscle_weight0.99227192
70MP0003941_abnormal_skin_development0.95557935
71MP0003122_maternal_imprinting0.94451928
72MP0005220_abnormal_exocrine_pancreas0.94388440
73MP0001756_abnormal_urination0.94313196
74MP0009697_abnormal_copulation0.92862129
75MP0005647_abnormal_sex_gland0.92319330
76MP0009764_decreased_sensitivity_to0.91055906
77MP0003690_abnormal_glial_cell0.90389817
78MP0003137_abnormal_impulse_conducting0.89590762
79MP0003950_abnormal_plasma_membrane0.89321479
80MP0002078_abnormal_glucose_homeostasis0.89070896
81MP0002254_reproductive_system_inflammat0.89000366
82MP0004043_abnormal_pH_regulation0.87588427
83MP0009763_increased_sensitivity_to0.87256750
84MP0005334_abnormal_fat_pad0.85085836
85MP0009642_abnormal_blood_homeostasis0.84959711
86MP0010368_abnormal_lymphatic_system0.84533114
87MP0005408_hypopigmentation0.84281765
88MP0005535_abnormal_body_temperature0.83573985
89MP0005409_darkened_coat_color0.83562889
90MP0002837_dystrophic_cardiac_calcinosis0.82990666
91MP0001661_extended_life_span0.77738224
92MP0008469_abnormal_protein_level0.77343657
93MP0003329_amyloid_beta_deposits0.77082218
94MP0004185_abnormal_adipocyte_glucose0.77020394
95MP0003300_gastrointestinal_ulcer0.76044394
96MP0002909_abnormal_adrenal_gland0.72422964
97MP0009384_cardiac_valve_regurgitation0.72201715
98MP0002136_abnormal_kidney_physiology0.70466615
99MP0002796_impaired_skin_barrier0.69746938
100MP0005448_abnormal_energy_balance0.69147830
101MP0002876_abnormal_thyroid_physiology0.68295053
102MP0005375_adipose_tissue_phenotype0.68258548
103MP0001879_abnormal_lymphatic_vessel0.67561988
104MP0004134_abnormal_chest_morphology0.67212556
105MP0005376_homeostasis/metabolism_phenot0.67163931
106MP0002128_abnormal_blood_circulation0.65740381
107MP0001299_abnormal_eye_distance/0.64169767
108MP0002638_abnormal_pupillary_reflex0.63687748
109MP0009765_abnormal_xenobiotic_induced0.62524325
110MP0005167_abnormal_blood-brain_barrier0.62184727
111MP0000733_abnormal_muscle_development0.61314614
112MP0008438_abnormal_cutaneous_collagen0.59896476
113MP0004270_analgesia0.59205223
114MP0000266_abnormal_heart_morphology0.57535566
115MP0005165_increased_susceptibility_to0.57514046
116MP0000566_synostosis0.56454490
117MP0005058_abnormal_lysosome_morphology0.55963343
118MP0005266_abnormal_metabolism0.55758159
119MP0009115_abnormal_fat_cell0.55488162
120MP0001765_abnormal_ion_homeostasis0.54341537
121MP0005187_abnormal_penis_morphology0.54317037
122MP0003638_abnormal_response/metabolism_0.53757406
123MP0003075_altered_response_to0.51646632
124MP0000230_abnormal_systemic_arterial0.51191993
125MP0009053_abnormal_anal_canal0.49824365
126MP0002970_abnormal_white_adipose0.49357893
127MP0002928_abnormal_bile_duct0.48918731
128MP0003953_abnormal_hormone_level0.48670019
129MP0006035_abnormal_mitochondrial_morpho0.48521989
130MP0002060_abnormal_skin_morphology0.47782227
131MP0005275_abnormal_skin_tensile0.46592423
132MP0001881_abnormal_mammary_gland0.46023078
133MP0003959_abnormal_lean_body0.45611625
134MP0000639_abnormal_adrenal_gland0.44728347
135MP0004264_abnormal_extraembryonic_tissu0.44515906
136MP0005166_decreased_susceptibility_to0.43279737
137MP0005330_cardiomyopathy0.42698535
138MP0002168_other_aberrant_phenotype0.41865292
139MP0003724_increased_susceptibility_to0.41835737
140MP0004147_increased_porphyrin_level0.40646193
141MP0005464_abnormal_platelet_physiology0.39830571
142MP0004782_abnormal_surfactant_physiolog0.39413075
143MP0008961_abnormal_basal_metabolism0.39205310
144MP0008872_abnormal_physiological_respon0.38626020
145MP0008874_decreased_physiological_sensi0.38541156
146MP0000579_abnormal_nail_morphology0.37244486
147MP0000538_abnormal_urinary_bladder0.36573993
148MP0008873_increased_physiological_sensi0.36098210

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.10871383
2Nemaline bodies (HP:0003798)6.91116415
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.78812221
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.38455843
5Intrahepatic cholestasis (HP:0001406)6.26723817
6Deep venous thrombosis (HP:0002625)6.26186122
7Exercise-induced myalgia (HP:0003738)5.86686274
8Type 1 muscle fiber predominance (HP:0003803)5.72430655
9Xanthomatosis (HP:0000991)5.64316621
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.60397764
11Hypobetalipoproteinemia (HP:0003563)5.22726621
12Exercise-induced muscle cramps (HP:0003710)5.06006157
13Prolonged partial thromboplastin time (HP:0003645)4.97128496
14Hyperlipoproteinemia (HP:0010980)4.85537588
15Hyperammonemia (HP:0001987)4.77419291
16Complement deficiency (HP:0004431)4.69025931
17Muscle hypertrophy of the lower extremities (HP:0008968)4.55540868
18Ketosis (HP:0001946)4.54932602
19Hyperglycinuria (HP:0003108)4.46514077
20Rhabdomyolysis (HP:0003201)4.35958341
21Abnormality of glycine metabolism (HP:0010895)4.31350900
22Abnormality of serine family amino acid metabolism (HP:0010894)4.31350900
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.30618235
24Calf muscle hypertrophy (HP:0008981)4.29358006
25Hypoglycemic coma (HP:0001325)4.27947352
26Hypolipoproteinemia (HP:0010981)4.18218604
27Hyperglycinemia (HP:0002154)4.17365083
28Epidermoid cyst (HP:0200040)4.02402555
29Abnormality of fatty-acid metabolism (HP:0004359)3.91420625
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.88420848
31Hypoalphalipoproteinemia (HP:0003233)3.85888505
32Abnormality of the common coagulation pathway (HP:0010990)3.81671200
33Sudden death (HP:0001699)3.79367915
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.76702169
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.75496989
36Distal arthrogryposis (HP:0005684)3.74692835
37Abnormality of the calf musculature (HP:0001430)3.71307334
38Ketoacidosis (HP:0001993)3.70956117
39Fat malabsorption (HP:0002630)3.70137225
40Bundle branch block (HP:0011710)3.68293257
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.60572025
42EMG: myopathic abnormalities (HP:0003458)3.57597570
43Joint hemorrhage (HP:0005261)3.56896208
44Hyporeflexia of lower limbs (HP:0002600)3.47280089
45Rimmed vacuoles (HP:0003805)3.46440729
46Asymmetric septal hypertrophy (HP:0001670)3.43752468
47Abnormality of methionine metabolism (HP:0010901)3.38124814
48Muscle fiber splitting (HP:0003555)3.36852907
49Abnormality of complement system (HP:0005339)3.33903597
50Abnormality of the intrinsic pathway (HP:0010989)3.31220761
51Hypercholesterolemia (HP:0003124)3.24656614
52Round ear (HP:0100830)3.18143213
53Gout (HP:0001997)3.17300816
54Myopathic facies (HP:0002058)3.15937674
55Neck muscle weakness (HP:0000467)3.13990640
56Conjugated hyperbilirubinemia (HP:0002908)3.12594200
57Subaortic stenosis (HP:0001682)3.10755898
58Abnormality of the left ventricular outflow tract (HP:0011103)3.10755898
59Abnormality of purine metabolism (HP:0004352)3.06638981
60Hyperbilirubinemia (HP:0002904)3.04388000
61Abnormality of dicarboxylic acid metabolism (HP:0010995)3.03708401
62Dicarboxylic aciduria (HP:0003215)3.03708401
63Delayed CNS myelination (HP:0002188)2.97122430
64Abnormality of nucleobase metabolism (HP:0010932)2.95041705
65Ulnar deviation of the wrist (HP:0003049)2.90781832
66Abnormality of serum amino acid levels (HP:0003112)2.90275291
67Metabolic acidosis (HP:0001942)2.89368469
68Abnormality of skeletal muscle fiber size (HP:0012084)2.88025983
69Myocardial infarction (HP:0001658)2.79000663
70Steatorrhea (HP:0002570)2.77174521
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.77168973
72Hepatocellular carcinoma (HP:0001402)2.77069404
73Abnormality of pyrimidine metabolism (HP:0004353)2.71847153
74Heart block (HP:0012722)2.70567176
75Ventricular tachycardia (HP:0004756)2.68985338
76Skin nodule (HP:0200036)2.63635977
77Vascular calcification (HP:0004934)2.62928472
78Lethargy (HP:0001254)2.61403839
79Generalized aminoaciduria (HP:0002909)2.58217642
80Muscle stiffness (HP:0003552)2.58014624
81Increased variability in muscle fiber diameter (HP:0003557)2.57245654
82Dilated cardiomyopathy (HP:0001644)2.54034972
83Spastic diplegia (HP:0001264)2.52625358
84Abnormal atrioventricular conduction (HP:0005150)2.52424980
85Abnormality of proline metabolism (HP:0010907)2.51390929
86Hydroxyprolinuria (HP:0003080)2.51390929
87EMG: neuropathic changes (HP:0003445)2.44090062
88Hypoglycemic seizures (HP:0002173)2.41674329
89Esophageal varix (HP:0002040)2.41256844
90Cardiovascular calcification (HP:0011915)2.40888303
91Atrioventricular block (HP:0001678)2.37725425
92Difficulty running (HP:0009046)2.36628378
93Acanthocytosis (HP:0001927)2.33943300
94Systemic lupus erythematosus (HP:0002725)2.32988772
95Lipoatrophy (HP:0100578)2.32726863
96Myotonia (HP:0002486)2.32021710
97Absent phalangeal crease (HP:0006109)2.30839353
98Cerebral edema (HP:0002181)2.29538316
99Spontaneous abortion (HP:0005268)2.27854879
100Proximal tubulopathy (HP:0000114)2.27748527
101Abnormal gallbladder morphology (HP:0012437)2.27511309
102Mildly elevated creatine phosphokinase (HP:0008180)2.27379262
103Increased purine levels (HP:0004368)2.26428721
104Hyperuricemia (HP:0002149)2.26428721
105Sensorimotor neuropathy (HP:0007141)2.26307702
106Neonatal onset (HP:0003623)2.26161322
107Vomiting (HP:0002013)2.25164125
108Cholelithiasis (HP:0001081)2.24362882
109Late onset (HP:0003584)2.23799159
110Frequent falls (HP:0002359)2.23435552
111Distal lower limb muscle weakness (HP:0009053)2.20707622
112Pancreatitis (HP:0001733)2.20045652
113Malnutrition (HP:0004395)2.19954847
114Myoglobinuria (HP:0002913)2.18143922
115Palpitations (HP:0001962)2.17258259
116Back pain (HP:0003418)2.15029383
117Cholecystitis (HP:0001082)2.13172708
118Abnormal gallbladder physiology (HP:0012438)2.13172708
119Abnormal cartilage morphology (HP:0002763)2.12351664
120Irritability (HP:0000737)2.11724354
121Alkalosis (HP:0001948)2.11718114
122Hyperkalemia (HP:0002153)2.11226618
123Mitral stenosis (HP:0001718)2.07783404
124Generalized muscle weakness (HP:0003324)2.07146569
125Amyloidosis (HP:0011034)2.05815003
126Hemorrhage of the eye (HP:0011885)2.03097967
127Malignant hyperthermia (HP:0002047)1.99314701
128Areflexia of lower limbs (HP:0002522)1.97306852
129Increased connective tissue (HP:0009025)1.97263321
130Brushfield spots (HP:0001088)1.95362566
131Calcaneovalgus deformity (HP:0001848)1.94993570
132Ventricular arrhythmia (HP:0004308)1.94589219
133Glomerulonephritis (HP:0000099)1.93805384
134Hypertriglyceridemia (HP:0002155)1.93095705
135Hyperinsulinemic hypoglycemia (HP:0000825)1.92573352
136Cerebral palsy (HP:0100021)1.92444907
137Glycosuria (HP:0003076)1.91430080
138Abnormality of urine glucose concentration (HP:0011016)1.91430080
139Oligomenorrhea (HP:0000876)1.90994458
140Syncope (HP:0001279)1.90236297
141Abnormal finger flexion creases (HP:0006143)1.87278941
142Enlarged kidneys (HP:0000105)1.87015059
143Abnormality of the gallbladder (HP:0005264)1.84959729
144Atrial fibrillation (HP:0005110)1.84016400
145Nausea (HP:0002018)1.83491989
146Renal cortical cysts (HP:0000803)1.83431643
147Deformed tarsal bones (HP:0008119)1.82207168
148Increased serum pyruvate (HP:0003542)1.81987303
149Limb-girdle muscle atrophy (HP:0003797)1.80258685
150Abnormality of transition element cation homeostasis (HP:0011030)1.78818511
151Rickets (HP:0002748)1.76611667
152Right ventricular cardiomyopathy (HP:0011663)1.75970928
153Elevated hepatic transaminases (HP:0002910)1.75505099
154Hypochromic microcytic anemia (HP:0004840)1.75394214
155Opisthotonus (HP:0002179)1.74973441
156Polycythemia (HP:0001901)1.72597971
157Menorrhagia (HP:0000132)1.72025508
158Hyperglycemia (HP:0003074)1.71872015
159Poikilocytosis (HP:0004447)1.71299672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.52284919
2BCKDK6.15854905
3SIK14.16200405
4ERN13.89580701
5TRIB33.67662267
6FGFR42.98952686
7PKN22.88993192
8MST1R2.47615848
9FRK1.91411861
10INSRR1.89036759
11LATS11.86795948
12PTK61.85672849
13TRPM71.85479957
14FGFR21.79161375
15LMTK21.78985420
16MAPKAPK31.78962980
17ERBB41.70659733
18RIPK11.57950195
19FLT31.56789852
20TAOK31.53951475
21CAMK1D1.51680660
22PDK31.46261908
23PDK41.46261908
24ERBB31.46064721
25MAPK111.33981609
26LIMK11.32633796
27MAP3K71.32360872
28MAP2K41.32047340
29PIK3CG1.31517827
30MARK11.27770144
31NEK91.27434487
32WNK41.27163554
33DMPK1.14248124
34EPHB11.13802214
35MET1.13554994
36PRKAA21.12284812
37MUSK1.10572327
38LRRK21.03299724
39TGFBR21.00516279
40JAK20.99656866
41TYK20.99496820
42PDK20.98094951
43PDGFRA0.98023007
44TIE10.96647489
45AKT30.94478237
46ERBB20.91226149
47ABL20.90250127
48MAP3K100.89940403
49KDR0.89676791
50TTN0.89038563
51PINK10.88392999
52CAMK1G0.88060587
53PIK3CA0.87149913
54DAPK20.86748484
55GRK10.84559917
56CAMK2D0.82924877
57RET0.82345408
58SGK20.82049932
59MYLK0.80250968
60JAK10.79621748
61MAP3K30.79273124
62TBK10.79134556
63MAP3K20.78750324
64MAP2K30.78486440
65PDPK10.78373870
66PTK20.77476715
67MAP3K60.76091652
68MAP2K10.75834871
69NLK0.74553074
70CDK60.74301966
71OXSR10.71642656
72PRKAA10.68493509
73MAPK120.66948500
74GSK3A0.66648733
75BMPR1B0.65792510
76FGFR30.65245887
77MAP2K20.64594757
78GRK60.63588040
79DYRK1B0.62391371
80MAPK70.62270246
81DDR20.61946561
82FER0.61038471
83NEK10.61024235
84PRKCZ0.60951817
85PRKACG0.60729596
86STK390.60357460
87PRKG10.59072715
88SGK30.57530299
89CAMK2A0.57014237
90PRKCE0.56448822
91CAMK2G0.56362187
92PRKACA0.55801026
93PRKG20.55234384
94EIF2AK30.55009834
95EEF2K0.54749817
96SGK2230.54658869
97SGK4940.54658869
98PDK10.54478128
99MAPK40.52904845
100BMX0.51863875
101BCR0.51433399
102PAK30.49685940
103WNK10.49590282
104PRKD10.48706746
105KSR20.48606710
106AKT20.48227984
107LATS20.47430442
108ROCK10.47398624
109MAP3K110.46806473
110EPHB20.44262841
111MAP3K40.44037393
112CAMK40.43798112
113FGFR10.43325403
114RPS6KB10.43199509
115MAPK130.42198778
116CAMKK10.42140197
117CAMK2B0.42061185
118MAP4K20.41189117
119EPHA30.41069575
120EIF2AK10.40652471
121PRKCQ0.39493894
122IGF1R0.38856756
123MTOR0.38154787
124RPS6KA30.37880937
125CAMK10.37853846
126PDGFRB0.37756395
127MAP2K60.37293400
128PAK20.35975567
129STK38L0.35547722
130CSK0.33584743
131WNK30.33441511
132PHKG20.33072345
133PHKG10.33072345
134PRKACB0.32921345
135PRKCH0.32571376
136MAP3K10.32289583
137SCYL20.31843788
138MAPKAPK50.31786597
139TGFBR10.31114548
140STK30.29789220
141SGK10.29188265
142STK240.25984806
143NTRK30.25601174
144ADRBK20.25362966

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.96363147
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.85345225
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12505586
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97832913
5Fatty acid degradation_Homo sapiens_hsa000712.87147001
6Arginine biosynthesis_Homo sapiens_hsa002202.80402906
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74127473
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66244247
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60921032
10Tryptophan metabolism_Homo sapiens_hsa003802.56340865
11Propanoate metabolism_Homo sapiens_hsa006402.51008689
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29734845
13Butanoate metabolism_Homo sapiens_hsa006502.22791585
14Complement and coagulation cascades_Homo sapiens_hsa046102.20714798
15Fatty acid metabolism_Homo sapiens_hsa012122.20317627
16PPAR signaling pathway_Homo sapiens_hsa033202.11700730
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08867789
18Peroxisome_Homo sapiens_hsa041462.06384525
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01296187
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95156142
21Caffeine metabolism_Homo sapiens_hsa002321.79761905
22beta-Alanine metabolism_Homo sapiens_hsa004101.78539893
23Chemical carcinogenesis_Homo sapiens_hsa052041.73012801
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72040203
25Histidine metabolism_Homo sapiens_hsa003401.69636002
26Pyruvate metabolism_Homo sapiens_hsa006201.66268414
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64197884
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62840592
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58353672
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.56464236
31Bile secretion_Homo sapiens_hsa049761.53798921
32Sulfur metabolism_Homo sapiens_hsa009201.51954257
33Retinol metabolism_Homo sapiens_hsa008301.47285037
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44214113
35Fat digestion and absorption_Homo sapiens_hsa049751.42857697
36Carbon metabolism_Homo sapiens_hsa012001.42686077
37Fatty acid elongation_Homo sapiens_hsa000621.42409613
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.39259346
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38768687
40Dilated cardiomyopathy_Homo sapiens_hsa054141.38575417
41Phenylalanine metabolism_Homo sapiens_hsa003601.37746012
42Selenocompound metabolism_Homo sapiens_hsa004501.36614490
43Starch and sucrose metabolism_Homo sapiens_hsa005001.33566985
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31178741
45Staphylococcus aureus infection_Homo sapiens_hsa051501.30401556
46Tyrosine metabolism_Homo sapiens_hsa003501.25533971
47Biosynthesis of amino acids_Homo sapiens_hsa012301.24317603
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19350825
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16139236
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.14788268
51Folate biosynthesis_Homo sapiens_hsa007901.10957320
52ABC transporters_Homo sapiens_hsa020101.09476423
53Cardiac muscle contraction_Homo sapiens_hsa042601.06594053
54Circadian rhythm_Homo sapiens_hsa047100.99324487
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.99036984
56Fatty acid biosynthesis_Homo sapiens_hsa000610.97963956
57Steroid biosynthesis_Homo sapiens_hsa001000.94345513
58Glycerolipid metabolism_Homo sapiens_hsa005610.94126201
59Vitamin digestion and absorption_Homo sapiens_hsa049770.91632340
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91261926
61Arginine and proline metabolism_Homo sapiens_hsa003300.90774248
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86100235
63Lysine degradation_Homo sapiens_hsa003100.85296331
64Arachidonic acid metabolism_Homo sapiens_hsa005900.84407379
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.84232595
66Sulfur relay system_Homo sapiens_hsa041220.82583109
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78550218
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75196598
69Glutathione metabolism_Homo sapiens_hsa004800.74953808
70Vitamin B6 metabolism_Homo sapiens_hsa007500.67134401
71Pentose phosphate pathway_Homo sapiens_hsa000300.62646510
72ECM-receptor interaction_Homo sapiens_hsa045120.60437267
73Renin secretion_Homo sapiens_hsa049240.59897027
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.58019966
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54446512
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.46111732
77Metabolic pathways_Homo sapiens_hsa011000.42747085
78Insulin resistance_Homo sapiens_hsa049310.41155704
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40514392
80Ether lipid metabolism_Homo sapiens_hsa005650.35025038
81Calcium signaling pathway_Homo sapiens_hsa040200.31646521
82Galactose metabolism_Homo sapiens_hsa000520.29331768
83Fructose and mannose metabolism_Homo sapiens_hsa000510.28350776
84One carbon pool by folate_Homo sapiens_hsa006700.26805801
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26165290
86Oxytocin signaling pathway_Homo sapiens_hsa049210.24337679
87AMPK signaling pathway_Homo sapiens_hsa041520.23583549
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22827005
89Glucagon signaling pathway_Homo sapiens_hsa049220.20854015
90Focal adhesion_Homo sapiens_hsa045100.19021556
91Prion diseases_Homo sapiens_hsa050200.18688244
92Serotonergic synapse_Homo sapiens_hsa047260.17777821
93Insulin secretion_Homo sapiens_hsa049110.16617663
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.16569719
95Platelet activation_Homo sapiens_hsa046110.14876560
96Tight junction_Homo sapiens_hsa045300.13669825
97Protein digestion and absorption_Homo sapiens_hsa049740.12805849
98Linoleic acid metabolism_Homo sapiens_hsa005910.09710084
99Renin-angiotensin system_Homo sapiens_hsa046140.06914418
100Insulin signaling pathway_Homo sapiens_hsa049100.05360591
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04893590
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03840627
103Mineral absorption_Homo sapiens_hsa049780.02880242
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.00526400
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00109235
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1483712
107Lysosome_Homo sapiens_hsa04142-0.1439269
108Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1399288
109Hepatitis C_Homo sapiens_hsa05160-0.1370631
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1364260
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1193948
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1096138
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1031767
114Amoebiasis_Homo sapiens_hsa05146-0.1015488
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1014732
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0942877
117Pancreatic secretion_Homo sapiens_hsa04972-0.0718347
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0134273
119Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0107805

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