AK3P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)5.24733336
2positive regulation of action potential (GO:0045760)5.20870352
3tachykinin receptor signaling pathway (GO:0007217)4.98337006
4positive regulation of uterine smooth muscle contraction (GO:0070474)4.74812200
5aggressive behavior (GO:0002118)4.56799925
6DNA double-strand break processing (GO:0000729)4.26945532
7resolution of meiotic recombination intermediates (GO:0000712)4.19138015
8replication fork processing (GO:0031297)3.98034886
9drinking behavior (GO:0042756)3.84834445
10positive regulation of digestive system process (GO:0060456)3.84725184
11response to pheromone (GO:0019236)3.76510162
12negative regulation of dendrite development (GO:2000171)3.76134682
13regulation of uterine smooth muscle contraction (GO:0070472)3.59195127
14regulation of collateral sprouting (GO:0048670)3.56574995
15regulation of action potential (GO:0098900)3.48324352
16kinetochore organization (GO:0051383)3.47031046
17maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42991222
18chromatin remodeling at centromere (GO:0031055)3.42223368
19DNA ligation (GO:0006266)3.34592306
20histone exchange (GO:0043486)3.33375018
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.32620514
22mitotic metaphase plate congression (GO:0007080)3.31164919
23mitotic spindle checkpoint (GO:0071174)3.29841231
24protein localization to kinetochore (GO:0034501)3.24970096
25neurotransmitter catabolic process (GO:0042135)3.24803120
26mitotic G2/M transition checkpoint (GO:0044818)3.20450909
27spindle checkpoint (GO:0031577)3.20231899
28inositol phosphate catabolic process (GO:0071545)3.19003436
29kinetochore assembly (GO:0051382)3.15617163
30CENP-A containing nucleosome assembly (GO:0034080)3.13947424
31sister chromatid segregation (GO:0000819)3.12966517
32mitotic sister chromatid cohesion (GO:0007064)3.12148371
33metaphase plate congression (GO:0051310)3.10876935
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10780961
35negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10780961
36negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10780961
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.10780961
38negative regulation of sister chromatid segregation (GO:0033046)3.10780961
39DNA topological change (GO:0006265)3.10355540
40mitotic spindle assembly checkpoint (GO:0007094)3.07436816
41microtubule anchoring (GO:0034453)3.06917019
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06685486
43DNA catabolic process, exonucleolytic (GO:0000738)3.05394036
44regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03434762
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03434762
46spindle assembly checkpoint (GO:0071173)3.02943051
47male meiosis (GO:0007140)3.00733773
48somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99811405
49somatic hypermutation of immunoglobulin genes (GO:0016446)2.99811405
50negative regulation of chromosome segregation (GO:0051985)2.99806113
51DNA unwinding involved in DNA replication (GO:0006268)2.99644399
52histone H2A acetylation (GO:0043968)2.99335256
53neural tube formation (GO:0001841)2.96291798
54regulation of centriole replication (GO:0046599)2.96055143
55mitotic G2 DNA damage checkpoint (GO:0007095)2.95334232
56recombinational repair (GO:0000725)2.94883972
57peptidyl-histidine modification (GO:0018202)2.92358818
58protein K11-linked deubiquitination (GO:0035871)2.91806369
59double-strand break repair via homologous recombination (GO:0000724)2.91528042
60negative regulation of protein oligomerization (GO:0032460)2.90162411
61cell wall macromolecule catabolic process (GO:0016998)2.88849443
62DNA replication-dependent nucleosome assembly (GO:0006335)2.88395642
63DNA replication-dependent nucleosome organization (GO:0034723)2.88395642
64positive regulation of vascular permeability (GO:0043117)2.87936454
65mitotic sister chromatid segregation (GO:0000070)2.87624040
66negative regulation of DNA recombination (GO:0045910)2.87450823
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.86805646
68purine nucleobase biosynthetic process (GO:0009113)2.84809548
69regulation of sister chromatid segregation (GO:0033045)2.84771886
70regulation of mitotic sister chromatid separation (GO:0010965)2.84771886
71regulation of mitotic sister chromatid segregation (GO:0033047)2.84771886
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.83465800
73somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82299183
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82299183
75isotype switching (GO:0045190)2.82299183
76centriole assembly (GO:0098534)2.80852416
77retinal cone cell development (GO:0046549)2.79863805
78presynaptic membrane assembly (GO:0097105)2.79192102
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78791546
80regulation of non-canonical Wnt signaling pathway (GO:2000050)2.77977209
81DNA damage response, detection of DNA damage (GO:0042769)2.77924680
82DNA methylation involved in gamete generation (GO:0043046)2.75988743
83base-excision repair, AP site formation (GO:0006285)2.75979399
84mitotic recombination (GO:0006312)2.72723220
85negative regulation of membrane potential (GO:0045837)2.72660333
86C4-dicarboxylate transport (GO:0015740)2.71892935
87microtubule depolymerization (GO:0007019)2.71680622
88pyrimidine nucleotide catabolic process (GO:0006244)2.70889709
89protein K11-linked ubiquitination (GO:0070979)2.70646874
90polyol catabolic process (GO:0046174)2.70620754
91male meiosis I (GO:0007141)2.70401768
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.66151705
93regulation of translation, ncRNA-mediated (GO:0045974)2.66151705
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66151705
95attachment of spindle microtubules to kinetochore (GO:0008608)2.64541073
96positive regulation of catecholamine secretion (GO:0033605)2.62955772
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.61127308
98protein sumoylation (GO:0016925)2.57578053
99DNA replication-independent nucleosome assembly (GO:0006336)2.55758930
100DNA replication-independent nucleosome organization (GO:0034724)2.55758930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.24744370
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.21247144
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.19217308
4ZNF274_21170338_ChIP-Seq_K562_Hela3.58096586
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10674193
6VDR_22108803_ChIP-Seq_LS180_Human3.08005512
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82982337
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74197722
9TAF15_26573619_Chip-Seq_HEK293_Human2.67330052
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66878862
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.57942502
12FUS_26573619_Chip-Seq_HEK293_Human2.56919625
13GBX2_23144817_ChIP-Seq_PC3_Human2.53828233
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50281585
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47790991
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44561258
17P300_19829295_ChIP-Seq_ESCs_Human2.31116669
18EWS_26573619_Chip-Seq_HEK293_Human2.13920703
19IGF1R_20145208_ChIP-Seq_DFB_Human2.07885176
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92150103
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85994370
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83218501
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82362392
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79110932
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.75380609
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73582244
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.71006514
28BCAT_22108803_ChIP-Seq_LS180_Human1.63651823
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.62779789
30ELK1_19687146_ChIP-ChIP_HELA_Human1.61383674
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60514156
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57962464
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57623238
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56778433
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56645076
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52681950
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49624610
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.49468774
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.49436416
40CBP_20019798_ChIP-Seq_JUKART_Human1.47235490
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47235490
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44935551
43SMAD4_21799915_ChIP-Seq_A2780_Human1.43742863
44MYC_18940864_ChIP-ChIP_HL60_Human1.43316332
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43300427
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42436622
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39284853
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.37488530
49STAT3_23295773_ChIP-Seq_U87_Human1.34163756
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.33767710
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30895496
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29025022
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.25606295
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23972019
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23302445
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23215816
57TCF4_22108803_ChIP-Seq_LS180_Human1.22756292
58EZH2_22144423_ChIP-Seq_EOC_Human1.22125606
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21786655
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.19977159
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19872752
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18581070
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17319474
64ER_23166858_ChIP-Seq_MCF-7_Human1.15432518
65TP53_22573176_ChIP-Seq_HFKS_Human1.15281785
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.14201551
67AR_25329375_ChIP-Seq_VCAP_Human1.13814073
68SOX9_26525672_Chip-Seq_HEART_Mouse1.12761009
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12653763
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11942888
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.11931445
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11834316
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11827359
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.08616381
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08431738
76FOXP3_21729870_ChIP-Seq_TREG_Human1.07432353
77RUNX2_22187159_ChIP-Seq_PCA_Human1.07263002
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.05334540
79VDR_23849224_ChIP-Seq_CD4+_Human1.04806779
80TCF4_23295773_ChIP-Seq_U87_Human1.04354074
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02672541
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02627215
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.01992012
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01248185
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.00380874
86AR_21572438_ChIP-Seq_LNCaP_Human0.99160830
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98696534
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97348068
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96841980
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96302177
91SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96177204
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95782715
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95656241
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95656241
95NANOG_19829295_ChIP-Seq_ESCs_Human0.93699166
96SOX2_19829295_ChIP-Seq_ESCs_Human0.93699166
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93665077
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.93275007
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.92843645
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91458622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.65531154
2MP0008877_abnormal_DNA_methylation3.44935242
3MP0001529_abnormal_vocalization3.38077312
4MP0010094_abnormal_chromosome_stability3.16373685
5MP0001984_abnormal_olfaction3.00822899
6MP0001968_abnormal_touch/_nociception2.83517398
7MP0005367_renal/urinary_system_phenotyp2.83272354
8MP0000516_abnormal_urinary_system2.83272354
9MP0003890_abnormal_embryonic-extraembry2.36633917
10MP0002735_abnormal_chemical_nociception2.26714313
11MP0008058_abnormal_DNA_repair2.24059932
12MP0003111_abnormal_nucleus_morphology2.20685867
13MP0003693_abnormal_embryo_hatching2.18094514
14MP0006292_abnormal_olfactory_placode2.12627526
15MP0001177_atelectasis2.04019062
16MP0008789_abnormal_olfactory_epithelium2.00003480
17MP0008057_abnormal_DNA_replication1.95728761
18MP0005394_taste/olfaction_phenotype1.86931693
19MP0005499_abnormal_olfactory_system1.86931693
20MP0000778_abnormal_nervous_system1.86538673
21MP0004147_increased_porphyrin_level1.86510211
22MP0004215_abnormal_myocardial_fiber1.81047084
23MP0003121_genomic_imprinting1.77957257
24MP0002234_abnormal_pharynx_morphology1.77840279
25MP0008007_abnormal_cellular_replicative1.70014752
26MP0002751_abnormal_autonomic_nervous1.66584550
27MP0003718_maternal_effect1.61828646
28MP0003122_maternal_imprinting1.55840425
29MP0000427_abnormal_hair_cycle1.55264407
30MP0006276_abnormal_autonomic_nervous1.51641002
31MP0002734_abnormal_mechanical_nocicepti1.50865625
32MP0002277_abnormal_respiratory_mucosa1.49922933
33MP0003567_abnormal_fetal_cardiomyocyte1.48358960
34MP0004270_analgesia1.47909252
35MP0003119_abnormal_digestive_system1.46618223
36MP0008932_abnormal_embryonic_tissue1.44690307
37MP0001293_anophthalmia1.44326868
38MP0002102_abnormal_ear_morphology1.43577997
39MP0004859_abnormal_synaptic_plasticity1.42661522
40MP0008872_abnormal_physiological_respon1.40993238
41MP0009745_abnormal_behavioral_response1.39496616
42MP0002653_abnormal_ependyma_morphology1.38950275
43MP0003077_abnormal_cell_cycle1.36711628
44MP0005551_abnormal_eye_electrophysiolog1.34448937
45MP0002938_white_spotting1.33968610
46MP0002160_abnormal_reproductive_system1.31345926
47MP0002572_abnormal_emotion/affect_behav1.28378417
48MP0004924_abnormal_behavior1.24641876
49MP0005386_behavior/neurological_phenoty1.24641876
50MP0006054_spinal_hemorrhage1.22922327
51MP0001188_hyperpigmentation1.22036852
52MP0002233_abnormal_nose_morphology1.20044520
53MP0009697_abnormal_copulation1.18977051
54MP0003937_abnormal_limbs/digits/tail_de1.18324104
55MP0001486_abnormal_startle_reflex1.17170421
56MP0002210_abnormal_sex_determination1.14695961
57MP0003880_abnormal_central_pattern1.14249516
58MP0009703_decreased_birth_body1.13071318
59MP0009046_muscle_twitch1.12516799
60MP0001929_abnormal_gametogenesis1.12451554
61MP0003698_abnormal_male_reproductive1.10919265
62MP0003787_abnormal_imprinting1.10728772
63MP0004957_abnormal_blastocyst_morpholog1.10285823
64MP0003635_abnormal_synaptic_transmissio1.04774552
65MP0010307_abnormal_tumor_latency1.02261377
66MP0008770_decreased_survivor_rate1.01884010
67MP0004133_heterotaxia0.95544592
68MP0002272_abnormal_nervous_system0.93238749
69MP0003861_abnormal_nervous_system0.93132723
70MP0003786_premature_aging0.92917655
71MP0001727_abnormal_embryo_implantation0.91103694
72MP0000537_abnormal_urethra_morphology0.90523727
73MP0000631_abnormal_neuroendocrine_gland0.90435802
74MP0000653_abnormal_sex_gland0.90316910
75MP0001145_abnormal_male_reproductive0.90240982
76MP0006072_abnormal_retinal_apoptosis0.86693181
77MP0000049_abnormal_middle_ear0.84691620
78MP0001286_abnormal_eye_development0.84178004
79MP0005253_abnormal_eye_physiology0.83894618
80MP0001502_abnormal_circadian_rhythm0.83844549
81MP0002557_abnormal_social/conspecific_i0.83842860
82MP0001501_abnormal_sleep_pattern0.80848889
83MP0000647_abnormal_sebaceous_gland0.79578092
84MP0003935_abnormal_craniofacial_develop0.79428227
85MP0001119_abnormal_female_reproductive0.78369309
86MP0001299_abnormal_eye_distance/0.77804155
87MP0002752_abnormal_somatic_nervous0.77582065
88MP0005645_abnormal_hypothalamus_physiol0.76044283
89MP0003656_abnormal_erythrocyte_physiolo0.75979962
90MP0003137_abnormal_impulse_conducting0.75701501
91MP0002063_abnormal_learning/memory/cond0.75131525
92MP0002067_abnormal_sensory_capabilities0.74872715
93MP0001697_abnormal_embryo_size0.74051837
94MP0001730_embryonic_growth_arrest0.73572588
95MP0002111_abnormal_tail_morphology0.73465011
96MP0005410_abnormal_fertilization0.73462925
97MP0003755_abnormal_palate_morphology0.71233972
98MP0005187_abnormal_penis_morphology0.69459234
99MP0006035_abnormal_mitochondrial_morpho0.69136932
100MP0002184_abnormal_innervation0.69008605

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.23100638
2Retinal dysplasia (HP:0007973)3.82834495
3Amyotrophic lateral sclerosis (HP:0007354)3.58496985
4Type II lissencephaly (HP:0007260)3.45487364
5Oligodactyly (hands) (HP:0001180)3.44625059
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.35584893
7Abnormality of chromosome stability (HP:0003220)3.27057542
8Intestinal atresia (HP:0011100)3.25537025
9Meckel diverticulum (HP:0002245)3.21903781
10Abnormality of the parathyroid morphology (HP:0011766)3.18576783
11Abnormality of the ileum (HP:0001549)3.12471997
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09296354
13Embryonal renal neoplasm (HP:0011794)2.89495404
14Pancreatic fibrosis (HP:0100732)2.81444642
15Chromsome breakage (HP:0040012)2.78553552
16Limb dystonia (HP:0002451)2.78404488
17True hermaphroditism (HP:0010459)2.77648754
18Abnormality of the preputium (HP:0100587)2.72085425
19Molar tooth sign on MRI (HP:0002419)2.70055354
20Abnormality of midbrain morphology (HP:0002418)2.70055354
21Neoplasm of the adrenal cortex (HP:0100641)2.69472045
22Pancreatic cysts (HP:0001737)2.67075152
23Sclerocornea (HP:0000647)2.64505081
24Nephroblastoma (Wilms tumor) (HP:0002667)2.64473094
25Duodenal stenosis (HP:0100867)2.60583096
26Small intestinal stenosis (HP:0012848)2.60583096
27Atrophy/Degeneration involving motor neurons (HP:0007373)2.59607116
28Abnormality of the duodenum (HP:0002246)2.58007471
29Oligodactyly (HP:0012165)2.52368213
30Chronic hepatic failure (HP:0100626)2.52178330
31Dandy-Walker malformation (HP:0001305)2.48584630
32Abnormal lung lobation (HP:0002101)2.48536113
33Aqueductal stenosis (HP:0002410)2.47913648
34Renal hypoplasia (HP:0000089)2.45458896
35Volvulus (HP:0002580)2.42332802
36Anencephaly (HP:0002323)2.37631643
37Hepatoblastoma (HP:0002884)2.34883550
38Sloping forehead (HP:0000340)2.31055997
39Hypoplastic female external genitalia (HP:0012815)2.26951918
40Anal atresia (HP:0002023)2.25578273
41Glioma (HP:0009733)2.24304472
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.23371711
43Labial hypoplasia (HP:0000066)2.22838702
44Occipital encephalocele (HP:0002085)2.21987293
45Rhabdomyosarcoma (HP:0002859)2.21117535
46Clubbing of toes (HP:0100760)2.20783182
47Abnormality of the lower motor neuron (HP:0002366)2.19769770
48Postaxial foot polydactyly (HP:0001830)2.16301051
49Bifid tongue (HP:0010297)2.15179415
50Abnormality of the carotid arteries (HP:0005344)2.14755172
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.14547973
52Tubulointerstitial nephritis (HP:0001970)2.12756126
53Cerebellar dysplasia (HP:0007033)2.10745686
54Lissencephaly (HP:0001339)2.09065320
55Small hand (HP:0200055)2.07077538
56Nephronophthisis (HP:0000090)2.05809079
57Narrow forehead (HP:0000341)2.03867705
58Astigmatism (HP:0000483)2.02305855
59Long clavicles (HP:0000890)2.02037566
60Triphalangeal thumb (HP:0001199)1.99623941
61Cone-rod dystrophy (HP:0000548)1.95918800
62Preaxial hand polydactyly (HP:0001177)1.95856459
63Gastroesophageal reflux (HP:0002020)1.95780249
64Birth length less than 3rd percentile (HP:0003561)1.94326799
65Polyphagia (HP:0002591)1.94207947
66Thyroid-stimulating hormone excess (HP:0002925)1.92799447
67Embryonal neoplasm (HP:0002898)1.92201577
68Neoplasm of the adrenal gland (HP:0100631)1.91665096
69Aplasia/hypoplasia of the uterus (HP:0008684)1.87115682
70Oligohydramnios (HP:0001562)1.86226094
71Hyperglycinemia (HP:0002154)1.84686619
72Congenital hepatic fibrosis (HP:0002612)1.82135337
73Renal cortical cysts (HP:0000803)1.81775084
74Dyschromatopsia (HP:0007641)1.80186090
75Hyperventilation (HP:0002883)1.79237124
76Methylmalonic acidemia (HP:0002912)1.78347822
77Cystic liver disease (HP:0006706)1.78143647
78Cupped ear (HP:0000378)1.77351925
79Supernumerary spleens (HP:0009799)1.76951512
80Anal stenosis (HP:0002025)1.75966507
81Atonic seizures (HP:0010819)1.75916389
82Gait imbalance (HP:0002141)1.75809265
83Bile duct proliferation (HP:0001408)1.75781966
84Abnormal biliary tract physiology (HP:0012439)1.75781966
85Absent speech (HP:0001344)1.74404258
86Hypothermia (HP:0002045)1.74149125
87Absent forearm bone (HP:0003953)1.74095204
88Aplasia involving forearm bones (HP:0009822)1.74095204
89Chorioretinal coloboma (HP:0000567)1.73697405
90Enlarged kidneys (HP:0000105)1.73216943
91Hypoplasia of the uterus (HP:0000013)1.72915331
92Abnormality of the astrocytes (HP:0100707)1.72862182
93Astrocytoma (HP:0009592)1.72862182
94Abnormality of the labia (HP:0000058)1.72694450
95Abnormal hair whorl (HP:0010721)1.72337547
96Postaxial hand polydactyly (HP:0001162)1.70723803
97Abnormality of the renal medulla (HP:0100957)1.70133409
98Myelodysplasia (HP:0002863)1.69885707
99Abnormality of the renal cortex (HP:0011035)1.69846592
100Medial flaring of the eyebrow (HP:0010747)1.69737261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.80519263
2BUB13.98281982
3MAPK133.74374808
4FRK3.20698621
5MKNK22.70566308
6SRPK12.55295662
7MARK12.50355535
8BCR2.38725555
9TTK2.26610621
10ACVR1B2.25540617
11BMPR1B2.23041055
12BCKDK2.19441262
13ZAK2.18530619
14TNIK2.09951759
15BRSK22.07035168
16PRKD31.95886051
17MKNK11.92758398
18CASK1.92133684
19PLK41.83560183
20PLK31.69710313
21CDC71.64207059
22CCNB11.61933146
23NUAK11.61412963
24TRIM281.57827961
25PLK11.47284763
26FGFR21.44405837
27ATR1.39678548
28NEK11.32025512
29MAP4K21.29983153
30PBK1.25862779
31ERBB31.25393389
32PINK11.23776841
33TGFBR11.20442304
34WEE11.17040489
35TESK21.14244488
36CSNK1G11.06000363
37PKN11.05538822
38EIF2AK30.93855963
39CSNK1G20.93084811
40EIF2AK10.92585590
41TSSK60.92409622
42PDK20.87911144
43ATM0.86303669
44TAOK30.82611610
45EIF2AK20.80697045
46CAMKK20.80529035
47BRD40.79550200
48PAK30.77564777
49CSNK1G30.76666980
50CHEK20.71535440
51PLK20.70991982
52STK38L0.70000510
53GRK10.69795824
54MST40.69330857
55PHKG20.69058685
56PHKG10.69058685
57ERBB40.65965729
58IRAK20.65289995
59PRKCE0.64798781
60MAP2K70.64629125
61PRKCG0.63610901
62MAP3K40.63461608
63MINK10.61482980
64DYRK30.57244592
65DYRK20.54853118
66CSNK1A10.54662685
67BRSK10.53857535
68DYRK1A0.53805272
69CSNK1A1L0.53679430
70CAMK2A0.53446155
71ADRBK20.49689688
72VRK10.49471263
73PAK60.49249710
74EPHA40.48405031
75NTRK20.45776834
76PRKDC0.43723326
77PRKCZ0.43588516
78CDK10.42856747
79CHEK10.42630196
80CAMK2B0.42357269
81SIK30.42230737
82CDK180.41916258
83AURKB0.40598622
84CLK10.40598003
85CAMK2D0.39541311
86FLT30.38445414
87PTK2B0.37028332
88PNCK0.36849552
89CDK150.35887478
90ADRBK10.35669931
91CDK11A0.32900993
92CSNK1D0.32380303
93CDK190.30880684
94CSNK2A10.29859956
95NME10.29268356
96UHMK10.28531727
97INSRR0.28145590
98OXSR10.26572662
99CDK70.26159175
100PRKACB0.25989486

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.44768553
2Non-homologous end-joining_Homo sapiens_hsa034503.24142331
3Base excision repair_Homo sapiens_hsa034103.15623364
4Homologous recombination_Homo sapiens_hsa034402.97403094
5DNA replication_Homo sapiens_hsa030302.94126956
6Mismatch repair_Homo sapiens_hsa034302.58458334
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38188495
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.26867615
9Propanoate metabolism_Homo sapiens_hsa006402.20516848
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11308090
11Sulfur metabolism_Homo sapiens_hsa009202.06884409
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02927972
13Cell cycle_Homo sapiens_hsa041102.01799262
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91922823
15Proteasome_Homo sapiens_hsa030501.88125757
16Basal transcription factors_Homo sapiens_hsa030221.79828786
17Fatty acid elongation_Homo sapiens_hsa000621.78394535
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72886912
19Steroid biosynthesis_Homo sapiens_hsa001001.71477245
20Nicotine addiction_Homo sapiens_hsa050331.60070048
21One carbon pool by folate_Homo sapiens_hsa006701.56958829
22Selenocompound metabolism_Homo sapiens_hsa004501.54825007
23Oocyte meiosis_Homo sapiens_hsa041141.52495219
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52418186
25Nucleotide excision repair_Homo sapiens_hsa034201.50753279
26RNA transport_Homo sapiens_hsa030131.50435025
27Taste transduction_Homo sapiens_hsa047421.49258256
28RNA degradation_Homo sapiens_hsa030181.46652943
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43978337
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41871311
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40006872
32Butanoate metabolism_Homo sapiens_hsa006501.39984251
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.36451042
34Spliceosome_Homo sapiens_hsa030401.27500200
35mRNA surveillance pathway_Homo sapiens_hsa030151.27123921
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.25438529
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23655042
38Olfactory transduction_Homo sapiens_hsa047401.19200708
39p53 signaling pathway_Homo sapiens_hsa041151.19116951
40Fatty acid metabolism_Homo sapiens_hsa012121.15524044
41Purine metabolism_Homo sapiens_hsa002301.11030508
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09794332
43Circadian rhythm_Homo sapiens_hsa047101.06653476
44Peroxisome_Homo sapiens_hsa041461.06064883
45Pyrimidine metabolism_Homo sapiens_hsa002401.05243099
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02885856
47Hedgehog signaling pathway_Homo sapiens_hsa043400.97342528
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95734009
49RNA polymerase_Homo sapiens_hsa030200.95640094
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90318679
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87433322
52Pyruvate metabolism_Homo sapiens_hsa006200.87161839
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87072615
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86449878
55Phototransduction_Homo sapiens_hsa047440.85008667
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81039087
57Lysine degradation_Homo sapiens_hsa003100.78368672
58Fatty acid degradation_Homo sapiens_hsa000710.77899720
59ABC transporters_Homo sapiens_hsa020100.75753337
60Vitamin digestion and absorption_Homo sapiens_hsa049770.74426216
61TGF-beta signaling pathway_Homo sapiens_hsa043500.71751879
62Nitrogen metabolism_Homo sapiens_hsa009100.71415175
63Linoleic acid metabolism_Homo sapiens_hsa005910.69517219
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65660586
65Long-term depression_Homo sapiens_hsa047300.65646606
66Ether lipid metabolism_Homo sapiens_hsa005650.65639114
67Folate biosynthesis_Homo sapiens_hsa007900.62436683
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60414578
69Fatty acid biosynthesis_Homo sapiens_hsa000610.58874155
70Retinol metabolism_Homo sapiens_hsa008300.58059679
71Glutamatergic synapse_Homo sapiens_hsa047240.57216758
72Wnt signaling pathway_Homo sapiens_hsa043100.56510218
73Cocaine addiction_Homo sapiens_hsa050300.54867508
74Basal cell carcinoma_Homo sapiens_hsa052170.54049793
75Dopaminergic synapse_Homo sapiens_hsa047280.53206607
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.52621764
77Amphetamine addiction_Homo sapiens_hsa050310.52193791
78Tryptophan metabolism_Homo sapiens_hsa003800.51739379
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50094182
80Hippo signaling pathway_Homo sapiens_hsa043900.49966443
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49004483
82Metabolic pathways_Homo sapiens_hsa011000.49002627
83Protein export_Homo sapiens_hsa030600.48788858
84Fat digestion and absorption_Homo sapiens_hsa049750.47209805
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47176607
86Arginine and proline metabolism_Homo sapiens_hsa003300.46264248
87Glutathione metabolism_Homo sapiens_hsa004800.45895613
88Calcium signaling pathway_Homo sapiens_hsa040200.45182793
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45005336
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44428767
91Regulation of autophagy_Homo sapiens_hsa041400.44169803
92Parkinsons disease_Homo sapiens_hsa050120.43401984
93Circadian entrainment_Homo sapiens_hsa047130.40380036
94N-Glycan biosynthesis_Homo sapiens_hsa005100.36700280
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34905449
96beta-Alanine metabolism_Homo sapiens_hsa004100.33773439
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33481121
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32207090
99Tight junction_Homo sapiens_hsa045300.29098759
100GABAergic synapse_Homo sapiens_hsa047270.28302071

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