AK3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T-helper cell differentiation (GO:0042093)5.26894700
2CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)5.26894700
3regulation of hippo signaling (GO:0035330)5.01926019
4peptidyl-threonine dephosphorylation (GO:0035970)4.92264121
5oxygen transport (GO:0015671)4.85725879
6mitotic cell cycle arrest (GO:0071850)4.66492949
7T cell differentiation involved in immune response (GO:0002292)4.60925127
8alpha-beta T cell differentiation involved in immune response (GO:0002293)4.60925127
9alpha-beta T cell activation involved in immune response (GO:0002287)4.60925127
10positive regulation of granulocyte differentiation (GO:0030854)4.38030957
11regulation of mitotic spindle checkpoint (GO:1903504)4.21102983
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.21102983
13response to gravity (GO:0009629)4.17534763
14regulation of memory T cell differentiation (GO:0043380)4.16783543
15endoderm formation (GO:0001706)4.04724899
16CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.99600580
17establishment of protein localization to Golgi (GO:0072600)3.92714655
18cytoplasmic mRNA processing body assembly (GO:0033962)3.90081762
19regulation of regulatory T cell differentiation (GO:0045589)3.87304213
20negative regulation of T-helper cell differentiation (GO:0045623)3.69466035
21negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.69466035
22protein targeting to Golgi (GO:0000042)3.67926907
23regulation of histone H3-K27 methylation (GO:0061085)3.62772903
24gas transport (GO:0015669)3.61675678
25CD4-positive, alpha-beta T cell activation (GO:0035710)3.54478496
26alpha-beta T cell differentiation (GO:0046632)3.49151316
27protein K11-linked deubiquitination (GO:0035871)3.36140553
28cellular response to zinc ion (GO:0071294)3.33282474
29negative regulation of meiotic cell cycle (GO:0051447)3.30020612
30thyroid hormone generation (GO:0006590)3.25369306
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17617776
32protein localization to Golgi apparatus (GO:0034067)3.17485810
33gamma-aminobutyric acid transport (GO:0015812)3.15676692
34negative regulation of alpha-beta T cell differentiation (GO:0046639)3.14969867
35thyroid hormone metabolic process (GO:0042403)3.14933652
36positive regulation of NIK/NF-kappaB signaling (GO:1901224)3.10318657
37spliceosomal tri-snRNP complex assembly (GO:0000244)3.10171433
38S-adenosylmethionine metabolic process (GO:0046500)3.08753079
39positive regulation of natural killer cell differentiation (GO:0032825)3.06516770
40DNA double-strand break processing (GO:0000729)3.06055535
41inactivation of MAPK activity (GO:0000188)3.02584257
42glycine transport (GO:0015816)2.99699909
43positive regulation of T cell cytokine production (GO:0002726)2.98095419
44necrotic cell death (GO:0070265)2.97698525
45regulation of gamma-delta T cell differentiation (GO:0045586)2.95285135
46programmed necrotic cell death (GO:0097300)2.89672710
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.88824068
48transepithelial transport (GO:0070633)2.88479281
49intra-Golgi vesicle-mediated transport (GO:0006891)2.86058323
50regulation of establishment of cell polarity (GO:2000114)2.82177711
51somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80445659
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80445659
53isotype switching (GO:0045190)2.80445659
54sleep (GO:0030431)2.80002353
55myoblast migration (GO:0051451)2.75633126
56negative regulation of complement activation (GO:0045916)2.74705479
57alpha-beta T cell activation (GO:0046631)2.73368955
58neural crest cell development (GO:0014032)2.73257210
59translesion synthesis (GO:0019985)2.73120080
60inositol phosphate-mediated signaling (GO:0048016)2.71870247
61detection of light stimulus involved in sensory perception (GO:0050962)2.71193887
62detection of light stimulus involved in visual perception (GO:0050908)2.71193887
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64579899
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.64055196
65sulfate transport (GO:0008272)2.63426470
66lung lobe morphogenesis (GO:0060463)2.63290458
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.63214176
68embryonic process involved in female pregnancy (GO:0060136)2.61986727
69regulation of NIK/NF-kappaB signaling (GO:1901222)2.60833432
70regulation of T cell receptor signaling pathway (GO:0050856)2.58319361
71lymph node development (GO:0048535)2.57894030
72sphingoid metabolic process (GO:0046519)2.57736998
73L-fucose catabolic process (GO:0042355)2.57296225
74fucose catabolic process (GO:0019317)2.57296225
75L-fucose metabolic process (GO:0042354)2.57296225
76platelet dense granule organization (GO:0060155)2.56924598
77arginine catabolic process (GO:0006527)2.56044818
78regulation of T cell mediated cytotoxicity (GO:0001914)2.53789836
79energy homeostasis (GO:0097009)2.53319173
80regulation of germinal center formation (GO:0002634)2.50908722
81nodal signaling pathway (GO:0038092)2.50610216
82positive regulation of protein homodimerization activity (GO:0090073)2.50520126
83pericardium development (GO:0060039)2.49883935
84retinal cone cell development (GO:0046549)2.48995128
85response to cold (GO:0009409)2.47629137
86regulation of spindle checkpoint (GO:0090231)2.47356887
87arginine metabolic process (GO:0006525)2.47264663
88regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.46374620
89positive regulation of mRNA catabolic process (GO:0061014)2.45213597
90positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.44930880
91regulation of granulocyte differentiation (GO:0030852)2.40612380
92anterior/posterior axis specification, embryo (GO:0008595)2.40264972
93negative regulation of protein activation cascade (GO:2000258)2.39241290
94protein K6-linked ubiquitination (GO:0085020)2.37955526
95replicative senescence (GO:0090399)2.37085605
96positive regulation of defense response to virus by host (GO:0002230)2.36082753
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.35281944
98interferon-gamma production (GO:0032609)2.34492322
99tolerance induction (GO:0002507)2.34306960
100piRNA metabolic process (GO:0034587)2.33897783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93420424
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73857980
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.69354805
4ZNF274_21170338_ChIP-Seq_K562_Hela3.27139626
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26052062
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.25585216
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.24107981
8FLI1_27457419_Chip-Seq_LIVER_Mouse3.22520741
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.03701075
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61578936
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61016523
12AR_21572438_ChIP-Seq_LNCaP_Human2.54901726
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.44173815
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.31408162
15TAF15_26573619_Chip-Seq_HEK293_Human2.30732480
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.08651110
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05898698
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00616504
19SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89919850
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.83360948
21EZH2_27294783_Chip-Seq_NPCs_Mouse1.82072698
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80119491
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72696933
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68066724
25AHR_22903824_ChIP-Seq_MCF-7_Human1.67841273
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65745640
27GATA3_26560356_Chip-Seq_TH2_Human1.62638190
28CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.62004056
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.61540934
30GBX2_23144817_ChIP-Seq_PC3_Human1.60525068
31MYB_26560356_Chip-Seq_TH1_Human1.60102286
32VDR_22108803_ChIP-Seq_LS180_Human1.58891024
33RUNX_20019798_ChIP-Seq_JUKART_Human1.57376038
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.57113645
35TP53_16413492_ChIP-PET_HCT116_Human1.55574447
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47564874
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.43880511
38RXR_22108803_ChIP-Seq_LS180_Human1.41528183
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40118730
40CJUN_26792858_Chip-Seq_BT549_Human1.39949889
41GATA3_27048872_Chip-Seq_THYMUS_Human1.35915023
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.34489733
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32011655
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31954700
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.31000449
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30569003
47MYB_26560356_Chip-Seq_TH2_Human1.30375732
48EWS_26573619_Chip-Seq_HEK293_Human1.29406090
49IRF1_19129219_ChIP-ChIP_H3396_Human1.29045288
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27944372
51FUS_26573619_Chip-Seq_HEK293_Human1.26249858
52OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26073151
53SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25174435
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22572221
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22572221
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20164450
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19742390
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16938308
59CBP_20019798_ChIP-Seq_JUKART_Human1.16938308
60TP53_22573176_ChIP-Seq_HFKS_Human1.14356086
61P300_19829295_ChIP-Seq_ESCs_Human1.13831072
62BCAT_22108803_ChIP-Seq_LS180_Human1.11704511
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10992598
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.10702272
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10007117
66STAT3_23295773_ChIP-Seq_U87_Human1.08815400
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08755498
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06886889
69HOXB7_26014856_ChIP-Seq_BT474_Human1.06498633
70P53_22387025_ChIP-Seq_ESCs_Mouse1.06351997
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.06016420
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05340297
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04794683
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03821918
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03518122
76SMAD4_21799915_ChIP-Seq_A2780_Human1.02693651
77ELK1_19687146_ChIP-ChIP_HELA_Human1.02057146
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00855027
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00113621
80WT1_19549856_ChIP-ChIP_CCG9911_Human0.99696269
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.98910230
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98212943
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97670196
84NANOG_18555785_Chip-Seq_ESCs_Mouse0.97090787
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96449130
86SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95677944
87BRD4_25478319_ChIP-Seq_HGPS_Human0.95583118
88TCF4_23295773_ChIP-Seq_U87_Human0.95522297
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94020443
90CDX2_22108803_ChIP-Seq_LS180_Human0.93906604
91ESR1_20079471_ChIP-ChIP_T-47D_Human0.93677941
92IGF1R_20145208_ChIP-Seq_DFB_Human0.92201827
93ETV1_20927104_ChIP-Seq_GIST48_Human0.91369192
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.90766754
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.89914769
96EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88143665
97ZFX_18555785_Chip-Seq_ESCs_Mouse0.88074167
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88041461
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.87987505
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87380735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.96614508
2MP0003724_increased_susceptibility_to4.92423015
3MP0003950_abnormal_plasma_membrane4.66618324
4MP0000569_abnormal_digit_pigmentation3.69519185
5MP0004264_abnormal_extraembryonic_tissu3.05731647
6MP0003828_pulmonary_edema2.68040919
7MP0003300_gastrointestinal_ulcer2.63912358
8MP0000013_abnormal_adipose_tissue2.62651924
9MP0006072_abnormal_retinal_apoptosis2.57756331
10MP0001986_abnormal_taste_sensitivity2.48321385
11MP0002876_abnormal_thyroid_physiology2.22309490
12MP0008995_early_reproductive_senescence2.14998315
13MP0001873_stomach_inflammation2.14383832
14MP0005167_abnormal_blood-brain_barrier2.02477759
15MP0001501_abnormal_sleep_pattern1.98740157
16MP0004043_abnormal_pH_regulation1.96792703
17MP0009384_cardiac_valve_regurgitation1.91398534
18MP0003866_abnormal_defecation1.89504983
19MP0002166_altered_tumor_susceptibility1.80518877
20MP0005253_abnormal_eye_physiology1.73343270
21MP0003011_delayed_dark_adaptation1.65079365
22MP0005360_urolithiasis1.64768768
23MP0005671_abnormal_response_to1.59561976
24MP0005670_abnormal_white_adipose1.57768755
25MP0003763_abnormal_thymus_physiology1.57426900
26MP0008877_abnormal_DNA_methylation1.55355044
27MP0008775_abnormal_heart_ventricle1.53233833
28MP0003656_abnormal_erythrocyte_physiolo1.51693979
29MP0001533_abnormal_skeleton_physiology1.45576473
30MP0005000_abnormal_immune_tolerance1.43214987
31MP0008057_abnormal_DNA_replication1.41586140
32MP0002006_tumorigenesis1.39883582
33MP0001502_abnormal_circadian_rhythm1.37738900
34MP0003252_abnormal_bile_duct1.35837893
35MP0005083_abnormal_biliary_tract1.35293825
36MP0008875_abnormal_xenobiotic_pharmacok1.29298601
37MP0009764_decreased_sensitivity_to1.25576009
38MP0001879_abnormal_lymphatic_vessel1.25112036
39MP0000538_abnormal_urinary_bladder1.24853966
40MP0004133_heterotaxia1.23049590
41MP0008961_abnormal_basal_metabolism1.22856192
42MP0001800_abnormal_humoral_immune1.21659780
43MP0005075_abnormal_melanosome_morpholog1.20366942
44MP0005551_abnormal_eye_electrophysiolog1.20273026
45MP0005174_abnormal_tail_pigmentation1.19475093
46MP0003718_maternal_effect1.18392163
47MP0004484_altered_response_of1.18241118
48MP0003436_decreased_susceptibility_to1.18226609
49MP0009780_abnormal_chondrocyte_physiolo1.15307976
50MP0000537_abnormal_urethra_morphology1.15018726
51MP0004134_abnormal_chest_morphology1.13197463
52MP0003878_abnormal_ear_physiology1.10776815
53MP0005377_hearing/vestibular/ear_phenot1.10776815
54MP0000427_abnormal_hair_cycle1.09861642
55MP0004130_abnormal_muscle_cell1.09644144
56MP0009840_abnormal_foam_cell1.06819238
57MP0005645_abnormal_hypothalamus_physiol1.00846104
58MP0002723_abnormal_immune_serum0.98217994
59MP0004947_skin_inflammation0.98118777
60MP0010386_abnormal_urinary_bladder0.97193971
61MP0001819_abnormal_immune_cell0.94698279
62MP0003943_abnormal_hepatobiliary_system0.94196192
63MP0000230_abnormal_systemic_arterial0.94181211
64MP0000465_gastrointestinal_hemorrhage0.93768833
65MP0000371_diluted_coat_color0.93219875
66MP0002822_catalepsy0.90240347
67MP0002452_abnormal_antigen_presenting0.89858259
68MP0004084_abnormal_cardiac_muscle0.89784953
69MP0004147_increased_porphyrin_level0.87809318
70MP0000003_abnormal_adipose_tissue0.87450803
71MP0010329_abnormal_lipoprotein_level0.86846509
72MP0002420_abnormal_adaptive_immunity0.86496751
73MP0009053_abnormal_anal_canal0.85795512
74MP0000015_abnormal_ear_pigmentation0.85017715
75MP0002136_abnormal_kidney_physiology0.84907650
76MP0003137_abnormal_impulse_conducting0.84886901
77MP0004036_abnormal_muscle_relaxation0.82305760
78MP0009115_abnormal_fat_cell0.81542440
79MP0002751_abnormal_autonomic_nervous0.81182261
80MP0006292_abnormal_olfactory_placode0.77402167
81MP0004381_abnormal_hair_follicle0.75344985
82MP0000647_abnormal_sebaceous_gland0.73171729
83MP0000249_abnormal_blood_vessel0.72830874
84MP0001542_abnormal_bone_strength0.72007694
85MP0005646_abnormal_pituitary_gland0.72006394
86MP0001270_distended_abdomen0.71605056
87MP0002135_abnormal_kidney_morphology0.71544741
88MP0002928_abnormal_bile_duct0.69520162
89MP0003937_abnormal_limbs/digits/tail_de0.69444932
90MP0004215_abnormal_myocardial_fiber0.68039651
91MP0002102_abnormal_ear_morphology0.67370820
92MP0003195_calcinosis0.65914040
93MP0005085_abnormal_gallbladder_physiolo0.65728548
94MP0001845_abnormal_inflammatory_respons0.64384565
95MP0000383_abnormal_hair_follicle0.64040466
96MP0002638_abnormal_pupillary_reflex0.64002346
97MP0000613_abnormal_salivary_gland0.63920191
98MP0002653_abnormal_ependyma_morphology0.63186495
99MP0002735_abnormal_chemical_nociception0.63007970
100MP0002234_abnormal_pharynx_morphology0.62846521

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)7.59040124
2Prostate neoplasm (HP:0100787)6.54804815
3IgG deficiency (HP:0004315)4.42765605
4Abnormality of the prostate (HP:0008775)3.35819278
5Genetic anticipation (HP:0003743)3.26514459
6Albinism (HP:0001022)3.09746804
7Congenital stationary night blindness (HP:0007642)3.04821734
8Poor eye contact (HP:0000817)3.01097200
9Epidermoid cyst (HP:0200040)3.01035312
10Clumsiness (HP:0002312)3.00458665
11Pancreatic cysts (HP:0001737)2.95699109
12Azoospermia (HP:0000027)2.93575054
13Aortic aneurysm (HP:0004942)2.89229176
14Hypoplasia of the pons (HP:0012110)2.85119902
15Partial agenesis of the corpus callosum (HP:0001338)2.82503688
16Abnormal spermatogenesis (HP:0008669)2.81425626
17Aplasia/Hypoplasia of the tibia (HP:0005772)2.75582542
18Abnormality of the renal cortex (HP:0011035)2.74696190
19Abnormality of the pons (HP:0007361)2.73288805
20Abnormality of the nasal septum (HP:0000419)2.72256053
21Acanthocytosis (HP:0001927)2.70816478
22Unilateral renal agenesis (HP:0000122)2.65904937
23Ectopic kidney (HP:0000086)2.61610525
24Tented upper lip vermilion (HP:0010804)2.53355393
25Short tibia (HP:0005736)2.51624574
26Submucous cleft hard palate (HP:0000176)2.51481318
27Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48359862
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48292428
29Abnormality of B cell number (HP:0010975)2.47049361
30Progressive microcephaly (HP:0000253)2.46098966
31Abnormality of male internal genitalia (HP:0000022)2.35392744
32Abnormal social behavior (HP:0012433)2.33271226
33Impaired social interactions (HP:0000735)2.33271226
34Optic nerve hypoplasia (HP:0000609)2.31140852
35Parakeratosis (HP:0001036)2.30444957
36True hermaphroditism (HP:0010459)2.29735197
37Chronic hepatic failure (HP:0100626)2.26833285
38IgA deficiency (HP:0002720)2.26345744
39Hyperventilation (HP:0002883)2.21325645
40Progressive inability to walk (HP:0002505)2.17658811
41Abnormality of DNA repair (HP:0003254)2.17169905
42Chromsome breakage (HP:0040012)2.13889587
43Absent thumb (HP:0009777)2.12560274
44Pancreatic fibrosis (HP:0100732)2.10826519
45Abnormal hemoglobin (HP:0011902)2.10135197
46Atonic seizures (HP:0010819)2.04377400
47Stomatitis (HP:0010280)2.03082144
48Aortic regurgitation (HP:0001659)2.02895603
49B lymphocytopenia (HP:0010976)2.02277463
50Fair hair (HP:0002286)2.00565310
51Tubular atrophy (HP:0000092)1.97524789
52Hemiparesis (HP:0001269)1.95697835
53Biconcave vertebral bodies (HP:0004586)1.94993406
54Glucose intolerance (HP:0000833)1.94021957
55Renal cortical cysts (HP:0000803)1.93016973
56Duplicated collecting system (HP:0000081)1.90920319
57Stillbirth (HP:0003826)1.89080371
58Increased IgM level (HP:0003496)1.84318264
59Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84073653
60Depressed nasal tip (HP:0000437)1.83373238
61Beaking of vertebral bodies (HP:0004568)1.82244295
62Alveolar cell carcinoma (HP:0006519)1.81161121
63Abnormality of the axillary hair (HP:0100134)1.80651541
64Abnormality of secondary sexual hair (HP:0009888)1.80651541
65Abnormality of the renal collecting system (HP:0004742)1.79704438
66Generalized hypopigmentation of hair (HP:0011358)1.78919004
67Nephrogenic diabetes insipidus (HP:0009806)1.78398537
68Neoplasm of the tracheobronchial system (HP:0100552)1.78023282
69Congenital primary aphakia (HP:0007707)1.76544302
70Poor head control (HP:0002421)1.75911397
71Barrel-shaped chest (HP:0001552)1.75797825
72T lymphocytopenia (HP:0005403)1.72424436
73Glioma (HP:0009733)1.72154872
74Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69952315
75Short 1st metacarpal (HP:0010034)1.69690099
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69690099
77Abnormality of the fingertips (HP:0001211)1.69290627
78Hematochezia (HP:0002573)1.69282339
79Conical tooth (HP:0000698)1.68123608
80Inability to walk (HP:0002540)1.67345993
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66041767
82Abnormality of alanine metabolism (HP:0010916)1.66041767
83Hyperalaninemia (HP:0003348)1.66041767
84Bone cyst (HP:0012062)1.65865978
85Broad foot (HP:0001769)1.65635403
86Abnormality of T cell number (HP:0011839)1.65476449
87Hypomagnesemia (HP:0002917)1.65335676
88Carpal bone hypoplasia (HP:0001498)1.64657497
89Heterotopia (HP:0002282)1.64559449
90Abnormality of the ileum (HP:0001549)1.64478445
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63733355
92Abnormality of the periventricular white matter (HP:0002518)1.63694474
93Long nose (HP:0003189)1.63185644
94Abnormality of T cell physiology (HP:0011840)1.61645615
95Gait imbalance (HP:0002141)1.60689059
96Anhidrosis (HP:0000970)1.60233561
97Absent speech (HP:0001344)1.59896922
98Abnormality of the distal phalanges of the toes (HP:0010182)1.59853049
99Hamartoma of the eye (HP:0010568)1.58647578
100Hypoalbuminemia (HP:0003073)1.58283208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.06640184
2MAP2K24.00052949
3ZAK3.77072585
4NME13.55333880
5TXK3.29731917
6BRD42.77047894
7TAOK32.68573033
8MAP3K62.34677783
9MST42.15130320
10FRK2.09709371
11MAP3K142.08614912
12EPHA32.06519988
13ERBB31.89424053
14MAP3K41.87479152
15MAP4K21.71184373
16WNK41.70938144
17GRK11.65607403
18BRSK21.64208168
19MAP2K61.63590558
20TLK11.60912660
21TRPM71.58735750
22MAPKAPK31.44347706
23PTK2B1.40148706
24IKBKB1.37040712
25ITK1.27875474
26MAP2K11.24684353
27CDK121.23832343
28LMTK21.21215170
29STK101.10110022
30MAPK71.10056546
31TNIK1.06667096
32ICK1.03384085
33MKNK20.96534256
34PRKG20.94503887
35PIM20.94357607
36TRIM280.92663279
37DYRK30.91034439
38RPS6KA20.90754133
39ERBB40.90438286
40MAPK130.87591356
41SYK0.84329549
42PDGFRB0.83291988
43TEC0.83158952
44TNK20.81355807
45GRK60.81175051
46WNK10.81144281
47MAP2K40.80640803
48BCKDK0.79726326
49WEE10.77836801
50PRKAA10.73597369
51STK380.71341128
52MAPK110.69380920
53STK390.69221378
54MYLK0.68961199
55JAK10.68746061
56CASK0.68670910
57PRKD20.66463658
58LATS10.66069207
59FER0.66012423
60EPHA20.65948410
61PIK3CA0.65194724
62CHUK0.63712984
63IGF1R0.62874517
64ZAP700.62631567
65LIMK10.61311837
66ADRBK20.58989497
67ERBB20.58916413
68ACVR1B0.58592850
69PHKG10.58410230
70PHKG20.58410230
71EEF2K0.58243189
72MAP2K30.57742422
73MET0.55736833
74STK30.53174995
75RPS6KA10.51631949
76PRKAA20.50982657
77PDGFRA0.50362256
78ABL10.48761493
79PINK10.48588439
80ADRBK10.48270236
81OXSR10.47841083
82MAP2K70.46707879
83RPS6KA60.44176064
84RPS6KA40.42422897
85PRKCE0.41662256
86DAPK20.41274309
87IKBKE0.39137593
88LCK0.39063250
89RPS6KA50.38934688
90MAPK10.38862464
91CDK30.36729214
92PIM10.36681656
93MTOR0.35925117
94BTK0.35493857
95PRKCZ0.35207172
96RPS6KC10.35131703
97RPS6KL10.35131703
98CDK90.34082031
99MAP3K50.33857251
100MAPK30.32723767

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.70003747
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.63580955
3Mineral absorption_Homo sapiens_hsa049782.36772222
4Nitrogen metabolism_Homo sapiens_hsa009102.01796976
5TNF signaling pathway_Homo sapiens_hsa046682.01232972
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86859076
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79810438
8Linoleic acid metabolism_Homo sapiens_hsa005911.77769839
9Regulation of autophagy_Homo sapiens_hsa041401.77019418
10Homologous recombination_Homo sapiens_hsa034401.75419885
11Nicotine addiction_Homo sapiens_hsa050331.64492474
12Primary immunodeficiency_Homo sapiens_hsa053401.61208947
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59921137
14T cell receptor signaling pathway_Homo sapiens_hsa046601.58875414
15Morphine addiction_Homo sapiens_hsa050321.58775353
16Circadian rhythm_Homo sapiens_hsa047101.55183583
17Taste transduction_Homo sapiens_hsa047421.54383153
18Retinol metabolism_Homo sapiens_hsa008301.50285682
19Glycerolipid metabolism_Homo sapiens_hsa005611.48516741
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46657444
21Lysine degradation_Homo sapiens_hsa003101.45479903
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42649246
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40267440
24Butanoate metabolism_Homo sapiens_hsa006501.37357642
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.36926944
26Caffeine metabolism_Homo sapiens_hsa002321.31306424
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.29370547
28Selenocompound metabolism_Homo sapiens_hsa004501.22501481
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20811459
30Basal transcription factors_Homo sapiens_hsa030221.16668240
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12584374
32RNA polymerase_Homo sapiens_hsa030201.06933257
33Ether lipid metabolism_Homo sapiens_hsa005651.06750118
34Phototransduction_Homo sapiens_hsa047441.06319620
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05743964
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04810922
37Sphingolipid metabolism_Homo sapiens_hsa006001.04437977
38Malaria_Homo sapiens_hsa051441.04392490
39ABC transporters_Homo sapiens_hsa020101.04146923
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03405386
41GABAergic synapse_Homo sapiens_hsa047271.00491875
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99066319
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.97981011
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94402852
45Olfactory transduction_Homo sapiens_hsa047400.91706481
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91327025
47Serotonergic synapse_Homo sapiens_hsa047260.91296722
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88266293
49Herpes simplex infection_Homo sapiens_hsa051680.87656614
50Tryptophan metabolism_Homo sapiens_hsa003800.85313905
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82790729
52TGF-beta signaling pathway_Homo sapiens_hsa043500.82619436
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82565049
54Chemical carcinogenesis_Homo sapiens_hsa052040.82554423
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81920637
56cAMP signaling pathway_Homo sapiens_hsa040240.81430854
57Hepatitis C_Homo sapiens_hsa051600.80321426
58Fat digestion and absorption_Homo sapiens_hsa049750.79335088
59Histidine metabolism_Homo sapiens_hsa003400.78410945
60Arachidonic acid metabolism_Homo sapiens_hsa005900.75968635
61Hematopoietic cell lineage_Homo sapiens_hsa046400.75401672
62p53 signaling pathway_Homo sapiens_hsa041150.75349342
63Insulin resistance_Homo sapiens_hsa049310.69938681
64Renin secretion_Homo sapiens_hsa049240.69488174
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.67385156
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67001032
67Platelet activation_Homo sapiens_hsa046110.66407353
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66251820
69Salivary secretion_Homo sapiens_hsa049700.65262245
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64982085
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.62486761
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61050197
73FoxO signaling pathway_Homo sapiens_hsa040680.60708336
74Legionellosis_Homo sapiens_hsa051340.58915829
75Tight junction_Homo sapiens_hsa045300.57944221
76Osteoclast differentiation_Homo sapiens_hsa043800.57914410
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.56242073
78MicroRNAs in cancer_Homo sapiens_hsa052060.55550757
79Pertussis_Homo sapiens_hsa051330.55025776
80Measles_Homo sapiens_hsa051620.54648237
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53472884
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.53000956
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51420755
84Shigellosis_Homo sapiens_hsa051310.50863808
85Pancreatic secretion_Homo sapiens_hsa049720.50715792
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.49426776
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.48573601
88Circadian entrainment_Homo sapiens_hsa047130.48498985
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48000478
90Calcium signaling pathway_Homo sapiens_hsa040200.47431765
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47396153
92Bile secretion_Homo sapiens_hsa049760.46341760
93Toxoplasmosis_Homo sapiens_hsa051450.46090885
94Small cell lung cancer_Homo sapiens_hsa052220.45953677
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.45029944
96Peroxisome_Homo sapiens_hsa041460.44654676
97Cocaine addiction_Homo sapiens_hsa050300.44345216
98Amphetamine addiction_Homo sapiens_hsa050310.43876058
99Hippo signaling pathway_Homo sapiens_hsa043900.42564149
100Insulin secretion_Homo sapiens_hsa049110.42359891

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