AK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.20968562
2L-phenylalanine catabolic process (GO:0006559)6.20968562
3L-phenylalanine metabolic process (GO:0006558)6.17129670
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.17129670
5serine family amino acid catabolic process (GO:0009071)6.13944192
6lysine metabolic process (GO:0006553)5.98735035
7lysine catabolic process (GO:0006554)5.98735035
8glyoxylate metabolic process (GO:0046487)5.97599117
9cysteine metabolic process (GO:0006534)5.92555916
10aromatic amino acid family catabolic process (GO:0009074)5.81277497
11glycine metabolic process (GO:0006544)5.59241206
12urate metabolic process (GO:0046415)5.45345187
13serine family amino acid metabolic process (GO:0009069)5.43588319
14indole-containing compound catabolic process (GO:0042436)5.43336283
15indolalkylamine catabolic process (GO:0046218)5.43336283
16tryptophan catabolic process (GO:0006569)5.43336283
17kynurenine metabolic process (GO:0070189)5.36611270
18serine family amino acid biosynthetic process (GO:0009070)5.33739580
19amino-acid betaine metabolic process (GO:0006577)5.21861174
20homocysteine metabolic process (GO:0050667)5.18448148
21tryptophan metabolic process (GO:0006568)5.12237527
22drug catabolic process (GO:0042737)4.82568008
23sulfur amino acid catabolic process (GO:0000098)4.76827580
24folic acid metabolic process (GO:0046655)4.72954331
25drug transmembrane transport (GO:0006855)4.61962434
26bile acid biosynthetic process (GO:0006699)4.61824340
27alpha-amino acid catabolic process (GO:1901606)4.61547644
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.59035269
29aromatic amino acid family metabolic process (GO:0009072)4.58577799
30fructose metabolic process (GO:0006000)4.56596594
31urea cycle (GO:0000050)4.56554996
32urea metabolic process (GO:0019627)4.56554996
33aspartate family amino acid catabolic process (GO:0009068)4.42072596
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.41426177
35alpha-linolenic acid metabolic process (GO:0036109)4.41338858
36cellular amino acid catabolic process (GO:0009063)4.37088956
37exogenous drug catabolic process (GO:0042738)4.36795453
38glutamate metabolic process (GO:0006536)4.30354286
39establishment of integrated proviral latency (GO:0075713)4.28035960
40cellular modified amino acid catabolic process (GO:0042219)4.22285005
41cellular ketone body metabolic process (GO:0046950)4.21734622
422-oxoglutarate metabolic process (GO:0006103)4.21183854
43nitrogen cycle metabolic process (GO:0071941)4.19393127
44drug transport (GO:0015893)4.17872082
45IMP biosynthetic process (GO:0006188)4.13324079
46dicarboxylic acid biosynthetic process (GO:0043650)4.08526528
47L-serine metabolic process (GO:0006563)4.05455168
48negative regulation of fibrinolysis (GO:0051918)3.99592433
49carnitine metabolic process (GO:0009437)3.98726077
50short-chain fatty acid metabolic process (GO:0046459)3.96193462
51bile acid metabolic process (GO:0008206)3.94962412
52negative regulation of cholesterol transport (GO:0032375)3.92188687
53negative regulation of sterol transport (GO:0032372)3.92188687
54phosphate ion transmembrane transport (GO:0035435)3.89575730
55phosphate ion transport (GO:0006817)3.84449641
56chromatin remodeling at centromere (GO:0031055)3.83147058
57acetyl-CoA metabolic process (GO:0006084)3.82081088
58mitotic metaphase plate congression (GO:0007080)3.81727041
59protein carboxylation (GO:0018214)3.79245632
60peptidyl-glutamic acid carboxylation (GO:0017187)3.79245632
61tyrosine metabolic process (GO:0006570)3.77201834
62regulation of protein activation cascade (GO:2000257)3.76731377
63high-density lipoprotein particle remodeling (GO:0034375)3.73282901
64carboxylic acid catabolic process (GO:0046395)3.72516510
65organic acid catabolic process (GO:0016054)3.72516510
66CENP-A containing nucleosome assembly (GO:0034080)3.72212431
67indolalkylamine metabolic process (GO:0006586)3.72052371
68ribosome assembly (GO:0042255)3.70867370
69ketone body metabolic process (GO:1902224)3.69138918
70IMP metabolic process (GO:0046040)3.67077024
71regulation of fibrinolysis (GO:0051917)3.64329436
72response to mercury ion (GO:0046689)3.61501945
73regulation of cholesterol homeostasis (GO:2000188)3.61112232
74cellular biogenic amine catabolic process (GO:0042402)3.60085089
75amine catabolic process (GO:0009310)3.60085089
76purine nucleobase biosynthetic process (GO:0009113)3.58696346
77cellular glucuronidation (GO:0052695)3.57904704
78sulfur amino acid metabolic process (GO:0000096)3.55719619
79branched-chain amino acid catabolic process (GO:0009083)3.55141348
80regulation of complement activation (GO:0030449)3.53128941
81benzene-containing compound metabolic process (GO:0042537)3.48993368
82heme transport (GO:0015886)3.48690553
83arginine metabolic process (GO:0006525)3.48555087
84protein localization to kinetochore (GO:0034501)3.48177552
85dicarboxylic acid metabolic process (GO:0043648)3.47062253
86tricarboxylic acid metabolic process (GO:0072350)3.45187382
87pantothenate metabolic process (GO:0015939)3.42417359
88ethanol oxidation (GO:0006069)3.42151009
89branched-chain amino acid metabolic process (GO:0009081)3.41932355
90DNA replication checkpoint (GO:0000076)3.41178472
91fatty acid beta-oxidation (GO:0006635)3.37941027
92histone exchange (GO:0043486)3.37413501
93folic acid transport (GO:0015884)3.37315078
94modified amino acid transport (GO:0072337)3.37253969
95one-carbon metabolic process (GO:0006730)3.37219916
96drug metabolic process (GO:0017144)3.36992200
97complement activation, alternative pathway (GO:0006957)3.36520149
98sulfur amino acid biosynthetic process (GO:0000097)3.35888175
99regulation of bile acid biosynthetic process (GO:0070857)3.34338030
100imidazole-containing compound metabolic process (GO:0052803)3.34163297
101acylglycerol homeostasis (GO:0055090)3.32227638
102triglyceride homeostasis (GO:0070328)3.32227638
103metaphase plate congression (GO:0051310)3.30577081
104folic acid-containing compound metabolic process (GO:0006760)3.30487953
105fatty acid oxidation (GO:0019395)3.29845104
106valine metabolic process (GO:0006573)3.26001434
107regulation of helicase activity (GO:0051095)3.25272987
108glutamine family amino acid catabolic process (GO:0009065)3.25220253
109aspartate family amino acid metabolic process (GO:0009066)3.25113567
110protein complex localization (GO:0031503)3.24069569
111lipid oxidation (GO:0034440)3.23899096
112nucleobase biosynthetic process (GO:0046112)3.23440068
113negative regulation of fatty acid biosynthetic process (GO:0045717)3.22411274
114bile acid and bile salt transport (GO:0015721)3.22243429
115establishment of viral latency (GO:0019043)3.21944028
116coenzyme catabolic process (GO:0009109)3.21743412
117nuclear pore complex assembly (GO:0051292)3.15073740
118negative regulation of mitotic sister chromatid separation (GO:2000816)3.14403685
119negative regulation of sister chromatid segregation (GO:0033046)3.14403685
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14403685
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14403685
122negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14403685
123spindle checkpoint (GO:0031577)3.13374855
124mitotic spindle checkpoint (GO:0071174)3.10843031
125negative regulation of chromosome segregation (GO:0051985)3.10829884
126nuclear pore organization (GO:0006999)3.08906397
127DNA double-strand break processing (GO:0000729)3.08808098
128cholesterol biosynthetic process (GO:0006695)3.05050651
129DNA replication-independent nucleosome organization (GO:0034724)3.03329120
130DNA replication-independent nucleosome assembly (GO:0006336)3.03329120
131DNA strand elongation involved in DNA replication (GO:0006271)3.02463127
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.99341501
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97482128
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.97482128
135cellular protein complex localization (GO:0034629)2.94615362
136proteasome assembly (GO:0043248)2.93907313
137anterior/posterior axis specification, embryo (GO:0008595)2.93200288
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89407814
139regulation of mitotic spindle checkpoint (GO:1903504)2.89407814
140DNA strand elongation (GO:0022616)2.87895021
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87402636
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87402636
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86226063
144regulation of cofactor metabolic process (GO:0051193)2.84507691
145regulation of coenzyme metabolic process (GO:0051196)2.84507691
146DNA damage response, detection of DNA damage (GO:0042769)2.83366187
147mitotic sister chromatid segregation (GO:0000070)2.82707159
148ventricular cardiac muscle cell development (GO:0055015)2.82684765
149sterol biosynthetic process (GO:0016126)2.81815262
150nucleotide-sugar biosynthetic process (GO:0009226)2.81501821
151DNA strand renaturation (GO:0000733)2.79965502
152regulation of chromosome segregation (GO:0051983)2.77659158
153mitotic spindle assembly checkpoint (GO:0007094)2.77536828
154double-strand break repair via nonhomologous end joining (GO:0006303)2.76136249
155non-recombinational repair (GO:0000726)2.76136249
156negative regulation of DNA recombination (GO:0045910)2.74725276
157regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73842057
158negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72929125
159tricarboxylic acid cycle (GO:0006099)2.71974451
160regulation of centriole replication (GO:0046599)2.71429305
161regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.70894530
162spindle assembly checkpoint (GO:0071173)2.70504766
163protein localization to chromosome, centromeric region (GO:0071459)2.69862056
164water-soluble vitamin biosynthetic process (GO:0042364)2.69125135
165regulation of sister chromatid segregation (GO:0033045)2.68413182
166regulation of mitotic sister chromatid separation (GO:0010965)2.68413182
167regulation of mitotic sister chromatid segregation (GO:0033047)2.68413182
168DNA ligation (GO:0006266)2.67849369
169female gonad development (GO:0008585)2.66344359
170RNA-dependent DNA replication (GO:0006278)2.66205203
171glutamine metabolic process (GO:0006541)2.65715902
172tRNA aminoacylation for protein translation (GO:0006418)2.65577451
173telomere maintenance via telomerase (GO:0007004)2.64975779
174aldehyde catabolic process (GO:0046185)2.64430961
175plasma lipoprotein particle assembly (GO:0034377)2.64120311
176negative regulation of mitosis (GO:0045839)2.61904577
177sister chromatid segregation (GO:0000819)2.61885985
178cullin deneddylation (GO:0010388)2.61834176
179telomere maintenance via semi-conservative replication (GO:0032201)2.61294200
180mitotic nuclear envelope disassembly (GO:0007077)2.58481695
181amino acid activation (GO:0043038)2.58360932
182tRNA aminoacylation (GO:0043039)2.58360932
183mitotic sister chromatid cohesion (GO:0007064)2.58294091
184pre-miRNA processing (GO:0031054)2.54883781
185DNA replication-dependent nucleosome assembly (GO:0006335)2.53139116
186DNA replication-dependent nucleosome organization (GO:0034723)2.53139116
187anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51895816
188lactate metabolic process (GO:0006089)2.51521223
189very-low-density lipoprotein particle assembly (GO:0034379)2.50483145
190negative regulation of ligase activity (GO:0051352)2.50328444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.21847248
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.74102331
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.10567924
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.14158264
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.06259134
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.77359484
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.34975665
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19478308
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.16173887
10* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.84558591
11E2F7_22180533_ChIP-Seq_HELA_Human2.82292944
12AR_21909140_ChIP-Seq_LNCAP_Human2.53201152
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.43987645
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.42747958
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.41629943
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23711250
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.22673229
18ZNF263_19887448_ChIP-Seq_K562_Human2.14914330
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05381709
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99627791
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98720251
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97088824
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96872701
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89871011
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86699378
26ELK1_19687146_ChIP-ChIP_HELA_Human1.85605568
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83471151
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80405424
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79832993
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76122463
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73943803
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73405839
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.73357395
34NANOG_16153702_ChIP-ChIP_HESCs_Human1.69430120
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69297610
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.69141924
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68886176
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63731641
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62336607
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60655829
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56838501
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55311720
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54033256
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51862579
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51424545
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51257720
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49115130
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47967379
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45484266
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.44688646
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44232870
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43294602
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39969695
54CLOCK_20551151_ChIP-Seq_293T_Human1.39714958
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37092364
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36492688
57SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31212642
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.30573071
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29963100
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.29942617
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29053302
62TTF2_22483619_ChIP-Seq_HELA_Human1.26631365
63FOXP3_21729870_ChIP-Seq_TREG_Human1.22303503
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.21489906
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21307210
66EWS_26573619_Chip-Seq_HEK293_Human1.20587046
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.20124876
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18310070
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17425710
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16044331
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14906515
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14874569
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.13779992
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13173937
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12632019
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12310506
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11635100
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.11076193
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10689362
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09437633
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07788837
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07081818
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06964796
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06183948
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06111078
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05807930
87VDR_23849224_ChIP-Seq_CD4+_Human1.05729680
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05601860
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.03489833
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02444054
91SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01857277
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01246062
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00789623
94* NANOG_16518401_ChIP-PET_MESCs_Mouse1.00070729
95XRN2_22483619_ChIP-Seq_HELA_Human0.99633690
96KDM5A_27292631_Chip-Seq_BREAST_Human0.99529291
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99472255
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99472255
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99472255
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99329568
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98318879
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.97821691
103FUS_26573619_Chip-Seq_HEK293_Human0.97642579
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96694545
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96626794
106RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96366233
107VDR_22108803_ChIP-Seq_LS180_Human0.96138335
108POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95580044
109MYC_18940864_ChIP-ChIP_HL60_Human0.95224500
110TAF15_26573619_Chip-Seq_HEK293_Human0.93908857
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93779958
112ZNF274_21170338_ChIP-Seq_K562_Hela0.92913329
113GABP_19822575_ChIP-Seq_HepG2_Human0.92899821
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92490608
115CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92135992
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91944156
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91646579
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91132242
119P300_19829295_ChIP-Seq_ESCs_Human0.89336868
120NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88915256
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88172230
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88159616
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87792036
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86819172
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.85753560
126ATF3_27146783_Chip-Seq_COLON_Human0.85663400
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.84650431
128DCP1A_22483619_ChIP-Seq_HELA_Human0.83852019
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83808618
130GABP_17652178_ChIP-ChIP_JURKAT_Human0.83253741
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81341562
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81301595
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81099767
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.80728858
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.80675387
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80171280
137ESR2_21235772_ChIP-Seq_MCF-7_Human0.77845691
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.77680386
139E2F1_21310950_ChIP-Seq_MCF-7_Human0.76210962
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75847714
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.75427529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.36632376
2MP0002139_abnormal_hepatobiliary_system6.97930025
3MP0005085_abnormal_gallbladder_physiolo5.18402289
4MP0003806_abnormal_nucleotide_metabolis5.17580152
5MP0005365_abnormal_bile_salt4.90943065
6MP0003941_abnormal_skin_development4.74682244
7MP0008875_abnormal_xenobiotic_pharmacok4.38093421
8MP0005332_abnormal_amino_acid3.67738961
9MP0009840_abnormal_foam_cell3.44224645
10MP0004019_abnormal_vitamin_homeostasis3.24093755
11MP0003195_calcinosis2.87294643
12MP0003252_abnormal_bile_duct2.84458795
13MP0010329_abnormal_lipoprotein_level2.76396788
14MP0008058_abnormal_DNA_repair2.66167766
15MP0008007_abnormal_cellular_replicative2.14100044
16MP0005083_abnormal_biliary_tract2.05563931
17MP0004272_abnormal_basement_membrane2.01108219
18MP0008877_abnormal_DNA_methylation1.98044655
19MP0003122_maternal_imprinting1.89478786
20MP0005451_abnormal_body_composition1.88785851
21MP0009643_abnormal_urine_homeostasis1.85245108
22MP0004043_abnormal_pH_regulation1.84938904
23MP0005319_abnormal_enzyme/_coenzyme1.83955889
24MP0001666_abnormal_nutrient_absorption1.83170984
25MP0000579_abnormal_nail_morphology1.82529969
26MP0003718_maternal_effect1.79794786
27MP0000609_abnormal_liver_physiology1.73775982
28MP0008057_abnormal_DNA_replication1.69452522
29MP0003705_abnormal_hypodermis_morpholog1.69255790
30MP0003937_abnormal_limbs/digits/tail_de1.67818065
31MP0001764_abnormal_homeostasis1.64861519
32MP0002118_abnormal_lipid_homeostasis1.64247424
33MP0003186_abnormal_redox_activity1.61628474
34MP0002138_abnormal_hepatobiliary_system1.51937577
35MP0003693_abnormal_embryo_hatching1.50339463
36MP0002697_abnormal_eye_size1.49883309
37MP0003191_abnormal_cellular_cholesterol1.48134048
38MP0002938_white_spotting1.42386557
39MP0001756_abnormal_urination1.41138343
40MP0003121_genomic_imprinting1.38464708
41MP0004957_abnormal_blastocyst_morpholog1.37017675
42MP0005584_abnormal_enzyme/coenzyme_acti1.36780546
43MP0003111_abnormal_nucleus_morphology1.34581693
44MP0003646_muscle_fatigue1.31345318
45MP0010030_abnormal_orbit_morphology1.30236573
46MP0003119_abnormal_digestive_system1.30152349
47MP0001188_hyperpigmentation1.29253110
48MP0002085_abnormal_embryonic_tissue1.28830064
49MP0001177_atelectasis1.28117350
50MP0001286_abnormal_eye_development1.25325957
51MP0005636_abnormal_mineral_homeostasis1.24193356
52MP0006036_abnormal_mitochondrial_physio1.23531839
53MP0000350_abnormal_cell_proliferation1.23197031
54MP0002090_abnormal_vision1.19974476
55MP0009703_decreased_birth_body1.18885458
56MP0002233_abnormal_nose_morphology1.16736229
57MP0006035_abnormal_mitochondrial_morpho1.15739926
58MP0006292_abnormal_olfactory_placode1.12619672
59MP0001529_abnormal_vocalization1.12555961
60MP0000537_abnormal_urethra_morphology1.08197532
61MP0000598_abnormal_liver_morphology1.07970082
62MP0003136_yellow_coat_color1.07539743
63MP0005395_other_phenotype1.06418555
64MP0003868_abnormal_feces_composition1.04699156
65MP0009697_abnormal_copulation1.04694179
66MP0005670_abnormal_white_adipose1.03101215
67MP0004133_heterotaxia1.02154288
68MP0003315_abnormal_perineum_morphology1.00413695
69MP0002136_abnormal_kidney_physiology0.99075258
70MP0004215_abnormal_myocardial_fiber0.99010097
71MP0000647_abnormal_sebaceous_gland0.96570766
72MP0005266_abnormal_metabolism0.95157165
73MP0001730_embryonic_growth_arrest0.94622993
74MP0001299_abnormal_eye_distance/0.94333380
75MP0009672_abnormal_birth_weight0.93525158
76MP0003329_amyloid_beta_deposits0.91071898
77MP0000566_synostosis0.91046976
78MP0000762_abnormal_tongue_morphology0.90381033
79MP0010234_abnormal_vibrissa_follicle0.89578806
80MP0002111_abnormal_tail_morphology0.89076745
81MP0001661_extended_life_span0.88386711
82MP0009053_abnormal_anal_canal0.88374722
83MP0003950_abnormal_plasma_membrane0.88238456
84MP0001984_abnormal_olfaction0.86456276
85MP0003878_abnormal_ear_physiology0.84974563
86MP0005377_hearing/vestibular/ear_phenot0.84974563
87MP0001915_intracranial_hemorrhage0.82921737
88MP0001765_abnormal_ion_homeostasis0.82824573
89MP0008260_abnormal_autophagy0.80350734
90MP0003011_delayed_dark_adaptation0.78857330
91MP0005666_abnormal_adipose_tissue0.78817389
92MP0010307_abnormal_tumor_latency0.78090167
93MP0000604_amyloidosis0.77943941
94MP0004264_abnormal_extraembryonic_tissu0.77681988
95MP0010094_abnormal_chromosome_stability0.77577906
96MP0003755_abnormal_palate_morphology0.77328382
97MP0002269_muscular_atrophy0.77124189
98MP0005376_homeostasis/metabolism_phenot0.75912330
99MP0006072_abnormal_retinal_apoptosis0.71894623
100MP0002092_abnormal_eye_morphology0.71443590
101MP0003077_abnormal_cell_cycle0.70964495
102MP0001672_abnormal_embryogenesis/_devel0.70348450
103MP0005380_embryogenesis_phenotype0.70348450
104MP0003221_abnormal_cardiomyocyte_apopto0.69346984
105MP0005501_abnormal_skin_physiology0.68987356
106MP0003786_premature_aging0.68965860
107MP0002751_abnormal_autonomic_nervous0.68148601
108MP0002102_abnormal_ear_morphology0.67162159
109MP0002796_impaired_skin_barrier0.66592802
110MP0005647_abnormal_sex_gland0.66300345
111MP0009642_abnormal_blood_homeostasis0.65244087
112MP0004885_abnormal_endolymph0.63930843
113MP0003861_abnormal_nervous_system0.63316570
114MP0002088_abnormal_embryonic_growth/wei0.63068649
115MP0005408_hypopigmentation0.62561754
116MP0003566_abnormal_cell_adhesion0.62411239
117MP0003984_embryonic_growth_retardation0.61898104
118MP0005499_abnormal_olfactory_system0.61239525
119MP0005394_taste/olfaction_phenotype0.61239525
120MP0008789_abnormal_olfactory_epithelium0.60750440
121MP0002736_abnormal_nociception_after0.60208529
122MP0001929_abnormal_gametogenesis0.59972978
123MP0005058_abnormal_lysosome_morphology0.59911551
124MP0002086_abnormal_extraembryonic_tissu0.57927086
125MP0000358_abnormal_cell_content/0.56224538
126MP0004084_abnormal_cardiac_muscle0.55857129
127MP0003567_abnormal_fetal_cardiomyocyte0.54817812
128MP0009763_increased_sensitivity_to0.53442754
129MP0002254_reproductive_system_inflammat0.53116412
130MP0000747_muscle_weakness0.52654207
131MP0001697_abnormal_embryo_size0.52605218
132MP0005330_cardiomyopathy0.52492518
133MP0003656_abnormal_erythrocyte_physiolo0.51758652
134MP0002080_prenatal_lethality0.50845316
135MP0002971_abnormal_brown_adipose0.50254726
136MP0002078_abnormal_glucose_homeostasis0.49800561
137MP0003123_paternal_imprinting0.46902896
138MP0010352_gastrointestinal_tract_polyps0.46681944
139MP0003699_abnormal_female_reproductive0.46282802
140MP0005084_abnormal_gallbladder_morpholo0.46276402
141MP0002168_other_aberrant_phenotype0.44323049
142MP0002653_abnormal_ependyma_morphology0.43953062
143MP0009765_abnormal_xenobiotic_induced0.43374474
144MP0002084_abnormal_developmental_patter0.42640323
145MP0003890_abnormal_embryonic-extraembry0.42403453
146MP0005535_abnormal_body_temperature0.41641491
147MP0005187_abnormal_penis_morphology0.41068707
148MP0008932_abnormal_embryonic_tissue0.39289147
149MP0004130_abnormal_muscle_cell0.38446802
150MP0001293_anophthalmia0.37613046
151MP0003638_abnormal_response/metabolism_0.37343437
152MP0004197_abnormal_fetal_growth/weight/0.37307629

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.02566167
2Hyperglycinemia (HP:0002154)5.72426611
3Abnormality of serine family amino acid metabolism (HP:0010894)5.52782647
4Abnormality of glycine metabolism (HP:0010895)5.52782647
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.46148893
6Intrahepatic cholestasis (HP:0001406)5.42916272
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.30889820
8Gout (HP:0001997)5.24874527
9Xanthomatosis (HP:0000991)5.08329185
10Deep venous thrombosis (HP:0002625)4.86810836
11Hyperammonemia (HP:0001987)4.78645545
12Hypobetalipoproteinemia (HP:0003563)4.74453095
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.67177136
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.26135617
15Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22336645
16Ketosis (HP:0001946)4.15956870
17Hyperlipoproteinemia (HP:0010980)4.10869518
18Abnormality of serum amino acid levels (HP:0003112)3.90910076
19Hypolipoproteinemia (HP:0010981)3.87109303
20Abnormality of the labia minora (HP:0012880)3.84349187
21Abnormality of pyrimidine metabolism (HP:0004353)3.78398482
22Proximal tubulopathy (HP:0000114)3.72690774
23Abnormality of fatty-acid metabolism (HP:0004359)3.64714196
24Prolonged partial thromboplastin time (HP:0003645)3.64080377
25Abnormality of nucleobase metabolism (HP:0010932)3.63346590
26Increased purine levels (HP:0004368)3.60443665
27Hyperuricemia (HP:0002149)3.60443665
28Delayed CNS myelination (HP:0002188)3.59574983
29Abnormality of methionine metabolism (HP:0010901)3.59316463
30Hypoalphalipoproteinemia (HP:0003233)3.56595489
31Abnormality of purine metabolism (HP:0004352)3.55820644
32Hypoglycemic coma (HP:0001325)3.41724953
33Colon cancer (HP:0003003)3.39627297
34Ketoacidosis (HP:0001993)3.35574531
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30820594
36Dicarboxylic aciduria (HP:0003215)3.21961578
37Abnormality of dicarboxylic acid metabolism (HP:0010995)3.21961578
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16344015
39Lethargy (HP:0001254)3.11598497
40Spastic diplegia (HP:0001264)3.04792371
41Chromsome breakage (HP:0040012)3.03812145
42Generalized aminoaciduria (HP:0002909)3.00026763
43Nephroblastoma (Wilms tumor) (HP:0002667)2.91281353
44Ependymoma (HP:0002888)2.85356370
45Metabolic acidosis (HP:0001942)2.82698042
46Complement deficiency (HP:0004431)2.81366598
47Epidermoid cyst (HP:0200040)2.81104012
48Fat malabsorption (HP:0002630)2.79727956
49Irritability (HP:0000737)2.78201752
50Alkalosis (HP:0001948)2.76680179
51Embryonal renal neoplasm (HP:0011794)2.75850699
52Meckel diverticulum (HP:0002245)2.72424927
53Malnutrition (HP:0004395)2.71606836
54Abnormal lung lobation (HP:0002101)2.66625045
55Hypoglycemic seizures (HP:0002173)2.65798695
56Rhabdomyosarcoma (HP:0002859)2.64914654
57Birth length less than 3rd percentile (HP:0003561)2.59337059
58Glycosuria (HP:0003076)2.58138642
59Abnormality of urine glucose concentration (HP:0011016)2.58138642
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56603599
61Cholecystitis (HP:0001082)2.53536166
62Cortical dysplasia (HP:0002539)2.53292667
63Abnormality of the ileum (HP:0001549)2.52656405
64Increased circulating renin level (HP:0000848)2.51646880
65Hepatocellular carcinoma (HP:0001402)2.51179906
66Vascular calcification (HP:0004934)2.50648278
67Megaloblastic anemia (HP:0001889)2.48756484
68Abnormality of the common coagulation pathway (HP:0010990)2.45312426
69Joint hemorrhage (HP:0005261)2.44473209
70Pancreatic islet-cell hyperplasia (HP:0004510)2.44302279
71Hypokalemic alkalosis (HP:0001949)2.39268757
72Hepatoblastoma (HP:0002884)2.39090682
73Exercise-induced muscle cramps (HP:0003710)2.35757468
74Abnormal cartilage morphology (HP:0002763)2.34698035
75Confusion (HP:0001289)2.34465664
76Abnormality of chromosome stability (HP:0003220)2.33840680
77Nausea (HP:0002018)2.33735544
78Hydroxyprolinuria (HP:0003080)2.32691791
79Abnormality of proline metabolism (HP:0010907)2.32691791
80Vomiting (HP:0002013)2.32128839
81Neonatal onset (HP:0003623)2.31435190
82Neoplasm of the adrenal gland (HP:0100631)2.30631167
83Hyperbilirubinemia (HP:0002904)2.27478365
84Medulloblastoma (HP:0002885)2.24711384
85Rickets (HP:0002748)2.21958677
86Hyperactive renin-angiotensin system (HP:0000841)2.21223156
87Hypercholesterolemia (HP:0003124)2.20336240
88Cerebral edema (HP:0002181)2.19669548
89Bifid tongue (HP:0010297)2.19260227
90Abnormality of the preputium (HP:0100587)2.17650861
91Abnormality of the intrinsic pathway (HP:0010989)2.16803998
92Hyperinsulinemic hypoglycemia (HP:0000825)2.16495630
93Absent radius (HP:0003974)2.15515893
94Cardiovascular calcification (HP:0011915)2.15496501
95Choanal stenosis (HP:0000452)2.14339288
96Abnormal urine output (HP:0012590)2.12255243
97Spontaneous abortion (HP:0005268)2.10757759
98Metabolic alkalosis (HP:0200114)2.09444783
99Polyuria (HP:0000103)2.08716373
100Glioma (HP:0009733)2.08528568
101Multiple enchondromatosis (HP:0005701)2.07519953
102Stenosis of the external auditory canal (HP:0000402)2.06676599
103Status epilepticus (HP:0002133)2.04363693
104Aplasia involving forearm bones (HP:0009822)2.02010223
105Absent forearm bone (HP:0003953)2.02010223
106Metaphyseal cupping (HP:0003021)2.01834599
107Pterygium (HP:0001059)2.01346460
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.01259609
109Reduced antithrombin III activity (HP:0001976)2.01215203
110Conjugated hyperbilirubinemia (HP:0002908)1.99438133
111Agnosia (HP:0010524)1.98537531
112Abnormality of the astrocytes (HP:0100707)1.97809483
113Astrocytoma (HP:0009592)1.97809483
114Steatorrhea (HP:0002570)1.97655293
115Postnatal microcephaly (HP:0005484)1.95923777
116Global brain atrophy (HP:0002283)1.95896372
117Hyperglycemia (HP:0003074)1.95792473
118Abnormal enzyme/coenzyme activity (HP:0012379)1.95650467
119Nephrolithiasis (HP:0000787)1.95069952
120Methylmalonic aciduria (HP:0012120)1.94445291
121Abnormality of complement system (HP:0005339)1.92639606
122Enlarged kidneys (HP:0000105)1.91385559
123Supernumerary spleens (HP:0009799)1.89920721
124Abnormality of glycolysis (HP:0004366)1.89723153
125Increased serum pyruvate (HP:0003542)1.89723153
126Abnormality of alanine metabolism (HP:0010916)1.89194268
127Hyperalaninemia (HP:0003348)1.89194268
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89194268
129Increased nuchal translucency (HP:0010880)1.88812842
130Abnormality of renal excretion (HP:0011036)1.88794016
131Symptomatic seizures (HP:0011145)1.88319056
132Skin nodule (HP:0200036)1.88080110
133Late onset (HP:0003584)1.87727748
134Bilateral microphthalmos (HP:0007633)1.86931027
135Absent eyebrow (HP:0002223)1.86572115
136Sensorimotor neuropathy (HP:0007141)1.86143087
137Right ventricular cardiomyopathy (HP:0011663)1.85922635
138Back pain (HP:0003418)1.85455477
139Abnormality of chloride homeostasis (HP:0011422)1.85204956
140Tetraplegia (HP:0002445)1.84840223
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.84517869
142Myelomeningocele (HP:0002475)1.83821404
143Abnormality of vitamin metabolism (HP:0100508)1.79733648
144Esophageal varix (HP:0002040)1.79273973
145Abnormality of the duodenum (HP:0002246)1.79078579
146Small intestinal stenosis (HP:0012848)1.78573510
147Duodenal stenosis (HP:0100867)1.78573510
148Abnormality of alkaline phosphatase activity (HP:0004379)1.77999611
149Hyperphosphaturia (HP:0003109)1.77534810
150Hypomagnesemia (HP:0002917)1.77168717
151Spastic paraparesis (HP:0002313)1.76183776
152Abnormal gallbladder physiology (HP:0012438)1.74026673
153Horseshoe kidney (HP:0000085)1.74002959
154Biliary tract neoplasm (HP:0100574)1.72401983
155Gonadotropin excess (HP:0000837)1.72135363
156Embryonal neoplasm (HP:0002898)1.71297269
157Hypoplastic female external genitalia (HP:0012815)1.69570386
158Absent eyelashes (HP:0000561)1.69435455
159Septo-optic dysplasia (HP:0100842)1.69349967
160Acute encephalopathy (HP:0006846)1.68585558
161Methylmalonic acidemia (HP:0002912)1.67210006
162Hypoplastic pelvis (HP:0008839)1.65020420
163Facial cleft (HP:0002006)1.64553836
164Ovarian neoplasm (HP:0100615)1.64407664
165Uterine neoplasm (HP:0010784)1.63267594
166Anal stenosis (HP:0002025)1.62966108
167Neoplasm of the colon (HP:0100273)1.62519131
168Breast aplasia (HP:0100783)1.61352250
169Abnormality of the parathyroid morphology (HP:0011766)1.60917307
170Type I transferrin isoform profile (HP:0003642)1.60240923
171Aplasia/Hypoplasia of the breasts (HP:0010311)1.56351780
172Labial hypoplasia (HP:0000066)1.54677139
173Gastrointestinal carcinoma (HP:0002672)1.54553834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.85888347
2BCKDK4.76044911
3WEE13.78459957
4PBK3.63351234
5EPHA23.28413725
6WNK33.15829433
7STK38L2.94229292
8TNIK2.93869092
9MKNK22.93180541
10TRIM282.62620078
11PDK42.55283751
12PDK32.55283751
13MKNK12.54774818
14BUB12.53830553
15TTK2.31587202
16VRK22.06589513
17WNK42.06325387
18PNCK2.03069490
19MST41.96814717
20AKT31.93983937
21EIF2AK11.92966182
22PKN21.84309636
23LATS21.77728579
24OXSR11.75419373
25FGFR41.73081193
26TSSK61.70954413
27PDK21.70887550
28TAF11.69315339
29NEK21.67277687
30STK381.51450052
31LATS11.45406167
32PINK11.41388485
33TRIB31.39159378
34BCR1.37977112
35NUAK11.35701147
36BMPR1B1.31632809
37CDK41.25349816
38ERBB41.19633214
39PLK11.17487420
40SIK11.16209945
41BRSK21.09632060
42TAOK21.08546282
43MST1R1.03374212
44ABL21.02850625
45MAP3K81.00789888
46VRK11.00124915
47PLK30.97365963
48MAP2K40.96179238
49CDC70.96124716
50EPHA40.94966120
51MAP3K90.94350167
52STK390.92955691
53FLT30.92930258
54ACVR1B0.92467311
55STK240.92029798
56ARAF0.90987543
57EIF2AK20.90412264
58MAPK110.88062349
59PLK40.85083394
60MAP3K30.85079952
61AURKA0.84494791
62BRAF0.84453260
63ALK0.84034009
64NME20.84001607
65ATR0.80767261
66MET0.80481069
67STK160.80261540
68PLK20.76472688
69CASK0.75894477
70CSNK1G10.75493052
71KSR20.73181046
72STK30.72997071
73PRKAA10.72353404
74KSR10.71548174
75ATM0.69988433
76MTOR0.69928000
77MAP3K50.69001368
78AURKB0.68027221
79BRSK10.67494476
80PRKCI0.66603374
81CSNK1E0.66286935
82CHEK20.66017729
83EIF2AK30.64836626
84SGK30.62976455
85RPS6KB20.62523823
86TGFBR10.61321754
87MAP3K110.60965409
88CDK120.59936361
89STK40.59523879
90PAK40.57064407
91FGFR20.56949089
92SGK4940.56298767
93SGK2230.56298767
94NME10.53475592
95BRD40.53236403
96SGK20.52098650
97PRKCG0.51143141
98SRPK10.51036566
99DYRK20.49714578
100CSNK1G20.48940438
101CDK60.48825219
102ERBB30.48707206
103CSNK1A1L0.48596317
104AKT20.48316050
105GRK60.47816204
106CHEK10.47637935
107RIPK10.45980905
108CDK20.45279120
109RPS6KA40.45013378
110ERN10.44984750
111DYRK30.44652068
112MAP2K30.44260286
113CSNK2A10.44080333
114PASK0.43483822
115FGFR10.42893405
116MELK0.42436877
117PRKDC0.42066879
118FER0.41348994
119NLK0.41322363
120CDK10.41275458
121CSNK1G30.41251447
122DMPK0.41095574
123CDK70.39920113
124GRK10.37505328
125YES10.36746533
126MINK10.36527275
127NEK90.36501821
128TESK20.35692520
129PRKAA20.34832912
130ERBB20.34670181
131GSK3A0.34330278
132DAPK10.34014889
133PRKACG0.33405452
134CSNK2A20.33284597
135CDK190.33066724
136RAF10.32376067
137PRKCZ0.31783253
138PAK60.31502100
139SMG10.31478569
140PAK20.31380975
141PTK20.30755834
142ZAK0.30068031
143CDK180.30066210
144SCYL20.29759481
145PDPK10.28509588
146MAP3K70.28420592
147PRKCE0.27979366
148CDK90.27053655

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38056114
2Nitrogen metabolism_Homo sapiens_hsa009103.33139785
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.24267190
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.22809195
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15443716
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.86724582
7Arginine biosynthesis_Homo sapiens_hsa002202.80088128
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74410014
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54572330
10Butanoate metabolism_Homo sapiens_hsa006502.46668367
11Fatty acid degradation_Homo sapiens_hsa000712.36068432
12Tryptophan metabolism_Homo sapiens_hsa003802.28642182
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24447611
14Propanoate metabolism_Homo sapiens_hsa006402.21750571
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.12158656
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.07050361
17Non-homologous end-joining_Homo sapiens_hsa034501.99226288
18Biosynthesis of amino acids_Homo sapiens_hsa012301.95274815
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94816966
20Peroxisome_Homo sapiens_hsa041461.91307266
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91256845
22Carbon metabolism_Homo sapiens_hsa012001.89983218
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79527075
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.78066029
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72679132
26beta-Alanine metabolism_Homo sapiens_hsa004101.72641463
27Fatty acid metabolism_Homo sapiens_hsa012121.72492913
28Selenocompound metabolism_Homo sapiens_hsa004501.68680183
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67109680
30Pyruvate metabolism_Homo sapiens_hsa006201.66111061
31Protein export_Homo sapiens_hsa030601.57701370
32Vitamin B6 metabolism_Homo sapiens_hsa007501.57671303
33Complement and coagulation cascades_Homo sapiens_hsa046101.57655340
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52692107
35Folate biosynthesis_Homo sapiens_hsa007901.48357029
36PPAR signaling pathway_Homo sapiens_hsa033201.48075521
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46034452
38One carbon pool by folate_Homo sapiens_hsa006701.44283968
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41622662
40Bile secretion_Homo sapiens_hsa049761.40390085
41Homologous recombination_Homo sapiens_hsa034401.39006732
42Chemical carcinogenesis_Homo sapiens_hsa052041.36795040
43Pentose phosphate pathway_Homo sapiens_hsa000301.35536911
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31814530
45Arginine and proline metabolism_Homo sapiens_hsa003301.31060153
46Base excision repair_Homo sapiens_hsa034101.30936039
47Histidine metabolism_Homo sapiens_hsa003401.29714462
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.28269802
49Phenylalanine metabolism_Homo sapiens_hsa003601.25467065
50Retinol metabolism_Homo sapiens_hsa008301.24432837
51RNA degradation_Homo sapiens_hsa030181.21448376
52Fructose and mannose metabolism_Homo sapiens_hsa000511.20392771
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20277966
54Vitamin digestion and absorption_Homo sapiens_hsa049771.16344988
55Spliceosome_Homo sapiens_hsa030401.14498624
56Starch and sucrose metabolism_Homo sapiens_hsa005001.11029857
57Basal transcription factors_Homo sapiens_hsa030221.08731808
58Glutathione metabolism_Homo sapiens_hsa004801.06721038
59Fanconi anemia pathway_Homo sapiens_hsa034600.99557894
60Tyrosine metabolism_Homo sapiens_hsa003500.97832675
61Caffeine metabolism_Homo sapiens_hsa002320.93190704
62Lysine degradation_Homo sapiens_hsa003100.91126148
63Sulfur relay system_Homo sapiens_hsa041220.89881213
64mRNA surveillance pathway_Homo sapiens_hsa030150.84659228
65Glycerolipid metabolism_Homo sapiens_hsa005610.80864901
66Sulfur metabolism_Homo sapiens_hsa009200.78211016
67Fatty acid elongation_Homo sapiens_hsa000620.77019451
68Fat digestion and absorption_Homo sapiens_hsa049750.76850085
69Proteasome_Homo sapiens_hsa030500.73341652
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72835155
71Staphylococcus aureus infection_Homo sapiens_hsa051500.63198798
72Oocyte meiosis_Homo sapiens_hsa041140.62440940
73Steroid biosynthesis_Homo sapiens_hsa001000.58108483
74* Metabolic pathways_Homo sapiens_hsa011000.57649079
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57058890
76ABC transporters_Homo sapiens_hsa020100.56516151
77Galactose metabolism_Homo sapiens_hsa000520.55813049
78p53 signaling pathway_Homo sapiens_hsa041150.53494075
79Parkinsons disease_Homo sapiens_hsa050120.53129060
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52535497
81Adherens junction_Homo sapiens_hsa045200.51985482
82Regulation of autophagy_Homo sapiens_hsa041400.51130008
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50886967
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47794031
85Hippo signaling pathway_Homo sapiens_hsa043900.47652481
86RNA transport_Homo sapiens_hsa030130.47439614
87Tight junction_Homo sapiens_hsa045300.45685296
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44385549
89Huntingtons disease_Homo sapiens_hsa050160.42872696
90TGF-beta signaling pathway_Homo sapiens_hsa043500.42556375
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41870447
92N-Glycan biosynthesis_Homo sapiens_hsa005100.41554627
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40924171
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.39699003
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39361778
96Oxidative phosphorylation_Homo sapiens_hsa001900.38637884
97Pyrimidine metabolism_Homo sapiens_hsa002400.37968929
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.37116837
99Ribosome_Homo sapiens_hsa030100.35654797
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33275298
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30748210
102Thyroid cancer_Homo sapiens_hsa052160.28571940
103RNA polymerase_Homo sapiens_hsa030200.24652881
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23335942
105Fatty acid biosynthesis_Homo sapiens_hsa000610.20600449
106Mismatch repair_Homo sapiens_hsa034300.20283617
107DNA replication_Homo sapiens_hsa030300.18400850
108AMPK signaling pathway_Homo sapiens_hsa041520.13246059
109Glucagon signaling pathway_Homo sapiens_hsa049220.12688421
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10356574
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09028039
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.08842999
113Insulin resistance_Homo sapiens_hsa049310.06823959
114Mineral absorption_Homo sapiens_hsa049780.05549584
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.04209385
116Prion diseases_Homo sapiens_hsa050200.01503964
117Renin-angiotensin system_Homo sapiens_hsa046140.01450055
118Nucleotide excision repair_Homo sapiens_hsa034200.01097513
119Insulin signaling pathway_Homo sapiens_hsa04910-0.0715803
120mTOR signaling pathway_Homo sapiens_hsa04150-0.0632394
121* Purine metabolism_Homo sapiens_hsa00230-0.0574594
122Cell cycle_Homo sapiens_hsa04110-0.0512265
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0380527
124Collecting duct acid secretion_Homo sapiens_hsa04966-0.0289588
125Linoleic acid metabolism_Homo sapiens_hsa00591-0.0257863

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