ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline biosynthetic process (GO:0006561)	4.80877545
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.74997788
3	L-phenylalanine metabolic process (GO:0006558)	4.74997788
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.31264424
5	L-phenylalanine catabolic process (GO:0006559)	4.31264424
6	proteasome assembly (GO:0043248)	4.26176172
7	proline metabolic process (GO:0006560)	4.19036958
8	very-low-density lipoprotein particle assembly (GO:0034379)	4.12776880
9	negative regulation of myeloid cell apoptotic process (GO:0033033)	3.78751103
10	ribosome assembly (GO:0042255)	3.64815442
11	peptidyl-glutamic acid carboxylation (GO:0017187)	3.58242408
12	protein carboxylation (GO:0018214)	3.58242408
13	intestinal cholesterol absorption (GO:0030299)	3.48193018
14	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.47004601
15	transcription from mitochondrial promoter (GO:0006390)	3.46788280
16	innate immune response in mucosa (GO:0002227)	3.34481517
17	regulation of mitochondrial translation (GO:0070129)	3.28742644
18	negative regulation of fibrinolysis (GO:0051918)	3.25292699
19	plasma lipoprotein particle assembly (GO:0034377)	3.21758782
20	RNA localization (GO:0006403)	3.18857723
21	establishment of viral latency (GO:0019043)	3.15169995
22	regulation of protein activation cascade (GO:2000257)	3.14780368
23	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.12596347
24	regulation of bile acid biosynthetic process (GO:0070857)	3.10218983
25	regulation of fibrinolysis (GO:0051917)	3.09051671
26	glutamine family amino acid biosynthetic process (GO:0009084)	3.08667915
27	cholesterol efflux (GO:0033344)	3.06884131
28	maturation of 5.8S rRNA (GO:0000460)	3.06638337
29	4-hydroxyproline metabolic process (GO:0019471)	3.06531615
30	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	3.06315645
31	regulation of cholesterol homeostasis (GO:2000188)	3.03707738
32	glucose 6-phosphate metabolic process (GO:0051156)	3.03687463
33	protein maturation by protein folding (GO:0022417)	2.99543541
34	glycolytic process (GO:0006096)	2.99501917
35	dicarboxylic acid biosynthetic process (GO:0043650)	2.98838549
36	establishment of integrated proviral latency (GO:0075713)	2.96200617
37	mucosal immune response (GO:0002385)	2.94168253
38	cellular modified amino acid catabolic process (GO:0042219)	2.93549709
39	regulation of complement activation (GO:0030449)	2.92371754
40	aromatic amino acid family catabolic process (GO:0009074)	2.92205660
41	gluconeogenesis (GO:0006094)	2.88306812
42	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.87778081
43	hexose biosynthetic process (GO:0019319)	2.87201234
44	blood coagulation, intrinsic pathway (GO:0007597)	2.84121869
45	GDP-mannose metabolic process (GO:0019673)	2.83070123
46	triglyceride homeostasis (GO:0070328)	2.81680276
47	acylglycerol homeostasis (GO:0055090)	2.81680276
48	COPII vesicle coating (GO:0048208)	2.81539069
49	ribosome biogenesis (GO:0042254)	2.80183158
50	tetrahydrofolate metabolic process (GO:0046653)	2.79870494
51	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	2.79703927
52	regulation of prostaglandin secretion (GO:0032306)	2.77921101
53	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.75912934
54	deoxyribonucleotide biosynthetic process (GO:0009263)	2.75118807
55	branched-chain amino acid catabolic process (GO:0009083)	2.74621405
56	organ or tissue specific immune response (GO:0002251)	2.71026835
57	protein-lipid complex assembly (GO:0065005)	2.70226975
58	monosaccharide biosynthetic process (GO:0046364)	2.69455648
59	rRNA modification (GO:0000154)	2.68765172
60	positive regulation of humoral immune response (GO:0002922)	2.66571990
61	DNA catabolic process, exonucleolytic (GO:0000738)	2.65269612
62	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.63714291
63	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.61867555
64	xenobiotic catabolic process (GO:0042178)	2.61590511
65	binding of sperm to zona pellucida (GO:0007339)	2.61209839
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.61008140
67	negative regulation of sterol transport (GO:0032372)	2.59922114
68	negative regulation of cholesterol transport (GO:0032375)	2.59922114
69	rRNA methylation (GO:0031167)	2.59095064
70	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.58064319
71	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.56609400
72	deoxyribose phosphate biosynthetic process (GO:0046385)	2.56609400
73	chaperone-mediated protein complex assembly (GO:0051131)	2.55890483
74	mitochondrial RNA metabolic process (GO:0000959)	2.54793398
75	pyruvate metabolic process (GO:0006090)	2.53224665
76	glutamate metabolic process (GO:0006536)	2.52822970
77	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.51252244
78	pteridine-containing compound biosynthetic process (GO:0042559)	2.50728701
79	cysteine metabolic process (GO:0006534)	2.49962863
80	L-ascorbic acid metabolic process (GO:0019852)	2.49538045
81	chromatin assembly (GO:0031497)	2.49131758
82	regulation of cellular amino acid metabolic process (GO:0006521)	2.47710198
83	formation of translation preinitiation complex (GO:0001731)	2.47447399
84	positive regulation of cellular amine metabolic process (GO:0033240)	2.46409459
85	ribosomal large subunit biogenesis (GO:0042273)	2.46194674
86	daunorubicin metabolic process (GO:0044597)	2.46193768
87	polyketide metabolic process (GO:0030638)	2.46193768
88	doxorubicin metabolic process (GO:0044598)	2.46193768
89	spliceosomal snRNP assembly (GO:0000387)	2.46056831
90	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.44815616
91	tricarboxylic acid cycle (GO:0006099)	2.44126877
92	DNA replication-dependent nucleosome organization (GO:0034723)	2.42873990
93	DNA replication-dependent nucleosome assembly (GO:0006335)	2.42873990
94	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.42477068
95	pseudouridine synthesis (GO:0001522)	2.42098145
96	rRNA processing (GO:0006364)	2.41613488
97	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.41385107
98	glycine metabolic process (GO:0006544)	2.40543582
99	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.39242484
100	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.38237214

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.04809044
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.83432671
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.01726162
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.34921811
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.23623052
6	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.98992782
7	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.94700729
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86395914
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81633132
10	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.72978427
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.64055375
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.63322471
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.62618704
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.55043435
15	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.53674634
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.51881045
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49863244
18	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.49230137
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43395194
20	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.38639444
21	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.38293370
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.37354108
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30009417
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.19468477
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.09436470
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.08277173
27	DCP1A_22483619_ChIP-Seq_HELA_Human	2.05442236
28	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.03493484
29	VDR_23849224_ChIP-Seq_CD4+_Human	2.02523247
30	AR_21909140_ChIP-Seq_LNCAP_Human	1.99464688
31	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.92751957
32	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.91872089
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.90393628
34	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.88526706
35	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.88129700
36	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.86620875
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85694308
38	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.84960479
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.83523994
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81411813
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80655312
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.75921225
43	GABP_19822575_ChIP-Seq_HepG2_Human	1.75253865
44	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.75231701
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66757966
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63147521
47	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.62520719
48	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.62400904
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.61801082
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.59939706
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59050642
52	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.55463615
53	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.55029106
54	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.54955697
55	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.53559366
56	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.52760387
57	XRN2_22483619_ChIP-Seq_HELA_Human	1.50005126
58	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.46412252
59	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.46154469
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45293221
61	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.43431022
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40978586
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.37090844
64	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.36635498
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35999720
66	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.35346130
67	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.32400849
68	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.31195086
69	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.29286068
70	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.29111950
71	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.22311026
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.21861589
73	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14582009
74	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.14487525
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13935844
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13319760
77	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.11683308
78	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10778651
79	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.09616810
80	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05232598
81	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.04662336
82	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04028486
83	TFEB_21752829_ChIP-Seq_HELA_Human	1.03424815
84	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.03115149
85	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.02216511
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.01322153
87	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01167273
88	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.01153562
89	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.01124884
90	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.99441977
91	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.99171210
92	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.98587323
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.97847181
94	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.95178929
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94590414
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.92555680
97	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.91620007
98	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.91381345
99	MYC_18940864_ChIP-ChIP_HL60_Human	0.90214747
100	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.89437696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	6.63286782
2	MP0005645_abnormal_hypothalamus_physiol	3.85713257
3	MP0005360_urolithiasis	3.56315543
4	MP0003806_abnormal_nucleotide_metabolis	3.49820141
5	MP0002138_abnormal_hepatobiliary_system	3.03935095
6	MP0003693_abnormal_embryo_hatching	2.92112291
7	MP0009697_abnormal_copulation	2.85868261
8	MP0005365_abnormal_bile_salt	2.80525392
9	MP0005085_abnormal_gallbladder_physiolo	2.74076299
10	MP0008875_abnormal_xenobiotic_pharmacok	2.67610593
11	MP0003868_abnormal_feces_composition	2.66800900
12	MP0004957_abnormal_blastocyst_morpholog	2.63639217
13	MP0003195_calcinosis	2.61512713
14	MP0008058_abnormal_DNA_repair	2.61339467
15	MP0005451_abnormal_body_composition	2.60929601
16	MP0010094_abnormal_chromosome_stability	2.48268068
17	MP0001666_abnormal_nutrient_absorption	2.27490335
18	MP0003718_maternal_effect	2.17701482
19	MP0003186_abnormal_redox_activity	2.09186428
20	MP0003111_abnormal_nucleus_morphology	2.06883449
21	MP0003950_abnormal_plasma_membrane	2.04986838
22	MP0008057_abnormal_DNA_replication	2.01492519
23	MP0001764_abnormal_homeostasis	1.98601319
24	MP0003077_abnormal_cell_cycle	1.98056992
25	MP0003941_abnormal_skin_development	1.85233829
26	MP0006035_abnormal_mitochondrial_morpho	1.75030673
27	MP0001727_abnormal_embryo_implantation	1.69122028
28	MP0005084_abnormal_gallbladder_morpholo	1.68720678
29	MP0005332_abnormal_amino_acid	1.67898329
30	MP0001881_abnormal_mammary_gland	1.63291510
31	MP0010329_abnormal_lipoprotein_level	1.57498246
32	MP0003252_abnormal_bile_duct	1.56168223
33	MP0000685_abnormal_immune_system	1.51496411
34	MP0000358_abnormal_cell_content/	1.48992782
35	MP0001661_extended_life_span	1.44475052
36	MP0000609_abnormal_liver_physiology	1.36247729
37	MP0008007_abnormal_cellular_replicative	1.32834170
38	MP0002132_abnormal_respiratory_system	1.32087181
39	MP0008932_abnormal_embryonic_tissue	1.30601633
40	MP0003183_abnormal_peptide_metabolism	1.25898536
41	MP0009046_muscle_twitch	1.10857867
42	MP0004233_abnormal_muscle_weight	1.10748429
43	MP0010307_abnormal_tumor_latency	1.10268785
44	MP0001730_embryonic_growth_arrest	1.09301138
45	MP0004019_abnormal_vitamin_homeostasis	1.05166778
46	MP0006036_abnormal_mitochondrial_physio	1.03848774
47	MP0004272_abnormal_basement_membrane	1.03834274
48	MP0003191_abnormal_cellular_cholesterol	1.03820772
49	MP0000350_abnormal_cell_proliferation	1.03028553
50	MP0002210_abnormal_sex_determination	1.02887955
51	MP0002089_abnormal_postnatal_growth/wei	1.02605892
52	MP0005395_other_phenotype	1.00722193
53	MP0005319_abnormal_enzyme/_coenzyme	0.99018410
54	MP0005380_embryogenesis_phenotype	0.97376277
55	MP0001672_abnormal_embryogenesis/_devel	0.97376277
56	MP0001929_abnormal_gametogenesis	0.97212181
57	MP0001529_abnormal_vocalization	0.96520940
58	MP0002282_abnormal_trachea_morphology	0.95318601
59	MP0002118_abnormal_lipid_homeostasis	0.94426645
60	MP0005671_abnormal_response_to	0.94264114
61	MP0001697_abnormal_embryo_size	0.93004466
62	MP0000598_abnormal_liver_morphology	0.92712630
63	MP0003567_abnormal_fetal_cardiomyocyte	0.92336988
64	MP0005584_abnormal_enzyme/coenzyme_acti	0.92024509
65	MP0003984_embryonic_growth_retardation	0.90385163
66	MP0001915_intracranial_hemorrhage	0.90325767
67	MP0002088_abnormal_embryonic_growth/wei	0.89013904
68	MP0003943_abnormal_hepatobiliary_system	0.88333546
69	MP0001853_heart_inflammation	0.83764754
70	MP0000639_abnormal_adrenal_gland	0.80666405
71	MP0002080_prenatal_lethality	0.80557084
72	MP0003786_premature_aging	0.79606429
73	MP0010352_gastrointestinal_tract_polyps	0.78994037
74	MP0002160_abnormal_reproductive_system	0.78414132
75	MP0009643_abnormal_urine_homeostasis	0.77484113
76	MP0005636_abnormal_mineral_homeostasis	0.76639619
77	MP0001145_abnormal_male_reproductive	0.76024384
78	MP0002163_abnormal_gland_morphology	0.75898337
79	MP0000313_abnormal_cell_death	0.74396862
80	MP0005408_hypopigmentation	0.74355628
81	MP0002086_abnormal_extraembryonic_tissu	0.74288089
82	MP0005220_abnormal_exocrine_pancreas	0.72679582
83	MP0001984_abnormal_olfaction	0.72187890
84	MP0008260_abnormal_autophagy	0.70032354
85	MP0000647_abnormal_sebaceous_gland	0.69989224
86	MP0000653_abnormal_sex_gland	0.68911763
87	MP0003699_abnormal_female_reproductive	0.67232420
88	MP0002006_tumorigenesis	0.66953655
89	MP0009333_abnormal_splenocyte_physiolog	0.66763209
90	MP0005379_endocrine/exocrine_gland_phen	0.66155662
91	MP0005376_homeostasis/metabolism_phenot	0.65975844
92	MP0009642_abnormal_blood_homeostasis	0.62904406
93	MP0008469_abnormal_protein_level	0.62635076
94	MP0005646_abnormal_pituitary_gland	0.61892140
95	MP0005384_cellular_phenotype	0.61004930
96	MP0005058_abnormal_lysosome_morphology	0.60559685
97	MP0002019_abnormal_tumor_incidence	0.60224958
98	MP0005410_abnormal_fertilization	0.58315903
99	MP0009763_increased_sensitivity_to	0.57933721
100	MP0001790_abnormal_immune_system	0.57911196

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	5.46584161
2	Abnormal gallbladder physiology (HP:0012438)	4.91389495
3	Cholecystitis (HP:0001082)	4.91389495
4	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.56921450
5	Abnormality of glycolysis (HP:0004366)	4.44159205
6	Deep venous thrombosis (HP:0002625)	4.13992620
7	Reduced antithrombin III activity (HP:0001976)	4.08258767
8	Increased serum pyruvate (HP:0003542)	3.83051840
9	Gout (HP:0001997)	3.80038314
10	Hypobetalipoproteinemia (HP:0003563)	3.60044467
11	Gastrointestinal stroma tumor (HP:0100723)	3.34928872
12	Dry hair (HP:0011359)	3.32468964
13	IgA deficiency (HP:0002720)	3.29702169
14	Type I transferrin isoform profile (HP:0003642)	3.18511531
15	Hypoglycemic coma (HP:0001325)	3.05427356
16	Abnormality of methionine metabolism (HP:0010901)	2.99574919
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99093818
18	Joint hemorrhage (HP:0005261)	2.96224149
19	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.91027468
20	Generalized aminoaciduria (HP:0002909)	2.90403041
21	Abnormality of the intrinsic pathway (HP:0010989)	2.89518409
22	Hypoglycemic seizures (HP:0002173)	2.88998028
23	Hypoplasia of the uterus (HP:0000013)	2.86037260
24	Abnormality of the common coagulation pathway (HP:0010990)	2.73816922
25	Intrahepatic cholestasis (HP:0001406)	2.71382167
26	Hyperglycinemia (HP:0002154)	2.64759721
27	Cerebral edema (HP:0002181)	2.61144088
28	Squamous cell carcinoma (HP:0002860)	2.60298314
29	Acute necrotizing encephalopathy (HP:0006965)	2.60214957
30	Entropion (HP:0000621)	2.57627860
31	Acute encephalopathy (HP:0006846)	2.52557195
32	Onycholysis (HP:0001806)	2.49769432
33	Microvesicular hepatic steatosis (HP:0001414)	2.47594578
34	Symptomatic seizures (HP:0011145)	2.47268270
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.41497770
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.41497770
37	Abnormal protein glycosylation (HP:0012346)	2.41497770
38	Abnormal glycosylation (HP:0012345)	2.41497770
39	Hyperinsulinemic hypoglycemia (HP:0000825)	2.41162699
40	Increased CSF lactate (HP:0002490)	2.37135017
41	Osteomalacia (HP:0002749)	2.36834163
42	Spontaneous abortion (HP:0005268)	2.32615788
43	Pigmentary retinal degeneration (HP:0001146)	2.29295037
44	Poikiloderma (HP:0001029)	2.28492830
45	Xanthomatosis (HP:0000991)	2.27683116
46	Proximal tubulopathy (HP:0000114)	2.26297467
47	Conjugated hyperbilirubinemia (HP:0002908)	2.23016871
48	Hypercholesterolemia (HP:0003124)	2.21349917
49	Recurrent sinusitis (HP:0011108)	2.21332435
50	Rhabdomyolysis (HP:0003201)	2.16965494
51	Glycosuria (HP:0003076)	2.15219850
52	Abnormality of urine glucose concentration (HP:0011016)	2.15219850
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.15013458
54	Small epiphyses (HP:0010585)	2.13926496
55	Ketosis (HP:0001946)	2.13912026
56	Increased serum lactate (HP:0002151)	2.13754211
57	Abnormality of pyrimidine metabolism (HP:0004353)	2.13276023
58	Lipid accumulation in hepatocytes (HP:0006561)	2.12165694
59	Hepatic necrosis (HP:0002605)	2.12051293
60	IgM deficiency (HP:0002850)	2.09188898
61	Hypolipoproteinemia (HP:0010981)	2.08504197
62	Renal Fanconi syndrome (HP:0001994)	2.04430346
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.04342569
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03813896
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03813896
66	Progressive macrocephaly (HP:0004481)	2.02806663
67	Hyperammonemia (HP:0001987)	2.01913917
68	Recurrent bronchitis (HP:0002837)	1.98849297
69	Mitochondrial inheritance (HP:0001427)	1.97846864
70	Unilateral renal agenesis (HP:0000122)	1.96430432
71	Cholelithiasis (HP:0001081)	1.96428011
72	Lactic acidosis (HP:0003128)	1.94124185
73	Pancreatic islet-cell hyperplasia (HP:0004510)	1.92555542
74	Exercise intolerance (HP:0003546)	1.92347683
75	Complement deficiency (HP:0004431)	1.91845160
76	Abnormality of endocrine pancreas physiology (HP:0012093)	1.91818085
77	Abnormality of the pancreatic islet cells (HP:0006476)	1.91818085
78	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91515697
79	Abnormality of nucleobase metabolism (HP:0010932)	1.91354234
80	Elevated hepatic transaminases (HP:0002910)	1.89765775
81	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.89066189
82	Increased hepatocellular lipid droplets (HP:0006565)	1.88740001
83	Ridged nail (HP:0001807)	1.88525488
84	Abnormality of DNA repair (HP:0003254)	1.87723332
85	Hepatocellular necrosis (HP:0001404)	1.86397173
86	Vaginal fistula (HP:0004320)	1.86314453
87	Lower limb hyperreflexia (HP:0002395)	1.86154307
88	Epiphyseal stippling (HP:0010655)	1.85068065
89	Lethargy (HP:0001254)	1.84546281
90	Myoglobinuria (HP:0002913)	1.84474613
91	Hypergonadotropic hypogonadism (HP:0000815)	1.81840958
92	Abnormality of purine metabolism (HP:0004352)	1.81306747
93	Sensorimotor neuropathy (HP:0007141)	1.80960691
94	Conical tooth (HP:0000698)	1.80038486
95	Increased intramyocellular lipid droplets (HP:0012240)	1.79920928
96	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.78477094
97	Hyperglycinuria (HP:0003108)	1.78338966
98	Metabolic acidosis (HP:0001942)	1.78020245
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.77438861
100	Abnormality of glycine metabolism (HP:0010895)	1.77438861

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK1	4.41820883
2	ZAK	3.89760093
3	MST4	3.70931855
4	PBK	3.48514049
5	NEK1	3.29147458
6	EIF2AK3	3.24114317
7	BUB1	2.81255440
8	TLK1	2.63495532
9	DAPK3	2.34161056
10	EIF2AK1	2.25321451
11	VRK2	2.02174346
12	BCKDK	1.98386520
13	FLT3	1.96238489
14	TSSK6	1.87086077
15	MAP3K9	1.86660603
16	STK24	1.81496261
17	FGFR4	1.79302775
18	AURKA	1.70803687
19	RPS6KA5	1.68758593
20	WEE1	1.61764010
21	ARAF	1.51387196
22	NME2	1.46957052
23	PDK2	1.45941701
24	SRPK1	1.40999080
25	CDC7	1.40891214
26	PKN2	1.34481848
27	TTK	1.31507172
28	BMPR2	1.29097823
29	MAP3K12	1.27439993
30	TAF1	1.19861435
31	SMG1	1.18678723
32	MAP3K8	1.18659409
33	STK10	1.11807830
34	FGFR1	1.07522351
35	TNIK	1.07432224
36	AURKB	1.06965705
37	PIM2	1.04223561
38	STK4	1.03758304
39	KSR2	1.03259903
40	MST1R	0.98379207
41	CDK8	0.98303441
42	ICK	0.95712463
43	CHEK2	0.95298758
44	PKN1	0.95143698
45	PLK1	0.94483651
46	AKT2	0.94242021
47	NME1	0.92024251
48	PLK3	0.88025986
49	PNCK	0.87366866
50	MATK	0.85906297
51	CDK7	0.85666344
52	RPS6KB2	0.85160152
53	WNK4	0.84410049
54	IRAK3	0.84216138
55	NEK9	0.84171797
56	STK16	0.83413497
57	RAF1	0.81904488
58	CDK12	0.80033712
59	LATS2	0.77479226
60	FGFR3	0.77277073
61	EPHA2	0.76921220
62	PRKD3	0.76864977
63	BRSK1	0.75411377
64	CHEK1	0.71613852
65	SIK2	0.70506574
66	MET	0.68011728
67	ATR	0.67249719
68	CSNK2A2	0.66512734
69	PAK4	0.65813330
70	NEK2	0.64376778
71	PAK1	0.59841098
72	BRSK2	0.59657739
73	MUSK	0.58197529
74	MAP3K2	0.55729906
75	CSNK2A1	0.54790645
76	DAPK1	0.51100001
77	BMPR1B	0.49590049
78	IRAK4	0.46369223
79	DYRK3	0.46072359
80	EIF2AK2	0.45575475
81	ERBB4	0.45491303
82	STK39	0.43679839
83	ALK	0.42453343
84	PIM1	0.41616602
85	BRAF	0.41174553
86	NUAK1	0.40670837
87	PRKCQ	0.38174474
88	MAPK11	0.36885467
89	STK3	0.36240565
90	IKBKB	0.35766776
91	ATM	0.35712215
92	MAPKAPK5	0.32437836
93	CSNK1G1	0.31032992
94	CDK9	0.29848083
95	PRKCI	0.29769742
96	MAP3K14	0.29170229
97	CLK1	0.28920074
98	AKT3	0.28834880
99	FGR	0.27791252
100	CAMK2G	0.27484879

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.11225790
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.51966971
3	Alcoholism_Homo sapiens_hsa05034	3.05130337
4	Proteasome_Homo sapiens_hsa03050	2.41888074
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.96845788
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90585484
7	Steroid biosynthesis_Homo sapiens_hsa00100	1.89305466
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.85314916
9	DNA replication_Homo sapiens_hsa03030	1.83797873
10	Phenylalanine metabolism_Homo sapiens_hsa00360	1.81884056
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.76915950
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.76883459
13	Complement and coagulation cascades_Homo sapiens_hsa04610	1.72053440
14	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.69162888
15	One carbon pool by folate_Homo sapiens_hsa00670	1.67637244
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.63647905
17	Fatty acid elongation_Homo sapiens_hsa00062	1.63498005
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.62984228
19	Mismatch repair_Homo sapiens_hsa03430	1.62150681
20	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.61718108
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58312745
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.56890158
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.54939740
24	Carbon metabolism_Homo sapiens_hsa01200	1.53018325
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.52469864
26	Folate biosynthesis_Homo sapiens_hsa00790	1.51537805
27	Base excision repair_Homo sapiens_hsa03410	1.50668444
28	Protein export_Homo sapiens_hsa03060	1.41641071
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.35777775
30	Galactose metabolism_Homo sapiens_hsa00052	1.35458108
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.35012541
32	Glutathione metabolism_Homo sapiens_hsa00480	1.32451267
33	RNA polymerase_Homo sapiens_hsa03020	1.28365348
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24236805
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.23322014
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.23187357
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.22164228
38	Viral carcinogenesis_Homo sapiens_hsa05203	1.20671868
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20014868
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15882113
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.15830571
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.13219692
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13038691
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.13029616
45	Sulfur relay system_Homo sapiens_hsa04122	1.10543155
46	Pentose phosphate pathway_Homo sapiens_hsa00030	1.08466118
47	Spliceosome_Homo sapiens_hsa03040	1.07075007
48	Asthma_Homo sapiens_hsa05310	1.04972183
49	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04638408
50	Tyrosine metabolism_Homo sapiens_hsa00350	1.04609559
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03886445
52	Peroxisome_Homo sapiens_hsa04146	1.03246643
53	Arginine and proline metabolism_Homo sapiens_hsa00330	1.01316141
54	Allograft rejection_Homo sapiens_hsa05330	0.99704303
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99384024
56	Parkinsons disease_Homo sapiens_hsa05012	0.98637262
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.98048421
58	Fatty acid degradation_Homo sapiens_hsa00071	0.97910706
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.95747349
60	Ribosome_Homo sapiens_hsa03010	0.95064678
61	RNA transport_Homo sapiens_hsa03013	0.94795942
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93184999
63	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91707447
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.91551287
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.91433358
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91141495
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89767454
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.84630840
69	RNA degradation_Homo sapiens_hsa03018	0.83999528
70	Butanoate metabolism_Homo sapiens_hsa00650	0.81860160
71	Basal transcription factors_Homo sapiens_hsa03022	0.80560941
72	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.78494622
73	Huntingtons disease_Homo sapiens_hsa05016	0.74324432
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71118575
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.70637431
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67706383
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66610040
78	Sulfur metabolism_Homo sapiens_hsa00920	0.65444197
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61848903
80	Homologous recombination_Homo sapiens_hsa03440	0.61575825
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.60811100
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.59841014
83	Metabolic pathways_Homo sapiens_hsa01100	0.59579679
84	Cell cycle_Homo sapiens_hsa04110	0.56637967
85	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55496020
86	PPAR signaling pathway_Homo sapiens_hsa03320	0.53942262
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.53355594
88	p53 signaling pathway_Homo sapiens_hsa04115	0.52656401
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51081453
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49390438
91	Graft-versus-host disease_Homo sapiens_hsa05332	0.47058900
92	Purine metabolism_Homo sapiens_hsa00230	0.46934389
93	Viral myocarditis_Homo sapiens_hsa05416	0.46338498
94	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44932708
95	Caffeine metabolism_Homo sapiens_hsa00232	0.42184615
96	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.41879248
97	Fanconi anemia pathway_Homo sapiens_hsa03460	0.40763112
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.38296887
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37489388
100	Retinol metabolism_Homo sapiens_hsa00830	0.34713003

AK4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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