AK4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)4.80877545
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.74997788
3L-phenylalanine metabolic process (GO:0006558)4.74997788
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.31264424
5L-phenylalanine catabolic process (GO:0006559)4.31264424
6proteasome assembly (GO:0043248)4.26176172
7proline metabolic process (GO:0006560)4.19036958
8very-low-density lipoprotein particle assembly (GO:0034379)4.12776880
9negative regulation of myeloid cell apoptotic process (GO:0033033)3.78751103
10ribosome assembly (GO:0042255)3.64815442
11peptidyl-glutamic acid carboxylation (GO:0017187)3.58242408
12protein carboxylation (GO:0018214)3.58242408
13intestinal cholesterol absorption (GO:0030299)3.48193018
14negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.47004601
15transcription from mitochondrial promoter (GO:0006390)3.46788280
16innate immune response in mucosa (GO:0002227)3.34481517
17regulation of mitochondrial translation (GO:0070129)3.28742644
18negative regulation of fibrinolysis (GO:0051918)3.25292699
19plasma lipoprotein particle assembly (GO:0034377)3.21758782
20RNA localization (GO:0006403)3.18857723
21establishment of viral latency (GO:0019043)3.15169995
22regulation of protein activation cascade (GO:2000257)3.14780368
23regulation of retinoic acid receptor signaling pathway (GO:0048385)3.12596347
24regulation of bile acid biosynthetic process (GO:0070857)3.10218983
25regulation of fibrinolysis (GO:0051917)3.09051671
26glutamine family amino acid biosynthetic process (GO:0009084)3.08667915
27cholesterol efflux (GO:0033344)3.06884131
28maturation of 5.8S rRNA (GO:0000460)3.06638337
294-hydroxyproline metabolic process (GO:0019471)3.06531615
30negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.06315645
31regulation of cholesterol homeostasis (GO:2000188)3.03707738
32glucose 6-phosphate metabolic process (GO:0051156)3.03687463
33protein maturation by protein folding (GO:0022417)2.99543541
34glycolytic process (GO:0006096)2.99501917
35dicarboxylic acid biosynthetic process (GO:0043650)2.98838549
36establishment of integrated proviral latency (GO:0075713)2.96200617
37mucosal immune response (GO:0002385)2.94168253
38cellular modified amino acid catabolic process (GO:0042219)2.93549709
39regulation of complement activation (GO:0030449)2.92371754
40aromatic amino acid family catabolic process (GO:0009074)2.92205660
41gluconeogenesis (GO:0006094)2.88306812
42negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.87778081
43hexose biosynthetic process (GO:0019319)2.87201234
44blood coagulation, intrinsic pathway (GO:0007597)2.84121869
45GDP-mannose metabolic process (GO:0019673)2.83070123
46triglyceride homeostasis (GO:0070328)2.81680276
47acylglycerol homeostasis (GO:0055090)2.81680276
48COPII vesicle coating (GO:0048208)2.81539069
49ribosome biogenesis (GO:0042254)2.80183158
50tetrahydrofolate metabolic process (GO:0046653)2.79870494
51regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.79703927
52regulation of prostaglandin secretion (GO:0032306)2.77921101
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75912934
54deoxyribonucleotide biosynthetic process (GO:0009263)2.75118807
55branched-chain amino acid catabolic process (GO:0009083)2.74621405
56organ or tissue specific immune response (GO:0002251)2.71026835
57protein-lipid complex assembly (GO:0065005)2.70226975
58monosaccharide biosynthetic process (GO:0046364)2.69455648
59rRNA modification (GO:0000154)2.68765172
60positive regulation of humoral immune response (GO:0002922)2.66571990
61DNA catabolic process, exonucleolytic (GO:0000738)2.65269612
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63714291
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61867555
64xenobiotic catabolic process (GO:0042178)2.61590511
65binding of sperm to zona pellucida (GO:0007339)2.61209839
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61008140
67negative regulation of sterol transport (GO:0032372)2.59922114
68negative regulation of cholesterol transport (GO:0032375)2.59922114
69rRNA methylation (GO:0031167)2.59095064
70activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.58064319
712-deoxyribonucleotide biosynthetic process (GO:0009265)2.56609400
72deoxyribose phosphate biosynthetic process (GO:0046385)2.56609400
73chaperone-mediated protein complex assembly (GO:0051131)2.55890483
74mitochondrial RNA metabolic process (GO:0000959)2.54793398
75pyruvate metabolic process (GO:0006090)2.53224665
76glutamate metabolic process (GO:0006536)2.52822970
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51252244
78pteridine-containing compound biosynthetic process (GO:0042559)2.50728701
79cysteine metabolic process (GO:0006534)2.49962863
80L-ascorbic acid metabolic process (GO:0019852)2.49538045
81chromatin assembly (GO:0031497)2.49131758
82regulation of cellular amino acid metabolic process (GO:0006521)2.47710198
83formation of translation preinitiation complex (GO:0001731)2.47447399
84positive regulation of cellular amine metabolic process (GO:0033240)2.46409459
85ribosomal large subunit biogenesis (GO:0042273)2.46194674
86daunorubicin metabolic process (GO:0044597)2.46193768
87polyketide metabolic process (GO:0030638)2.46193768
88doxorubicin metabolic process (GO:0044598)2.46193768
89spliceosomal snRNP assembly (GO:0000387)2.46056831
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44815616
91tricarboxylic acid cycle (GO:0006099)2.44126877
92DNA replication-dependent nucleosome organization (GO:0034723)2.42873990
93DNA replication-dependent nucleosome assembly (GO:0006335)2.42873990
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42477068
95pseudouridine synthesis (GO:0001522)2.42098145
96rRNA processing (GO:0006364)2.41613488
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41385107
98glycine metabolic process (GO:0006544)2.40543582
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39242484
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.38237214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.04809044
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.83432671
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01726162
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.34921811
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.23623052
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98992782
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94700729
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86395914
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81633132
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72978427
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.64055375
12ZNF263_19887448_ChIP-Seq_K562_Human2.63322471
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62618704
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55043435
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53674634
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51881045
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.49863244
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49230137
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43395194
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.38639444
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38293370
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37354108
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.30009417
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19468477
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09436470
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08277173
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05442236
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03493484
29VDR_23849224_ChIP-Seq_CD4+_Human2.02523247
30AR_21909140_ChIP-Seq_LNCAP_Human1.99464688
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92751957
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91872089
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90393628
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88526706
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88129700
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86620875
37ELK1_19687146_ChIP-ChIP_HELA_Human1.85694308
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.84960479
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83523994
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81411813
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.80655312
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75921225
43GABP_19822575_ChIP-Seq_HepG2_Human1.75253865
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75231701
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.66757966
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.63147521
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62520719
48HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62400904
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61801082
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59939706
51FOXP3_21729870_ChIP-Seq_TREG_Human1.59050642
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55463615
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55029106
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54955697
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53559366
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.52760387
57XRN2_22483619_ChIP-Seq_HELA_Human1.50005126
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46412252
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46154469
60IRF1_19129219_ChIP-ChIP_H3396_Human1.45293221
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43431022
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40978586
63TTF2_22483619_ChIP-Seq_HELA_Human1.37090844
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36635498
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35999720
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35346130
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32400849
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31195086
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29286068
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29111950
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22311026
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21861589
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14582009
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14487525
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13935844
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13319760
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11683308
78KDM5A_27292631_Chip-Seq_BREAST_Human1.10778651
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09616810
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05232598
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.04662336
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04028486
83TFEB_21752829_ChIP-Seq_HELA_Human1.03424815
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03115149
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02216511
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01322153
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01167273
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01153562
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01124884
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99441977
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99171210
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.98587323
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.97847181
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95178929
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94590414
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92555680
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.91620007
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.91381345
99MYC_18940864_ChIP-ChIP_HL60_Human0.90214747
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89437696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.63286782
2MP0005645_abnormal_hypothalamus_physiol3.85713257
3MP0005360_urolithiasis3.56315543
4MP0003806_abnormal_nucleotide_metabolis3.49820141
5MP0002138_abnormal_hepatobiliary_system3.03935095
6MP0003693_abnormal_embryo_hatching2.92112291
7MP0009697_abnormal_copulation2.85868261
8MP0005365_abnormal_bile_salt2.80525392
9MP0005085_abnormal_gallbladder_physiolo2.74076299
10MP0008875_abnormal_xenobiotic_pharmacok2.67610593
11MP0003868_abnormal_feces_composition2.66800900
12MP0004957_abnormal_blastocyst_morpholog2.63639217
13MP0003195_calcinosis2.61512713
14MP0008058_abnormal_DNA_repair2.61339467
15MP0005451_abnormal_body_composition2.60929601
16MP0010094_abnormal_chromosome_stability2.48268068
17MP0001666_abnormal_nutrient_absorption2.27490335
18MP0003718_maternal_effect2.17701482
19MP0003186_abnormal_redox_activity2.09186428
20MP0003111_abnormal_nucleus_morphology2.06883449
21MP0003950_abnormal_plasma_membrane2.04986838
22MP0008057_abnormal_DNA_replication2.01492519
23MP0001764_abnormal_homeostasis1.98601319
24MP0003077_abnormal_cell_cycle1.98056992
25MP0003941_abnormal_skin_development1.85233829
26MP0006035_abnormal_mitochondrial_morpho1.75030673
27MP0001727_abnormal_embryo_implantation1.69122028
28MP0005084_abnormal_gallbladder_morpholo1.68720678
29MP0005332_abnormal_amino_acid1.67898329
30MP0001881_abnormal_mammary_gland1.63291510
31MP0010329_abnormal_lipoprotein_level1.57498246
32MP0003252_abnormal_bile_duct1.56168223
33MP0000685_abnormal_immune_system1.51496411
34MP0000358_abnormal_cell_content/1.48992782
35MP0001661_extended_life_span1.44475052
36MP0000609_abnormal_liver_physiology1.36247729
37MP0008007_abnormal_cellular_replicative1.32834170
38MP0002132_abnormal_respiratory_system1.32087181
39MP0008932_abnormal_embryonic_tissue1.30601633
40MP0003183_abnormal_peptide_metabolism1.25898536
41MP0009046_muscle_twitch1.10857867
42MP0004233_abnormal_muscle_weight1.10748429
43MP0010307_abnormal_tumor_latency1.10268785
44MP0001730_embryonic_growth_arrest1.09301138
45MP0004019_abnormal_vitamin_homeostasis1.05166778
46MP0006036_abnormal_mitochondrial_physio1.03848774
47MP0004272_abnormal_basement_membrane1.03834274
48MP0003191_abnormal_cellular_cholesterol1.03820772
49MP0000350_abnormal_cell_proliferation1.03028553
50MP0002210_abnormal_sex_determination1.02887955
51MP0002089_abnormal_postnatal_growth/wei1.02605892
52MP0005395_other_phenotype1.00722193
53MP0005319_abnormal_enzyme/_coenzyme0.99018410
54MP0005380_embryogenesis_phenotype0.97376277
55MP0001672_abnormal_embryogenesis/_devel0.97376277
56MP0001929_abnormal_gametogenesis0.97212181
57MP0001529_abnormal_vocalization0.96520940
58MP0002282_abnormal_trachea_morphology0.95318601
59MP0002118_abnormal_lipid_homeostasis0.94426645
60MP0005671_abnormal_response_to0.94264114
61MP0001697_abnormal_embryo_size0.93004466
62MP0000598_abnormal_liver_morphology0.92712630
63MP0003567_abnormal_fetal_cardiomyocyte0.92336988
64MP0005584_abnormal_enzyme/coenzyme_acti0.92024509
65MP0003984_embryonic_growth_retardation0.90385163
66MP0001915_intracranial_hemorrhage0.90325767
67MP0002088_abnormal_embryonic_growth/wei0.89013904
68MP0003943_abnormal_hepatobiliary_system0.88333546
69MP0001853_heart_inflammation0.83764754
70MP0000639_abnormal_adrenal_gland0.80666405
71MP0002080_prenatal_lethality0.80557084
72MP0003786_premature_aging0.79606429
73MP0010352_gastrointestinal_tract_polyps0.78994037
74MP0002160_abnormal_reproductive_system0.78414132
75MP0009643_abnormal_urine_homeostasis0.77484113
76MP0005636_abnormal_mineral_homeostasis0.76639619
77MP0001145_abnormal_male_reproductive0.76024384
78MP0002163_abnormal_gland_morphology0.75898337
79MP0000313_abnormal_cell_death0.74396862
80MP0005408_hypopigmentation0.74355628
81MP0002086_abnormal_extraembryonic_tissu0.74288089
82MP0005220_abnormal_exocrine_pancreas0.72679582
83MP0001984_abnormal_olfaction0.72187890
84MP0008260_abnormal_autophagy0.70032354
85MP0000647_abnormal_sebaceous_gland0.69989224
86MP0000653_abnormal_sex_gland0.68911763
87MP0003699_abnormal_female_reproductive0.67232420
88MP0002006_tumorigenesis0.66953655
89MP0009333_abnormal_splenocyte_physiolog0.66763209
90MP0005379_endocrine/exocrine_gland_phen0.66155662
91MP0005376_homeostasis/metabolism_phenot0.65975844
92MP0009642_abnormal_blood_homeostasis0.62904406
93MP0008469_abnormal_protein_level0.62635076
94MP0005646_abnormal_pituitary_gland0.61892140
95MP0005384_cellular_phenotype0.61004930
96MP0005058_abnormal_lysosome_morphology0.60559685
97MP0002019_abnormal_tumor_incidence0.60224958
98MP0005410_abnormal_fertilization0.58315903
99MP0009763_increased_sensitivity_to0.57933721
100MP0001790_abnormal_immune_system0.57911196

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)5.46584161
2Abnormal gallbladder physiology (HP:0012438)4.91389495
3Cholecystitis (HP:0001082)4.91389495
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.56921450
5Abnormality of glycolysis (HP:0004366)4.44159205
6Deep venous thrombosis (HP:0002625)4.13992620
7Reduced antithrombin III activity (HP:0001976)4.08258767
8Increased serum pyruvate (HP:0003542)3.83051840
9Gout (HP:0001997)3.80038314
10Hypobetalipoproteinemia (HP:0003563)3.60044467
11Gastrointestinal stroma tumor (HP:0100723)3.34928872
12Dry hair (HP:0011359)3.32468964
13IgA deficiency (HP:0002720)3.29702169
14Type I transferrin isoform profile (HP:0003642)3.18511531
15Hypoglycemic coma (HP:0001325)3.05427356
16Abnormality of methionine metabolism (HP:0010901)2.99574919
17Abnormal mitochondria in muscle tissue (HP:0008316)2.99093818
18Joint hemorrhage (HP:0005261)2.96224149
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91027468
20Generalized aminoaciduria (HP:0002909)2.90403041
21Abnormality of the intrinsic pathway (HP:0010989)2.89518409
22Hypoglycemic seizures (HP:0002173)2.88998028
23Hypoplasia of the uterus (HP:0000013)2.86037260
24Abnormality of the common coagulation pathway (HP:0010990)2.73816922
25Intrahepatic cholestasis (HP:0001406)2.71382167
26Hyperglycinemia (HP:0002154)2.64759721
27Cerebral edema (HP:0002181)2.61144088
28Squamous cell carcinoma (HP:0002860)2.60298314
29Acute necrotizing encephalopathy (HP:0006965)2.60214957
30Entropion (HP:0000621)2.57627860
31Acute encephalopathy (HP:0006846)2.52557195
32Onycholysis (HP:0001806)2.49769432
33Microvesicular hepatic steatosis (HP:0001414)2.47594578
34Symptomatic seizures (HP:0011145)2.47268270
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41497770
36Abnormal protein N-linked glycosylation (HP:0012347)2.41497770
37Abnormal protein glycosylation (HP:0012346)2.41497770
38Abnormal glycosylation (HP:0012345)2.41497770
39Hyperinsulinemic hypoglycemia (HP:0000825)2.41162699
40Increased CSF lactate (HP:0002490)2.37135017
41Osteomalacia (HP:0002749)2.36834163
42Spontaneous abortion (HP:0005268)2.32615788
43Pigmentary retinal degeneration (HP:0001146)2.29295037
44Poikiloderma (HP:0001029)2.28492830
45Xanthomatosis (HP:0000991)2.27683116
46Proximal tubulopathy (HP:0000114)2.26297467
47Conjugated hyperbilirubinemia (HP:0002908)2.23016871
48Hypercholesterolemia (HP:0003124)2.21349917
49Recurrent sinusitis (HP:0011108)2.21332435
50Rhabdomyolysis (HP:0003201)2.16965494
51Glycosuria (HP:0003076)2.15219850
52Abnormality of urine glucose concentration (HP:0011016)2.15219850
53Aplasia/hypoplasia of the uterus (HP:0008684)2.15013458
54Small epiphyses (HP:0010585)2.13926496
55Ketosis (HP:0001946)2.13912026
56Increased serum lactate (HP:0002151)2.13754211
57Abnormality of pyrimidine metabolism (HP:0004353)2.13276023
58Lipid accumulation in hepatocytes (HP:0006561)2.12165694
59Hepatic necrosis (HP:0002605)2.12051293
60IgM deficiency (HP:0002850)2.09188898
61Hypolipoproteinemia (HP:0010981)2.08504197
62Renal Fanconi syndrome (HP:0001994)2.04430346
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04342569
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03813896
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03813896
66Progressive macrocephaly (HP:0004481)2.02806663
67Hyperammonemia (HP:0001987)2.01913917
68Recurrent bronchitis (HP:0002837)1.98849297
69Mitochondrial inheritance (HP:0001427)1.97846864
70Unilateral renal agenesis (HP:0000122)1.96430432
71Cholelithiasis (HP:0001081)1.96428011
72Lactic acidosis (HP:0003128)1.94124185
73Pancreatic islet-cell hyperplasia (HP:0004510)1.92555542
74Exercise intolerance (HP:0003546)1.92347683
75Complement deficiency (HP:0004431)1.91845160
76Abnormality of endocrine pancreas physiology (HP:0012093)1.91818085
77Abnormality of the pancreatic islet cells (HP:0006476)1.91818085
78Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91515697
79Abnormality of nucleobase metabolism (HP:0010932)1.91354234
80Elevated hepatic transaminases (HP:0002910)1.89765775
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89066189
82Increased hepatocellular lipid droplets (HP:0006565)1.88740001
83Ridged nail (HP:0001807)1.88525488
84Abnormality of DNA repair (HP:0003254)1.87723332
85Hepatocellular necrosis (HP:0001404)1.86397173
86Vaginal fistula (HP:0004320)1.86314453
87Lower limb hyperreflexia (HP:0002395)1.86154307
88Epiphyseal stippling (HP:0010655)1.85068065
89Lethargy (HP:0001254)1.84546281
90Myoglobinuria (HP:0002913)1.84474613
91Hypergonadotropic hypogonadism (HP:0000815)1.81840958
92Abnormality of purine metabolism (HP:0004352)1.81306747
93Sensorimotor neuropathy (HP:0007141)1.80960691
94Conical tooth (HP:0000698)1.80038486
95Increased intramyocellular lipid droplets (HP:0012240)1.79920928
96Abnormality of sulfur amino acid metabolism (HP:0004339)1.78477094
97Hyperglycinuria (HP:0003108)1.78338966
98Metabolic acidosis (HP:0001942)1.78020245
99Abnormality of serine family amino acid metabolism (HP:0010894)1.77438861
100Abnormality of glycine metabolism (HP:0010895)1.77438861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK14.41820883
2ZAK3.89760093
3MST43.70931855
4PBK3.48514049
5NEK13.29147458
6EIF2AK33.24114317
7BUB12.81255440
8TLK12.63495532
9DAPK32.34161056
10EIF2AK12.25321451
11VRK22.02174346
12BCKDK1.98386520
13FLT31.96238489
14TSSK61.87086077
15MAP3K91.86660603
16STK241.81496261
17FGFR41.79302775
18AURKA1.70803687
19RPS6KA51.68758593
20WEE11.61764010
21ARAF1.51387196
22NME21.46957052
23PDK21.45941701
24SRPK11.40999080
25CDC71.40891214
26PKN21.34481848
27TTK1.31507172
28BMPR21.29097823
29MAP3K121.27439993
30TAF11.19861435
31SMG11.18678723
32MAP3K81.18659409
33STK101.11807830
34FGFR11.07522351
35TNIK1.07432224
36AURKB1.06965705
37PIM21.04223561
38STK41.03758304
39KSR21.03259903
40MST1R0.98379207
41CDK80.98303441
42ICK0.95712463
43CHEK20.95298758
44PKN10.95143698
45PLK10.94483651
46AKT20.94242021
47NME10.92024251
48PLK30.88025986
49PNCK0.87366866
50MATK0.85906297
51CDK70.85666344
52RPS6KB20.85160152
53WNK40.84410049
54IRAK30.84216138
55NEK90.84171797
56STK160.83413497
57RAF10.81904488
58CDK120.80033712
59LATS20.77479226
60FGFR30.77277073
61EPHA20.76921220
62PRKD30.76864977
63BRSK10.75411377
64CHEK10.71613852
65SIK20.70506574
66MET0.68011728
67ATR0.67249719
68CSNK2A20.66512734
69PAK40.65813330
70NEK20.64376778
71PAK10.59841098
72BRSK20.59657739
73MUSK0.58197529
74MAP3K20.55729906
75CSNK2A10.54790645
76DAPK10.51100001
77BMPR1B0.49590049
78IRAK40.46369223
79DYRK30.46072359
80EIF2AK20.45575475
81ERBB40.45491303
82STK390.43679839
83ALK0.42453343
84PIM10.41616602
85BRAF0.41174553
86NUAK10.40670837
87PRKCQ0.38174474
88MAPK110.36885467
89STK30.36240565
90IKBKB0.35766776
91ATM0.35712215
92MAPKAPK50.32437836
93CSNK1G10.31032992
94CDK90.29848083
95PRKCI0.29769742
96MAP3K140.29170229
97CLK10.28920074
98AKT30.28834880
99FGR0.27791252
100CAMK2G0.27484879

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.11225790
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51966971
3Alcoholism_Homo sapiens_hsa050343.05130337
4Proteasome_Homo sapiens_hsa030502.41888074
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96845788
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90585484
7Steroid biosynthesis_Homo sapiens_hsa001001.89305466
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85314916
9DNA replication_Homo sapiens_hsa030301.83797873
10Phenylalanine metabolism_Homo sapiens_hsa003601.81884056
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76915950
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76883459
13Complement and coagulation cascades_Homo sapiens_hsa046101.72053440
14Biosynthesis of amino acids_Homo sapiens_hsa012301.69162888
15One carbon pool by folate_Homo sapiens_hsa006701.67637244
16Fructose and mannose metabolism_Homo sapiens_hsa000511.63647905
17Fatty acid elongation_Homo sapiens_hsa000621.63498005
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62984228
19Mismatch repair_Homo sapiens_hsa034301.62150681
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.61718108
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58312745
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.56890158
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.54939740
24Carbon metabolism_Homo sapiens_hsa012001.53018325
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52469864
26Folate biosynthesis_Homo sapiens_hsa007901.51537805
27Base excision repair_Homo sapiens_hsa034101.50668444
28Protein export_Homo sapiens_hsa030601.41641071
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35777775
30Galactose metabolism_Homo sapiens_hsa000521.35458108
31Pyruvate metabolism_Homo sapiens_hsa006201.35012541
32Glutathione metabolism_Homo sapiens_hsa004801.32451267
33RNA polymerase_Homo sapiens_hsa030201.28365348
34Propanoate metabolism_Homo sapiens_hsa006401.24236805
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.23322014
36Oxidative phosphorylation_Homo sapiens_hsa001901.23187357
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22164228
38Viral carcinogenesis_Homo sapiens_hsa052031.20671868
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20014868
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15882113
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15830571
42Fatty acid metabolism_Homo sapiens_hsa012121.13219692
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13038691
44Nucleotide excision repair_Homo sapiens_hsa034201.13029616
45Sulfur relay system_Homo sapiens_hsa041221.10543155
46Pentose phosphate pathway_Homo sapiens_hsa000301.08466118
47Spliceosome_Homo sapiens_hsa030401.07075007
48Asthma_Homo sapiens_hsa053101.04972183
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04638408
50Tyrosine metabolism_Homo sapiens_hsa003501.04609559
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.03886445
52Peroxisome_Homo sapiens_hsa041461.03246643
53Arginine and proline metabolism_Homo sapiens_hsa003301.01316141
54Allograft rejection_Homo sapiens_hsa053300.99704303
55Pyrimidine metabolism_Homo sapiens_hsa002400.99384024
56Parkinsons disease_Homo sapiens_hsa050120.98637262
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.98048421
58Fatty acid degradation_Homo sapiens_hsa000710.97910706
59Vitamin B6 metabolism_Homo sapiens_hsa007500.95747349
60Ribosome_Homo sapiens_hsa030100.95064678
61RNA transport_Homo sapiens_hsa030130.94795942
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93184999
63Type I diabetes mellitus_Homo sapiens_hsa049400.91707447
64N-Glycan biosynthesis_Homo sapiens_hsa005100.91551287
65Arginine biosynthesis_Homo sapiens_hsa002200.91433358
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91141495
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89767454
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84630840
69RNA degradation_Homo sapiens_hsa030180.83999528
70Butanoate metabolism_Homo sapiens_hsa006500.81860160
71Basal transcription factors_Homo sapiens_hsa030220.80560941
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78494622
73Huntingtons disease_Homo sapiens_hsa050160.74324432
74Autoimmune thyroid disease_Homo sapiens_hsa053200.71118575
75Starch and sucrose metabolism_Homo sapiens_hsa005000.70637431
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.67706383
77Chemical carcinogenesis_Homo sapiens_hsa052040.66610040
78Sulfur metabolism_Homo sapiens_hsa009200.65444197
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61848903
80Homologous recombination_Homo sapiens_hsa034400.61575825
81Vibrio cholerae infection_Homo sapiens_hsa051100.60811100
82Tryptophan metabolism_Homo sapiens_hsa003800.59841014
83Metabolic pathways_Homo sapiens_hsa011000.59579679
84Cell cycle_Homo sapiens_hsa041100.56637967
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55496020
86PPAR signaling pathway_Homo sapiens_hsa033200.53942262
87Non-homologous end-joining_Homo sapiens_hsa034500.53355594
88p53 signaling pathway_Homo sapiens_hsa041150.52656401
89Staphylococcus aureus infection_Homo sapiens_hsa051500.51081453
90Fatty acid biosynthesis_Homo sapiens_hsa000610.49390438
91Graft-versus-host disease_Homo sapiens_hsa053320.47058900
92Purine metabolism_Homo sapiens_hsa002300.46934389
93Viral myocarditis_Homo sapiens_hsa054160.46338498
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44932708
95Caffeine metabolism_Homo sapiens_hsa002320.42184615
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.41879248
97Fanconi anemia pathway_Homo sapiens_hsa034600.40763112
98Epstein-Barr virus infection_Homo sapiens_hsa051690.38296887
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37489388
100Retinol metabolism_Homo sapiens_hsa008300.34713003

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