ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chemosensory behavior (GO:0007635)	7.99431995
2	male sex determination (GO:0030238)	7.12674957
3	glucosamine-containing compound catabolic process (GO:1901072)	6.86777039
4	regulation of type B pancreatic cell apoptotic process (GO:2000674)	5.87093266
5	protein K6-linked ubiquitination (GO:0085020)	5.80059715
6	carnitine shuttle (GO:0006853)	5.68368998
7	autophagic vacuole fusion (GO:0000046)	5.52606543
8	adenosine metabolic process (GO:0046085)	5.48540834
9	sleep (GO:0030431)	5.01622193
10	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.92281542
11	carnitine transport (GO:0015879)	4.87502339
12	amino-acid betaine transport (GO:0015838)	4.87502339
13	antigen processing and presentation via MHC class Ib (GO:0002475)	4.85614204
14	fatty acid transmembrane transport (GO:1902001)	4.85328198
15	carnitine transmembrane transport (GO:1902603)	4.81209188
16	intracellular lipid transport (GO:0032365)	4.78442145
17	positive regulation of glycolytic process (GO:0045821)	4.68064630
18	coenzyme A biosynthetic process (GO:0015937)	4.62197246
19	response to lipoprotein particle (GO:0055094)	4.52651697
20	response to UV-C (GO:0010225)	4.32331866
21	amino sugar catabolic process (GO:0046348)	4.20459402
22	coenzyme A metabolic process (GO:0015936)	4.14026797
23	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	4.09858913
24	organelle membrane fusion (GO:0090174)	4.09811965
25	nitric oxide mediated signal transduction (GO:0007263)	3.98169952
26	positive regulation of cholesterol efflux (GO:0010875)	3.86051021
27	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.85234458
28	positive regulation of sterol transport (GO:0032373)	3.83536663
29	positive regulation of cholesterol transport (GO:0032376)	3.83536663
30	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.81757323
31	positive regulation of glycogen biosynthetic process (GO:0045725)	3.81453729
32	RNA destabilization (GO:0050779)	3.80799303
33	nucleotide transmembrane transport (GO:1901679)	3.80059137
34	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.68624523
35	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.65244581
36	response to acidic pH (GO:0010447)	3.65146366
37	sex determination (GO:0007530)	3.49193813
38	positive regulation of glycogen metabolic process (GO:0070875)	3.48590247
39	centrosome duplication (GO:0051298)	3.44386473
40	fatty acid homeostasis (GO:0055089)	3.41754262
41	quaternary ammonium group transport (GO:0015697)	3.39631671
42	arginine catabolic process (GO:0006527)	3.33186916
43	genitalia morphogenesis (GO:0035112)	3.27545910
44	oocyte maturation (GO:0001556)	3.27445735
45	negative regulation of peptidyl-serine phosphorylation (GO:0033137)	3.25755587
46	cellular response to leptin stimulus (GO:0044320)	3.24804238
47	regulation of B cell receptor signaling pathway (GO:0050855)	3.24086216
48	negative regulation of lipid storage (GO:0010888)	3.20961577
49	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.14163824
50	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.14009866
51	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.14009866
52	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.14009866
53	positive regulation of macroautophagy (GO:0016239)	3.13674498
54	regulation of glycogen (starch) synthase activity (GO:2000465)	3.11372342
55	uterus development (GO:0060065)	3.10382466
56	valine metabolic process (GO:0006573)	3.07674230
57	cellular protein complex localization (GO:0034629)	3.07590620
58	positive regulation of triglyceride lipase activity (GO:0061365)	3.06304314
59	positive regulation of lipoprotein lipase activity (GO:0051006)	3.06304314
60	retinal rod cell development (GO:0046548)	3.04678265
61	regulation of immunoglobulin secretion (GO:0051023)	3.01290201
62	mannosylation (GO:0097502)	3.00150173
63	regulation of establishment of cell polarity (GO:2000114)	2.98784069
64	detection of light stimulus involved in visual perception (GO:0050908)	2.98718170
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.98718170
66	negative regulation of protein oligomerization (GO:0032460)	2.97966275
67	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.97665438
68	cAMP catabolic process (GO:0006198)	2.95984187
69	regulation of memory T cell differentiation (GO:0043380)	2.94239359
70	cullin deneddylation (GO:0010388)	2.91927936
71	negative regulation of gluconeogenesis (GO:0045721)	2.90110012
72	hyaluronan catabolic process (GO:0030214)	2.88845865
73	negative regulation of heart growth (GO:0061117)	2.85035143
74	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.85035143
75	male meiosis I (GO:0007141)	2.84708279
76	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.84226350
77	regulation of protein glycosylation (GO:0060049)	2.83888286
78	regulation of hexokinase activity (GO:1903299)	2.83101588
79	regulation of glucokinase activity (GO:0033131)	2.83101588
80	positive regulation of autophagy (GO:0010508)	2.82217777
81	histone H2A acetylation (GO:0043968)	2.79893016
82	zinc ion homeostasis (GO:0055069)	2.78629757
83	omega-hydroxylase P450 pathway (GO:0097267)	2.77744300
84	inner cell mass cell proliferation (GO:0001833)	2.77238941
85	cyclic nucleotide catabolic process (GO:0009214)	2.75185848
86	positive regulation of respiratory burst (GO:0060267)	2.74794672
87	regulation of cholesterol efflux (GO:0010874)	2.74591473
88	negative regulation of systemic arterial blood pressure (GO:0003085)	2.74043029
89	regulation of cholesterol homeostasis (GO:2000188)	2.73806222
90	arginine metabolic process (GO:0006525)	2.73259694
91	regulation of glycogen metabolic process (GO:0070873)	2.72123194
92	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.72054634
93	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.71391413
94	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.69372176
95	positive regulation of glucose metabolic process (GO:0010907)	2.68806859
96	maintenance of protein location in nucleus (GO:0051457)	2.67152707
97	protein deneddylation (GO:0000338)	2.67136086
98	negative regulation of cell cycle arrest (GO:0071157)	2.66691721
99	positive regulation of actin cytoskeleton reorganization (GO:2000251)	2.64232414
100	early endosome to late endosome transport (GO:0045022)	2.64170624

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	5.12031204
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.08308143
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.05930982
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.03360899
5	BCAT_22108803_ChIP-Seq_LS180_Human	2.82072861
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.65202327
7	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.60632181
8	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.46143496
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32238955
10	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.20323752
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.11957570
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11615158
13	MYB_26560356_Chip-Seq_TH2_Human	1.98305367
14	AHR_22903824_ChIP-Seq_MCF-7_Human	1.96937896
15	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.91074895
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.90901563
17	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.88356199
18	SOX2_19829295_ChIP-Seq_ESCs_Human	1.85550084
19	NANOG_19829295_ChIP-Seq_ESCs_Human	1.85550084
20	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81805905
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.80755664
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69796572
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68541471
24	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.67194704
25	GATA1_22025678_ChIP-Seq_K562_Human	1.66627545
26	FUS_26573619_Chip-Seq_HEK293_Human	1.66486888
27	AR_20517297_ChIP-Seq_VCAP_Human	1.60308790
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53152404
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51859461
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49885588
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48586812
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48586812
33	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.45175246
34	GATA3_26560356_Chip-Seq_TH2_Human	1.44137379
35	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.43021120
36	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.42444107
37	VDR_22108803_ChIP-Seq_LS180_Human	1.40935895
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37227052
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.36905770
40	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.34358013
41	STAT3_23295773_ChIP-Seq_U87_Human	1.32602292
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.32538137
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26330042
44	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26096204
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25927168
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25337482
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.24816075
48	NCOR_22424771_ChIP-Seq_293T_Human	1.24422989
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.22860339
50	AR_25329375_ChIP-Seq_VCAP_Human	1.22579650
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22578524
52	P300_19829295_ChIP-Seq_ESCs_Human	1.20913894
53	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.19079634
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18679323
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18575066
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18129229
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.16645106
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16645106
59	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16308092
60	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.15650795
61	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.15650782
62	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.15410553
63	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12148149
64	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.11303882
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.11005038
66	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10523955
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.09611739
68	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.09138056
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08930209
70	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08661041
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07891827
72	RUNX_20019798_ChIP-Seq_JUKART_Human	1.05488878
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04597305
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.04234038
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02919132
76	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02790600
77	GBX2_23144817_ChIP-Seq_PC3_Human	1.02287184
78	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02019094
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.01787151
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01224010
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00943498
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00943498
83	GATA3_26560356_Chip-Seq_TH1_Human	1.00417491
84	TCF4_23295773_ChIP-Seq_U87_Human	0.99637262
85	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99308900
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96642035
87	MAF_26560356_Chip-Seq_TH1_Human	0.96291785
88	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94783128
89	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.94744739
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94617158
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94256241
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94068284
93	AR_19668381_ChIP-Seq_PC3_Human	0.93104823
94	GATA3_27048872_Chip-Seq_THYMUS_Human	0.91557838
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90837459
96	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.90295132
97	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.89856914
98	REST_21632747_ChIP-Seq_MESCs_Mouse	0.89674015
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89645877
100	TP53_22573176_ChIP-Seq_HFKS_Human	0.87860560

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003191_abnormal_cellular_cholesterol	4.98782951
2	MP0010368_abnormal_lymphatic_system	4.89699206
3	MP0003195_calcinosis	3.97962304
4	MP0002254_reproductive_system_inflammat	3.80178288
5	MP0000569_abnormal_digit_pigmentation	3.58175395
6	MP0002653_abnormal_ependyma_morphology	3.19216862
7	MP0003283_abnormal_digestive_organ	2.88383707
8	MP0002876_abnormal_thyroid_physiology	2.82409699
9	MP0005310_abnormal_salivary_gland	2.81043701
10	MP0009840_abnormal_foam_cell	2.79233428
11	MP0004270_analgesia	2.74667479
12	MP0008877_abnormal_DNA_methylation	2.73546906
13	MP0005058_abnormal_lysosome_morphology	2.59155322
14	MP0005647_abnormal_sex_gland	2.58726007
15	MP0002163_abnormal_gland_morphology	2.49239706
16	MP0010307_abnormal_tumor_latency	2.34284785
17	MP0002837_dystrophic_cardiac_calcinosis	2.02809079
18	MP0001346_abnormal_lacrimal_gland	1.96232507
19	MP0002090_abnormal_vision	1.89655182
20	MP0001851_eye_inflammation	1.88753587
21	MP0004185_abnormal_adipocyte_glucose	1.84688217
22	MP0001529_abnormal_vocalization	1.80838683
23	MP0009697_abnormal_copulation	1.80123163
24	MP0000427_abnormal_hair_cycle	1.76650060
25	MP0004510_myositis	1.74548131
26	MP0002396_abnormal_hematopoietic_system	1.71631864
27	MP0002295_abnormal_pulmonary_circulatio	1.65183217
28	MP0001764_abnormal_homeostasis	1.62193522
29	MP0003787_abnormal_imprinting	1.47466891
30	MP0005671_abnormal_response_to	1.45359020
31	MP0003724_increased_susceptibility_to	1.45202127
32	MP0005379_endocrine/exocrine_gland_phen	1.45200739
33	MP0010234_abnormal_vibrissa_follicle	1.42151914
34	MP0010329_abnormal_lipoprotein_level	1.40854500
35	MP0010386_abnormal_urinary_bladder	1.40178090
36	MP0002638_abnormal_pupillary_reflex	1.28216084
37	MP0005319_abnormal_enzyme/_coenzyme	1.21387611
38	MP0004885_abnormal_endolymph	1.14864891
39	MP0002168_other_aberrant_phenotype	1.09692428
40	MP0003763_abnormal_thymus_physiology	1.09206614
41	MP0005075_abnormal_melanosome_morpholog	1.09040518
42	MP0005551_abnormal_eye_electrophysiolog	1.08028945
43	MP0003567_abnormal_fetal_cardiomyocyte	1.07990052
44	MP0002009_preneoplasia	1.05481443
45	MP0002405_respiratory_system_inflammati	1.04374298
46	MP0003646_muscle_fatigue	1.03540613
47	MP0002132_abnormal_respiratory_system	1.03527066
48	MP0002928_abnormal_bile_duct	1.03317502
49	MP0009703_decreased_birth_body	1.03230660
50	MP0006072_abnormal_retinal_apoptosis	0.99518940
51	MP0004019_abnormal_vitamin_homeostasis	0.98332289
52	MP0001944_abnormal_pancreas_morphology	0.96456595
53	MP0002277_abnormal_respiratory_mucosa	0.93756273
54	MP0003075_altered_response_to	0.92049590
55	MP0005636_abnormal_mineral_homeostasis	0.91921114
56	MP0010678_abnormal_skin_adnexa	0.90040769
57	MP0002102_abnormal_ear_morphology	0.90023438
58	MP0006082_CNS_inflammation	0.87740558
59	MP0001270_distended_abdomen	0.85641842
60	MP0000383_abnormal_hair_follicle	0.84403319
61	MP0000647_abnormal_sebaceous_gland	0.83433335
62	MP0003252_abnormal_bile_duct	0.79876025
63	MP0001501_abnormal_sleep_pattern	0.79228181
64	MP0009643_abnormal_urine_homeostasis	0.78710912
65	MP0001756_abnormal_urination	0.78704161
66	MP0004924_abnormal_behavior	0.78007203
67	MP0005386_behavior/neurological_phenoty	0.78007203
68	MP0003866_abnormal_defecation	0.77256580
69	MP0000613_abnormal_salivary_gland	0.76661281
70	MP0008872_abnormal_physiological_respon	0.75968176
71	MP0001216_abnormal_epidermal_layer	0.75209548
72	MP0009672_abnormal_birth_weight	0.74281116
73	MP0001191_abnormal_skin_condition	0.74151976
74	MP0001348_abnormal_lacrimal_gland	0.73667910
75	MP0002166_altered_tumor_susceptibility	0.72793368
76	MP0000639_abnormal_adrenal_gland	0.72516657
77	MP0009046_muscle_twitch	0.72023420
78	MP0005385_cardiovascular_system_phenoty	0.71874466
79	MP0001544_abnormal_cardiovascular_syste	0.71874466
80	MP0002118_abnormal_lipid_homeostasis	0.69637685
81	MP0003959_abnormal_lean_body	0.69061298
82	MP0003303_peritoneal_inflammation	0.68993544
83	MP0008007_abnormal_cellular_replicative	0.67918868
84	MP0005253_abnormal_eye_physiology	0.66406298
85	MP0002557_abnormal_social/conspecific_i	0.66071662
86	MP0001533_abnormal_skeleton_physiology	0.63873004
87	MP0002723_abnormal_immune_serum	0.63492285
88	MP0008789_abnormal_olfactory_epithelium	0.62803661
89	MP0002419_abnormal_innate_immunity	0.59157787
90	MP0000465_gastrointestinal_hemorrhage	0.59044841
91	MP0002971_abnormal_brown_adipose	0.57946778
92	MP0008058_abnormal_DNA_repair	0.57166271
93	MP0001845_abnormal_inflammatory_respons	0.56779763
94	MP0010094_abnormal_chromosome_stability	0.56187810
95	MP0002693_abnormal_pancreas_physiology	0.56185792
96	MP0001819_abnormal_immune_cell	0.54116101
97	MP0002452_abnormal_antigen_presenting	0.54043396
98	MP0001984_abnormal_olfaction	0.53816895
99	MP0005166_decreased_susceptibility_to	0.53337783
100	MP0005025_abnormal_response_to	0.52917176

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prostate neoplasm (HP:0100787)	6.68452690
2	Abnormality of the prostate (HP:0008775)	5.06916406
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.59635436
4	Nuclear cataract (HP:0100018)	4.52578341
5	Beaking of vertebral bodies (HP:0004568)	4.21493179
6	Retinal atrophy (HP:0001105)	4.14711020
7	Hypoplasia of the thymus (HP:0000778)	4.02285337
8	Chromsome breakage (HP:0040012)	3.75254905
9	Severe visual impairment (HP:0001141)	3.50388630
10	Renal cortical cysts (HP:0000803)	3.31765553
11	Anhidrosis (HP:0000970)	3.22869966
12	Abnormality of male internal genitalia (HP:0000022)	3.22590159
13	Abnormality of macular pigmentation (HP:0008002)	3.21291326
14	Ketoacidosis (HP:0001993)	3.18212516
15	Hypochromic microcytic anemia (HP:0004840)	3.14938569
16	J-shaped sella turcica (HP:0002680)	3.14536521
17	Hypoglycemic seizures (HP:0002173)	3.13002439
18	Follicular hyperkeratosis (HP:0007502)	2.96609442
19	Spinal cord lesions (HP:0100561)	2.91547520
20	Syringomyelia (HP:0003396)	2.91547520
21	Absent frontal sinuses (HP:0002688)	2.86464269
22	Poor head control (HP:0002421)	2.84819706
23	Alopecia of scalp (HP:0002293)	2.84480304
24	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.84423542
25	Increased density of long bones (HP:0006392)	2.78896932
26	Recurrent corneal erosions (HP:0000495)	2.76602223
27	Nonimmune hydrops fetalis (HP:0001790)	2.76370772
28	Increased circulating renin level (HP:0000848)	2.76322012
29	Optic neuritis (HP:0100653)	2.74036946
30	Retrobulbar optic neuritis (HP:0100654)	2.74036946
31	Calf muscle hypertrophy (HP:0008981)	2.72330204
32	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.69971008
33	Abnormal cartilage morphology (HP:0002763)	2.67325065
34	Large for gestational age (HP:0001520)	2.67043717
35	Hyperinsulinemic hypoglycemia (HP:0000825)	2.66940304
36	Unilateral renal agenesis (HP:0000122)	2.60527432
37	Hypoglycemic coma (HP:0001325)	2.58826706
38	Abnormality of endocrine pancreas physiology (HP:0012093)	2.57413441
39	Abnormality of the pancreatic islet cells (HP:0006476)	2.57413441
40	Vascular calcification (HP:0004934)	2.57284069
41	Orchitis (HP:0100796)	2.56609312
42	Arterial thrombosis (HP:0004420)	2.55314487
43	Sex reversal (HP:0012245)	2.53360094
44	Abnormal sex determination (HP:0012244)	2.53360094
45	Abnormality of liposaccharide metabolism (HP:0010968)	2.52171443
46	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.52171443
47	Abnormality of glycolipid metabolism (HP:0010969)	2.52171443
48	Hypoplasia of the odontoid process (HP:0003311)	2.52155407
49	Keratoconjunctivitis (HP:0001096)	2.49247551
50	Zonular cataract (HP:0010920)	2.46879283
51	Agitation (HP:0000713)	2.46699643
52	Abnormality of the hip-girdle musculature (HP:0001445)	2.46573835
53	Abnormality of the musculature of the pelvis (HP:0001469)	2.46573835
54	Type I transferrin isoform profile (HP:0003642)	2.45112148
55	Poor suck (HP:0002033)	2.44890324
56	Acute lymphatic leukemia (HP:0006721)	2.42634467
57	Erythroderma (HP:0001019)	2.40953224
58	Thyroiditis (HP:0100646)	2.39998721
59	Muscle hypertrophy of the lower extremities (HP:0008968)	2.39007030
60	Abnormality of the frontal sinuses (HP:0002687)	2.37571897
61	Hyperglycemia (HP:0003074)	2.33137203
62	Rib fusion (HP:0000902)	2.29325117
63	Parakeratosis (HP:0001036)	2.28383401
64	Prominent metopic ridge (HP:0005487)	2.26637705
65	Progressive microcephaly (HP:0000253)	2.24663653
66	Cardiovascular calcification (HP:0011915)	2.20792497
67	Pendular nystagmus (HP:0012043)	2.20611430
68	Hematochezia (HP:0002573)	2.18995285
69	Polydipsia (HP:0001959)	2.17676510
70	Abnormal drinking behavior (HP:0030082)	2.17676510
71	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.16926603
72	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.16161767
73	Abnormality of eosinophils (HP:0001879)	2.13620859
74	Shoulder girdle muscle weakness (HP:0003547)	2.13445754
75	Akinesia (HP:0002304)	2.13104172
76	Pelvic girdle muscle weakness (HP:0003749)	2.12181785
77	Abnormality of dental color (HP:0011073)	2.12070205
78	Abnormality of the lumbar spine (HP:0100712)	2.11075429
79	Severe combined immunodeficiency (HP:0004430)	2.09850098
80	Dysostosis multiplex (HP:0000943)	2.09722940
81	Keratitis (HP:0000491)	2.06690159
82	Hypsarrhythmia (HP:0002521)	2.05300721
83	Lipid accumulation in hepatocytes (HP:0006561)	2.04871349
84	Irregular epiphyses (HP:0010582)	2.04371296
85	EEG with generalized epileptiform discharges (HP:0011198)	2.02348051
86	Prolonged partial thromboplastin time (HP:0003645)	2.02300911
87	Polyneuropathy (HP:0001271)	2.01941278
88	Shawl scrotum (HP:0000049)	1.99707370
89	Congenital primary aphakia (HP:0007707)	1.99653566
90	Abnormality of the metopic suture (HP:0005556)	1.98136786
91	Abnormality of the odontoid process (HP:0003310)	1.97187156
92	Myositis (HP:0100614)	1.97183667
93	Gait imbalance (HP:0002141)	1.92332870
94	Abnormal protein glycosylation (HP:0012346)	1.91891750
95	Abnormal glycosylation (HP:0012345)	1.91891750
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.91891750
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.91891750
98	Epileptiform EEG discharges (HP:0011182)	1.91875154
99	Abnormality of the renal cortex (HP:0011035)	1.91515762
100	Metatarsus adductus (HP:0001840)	1.89179210

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	IRAK4	4.65058838
2	FRK	3.71382796
3	WEE1	3.69433490
4	MAP3K4	3.49695542
5	STK16	3.44578942
6	MAP3K14	3.43482572
7	TXK	3.01107228
8	FES	2.91419747
9	MAP3K13	2.65468975
10	PASK	2.48470215
11	MATK	2.37948490
12	MAP3K7	2.19918177
13	MAP2K2	2.11377236
14	MST4	2.00281369
15	SCYL2	1.81662665
16	WNK3	1.75339282
17	MAPK13	1.74556065
18	ADRBK2	1.64861138
19	EIF2AK2	1.59616094
20	CASK	1.59611769
21	STK3	1.59318945
22	MELK	1.59033778
23	MAP4K2	1.57492050
24	PAK3	1.41806307
25	GRK6	1.37855670
26	CDK12	1.30109598
27	PLK2	1.28006801
28	PAK2	1.26094153
29	BCKDK	1.23959854
30	TAOK3	1.20408096
31	TRPM7	1.16227853
32	PKN1	1.13393754
33	CDK4	1.11710896
34	TLK1	1.08292482
35	CSNK1G1	1.06782670
36	FGFR2	1.03727833
37	IKBKB	0.98305400
38	STK38L	0.93050274
39	MAPKAPK3	0.90579627
40	MYLK	0.88549099
41	NLK	0.85606717
42	ARAF	0.82527851
43	CHUK	0.81967659
44	ERBB2	0.78682331
45	NEK9	0.78372882
46	IKBKE	0.77253285
47	CSNK1A1L	0.77038555
48	ROCK1	0.76489394
49	PIM2	0.76053197
50	CAMK1D	0.74959450
51	BCR	0.74036135
52	KIT	0.73054410
53	PRKCQ	0.69671776
54	TAOK1	0.65495270
55	MAPK3	0.60568646
56	PRKAA2	0.58600818
57	TNIK	0.57998033
58	CAMKK2	0.56783648
59	GRK1	0.56716297
60	CDK7	0.54631899
61	OXSR1	0.53925092
62	CSNK1G3	0.53668948
63	HCK	0.53480761
64	DAPK2	0.53114791
65	BRSK2	0.46105885
66	ERN1	0.42482828
67	STK39	0.41419482
68	IGF1R	0.40723205
69	TBK1	0.40449928
70	INSRR	0.40323228
71	NUAK1	0.39796593
72	DMPK	0.39625055
73	SGK2	0.39082197
74	ADRBK1	0.39064583
75	PRKCZ	0.38911935
76	PRKD1	0.38822645
77	ERBB3	0.38524844
78	DAPK1	0.38376447
79	ABL1	0.38179180
80	LYN	0.37985364
81	PRKCI	0.35983549
82	STK24	0.35788342
83	PINK1	0.35170823
84	ZAK	0.34109018
85	RPS6KA6	0.34043260
86	NTRK1	0.33917309
87	PRKCE	0.32814736
88	CSNK1D	0.32622373
89	SRPK1	0.32140213
90	GRK5	0.29968261
91	PLK3	0.29206610
92	FER	0.29133293
93	DDR2	0.29132388
94	CDK6	0.28809604
95	CDK3	0.28740354
96	PRKACA	0.28610513
97	MAPK1	0.27202108
98	CSK	0.26636019
99	MAPK4	0.26337711
100	PHKG2	0.26254093

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	5.19648661
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.05765481
3	Fatty acid elongation_Homo sapiens_hsa00062	3.47905007
4	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.55181140
5	Protein export_Homo sapiens_hsa03060	2.44208940
6	Phototransduction_Homo sapiens_hsa04744	2.11176948
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.02301283
8	Nitrogen metabolism_Homo sapiens_hsa00910	1.84069220
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.80417253
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.78450528
11	RNA polymerase_Homo sapiens_hsa03020	1.73248725
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.72104131
13	Fatty acid metabolism_Homo sapiens_hsa01212	1.69308565
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68498444
15	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.64506910
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.63716078
17	ABC transporters_Homo sapiens_hsa02010	1.61624424
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.54925566
19	Homologous recombination_Homo sapiens_hsa03440	1.45387463
20	Taste transduction_Homo sapiens_hsa04742	1.44501166
21	Peroxisome_Homo sapiens_hsa04146	1.44022652
22	Collecting duct acid secretion_Homo sapiens_hsa04966	1.43957239
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.42490867
24	Insulin resistance_Homo sapiens_hsa04931	1.40296898
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.37516404
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.33819588
27	Type II diabetes mellitus_Homo sapiens_hsa04930	1.31723606
28	Insulin secretion_Homo sapiens_hsa04911	1.31613484
29	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.31369390
30	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.28837955
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27912812
32	Lysosome_Homo sapiens_hsa04142	1.25685647
33	Fatty acid degradation_Homo sapiens_hsa00071	1.24296788
34	Butanoate metabolism_Homo sapiens_hsa00650	1.21337536
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19248356
36	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.14468504
37	Morphine addiction_Homo sapiens_hsa05032	1.13389349
38	Leishmaniasis_Homo sapiens_hsa05140	1.08264148
39	Legionellosis_Homo sapiens_hsa05134	1.06670534
40	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02188699
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.96788060
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.95588476
43	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.95004310
44	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94778568
45	Glucagon signaling pathway_Homo sapiens_hsa04922	0.91386921
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89575568
47	Malaria_Homo sapiens_hsa05144	0.89180327
48	Shigellosis_Homo sapiens_hsa05131	0.83175242
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79360180
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79342896
51	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.77923172
52	Purine metabolism_Homo sapiens_hsa00230	0.77542307
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.77095782
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.76520552
55	Other glycan degradation_Homo sapiens_hsa00511	0.75853964
56	Salivary secretion_Homo sapiens_hsa04970	0.75118900
57	Herpes simplex infection_Homo sapiens_hsa05168	0.74606578
58	Caffeine metabolism_Homo sapiens_hsa00232	0.70633123
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67798238
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67729422
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.67208798
62	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66703259
63	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63386487
64	Regulation of autophagy_Homo sapiens_hsa04140	0.61969259
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61949125
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.59285829
67	p53 signaling pathway_Homo sapiens_hsa04115	0.57433745
68	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57268587
69	Pancreatic secretion_Homo sapiens_hsa04972	0.55634337
70	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.52893106
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.49263346
72	mTOR signaling pathway_Homo sapiens_hsa04150	0.48041456
73	Insulin signaling pathway_Homo sapiens_hsa04910	0.47945505
74	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47505671
75	Thyroid cancer_Homo sapiens_hsa05216	0.45529373
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.43869638
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.43479579
78	Renin secretion_Homo sapiens_hsa04924	0.43250962
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.43049391
80	Histidine metabolism_Homo sapiens_hsa00340	0.38596485
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37779111
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37046838
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37009480
84	GABAergic synapse_Homo sapiens_hsa04727	0.33882424
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32987299
86	Salmonella infection_Homo sapiens_hsa05132	0.31099274
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.30446125
88	Amphetamine addiction_Homo sapiens_hsa05031	0.30177866
89	Gastric acid secretion_Homo sapiens_hsa04971	0.28265763
90	Complement and coagulation cascades_Homo sapiens_hsa04610	0.28131177
91	Retinol metabolism_Homo sapiens_hsa00830	0.27193336
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.26591650
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.26513425
94	Pertussis_Homo sapiens_hsa05133	0.26098357
95	Renin-angiotensin system_Homo sapiens_hsa04614	0.24233984
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23804199
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22957592
98	African trypanosomiasis_Homo sapiens_hsa05143	0.22505673
99	Mineral absorption_Homo sapiens_hsa04978	0.22433656
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.19139767

AK4P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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