AK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14804980
2mitotic metaphase plate congression (GO:0007080)4.61222303
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.58589094
4DNA replication checkpoint (GO:0000076)4.49369308
5DNA deamination (GO:0045006)4.47252964
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37557998
7ATP synthesis coupled proton transport (GO:0015986)4.37557998
8CENP-A containing nucleosome assembly (GO:0034080)4.35900191
9chromatin remodeling at centromere (GO:0031055)4.30972614
10purine nucleobase biosynthetic process (GO:0009113)4.29233192
11chaperone-mediated protein transport (GO:0072321)4.28669752
12DNA strand elongation involved in DNA replication (GO:0006271)4.24898885
13DNA double-strand break processing (GO:0000729)4.23393056
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.19494522
15telomere maintenance via semi-conservative replication (GO:0032201)4.18654195
16DNA replication initiation (GO:0006270)4.16225221
17DNA strand elongation (GO:0022616)4.06415282
18nucleobase biosynthetic process (GO:0046112)4.04421272
19mitochondrial respiratory chain complex assembly (GO:0033108)4.00994310
20metaphase plate congression (GO:0051310)4.00870482
21protein complex biogenesis (GO:0070271)4.00703966
22proteasome assembly (GO:0043248)4.00223543
23maturation of SSU-rRNA (GO:0030490)3.99287659
24ribosomal small subunit assembly (GO:0000028)3.98624544
25respiratory chain complex IV assembly (GO:0008535)3.92815074
26DNA replication-independent nucleosome organization (GO:0034724)3.89217040
27DNA replication-independent nucleosome assembly (GO:0006336)3.89217040
28telomere maintenance via recombination (GO:0000722)3.87780410
29formation of translation preinitiation complex (GO:0001731)3.84918069
30protein neddylation (GO:0045116)3.82718024
31termination of RNA polymerase III transcription (GO:0006386)3.81661092
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.81661092
33respiratory electron transport chain (GO:0022904)3.80171322
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.79655342
35ribosome biogenesis (GO:0042254)3.78332389
36NADH dehydrogenase complex assembly (GO:0010257)3.77089398
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77089398
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.77089398
39histone exchange (GO:0043486)3.77036661
40kinetochore organization (GO:0051383)3.76640514
41attachment of spindle microtubules to kinetochore (GO:0008608)3.76286560
42electron transport chain (GO:0022900)3.72629541
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71866176
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.71183526
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70278872
46rRNA modification (GO:0000154)3.68890579
477-methylguanosine mRNA capping (GO:0006370)3.67849210
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66424036
49mitotic recombination (GO:0006312)3.64651335
50spliceosomal snRNP assembly (GO:0000387)3.63249870
517-methylguanosine RNA capping (GO:0009452)3.63123628
52RNA capping (GO:0036260)3.63123628
53protein localization to kinetochore (GO:0034501)3.63100773
54kinetochore assembly (GO:0051382)3.61144022
55protein deneddylation (GO:0000338)3.60908055
56ribonucleoprotein complex biogenesis (GO:0022613)3.58757711
57cullin deneddylation (GO:0010388)3.58589658
58replication fork processing (GO:0031297)3.58141507
59cytochrome complex assembly (GO:0017004)3.56036527
60regulation of mitochondrial translation (GO:0070129)3.53578730
61establishment of chromosome localization (GO:0051303)3.50490912
62meiotic chromosome segregation (GO:0045132)3.43829257
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42995219
64transcription-coupled nucleotide-excision repair (GO:0006283)3.42181373
65piRNA metabolic process (GO:0034587)3.41148818
66ribosomal small subunit biogenesis (GO:0042274)3.39914923
67rRNA processing (GO:0006364)3.39164595
68ribosomal large subunit biogenesis (GO:0042273)3.38480281
69maturation of 5.8S rRNA (GO:0000460)3.38193355
70telomere maintenance via telomere lengthening (GO:0010833)3.38001666
71negative regulation of ligase activity (GO:0051352)3.37873278
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37873278
73protein localization to chromosome, centromeric region (GO:0071459)3.35995476
74DNA catabolic process, exonucleolytic (GO:0000738)3.34653315
75pseudouridine synthesis (GO:0001522)3.34430212
76ribosome assembly (GO:0042255)3.32970321
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31782459
78regulation of double-strand break repair via homologous recombination (GO:0010569)3.31693523
79DNA replication-dependent nucleosome organization (GO:0034723)3.31048776
80DNA replication-dependent nucleosome assembly (GO:0006335)3.31048776
81rRNA metabolic process (GO:0016072)3.29429711
82DNA damage response, detection of DNA damage (GO:0042769)3.27798631
83histone mRNA metabolic process (GO:0008334)3.24949187
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24530964
85cell cycle G1/S phase transition (GO:0044843)3.24365794
86G1/S transition of mitotic cell cycle (GO:0000082)3.24365794
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.23724324
88mitotic nuclear envelope disassembly (GO:0007077)3.23656973
89termination of RNA polymerase I transcription (GO:0006363)3.21116863
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.20347252
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.20347252
92transcription elongation from RNA polymerase I promoter (GO:0006362)3.19841198
93viral mRNA export from host cell nucleus (GO:0046784)3.19564008
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19274974
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19274974
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19274974
97negative regulation of DNA-dependent DNA replication (GO:2000104)3.18715115
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18050440
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18050440
100transcription elongation from RNA polymerase II promoter (GO:0006368)3.17720493
101positive regulation of ligase activity (GO:0051351)3.17311771
102protein targeting to mitochondrion (GO:0006626)3.15874340
103translational termination (GO:0006415)3.15318008
104viral transcription (GO:0019083)3.13771905
105spindle checkpoint (GO:0031577)3.13501925
106signal transduction involved in DNA damage checkpoint (GO:0072422)3.13109424
107signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13109424
108spliceosomal complex assembly (GO:0000245)3.12913614
109regulation of cellular amino acid metabolic process (GO:0006521)3.12409563
110water-soluble vitamin biosynthetic process (GO:0042364)3.11686665
111regulation of spindle organization (GO:0090224)3.11511356
112signal transduction involved in cell cycle checkpoint (GO:0072395)3.10030422
113rRNA methylation (GO:0031167)3.07965368
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07769658
115transcription from RNA polymerase I promoter (GO:0006360)3.07400072
116isotype switching (GO:0045190)3.07317156
117somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07317156
118somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07317156
119synaptonemal complex assembly (GO:0007130)3.06747829
120mitotic chromosome condensation (GO:0007076)3.05812216
121DNA unwinding involved in DNA replication (GO:0006268)3.04811127
122translational initiation (GO:0006413)3.04624334
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03274444
124DNA-templated transcription, elongation (GO:0006354)3.03002536
125protein localization to mitochondrion (GO:0070585)3.02575739
126peptidyl-histidine modification (GO:0018202)3.02095935
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01087692
128negative regulation of sister chromatid segregation (GO:0033046)3.01087692
129negative regulation of mitotic sister chromatid separation (GO:2000816)3.01087692
130negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01087692
131cellular component biogenesis (GO:0044085)3.00762684
132regulation of ubiquitin-protein transferase activity (GO:0051438)3.00613137
133oxidative phosphorylation (GO:0006119)3.00411194
134nuclear envelope disassembly (GO:0051081)2.98993436
135DNA ligation (GO:0006266)2.96313981
136maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96116073
137platelet dense granule organization (GO:0060155)2.94770075
138regulation of ligase activity (GO:0051340)2.94566679
139organelle disassembly (GO:1903008)2.91696245
140establishment of protein localization to mitochondrion (GO:0072655)2.91048091
141protein-cofactor linkage (GO:0018065)2.90654788
142protein K11-linked ubiquitination (GO:0070979)2.89803786
143IMP biosynthetic process (GO:0006188)2.85794936
144resolution of meiotic recombination intermediates (GO:0000712)2.85277669
145transcription from mitochondrial promoter (GO:0006390)2.84558899
146establishment of integrated proviral latency (GO:0075713)2.82956894
147mitochondrial RNA metabolic process (GO:0000959)2.82439182
148protein K6-linked ubiquitination (GO:0085020)2.82360457
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80077291
150regulation of mitotic spindle checkpoint (GO:1903504)2.80077291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04038237
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.32771862
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25409612
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.81045691
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.65438170
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56023503
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55847895
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54329577
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.43721878
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.27887442
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25475797
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20753642
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.19919165
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97521778
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88614391
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86603923
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82987985
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74316638
19VDR_23849224_ChIP-Seq_CD4+_Human2.67474225
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60906376
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46615827
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45113334
23XRN2_22483619_ChIP-Seq_HELA_Human2.38931150
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34231875
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33662444
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32139927
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24168607
28FOXP3_21729870_ChIP-Seq_TREG_Human2.21629535
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21344368
30VDR_22108803_ChIP-Seq_LS180_Human2.16155466
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15406340
32GABP_19822575_ChIP-Seq_HepG2_Human2.14609471
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14002447
34AR_21909140_ChIP-Seq_LNCAP_Human2.11364344
35ZNF274_21170338_ChIP-Seq_K562_Hela2.10569080
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03983748
37EWS_26573619_Chip-Seq_HEK293_Human2.03528076
38ELK1_19687146_ChIP-ChIP_HELA_Human2.03479858
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01643804
40MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00399098
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97242669
42TTF2_22483619_ChIP-Seq_HELA_Human1.95831033
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93958235
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92358659
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.91609839
46FUS_26573619_Chip-Seq_HEK293_Human1.91305339
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.88525560
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.86795282
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82974876
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.80618790
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77139808
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73381747
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73127944
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72644703
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.65290242
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63151537
57IGF1R_20145208_ChIP-Seq_DFB_Human1.61902565
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60644001
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57301359
60TAF15_26573619_Chip-Seq_HEK293_Human1.54221483
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53719169
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52231091
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50236338
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46586766
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45913663
66P300_19829295_ChIP-Seq_ESCs_Human1.43577745
67CIITA_25753668_ChIP-Seq_RAJI_Human1.41394055
68KDM5A_27292631_Chip-Seq_BREAST_Human1.39296330
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38712977
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36849449
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34769795
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32903992
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27671432
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27564048
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24866404
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24605929
77MYC_18940864_ChIP-ChIP_HL60_Human1.22219631
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.21450391
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20133102
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18127839
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17346521
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15681348
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15161426
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14218376
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14110341
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13158608
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12049794
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11692141
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11162847
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.10184507
91ELK1_22589737_ChIP-Seq_MCF10A_Human1.08578673
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.05697522
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05002011
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04186914
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03618542
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.02006009
97TFEB_21752829_ChIP-Seq_HELA_Human1.00218356
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99627754
99ER_23166858_ChIP-Seq_MCF-7_Human0.98334155
100TP53_22573176_ChIP-Seq_HFKS_Human0.98208839
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97142578
102SOX2_19829295_ChIP-Seq_ESCs_Human0.96706680
103NANOG_19829295_ChIP-Seq_ESCs_Human0.96706680
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95897914
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94901503
106GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92275690
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.91283565
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90632887
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90031006
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89219926
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89047506
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88935518
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88664040
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87821005
115SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87409418
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.86538876
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86409523
118SPI1_23547873_ChIP-Seq_NB4_Human0.86333599
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85699356
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85473667
121CBP_20019798_ChIP-Seq_JUKART_Human0.85473667
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.85410176
123GBX2_23144817_ChIP-Seq_PC3_Human0.85328966
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85150351
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84988628
126FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84383570
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82043497
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81774772
129FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79744929
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79111385
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76879442
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74195962
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71942417
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69974991
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67216885
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.66356513
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64922533
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64673338
139IRF1_19129219_ChIP-ChIP_H3396_Human0.63160497
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.62899481
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62301288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.11738220
2MP0010094_abnormal_chromosome_stability4.99616955
3MP0004957_abnormal_blastocyst_morpholog4.57668192
4MP0003111_abnormal_nucleus_morphology4.39737074
5MP0008877_abnormal_DNA_methylation4.28878063
6MP0008058_abnormal_DNA_repair4.17803786
7MP0003077_abnormal_cell_cycle4.12527176
8MP0008057_abnormal_DNA_replication4.08019954
9MP0008007_abnormal_cellular_replicative3.29061276
10MP0003123_paternal_imprinting2.84355770
11MP0008932_abnormal_embryonic_tissue2.81391223
12MP0003786_premature_aging2.77954115
13MP0006072_abnormal_retinal_apoptosis2.30489518
14MP0002210_abnormal_sex_determination2.26032218
15MP0002396_abnormal_hematopoietic_system2.21885589
16MP0003718_maternal_effect2.18067665
17MP0001730_embryonic_growth_arrest2.08919638
18MP0001929_abnormal_gametogenesis2.01931576
19MP0000350_abnormal_cell_proliferation1.99748059
20MP0003195_calcinosis1.94810784
21MP0005084_abnormal_gallbladder_morpholo1.93341915
22MP0003136_yellow_coat_color1.88043778
23MP0001145_abnormal_male_reproductive1.84893375
24MP0003880_abnormal_central_pattern1.84143245
25MP0002837_dystrophic_cardiac_calcinosis1.78920165
26MP0000653_abnormal_sex_gland1.69982931
27MP0002736_abnormal_nociception_after1.69766248
28MP0009333_abnormal_splenocyte_physiolog1.55910041
29MP0006292_abnormal_olfactory_placode1.55407094
30MP0004808_abnormal_hematopoietic_stem1.53791590
31MP0000490_abnormal_crypts_of1.53505694
32MP0005253_abnormal_eye_physiology1.53061336
33MP0008995_early_reproductive_senescence1.50524393
34MP0001697_abnormal_embryo_size1.48064168
35MP0010307_abnormal_tumor_latency1.44952874
36MP0000313_abnormal_cell_death1.44506864
37MP0004215_abnormal_myocardial_fiber1.44000647
38MP0005379_endocrine/exocrine_gland_phen1.43550148
39MP0003315_abnormal_perineum_morphology1.42654843
40MP0002102_abnormal_ear_morphology1.40573521
41MP0001672_abnormal_embryogenesis/_devel1.39304891
42MP0005380_embryogenesis_phenotype1.39304891
43MP0003121_genomic_imprinting1.37431210
44MP0003698_abnormal_male_reproductive1.36617218
45MP0002080_prenatal_lethality1.35314084
46MP0002160_abnormal_reproductive_system1.34483055
47MP0001984_abnormal_olfaction1.32544499
48MP0002019_abnormal_tumor_incidence1.30700546
49MP0001529_abnormal_vocalization1.28869120
50MP0003011_delayed_dark_adaptation1.28678625
51MP0009379_abnormal_foot_pigmentation1.26365701
52MP0006036_abnormal_mitochondrial_physio1.25713459
53MP0001545_abnormal_hematopoietic_system1.24979280
54MP0005397_hematopoietic_system_phenotyp1.24979280
55MP0001119_abnormal_female_reproductive1.24053116
56MP0003186_abnormal_redox_activity1.23880129
57MP0005551_abnormal_eye_electrophysiolog1.23145147
58MP0002090_abnormal_vision1.22953253
59MP0003984_embryonic_growth_retardation1.22020894
60MP0008872_abnormal_physiological_respon1.20025836
61MP0002277_abnormal_respiratory_mucosa1.18823531
62MP0001485_abnormal_pinna_reflex1.18158840
63MP0002088_abnormal_embryonic_growth/wei1.16208369
64MP0002085_abnormal_embryonic_tissue1.14559037
65MP0002132_abnormal_respiratory_system1.13442410
66MP0002254_reproductive_system_inflammat1.12546836
67MP0003567_abnormal_fetal_cardiomyocyte1.09079392
68MP0004142_abnormal_muscle_tone1.06835034
69MP0001968_abnormal_touch/_nociception1.05774446
70MP0000647_abnormal_sebaceous_gland1.04781032
71MP0005389_reproductive_system_phenotype1.03631512
72MP0005646_abnormal_pituitary_gland1.03316910
73MP0002234_abnormal_pharynx_morphology1.03004139
74MP0000631_abnormal_neuroendocrine_gland1.01920985
75MP0000516_abnormal_urinary_system1.00728699
76MP0005367_renal/urinary_system_phenotyp1.00728699
77MP0008875_abnormal_xenobiotic_pharmacok1.00619498
78MP0000358_abnormal_cell_content/0.99058795
79MP0003221_abnormal_cardiomyocyte_apopto0.99058127
80MP0005410_abnormal_fertilization0.97030404
81MP0003656_abnormal_erythrocyte_physiolo0.96972839
82MP0009697_abnormal_copulation0.96951278
83MP0002163_abnormal_gland_morphology0.95900741
84MP0002161_abnormal_fertility/fecundity0.95647070
85MP0002233_abnormal_nose_morphology0.95328580
86MP0002084_abnormal_developmental_patter0.92608637
87MP0002398_abnormal_bone_marrow0.89404501
88MP0008260_abnormal_autophagy0.88888407
89MP0003137_abnormal_impulse_conducting0.88007597
90MP0005332_abnormal_amino_acid0.87939763
91MP0006035_abnormal_mitochondrial_morpho0.87411480
92MP0005499_abnormal_olfactory_system0.86397928
93MP0005394_taste/olfaction_phenotype0.86397928
94MP0006054_spinal_hemorrhage0.86038790
95MP0000703_abnormal_thymus_morphology0.85290770
96MP0001188_hyperpigmentation0.84478395
97MP0002086_abnormal_extraembryonic_tissu0.83438255
98MP0004133_heterotaxia0.83327402
99MP0005187_abnormal_penis_morphology0.82885886
100MP0009046_muscle_twitch0.82333191
101MP0002938_white_spotting0.81899912
102MP0005636_abnormal_mineral_homeostasis0.80738574
103MP0000689_abnormal_spleen_morphology0.80724890
104MP0002095_abnormal_skin_pigmentation0.79891031
105MP0002722_abnormal_immune_system0.79365844
106MP0003941_abnormal_skin_development0.79166668
107MP0003763_abnormal_thymus_physiology0.78854901
108MP0005395_other_phenotype0.78444488
109MP0005391_vision/eye_phenotype0.77793918
110MP0001286_abnormal_eye_development0.75630723
111MP0003890_abnormal_embryonic-extraembry0.75431946
112MP0006276_abnormal_autonomic_nervous0.73556533
113MP0004197_abnormal_fetal_growth/weight/0.72231097
114MP0001293_anophthalmia0.72131780
115MP0005384_cellular_phenotype0.70862636
116MP0003646_muscle_fatigue0.70492496
117MP0001324_abnormal_eye_pigmentation0.70003449
118MP0002429_abnormal_blood_cell0.68743277
119MP0002282_abnormal_trachea_morphology0.68468108
120MP0001919_abnormal_reproductive_system0.68359871
121MP0008789_abnormal_olfactory_epithelium0.68120559
122MP0002272_abnormal_nervous_system0.67899686
123MP0005171_absent_coat_pigmentation0.67873798
124MP0005645_abnormal_hypothalamus_physiol0.67314419
125MP0003699_abnormal_female_reproductive0.66378548
126MP0005408_hypopigmentation0.64557494
127MP0003119_abnormal_digestive_system0.64245830
128MP0001764_abnormal_homeostasis0.62550810
129MP0004147_increased_porphyrin_level0.62117042
130MP0002638_abnormal_pupillary_reflex0.60261132
131MP0005075_abnormal_melanosome_morpholog0.59863028
132MP0003806_abnormal_nucleotide_metabolis0.58343414
133MP0000372_irregular_coat_pigmentation0.57060508
134MP0010352_gastrointestinal_tract_polyps0.57019404
135MP0005621_abnormal_cell_physiology0.56794542
136MP0001727_abnormal_embryo_implantation0.55430132
137MP0005266_abnormal_metabolism0.54228832
138MP0000858_altered_metastatic_potential0.53191257
139MP0000716_abnormal_immune_system0.53172922
140MP0000015_abnormal_ear_pigmentation0.52952632
141MP0002751_abnormal_autonomic_nervous0.52506844
142MP0003937_abnormal_limbs/digits/tail_de0.50972079
143MP0010030_abnormal_orbit_morphology0.50280976
144MP0009672_abnormal_birth_weight0.50221996
145MP0001853_heart_inflammation0.49450259
146MP0001986_abnormal_taste_sensitivity0.48677655
147MP0005671_abnormal_response_to0.44138836

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.34233944
2Abnormality of cells of the erythroid lineage (HP:0012130)4.30338753
3Abnormal number of erythroid precursors (HP:0012131)4.24372137
4Breast hypoplasia (HP:0003187)4.03616663
5Reticulocytopenia (HP:0001896)3.92825205
6Aplastic anemia (HP:0001915)3.83669420
7Oral leukoplakia (HP:0002745)3.75886446
8Abnormal spermatogenesis (HP:0008669)3.64954106
9Degeneration of anterior horn cells (HP:0002398)3.56324364
10Abnormality of the anterior horn cell (HP:0006802)3.56324364
11Carpal bone hypoplasia (HP:0001498)3.51610756
12Chromsome breakage (HP:0040012)3.50433553
13Patellar aplasia (HP:0006443)3.34841032
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33049221
15Cerebral edema (HP:0002181)3.23418994
16Abnormality of the preputium (HP:0100587)3.17547960
17Aplasia/Hypoplasia of the patella (HP:0006498)3.15991156
18Rough bone trabeculation (HP:0100670)3.15253186
19Cerebral hypomyelination (HP:0006808)3.12743628
20Acute necrotizing encephalopathy (HP:0006965)3.08934142
21Methylmalonic acidemia (HP:0002912)3.07538276
22Meckel diverticulum (HP:0002245)3.05261407
23Renal Fanconi syndrome (HP:0001994)3.03186343
24Abnormality of chromosome stability (HP:0003220)3.02798749
25Azoospermia (HP:0000027)3.02587345
26Abnormality of the ileum (HP:0001549)2.89932796
2711 pairs of ribs (HP:0000878)2.86243507
28Abnormal mitochondria in muscle tissue (HP:0008316)2.84751755
29Mitochondrial inheritance (HP:0001427)2.80662583
30Abnormality of midbrain morphology (HP:0002418)2.75594110
31Molar tooth sign on MRI (HP:0002419)2.75594110
32Increased CSF lactate (HP:0002490)2.73378669
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.68583396
34Microretrognathia (HP:0000308)2.68481414
35Lactic acidosis (HP:0003128)2.67925537
36Absent thumb (HP:0009777)2.66244883
37Impulsivity (HP:0100710)2.63937914
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63199457
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63199457
40Macrocytic anemia (HP:0001972)2.60670064
41Methylmalonic aciduria (HP:0012120)2.59496467
42Type I transferrin isoform profile (HP:0003642)2.58665779
43Increased hepatocellular lipid droplets (HP:0006565)2.57934484
44Increased serum lactate (HP:0002151)2.57504655
45Colon cancer (HP:0003003)2.56850805
46Respiratory failure (HP:0002878)2.55712520
47Hepatocellular necrosis (HP:0001404)2.54300763
48Pancreatic fibrosis (HP:0100732)2.53766325
49Myelodysplasia (HP:0002863)2.52693021
50Pallor (HP:0000980)2.49732363
51Congenital, generalized hypertrichosis (HP:0004540)2.49687247
52Bone marrow hypocellularity (HP:0005528)2.48362787
53Premature graying of hair (HP:0002216)2.47427811
54Selective tooth agenesis (HP:0001592)2.47420636
55Horseshoe kidney (HP:0000085)2.46893650
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46480094
57Small intestinal stenosis (HP:0012848)2.44669778
58Duodenal stenosis (HP:0100867)2.44669778
59Progressive macrocephaly (HP:0004481)2.39659321
60Leukodystrophy (HP:0002415)2.39314972
61Abnormality of glycolysis (HP:0004366)2.38101411
62Increased serum pyruvate (HP:0003542)2.38101411
63Abnormality of the labia minora (HP:0012880)2.37491985
64True hermaphroditism (HP:0010459)2.36360167
65Abnormality of methionine metabolism (HP:0010901)2.34946705
66Exertional dyspnea (HP:0002875)2.34280134
67Abnormal trabecular bone morphology (HP:0100671)2.29681839
68Optic disc pallor (HP:0000543)2.29385418
69Atrophy/Degeneration involving motor neurons (HP:0007373)2.29339409
70Secondary amenorrhea (HP:0000869)2.29101481
71Respiratory difficulties (HP:0002880)2.29070282
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28765637
73Increased intramyocellular lipid droplets (HP:0012240)2.28407457
74Type 2 muscle fiber atrophy (HP:0003554)2.26645299
75Sloping forehead (HP:0000340)2.26271223
76Acute encephalopathy (HP:0006846)2.25496809
77Lethargy (HP:0001254)2.25073529
78Irregular epiphyses (HP:0010582)2.25035452
79Intestinal atresia (HP:0011100)2.23392673
80Medial flaring of the eyebrow (HP:0010747)2.23226383
81Abnormality of the heme biosynthetic pathway (HP:0010472)2.23094692
82Renal cortical cysts (HP:0000803)2.22588181
83Lipid accumulation in hepatocytes (HP:0006561)2.21441601
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21383319
85Hyperglycinemia (HP:0002154)2.20348268
86Abnormal lung lobation (HP:0002101)2.19824405
87Hepatic necrosis (HP:0002605)2.19482704
88Muscle fiber atrophy (HP:0100295)2.19468122
89Pancreatic cysts (HP:0001737)2.19145441
90Pancytopenia (HP:0001876)2.18857163
91Nephronophthisis (HP:0000090)2.18071345
92Abnormality of serum amino acid levels (HP:0003112)2.17578499
93Cleft eyelid (HP:0000625)2.17493558
94Facial cleft (HP:0002006)2.16874823
95Abnormality of urine glucose concentration (HP:0011016)2.14928877
96Glycosuria (HP:0003076)2.14928877
97Abnormality of alanine metabolism (HP:0010916)2.14793119
98Hyperalaninemia (HP:0003348)2.14793119
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14793119
100Absent radius (HP:0003974)2.14651218
101Agnosia (HP:0010524)2.13681177
102Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13133944
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12640900
104Cellular immunodeficiency (HP:0005374)2.11008129
105Supernumerary spleens (HP:0009799)2.08363049
106Neoplasm of the pancreas (HP:0002894)2.07631488
107Multiple enchondromatosis (HP:0005701)2.07604135
108Exercise intolerance (HP:0003546)2.06158676
109Volvulus (HP:0002580)2.05383472
110Trismus (HP:0000211)2.05175193
111Short tibia (HP:0005736)2.04956761
112Hypoglycemic coma (HP:0001325)2.03202114
1133-Methylglutaconic aciduria (HP:0003535)2.02906509
114CNS hypomyelination (HP:0003429)2.01685857
115Abnormality of renal resorption (HP:0011038)2.01521115
116Triphalangeal thumb (HP:0001199)2.00984906
117Slender long bone (HP:0003100)2.00607701
118Aplasia involving forearm bones (HP:0009822)1.99348043
119Absent forearm bone (HP:0003953)1.99348043
120Medulloblastoma (HP:0002885)1.97642689
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.97342974
122Microvesicular hepatic steatosis (HP:0001414)1.96913394
123Glossoptosis (HP:0000162)1.96819337
124Premature ovarian failure (HP:0008209)1.96052522
125CNS demyelination (HP:0007305)1.95194588
126Abnormal protein glycosylation (HP:0012346)1.94610650
127Abnormal glycosylation (HP:0012345)1.94610650
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94610650
129Abnormal protein N-linked glycosylation (HP:0012347)1.94610650
130Unsteady gait (HP:0002317)1.94541573
131Reduced antithrombin III activity (HP:0001976)1.93452976
132X-linked dominant inheritance (HP:0001423)1.89355021
133Abnormality of vitamin B metabolism (HP:0004340)1.89342096
134Aplasia/hypoplasia of the uterus (HP:0008684)1.88671144
135Abnormality of the duodenum (HP:0002246)1.88473006
136Congenital primary aphakia (HP:0007707)1.82021047
137Abnormality of the renal cortex (HP:0011035)1.81140286
138Hypothermia (HP:0002045)1.80038779
139Abnormality of the vitamin B12 metabolism (HP:0004341)1.79737335
140Septo-optic dysplasia (HP:0100842)1.79014948
141Nephrogenic diabetes insipidus (HP:0009806)1.77703467
142Increased muscle lipid content (HP:0009058)1.73729480
143Abnormality of the renal medulla (HP:0100957)1.72325981
144Gait imbalance (HP:0002141)1.70899370
145Pancreatic islet-cell hyperplasia (HP:0004510)1.70121899
146Generalized aminoaciduria (HP:0002909)1.68124040
147Median cleft lip (HP:0000161)1.67479588
148Sclerocornea (HP:0000647)1.65747763
149Neoplasm of the adrenal gland (HP:0100631)1.65456564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.48631073
2WEE14.22392182
3EIF2AK13.92605194
4CDC73.73719556
5STK163.38679040
6ACVR1B3.20339302
7SRPK12.77090459
8PLK42.73656111
9BRSK22.68928757
10EIF2AK32.62993834
11MAP4K22.48679523
12WNK32.43144712
13VRK12.40406569
14VRK22.40005325
15NUAK12.39865856
16NEK22.38019573
17NME22.37988401
18CCNB12.31512465
19TRIM282.29082985
20DYRK32.09353386
21PLK11.99656997
22MKNK11.97633796
23TTK1.88484996
24FRK1.87071911
25PLK31.79137728
26NEK11.75030049
27MKNK21.73794631
28TSSK61.70293345
29BRSK11.66376438
30PNCK1.59307393
31AURKB1.57896180
32TESK21.45832353
33TNIK1.42276773
34ATR1.41804740
35PASK1.39564591
36CDK81.33659437
37CDK71.28542330
38AURKA1.28501291
39RPS6KA41.26329451
40CHEK21.26221340
41PDK31.25954798
42PDK41.25954798
43PIM21.11363666
44TESK11.10931810
45ZAK1.10144846
46BRAF1.09997259
47NME11.09809842
48BCKDK1.07303611
49EIF2AK21.04375659
50TLK10.99158182
51CHEK10.99054348
52GRK10.97873135
53SCYL20.95127603
54DYRK20.93968046
55CASK0.93537110
56MAPK130.91788084
57PBK0.91330608
58PINK10.89400025
59CSNK1G10.89274156
60STK38L0.88008925
61RPS6KB20.85010859
62ADRBK20.82589891
63CSNK1G20.82385593
64STK390.76052910
65CSNK2A10.74944483
66OXSR10.73979153
67TGFBR10.72562620
68PDK20.71814181
69MST40.71809094
70TAF10.71217469
71INSRR0.70851968
72ATM0.69235977
73CSNK1A1L0.68380971
74LIMK10.67628057
75CDK40.65062156
76CSNK2A20.64697826
77STK40.64357909
78MAPKAPK30.62664700
79BMPR1B0.62080041
80MAP3K80.61052286
81PAK10.56437005
82CDK190.54890807
83CDK20.54654859
84TEC0.53195082
85ERBB30.52367144
86MINK10.51570595
87SIK30.49756204
88WNK40.49158374
89MAP3K40.48954176
90PRKCI0.48065250
91ABL20.47922243
92PAK40.47764330
93PIM10.46729514
94CDK10.46694276
95PRKCG0.45792506
96PRKCE0.45675243
97PLK20.45633849
98DAPK10.44260176
99ARAF0.43855361
100MYLK0.43192729
101PAK30.42996864
102MUSK0.42321931
103MAP3K120.40199620
104KDR0.39927101
105RAF10.38512669
106MAP3K60.36762776
107PKN10.35535162
108CSNK1A10.35514782
109AKT30.34813095
110CSNK1E0.34429242
111ERBB40.33253590
112EPHA40.33233745
113FLT30.31932646
114MAP3K110.31663810
115RPS6KA50.31537137
116CDK30.31150882
117IRAK40.30846542
118STK240.30669272
119MAP2K70.30559838
120TIE10.30121052
121CSNK1G30.30000885
122STK100.28464228
123MELK0.28406913
124STK30.28169286
125ILK0.27928842
126YES10.27287131
127BCR0.25199832
128TAOK30.25119546
129PHKG10.24254834
130PHKG20.24254834
131MAP3K30.24087603
132IRAK30.24046833
133CAMK2A0.23972657
134BMPR20.21946279
135MARK30.21711037
136MAP3K50.20625629
137LATS20.20028776
138CLK10.18660172
139BRD40.17256975

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49462317
2Proteasome_Homo sapiens_hsa030504.21818263
3RNA polymerase_Homo sapiens_hsa030204.15083593
4* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78043367
5Mismatch repair_Homo sapiens_hsa034303.74872248
6Ribosome_Homo sapiens_hsa030103.56843304
7Spliceosome_Homo sapiens_hsa030403.21502551
8Homologous recombination_Homo sapiens_hsa034403.21017446
9RNA transport_Homo sapiens_hsa030133.02231655
10Nucleotide excision repair_Homo sapiens_hsa034202.85457364
11Pyrimidine metabolism_Homo sapiens_hsa002402.80236852
12Base excision repair_Homo sapiens_hsa034102.79450115
13Basal transcription factors_Homo sapiens_hsa030222.73199701
14Cell cycle_Homo sapiens_hsa041102.64290252
15Fanconi anemia pathway_Homo sapiens_hsa034602.29682326
16RNA degradation_Homo sapiens_hsa030182.09737589
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01359543
18Propanoate metabolism_Homo sapiens_hsa006401.98595698
19Protein export_Homo sapiens_hsa030601.88478126
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87768043
21Non-homologous end-joining_Homo sapiens_hsa034501.87360929
22One carbon pool by folate_Homo sapiens_hsa006701.70276057
23* Purine metabolism_Homo sapiens_hsa002301.66268972
24Parkinsons disease_Homo sapiens_hsa050121.55385888
25mRNA surveillance pathway_Homo sapiens_hsa030151.55186718
26Huntingtons disease_Homo sapiens_hsa050161.54414664
27Vitamin B6 metabolism_Homo sapiens_hsa007501.54100907
28Oxidative phosphorylation_Homo sapiens_hsa001901.51602857
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50002565
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47058553
31p53 signaling pathway_Homo sapiens_hsa041151.46639726
32Fatty acid elongation_Homo sapiens_hsa000621.36441448
33Steroid biosynthesis_Homo sapiens_hsa001001.35136491
34Epstein-Barr virus infection_Homo sapiens_hsa051691.25132041
35Butanoate metabolism_Homo sapiens_hsa006501.14430132
36Oocyte meiosis_Homo sapiens_hsa041141.09516148
37Peroxisome_Homo sapiens_hsa041460.92775104
38Pentose phosphate pathway_Homo sapiens_hsa000300.91435158
39Nitrogen metabolism_Homo sapiens_hsa009100.89270163
40Sulfur metabolism_Homo sapiens_hsa009200.89221213
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88190308
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88153220
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87580137
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.86560940
45Herpes simplex infection_Homo sapiens_hsa051680.83996384
46Collecting duct acid secretion_Homo sapiens_hsa049660.81283601
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80974230
48Phototransduction_Homo sapiens_hsa047440.79948878
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79392386
50Folate biosynthesis_Homo sapiens_hsa007900.78084671
51Systemic lupus erythematosus_Homo sapiens_hsa053220.76568668
52Alzheimers disease_Homo sapiens_hsa050100.76480973
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73581612
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72901667
55Tryptophan metabolism_Homo sapiens_hsa003800.72716837
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.70558257
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70182041
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.65389276
59Caffeine metabolism_Homo sapiens_hsa002320.65222037
60Antigen processing and presentation_Homo sapiens_hsa046120.63631842
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61284631
62Viral carcinogenesis_Homo sapiens_hsa052030.59494428
63Fatty acid metabolism_Homo sapiens_hsa012120.59487050
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57732614
65Fatty acid degradation_Homo sapiens_hsa000710.57618540
66beta-Alanine metabolism_Homo sapiens_hsa004100.57391681
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56638238
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56419981
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55262020
70Chemical carcinogenesis_Homo sapiens_hsa052040.54881261
71Glutathione metabolism_Homo sapiens_hsa004800.54239342
72N-Glycan biosynthesis_Homo sapiens_hsa005100.54202660
73Biosynthesis of amino acids_Homo sapiens_hsa012300.54202599
74Thyroid cancer_Homo sapiens_hsa052160.53643289
75Selenocompound metabolism_Homo sapiens_hsa004500.53300810
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51965357
77Regulation of autophagy_Homo sapiens_hsa041400.50434925
78Legionellosis_Homo sapiens_hsa051340.50276695
79Retinol metabolism_Homo sapiens_hsa008300.46467060
80Sulfur relay system_Homo sapiens_hsa041220.45112895
81HTLV-I infection_Homo sapiens_hsa051660.44701573
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44209811
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44179007
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43883665
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.39984158
86* Metabolic pathways_Homo sapiens_hsa011000.38347150
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.37568582
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37484199
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37316799
90Arginine and proline metabolism_Homo sapiens_hsa003300.36662149
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35028347
92Carbon metabolism_Homo sapiens_hsa012000.34681856
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31768440
94Alcoholism_Homo sapiens_hsa050340.31317337
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28629095
96Arachidonic acid metabolism_Homo sapiens_hsa005900.27815343
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26197864
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24619316
99Olfactory transduction_Homo sapiens_hsa047400.24269266
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23946342
101Shigellosis_Homo sapiens_hsa051310.23124678
102Primary immunodeficiency_Homo sapiens_hsa053400.22835226
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21347953
104Cardiac muscle contraction_Homo sapiens_hsa042600.19762798
105Circadian rhythm_Homo sapiens_hsa047100.19350834
106Vitamin digestion and absorption_Homo sapiens_hsa049770.19056546
107Hepatitis B_Homo sapiens_hsa051610.18856593
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18805532
109Tyrosine metabolism_Homo sapiens_hsa003500.17776144
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17630781
111Influenza A_Homo sapiens_hsa051640.17349786
112Apoptosis_Homo sapiens_hsa042100.17264679
113Fat digestion and absorption_Homo sapiens_hsa049750.17141594
114TGF-beta signaling pathway_Homo sapiens_hsa043500.17041398
115Ether lipid metabolism_Homo sapiens_hsa005650.16196469
116Measles_Homo sapiens_hsa051620.15876665
117Small cell lung cancer_Homo sapiens_hsa052220.14982398
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13742140
119Renin-angiotensin system_Homo sapiens_hsa046140.11728760
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11696951
121Pyruvate metabolism_Homo sapiens_hsa006200.10420069
122Hematopoietic cell lineage_Homo sapiens_hsa046400.09970245
123Colorectal cancer_Homo sapiens_hsa052100.09782626
124Fructose and mannose metabolism_Homo sapiens_hsa000510.09735722
125MicroRNAs in cancer_Homo sapiens_hsa052060.09329563
126Linoleic acid metabolism_Homo sapiens_hsa005910.09022518
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09001279
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.08780108
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07124154
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07056424
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.07023244
132Type I diabetes mellitus_Homo sapiens_hsa049400.06289468
133Galactose metabolism_Homo sapiens_hsa000520.06209529
134Allograft rejection_Homo sapiens_hsa053300.04604364
135HIF-1 signaling pathway_Homo sapiens_hsa040660.03126536
136Vibrio cholerae infection_Homo sapiens_hsa051100.01792220
137Asthma_Homo sapiens_hsa053100.01596846
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630-0.0160923
139Phagosome_Homo sapiens_hsa04145-0.0050994
140Graft-versus-host disease_Homo sapiens_hsa05332-0.0008725

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