AK6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.18508418
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.90021387
3translational termination (GO:0006415)6.81638657
4ATP synthesis coupled proton transport (GO:0015986)6.12984084
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.12984084
6behavioral response to nicotine (GO:0035095)6.07246958
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.79708121
8sequestering of actin monomers (GO:0042989)5.78968105
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.75077622
10cotranslational protein targeting to membrane (GO:0006613)5.73567072
11protein targeting to ER (GO:0045047)5.60170762
12translational elongation (GO:0006414)5.45023848
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.38941810
14neuron fate determination (GO:0048664)5.34535707
15cellular protein complex disassembly (GO:0043624)5.23812670
16protein localization to endoplasmic reticulum (GO:0070972)5.13486401
17regulation of protein polyubiquitination (GO:1902914)5.01757229
18viral life cycle (GO:0019058)4.95932854
19ribosomal small subunit assembly (GO:0000028)4.91637476
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83327340
21gamma-aminobutyric acid transport (GO:0015812)4.60080613
22protein complex disassembly (GO:0043241)4.39741943
23translational initiation (GO:0006413)4.33661780
24midbrain development (GO:0030901)4.30559205
25macromolecular complex disassembly (GO:0032984)4.19641231
26maturation of SSU-rRNA (GO:0030490)4.17513753
27respiratory electron transport chain (GO:0022904)3.99230539
28ribosomal small subunit biogenesis (GO:0042274)3.98755791
29electron transport chain (GO:0022900)3.95736855
30otic vesicle formation (GO:0030916)3.93689274
31inner mitochondrial membrane organization (GO:0007007)3.89429846
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87511747
33nephron epithelium morphogenesis (GO:0072088)3.80002249
34nephron tubule morphogenesis (GO:0072078)3.80002249
35limb bud formation (GO:0060174)3.79038874
36neuronal stem cell maintenance (GO:0097150)3.76695270
37protein targeting to membrane (GO:0006612)3.74649129
38somite development (GO:0061053)3.65333698
39thalamus development (GO:0021794)3.65038932
40postsynaptic membrane organization (GO:0001941)3.61765371
41lateral sprouting from an epithelium (GO:0060601)3.48178120
42organelle disassembly (GO:1903008)3.44177008
43ribosomal large subunit biogenesis (GO:0042273)3.41860883
44cAMP catabolic process (GO:0006198)3.38328299
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.34487815
46NADH dehydrogenase complex assembly (GO:0010257)3.34487815
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34487815
48presynaptic membrane assembly (GO:0097105)3.29032535
49regulation of mesenchymal cell apoptotic process (GO:2001053)3.21302877
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.17447086
51radial glial cell differentiation (GO:0060019)3.17227125
52ventricular septum development (GO:0003281)3.14333340
53mitochondrial respiratory chain complex assembly (GO:0033108)3.12294034
54positive regulation by host of viral transcription (GO:0043923)3.11316203
55protein-cofactor linkage (GO:0018065)3.11192905
56protein complex biogenesis (GO:0070271)3.10237648
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09554001
58telencephalon development (GO:0021537)3.06383031
59transmission of nerve impulse (GO:0019226)3.06132056
60positive regulation of gastrulation (GO:2000543)3.04163745
61regulation of timing of cell differentiation (GO:0048505)3.03630488
62negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.02945840
63mRNA catabolic process (GO:0006402)3.02609900
64neuron cell-cell adhesion (GO:0007158)2.99077060
65vocalization behavior (GO:0071625)2.97689340
66hematopoietic stem cell proliferation (GO:0071425)2.97125246
67signal peptide processing (GO:0006465)2.95157662
68urogenital system development (GO:0001655)2.92321598
69ATP biosynthetic process (GO:0006754)2.91824002
70hydrogen ion transmembrane transport (GO:1902600)2.91772246
71epithelial cilium movement (GO:0003351)2.89790403
72pyrimidine nucleobase catabolic process (GO:0006208)2.89441285
73cranial nerve development (GO:0021545)2.87207157
74presynaptic membrane organization (GO:0097090)2.86736606
75cyclic nucleotide catabolic process (GO:0009214)2.84522182
76regulation of gene silencing by miRNA (GO:0060964)2.84136977
77regulation of gene silencing by RNA (GO:0060966)2.84136977
78regulation of posttranscriptional gene silencing (GO:0060147)2.84136977
79negative regulation of epidermal cell differentiation (GO:0045605)2.84121892
80regulation of secondary heart field cardioblast proliferation (GO:0003266)2.82544323
81regulation of cardioblast proliferation (GO:0003264)2.82544323
82positive regulation of fatty acid beta-oxidation (GO:0032000)2.81285645
83regulation of synapse structural plasticity (GO:0051823)2.76478088
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.76435737
85urinary tract smooth muscle contraction (GO:0014848)2.75951052
86negative regulation by host of viral transcription (GO:0043922)2.75777263
87positive regulation of embryonic development (GO:0040019)2.72609973
88regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.69279652
89translation (GO:0006412)2.69044760
90tryptophan metabolic process (GO:0006568)2.68578154
91negative regulation of oligodendrocyte differentiation (GO:0048715)2.66577153
92glomerulus development (GO:0032835)2.66548254
93renal tubule morphogenesis (GO:0061333)2.65940088
94RNA catabolic process (GO:0006401)2.65577650
95positive regulation of astrocyte differentiation (GO:0048711)2.63215962
96negative regulation of epidermis development (GO:0045683)2.62693767
97regulation of development, heterochronic (GO:0040034)2.62117034
98retinal ganglion cell axon guidance (GO:0031290)2.62038481
99synaptic transmission, cholinergic (GO:0007271)2.61906853
100intracellular protein transmembrane import (GO:0044743)2.60702201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.64265481
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08107272
3ZNF274_21170338_ChIP-Seq_K562_Hela2.96872871
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87713943
5AR_21572438_ChIP-Seq_LNCaP_Human2.82840164
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76046450
7TAF15_26573619_Chip-Seq_HEK293_Human2.72487723
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.57186887
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56802598
10FUS_26573619_Chip-Seq_HEK293_Human2.47923792
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.41356531
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38697993
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36866076
14VDR_22108803_ChIP-Seq_LS180_Human2.33691312
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.33558737
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29648495
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28760209
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.26552437
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22963609
20GBX2_23144817_ChIP-Seq_PC3_Human2.18214851
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10215749
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07835420
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00362985
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.00061021
25RNF2_27304074_Chip-Seq_NSC_Mouse1.96360772
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94608611
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92077051
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78703036
29P300_19829295_ChIP-Seq_ESCs_Human1.77611321
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77565138
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76309010
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.76240204
33EWS_26573619_Chip-Seq_HEK293_Human1.72616985
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71629094
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69866490
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69241287
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68310718
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68310718
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63374434
40MYC_18940864_ChIP-ChIP_HL60_Human1.61035870
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58925781
42REST_21632747_ChIP-Seq_MESCs_Mouse1.58633654
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57634514
44IGF1R_20145208_ChIP-Seq_DFB_Human1.54465573
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.53713610
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52397744
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48139041
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48109376
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46934235
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46934235
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42572624
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.42332240
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41762255
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.40893189
55GATA1_22025678_ChIP-Seq_K562_Human1.36626439
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.36493001
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35628681
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28156460
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.26066871
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.26019920
61ER_23166858_ChIP-Seq_MCF-7_Human1.25263118
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23678769
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22163601
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.22019647
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18759426
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17819216
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17672871
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17589442
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17302098
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12624943
71BCAT_22108803_ChIP-Seq_LS180_Human1.11736410
72AR_25329375_ChIP-Seq_VCAP_Human1.11279429
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09953203
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09953203
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09953203
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09060110
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08508039
78TP53_22573176_ChIP-Seq_HFKS_Human1.08341277
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07919693
80ELK1_19687146_ChIP-ChIP_HELA_Human1.06291889
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05868980
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05529529
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04431283
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.03680255
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.02603612
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02105370
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.01786895
88NANOG_19829295_ChIP-Seq_ESCs_Human1.00983294
89SOX2_19829295_ChIP-Seq_ESCs_Human1.00983294
90SMAD4_21799915_ChIP-Seq_A2780_Human1.00807904
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99830605
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99566243
93DROSHA_22980978_ChIP-Seq_HELA_Human0.99519793
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99516142
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.99374573
96MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99048278
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97617877
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93038343
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92950449
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91551344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.50984129
2MP0003136_yellow_coat_color3.99405064
3MP0010030_abnormal_orbit_morphology3.17877644
4MP0002938_white_spotting2.85348583
5MP0005084_abnormal_gallbladder_morpholo2.81565201
6MP0006292_abnormal_olfactory_placode2.78678899
7MP0004142_abnormal_muscle_tone2.69046731
8MP0002277_abnormal_respiratory_mucosa2.42650058
9MP0002928_abnormal_bile_duct2.40262759
10MP0000631_abnormal_neuroendocrine_gland2.10445199
11MP0004133_heterotaxia1.97495913
12MP0000778_abnormal_nervous_system1.96646718
13MP0000566_synostosis1.93146610
14MP0002638_abnormal_pupillary_reflex1.92450716
15MP0004742_abnormal_vestibular_system1.91599951
16MP0001286_abnormal_eye_development1.90544101
17MP0002735_abnormal_chemical_nociception1.82711540
18MP0001485_abnormal_pinna_reflex1.74813810
19MP0003283_abnormal_digestive_organ1.73514384
20MP0002102_abnormal_ear_morphology1.70446824
21MP0003938_abnormal_ear_development1.68150561
22MP0002697_abnormal_eye_size1.66630031
23MP0003880_abnormal_central_pattern1.63596885
24MP0009745_abnormal_behavioral_response1.55264593
25MP0000026_abnormal_inner_ear1.55183608
26MP0005499_abnormal_olfactory_system1.51063545
27MP0005394_taste/olfaction_phenotype1.51063545
28MP0001529_abnormal_vocalization1.50968132
29MP0004885_abnormal_endolymph1.50527820
30MP0000383_abnormal_hair_follicle1.47113960
31MP0003011_delayed_dark_adaptation1.46831430
32MP0001440_abnormal_grooming_behavior1.45866794
33MP0002234_abnormal_pharynx_morphology1.42600099
34MP0001486_abnormal_startle_reflex1.42034488
35MP0002282_abnormal_trachea_morphology1.41003170
36MP0008789_abnormal_olfactory_epithelium1.38919974
37MP0002067_abnormal_sensory_capabilities1.32481584
38MP0000049_abnormal_middle_ear1.31780971
39MP0010386_abnormal_urinary_bladder1.30453445
40MP0003890_abnormal_embryonic-extraembry1.29352340
41MP0002822_catalepsy1.27921190
42MP0002837_dystrophic_cardiac_calcinosis1.27527533
43MP0001293_anophthalmia1.25342280
44MP0003937_abnormal_limbs/digits/tail_de1.24735361
45MP0002064_seizures1.23553231
46MP0006072_abnormal_retinal_apoptosis1.21794985
47MP0005551_abnormal_eye_electrophysiolog1.21155217
48MP0009250_abnormal_appendicular_skeleto1.20664018
49MP0001346_abnormal_lacrimal_gland1.16538900
50MP0008877_abnormal_DNA_methylation1.16526780
51MP0002751_abnormal_autonomic_nervous1.16018252
52MP0002095_abnormal_skin_pigmentation1.15410170
53MP0002233_abnormal_nose_morphology1.13753709
54MP0002653_abnormal_ependyma_morphology1.13355641
55MP0005195_abnormal_posterior_eye1.11573674
56MP0005646_abnormal_pituitary_gland1.11533328
57MP0002752_abnormal_somatic_nervous1.11051611
58MP0001968_abnormal_touch/_nociception1.08878454
59MP0002557_abnormal_social/conspecific_i1.07958938
60MP0009053_abnormal_anal_canal1.07579032
61MP0001188_hyperpigmentation1.07233059
62MP0002272_abnormal_nervous_system1.07068348
63MP0000579_abnormal_nail_morphology1.02354479
64MP0003122_maternal_imprinting1.02150892
65MP0002736_abnormal_nociception_after1.01911244
66MP0003861_abnormal_nervous_system1.00234218
67MP0000534_abnormal_ureter_morphology0.97749118
68MP0005171_absent_coat_pigmentation0.95430027
69MP0000538_abnormal_urinary_bladder0.95380653
70MP0003635_abnormal_synaptic_transmissio0.95219715
71MP0003936_abnormal_reproductive_system0.94616817
72MP0000955_abnormal_spinal_cord0.94379005
73MP0005503_abnormal_tendon_morphology0.94124336
74MP0002572_abnormal_emotion/affect_behav0.93807188
75MP0004145_abnormal_muscle_electrophysio0.92112277
76MP0008875_abnormal_xenobiotic_pharmacok0.90473619
77MP0000537_abnormal_urethra_morphology0.89779482
78MP0003638_abnormal_response/metabolism_0.89658645
79MP0005253_abnormal_eye_physiology0.88828109
80MP0001881_abnormal_mammary_gland0.88241032
81MP0002184_abnormal_innervation0.85431522
82MP0001963_abnormal_hearing_physiology0.85353550
83MP0002152_abnormal_brain_morphology0.83057786
84MP0000372_irregular_coat_pigmentation0.83002088
85MP0002063_abnormal_learning/memory/cond0.82681550
86MP0002932_abnormal_joint_morphology0.82239403
87MP0001970_abnormal_pain_threshold0.81846661
88MP0006276_abnormal_autonomic_nervous0.78998349
89MP0002882_abnormal_neuron_morphology0.77743394
90MP0005391_vision/eye_phenotype0.77121264
91MP0005187_abnormal_penis_morphology0.75975630
92MP0002160_abnormal_reproductive_system0.75442425
93MP0003942_abnormal_urinary_system0.73555749
94MP0003195_calcinosis0.72758174
95MP0003119_abnormal_digestive_system0.72607436
96MP0005085_abnormal_gallbladder_physiolo0.71787474
97MP0003878_abnormal_ear_physiology0.71059623
98MP0005377_hearing/vestibular/ear_phenot0.71059623
99MP0003959_abnormal_lean_body0.70423112
100MP0002733_abnormal_thermal_nociception0.70262980

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.42062987
2Reticulocytopenia (HP:0001896)4.29112191
3Calf muscle hypertrophy (HP:0008981)4.11778997
4Cerebellar dysplasia (HP:0007033)3.92806265
5Split foot (HP:0001839)3.77543132
6Partial duplication of the phalanx of hand (HP:0009999)3.72653140
7Muscle hypertrophy of the lower extremities (HP:0008968)3.62742062
8Congenital, generalized hypertrichosis (HP:0004540)3.48649710
9Abnormal number of erythroid precursors (HP:0012131)3.41802782
10Macrocytic anemia (HP:0001972)3.40821093
11Abnormality of cells of the erythroid lineage (HP:0012130)3.31387294
12True hermaphroditism (HP:0010459)3.29256958
13Oligodactyly (hands) (HP:0001180)3.24072329
14Partial duplication of thumb phalanx (HP:0009944)3.14770852
15Shoulder girdle muscle weakness (HP:0003547)3.08900864
16Abnormality of the pons (HP:0007361)3.02579368
17Increased hepatocellular lipid droplets (HP:0006565)2.92545185
18Concave nail (HP:0001598)2.91641747
19Pelvic girdle muscle weakness (HP:0003749)2.86981076
20Lipid accumulation in hepatocytes (HP:0006561)2.85135172
21Abnormality of the musculature of the pelvis (HP:0001469)2.83362635
22Abnormality of the hip-girdle musculature (HP:0001445)2.83362635
23Septo-optic dysplasia (HP:0100842)2.82689677
24Acute necrotizing encephalopathy (HP:0006965)2.71986332
25Abnormal sex determination (HP:0012244)2.70080771
26Sex reversal (HP:0012245)2.70080771
27Abnormal number of incisors (HP:0011064)2.68508286
283-Methylglutaconic aciduria (HP:0003535)2.66623784
29Pallor (HP:0000980)2.63826207
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.62960405
31Abnormality of the parietal bone (HP:0002696)2.62261197
32Limb dystonia (HP:0002451)2.59579475
33Long nose (HP:0003189)2.58779228
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56940629
35Hypoplasia of the pons (HP:0012110)2.56684221
36Pancreatic cysts (HP:0001737)2.55950773
37Decreased circulating renin level (HP:0003351)2.45362376
38Nephronophthisis (HP:0000090)2.39717334
39Bilateral microphthalmos (HP:0007633)2.37135737
40Limb-girdle muscle atrophy (HP:0003797)2.34581134
41Abnormal ciliary motility (HP:0012262)2.31026680
42Humeroradial synostosis (HP:0003041)2.29734988
43Synostosis involving the elbow (HP:0003938)2.29734988
44Abnormal respiratory epithelium morphology (HP:0012253)2.28644025
45Abnormal respiratory motile cilium morphology (HP:0005938)2.28644025
46Mitochondrial inheritance (HP:0001427)2.26730770
47Vertebral fusion (HP:0002948)2.26232247
48Abnormality of the labia minora (HP:0012880)2.24678006
49Duplication of thumb phalanx (HP:0009942)2.23849815
50Abnormal mitochondria in muscle tissue (HP:0008316)2.19276665
51Birth length less than 3rd percentile (HP:0003561)2.18130280
52Pancreatic fibrosis (HP:0100732)2.16483384
53Prominent supraorbital ridges (HP:0000336)2.14985230
54Maternal diabetes (HP:0009800)2.13219999
55Absent septum pellucidum (HP:0001331)2.12358261
56Morphological abnormality of the inner ear (HP:0011390)2.10928222
57Neoplasm of head and neck (HP:0012288)2.10780321
58Esophageal neoplasm (HP:0100751)2.10780321
59Progressive macrocephaly (HP:0004481)2.10385272
60Exertional dyspnea (HP:0002875)2.09513968
61Lissencephaly (HP:0001339)2.04812569
62Abnormality of the pubic bones (HP:0003172)2.04759678
63Acute encephalopathy (HP:0006846)2.02300774
64Abnormality of the renal medulla (HP:0100957)2.00809826
65Oligodactyly (HP:0012165)1.99924743
66Triphalangeal thumb (HP:0001199)1.98731709
67Hypoplasia of the radius (HP:0002984)1.96763968
6811 pairs of ribs (HP:0000878)1.94885463
69Duplicated collecting system (HP:0000081)1.94431972
70Increased CSF lactate (HP:0002490)1.93700193
71Molar tooth sign on MRI (HP:0002419)1.93366183
72Abnormality of midbrain morphology (HP:0002418)1.93366183
73Thyroid-stimulating hormone excess (HP:0002925)1.91373425
74Hyperactive renin-angiotensin system (HP:0000841)1.90116434
75Abnormality of the 2nd finger (HP:0004100)1.89295971
76Renal Fanconi syndrome (HP:0001994)1.88613919
77Medial flaring of the eyebrow (HP:0010747)1.87655418
78Frequent falls (HP:0002359)1.87155988
79Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.86657160
80Short hallux (HP:0010109)1.86401538
81Difficulty climbing stairs (HP:0003551)1.83801416
82Increased corneal curvature (HP:0100692)1.82228761
83Keratoconus (HP:0000563)1.82228761
84Esophageal atresia (HP:0002032)1.80697626
85Scrotal hypoplasia (HP:0000046)1.77057951
86Abnormality of the renal collecting system (HP:0004742)1.75356793
87Meningocele (HP:0002435)1.74986321
88Hemivertebrae (HP:0002937)1.74085349
89Patellar aplasia (HP:0006443)1.71267129
90Optic disc pallor (HP:0000543)1.69997107
91Abnormality of the calf musculature (HP:0001430)1.69732461
92Hypothermia (HP:0002045)1.69165482
93Hypoplastic labia majora (HP:0000059)1.68495548
94Abnormality of the vitreous humor (HP:0004327)1.66604667
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66023676
96Aplasia/Hypoplasia of the hallux (HP:0008362)1.65506764
97Nasolacrimal duct obstruction (HP:0000579)1.64855583
98Abnormal respiratory motile cilium physiology (HP:0012261)1.64702974
99Hypoplastic pelvis (HP:0008839)1.64663425
100Abnormality of the middle phalanges of the toes (HP:0010183)1.63775460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.36784440
2PNCK5.36578061
3TSSK63.04521079
4VRK12.92140827
5WEE12.74724108
6NTRK32.73750903
7TAF12.22700710
8TAOK32.22070421
9MARK12.21037694
10CASK2.11636830
11PASK2.03214787
12MAP3K121.99279129
13EPHA41.98265394
14TGFBR11.84063285
15WNK31.84007277
16TYRO31.74485604
17MKNK21.65588465
18WNK41.59628581
19BMPR1B1.58803110
20TNIK1.55623265
21ADRBK21.55423489
22DYRK21.54206481
23MKNK11.54075117
24ZAK1.53889502
25NME11.43977428
26INSRR1.35299580
27MAP3K21.34328588
28VRK21.28317893
29MAPK131.28010781
30TLK11.23441958
31PAK31.16088569
32STK161.14714027
33PLK31.14570022
34MAPKAPK51.06961598
35NTRK21.05892915
36UHMK11.04480284
37EPHB21.02714658
38CDK30.96470045
39PRKCG0.94667870
40TRIM280.92147835
41CDC70.83766887
42ADRBK10.76431885
43MAP3K40.73752224
44FGFR20.71626575
45MUSK0.70519240
46NUAK10.69372702
47CDK190.68338177
48OXSR10.66709505
49DYRK1A0.64792751
50PAK20.62737380
51PKN10.62701917
52BCKDK0.60238770
53DMPK0.58603911
54STK240.54190410
55PTK60.52895737
56MAP2K40.51825650
57AKT20.51754948
58STK110.50415628
59STK390.50373661
60YES10.46422928
61PHKG20.45762770
62PHKG10.45762770
63RPS6KA50.45043215
64PRKACB0.39814344
65STK38L0.39531977
66MAP2K70.38775981
67PRKACA0.37916316
68KSR10.37467650
69DYRK1B0.37371486
70OBSCN0.36307908
71PRKG10.36233149
72GRK10.36110791
73CSNK2A20.36106800
74MAP2K10.35344218
75MAP2K20.33872070
76MAP2K60.33758127
77FGR0.33497736
78RPS6KA60.33296919
79PRKCE0.32054427
80CDK80.30535315
81CSNK2A10.29943592
82CSNK1E0.29904927
83MAPK40.29814165
84PDGFRB0.29593174
85NEK20.28675388
86CAMK1D0.28006728
87MATK0.27526786
88DDR20.27468123
89CHEK20.27446200
90GSK3A0.27411046
91KIT0.25530772
92MAPK140.23893873
93CAMK2A0.23360399
94EPHA20.22711052
95GRK70.21684852
96PRKG20.21504875
97AKT10.20571168
98RPS6KA10.20389370
99ERBB20.19884262
100PINK10.19696861

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.02467697
2Oxidative phosphorylation_Homo sapiens_hsa001904.66504208
3Parkinsons disease_Homo sapiens_hsa050124.04356674
4Nitrogen metabolism_Homo sapiens_hsa009102.93070162
5Cardiac muscle contraction_Homo sapiens_hsa042602.92435320
6Huntingtons disease_Homo sapiens_hsa050162.88664834
7Alzheimers disease_Homo sapiens_hsa050102.85906994
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56561655
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.46415127
10Protein export_Homo sapiens_hsa030602.12130251
11Basal cell carcinoma_Homo sapiens_hsa052172.06609206
12Caffeine metabolism_Homo sapiens_hsa002321.81055384
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80936322
14Nicotine addiction_Homo sapiens_hsa050331.77082794
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72604713
16Hedgehog signaling pathway_Homo sapiens_hsa043401.71730383
17Taste transduction_Homo sapiens_hsa047421.71467856
18Linoleic acid metabolism_Homo sapiens_hsa005911.69241870
19Phototransduction_Homo sapiens_hsa047441.65836468
20RNA polymerase_Homo sapiens_hsa030201.62115347
21Homologous recombination_Homo sapiens_hsa034401.61409507
22Tryptophan metabolism_Homo sapiens_hsa003801.58448902
23Cocaine addiction_Homo sapiens_hsa050301.39810347
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39125183
25Butanoate metabolism_Homo sapiens_hsa006501.32907793
26Morphine addiction_Homo sapiens_hsa050321.32777260
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28936628
28Basal transcription factors_Homo sapiens_hsa030221.28882077
29Folate biosynthesis_Homo sapiens_hsa007901.27458160
30Proteasome_Homo sapiens_hsa030501.26709740
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16191317
32Fanconi anemia pathway_Homo sapiens_hsa034601.00661707
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96136359
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94877389
35Primary bile acid biosynthesis_Homo sapiens_hsa001200.94618456
36Glutamatergic synapse_Homo sapiens_hsa047240.93460541
37GABAergic synapse_Homo sapiens_hsa047270.88970264
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80604406
39Chemical carcinogenesis_Homo sapiens_hsa052040.73906727
40Insulin secretion_Homo sapiens_hsa049110.73825932
41Spliceosome_Homo sapiens_hsa030400.73511644
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71673113
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70589195
44RNA degradation_Homo sapiens_hsa030180.69588092
45Serotonergic synapse_Homo sapiens_hsa047260.69442915
46Vitamin digestion and absorption_Homo sapiens_hsa049770.68352996
47Amphetamine addiction_Homo sapiens_hsa050310.67803419
48Cholinergic synapse_Homo sapiens_hsa047250.67107965
49TGF-beta signaling pathway_Homo sapiens_hsa043500.66306237
50Sulfur relay system_Homo sapiens_hsa041220.64839169
51Selenocompound metabolism_Homo sapiens_hsa004500.64103382
52Histidine metabolism_Homo sapiens_hsa003400.63900564
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63259639
54Axon guidance_Homo sapiens_hsa043600.62151293
55Circadian entrainment_Homo sapiens_hsa047130.60691548
56Olfactory transduction_Homo sapiens_hsa047400.59377315
57Ether lipid metabolism_Homo sapiens_hsa005650.59354090
58Wnt signaling pathway_Homo sapiens_hsa043100.58911113
59Melanogenesis_Homo sapiens_hsa049160.57585864
60Purine metabolism_Homo sapiens_hsa002300.55463973
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55232383
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51375347
63Hippo signaling pathway_Homo sapiens_hsa043900.49907788
64Arachidonic acid metabolism_Homo sapiens_hsa005900.49550290
65Mismatch repair_Homo sapiens_hsa034300.48372185
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46355565
67Glycerolipid metabolism_Homo sapiens_hsa005610.43898341
68cAMP signaling pathway_Homo sapiens_hsa040240.42104136
69Pyruvate metabolism_Homo sapiens_hsa006200.41225529
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40555797
71Fat digestion and absorption_Homo sapiens_hsa049750.40424435
72Bile secretion_Homo sapiens_hsa049760.39721967
73Mineral absorption_Homo sapiens_hsa049780.38333046
74Calcium signaling pathway_Homo sapiens_hsa040200.38039674
75Nucleotide excision repair_Homo sapiens_hsa034200.37098583
76Peroxisome_Homo sapiens_hsa041460.36955225
77Metabolic pathways_Homo sapiens_hsa011000.35575256
78Ovarian steroidogenesis_Homo sapiens_hsa049130.35497886
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.35202826
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34966664
81Pathways in cancer_Homo sapiens_hsa052000.34329080
82Dopaminergic synapse_Homo sapiens_hsa047280.32940586
83Alcoholism_Homo sapiens_hsa050340.31794784
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31319256
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31082784
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.30722367
87Oxytocin signaling pathway_Homo sapiens_hsa049210.29380915
88Collecting duct acid secretion_Homo sapiens_hsa049660.28277451
89Retinol metabolism_Homo sapiens_hsa008300.27970518
90MAPK signaling pathway_Homo sapiens_hsa040100.27355801
91Gap junction_Homo sapiens_hsa045400.24662111
92Estrogen signaling pathway_Homo sapiens_hsa049150.24520434
93Arginine and proline metabolism_Homo sapiens_hsa003300.23346729
94Regulation of autophagy_Homo sapiens_hsa041400.23093319
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22502240
96Long-term depression_Homo sapiens_hsa047300.22484428
97Gastric acid secretion_Homo sapiens_hsa049710.21905738
98DNA replication_Homo sapiens_hsa030300.21520806
99RNA transport_Homo sapiens_hsa030130.21215966
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21049865

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »