AK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* epithelial cilium movement (GO:0003351)9.29251528
2GTP biosynthetic process (GO:0006183)7.97364059
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.85237960
4motile cilium assembly (GO:0044458)7.72620497
5* axoneme assembly (GO:0035082)7.63228167
6UTP biosynthetic process (GO:0006228)7.37289717
7ventricular system development (GO:0021591)7.08186392
8UTP metabolic process (GO:0046051)6.64969348
9* nucleoside diphosphate phosphorylation (GO:0006165)6.62707297
10guanosine-containing compound biosynthetic process (GO:1901070)6.40588543
11piRNA metabolic process (GO:0034587)6.17143550
12sperm motility (GO:0030317)6.13818897
13fusion of sperm to egg plasma membrane (GO:0007342)6.11493372
14regulation of cilium movement (GO:0003352)5.94459353
15left/right pattern formation (GO:0060972)5.92799450
16male meiosis I (GO:0007141)5.64413254
17spermatid development (GO:0007286)5.39950199
18sperm-egg recognition (GO:0035036)5.38902614
19multicellular organism reproduction (GO:0032504)5.32267288
20synaptonemal complex organization (GO:0070193)5.26212241
21CTP metabolic process (GO:0046036)5.21323227
22CTP biosynthetic process (GO:0006241)5.21323227
23binding of sperm to zona pellucida (GO:0007339)5.19679376
24meiosis I (GO:0007127)5.09173739
25spindle assembly involved in mitosis (GO:0090307)5.06797858
26left/right axis specification (GO:0070986)5.02239561
27pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.95671431
28cell-cell recognition (GO:0009988)4.80432254
29synaptonemal complex assembly (GO:0007130)4.80230798
30male meiosis (GO:0007140)4.79481562
31primary alcohol catabolic process (GO:0034310)4.64491027
32pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.56532298
33plasma membrane fusion (GO:0045026)4.56315406
34negative regulation of inclusion body assembly (GO:0090084)4.52399358
35pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.51695664
36protein localization to cilium (GO:0061512)4.48177747
37vitamin transmembrane transport (GO:0035461)4.36393077
38reproduction (GO:0000003)4.24143272
39meiotic cell cycle (GO:0051321)4.18824478
40DNA methylation involved in gamete generation (GO:0043046)4.17618098
41cell wall macromolecule catabolic process (GO:0016998)4.13206540
42cell wall macromolecule metabolic process (GO:0044036)4.13206540
43acrosome assembly (GO:0001675)4.09437482
44single fertilization (GO:0007338)4.07983455
45* microtubule bundle formation (GO:0001578)4.02905609
46acrosome reaction (GO:0007340)4.02061065
47pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.00373109
48regulation of inclusion body assembly (GO:0090083)3.99945839
49diterpenoid biosynthetic process (GO:0016102)3.99718580
50cilium organization (GO:0044782)3.94472566
51centriole replication (GO:0007099)3.93406561
52* nucleotide phosphorylation (GO:0046939)3.89280362
53negative regulation of T cell differentiation in thymus (GO:0033085)3.87193712
54meiotic nuclear division (GO:0007126)3.86827915
55ethanol metabolic process (GO:0006067)3.83009508
56* microtubule-based movement (GO:0007018)3.77165632
57centriole assembly (GO:0098534)3.76996572
58intraciliary transport (GO:0042073)3.75507327
59microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.72402062
60chaperone-mediated protein complex assembly (GO:0051131)3.68397724
61fertilization (GO:0009566)3.63562062
62regulation of microtubule-based movement (GO:0060632)3.63185325
63exogenous drug catabolic process (GO:0042738)3.62900978
64cilium assembly (GO:0042384)3.62645977
65negative regulation of fibroblast apoptotic process (GO:2000270)3.62040750
66* cell projection assembly (GO:0030031)3.61937949
67biotin metabolic process (GO:0006768)3.60923629
68response to xenobiotic stimulus (GO:0009410)3.59692371
69* spermatogenesis (GO:0007283)3.55541217
70* male gamete generation (GO:0048232)3.55034377
71keratinocyte development (GO:0003334)3.53476182
72nonmotile primary cilium assembly (GO:0035058)3.51061439
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.45276764
74microtubule depolymerization (GO:0007019)3.34120441
75lung epithelium development (GO:0060428)3.33370929
76retinoic acid metabolic process (GO:0042573)3.31858584
77pyrimidine-containing compound transmembrane transport (GO:0072531)3.31030453
78* gamete generation (GO:0007276)3.30818616
79mitotic metaphase plate congression (GO:0007080)3.29695388
80ribosome assembly (GO:0042255)3.29560064
81* nucleoside diphosphate metabolic process (GO:0009132)3.27774533
82chromosome organization involved in meiosis (GO:0070192)3.24764088
83terpenoid biosynthetic process (GO:0016114)3.24617924
84determination of left/right symmetry (GO:0007368)3.21334088
85photoreceptor cell maintenance (GO:0045494)3.21053890
86L-fucose catabolic process (GO:0042355)3.18329543
87fucose catabolic process (GO:0019317)3.18329543
88L-fucose metabolic process (GO:0042354)3.18329543
89pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.18000632
90smoothened signaling pathway (GO:0007224)3.16168765
91protein refolding (GO:0042026)3.12754222
92* cellular component assembly involved in morphogenesis (GO:0010927)3.09104877
93interferon-gamma secretion (GO:0072643)3.07741879
94determination of bilateral symmetry (GO:0009855)3.05985918
95cornea development in camera-type eye (GO:0061303)3.04486859
96blastocyst development (GO:0001824)3.03994276
97aldehyde catabolic process (GO:0046185)3.03837135
98drug catabolic process (GO:0042737)3.02040748
99germ cell development (GO:0007281)3.01595264
100one-carbon compound transport (GO:0019755)3.00772913
101pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.99509724
102establishment of monopolar cell polarity (GO:0061162)2.98744297
103establishment or maintenance of monopolar cell polarity (GO:0061339)2.98744297
104protein polyglutamylation (GO:0018095)2.98593900
105microtubule severing (GO:0051013)2.97228350
106specification of symmetry (GO:0009799)2.96659396
107pyrimidine nucleotide biosynthetic process (GO:0006221)2.93417959
108cilium morphogenesis (GO:0060271)2.92995502
109ethanol oxidation (GO:0006069)2.90839323
110establishment of apical/basal cell polarity (GO:0035089)2.88687726
111deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.88613508
112sperm capacitation (GO:0048240)2.88582289
113regulation of centriole replication (GO:0046599)2.88452265
114folic acid transport (GO:0015884)2.87760758
115water-soluble vitamin biosynthetic process (GO:0042364)2.87148397
116regulation of meiosis I (GO:0060631)2.85169821
117retinol metabolic process (GO:0042572)2.84682926
118meiotic cell cycle process (GO:1903046)2.83847262
119cellular ketone body metabolic process (GO:0046950)2.82801989
120otic vesicle formation (GO:0030916)2.80118970
121proteasome assembly (GO:0043248)2.78835174
122rRNA catabolic process (GO:0016075)2.76854337
123microtubule polymerization or depolymerization (GO:0031109)2.75838900
124regulation of interleukin-5 production (GO:0032674)2.75003728
125cytoplasmic microtubule organization (GO:0031122)2.74455980
126regulation of centrosome cycle (GO:0046605)2.72541773
127glutathione derivative biosynthetic process (GO:1901687)2.72484104
128glutathione derivative metabolic process (GO:1901685)2.72484104
129lateral ventricle development (GO:0021670)2.72401240
130cellular process involved in reproduction in multicellular organism (GO:0022412)2.69366509
131spinal cord motor neuron differentiation (GO:0021522)2.67222356
132regulation of spindle organization (GO:0090224)2.66064490
133regulation of glucokinase activity (GO:0033131)2.65760686
134regulation of hexokinase activity (GO:1903299)2.65760686
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65671306
136negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65467193
137negative regulation of B cell mediated immunity (GO:0002713)2.65467193
138organic cation transport (GO:0015695)2.61730286
139tolerance induction (GO:0002507)2.60574976
140labyrinthine layer development (GO:0060711)2.60328361
141pyrimidine ribonucleotide metabolic process (GO:0009218)2.60237898
142glomerular epithelial cell development (GO:0072310)2.59968509
143intra-S DNA damage checkpoint (GO:0031573)2.59503019
144* multicellular organismal reproductive process (GO:0048609)2.56710006
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56282560
146ketone body metabolic process (GO:1902224)2.55709477
147pyrimidine nucleoside biosynthetic process (GO:0046134)2.55422816
148ADP metabolic process (GO:0046031)2.55308623
149behavioral response to nicotine (GO:0035095)2.52415757
150regulation of germinal center formation (GO:0002634)2.50685486
151neural tube formation (GO:0001841)2.47436365
152primary alcohol metabolic process (GO:0034308)2.46794909
153neurotransmitter metabolic process (GO:0042133)2.44615750
154limb development (GO:0060173)2.44434195
155appendage development (GO:0048736)2.44434195
156calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.43512923
157preassembly of GPI anchor in ER membrane (GO:0016254)2.41574829
158retinal cone cell development (GO:0046549)2.41045328
159organelle assembly (GO:0070925)2.37629801
160benzene-containing compound metabolic process (GO:0042537)2.36846663
161phosphatidylcholine biosynthetic process (GO:0006656)2.33962055
162lateral sprouting from an epithelium (GO:0060601)2.33167567
163cysteine metabolic process (GO:0006534)2.31322871
164platelet dense granule organization (GO:0060155)2.30487504
165regulation of collateral sprouting (GO:0048670)2.30273167
166thyroid hormone metabolic process (GO:0042403)2.28328824
167GPI anchor metabolic process (GO:0006505)2.28198562
168positive regulation of oligodendrocyte differentiation (GO:0048714)2.27206990
169cilium or flagellum-dependent cell motility (GO:0001539)13.6848678
170axonemal dynein complex assembly (GO:0070286)12.0850756
171* cilium movement (GO:0003341)11.9053342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.01361038
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.22562837
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.79362049
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.28372914
5VDR_22108803_ChIP-Seq_LS180_Human3.18890622
6ZNF274_21170338_ChIP-Seq_K562_Hela3.15036746
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81029462
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.80863789
9KAP1_22055183_ChIP-Seq_ESCs_Mouse2.47733560
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42344252
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.40128620
12GBX2_23144817_ChIP-Seq_PC3_Human2.29063011
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.19134864
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17243423
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13956999
16E2F7_22180533_ChIP-Seq_HELA_Human2.01391504
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01224428
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.00588759
19IGF1R_20145208_ChIP-Seq_DFB_Human1.98319992
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97875663
21MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96845131
22EZH2_22144423_ChIP-Seq_EOC_Human1.95140295
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94852328
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94173008
25AR_21909140_ChIP-Seq_LNCAP_Human1.93892874
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.92892032
27ER_23166858_ChIP-Seq_MCF-7_Human1.91926774
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89779777
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88794887
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.85698748
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83503924
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79460493
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.77050917
34TAF15_26573619_Chip-Seq_HEK293_Human1.74458610
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72505407
36FUS_26573619_Chip-Seq_HEK293_Human1.72129524
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.71075380
38DROSHA_22980978_ChIP-Seq_HELA_Human1.68784682
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67348053
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67348053
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67348053
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.66989377
43EWS_26573619_Chip-Seq_HEK293_Human1.65989426
44* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.64208929
45P300_19829295_ChIP-Seq_ESCs_Human1.64161880
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61955915
47BCAT_22108803_ChIP-Seq_LS180_Human1.61900193
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58320234
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.56846274
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55901204
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53818226
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53567567
53SMAD4_21799915_ChIP-Seq_A2780_Human1.53251030
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49186297
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48644404
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47841672
57* STAT3_23295773_ChIP-Seq_U87_Human1.47839915
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46333381
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45273539
60STAT1_17558387_ChIP-Seq_HELA_Human1.44085360
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.43582891
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43377636
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43230394
64TCF4_22108803_ChIP-Seq_LS180_Human1.43108743
65AR_25329375_ChIP-Seq_VCAP_Human1.42028522
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40523985
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.40043175
68TCF4_23295773_ChIP-Seq_U87_Human1.39004806
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38822017
70AHR_22903824_ChIP-Seq_MCF-7_Human1.38299455
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.37260461
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36876116
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34309335
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34197633
75CBP_20019798_ChIP-Seq_JUKART_Human1.33294100
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33294100
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32962951
78* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32789453
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32581373
80AR_20517297_ChIP-Seq_VCAP_Human1.32381357
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29497740
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28739370
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.27561231
84SOX2_19829295_ChIP-Seq_ESCs_Human1.27397002
85NANOG_19829295_ChIP-Seq_ESCs_Human1.27397002
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26558445
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26308171
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24952576
89NCOR_22424771_ChIP-Seq_293T_Human1.24094260
90TP53_22573176_ChIP-Seq_HFKS_Human1.23968423
91RUNX2_22187159_ChIP-Seq_PCA_Human1.22174866
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.19899807
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.19608752
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19241450
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19126358
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19126358
97REST_21632747_ChIP-Seq_MESCs_Mouse1.18988925
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18828086
99MYC_18555785_ChIP-Seq_MESCs_Mouse1.18229573
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17743491
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17631597
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16119241
103RNF2_27304074_Chip-Seq_NSC_Mouse1.16082355
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15826452
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15823100
106ETV1_20927104_ChIP-Seq_GIST48_Human1.15412511
107CDX2_22108803_ChIP-Seq_LS180_Human1.15004507
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13088422
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12953410
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11418545
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10752584
112HOXB7_26014856_ChIP-Seq_BT474_Human1.10731953
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10091404
114ERG_20517297_ChIP-Seq_VCAP_Human1.09889424
115PHF8_20622853_ChIP-Seq_HELA_Human1.09333102
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09146876
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07598050
118PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07202981
119MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05903652
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05778958
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05694588
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.05693678
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05265471
124ZNF263_19887448_ChIP-Seq_K562_Human1.04600438
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03688050
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.03687221
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03290450
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03240075
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.03220683
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03137939
131MYC_19829295_ChIP-Seq_ESCs_Human1.02864707
132NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02826150
133CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02712972
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02215893
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01306993
136KAP1_27257070_Chip-Seq_ESCs_Mouse1.01230489
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00592139
138FOXA1_25552417_ChIP-Seq_VCAP_Human1.00147171
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99940481
140POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99660998
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.99652327
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.99370235
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99110433
144TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98441238
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98173590
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98065121
147STAT1_20625510_ChIP-Seq_HELA_Human0.97951342
148TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97092329
149TBL1_22424771_ChIP-Seq_293T_Human0.97032621
150SMRT_27268052_Chip-Seq_Bcells_Human0.96737410
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.96614042
152IRF1_19129219_ChIP-ChIP_H3396_Human0.96025584
153GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.94852396
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92755536
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92736071
156SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92530058
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92027676
158NANOG_21062744_ChIP-ChIP_HESCs_Human0.91506490
159TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90797160
160POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90659025
161* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90101896
162EST1_17652178_ChIP-ChIP_JURKAT_Human0.89135645
163RBPJ_21746931_ChIP-Seq_IB4_Human0.88580226
164SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88516925
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88128059
166GABP_17652178_ChIP-ChIP_JURKAT_Human0.88068773
167FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87761991
168HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87590461
169TP63_19390658_ChIP-ChIP_HaCaT_Human0.86677073
170SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85849085
171GATA3_21867929_ChIP-Seq_TH1_Mouse0.85598453
172TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85437675
173PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85362156
174EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84460137
175NANOG_16518401_ChIP-PET_MESCs_Mouse0.83655225
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83265307
177AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82606474
178NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82175712
179FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81774807
180FOXA1_25329375_ChIP-Seq_VCAP_Human0.81774807
181KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81536005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.56469766
2MP0002653_abnormal_ependyma_morphology5.08888788
3MP0008875_abnormal_xenobiotic_pharmacok4.51776323
4MP0003136_yellow_coat_color4.20350641
5MP0001929_abnormal_gametogenesis3.60964124
6MP0003718_maternal_effect3.54747536
7MP0003698_abnormal_male_reproductive3.52480246
8MP0001984_abnormal_olfaction3.09969451
9MP0004043_abnormal_pH_regulation2.98684049
10MP0003693_abnormal_embryo_hatching2.94682606
11MP0002210_abnormal_sex_determination2.86743844
12MP0003111_abnormal_nucleus_morphology2.60098046
13MP0009780_abnormal_chondrocyte_physiolo2.57958468
14MP0008877_abnormal_DNA_methylation2.54968542
15MP0005623_abnormal_meninges_morphology2.51715394
16MP0005670_abnormal_white_adipose2.46375592
17MP0009840_abnormal_foam_cell2.46328823
18MP0005645_abnormal_hypothalamus_physiol2.45677530
19MP0008057_abnormal_DNA_replication2.43739657
20MP0003195_calcinosis2.43042149
21MP0001145_abnormal_male_reproductive2.42735027
22MP0005075_abnormal_melanosome_morpholog2.32626283
23MP0004019_abnormal_vitamin_homeostasis2.30705130
24MP0004381_abnormal_hair_follicle2.29880728
25MP0004957_abnormal_blastocyst_morpholog2.28940085
26MP0003315_abnormal_perineum_morphology2.28488306
27MP0002132_abnormal_respiratory_system2.27550521
28MP0000383_abnormal_hair_follicle2.25731358
29MP0003011_delayed_dark_adaptation2.18365253
30MP0002102_abnormal_ear_morphology2.18162349
31MP0002277_abnormal_respiratory_mucosa2.17266412
32MP0008995_early_reproductive_senescence2.15288937
33MP0008789_abnormal_olfactory_epithelium2.10310020
34MP0000653_abnormal_sex_gland2.08331732
35MP0002161_abnormal_fertility/fecundity2.05816267
36MP0002909_abnormal_adrenal_gland2.04453236
37MP0003786_premature_aging2.04023282
38MP0010094_abnormal_chromosome_stability1.99802313
39MP0005551_abnormal_eye_electrophysiolog1.95511438
40MP0002160_abnormal_reproductive_system1.94182584
41MP0002837_dystrophic_cardiac_calcinosis1.93152690
42MP0008260_abnormal_autophagy1.89036876
43MP0006292_abnormal_olfactory_placode1.81185955
44MP0000566_synostosis1.81144225
45MP0008058_abnormal_DNA_repair1.74270220
46MP0010678_abnormal_skin_adnexa1.73361577
47MP0003077_abnormal_cell_cycle1.73124288
48MP0008872_abnormal_physiological_respon1.71896118
49MP0004885_abnormal_endolymph1.70764116
50MP0002638_abnormal_pupillary_reflex1.70655121
51MP0005395_other_phenotype1.70395563
52MP0003806_abnormal_nucleotide_metabolis1.68008735
53MP0003646_muscle_fatigue1.66302194
54MP0005253_abnormal_eye_physiology1.64574325
55MP0008932_abnormal_embryonic_tissue1.60770469
56MP0008004_abnormal_stomach_pH1.59475432
57MP0001485_abnormal_pinna_reflex1.58722718
58MP0003283_abnormal_digestive_organ1.55376440
59MP0003123_paternal_imprinting1.51335729
60MP0006072_abnormal_retinal_apoptosis1.50588585
61MP0005377_hearing/vestibular/ear_phenot1.46826969
62MP0003878_abnormal_ear_physiology1.46826969
63MP0000631_abnormal_neuroendocrine_gland1.40585175
64MP0005394_taste/olfaction_phenotype1.39784022
65MP0005499_abnormal_olfactory_system1.39784022
66MP0005389_reproductive_system_phenotype1.39125803
67MP0001968_abnormal_touch/_nociception1.37011230
68MP0002734_abnormal_mechanical_nocicepti1.34899455
69MP0009745_abnormal_behavioral_response1.33008051
70MP0003880_abnormal_central_pattern1.32732040
71MP0002928_abnormal_bile_duct1.26119937
72MP0004133_heterotaxia1.22450353
73MP0005083_abnormal_biliary_tract1.19345873
74MP0001944_abnormal_pancreas_morphology1.18838865
75MP0002282_abnormal_trachea_morphology1.18797078
76MP0000427_abnormal_hair_cycle1.16986846
77MP0001486_abnormal_startle_reflex1.15867210
78MP0003787_abnormal_imprinting1.15625894
79MP0002272_abnormal_nervous_system1.14461004
80MP0003890_abnormal_embryonic-extraembry1.13393099
81MP0000569_abnormal_digit_pigmentation1.12972323
82MP0000428_abnormal_craniofacial_morphol1.10054653
83MP0003938_abnormal_ear_development1.09727046
84MP0002876_abnormal_thyroid_physiology1.09384807
85MP0004742_abnormal_vestibular_system1.07862394
86MP0002736_abnormal_nociception_after1.06928143
87MP0002557_abnormal_social/conspecific_i1.06393745
88MP0001730_embryonic_growth_arrest1.05457357
89MP0001440_abnormal_grooming_behavior1.05038010
90MP0000026_abnormal_inner_ear1.02620607
91MP0002735_abnormal_chemical_nociception1.02166329
92MP0002084_abnormal_developmental_patter1.02112875
93MP0003937_abnormal_limbs/digits/tail_de1.01761128
94MP0001529_abnormal_vocalization1.00978025
95MP0001970_abnormal_pain_threshold0.97995067
96MP0009046_muscle_twitch0.97874053
97MP0006276_abnormal_autonomic_nervous0.96428484
98MP0001502_abnormal_circadian_rhythm0.95526530
99MP0004142_abnormal_muscle_tone0.95378761
100MP0002085_abnormal_embryonic_tissue0.94746395
101MP0005379_endocrine/exocrine_gland_phen0.92704078
102MP0005085_abnormal_gallbladder_physiolo0.92330551
103MP0002229_neurodegeneration0.91204526
104MP0004147_increased_porphyrin_level0.90559850
105MP0002168_other_aberrant_phenotype0.90337609
106MP0005195_abnormal_posterior_eye0.89438288
107MP0010386_abnormal_urinary_bladder0.87431652
108MP0002938_white_spotting0.86670301
109MP0002254_reproductive_system_inflammat0.85759980
110MP0000372_irregular_coat_pigmentation0.84868694
111MP0000013_abnormal_adipose_tissue0.84363276
112MP0002693_abnormal_pancreas_physiology0.83861973
113MP0002572_abnormal_emotion/affect_behav0.82408529
114MP0001905_abnormal_dopamine_level0.81424211
115MP0003936_abnormal_reproductive_system0.81333817
116MP0005084_abnormal_gallbladder_morpholo0.81057035
117MP0001963_abnormal_hearing_physiology0.80453442
118MP0004782_abnormal_surfactant_physiolog0.80159023
119MP0000647_abnormal_sebaceous_gland0.80039440
120MP0001765_abnormal_ion_homeostasis0.79208864
121MP0005220_abnormal_exocrine_pancreas0.78912135
122MP0002133_abnormal_respiratory_system0.78503261
123MP0005388_respiratory_system_phenotype0.78503261
124MP0002234_abnormal_pharynx_morphology0.78121040
125MP0001672_abnormal_embryogenesis/_devel0.77869067
126MP0005380_embryogenesis_phenotype0.77869067
127MP0002269_muscular_atrophy0.77313514
128MP0002405_respiratory_system_inflammati0.77047489
129MP0001727_abnormal_embryo_implantation0.75618247
130MP0001346_abnormal_lacrimal_gland0.75582657
131MP0005636_abnormal_mineral_homeostasis0.75459997
132MP0005332_abnormal_amino_acid0.75350163
133MP0001324_abnormal_eye_pigmentation0.74690126
134MP0002233_abnormal_nose_morphology0.74296620
135MP0005647_abnormal_sex_gland0.73391866
136MP0001756_abnormal_urination0.69327396
137MP0003186_abnormal_redox_activity0.68621008
138MP0003699_abnormal_female_reproductive0.66259602
139MP0001661_extended_life_span0.65987850
140MP0001919_abnormal_reproductive_system0.64896999
141MP0000350_abnormal_cell_proliferation0.62126659
142MP0003861_abnormal_nervous_system0.61558216
143MP0001958_emphysema0.61549095
144MP0008007_abnormal_cellular_replicative0.61407257
145MP0001293_anophthalmia0.61391690
146MP0002080_prenatal_lethality0.61203267
147MP0000432_abnormal_head_morphology0.61194414
148MP0010307_abnormal_tumor_latency0.58985235
149MP0002249_abnormal_larynx_morphology0.58555771
150MP0001986_abnormal_taste_sensitivity0.57779256
151MP0005646_abnormal_pituitary_gland0.56485135
152MP0000613_abnormal_salivary_gland0.56379017
153MP0001697_abnormal_embryo_size0.56219667
154MP0001286_abnormal_eye_development0.55404240
155MP0005187_abnormal_penis_morphology0.54831738
156MP0003634_abnormal_glial_cell0.54681987
157MP0002092_abnormal_eye_morphology0.53318985
158MP0001542_abnormal_bone_strength0.52937564
159MP0005391_vision/eye_phenotype0.52823499
160MP0002136_abnormal_kidney_physiology0.52408976
161MP0005666_abnormal_adipose_tissue0.51371710
162MP0003950_abnormal_plasma_membrane0.50238340
163MP0003984_embryonic_growth_retardation0.49847734
164MP0000750_abnormal_muscle_regeneration0.49732981
165MP0002163_abnormal_gland_morphology0.49586717
166MP0005266_abnormal_metabolism0.48612653
167MP0001119_abnormal_female_reproductive0.47477155

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.55878976
2Abnormal respiratory motile cilium morphology (HP:0005938)8.91893187
3Abnormal respiratory epithelium morphology (HP:0012253)8.91893187
4Absent/shortened dynein arms (HP:0200106)8.43247258
5Dynein arm defect of respiratory motile cilia (HP:0012255)8.43247258
6Chronic bronchitis (HP:0004469)7.17027546
7Bronchiectasis (HP:0002110)5.34992315
8Nasal polyposis (HP:0100582)4.41162982
9Infertility (HP:0000789)4.20059460
10Pancreatic fibrosis (HP:0100732)3.83310827
11Abnormality of the nasal mucosa (HP:0000433)3.75704242
12Bronchitis (HP:0012387)3.72885240
13Recurrent sinusitis (HP:0011108)3.34467914
14Chronic hepatic failure (HP:0100626)3.26494037
15Median cleft lip (HP:0000161)3.14214210
16Nephronophthisis (HP:0000090)3.09086989
17True hermaphroditism (HP:0010459)3.01483908
18Hyperventilation (HP:0002883)2.94522806
19Progressive cerebellar ataxia (HP:0002073)2.91974881
20Male infertility (HP:0003251)2.91950783
21Delusions (HP:0000746)2.76284858
22Supernumerary spleens (HP:0009799)2.73834664
23Myokymia (HP:0002411)2.73228213
24Action tremor (HP:0002345)2.70202561
25Recurrent otitis media (HP:0000403)2.66070864
26Pancreatic cysts (HP:0001737)2.61361071
27Abnormal drinking behavior (HP:0030082)2.56341260
28Polydipsia (HP:0001959)2.56341260
29Abnormality of binocular vision (HP:0011514)2.56213081
30Diplopia (HP:0000651)2.56213081
31Facial cleft (HP:0002006)2.45784562
32Abnormality of the renal cortex (HP:0011035)2.45474599
33Molar tooth sign on MRI (HP:0002419)2.45432159
34Abnormality of midbrain morphology (HP:0002418)2.45432159
35Tubular atrophy (HP:0000092)2.45390866
36Furrowed tongue (HP:0000221)2.43993447
37Chronic sinusitis (HP:0011109)2.42082851
38Gastrointestinal infarctions (HP:0005244)2.39818272
39Chronic otitis media (HP:0000389)2.35120527
40Impulsivity (HP:0100710)2.32700475
41Abnormality of the renal medulla (HP:0100957)2.32257660
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.27136097
43Tubulointerstitial nephritis (HP:0001970)2.27066539
44Decreased circulating renin level (HP:0003351)2.25772068
45Hyperactive renin-angiotensin system (HP:0000841)2.20224997
46Asplenia (HP:0001746)2.17144830
47Postaxial foot polydactyly (HP:0001830)2.15081719
48Cheilitis (HP:0100825)2.15001272
49Congenital hepatic fibrosis (HP:0002612)2.09941005
50Cystic liver disease (HP:0006706)2.07861399
51Medial flaring of the eyebrow (HP:0010747)2.06998136
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5827309
53Abnormal respiratory motile cilium physiology (HP:0012261)11.0703084
54Abnormal ciliary motility (HP:0012262)10.2207966
55Sensorimotor neuropathy (HP:0007141)1.96263116
56Oculomotor apraxia (HP:0000657)1.95756866
57Atelectasis (HP:0100750)1.95344568
58Abnormality of the prostate (HP:0008775)1.94213263
59Vaginal atresia (HP:0000148)1.91984456
60Abnormal spermatogenesis (HP:0008669)1.91664518
61Aplasia/Hypoplasia of the tongue (HP:0010295)1.90185702
62Decreased central vision (HP:0007663)1.89299338
63Fibular hypoplasia (HP:0003038)1.88271926
64Taurodontia (HP:0000679)1.87170100
65Abnormality of permanent molar morphology (HP:0011071)1.87170100
66Abnormality of the dental root (HP:0006486)1.87170100
67Polyuria (HP:0000103)1.85724939
68Abnormal rod and cone electroretinograms (HP:0008323)1.83293813
69Occipital encephalocele (HP:0002085)1.81937815
70Congenital primary aphakia (HP:0007707)1.81675109
71Abnormality of male internal genitalia (HP:0000022)1.80671579
72Gait imbalance (HP:0002141)1.80542368
73Abnormality of molar (HP:0011077)1.80264032
74Abnormality of molar morphology (HP:0011070)1.80264032
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79808897
76Tachypnea (HP:0002789)1.77213633
77Abnormality of the fetal cardiovascular system (HP:0010948)1.76329843
78Abnormal umbilical cord blood vessels (HP:0011403)1.76329843
79Single umbilical artery (HP:0001195)1.76329843
80Breast hypoplasia (HP:0003187)1.74747554
81Abnormality of the umbilical cord (HP:0010881)1.73192398
82Hyperglycinemia (HP:0002154)1.73037773
83Hyperglycinuria (HP:0003108)1.70047434
84Azoospermia (HP:0000027)1.69636406
85Abnormality of renin-angiotensin system (HP:0000847)1.68167852
86Concave nail (HP:0001598)1.67751709
87Abnormality of the dental pulp (HP:0006479)1.67273225
88Congenital stationary night blindness (HP:0007642)1.64578634
89Male pseudohermaphroditism (HP:0000037)1.64175767
90Renal salt wasting (HP:0000127)1.62462824
91Large for gestational age (HP:0001520)1.62436717
92Bile duct proliferation (HP:0001408)1.59655062
93Abnormal biliary tract physiology (HP:0012439)1.59655062
94Anencephaly (HP:0002323)1.58415435
95Hyperaldosteronism (HP:0000859)1.57125953
96Poor coordination (HP:0002370)1.56971192
97Hypothermia (HP:0002045)1.55946672
98Abnormal ventriculo-arterial connection (HP:0011563)1.55406940
99Transposition of the great arteries (HP:0001669)1.55406940
100Abnormal connection of the cardiac segments (HP:0011545)1.55406940
101Nephropathy (HP:0000112)1.55192273
102Abnormality of renal excretion (HP:0011036)1.54213866
103Nephrogenic diabetes insipidus (HP:0009806)1.54139724
104Bell-shaped thorax (HP:0001591)1.53883964
105Tubulointerstitial abnormality (HP:0001969)1.53620536
106Ventricular fibrillation (HP:0001663)1.53293676
107Tubulointerstitial fibrosis (HP:0005576)1.53280892
108Stage 5 chronic kidney disease (HP:0003774)1.53047442
109Pulmonary fibrosis (HP:0002206)1.52975567
110Carpal bone hypoplasia (HP:0001498)1.49829805
111Abolished electroretinogram (ERG) (HP:0000550)1.48609499
112Preaxial hand polydactyly (HP:0001177)1.47587245
113Abnormal urine output (HP:0012590)1.45114764
114Abnormality of macular pigmentation (HP:0008002)1.44516090
115Recurrent bronchitis (HP:0002837)1.43457036
116Retinitis pigmentosa (HP:0000510)1.43449314
117Stomach cancer (HP:0012126)1.42244257
118Abnormality of dentin (HP:0010299)1.41080159
119Multicystic kidney dysplasia (HP:0000003)1.40629328
120Genital tract atresia (HP:0001827)1.40347136
121Birth length less than 3rd percentile (HP:0003561)1.38799507
122Abnormality of serine family amino acid metabolism (HP:0010894)1.38115535
123Abnormality of glycine metabolism (HP:0010895)1.38115535
124Chronic obstructive pulmonary disease (HP:0006510)1.37792717
125Obstructive lung disease (HP:0006536)1.37792717
126Postaxial hand polydactyly (HP:0001162)1.37523342
127Type II lissencephaly (HP:0007260)1.37253050
128Cerebral hypomyelination (HP:0006808)1.37142965
129Absent speech (HP:0001344)1.34219019
130Disproportionate short-trunk short stature (HP:0003521)1.34077274
131Hypokalemic alkalosis (HP:0001949)1.34023558
132Aplasia/Hypoplasia of the fibula (HP:0006492)1.32282792
133Short ribs (HP:0000773)1.32104022
134Abnormality of abdominal situs (HP:0011620)1.31623224
135Abdominal situs inversus (HP:0003363)1.31623224
136Narrow forehead (HP:0000341)1.31239814
137Aganglionic megacolon (HP:0002251)1.30927261
138Sclerocornea (HP:0000647)1.30796326
139Hyperkalemia (HP:0002153)1.30746161
140Methylmalonic acidemia (HP:0002912)1.30665027
141Pendular nystagmus (HP:0012043)1.30104184
142Anophthalmia (HP:0000528)1.29041438
143Bony spicule pigmentary retinopathy (HP:0007737)1.27562189
144Prominent nasal bridge (HP:0000426)1.26116252
145Attenuation of retinal blood vessels (HP:0007843)1.25983267
146Ketoacidosis (HP:0001993)1.24721785
147Hypomagnesemia (HP:0002917)1.23785583
148Aplasia/hypoplasia of the uterus (HP:0008684)1.22427152
149Gaze-evoked nystagmus (HP:0000640)1.21387918
150Renal dysplasia (HP:0000110)1.18995925
151Highly arched eyebrow (HP:0002553)1.18063367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.84480267
2FRK4.97320492
3PDK34.46952213
4PDK44.46952213
5WEE14.43433025
6MAPK154.13097247
7TAOK13.48872762
8BUB13.04163124
9TAOK23.03741729
10PDK23.01834658
11MAP4K22.94774768
12MAP3K32.80219490
13ADRBK22.60334542
14EPHA22.55649981
15BMPR1B2.50691794
16TSSK62.35758731
17MAP3K112.27926287
18TTK2.15888081
19MAP2K31.93635843
20ACVR1B1.84596633
21PLK41.80148998
22MAP3K41.79029998
23ZAK1.72015371
24BCR1.71270040
25NEK21.66607828
26MAPKAPK31.61548382
27NLK1.50320489
28INSRR1.43927508
29DYRK31.43699020
30CASK1.42058053
31STK241.41535119
32EIF2AK11.38477218
33EIF2AK31.35288785
34FGFR21.34621208
35OXSR11.34388900
36MAPK131.33089763
37PLK31.32556015
38PLK11.32041807
39GRK11.28961656
40MKNK21.24881983
41TESK11.23335050
42PASK1.19318557
43AKT31.18886698
44AURKA1.12485639
45BRSK21.08528642
46MST41.07935360
47ADRBK11.06524188
48NUAK11.06411682
49PRKD31.04811749
50NME21.00532389
51VRK10.98485935
52STK160.97673778
53PLK20.97334292
54PRKCE0.94993949
55CHEK20.93605230
56TAOK30.89773618
57SRPK10.89607536
58MAP3K80.89450701
59PAK30.89324936
60PHKG10.88148693
61PHKG20.88148693
62ERBB30.85939876
63MAP3K20.80834707
64MARK10.80423860
65DAPK20.79737750
66NEK60.78879326
67STK390.74375523
68CSNK1G10.74285622
69LMTK20.74267873
70TRIM280.73594826
71FER0.73368334
72IRAK30.73270601
73NTRK30.72255428
74STK380.71579185
75NEK10.70100527
76CSNK1G20.69940878
77MAP3K50.66948193
78BRSK10.66465010
79STK100.65364219
80PIK3CA0.63491998
81CSNK1G30.63014691
82LATS20.61179850
83AURKB0.61136213
84MUSK0.60847060
85EPHA30.60243378
86STK38L0.59731582
87ERBB20.59250191
88CAMKK20.58836463
89ALK0.58752651
90CAMKK10.57945944
91WNK30.56151303
92CDK30.55239608
93TEC0.55017552
94PINK10.53955687
95MAP3K70.53866003
96TGFBR10.53463998
97CAMK2A0.52812133
98TIE10.52359831
99PRKCQ0.52261800
100CDC70.52034900
101TRIB30.51764533
102CSNK1A10.51061426
103WNK40.50873006
104STK30.50813949
105STK110.50703589
106PRKAA20.50649994
107CHUK0.49242388
108PRKCG0.48553294
109PRKACA0.48191127
110MAP3K90.46145930
111RPS6KA50.45655207
112MKNK10.45212319
113CSNK1A1L0.45152089
114TNIK0.44845994
115CSNK1E0.44646566
116CCNB10.42989469
117CDC42BPA0.42877926
118CHEK10.42854451
119PAK20.42326724
120PAK10.41996823
121ICK0.41335135
122NTRK20.40072478
123GRK70.38649674
124MAP2K20.37662368
125PRKCA0.37223288
126MAP3K120.37079176
127PRKCZ0.36631714
128CSNK2A10.36594164
129PIM20.36204614
130DYRK1A0.35085842
131MAPKAPK50.35072329
132BRAF0.34706274
133PAK40.34275896
134TLK10.33978040
135EPHA40.33885528
136LIMK10.33547197
137PRKCI0.32632688
138ARAF0.32043698
139TRPM70.31780094
140PTK2B0.30195001
141BCKDK0.30013752
142MAP2K60.28382064
143IKBKB0.27314611
144ATM0.27089882
145EIF2AK20.26377372
146ABL10.26267840
147GSK3A0.26248740
148SIK20.26045153
149CSNK2A20.25389027
150PRKAA10.25309324
151TESK20.23415589
152PRKG10.23090961
153CDK40.21759995
154MAP2K70.21651618
155CDK20.21623360
156TYRO30.21214973
157ATR0.21079233
158ITK0.18305839
159PIK3CG0.18198977
160CDK70.17947129
161MAP3K10.17009304
162CDK10.16941672
163PRKDC0.15941958
164IRAK10.15136837
165NME10.14650953
166DYRK20.12985888

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.97229541
2Proteasome_Homo sapiens_hsa030503.43955296
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24305806
4RNA transport_Homo sapiens_hsa030132.80246171
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.79759899
6RNA polymerase_Homo sapiens_hsa030202.79711728
7Pyrimidine metabolism_Homo sapiens_hsa002402.35737734
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34642922
9Basal transcription factors_Homo sapiens_hsa030222.20692101
10Caffeine metabolism_Homo sapiens_hsa002322.15769599
11Pentose phosphate pathway_Homo sapiens_hsa000302.13049021
12Phenylalanine metabolism_Homo sapiens_hsa003602.07291588
13Huntingtons disease_Homo sapiens_hsa050162.06405698
14beta-Alanine metabolism_Homo sapiens_hsa004102.04151394
15Oxidative phosphorylation_Homo sapiens_hsa001902.00468480
16Tyrosine metabolism_Homo sapiens_hsa003501.88070382
17Regulation of autophagy_Homo sapiens_hsa041401.84629443
18Fructose and mannose metabolism_Homo sapiens_hsa000511.84157324
19Homologous recombination_Homo sapiens_hsa034401.81793745
20Propanoate metabolism_Homo sapiens_hsa006401.81101657
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.79135569
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78432598
23* Purine metabolism_Homo sapiens_hsa002301.78428897
24Glutathione metabolism_Homo sapiens_hsa004801.77422110
25Fanconi anemia pathway_Homo sapiens_hsa034601.77234664
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76255660
27Cell cycle_Homo sapiens_hsa041101.64238918
28Peroxisome_Homo sapiens_hsa041461.59614861
29ABC transporters_Homo sapiens_hsa020101.56157265
30DNA replication_Homo sapiens_hsa030301.54690119
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.50885781
32Nucleotide excision repair_Homo sapiens_hsa034201.49251892
33Protein export_Homo sapiens_hsa030601.47236614
34Nicotine addiction_Homo sapiens_hsa050331.46778557
35Retinol metabolism_Homo sapiens_hsa008301.42382241
36Ribosome_Homo sapiens_hsa030101.40856107
37Linoleic acid metabolism_Homo sapiens_hsa005911.36965383
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36508227
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35794581
40Spliceosome_Homo sapiens_hsa030401.35753899
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35515385
42Sphingolipid metabolism_Homo sapiens_hsa006001.34466413
43Oocyte meiosis_Homo sapiens_hsa041141.33726096
44Tryptophan metabolism_Homo sapiens_hsa003801.33230505
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32114920
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31340894
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30869644
48Glycerolipid metabolism_Homo sapiens_hsa005611.28297060
49Parkinsons disease_Homo sapiens_hsa050121.23962733
50mRNA surveillance pathway_Homo sapiens_hsa030151.21605069
51p53 signaling pathway_Homo sapiens_hsa041151.17488029
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17196684
53Antigen processing and presentation_Homo sapiens_hsa046121.13690442
54Olfactory transduction_Homo sapiens_hsa047401.13158977
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10924499
56Vitamin digestion and absorption_Homo sapiens_hsa049771.08973358
57Arachidonic acid metabolism_Homo sapiens_hsa005901.07570553
58Salivary secretion_Homo sapiens_hsa049701.07358351
59Mismatch repair_Homo sapiens_hsa034301.06316302
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.06162852
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04542594
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04239178
63Mineral absorption_Homo sapiens_hsa049781.01777842
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99835421
65Fatty acid degradation_Homo sapiens_hsa000710.99719543
66PPAR signaling pathway_Homo sapiens_hsa033200.98822619
67Insulin secretion_Homo sapiens_hsa049110.97525942
68Hippo signaling pathway_Homo sapiens_hsa043900.96183496
69Tight junction_Homo sapiens_hsa045300.96135855
70Cardiac muscle contraction_Homo sapiens_hsa042600.94506984
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93132760
72Epstein-Barr virus infection_Homo sapiens_hsa051690.92273424
73Biosynthesis of amino acids_Homo sapiens_hsa012300.91466369
74Alzheimers disease_Homo sapiens_hsa050100.89230110
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88672188
76Selenocompound metabolism_Homo sapiens_hsa004500.88477311
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88226710
78Ether lipid metabolism_Homo sapiens_hsa005650.84409262
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83328850
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82609359
81Pyruvate metabolism_Homo sapiens_hsa006200.82044167
82Hedgehog signaling pathway_Homo sapiens_hsa043400.81982631
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76147808
84Serotonergic synapse_Homo sapiens_hsa047260.75469986
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74424019
86Base excision repair_Homo sapiens_hsa034100.74180726
87* Metabolic pathways_Homo sapiens_hsa011000.70340197
88Circadian rhythm_Homo sapiens_hsa047100.70029004
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69974731
90Basal cell carcinoma_Homo sapiens_hsa052170.69019381
91Circadian entrainment_Homo sapiens_hsa047130.68875760
92Glutamatergic synapse_Homo sapiens_hsa047240.68464974
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68135367
94Carbon metabolism_Homo sapiens_hsa012000.67554996
95Dorso-ventral axis formation_Homo sapiens_hsa043200.66405450
96Fatty acid biosynthesis_Homo sapiens_hsa000610.65202826
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61274364
98RNA degradation_Homo sapiens_hsa030180.60029127
99Arginine and proline metabolism_Homo sapiens_hsa003300.58327404
100Sulfur metabolism_Homo sapiens_hsa009200.56918478
101Butanoate metabolism_Homo sapiens_hsa006500.56008066
102Morphine addiction_Homo sapiens_hsa050320.53864894
103Inositol phosphate metabolism_Homo sapiens_hsa005620.53579389
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51445140
105Starch and sucrose metabolism_Homo sapiens_hsa005000.49340286
106Steroid biosynthesis_Homo sapiens_hsa001000.48217866
107Cocaine addiction_Homo sapiens_hsa050300.47243900
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.46594071
109GABAergic synapse_Homo sapiens_hsa047270.46072711
110Nitrogen metabolism_Homo sapiens_hsa009100.44948006
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44388983
112Fat digestion and absorption_Homo sapiens_hsa049750.43165392
113Chemical carcinogenesis_Homo sapiens_hsa052040.42163027
114Synaptic vesicle cycle_Homo sapiens_hsa047210.40840510
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38791671
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38742772
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38582534
118AMPK signaling pathway_Homo sapiens_hsa041520.38500717
119Renin-angiotensin system_Homo sapiens_hsa046140.36839048
120Histidine metabolism_Homo sapiens_hsa003400.35515094
121Calcium signaling pathway_Homo sapiens_hsa040200.35257859
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.34622794
123Type I diabetes mellitus_Homo sapiens_hsa049400.34588177
124Wnt signaling pathway_Homo sapiens_hsa043100.33137419
125Amphetamine addiction_Homo sapiens_hsa050310.32123861
126One carbon pool by folate_Homo sapiens_hsa006700.31683257
127Estrogen signaling pathway_Homo sapiens_hsa049150.29024450
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26866935
129Ovarian steroidogenesis_Homo sapiens_hsa049130.26749287
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25269525
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.24783980
132Glucagon signaling pathway_Homo sapiens_hsa049220.24273731
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23396767
134Phototransduction_Homo sapiens_hsa047440.23296217
135Folate biosynthesis_Homo sapiens_hsa007900.22777113
136Collecting duct acid secretion_Homo sapiens_hsa049660.22583606
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21058262
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18754124
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18584067
140Protein digestion and absorption_Homo sapiens_hsa049740.18119805
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15116128
142Pancreatic secretion_Homo sapiens_hsa049720.14745389
143Taste transduction_Homo sapiens_hsa047420.14245157
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13733597
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10276481

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