AKAIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.90641161
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31327958
3neuronal action potential propagation (GO:0019227)5.15553378
4regulation of synaptic vesicle exocytosis (GO:2000300)5.12691166
5vocalization behavior (GO:0071625)5.03151990
6cellular potassium ion homeostasis (GO:0030007)4.98017827
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96953568
8synaptic vesicle maturation (GO:0016188)4.82170264
9neurotransmitter secretion (GO:0007269)4.78379826
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76645387
11gamma-aminobutyric acid signaling pathway (GO:0007214)4.74864700
12cellular ketone body metabolic process (GO:0046950)4.74319907
13glutamate secretion (GO:0014047)4.67153392
14positive regulation of synapse maturation (GO:0090129)4.63509220
15locomotory exploration behavior (GO:0035641)4.61648008
16neurotransmitter-gated ion channel clustering (GO:0072578)4.49241174
17regulation of synaptic vesicle transport (GO:1902803)4.44426578
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.44024651
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.40666642
20inositol phosphate catabolic process (GO:0071545)4.35224776
21cerebellar Purkinje cell differentiation (GO:0021702)4.35100664
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31354991
23insulin secretion (GO:0030073)4.24594036
24lactate metabolic process (GO:0006089)4.24229491
25glycerophospholipid catabolic process (GO:0046475)4.22284757
26respiratory chain complex IV assembly (GO:0008535)4.20441459
27gamma-aminobutyric acid transport (GO:0015812)4.18660369
28ketone body metabolic process (GO:1902224)4.18146776
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.12706715
30regulation of glutamate receptor signaling pathway (GO:1900449)4.12174745
31negative regulation of execution phase of apoptosis (GO:1900118)4.12107046
32neuron-neuron synaptic transmission (GO:0007270)4.06158562
33regulation of glucokinase activity (GO:0033131)4.05703457
34regulation of hexokinase activity (GO:1903299)4.05703457
35regulation of type B pancreatic cell apoptotic process (GO:2000674)4.04481256
36protein localization to synapse (GO:0035418)4.02989573
37phosphorylated carbohydrate dephosphorylation (GO:0046838)3.97856328
38inositol phosphate dephosphorylation (GO:0046855)3.97856328
39neurotransmitter transport (GO:0006836)3.94066460
40synaptic transmission, glutamatergic (GO:0035249)3.90647082
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90618763
42water-soluble vitamin biosynthetic process (GO:0042364)3.89581889
43negative regulation of protein oligomerization (GO:0032460)3.87861023
44neuron cell-cell adhesion (GO:0007158)3.87451051
45endocrine pancreas development (GO:0031018)3.86655646
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.84956747
47peptide hormone processing (GO:0016486)3.81544817
48synaptic vesicle endocytosis (GO:0048488)3.81176287
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81160352
50regulation of neurotransmitter uptake (GO:0051580)3.80255564
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.79251858
52glutamate receptor signaling pathway (GO:0007215)3.78173544
53neuromuscular process controlling posture (GO:0050884)3.76321427
54dendritic spine morphogenesis (GO:0060997)3.75922131
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73594309
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.72876098
57long-term memory (GO:0007616)3.69516701
58cerebellar granule cell differentiation (GO:0021707)3.68990851
59regulation of synapse maturation (GO:0090128)3.66415384
60cytochrome complex assembly (GO:0017004)3.63555551
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61023621
62potassium ion homeostasis (GO:0055075)3.57459763
63sodium ion export (GO:0071436)3.55891478
64response to pheromone (GO:0019236)3.54928075
65positive regulation of membrane potential (GO:0045838)3.50804611
66polyol catabolic process (GO:0046174)3.48962226
67regulation of neurotransmitter levels (GO:0001505)3.48314512
68layer formation in cerebral cortex (GO:0021819)3.45934510
69positive regulation of glycolytic process (GO:0045821)3.44533207
70long-term synaptic potentiation (GO:0060291)3.44421406
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43850437
72regulation of neurotransmitter secretion (GO:0046928)3.41059469
73activation of protein kinase A activity (GO:0034199)3.39907767
74sphingomyelin metabolic process (GO:0006684)3.39041145
75positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.38508976
76nitric oxide biosynthetic process (GO:0006809)3.38280071
77cell differentiation in hindbrain (GO:0021533)3.36887689
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36240416
79detection of calcium ion (GO:0005513)3.35913738
80negative regulation of complement activation (GO:0045916)3.34399397
81positive regulation of insulin secretion (GO:0032024)3.34163913
82exploration behavior (GO:0035640)3.31254558
83membrane depolarization during action potential (GO:0086010)3.29742642
84long term synaptic depression (GO:0060292)3.27584030
85transferrin transport (GO:0033572)3.26759396
86striatum development (GO:0021756)3.26581009
87regulation of neurotransmitter transport (GO:0051588)3.26097599
88regulation of synapse structural plasticity (GO:0051823)3.25789872
89regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25766083
90regulation of voltage-gated calcium channel activity (GO:1901385)3.25349454
91regulation of vesicle fusion (GO:0031338)3.25280739
92energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.24191884
93ATP hydrolysis coupled proton transport (GO:0015991)3.24191884
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.21422445
95nitric oxide mediated signal transduction (GO:0007263)3.19844957
96innervation (GO:0060384)3.18325574
97regulation of neuronal synaptic plasticity (GO:0048168)3.18166905
98synaptic vesicle transport (GO:0048489)3.18055668
99establishment of synaptic vesicle localization (GO:0097480)3.18055668
100synaptic transmission (GO:0007268)3.17828192
101negative regulation of hormone biosynthetic process (GO:0032353)3.17196932
102succinate metabolic process (GO:0006105)3.16068016
103cell communication by electrical coupling (GO:0010644)3.16015361
104auditory receptor cell differentiation (GO:0042491)3.14848380
105positive regulation of dendritic spine morphogenesis (GO:0061003)3.14774737
106regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13049672
107inositol phosphate-mediated signaling (GO:0048016)3.12367344
108positive regulation of gluconeogenesis (GO:0045722)3.11340360
109positive regulation of meiosis (GO:0045836)3.11262725
110epithelial cell fate commitment (GO:0072148)3.11177150
111positive regulation of glomerulus development (GO:0090193)3.10843830
112ferric iron transport (GO:0015682)3.09967321
113trivalent inorganic cation transport (GO:0072512)3.09967321
114regulation of postsynaptic membrane potential (GO:0060078)3.09468406
115urinary tract smooth muscle contraction (GO:0014848)3.09185828
116positive regulation of peptide hormone secretion (GO:0090277)3.05968755
117positive regulation of histone H3-K4 methylation (GO:0051571)3.05342354
118membrane hyperpolarization (GO:0060081)3.04863403
119positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.03502824
120transmission of nerve impulse (GO:0019226)3.02265486
121signal peptide processing (GO:0006465)3.02023482
122mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.01905820
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.00304087
124adult walking behavior (GO:0007628)2.98527018
125renal tubule morphogenesis (GO:0061333)2.98280473
126L-alpha-amino acid transmembrane transport (GO:1902475)2.97212284
127positive regulation of peptide secretion (GO:0002793)2.94921933
128negative regulation of protein activation cascade (GO:2000258)2.93849974
129positive regulation of potassium ion transmembrane transport (GO:1901381)2.93756831
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93216901
131kidney morphogenesis (GO:0060993)2.93175810
132membrane depolarization (GO:0051899)2.91653703
133regulation of insulin secretion (GO:0050796)2.90375673
134aggressive behavior (GO:0002118)2.89571833
135dopamine transport (GO:0015872)2.88438352
136platelet dense granule organization (GO:0060155)2.88335363
137regulation of synaptic plasticity (GO:0048167)2.88275678
138signal release (GO:0023061)2.88256008
139positive regulation of meiotic cell cycle (GO:0051446)2.88055510
140detection of light stimulus involved in sensory perception (GO:0050962)2.87964198
141detection of light stimulus involved in visual perception (GO:0050908)2.87964198
142regulation of synaptic transmission, GABAergic (GO:0032228)2.87658753
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87014728
144zinc ion homeostasis (GO:0055069)2.84247009
145synapse assembly (GO:0007416)2.82844005
146proline transport (GO:0015824)2.82301856
147positive regulation of synaptic transmission (GO:0050806)2.81355036
148regulation of synaptic transmission (GO:0050804)2.80425626
149macroautophagy (GO:0016236)2.77143561
150establishment of vesicle localization (GO:0051650)2.76081692
151positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75856381
152cerebellar Purkinje cell layer development (GO:0021680)2.75735693
153positive regulation of calcium ion import (GO:0090280)2.75529607
154potassium ion transmembrane transport (GO:0071805)2.74670433
155cardiac left ventricle morphogenesis (GO:0003214)2.73243612
156peptide hormone secretion (GO:0030072)2.73118969
157myelin maintenance (GO:0043217)2.68081678
158protein complex biogenesis (GO:0070271)2.67422130
159positive regulation of actin filament depolymerization (GO:0030836)2.67402064
160regulation of peptide hormone secretion (GO:0090276)2.66956631
161peptide secretion (GO:0002790)2.63260075
162axoneme assembly (GO:0035082)2.62657331
163regulation of peptide secretion (GO:0002791)2.62078778
164dentate gyrus development (GO:0021542)2.61969509
165negative regulation of hormone metabolic process (GO:0032351)2.61650445
166glandular epithelial cell differentiation (GO:0002067)2.60738137
167peptidyl-cysteine modification (GO:0018198)2.60414820
168negative regulation of dendrite development (GO:2000171)2.56631367
169negative regulation of neurological system process (GO:0031645)2.56098376
170membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.55195139
171thyroid hormone metabolic process (GO:0042403)2.55104925
172toxin transport (GO:1901998)2.53015971
173protein prenylation (GO:0018342)2.52701498
174prenylation (GO:0097354)2.52701498
175L-phenylalanine catabolic process (GO:0006559)2.50988533
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50988533
177catecholamine transport (GO:0051937)2.49841866
178cellular zinc ion homeostasis (GO:0006882)2.49241211
179retinol metabolic process (GO:0042572)2.49015867
180phospholipid catabolic process (GO:0009395)2.48857544
181zinc ion transmembrane transport (GO:0071577)2.48342370
182fatty acid homeostasis (GO:0055089)2.47322566
183chemosensory behavior (GO:0007635)2.46650559
184negative regulation of humoral immune response (GO:0002921)2.45596965
185nephron tubule morphogenesis (GO:0072078)2.45586433
186nephron epithelium morphogenesis (GO:0072088)2.45586433
187regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44160757
188potassium ion export (GO:0071435)2.43320413
189positive regulation of protein autophosphorylation (GO:0031954)2.43217095
190response to amphetamine (GO:0001975)2.40476123
191sequestering of metal ion (GO:0051238)2.38667616
192regulation of calcium ion-dependent exocytosis (GO:0017158)2.38599156
193regulation of hormone secretion (GO:0046883)2.38423594
194positive regulation of macroautophagy (GO:0016239)2.37604541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.60792965
2EZH2_22144423_ChIP-Seq_EOC_Human4.94467675
3GBX2_23144817_ChIP-Seq_PC3_Human4.11064474
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16679366
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11774309
6REST_21632747_ChIP-Seq_MESCs_Mouse3.01433825
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94020183
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62757638
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57238252
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57238252
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57104843
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56738461
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52859079
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49668920
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.47433433
16DROSHA_22980978_ChIP-Seq_HELA_Human2.38594001
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38378851
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30263686
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.29911076
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.26741957
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.26731112
22TAF15_26573619_Chip-Seq_HEK293_Human2.19419172
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.18307786
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17684379
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.11462307
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08826214
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03748985
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03025042
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01805307
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00841720
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94105411
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87784018
33SMAD4_21799915_ChIP-Seq_A2780_Human1.87227807
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83242447
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79650284
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78473559
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73671389
38AR_21572438_ChIP-Seq_LNCaP_Human1.72457310
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70429518
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69406726
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68856640
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67862696
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63422923
44P300_19829295_ChIP-Seq_ESCs_Human1.52901796
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.51352289
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48501202
47ZNF274_21170338_ChIP-Seq_K562_Hela1.46296780
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45226907
49AR_25329375_ChIP-Seq_VCAP_Human1.43312745
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42762478
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42735821
52HTT_18923047_ChIP-ChIP_STHdh_Human1.40115351
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39630978
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39218259
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.38736176
56STAT3_23295773_ChIP-Seq_U87_Human1.38007190
57TP53_22573176_ChIP-Seq_HFKS_Human1.37805890
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35930947
59EWS_26573619_Chip-Seq_HEK293_Human1.35049017
60VDR_22108803_ChIP-Seq_LS180_Human1.33778792
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.33468760
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32863464
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32510922
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.31447916
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.30477219
66IGF1R_20145208_ChIP-Seq_DFB_Human1.29869925
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29333379
68P53_22387025_ChIP-Seq_ESCs_Mouse1.28755790
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27964404
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26732715
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.26732715
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26708020
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25938253
74CBP_20019798_ChIP-Seq_JUKART_Human1.25938253
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23857067
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.23848007
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23138952
78AR_19668381_ChIP-Seq_PC3_Human1.22445948
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.21462338
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21232161
81RNF2_27304074_Chip-Seq_NSC_Mouse1.21160329
82NANOG_19829295_ChIP-Seq_ESCs_Human1.20394443
83SOX2_19829295_ChIP-Seq_ESCs_Human1.20394443
84TCF4_23295773_ChIP-Seq_U87_Human1.19465975
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18555628
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.17944838
87CDX2_22108803_ChIP-Seq_LS180_Human1.17824805
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16950356
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15991789
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15765228
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.14215028
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13313144
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12502419
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12302573
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12118727
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12071828
97STAT3_18555785_Chip-Seq_ESCs_Mouse1.11922899
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10675556
99FUS_26573619_Chip-Seq_HEK293_Human1.10439362
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.09789417
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08984414
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08723362
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07879029
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07656868
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.07045659
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06973167
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06623462
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06582984
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.06140160
110RUNX2_22187159_ChIP-Seq_PCA_Human1.05364791
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04759795
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.01438755
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.00939170
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.00524660
115NCOR_22424771_ChIP-Seq_293T_Human0.99731480
116ER_23166858_ChIP-Seq_MCF-7_Human0.99082755
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98923403
118BCAT_22108803_ChIP-Seq_LS180_Human0.97821006
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97431384
120FLI1_21867929_ChIP-Seq_TH2_Mouse0.96649479
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96444087
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96083771
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95099721
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95016547
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94997160
126CTCF_18555785_Chip-Seq_ESCs_Mouse0.94877626
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94807017
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94309184
129P300_18555785_Chip-Seq_ESCs_Mouse0.94080378
130JUN_21703547_ChIP-Seq_K562_Human0.93041623
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92913420
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.91999097
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91548431
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91298325
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.91249791
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90988611
137TCF4_22108803_ChIP-Seq_LS180_Human0.87758594
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86413995
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.86223726
140RING1B_27294783_Chip-Seq_NPCs_Mouse0.85584499
141CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85508996
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.85418475
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.85375874
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85221487
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84778213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01959210
2MP0005379_endocrine/exocrine_gland_phen4.22332956
3MP0009046_muscle_twitch4.04034999
4MP0003635_abnormal_synaptic_transmissio3.73577605
5MP0002163_abnormal_gland_morphology3.44357653
6MP0003880_abnormal_central_pattern3.29143339
7MP0002064_seizures3.13474250
8MP0009745_abnormal_behavioral_response3.11650974
9MP0004270_analgesia2.95166907
10MP0002272_abnormal_nervous_system2.91490134
11MP0010234_abnormal_vibrissa_follicle2.87128043
12MP0002063_abnormal_learning/memory/cond2.82112821
13MP0002734_abnormal_mechanical_nocicepti2.70379669
14MP0002822_catalepsy2.67324211
15MP0002572_abnormal_emotion/affect_behav2.53898076
16MP0002139_abnormal_hepatobiliary_system2.38406840
17MP0001968_abnormal_touch/_nociception2.38375873
18MP0001486_abnormal_startle_reflex2.36598858
19MP0008569_lethality_at_weaning2.35666403
20MP0001501_abnormal_sleep_pattern2.35654222
21MP0005551_abnormal_eye_electrophysiolog2.29747668
22MP0010386_abnormal_urinary_bladder2.27166452
23MP0002909_abnormal_adrenal_gland2.25446458
24MP0002067_abnormal_sensory_capabilities2.25054423
25MP0001984_abnormal_olfaction2.20231168
26MP0002735_abnormal_chemical_nociception2.10641073
27MP0002736_abnormal_nociception_after2.06465617
28MP0001440_abnormal_grooming_behavior2.04088930
29MP0003195_calcinosis2.02257100
30MP0002184_abnormal_innervation1.95300889
31MP0002638_abnormal_pupillary_reflex1.88065221
32MP0008875_abnormal_xenobiotic_pharmacok1.85142034
33MP0009780_abnormal_chondrocyte_physiolo1.81705499
34MP0005423_abnormal_somatic_nervous1.77106334
35MP0001970_abnormal_pain_threshold1.76938787
36MP0003879_abnormal_hair_cell1.76225658
37MP0000013_abnormal_adipose_tissue1.74032639
38MP0005646_abnormal_pituitary_gland1.73690981
39MP0010329_abnormal_lipoprotein_level1.73237375
40MP0004142_abnormal_muscle_tone1.72874748
41MP0002837_dystrophic_cardiac_calcinosis1.70026888
42MP0001502_abnormal_circadian_rhythm1.68618394
43MP0001188_hyperpigmentation1.65583344
44MP0004147_increased_porphyrin_level1.62940623
45MP0002733_abnormal_thermal_nociception1.62395910
46MP0005386_behavior/neurological_phenoty1.60794824
47MP0004924_abnormal_behavior1.60794824
48MP0005220_abnormal_exocrine_pancreas1.60537245
49MP0003172_abnormal_lysosome_physiology1.57386500
50MP0002557_abnormal_social/conspecific_i1.56206869
51MP0006072_abnormal_retinal_apoptosis1.54936620
52MP0003787_abnormal_imprinting1.53755822
53MP0004233_abnormal_muscle_weight1.53730901
54MP0006276_abnormal_autonomic_nervous1.52519096
55MP0008877_abnormal_DNA_methylation1.52322980
56MP0000955_abnormal_spinal_cord1.49606524
57MP0003329_amyloid_beta_deposits1.47431678
58MP0004043_abnormal_pH_regulation1.46846998
59MP0004811_abnormal_neuron_physiology1.46353741
60MP0005332_abnormal_amino_acid1.43437684
61MP0008995_early_reproductive_senescence1.42017589
62MP0003122_maternal_imprinting1.41544240
63MP0002229_neurodegeneration1.39484764
64MP0002882_abnormal_neuron_morphology1.38923422
65MP0001529_abnormal_vocalization1.37929236
66MP0002090_abnormal_vision1.36568796
67MP0002066_abnormal_motor_capabilities/c1.36480015
68MP0004145_abnormal_muscle_electrophysio1.33264098
69MP0004885_abnormal_endolymph1.30264490
70MP0004858_abnormal_nervous_system1.30217386
71MP0005187_abnormal_penis_morphology1.29931108
72MP0001756_abnormal_urination1.28621126
73MP0000427_abnormal_hair_cycle1.27038990
74MP0004215_abnormal_myocardial_fiber1.24541548
75MP0005636_abnormal_mineral_homeostasis1.23741928
76MP0000751_myopathy1.19686846
77MP0010678_abnormal_skin_adnexa1.17333249
78MP0005174_abnormal_tail_pigmentation1.16435044
79MP0000516_abnormal_urinary_system1.15049253
80MP0005367_renal/urinary_system_phenotyp1.15049253
81MP0003633_abnormal_nervous_system1.14566471
82MP0003011_delayed_dark_adaptation1.11639272
83MP0005645_abnormal_hypothalamus_physiol1.09636991
84MP0003121_genomic_imprinting1.08407570
85MP0004133_heterotaxia1.07418669
86MP0005499_abnormal_olfactory_system1.06029743
87MP0005394_taste/olfaction_phenotype1.06029743
88MP0005365_abnormal_bile_salt1.03920595
89MP0005389_reproductive_system_phenotype1.02960377
90MP0008872_abnormal_physiological_respon1.02890622
91MP0005448_abnormal_energy_balance1.02456144
92MP0003631_nervous_system_phenotype1.02194867
93MP0002928_abnormal_bile_duct1.01061024
94MP0000778_abnormal_nervous_system1.00381975
95MP0003953_abnormal_hormone_level0.98685154
96MP0000538_abnormal_urinary_bladder0.98613983
97MP0001905_abnormal_dopamine_level0.96877806
98MP0005253_abnormal_eye_physiology0.96822582
99MP0003283_abnormal_digestive_organ0.95333289
100MP0002876_abnormal_thyroid_physiology0.95202473
101MP0002752_abnormal_somatic_nervous0.94189004
102MP0003183_abnormal_peptide_metabolism0.93732032
103MP0003632_abnormal_nervous_system0.92170974
104MP0005535_abnormal_body_temperature0.91774651
105MP0004036_abnormal_muscle_relaxation0.91620787
106MP0008961_abnormal_basal_metabolism0.91522659
107MP0005075_abnormal_melanosome_morpholog0.91062143
108MP0004019_abnormal_vitamin_homeostasis0.90597922
109MP0003646_muscle_fatigue0.90512012
110MP0001986_abnormal_taste_sensitivity0.89943278
111MP0004085_abnormal_heartbeat0.89915676
112MP0001963_abnormal_hearing_physiology0.89613263
113MP0002152_abnormal_brain_morphology0.89266083
114MP0000015_abnormal_ear_pigmentation0.87591640
115MP0002069_abnormal_eating/drinking_beha0.85990070
116MP0005084_abnormal_gallbladder_morpholo0.85102954
117MP0004742_abnormal_vestibular_system0.83076656
118MP0002254_reproductive_system_inflammat0.82419199
119MP0000639_abnormal_adrenal_gland0.81464659
120MP0000647_abnormal_sebaceous_gland0.81296194
121MP0000631_abnormal_neuroendocrine_gland0.80978298
122MP0002118_abnormal_lipid_homeostasis0.80554683
123MP0003634_abnormal_glial_cell0.79900608
124MP0001919_abnormal_reproductive_system0.79622013
125MP0006036_abnormal_mitochondrial_physio0.79229573
126MP0001661_extended_life_span0.78693402
127MP0002160_abnormal_reproductive_system0.78517757
128MP0000613_abnormal_salivary_gland0.77475971
129MP0005248_abnormal_Harderian_gland0.76668121
130MP0002234_abnormal_pharynx_morphology0.72438118
131MP0003137_abnormal_impulse_conducting0.68729653
132MP0006292_abnormal_olfactory_placode0.67964272
133MP0001270_distended_abdomen0.67736961
134MP0005195_abnormal_posterior_eye0.66184181
135MP0001177_atelectasis0.66119270
136MP0002332_abnormal_exercise_endurance0.65772721
137MP0006035_abnormal_mitochondrial_morpho0.64699166
138MP0004484_altered_response_of0.64316627
139MP0008874_decreased_physiological_sensi0.62380588
140MP0000003_abnormal_adipose_tissue0.59256543
141MP0002078_abnormal_glucose_homeostasis0.57936502
142MP0001944_abnormal_pancreas_morphology0.56922068
143MP0001765_abnormal_ion_homeostasis0.56878419
144MP0002693_abnormal_pancreas_physiology0.56321862
145MP0001664_abnormal_digestion0.55884540

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.97644334
2Febrile seizures (HP:0002373)6.08276793
3Atonic seizures (HP:0010819)5.92963377
4Epileptic encephalopathy (HP:0200134)5.68230813
5Absence seizures (HP:0002121)5.32424401
6Myokymia (HP:0002411)5.20419935
7Progressive cerebellar ataxia (HP:0002073)5.10528880
8Visual hallucinations (HP:0002367)5.07080084
9Hypoglycemic seizures (HP:0002173)5.01756299
10Hypoglycemic coma (HP:0001325)4.97630479
11Focal seizures (HP:0007359)4.89438383
12Dialeptic seizures (HP:0011146)4.55991227
13Hyperinsulinemic hypoglycemia (HP:0000825)4.55689237
14Ketoacidosis (HP:0001993)4.38383076
15Generalized tonic-clonic seizures (HP:0002069)4.09920846
16Action tremor (HP:0002345)3.95889312
17Large for gestational age (HP:0001520)3.88196691
18Gaze-evoked nystagmus (HP:0000640)3.84373443
19Dysdiadochokinesis (HP:0002075)3.73242732
20Hyperglycemia (HP:0003074)3.69952208
21Congenital stationary night blindness (HP:0007642)3.49159190
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33164382
23Symptomatic seizures (HP:0011145)3.23952310
24Pheochromocytoma (HP:0002666)3.23445468
25Abnormality of vitamin B metabolism (HP:0004340)3.15623049
26Epileptiform EEG discharges (HP:0011182)3.11256751
27Truncal ataxia (HP:0002078)3.10742220
28EEG with generalized epileptiform discharges (HP:0011198)3.09567600
29Hyperventilation (HP:0002883)3.08330882
30Late onset (HP:0003584)3.06463703
31Central scotoma (HP:0000603)3.03280112
32Dysmetric saccades (HP:0000641)3.03167118
33Intestinal atresia (HP:0011100)2.96494993
34Ketosis (HP:0001946)2.93828299
35Dysmetria (HP:0001310)2.91309672
36Enlarged penis (HP:0000040)2.90653747
37Anxiety (HP:0000739)2.87766098
38Depression (HP:0000716)2.87743204
39Scanning speech (HP:0002168)2.85475860
40Neoplasm of the adrenal cortex (HP:0100641)2.83943286
41Increased CSF protein (HP:0002922)2.81972055
42Supranuclear gaze palsy (HP:0000605)2.79776280
43Neuroendocrine neoplasm (HP:0100634)2.79418882
44Abnormality of endocrine pancreas physiology (HP:0012093)2.76711091
45Abnormality of the pancreatic islet cells (HP:0006476)2.76711091
46Methylmalonic acidemia (HP:0002912)2.74751567
47Hemiplegia (HP:0002301)2.74482217
48Double outlet right ventricle (HP:0001719)2.66948154
49Congenital malformation of the right heart (HP:0011723)2.66948154
50Hepatic necrosis (HP:0002605)2.64328756
51Tongue fasciculations (HP:0001308)2.63943471
52Impaired smooth pursuit (HP:0007772)2.62719390
53Hypsarrhythmia (HP:0002521)2.62432189
54Abnormality of binocular vision (HP:0011514)2.58782453
55Diplopia (HP:0000651)2.58782453
56Broad-based gait (HP:0002136)2.58082236
57Hemiparesis (HP:0001269)2.57678195
58Status epilepticus (HP:0002133)2.57170661
59Hamartoma of the eye (HP:0010568)2.55123693
60Impaired social interactions (HP:0000735)2.52369148
61Abnormal social behavior (HP:0012433)2.52369148
62Hematochezia (HP:0002573)2.51178055
63Abnormality of vitamin metabolism (HP:0100508)2.50109359
64Abnormal eating behavior (HP:0100738)2.49788515
65Genetic anticipation (HP:0003743)2.48648493
66Hypokinesia (HP:0002375)2.46560691
67Urethral obstruction (HP:0000796)2.44245222
68Conjunctival hamartoma (HP:0100780)2.43739704
69Abnormality of macular pigmentation (HP:0008002)2.40959314
70Ankle clonus (HP:0011448)2.38750185
71Impaired vibration sensation in the lower limbs (HP:0002166)2.37394633
72Hypoplasia of the fovea (HP:0007750)2.37023001
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.37023001
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.34243530
75Increased CSF lactate (HP:0002490)2.31944125
76Abnormality of ocular smooth pursuit (HP:0000617)2.30036879
77Poor eye contact (HP:0000817)2.29787509
78Postural tremor (HP:0002174)2.27548806
79Insulin-resistant diabetes mellitus (HP:0000831)2.26942954
80Gait imbalance (HP:0002141)2.24706039
81Progressive inability to walk (HP:0002505)2.24614477
82Aqueductal stenosis (HP:0002410)2.24413347
83Amblyopia (HP:0000646)2.23220867
84Acute encephalopathy (HP:0006846)2.22788413
85Menstrual irregularities (HP:0000858)2.22359951
86Muscle fibrillation (HP:0010546)2.21313488
87Severe muscular hypotonia (HP:0006829)2.19657431
88Abnormal mitochondria in muscle tissue (HP:0008316)2.19632283
89Methylmalonic aciduria (HP:0012120)2.18877219
90Increased hepatocellular lipid droplets (HP:0006565)2.17162489
91Proximal tubulopathy (HP:0000114)2.15749639
92Abnormality of the renal cortex (HP:0011035)2.14962815
93Agitation (HP:0000713)2.14526904
94Bradykinesia (HP:0002067)2.13387376
95Glycosuria (HP:0003076)2.13260180
96Abnormality of urine glucose concentration (HP:0011016)2.13260180
97Abnormality of the lower motor neuron (HP:0002366)2.12907202
98Failure to thrive in infancy (HP:0001531)2.11889256
99Hepatocellular necrosis (HP:0001404)2.10757243
100Medial flaring of the eyebrow (HP:0010747)2.09864176
101Abnormal albumin level (HP:0012116)2.08686764
102Hypoalbuminemia (HP:0003073)2.08686764
103Abnormal gallbladder physiology (HP:0012438)2.08138011
104Cholecystitis (HP:0001082)2.08138011
105Congenital primary aphakia (HP:0007707)2.07592058
106Limb ataxia (HP:0002070)2.07344174
107Postural instability (HP:0002172)2.06566715
108Aplasia/hypoplasia of the uterus (HP:0008684)2.06433657
109Pancreatic islet-cell hyperplasia (HP:0004510)2.05679449
110Furrowed tongue (HP:0000221)2.04409438
111Acute necrotizing encephalopathy (HP:0006965)2.03219601
112Absent speech (HP:0001344)2.02999890
113Pancreatic cysts (HP:0001737)2.02530981
114Nephronophthisis (HP:0000090)2.01556131
115Gait ataxia (HP:0002066)2.01104461
116Pancreatic fibrosis (HP:0100732)2.00994861
117Hypomagnesemia (HP:0002917)2.00957723
118True hermaphroditism (HP:0010459)2.00533626
119Lipid accumulation in hepatocytes (HP:0006561)2.00139890
120Progressive macrocephaly (HP:0004481)1.99356350
121Muscular hypotonia of the trunk (HP:0008936)1.98133151
122Renal cortical cysts (HP:0000803)1.97771828
123Poor suck (HP:0002033)1.96814027
124Intention tremor (HP:0002080)1.95952196
125Psychosis (HP:0000709)1.94054313
126Abnormal hair whorl (HP:0010721)1.94008775
127Spastic gait (HP:0002064)1.93982180
128Drooling (HP:0002307)1.93967308
129Excessive salivation (HP:0003781)1.93967308
130Abnormality of saccadic eye movements (HP:0000570)1.93001031
131Ventricular fibrillation (HP:0001663)1.91627932
132Cortical visual impairment (HP:0100704)1.91177314
133Urinary bladder sphincter dysfunction (HP:0002839)1.88111340
134Renal Fanconi syndrome (HP:0001994)1.87331634
135Neoplasm of the peripheral nervous system (HP:0100007)1.87181413
136Delayed gross motor development (HP:0002194)1.87061065
137Nephrogenic diabetes insipidus (HP:0009806)1.86779662
138Fetal akinesia sequence (HP:0001989)1.86415578
139Abnormality of polysaccharide metabolism (HP:0011012)1.85368305
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85368305
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85368305
142Congenital sensorineural hearing impairment (HP:0008527)1.84765677
143Abnormality of the fovea (HP:0000493)1.84163648
144Neoplasm of the adrenal gland (HP:0100631)1.83526447
145Horizontal nystagmus (HP:0000666)1.83443256
146Hypoventilation (HP:0002791)1.82873766
147Generalized myoclonic seizures (HP:0002123)1.82866488
148Polyphagia (HP:0002591)1.82110950
149Respiratory failure (HP:0002878)1.81613146
150Abnormality of midbrain morphology (HP:0002418)1.81220233
151Molar tooth sign on MRI (HP:0002419)1.81220233
152Scotoma (HP:0000575)1.80947376
153Downturned corners of mouth (HP:0002714)1.80399931
154Mitochondrial inheritance (HP:0001427)1.79888471
155Neuronal loss in central nervous system (HP:0002529)1.79479460
156Prominent metopic ridge (HP:0005487)1.79153235
157Focal dystonia (HP:0004373)1.79100345
158Amelogenesis imperfecta (HP:0000705)1.77768743
159Mucopolysacchariduria (HP:0008155)1.77124030
160Urinary glycosaminoglycan excretion (HP:0003541)1.77124030
161Type II lissencephaly (HP:0007260)1.77093704
162Diminished movement (HP:0002374)1.77064589
163Oligomenorrhea (HP:0000876)1.76592922
164Spastic tetraplegia (HP:0002510)1.76253745
165Optic disc pallor (HP:0000543)1.76063233
166Cerebral edema (HP:0002181)1.74873620
167Megalencephaly (HP:0001355)1.74725964
168Testicular neoplasm (HP:0010788)1.74609001
169Torticollis (HP:0000473)1.74542609
170Resting tremor (HP:0002322)1.73423147
171Hypothermia (HP:0002045)1.73135640
172Limb dystonia (HP:0002451)1.71937193
173Abnormal rod and cone electroretinograms (HP:0008323)1.71235576
174Spinal canal stenosis (HP:0003416)1.70031331
175Hyperthyroidism (HP:0000836)1.67341822
176Impaired vibratory sensation (HP:0002495)1.67169816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.08205635
2FGFR23.93800699
3MAP3K43.44717594
4MAP2K73.16990586
5MAP3K93.06793354
6MINK13.00093420
7MST42.86470029
8GRK12.78663724
9MAP4K22.58728974
10CASK2.36473167
11MAP3K122.34264819
12PAK62.30652868
13MAP2K42.11626439
14NME12.11169630
15PRPF4B1.98042047
16PRKD31.96042494
17STK381.94693010
18INSRR1.90929458
19CAMKK21.84209797
20NEK11.83400451
21FGFR31.78879067
22GRK51.73812345
23MARK11.70088405
24NTRK21.68703002
25AKT31.67260813
26ADRBK21.66462306
27NTRK11.65941022
28WNK41.60241740
29EPHA41.59175093
30ARAF1.53364340
31KSR21.44167451
32CAMKK11.42688711
33TLK11.41035119
34PRKCG1.40795184
35STK38L1.40536761
36EIF2AK11.39918242
37PLK21.35708704
38CDK51.33783006
39CSNK1G11.31110867
40RIPK11.29340195
41ACVR1B1.27975305
42NLK1.27309129
43WNK11.21601292
44KSR11.21483080
45CSNK1G31.20624347
46DAPK11.20513525
47PNCK1.19854723
48YES11.19084484
49MAP3K131.18715041
50BMPR1B1.17188039
51FES1.16476839
52SGK2231.15651337
53SGK4941.15651337
54DAPK21.13575330
55PRKCH1.13246895
56MAP2K61.13094090
57CDK191.13029086
58PHKG21.12139146
59PHKG11.12139146
60TSSK61.11617661
61MAP3K21.10608717
62STK241.10026338
63ERBB31.09123647
64PBK1.08722945
65SGK21.07842924
66PDK31.06123528
67PDK41.06123528
68CAMK2D1.06058320
69CAMK2A1.04354631
70PINK11.01741954
71PRKCE1.01474956
72NUAK11.01461237
73STK390.99218358
74UHMK10.99134035
75DYRK1A0.98169132
76ZAK0.94295500
77MKNK20.90265536
78CAMK2B0.89995253
79TNK20.89959829
80CDK140.84955436
81CAMK10.83642884
82RIPK40.82586884
83PAK30.82335230
84BRAF0.81124130
85STK160.80507885
86EPHA30.79909652
87MAPK130.79365164
88CDK180.79327463
89FER0.78645635
90SCYL20.78016653
91SGK30.77384719
92CDK150.76486497
93CAMK2G0.75609935
94OXSR10.75498612
95STK30.75357533
96STK110.71289828
97ERBB40.70305557
98PASK0.68414382
99PLK30.66242176
100TNIK0.64759013
101PRKAA10.64545063
102CDK11A0.62861804
103PTK2B0.62318198
104CDC42BPA0.62189100
105HIPK20.61216976
106FRK0.61128832
107EIF2AK30.60681122
108PRKAA20.59707053
109TRPM70.58903630
110LMTK20.58874630
111MAP3K10.58650154
112CSNK1A1L0.58461405
113SIK30.56949091
114MUSK0.55720975
115SGK10.55131655
116BMPR20.54576170
117PRKACA0.54250724
118PRKD20.52832835
119PRKCI0.52476139
120RPS6KA30.51208969
121CDK30.50287264
122MAP2K10.50132711
123PDK10.48803349
124RET0.48102912
125NEK60.47337609
126WNK30.46071324
127CSNK1A10.45815366
128LIMK10.45810988
129PRKCA0.44551749
130MAPK100.43768788
131MARK20.43571031
132PDK20.43048689
133PRKCZ0.42607252
134PRKG20.42431258
135CSNK1G20.42308522
136CSNK1D0.41209799
137PRKCB0.40922469
138SIK20.40768647
139ROCK20.40718579
140PRKG10.39683316
141ROCK10.38561962
142PDPK10.38483671
143STK40.36269369
144TAOK10.33055345
145MYLK0.31379082
146PRKCQ0.28243146
147PRKACB0.26678547
148PTK20.22965035
149IKBKB0.21007222

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.95527150
2Nicotine addiction_Homo sapiens_hsa050333.90366035
3GABAergic synapse_Homo sapiens_hsa047273.20826934
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95914928
5Vitamin B6 metabolism_Homo sapiens_hsa007502.64335423
6Collecting duct acid secretion_Homo sapiens_hsa049662.63075632
7Morphine addiction_Homo sapiens_hsa050322.56418965
8Protein export_Homo sapiens_hsa030602.55728543
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54565307
10Circadian entrainment_Homo sapiens_hsa047132.52661407
11Insulin secretion_Homo sapiens_hsa049112.36230098
12Sulfur metabolism_Homo sapiens_hsa009202.33130921
13Glutamatergic synapse_Homo sapiens_hsa047242.30154793
14Long-term potentiation_Homo sapiens_hsa047202.18686296
15Olfactory transduction_Homo sapiens_hsa047402.13461717
16Taste transduction_Homo sapiens_hsa047422.09903718
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09903713
18Nitrogen metabolism_Homo sapiens_hsa009102.04909417
19Dopaminergic synapse_Homo sapiens_hsa047281.99719320
20Amphetamine addiction_Homo sapiens_hsa050311.99226700
21Salivary secretion_Homo sapiens_hsa049701.94352595
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94065756
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78391664
24Long-term depression_Homo sapiens_hsa047301.76845936
25Folate biosynthesis_Homo sapiens_hsa007901.76429947
26Cholinergic synapse_Homo sapiens_hsa047251.75810039
27Vibrio cholerae infection_Homo sapiens_hsa051101.74020016
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66337497
29Serotonergic synapse_Homo sapiens_hsa047261.63425664
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60360336
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53826417
32Selenocompound metabolism_Homo sapiens_hsa004501.50497704
33Fatty acid elongation_Homo sapiens_hsa000621.47979989
34Renin secretion_Homo sapiens_hsa049241.46916666
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44827776
36Gastric acid secretion_Homo sapiens_hsa049711.42668137
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41341236
38Oxidative phosphorylation_Homo sapiens_hsa001901.35807070
39Tryptophan metabolism_Homo sapiens_hsa003801.35708158
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34921081
41Type II diabetes mellitus_Homo sapiens_hsa049301.31514957
42Oxytocin signaling pathway_Homo sapiens_hsa049211.29951789
43Cocaine addiction_Homo sapiens_hsa050301.28309364
44Calcium signaling pathway_Homo sapiens_hsa040201.27255166
45Phototransduction_Homo sapiens_hsa047441.22115098
46Propanoate metabolism_Homo sapiens_hsa006401.21897156
47Peroxisome_Homo sapiens_hsa041461.20983206
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20376710
49Cardiac muscle contraction_Homo sapiens_hsa042601.19045520
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16541566
51Type I diabetes mellitus_Homo sapiens_hsa049401.13177265
52Ether lipid metabolism_Homo sapiens_hsa005651.12297362
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11305468
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.08134142
55Gap junction_Homo sapiens_hsa045401.08125830
56Sphingolipid metabolism_Homo sapiens_hsa006001.07886857
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06513933
58Pancreatic secretion_Homo sapiens_hsa049721.03927152
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03460055
60ABC transporters_Homo sapiens_hsa020101.03095175
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02765063
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02201516
63GnRH signaling pathway_Homo sapiens_hsa049121.02085419
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99957066
65Alzheimers disease_Homo sapiens_hsa050100.98556975
66Circadian rhythm_Homo sapiens_hsa047100.98466197
67cAMP signaling pathway_Homo sapiens_hsa040240.96218878
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95931002
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94573118
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.94379063
71Linoleic acid metabolism_Homo sapiens_hsa005910.93799634
72Estrogen signaling pathway_Homo sapiens_hsa049150.92283300
73Parkinsons disease_Homo sapiens_hsa050120.91846089
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.89064944
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84373508
76Thyroid hormone synthesis_Homo sapiens_hsa049180.83367261
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75605234
78beta-Alanine metabolism_Homo sapiens_hsa004100.72414612
79Arginine biosynthesis_Homo sapiens_hsa002200.71446531
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.71296115
81Butanoate metabolism_Homo sapiens_hsa006500.71284711
82Glucagon signaling pathway_Homo sapiens_hsa049220.69299074
83Retinol metabolism_Homo sapiens_hsa008300.65875307
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65316527
85Inositol phosphate metabolism_Homo sapiens_hsa005620.63558911
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63266674
87Dilated cardiomyopathy_Homo sapiens_hsa054140.63118493
88Fatty acid metabolism_Homo sapiens_hsa012120.62369623
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61413846
90Rheumatoid arthritis_Homo sapiens_hsa053230.60817424
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59364997
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59045023
93Metabolic pathways_Homo sapiens_hsa011000.58434915
94Pyruvate metabolism_Homo sapiens_hsa006200.58125433
95Melanogenesis_Homo sapiens_hsa049160.57356652
96Glioma_Homo sapiens_hsa052140.57042200
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56838368
98Huntingtons disease_Homo sapiens_hsa050160.54898674
99ErbB signaling pathway_Homo sapiens_hsa040120.53354731
100Caffeine metabolism_Homo sapiens_hsa002320.52382561
101Oocyte meiosis_Homo sapiens_hsa041140.51405092
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50788340
103Glutathione metabolism_Homo sapiens_hsa004800.50647669
104Arachidonic acid metabolism_Homo sapiens_hsa005900.49252739
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.47400132
106Bile secretion_Homo sapiens_hsa049760.46651674
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46512905
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46206985
109MAPK signaling pathway_Homo sapiens_hsa040100.44651531
110Alcoholism_Homo sapiens_hsa050340.44138047
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43680359
112Fructose and mannose metabolism_Homo sapiens_hsa000510.41868629
113Lysosome_Homo sapiens_hsa041420.41049686
114Chemical carcinogenesis_Homo sapiens_hsa052040.40131789
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39561548
116Choline metabolism in cancer_Homo sapiens_hsa052310.37256240
117mTOR signaling pathway_Homo sapiens_hsa041500.35457765
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34434192
119Axon guidance_Homo sapiens_hsa043600.33847291
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33520700
121Purine metabolism_Homo sapiens_hsa002300.33294837
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33000154
123Dorso-ventral axis formation_Homo sapiens_hsa043200.32641987
124Phagosome_Homo sapiens_hsa041450.32417800
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.32348088
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31879935
127Ovarian steroidogenesis_Homo sapiens_hsa049130.30671874
128Ras signaling pathway_Homo sapiens_hsa040140.30510702
129Regulation of autophagy_Homo sapiens_hsa041400.29929168
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29574157
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28901720
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28683625
133Endocytosis_Homo sapiens_hsa041440.28290137
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26754249
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25635288
136Insulin signaling pathway_Homo sapiens_hsa049100.24181727
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23444895
138Mineral absorption_Homo sapiens_hsa049780.21827641

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