Rank | Gene Set | Z-score |
---|---|---|
1 | sperm motility (GO:0030317) | 5.45475461 |
2 | NADH metabolic process (GO:0006734) | 5.30161677 |
3 | sperm capacitation (GO:0048240) | 5.25405994 |
4 | DNA packaging (GO:0006323) | 5.24679723 |
5 | cell wall macromolecule metabolic process (GO:0044036) | 4.89798730 |
6 | cell wall macromolecule catabolic process (GO:0016998) | 4.89798730 |
7 | fusion of sperm to egg plasma membrane (GO:0007342) | 4.84150109 |
8 | L-phenylalanine catabolic process (GO:0006559) | 4.77682033 |
9 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.77682033 |
10 | L-phenylalanine metabolic process (GO:0006558) | 4.75069962 |
11 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.75069962 |
12 | lysine catabolic process (GO:0006554) | 4.72998113 |
13 | lysine metabolic process (GO:0006553) | 4.72998113 |
14 | alpha-linolenic acid metabolic process (GO:0036109) | 4.68585871 |
15 | carnitine shuttle (GO:0006853) | 4.68107878 |
16 | sperm-egg recognition (GO:0035036) | 4.59720679 |
17 | fatty acid transmembrane transport (GO:1902001) | 4.59637989 |
18 | carnitine transport (GO:0015879) | 4.53004195 |
19 | amino-acid betaine transport (GO:0015838) | 4.53004195 |
20 | carnitine transmembrane transport (GO:1902603) | 4.52484312 |
21 | serine family amino acid catabolic process (GO:0009071) | 4.51119469 |
22 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.50873286 |
23 | amino-acid betaine metabolic process (GO:0006577) | 4.42102063 |
24 | binding of sperm to zona pellucida (GO:0007339) | 4.40125439 |
25 | glyoxylate metabolic process (GO:0046487) | 4.37422361 |
26 | acrosome reaction (GO:0007340) | 4.34107201 |
27 | sulfur amino acid catabolic process (GO:0000098) | 4.26029017 |
28 | urea cycle (GO:0000050) | 4.25795067 |
29 | urea metabolic process (GO:0019627) | 4.25795067 |
30 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.19986778 |
31 | aromatic amino acid family catabolic process (GO:0009074) | 4.16956542 |
32 | glycine metabolic process (GO:0006544) | 4.15321540 |
33 | kynurenine metabolic process (GO:0070189) | 4.14946720 |
34 | aspartate family amino acid catabolic process (GO:0009068) | 4.14862022 |
35 | sexual reproduction (GO:0019953) | 4.09075763 |
36 | cell-cell recognition (GO:0009988) | 4.07000865 |
37 | cysteine metabolic process (GO:0006534) | 4.02662119 |
38 | organic cation transport (GO:0015695) | 3.92878241 |
39 | regulation of triglyceride catabolic process (GO:0010896) | 3.90974180 |
40 | carnitine metabolic process (GO:0009437) | 3.90636389 |
41 | actin-myosin filament sliding (GO:0033275) | 3.89914100 |
42 | muscle filament sliding (GO:0030049) | 3.89914100 |
43 | acetyl-CoA metabolic process (GO:0006084) | 3.88830715 |
44 | fatty acid beta-oxidation (GO:0006635) | 3.88347606 |
45 | nitrogen cycle metabolic process (GO:0071941) | 3.87702966 |
46 | spermatid development (GO:0007286) | 3.87427458 |
47 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.86109173 |
48 | nuclear pore complex assembly (GO:0051292) | 3.76002274 |
49 | bile acid biosynthetic process (GO:0006699) | 3.75730597 |
50 | acrosome assembly (GO:0001675) | 3.75624063 |
51 | tricarboxylic acid cycle (GO:0006099) | 3.74949612 |
52 | 2-oxoglutarate metabolic process (GO:0006103) | 3.74188296 |
53 | homocysteine metabolic process (GO:0050667) | 3.71241111 |
54 | tryptophan catabolic process (GO:0006569) | 3.69222376 |
55 | indole-containing compound catabolic process (GO:0042436) | 3.69222376 |
56 | indolalkylamine catabolic process (GO:0046218) | 3.69222376 |
57 | negative regulation of fibrinolysis (GO:0051918) | 3.65135062 |
58 | skeletal muscle contraction (GO:0003009) | 3.63361098 |
59 | plasma membrane fusion (GO:0045026) | 3.62916788 |
60 | multicellular organism reproduction (GO:0032504) | 3.62427664 |
61 | serine family amino acid metabolic process (GO:0009069) | 3.61352766 |
62 | complement activation, alternative pathway (GO:0006957) | 3.60261641 |
63 | regulation of protein activation cascade (GO:2000257) | 3.59792153 |
64 | alpha-amino acid catabolic process (GO:1901606) | 3.57300761 |
65 | quaternary ammonium group transport (GO:0015697) | 3.57025214 |
66 | fatty acid catabolic process (GO:0009062) | 3.56214506 |
67 | fatty acid oxidation (GO:0019395) | 3.53320526 |
68 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.52776384 |
69 | regulation of sequestering of triglyceride (GO:0010889) | 3.50618699 |
70 | biotin metabolic process (GO:0006768) | 3.49703182 |
71 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.46704134 |
72 | lipid oxidation (GO:0034440) | 3.44586517 |
73 | triglyceride homeostasis (GO:0070328) | 3.42599758 |
74 | acylglycerol homeostasis (GO:0055090) | 3.42599758 |
75 | tryptophan metabolic process (GO:0006568) | 3.41768188 |
76 | chaperone-mediated protein complex assembly (GO:0051131) | 3.41749781 |
77 | regulation of complement activation (GO:0030449) | 3.38496694 |
78 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.37541948 |
79 | cellular amino acid catabolic process (GO:0009063) | 3.37383626 |
80 | ethanol oxidation (GO:0006069) | 3.36830293 |
81 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 3.35700414 |
82 | bile acid metabolic process (GO:0008206) | 3.34179496 |
83 | synaptonemal complex assembly (GO:0007130) | 3.33317479 |
84 | plasma lipoprotein particle clearance (GO:0034381) | 3.32385034 |
85 | regulation of fatty acid oxidation (GO:0046320) | 3.31468224 |
86 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.30002452 |
87 | reproduction (GO:0000003) | 3.29376789 |
88 | motile cilium assembly (GO:0044458) | 3.29307517 |
89 | oxaloacetate metabolic process (GO:0006107) | 3.28925352 |
90 | monocarboxylic acid catabolic process (GO:0072329) | 3.28338502 |
91 | regulation of fibrinolysis (GO:0051917) | 3.28316079 |
92 | cellular ketone body metabolic process (GO:0046950) | 3.28055921 |
93 | serine family amino acid biosynthetic process (GO:0009070) | 3.26512280 |
94 | creatine metabolic process (GO:0006600) | 3.25712607 |
95 | high-density lipoprotein particle remodeling (GO:0034375) | 3.25583348 |
96 | short-chain fatty acid metabolic process (GO:0046459) | 3.24467777 |
97 | synaptonemal complex organization (GO:0070193) | 3.23778656 |
98 | protein carboxylation (GO:0018214) | 3.23355702 |
99 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.23355702 |
100 | regulation of cilium movement (GO:0003352) | 3.22616143 |
101 | gluconeogenesis (GO:0006094) | 3.22482063 |
102 | actin-mediated cell contraction (GO:0070252) | 3.22475531 |
103 | coenzyme catabolic process (GO:0009109) | 3.21797843 |
104 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.16757094 |
105 | organic acid catabolic process (GO:0016054) | 3.15891505 |
106 | carboxylic acid catabolic process (GO:0046395) | 3.15891505 |
107 | negative regulation of fatty acid metabolic process (GO:0045922) | 3.12270660 |
108 | negative regulation of inclusion body assembly (GO:0090084) | 3.11755416 |
109 | fructose metabolic process (GO:0006000) | 3.10586072 |
110 | hexose biosynthetic process (GO:0019319) | 3.09957306 |
111 | aromatic amino acid family metabolic process (GO:0009072) | 3.09949167 |
112 | rRNA methylation (GO:0031167) | 3.09610661 |
113 | positive regulation of lipid catabolic process (GO:0050996) | 3.09592381 |
114 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.09530734 |
115 | epithelial cilium movement (GO:0003351) | 3.09155101 |
116 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 3.06270909 |
117 | regulation of cholesterol homeostasis (GO:2000188) | 3.05986378 |
118 | cellular modified amino acid catabolic process (GO:0042219) | 3.04393689 |
119 | sarcomere organization (GO:0045214) | 3.04137881 |
120 | fatty acid homeostasis (GO:0055089) | 3.02760016 |
121 | negative regulation of sterol transport (GO:0032372) | 3.01300325 |
122 | negative regulation of cholesterol transport (GO:0032375) | 3.01300325 |
123 | chromosome condensation (GO:0030261) | 3.00858915 |
124 | nuclear pore organization (GO:0006999) | 2.98121891 |
125 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.96052217 |
126 | spermatid nucleus differentiation (GO:0007289) | 2.95165271 |
127 | glycogen catabolic process (GO:0005980) | 2.94073485 |
128 | proline biosynthetic process (GO:0006561) | 2.94001231 |
129 | regulation of bile acid biosynthetic process (GO:0070857) | 2.92116398 |
130 | striated muscle contraction (GO:0006941) | 2.89099574 |
131 | glycolytic process (GO:0006096) | 2.86309735 |
132 | 4-hydroxyproline metabolic process (GO:0019471) | 2.83435538 |
133 | monosaccharide biosynthetic process (GO:0046364) | 2.82321350 |
134 | glucan catabolic process (GO:0009251) | 2.81926111 |
135 | mitotic chromosome condensation (GO:0007076) | 2.80531993 |
136 | response to muscle activity (GO:0014850) | 2.79125529 |
137 | myofibril assembly (GO:0030239) | 2.78716336 |
138 | microtubule severing (GO:0051013) | 2.76281200 |
139 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.75941367 |
140 | desmosome organization (GO:0002934) | 2.75932599 |
141 | proline metabolic process (GO:0006560) | 2.72999788 |
142 | cardiac myofibril assembly (GO:0055003) | 2.72032535 |
143 | negative regulation of histone methylation (GO:0031061) | 2.70523325 |
144 | nucleus organization (GO:0006997) | 2.69696508 |
145 | nucleosome disassembly (GO:0006337) | 2.69516612 |
146 | protein-DNA complex disassembly (GO:0032986) | 2.69516612 |
147 | protein-lipid complex assembly (GO:0065005) | 2.69067889 |
148 | phosphatidylethanolamine metabolic process (GO:0046337) | 2.69021230 |
149 | plasma lipoprotein particle assembly (GO:0034377) | 2.68976327 |
150 | diacylglycerol metabolic process (GO:0046339) | 2.66912659 |
151 | low-density lipoprotein particle clearance (GO:0034383) | 2.65932997 |
152 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.65213209 |
153 | chromatin silencing (GO:0006342) | 2.64743719 |
154 | intestinal absorption (GO:0050892) | 2.62474695 |
155 | receptor recycling (GO:0001881) | 2.62442575 |
156 | skeletal muscle adaptation (GO:0043501) | 2.62006855 |
157 | single strand break repair (GO:0000012) | 2.61341041 |
158 | cardiac muscle hypertrophy (GO:0003300) | 2.61017337 |
159 | histone H3-K9 demethylation (GO:0033169) | 2.60047082 |
160 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.59595764 |
161 | epithelial cell-cell adhesion (GO:0090136) | 2.55485712 |
162 | tricarboxylic acid metabolic process (GO:0072350) | 2.55062941 |
163 | peptidyl-lysine dimethylation (GO:0018027) | 2.55031636 |
164 | actin filament-based movement (GO:0030048) | 2.54816433 |
165 | cellular polysaccharide catabolic process (GO:0044247) | 2.54594942 |
166 | L-alpha-amino acid transmembrane transport (GO:1902475) | 2.54195280 |
167 | rRNA modification (GO:0000154) | 2.53136796 |
168 | microtubule depolymerization (GO:0007019) | 2.51999522 |
169 | cardiac muscle contraction (GO:0060048) | 2.51509427 |
170 | striated muscle hypertrophy (GO:0014897) | 2.48218965 |
171 | DNA conformation change (GO:0071103) | 2.47020117 |
172 | actomyosin structure organization (GO:0031032) | 2.46280018 |
173 | cell-substrate adherens junction assembly (GO:0007045) | 2.45874159 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 7.54651018 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.33380299 |
3 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 5.21530812 |
4 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.96436438 |
5 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 4.70159212 |
6 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.31600155 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.56509036 |
8 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.56020330 |
9 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.96448629 |
10 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.94210324 |
11 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.80876728 |
12 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.72812155 |
13 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.62361064 |
14 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.53085569 |
15 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.46847506 |
16 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.40616134 |
17 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.21059651 |
18 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.15238810 |
19 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 2.12211356 |
20 | RACK7_27058665_Chip-Seq_MCF-7_Human | 2.10129051 |
21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.08288897 |
22 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.93325846 |
23 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.88029760 |
24 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.87616706 |
25 | * ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.86917443 |
26 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.76128422 |
27 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74810875 |
28 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.74782316 |
29 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.74228263 |
30 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.71535018 |
31 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.66180755 |
32 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.66017062 |
33 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61602559 |
34 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.57919884 |
35 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.56076055 |
36 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.52388355 |
37 | * RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.47969266 |
38 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.47590035 |
39 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.44983975 |
40 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.43713370 |
41 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.40092554 |
42 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.35498031 |
43 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.34502444 |
44 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.34027869 |
45 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.33625810 |
46 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.32701424 |
47 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.32666759 |
48 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.31870905 |
49 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.29990303 |
50 | MYC_22102868_ChIP-Seq_BL_Human | 1.28788187 |
51 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.28778392 |
52 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.26698172 |
53 | KDM2B_26808549_Chip-Seq_K562_Human | 1.25385788 |
54 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.23371574 |
55 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.23353991 |
56 | * RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.23281117 |
57 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.22703034 |
58 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.20612407 |
59 | * FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.18666522 |
60 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.18178549 |
61 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.17613630 |
62 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.15662770 |
63 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.13047802 |
64 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.12804658 |
65 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.11652739 |
66 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.11499963 |
67 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.11499963 |
68 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.11173001 |
69 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.10792169 |
70 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.10511186 |
71 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.10238119 |
72 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.10191922 |
73 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.09958485 |
74 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.08319172 |
75 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.07872056 |
76 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.06554060 |
77 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.06457656 |
78 | * CLOCK_20551151_ChIP-Seq_293T_Human | 1.06139491 |
79 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.05712419 |
80 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.04648353 |
81 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.03350463 |
82 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.03224188 |
83 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 1.02993380 |
84 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.02820893 |
85 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.02786771 |
86 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.02687732 |
87 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02221995 |
88 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.02039121 |
89 | SA1_27219007_Chip-Seq_Bcells_Human | 1.01652659 |
90 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.01392942 |
91 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.01350886 |
92 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.01261941 |
93 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99898255 |
94 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.99622516 |
95 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.99185990 |
96 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.98727817 |
97 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.98618051 |
98 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.97706841 |
99 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.96563100 |
100 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.95454629 |
101 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.94383300 |
102 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.93036561 |
103 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.91991294 |
104 | P68_20966046_ChIP-Seq_HELA_Human | 0.91837644 |
105 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.90581660 |
106 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.90007316 |
107 | * NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.89980936 |
108 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.89666202 |
109 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89518064 |
110 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.89054657 |
111 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.88881755 |
112 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.88378199 |
113 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.88231196 |
114 | * SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.88193679 |
115 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.87777490 |
116 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.87733291 |
117 | * LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.87600201 |
118 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.86916708 |
119 | * SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.86642203 |
120 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.85803426 |
121 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.85703089 |
122 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.85500964 |
123 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.83928932 |
124 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.82476532 |
125 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.81656968 |
126 | * NANOG_18692474_ChIP-Seq_MEFs_Mouse | 0.81473479 |
127 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.80980612 |
128 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.79269804 |
129 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.78891326 |
130 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.78807741 |
131 | * TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.77730150 |
132 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.77585132 |
133 | ATF3_27146783_Chip-Seq_COLON_Human | 0.76385143 |
134 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.75782608 |
135 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.75721147 |
136 | KAP1_27257070_Chip-Seq_ESCs_Mouse | 0.75698684 |
137 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.75364891 |
138 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.75339481 |
139 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.75199481 |
140 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.75169025 |
141 | * NANOG_18692474_ChIP-Seq_MESCs_Mouse | 0.74771612 |
142 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.74033193 |
143 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.73983655 |
144 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.73916748 |
145 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.73134258 |
146 | * MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.72037932 |
147 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.71315830 |
148 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.70970446 |
149 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.70957921 |
150 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.69891316 |
151 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.69692777 |
152 | NANOG_16518401_ChIP-PET_MESCs_Mouse | 0.69523678 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 5.52345238 |
2 | MP0005410_abnormal_fertilization | 5.27056694 |
3 | MP0005360_urolithiasis | 5.08432074 |
4 | MP0005085_abnormal_gallbladder_physiolo | 4.58298525 |
5 | MP0005365_abnormal_bile_salt | 4.35319039 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.01874666 |
7 | MP0005670_abnormal_white_adipose | 3.23202672 |
8 | MP0008875_abnormal_xenobiotic_pharmacok | 3.12091587 |
9 | MP0003646_muscle_fatigue | 2.77773561 |
10 | MP0010329_abnormal_lipoprotein_level | 2.69425337 |
11 | MP0003252_abnormal_bile_duct | 2.64886814 |
12 | MP0002837_dystrophic_cardiac_calcinosis | 2.40850602 |
13 | MP0003705_abnormal_hypodermis_morpholog | 2.34811287 |
14 | MP0009840_abnormal_foam_cell | 2.32420944 |
15 | MP0010234_abnormal_vibrissa_follicle | 2.23888212 |
16 | MP0005332_abnormal_amino_acid | 2.17896897 |
17 | MP0005666_abnormal_adipose_tissue | 2.07349584 |
18 | MP0004145_abnormal_muscle_electrophysio | 2.02419824 |
19 | MP0004130_abnormal_muscle_cell | 1.94105539 |
20 | MP0003698_abnormal_male_reproductive | 1.91522556 |
21 | MP0004084_abnormal_cardiac_muscle | 1.87846885 |
22 | * MP0001929_abnormal_gametogenesis | 1.84950702 |
23 | MP0000678_abnormal_parathyroid_gland | 1.84817166 |
24 | MP0005083_abnormal_biliary_tract | 1.82942551 |
25 | MP0002118_abnormal_lipid_homeostasis | 1.73342158 |
26 | MP0000566_synostosis | 1.71815562 |
27 | MP0006036_abnormal_mitochondrial_physio | 1.69424540 |
28 | MP0002269_muscular_atrophy | 1.66518987 |
29 | MP0000609_abnormal_liver_physiology | 1.65998385 |
30 | MP0004264_abnormal_extraembryonic_tissu | 1.64687046 |
31 | MP0005319_abnormal_enzyme/_coenzyme | 1.62564919 |
32 | MP0005330_cardiomyopathy | 1.59364633 |
33 | MP0003693_abnormal_embryo_hatching | 1.53837513 |
34 | MP0004036_abnormal_muscle_relaxation | 1.51821114 |
35 | MP0000003_abnormal_adipose_tissue | 1.50715633 |
36 | MP0001666_abnormal_nutrient_absorption | 1.50465994 |
37 | MP0004019_abnormal_vitamin_homeostasis | 1.47044054 |
38 | MP0003195_calcinosis | 1.46164389 |
39 | MP0005409_darkened_coat_color | 1.43400887 |
40 | MP0005451_abnormal_body_composition | 1.42403764 |
41 | MP0005369_muscle_phenotype | 1.41210572 |
42 | MP0002249_abnormal_larynx_morphology | 1.39747496 |
43 | MP0000751_myopathy | 1.38299132 |
44 | MP0004185_abnormal_adipocyte_glucose | 1.37552666 |
45 | MP0004233_abnormal_muscle_weight | 1.34448129 |
46 | MP0003191_abnormal_cellular_cholesterol | 1.30898921 |
47 | MP0004087_abnormal_muscle_fiber | 1.30342452 |
48 | MP0009780_abnormal_chondrocyte_physiolo | 1.28640411 |
49 | MP0005076_abnormal_cell_differentiation | 1.26572383 |
50 | MP0002971_abnormal_brown_adipose | 1.26386791 |
51 | MP0003878_abnormal_ear_physiology | 1.26338935 |
52 | MP0005377_hearing/vestibular/ear_phenot | 1.26338935 |
53 | MP0006035_abnormal_mitochondrial_morpho | 1.21686368 |
54 | MP0004215_abnormal_myocardial_fiber | 1.20408564 |
55 | MP0001764_abnormal_homeostasis | 1.20061989 |
56 | * MP0002161_abnormal_fertility/fecundity | 1.19339518 |
57 | MP0003879_abnormal_hair_cell | 1.19222402 |
58 | MP0000733_abnormal_muscle_development | 1.16340959 |
59 | MP0010630_abnormal_cardiac_muscle | 1.15234039 |
60 | MP0005375_adipose_tissue_phenotype | 1.13936636 |
61 | MP0005266_abnormal_metabolism | 1.11288454 |
62 | MP0002210_abnormal_sex_determination | 1.11119688 |
63 | MP0003221_abnormal_cardiomyocyte_apopto | 1.08762958 |
64 | MP0003011_delayed_dark_adaptation | 1.07790080 |
65 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.06523896 |
66 | MP0006138_congestive_heart_failure | 1.05233904 |
67 | MP0000749_muscle_degeneration | 1.01195270 |
68 | MP0001145_abnormal_male_reproductive | 0.99978404 |
69 | MP0005647_abnormal_sex_gland | 0.99588992 |
70 | MP0002653_abnormal_ependyma_morphology | 0.98651539 |
71 | MP0003123_paternal_imprinting | 0.98230379 |
72 | MP0008775_abnormal_heart_ventricle | 0.97264887 |
73 | MP0002108_abnormal_muscle_morphology | 0.95328953 |
74 | MP0003077_abnormal_cell_cycle | 0.94721630 |
75 | MP0003941_abnormal_skin_development | 0.94356545 |
76 | MP0001661_extended_life_span | 0.93171532 |
77 | MP0000598_abnormal_liver_morphology | 0.93034145 |
78 | MP0001544_abnormal_cardiovascular_syste | 0.92916928 |
79 | MP0005385_cardiovascular_system_phenoty | 0.92916928 |
80 | MP0004782_abnormal_surfactant_physiolog | 0.92352480 |
81 | MP0003868_abnormal_feces_composition | 0.90030029 |
82 | MP0001730_embryonic_growth_arrest | 0.89993036 |
83 | MP0004270_analgesia | 0.89411564 |
84 | MP0003718_maternal_effect | 0.88577550 |
85 | MP0000750_abnormal_muscle_regeneration | 0.88561934 |
86 | MP0000653_abnormal_sex_gland | 0.88346433 |
87 | MP0009643_abnormal_urine_homeostasis | 0.87978356 |
88 | MP0004858_abnormal_nervous_system | 0.86610393 |
89 | MP0005620_abnormal_muscle_contractility | 0.84232974 |
90 | MP0001849_ear_inflammation | 0.82804124 |
91 | MP0001672_abnormal_embryogenesis/_devel | 0.81986919 |
92 | MP0005380_embryogenesis_phenotype | 0.81986919 |
93 | MP0009115_abnormal_fat_cell | 0.81818696 |
94 | MP0003984_embryonic_growth_retardation | 0.79708554 |
95 | MP0002088_abnormal_embryonic_growth/wei | 0.79581243 |
96 | MP0000467_abnormal_esophagus_morphology | 0.79121194 |
97 | MP0003186_abnormal_redox_activity | 0.77947098 |
98 | MP0002089_abnormal_postnatal_growth/wei | 0.77836037 |
99 | MP0009672_abnormal_birth_weight | 0.76446814 |
100 | MP0000762_abnormal_tongue_morphology | 0.76366810 |
101 | MP0000747_muscle_weakness | 0.74686036 |
102 | MP0002106_abnormal_muscle_physiology | 0.74147809 |
103 | MP0002970_abnormal_white_adipose | 0.73631147 |
104 | MP0008877_abnormal_DNA_methylation | 0.73457982 |
105 | MP0003950_abnormal_plasma_membrane | 0.73417003 |
106 | MP0002078_abnormal_glucose_homeostasis | 0.72964258 |
107 | MP0002972_abnormal_cardiac_muscle | 0.72360512 |
108 | MP0002332_abnormal_exercise_endurance | 0.72183862 |
109 | MP0002080_prenatal_lethality | 0.71908842 |
110 | MP0003566_abnormal_cell_adhesion | 0.71775592 |
111 | MP0003137_abnormal_impulse_conducting | 0.71658564 |
112 | MP0003329_amyloid_beta_deposits | 0.71535270 |
113 | MP0001348_abnormal_lacrimal_gland | 0.71063489 |
114 | MP0005376_homeostasis/metabolism_phenot | 0.70346857 |
115 | MP0003111_abnormal_nucleus_morphology | 0.69917875 |
116 | MP0005334_abnormal_fat_pad | 0.68373807 |
117 | MP0000579_abnormal_nail_morphology | 0.67398888 |
118 | MP0001765_abnormal_ion_homeostasis | 0.67314923 |
119 | MP0000534_abnormal_ureter_morphology | 0.66678750 |
120 | MP0002822_catalepsy | 0.66176669 |
121 | MP0004484_altered_response_of | 0.64820805 |
122 | MP0000537_abnormal_urethra_morphology | 0.63938739 |
123 | MP0002127_abnormal_cardiovascular_syste | 0.63760247 |
124 | MP0000759_abnormal_skeletal_muscle | 0.63655570 |
125 | MP0009697_abnormal_copulation | 0.63312869 |
126 | MP0010368_abnormal_lymphatic_system | 0.63252833 |
127 | MP0002796_impaired_skin_barrier | 0.58943318 |
128 | MP0003567_abnormal_fetal_cardiomyocyte | 0.58880550 |
129 | MP0000358_abnormal_cell_content/ | 0.57955045 |
130 | MP0002086_abnormal_extraembryonic_tissu | 0.57477693 |
131 | MP0002138_abnormal_hepatobiliary_system | 0.56904626 |
132 | MP0005395_other_phenotype | 0.56841632 |
133 | MP0010352_gastrointestinal_tract_polyps | 0.56765829 |
134 | MP0004197_abnormal_fetal_growth/weight/ | 0.56156825 |
135 | MP0001697_abnormal_embryo_size | 0.54290662 |
136 | MP0004957_abnormal_blastocyst_morpholog | 0.53603463 |
137 | MP0009053_abnormal_anal_canal | 0.53552036 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Nemaline bodies (HP:0003798) | 5.37413633 |
2 | Muscle fiber inclusion bodies (HP:0100299) | 5.37404561 |
3 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.19722523 |
4 | Intrahepatic cholestasis (HP:0001406) | 4.90091682 |
5 | Hyperglycinuria (HP:0003108) | 4.89040255 |
6 | Deep venous thrombosis (HP:0002625) | 4.84801717 |
7 | Hyperglycinemia (HP:0002154) | 4.50805377 |
8 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.39666181 |
9 | Abnormality of glycine metabolism (HP:0010895) | 4.39666181 |
10 | Hyperammonemia (HP:0001987) | 4.34869460 |
11 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.33369254 |
12 | Xanthomatosis (HP:0000991) | 4.33102453 |
13 | Hypobetalipoproteinemia (HP:0003563) | 4.24484047 |
14 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 4.22971829 |
15 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.14846996 |
16 | Absent/shortened dynein arms (HP:0200106) | 4.09135751 |
17 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.09135751 |
18 | Ketosis (HP:0001946) | 4.05773308 |
19 | Type 1 muscle fiber predominance (HP:0003803) | 4.01342545 |
20 | Myoglobinuria (HP:0002913) | 3.93478544 |
21 | Hypoalphalipoproteinemia (HP:0003233) | 3.87165129 |
22 | Hypolipoproteinemia (HP:0010981) | 3.82575053 |
23 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 3.70584426 |
24 | Hypoglycemic coma (HP:0001325) | 3.68270935 |
25 | Hyperlipoproteinemia (HP:0010980) | 3.66305951 |
26 | Hyperkalemia (HP:0002153) | 3.66210727 |
27 | Rhabdomyolysis (HP:0003201) | 3.57461867 |
28 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.51080319 |
29 | Myopathic facies (HP:0002058) | 3.49701646 |
30 | Epidermoid cyst (HP:0200040) | 3.42996400 |
31 | Complement deficiency (HP:0004431) | 3.39862287 |
32 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.39534506 |
33 | Distal lower limb muscle weakness (HP:0009053) | 3.36754179 |
34 | Prolonged partial thromboplastin time (HP:0003645) | 3.19173133 |
35 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.16149658 |
36 | EMG: myopathic abnormalities (HP:0003458) | 3.10101756 |
37 | Ketoacidosis (HP:0001993) | 3.10096224 |
38 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.09267789 |
39 | Hypercholesterolemia (HP:0003124) | 3.08905513 |
40 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.04736110 |
41 | Dicarboxylic aciduria (HP:0003215) | 3.04736110 |
42 | Infertility (HP:0000789) | 3.02853195 |
43 | Exercise-induced myalgia (HP:0003738) | 3.00884712 |
44 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.99728578 |
45 | Abnormality of serum amino acid levels (HP:0003112) | 2.96999485 |
46 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.92318212 |
47 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.90512731 |
48 | Subaortic stenosis (HP:0001682) | 2.90512731 |
49 | Exercise-induced muscle cramps (HP:0003710) | 2.88203290 |
50 | Abnormal gallbladder physiology (HP:0012438) | 2.85984045 |
51 | Cholecystitis (HP:0001082) | 2.85984045 |
52 | Male infertility (HP:0003251) | 2.82719164 |
53 | Calf muscle hypertrophy (HP:0008981) | 2.81618576 |
54 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.79553529 |
55 | Sudden death (HP:0001699) | 2.73516411 |
56 | Hyporeflexia of lower limbs (HP:0002600) | 2.70704186 |
57 | Abnormality of methionine metabolism (HP:0010901) | 2.70701763 |
58 | Neck muscle weakness (HP:0000467) | 2.69212612 |
59 | Gout (HP:0001997) | 2.64911738 |
60 | Abnormality of the lower motor neuron (HP:0002366) | 2.64516168 |
61 | Distal lower limb amyotrophy (HP:0008944) | 2.63451709 |
62 | Distal arthrogryposis (HP:0005684) | 2.59889673 |
63 | Muscle stiffness (HP:0003552) | 2.58978669 |
64 | Impulsivity (HP:0100710) | 2.57586523 |
65 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.53368411 |
66 | Abnormality of complement system (HP:0005339) | 2.50865142 |
67 | Lethargy (HP:0001254) | 2.50564306 |
68 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.50256504 |
69 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.50256504 |
70 | Chronic bronchitis (HP:0004469) | 2.50029541 |
71 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.49718957 |
72 | Progressive muscle weakness (HP:0003323) | 2.48795519 |
73 | Resting tremor (HP:0002322) | 2.48784819 |
74 | Abnormality of the calf musculature (HP:0001430) | 2.47196532 |
75 | Bundle branch block (HP:0011710) | 2.40698087 |
76 | Atrioventricular block (HP:0001678) | 2.39965116 |
77 | Ventricular tachycardia (HP:0004756) | 2.39198233 |
78 | Round ear (HP:0100830) | 2.38841576 |
79 | Increased connective tissue (HP:0009025) | 2.38354714 |
80 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.36714751 |
81 | Muscle fiber splitting (HP:0003555) | 2.36036152 |
82 | Right ventricular cardiomyopathy (HP:0011663) | 2.34282344 |
83 | Ulnar deviation of the wrist (HP:0003049) | 2.33951997 |
84 | Abnormality of glycolysis (HP:0004366) | 2.32567623 |
85 | Malnutrition (HP:0004395) | 2.31296303 |
86 | Skin nodule (HP:0200036) | 2.29898916 |
87 | Abnormality of nucleobase metabolism (HP:0010932) | 2.28755495 |
88 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.27168798 |
89 | Metabolic acidosis (HP:0001942) | 2.26616460 |
90 | Hemorrhage of the eye (HP:0011885) | 2.26081081 |
91 | Cerebral edema (HP:0002181) | 2.24472082 |
92 | Dilated cardiomyopathy (HP:0001644) | 2.24062252 |
93 | Flat acetabular roof (HP:0003180) | 2.23521465 |
94 | Fat malabsorption (HP:0002630) | 2.22366633 |
95 | Asymmetric septal hypertrophy (HP:0001670) | 2.22026621 |
96 | Abnormality of the intrinsic pathway (HP:0010989) | 2.18099267 |
97 | Abnormality of purine metabolism (HP:0004352) | 2.16449038 |
98 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.16011467 |
99 | Dysmetric saccades (HP:0000641) | 2.15690776 |
100 | Abnormal cartilage morphology (HP:0002763) | 2.14467227 |
101 | Cholelithiasis (HP:0001081) | 2.14359782 |
102 | Delayed CNS myelination (HP:0002188) | 2.14323603 |
103 | Spastic diplegia (HP:0001264) | 2.13488391 |
104 | Difficulty running (HP:0009046) | 2.12753641 |
105 | Abnormality of the common coagulation pathway (HP:0010990) | 2.11768773 |
106 | Increased purine levels (HP:0004368) | 2.11389049 |
107 | Hyperuricemia (HP:0002149) | 2.11389049 |
108 | Increased serum pyruvate (HP:0003542) | 2.11165191 |
109 | Heart block (HP:0012722) | 2.10920969 |
110 | Multiple enchondromatosis (HP:0005701) | 2.08493406 |
111 | Nasal polyposis (HP:0100582) | 2.05319040 |
112 | Ragged-red muscle fibers (HP:0003200) | 2.04184940 |
113 | Hyperglycemia (HP:0003074) | 2.04071960 |
114 | Difficulty climbing stairs (HP:0003551) | 2.03905556 |
115 | Rimmed vacuoles (HP:0003805) | 2.03229438 |
116 | Hypochromic microcytic anemia (HP:0004840) | 2.02743375 |
117 | Global brain atrophy (HP:0002283) | 2.00168292 |
118 | Abnormal gallbladder morphology (HP:0012437) | 1.98565386 |
119 | Hepatocellular carcinoma (HP:0001402) | 1.96908443 |
120 | EMG: neuropathic changes (HP:0003445) | 1.96420142 |
121 | Hyperbilirubinemia (HP:0002904) | 1.95557682 |
122 | Rhinitis (HP:0012384) | 1.94673411 |
123 | Abnormal atrioventricular conduction (HP:0005150) | 1.94569052 |
124 | Malignant hyperthermia (HP:0002047) | 1.94298826 |
125 | Increased variability in muscle fiber diameter (HP:0003557) | 1.92585011 |
126 | Progressive sensorineural hearing impairment (HP:0000408) | 1.91914253 |
127 | Joint hemorrhage (HP:0005261) | 1.89835465 |
128 | Abnormal spermatogenesis (HP:0008669) | 1.89083778 |
129 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.88973653 |
130 | Myocardial infarction (HP:0001658) | 1.88672508 |
131 | Vascular calcification (HP:0004934) | 1.88640080 |
132 | Bulbar palsy (HP:0001283) | 1.88605844 |
133 | Subcapsular cataract (HP:0000523) | 1.87835781 |
134 | Insulin resistance (HP:0000855) | 1.87040404 |
135 | Calcaneovalgus deformity (HP:0001848) | 1.86784085 |
136 | Lower limb amyotrophy (HP:0007210) | 1.86066057 |
137 | Abnormality of the salivary glands (HP:0010286) | 1.82403111 |
138 | Abnormality of the Achilles tendon (HP:0005109) | 1.82188067 |
139 | Palpitations (HP:0001962) | 1.81928573 |
140 | Hypertriglyceridemia (HP:0002155) | 1.81300961 |
141 | Achilles tendon contracture (HP:0001771) | 1.76415280 |
142 | Progressive hearing impairment (HP:0001730) | 1.73320962 |
143 | Lipoatrophy (HP:0100578) | 1.72949699 |
144 | Osteomalacia (HP:0002749) | 1.71677005 |
145 | Facial shape deformation (HP:0011334) | 1.71389481 |
146 | Potter facies (HP:0002009) | 1.71389481 |
147 | Hyponatremia (HP:0002902) | 1.69650747 |
148 | Abnormality of potassium homeostasis (HP:0011042) | 1.69335563 |
149 | Renovascular hypertension (HP:0100817) | 1.69274289 |
150 | Advanced eruption of teeth (HP:0006288) | 1.64449585 |
151 | Esophageal varix (HP:0002040) | 1.63957957 |
152 | Abnormality of carpal bone ossification (HP:0006257) | 1.61703410 |
153 | Generalized muscle weakness (HP:0003324) | 1.59557943 |
154 | Abnormal tarsal ossification (HP:0008369) | 1.58648370 |
155 | Back pain (HP:0003418) | 1.57140029 |
156 | Trismus (HP:0000211) | 1.56798926 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PDK4 | 6.07536470 |
2 | PDK3 | 6.07536470 |
3 | PDK2 | 3.82237018 |
4 | ICK | 3.74675122 |
5 | BCKDK | 3.50861502 |
6 | TESK1 | 2.95965766 |
7 | PRKD3 | 2.95631432 |
8 | TRIB3 | 2.52520657 |
9 | PKN2 | 2.49622643 |
10 | SMG1 | 2.29664765 |
11 | PLK4 | 2.25983814 |
12 | NEK1 | 2.19492612 |
13 | TTN | 1.86184781 |
14 | BRD4 | 1.71896190 |
15 | LATS1 | 1.71560691 |
16 | STK38L | 1.67789576 |
17 | STK38 | 1.67338477 |
18 | NEK2 | 1.64216215 |
19 | TTK | 1.63007361 |
20 | SIK1 | 1.61428849 |
21 | MAP3K9 | 1.54212576 |
22 | CDK12 | 1.46270278 |
23 | LATS2 | 1.41312652 |
24 | EEF2K | 1.39569354 |
25 | DMPK | 1.39053037 |
26 | PINK1 | 1.39025416 |
27 | EPHA2 | 1.36099641 |
28 | KSR2 | 1.23071685 |
29 | LMTK2 | 1.19148180 |
30 | OBSCN | 1.18793035 |
31 | NEK6 | 1.16492720 |
32 | WEE1 | 1.11896066 |
33 | NME1 | 1.11345427 |
34 | MTOR | 1.07019665 |
35 | MAP3K10 | 1.05422092 |
36 | ERN1 | 1.03639190 |
37 | FGFR4 | 1.01084435 |
38 | TYRO3 | 1.00705792 |
39 | DYRK1B | 0.97168351 |
40 | PRKAA1 | 0.97091015 |
41 | ERBB4 | 0.96694773 |
42 | PNCK | 0.94812644 |
43 | CDK4 | 0.93350410 |
44 | PHKG2 | 0.93235789 |
45 | PHKG1 | 0.93235789 |
46 | SCYL2 | 0.92791865 |
47 | RIPK1 | 0.92238080 |
48 | WNK4 | 0.91966364 |
49 | STK3 | 0.89917211 |
50 | PIK3CA | 0.88186544 |
51 | ARAF | 0.87847540 |
52 | WNK1 | 0.86286658 |
53 | PRPF4B | 0.85211938 |
54 | FLT3 | 0.84646336 |
55 | MAP3K13 | 0.83463681 |
56 | PTK2B | 0.82182188 |
57 | PBK | 0.78095283 |
58 | NME2 | 0.78024154 |
59 | CAMK1D | 0.77949017 |
60 | PDK1 | 0.75798072 |
61 | BRAF | 0.71678725 |
62 | PRKAA2 | 0.71372904 |
63 | IRAK3 | 0.69021098 |
64 | PDPK1 | 0.68957511 |
65 | MAPK11 | 0.68405611 |
66 | MET | 0.67253882 |
67 | PDGFRA | 0.65141694 |
68 | CAMK1G | 0.65059742 |
69 | FGFR3 | 0.64330038 |
70 | CDK6 | 0.63819108 |
71 | AKT3 | 0.63082341 |
72 | CHEK2 | 0.63080710 |
73 | MAPKAPK3 | 0.60483283 |
74 | MAP2K2 | 0.59903912 |
75 | MUSK | 0.58544682 |
76 | MST1R | 0.57295295 |
77 | PIK3CG | 0.57158326 |
78 | PRKG2 | 0.56449237 |
79 | DYRK3 | 0.56332357 |
80 | PLK1 | 0.55801885 |
81 | PAK2 | 0.55738965 |
82 | CDK1 | 0.52662244 |
83 | MAP2K4 | 0.52351813 |
84 | MAP3K1 | 0.49282804 |
85 | PTK6 | 0.48981956 |
86 | BRSK1 | 0.47602437 |
87 | PTK2 | 0.47597696 |
88 | CHEK1 | 0.46915381 |
89 | RPS6KA2 | 0.45703467 |
90 | STK39 | 0.45252651 |
91 | BUB1 | 0.44958994 |
92 | MAPK10 | 0.44954719 |
93 | CDC7 | 0.44882704 |
94 | MYLK | 0.44065821 |
95 | MAP3K8 | 0.44011089 |
96 | * GSK3B | 0.43576505 |
97 | MAP3K5 | 0.42869559 |
98 | CAMK2G | 0.42448158 |
99 | SRPK1 | 0.42360747 |
100 | TIE1 | 0.41715483 |
101 | TRPM7 | 0.41293235 |
102 | MAP3K6 | 0.40854486 |
103 | AKT2 | 0.40404641 |
104 | RPS6KB1 | 0.39794788 |
105 | MAP3K7 | 0.39149097 |
106 | FGFR1 | 0.38424559 |
107 | CAMK4 | 0.38407431 |
108 | CDK9 | 0.37951147 |
109 | MAP2K3 | 0.36935333 |
110 | PAK4 | 0.36166529 |
111 | RET | 0.36081289 |
112 | MAPK14 | 0.35799109 |
113 | CSNK1E | 0.35627702 |
114 | MAP2K6 | 0.34792078 |
115 | TAOK2 | 0.33885694 |
116 | MAP2K1 | 0.33463879 |
117 | BMX | 0.33345934 |
118 | PRKACG | 0.32835545 |
119 | MAP3K2 | 0.32813267 |
120 | MARK2 | 0.32001633 |
121 | ALK | 0.31292539 |
122 | AURKB | 0.31062619 |
123 | PAK3 | 0.30793292 |
124 | MAP3K3 | 0.30375164 |
125 | STK4 | 0.29990330 |
126 | CSNK1D | 0.29910880 |
127 | RPS6KB2 | 0.29400849 |
128 | GSK3A | 0.28703149 |
129 | RPS6KA1 | 0.28559051 |
130 | AURKA | 0.28521763 |
131 | ATM | 0.27686414 |
132 | ABL2 | 0.27361049 |
133 | BRSK2 | 0.27054764 |
134 | PAK1 | 0.26944200 |
135 | PRKCZ | 0.25430090 |
136 | * CDK2 | 0.23814676 |
137 | MAPK12 | 0.23603766 |
138 | CDK7 | 0.23194162 |
139 | PRKACB | 0.21852021 |
140 | PAK6 | 0.21464821 |
141 | DDR2 | 0.20145245 |
142 | TAOK1 | 0.19739179 |
143 | MELK | 0.19624977 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.19358852 |
2 | Fatty acid degradation_Homo sapiens_hsa00071 | 3.14114040 |
3 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.12012447 |
4 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 3.06555722 |
5 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.98975857 |
6 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.92259228 |
7 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.79765060 |
8 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.58997731 |
9 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.56174432 |
10 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.56156118 |
11 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.48575104 |
12 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.34589036 |
13 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.33065074 |
14 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.29419376 |
15 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.25220593 |
16 | Carbon metabolism_Homo sapiens_hsa01200 | 2.21729029 |
17 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.11705178 |
18 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.07665695 |
19 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.05891658 |
20 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.96016226 |
21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.94391825 |
22 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.89575955 |
23 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.86699488 |
24 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.77592764 |
25 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.65395971 |
26 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.63363084 |
27 | Peroxisome_Homo sapiens_hsa04146 | 1.62969677 |
28 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.56695595 |
29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.55852101 |
30 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.46442644 |
31 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.40443532 |
32 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.39988856 |
33 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.36585569 |
34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.31936837 |
35 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.30815050 |
36 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.29520711 |
37 | Bile secretion_Homo sapiens_hsa04976 | 1.29317630 |
38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.27186250 |
39 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.18453019 |
40 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.12621947 |
41 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.10652161 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.08947146 |
43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.07520128 |
44 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.07431935 |
45 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.04601147 |
46 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.03739047 |
47 | Retinol metabolism_Homo sapiens_hsa00830 | 1.01281025 |
48 | Lysine degradation_Homo sapiens_hsa00310 | 1.00344753 |
49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.99451875 |
50 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.99429250 |
51 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.99224445 |
52 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.99023043 |
53 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.97676461 |
54 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.97631101 |
55 | Thyroid cancer_Homo sapiens_hsa05216 | 0.96873203 |
56 | Histidine metabolism_Homo sapiens_hsa00340 | 0.94910468 |
57 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.93831952 |
58 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.93175885 |
59 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.88742599 |
60 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.88211952 |
61 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.87677177 |
62 | Tight junction_Homo sapiens_hsa04530 | 0.86737547 |
63 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.85149730 |
64 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.82695363 |
65 | Sulfur relay system_Homo sapiens_hsa04122 | 0.81657016 |
66 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.80497322 |
67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.78385411 |
68 | ABC transporters_Homo sapiens_hsa02010 | 0.78108881 |
69 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77261448 |
70 | Adherens junction_Homo sapiens_hsa04520 | 0.74245328 |
71 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.66434528 |
72 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.65811731 |
73 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.63649609 |
74 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.62299023 |
75 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.59914927 |
76 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.59823532 |
77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.57426835 |
78 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.52355213 |
79 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51932345 |
80 | Circadian rhythm_Homo sapiens_hsa04710 | 0.51896235 |
81 | Insulin resistance_Homo sapiens_hsa04931 | 0.51721551 |
82 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.48297305 |
83 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.47976470 |
84 | Galactose metabolism_Homo sapiens_hsa00052 | 0.47703593 |
85 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.44828221 |
86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.42861093 |
87 | Endometrial cancer_Homo sapiens_hsa05213 | 0.42279717 |
88 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.41394529 |
89 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.38372728 |
90 | DNA replication_Homo sapiens_hsa03030 | 0.38314227 |
91 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.36899558 |
92 | Long-term potentiation_Homo sapiens_hsa04720 | 0.35103721 |
93 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.34816908 |
94 | RNA transport_Homo sapiens_hsa03013 | 0.33435580 |
95 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.31803292 |
96 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.31691635 |
97 | Mineral absorption_Homo sapiens_hsa04978 | 0.31593790 |
98 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31377965 |
99 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.28169232 |
100 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.27375108 |
101 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.27128818 |
102 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.26605672 |
103 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.26191186 |
104 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.26041745 |
105 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.24750198 |
106 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.24134856 |
107 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.18672301 |
108 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.17985022 |
109 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.14287441 |
110 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.13794717 |
111 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.10169347 |
112 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.09974931 |
113 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.08775872 |
114 | Huntingtons disease_Homo sapiens_hsa05016 | 0.07567792 |
115 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.05062689 |
116 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.04838337 |
117 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.04404785 |
118 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.04375142 |
119 | Prion diseases_Homo sapiens_hsa05020 | 0.04179330 |
120 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.01709310 |
121 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.01540927 |
122 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.01331892 |
123 | Purine metabolism_Homo sapiens_hsa00230 | -0.0083440 |
124 | Pyrimidine metabolism_Homo sapiens_hsa00240 | -0.0042651 |