AKAP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72101042
2locomotory exploration behavior (GO:0035641)5.34721405
3synaptic vesicle maturation (GO:0016188)5.33416764
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31555014
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26798650
6vocalization behavior (GO:0071625)4.85060904
7synaptic vesicle exocytosis (GO:0016079)4.81632595
8regulation of synaptic vesicle exocytosis (GO:2000300)4.64210382
9protein localization to synapse (GO:0035418)4.63224776
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.58006105
11glutamate secretion (GO:0014047)4.48649687
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.42865292
13regulation of glutamate receptor signaling pathway (GO:1900449)4.36242896
14layer formation in cerebral cortex (GO:0021819)4.33064293
15L-amino acid import (GO:0043092)4.29194773
16exploration behavior (GO:0035640)4.23588707
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.22457183
18neuron cell-cell adhesion (GO:0007158)4.11718448
19cellular potassium ion homeostasis (GO:0030007)4.08492292
20cerebellar granule cell differentiation (GO:0021707)4.07007875
21regulation of synaptic vesicle transport (GO:1902803)4.05103171
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.00536209
23glutamate receptor signaling pathway (GO:0007215)3.97299874
24neurotransmitter secretion (GO:0007269)3.93772252
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89221879
26synaptic transmission, glutamatergic (GO:0035249)3.89043439
27regulation of neuronal synaptic plasticity (GO:0048168)3.87490551
28regulation of synapse structural plasticity (GO:0051823)3.85359983
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84600370
30dendritic spine morphogenesis (GO:0060997)3.81472429
31neurotransmitter-gated ion channel clustering (GO:0072578)3.79142675
32neuron-neuron synaptic transmission (GO:0007270)3.77252084
33neuronal action potential propagation (GO:0019227)3.73635083
34cellular sodium ion homeostasis (GO:0006883)3.73038657
35amino acid import (GO:0043090)3.70713014
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67279719
37sodium ion export (GO:0071436)3.63515515
38long-term memory (GO:0007616)3.62088230
39positive regulation of synapse maturation (GO:0090129)3.57030472
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54663048
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52467381
42innervation (GO:0060384)3.49945417
43proline transport (GO:0015824)3.48909918
44activation of protein kinase A activity (GO:0034199)3.46356740
45regulation of postsynaptic membrane potential (GO:0060078)3.45940369
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45899891
47cerebellar Purkinje cell differentiation (GO:0021702)3.44810366
48dendrite morphogenesis (GO:0048813)3.43401500
49positive regulation of membrane potential (GO:0045838)3.42566933
50presynaptic membrane assembly (GO:0097105)3.41561434
51regulation of dendritic spine morphogenesis (GO:0061001)3.41424500
52neuron recognition (GO:0008038)3.41149237
53negative regulation of dendrite morphogenesis (GO:0050774)3.40977688
54potassium ion import (GO:0010107)3.38628471
55synaptic vesicle endocytosis (GO:0048488)3.36329987
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.34553120
57gamma-aminobutyric acid transport (GO:0015812)3.32377704
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.29943927
59cell communication by electrical coupling (GO:0010644)3.29724950
60axonal fasciculation (GO:0007413)3.29357247
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29282472
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28672319
63presynaptic membrane organization (GO:0097090)3.27544628
64neuromuscular process controlling balance (GO:0050885)3.24291091
65membrane depolarization during action potential (GO:0086010)3.22795064
66neurotransmitter transport (GO:0006836)3.21895648
67negative regulation of neurotransmitter secretion (GO:0046929)3.21536771
68long-term synaptic potentiation (GO:0060291)3.20213575
69prepulse inhibition (GO:0060134)3.19549489
70vesicle transport along microtubule (GO:0047496)3.18486881
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18196639
72regulation of synaptic plasticity (GO:0048167)3.18059271
73regulation of neurotransmitter secretion (GO:0046928)3.15735540
74membrane hyperpolarization (GO:0060081)3.15635960
75response to histamine (GO:0034776)3.14213923
76detection of calcium ion (GO:0005513)3.13790024
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.13383324
78behavioral defense response (GO:0002209)3.09501388
79behavioral fear response (GO:0001662)3.09501388
80transmission of nerve impulse (GO:0019226)3.08790774
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08757862
82establishment of nucleus localization (GO:0040023)3.07663399
83cell communication involved in cardiac conduction (GO:0086065)3.04372576
84synapse assembly (GO:0007416)3.01320735
85regulation of ARF protein signal transduction (GO:0032012)3.00881266
86startle response (GO:0001964)3.00128085
87response to auditory stimulus (GO:0010996)2.99931238
88membrane depolarization (GO:0051899)2.99431319
89nerve growth factor signaling pathway (GO:0038180)2.98440706
90auditory behavior (GO:0031223)2.96285119
91mating behavior (GO:0007617)2.95478266
92regulation of neurotransmitter transport (GO:0051588)2.92389456
93clathrin coat assembly (GO:0048268)2.91228271
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90283852
95organelle transport along microtubule (GO:0072384)2.90048604
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89752210
97negative regulation of neurotransmitter transport (GO:0051589)2.89174615
98regulation of neurotransmitter levels (GO:0001505)2.88435652
99potassium ion homeostasis (GO:0055075)2.87816960
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.87330404
101regulation of Rac protein signal transduction (GO:0035020)2.86387068
102learning (GO:0007612)2.85965486
103fear response (GO:0042596)2.85948744
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85368874
105striatum development (GO:0021756)2.83545563
106positive regulation of dendritic spine development (GO:0060999)2.83186379
107dendritic spine organization (GO:0097061)2.82974257
108positive regulation of neurotransmitter transport (GO:0051590)2.81723599
109neuronal ion channel clustering (GO:0045161)2.81018613
110synapse organization (GO:0050808)2.80806863
111regulation of dendritic spine development (GO:0060998)2.80115706
112suckling behavior (GO:0001967)2.79819044
113regulation of vesicle fusion (GO:0031338)2.79014540
114postsynaptic membrane organization (GO:0001941)2.78160912
115neuromuscular process controlling posture (GO:0050884)2.77926608
116synaptic transmission (GO:0007268)2.77704957
117positive regulation of synaptic transmission (GO:0050806)2.77416257
118neuromuscular process (GO:0050905)2.76412602
119cell differentiation in hindbrain (GO:0021533)2.73458002
120central nervous system myelination (GO:0022010)2.72207560
121axon ensheathment in central nervous system (GO:0032291)2.72207560
122central nervous system projection neuron axonogenesis (GO:0021952)2.69497625
123regulation of voltage-gated calcium channel activity (GO:1901385)2.68717054
124positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67951929
125relaxation of cardiac muscle (GO:0055119)2.65378489
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64327183
127negative regulation of hormone biosynthetic process (GO:0032353)2.63450823
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61972734
129peptidyl-threonine phosphorylation (GO:0018107)2.60946282
130regulation of clathrin-mediated endocytosis (GO:2000369)2.58924244
131negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56388075
132regulation of Rap GTPase activity (GO:0032317)2.55837877
133nucleus localization (GO:0051647)2.53811159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09174238
2GBX2_23144817_ChIP-Seq_PC3_Human3.64953554
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81480839
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80632426
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76956654
6DROSHA_22980978_ChIP-Seq_HELA_Human2.48266266
7REST_21632747_ChIP-Seq_MESCs_Mouse2.45906512
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44791873
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44791873
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43072030
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.42701083
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37094682
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36275028
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31917329
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30246678
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26698637
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.24234628
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23060919
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14919495
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.05210741
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.01252068
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.00471882
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95669346
24* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95507974
25AR_21572438_ChIP-Seq_LNCaP_Human1.94310043
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.93509631
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.79836748
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79450539
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78398845
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76266879
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66974061
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66507465
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59194493
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54471184
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54213823
36ZNF274_21170338_ChIP-Seq_K562_Hela1.48144398
37STAT3_23295773_ChIP-Seq_U87_Human1.45733395
38* TAF15_26573619_Chip-Seq_HEK293_Human1.45655362
39SOX2_21211035_ChIP-Seq_LN229_Gbm1.45215526
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.45108155
41P300_19829295_ChIP-Seq_ESCs_Human1.43708234
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41935018
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41193749
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41036161
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40815710
46* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38122161
47AR_19668381_ChIP-Seq_PC3_Human1.36989255
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.36428149
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35745410
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35723959
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.34239136
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.33981713
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33770834
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32025820
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.31659012
56* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31267528
57* AR_25329375_ChIP-Seq_VCAP_Human1.30380988
58GATA1_22025678_ChIP-Seq_K562_Human1.28077938
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26632861
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26292491
61IGF1R_20145208_ChIP-Seq_DFB_Human1.26275447
62TCF4_23295773_ChIP-Seq_U87_Human1.25773379
63LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24828054
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24622365
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.23826709
66YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22643988
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.22549268
68TP53_16413492_ChIP-PET_HCT116_Human1.22251879
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22150408
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21961675
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21513623
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.21366067
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20922210
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19601977
75AHR_22903824_ChIP-Seq_MCF-7_Human1.19120499
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18396813
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18086657
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17439236
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15290085
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14297202
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14075024
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13832697
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13832697
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13490104
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12891490
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12489029
87* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12375954
88KDM2B_26808549_Chip-Seq_REH_Human1.11129424
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10889672
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.10348219
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09154508
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.08884967
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08631644
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.07383863
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07207907
96FUS_26573619_Chip-Seq_HEK293_Human1.07023403
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.06910652
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06060949
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04403930
100TP53_18474530_ChIP-ChIP_U2OS_Human1.03245989
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03201105
102SOX9_26525672_Chip-Seq_HEART_Mouse1.02921078
103P53_22387025_ChIP-Seq_ESCs_Mouse1.02880764
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.02781680
105RUNX2_22187159_ChIP-Seq_PCA_Human1.02454572
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02412118
107BCAT_22108803_ChIP-Seq_LS180_Human1.02409580
108KDM2B_26808549_Chip-Seq_K562_Human1.01350794
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.00940221
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00623879
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99858306
112* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99315985
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98174512
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98174512
115RNF2_27304074_Chip-Seq_NSC_Mouse0.98006766
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.96984913
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96752391
118BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96536273
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.96114906
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94877820
121* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94766447
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92461870
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91158172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09089975
2MP0003880_abnormal_central_pattern4.20722060
3MP0003635_abnormal_synaptic_transmissio3.95038422
4MP0004270_analgesia3.86387882
5MP0002063_abnormal_learning/memory/cond3.21229140
6MP0009745_abnormal_behavioral_response3.16558076
7MP0008057_abnormal_DNA_replication2.99632749
8MP0002064_seizures2.88896195
9MP0009046_muscle_twitch2.88895885
10MP0001968_abnormal_touch/_nociception2.85778243
11MP0002822_catalepsy2.71398357
12MP0005423_abnormal_somatic_nervous2.70973959
13MP0002572_abnormal_emotion/affect_behav2.64874282
14MP0002734_abnormal_mechanical_nocicepti2.56625512
15MP0001486_abnormal_startle_reflex2.53605871
16MP0002272_abnormal_nervous_system2.47205922
17MP0009780_abnormal_chondrocyte_physiolo2.31373612
18MP0002735_abnormal_chemical_nociception2.14201601
19MP0002909_abnormal_adrenal_gland1.99885562
20MP0002736_abnormal_nociception_after1.96831907
21MP0005551_abnormal_eye_electrophysiolog1.93184196
22MP0002067_abnormal_sensory_capabilities1.92282208
23MP0001501_abnormal_sleep_pattern1.91944832
24MP0001440_abnormal_grooming_behavior1.88061853
25MP0002184_abnormal_innervation1.84141712
26MP0002733_abnormal_thermal_nociception1.81793265
27MP0000569_abnormal_digit_pigmentation1.80227816
28MP0004924_abnormal_behavior1.78174377
29MP0005386_behavior/neurological_phenoty1.78174377
30MP0000778_abnormal_nervous_system1.77618336
31MP0001970_abnormal_pain_threshold1.76121387
32MP0004811_abnormal_neuron_physiology1.75421309
33MP0008569_lethality_at_weaning1.70500830
34MP0004858_abnormal_nervous_system1.68243050
35MP0002557_abnormal_social/conspecific_i1.67602148
36MP0001984_abnormal_olfaction1.65996386
37MP0008877_abnormal_DNA_methylation1.61622290
38MP0000955_abnormal_spinal_cord1.58223826
39MP0003787_abnormal_imprinting1.57943369
40MP0005646_abnormal_pituitary_gland1.51934376
41MP0003329_amyloid_beta_deposits1.50737903
42MP0002882_abnormal_neuron_morphology1.49459830
43MP0004885_abnormal_endolymph1.47472051
44MP0006276_abnormal_autonomic_nervous1.46173849
45MP0003879_abnormal_hair_cell1.43299613
46MP0003633_abnormal_nervous_system1.35442438
47MP0002009_preneoplasia1.34494461
48MP0002066_abnormal_motor_capabilities/c1.33178664
49MP0003122_maternal_imprinting1.31367938
50MP0005645_abnormal_hypothalamus_physiol1.29521732
51MP0001502_abnormal_circadian_rhythm1.29396542
52MP0003123_paternal_imprinting1.24925478
53MP0003283_abnormal_digestive_organ1.19897146
54MP0000013_abnormal_adipose_tissue1.19693474
55MP0003890_abnormal_embryonic-extraembry1.19390988
56MP0006072_abnormal_retinal_apoptosis1.18491615
57MP0002229_neurodegeneration1.16904304
58MP0002090_abnormal_vision1.15196428
59MP0002152_abnormal_brain_morphology1.13700185
60MP0001348_abnormal_lacrimal_gland1.13143954
61MP0003631_nervous_system_phenotype1.12962109
62MP0001529_abnormal_vocalization1.08312363
63MP0000751_myopathy1.06899099
64MP0004233_abnormal_muscle_weight1.05486527
65MP0004145_abnormal_muscle_electrophysio1.05292245
66MP0003868_abnormal_feces_composition1.03865897
67MP0008961_abnormal_basal_metabolism1.03658686
68MP0010386_abnormal_urinary_bladder1.03592260
69MP0001177_atelectasis1.00896902
70MP0003183_abnormal_peptide_metabolism1.00530931
71MP0002877_abnormal_melanocyte_morpholog1.00132925
72MP0005253_abnormal_eye_physiology0.96793624
73MP0001299_abnormal_eye_distance/0.96496622
74MP0000631_abnormal_neuroendocrine_gland0.94337797
75MP0004142_abnormal_muscle_tone0.92121114
76MP0004085_abnormal_heartbeat0.90925801
77MP0003634_abnormal_glial_cell0.90183556
78MP0005187_abnormal_penis_morphology0.88388583
79MP0005623_abnormal_meninges_morphology0.88119628
80MP0001188_hyperpigmentation0.87331963
81MP0002069_abnormal_eating/drinking_beha0.87261166
82MP0004742_abnormal_vestibular_system0.86745993
83MP0002752_abnormal_somatic_nervous0.86368526
84MP0003632_abnormal_nervous_system0.84253794
85MP0004215_abnormal_myocardial_fiber0.83059098
86MP0010234_abnormal_vibrissa_follicle0.82380814
87MP0010352_gastrointestinal_tract_polyps0.79175132
88MP0003045_fibrosis0.75794943
89MP0005394_taste/olfaction_phenotype0.75328813
90MP0005499_abnormal_olfactory_system0.75328813
91MP0003690_abnormal_glial_cell0.74388624
92MP0001905_abnormal_dopamine_level0.73052323
93MP0008874_decreased_physiological_sensi0.72119432
94MP0004134_abnormal_chest_morphology0.72094610
95MP0008872_abnormal_physiological_respon0.71065529
96MP0010678_abnormal_skin_adnexa0.70677550
97MP0003091_abnormal_cell_migration0.70376067
98MP0001963_abnormal_hearing_physiology0.68583282
99MP0004043_abnormal_pH_regulation0.68561478
100MP0003137_abnormal_impulse_conducting0.67008966
101MP0005535_abnormal_body_temperature0.66229311
102MP0002837_dystrophic_cardiac_calcinosis0.65451959
103MP0003861_abnormal_nervous_system0.64657023
104MP0005195_abnormal_posterior_eye0.64132619
105MP0000920_abnormal_myelination0.64101111
106MP0010769_abnormal_survival0.63914447
107MP0010770_preweaning_lethality0.62792762
108MP0002082_postnatal_lethality0.62792762
109MP0003121_genomic_imprinting0.62661377
110MP0001943_abnormal_respiration0.60879912
111MP0001485_abnormal_pinna_reflex0.60832959
112MP0010768_mortality/aging0.60131287
113MP0004147_increased_porphyrin_level0.59272366
114MP0000534_abnormal_ureter_morphology0.59094899
115MP0002638_abnormal_pupillary_reflex0.58616347
116MP0000427_abnormal_hair_cycle0.56881534
117MP0000462_abnormal_digestive_system0.56683426
118MP0005409_darkened_coat_color0.56278342
119MP0003172_abnormal_lysosome_physiology0.54263131
120MP0005174_abnormal_tail_pigmentation0.53962988
121MP0000604_amyloidosis0.53693571
122MP0003385_abnormal_body_wall0.52572411
123MP0000383_abnormal_hair_follicle0.51824099
124MP0004130_abnormal_muscle_cell0.51820413

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.29551618
2Myokymia (HP:0002411)5.68937238
3Focal seizures (HP:0007359)5.02746014
4Epileptic encephalopathy (HP:0200134)4.30226032
5Visual hallucinations (HP:0002367)4.24677326
6Progressive cerebellar ataxia (HP:0002073)4.05515208
7Action tremor (HP:0002345)4.04706178
8Febrile seizures (HP:0002373)3.94774259
9Absence seizures (HP:0002121)3.82521652
10Atonic seizures (HP:0010819)3.77168381
11Papillary thyroid carcinoma (HP:0002895)3.73057426
12Dialeptic seizures (HP:0011146)3.42528793
13Generalized tonic-clonic seizures (HP:0002069)3.36523263
14Truncal ataxia (HP:0002078)3.25445015
15Gaze-evoked nystagmus (HP:0000640)3.18546280
16Dysdiadochokinesis (HP:0002075)3.14334690
17Ankle clonus (HP:0011448)3.14123728
18Impaired vibration sensation in the lower limbs (HP:0002166)3.13223423
19Papilledema (HP:0001085)3.12822535
20Urinary bladder sphincter dysfunction (HP:0002839)3.10117876
21Broad-based gait (HP:0002136)3.04165289
22Obstructive sleep apnea (HP:0002870)2.99787794
23Depression (HP:0000716)2.99600138
24Supranuclear gaze palsy (HP:0000605)2.96201628
25Poor eye contact (HP:0000817)2.95940139
26Excessive salivation (HP:0003781)2.90219480
27Drooling (HP:0002307)2.90219480
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87518326
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.87518326
30Abnormal social behavior (HP:0012433)2.80210032
31Impaired social interactions (HP:0000735)2.80210032
32Abnormality of the lower motor neuron (HP:0002366)2.75838981
33Postural instability (HP:0002172)2.74158255
34Dysmetria (HP:0001310)2.72464456
35Genetic anticipation (HP:0003743)2.70232563
36Central scotoma (HP:0000603)2.69692424
37Hyperventilation (HP:0002883)2.67774892
38Termporal pattern (HP:0011008)2.65350999
39Insidious onset (HP:0003587)2.65350999
40Urinary urgency (HP:0000012)2.64116555
41Impaired smooth pursuit (HP:0007772)2.63659926
42Scanning speech (HP:0002168)2.63189592
43Epileptiform EEG discharges (HP:0011182)2.62517781
44Congenital stationary night blindness (HP:0007642)2.61291091
45Overgrowth (HP:0001548)2.58225812
46Anxiety (HP:0000739)2.57574629
47EEG with generalized epileptiform discharges (HP:0011198)2.54990891
48Dysmetric saccades (HP:0000641)2.52482507
49Thickened helices (HP:0000391)2.47580473
50Spastic gait (HP:0002064)2.46716217
51Mutism (HP:0002300)2.43361497
52Heterotopia (HP:0002282)2.42007799
53Abnormality of ocular smooth pursuit (HP:0000617)2.41167494
54Intention tremor (HP:0002080)2.39163367
55Amblyopia (HP:0000646)2.34874430
56Hypsarrhythmia (HP:0002521)2.32940496
57Macroorchidism (HP:0000053)2.27249332
58Torticollis (HP:0000473)2.23687549
59Hemiparesis (HP:0001269)2.23484620
60Abnormality of the corticospinal tract (HP:0002492)2.23304151
61Menstrual irregularities (HP:0000858)2.21517053
62Bradykinesia (HP:0002067)2.21447586
63Abnormal eating behavior (HP:0100738)2.21164488
64Hemiplegia (HP:0002301)2.20597901
65Agitation (HP:0000713)2.19163090
66Thyroid carcinoma (HP:0002890)2.19030106
67Pheochromocytoma (HP:0002666)2.17568810
68Abnormality of macular pigmentation (HP:0008002)2.17174725
69Megalencephaly (HP:0001355)2.16532162
70Cerebral inclusion bodies (HP:0100314)2.15270359
71Mild short stature (HP:0003502)2.14818229
72Lower limb muscle weakness (HP:0007340)2.12058868
73Impaired vibratory sensation (HP:0002495)2.10383248
74Stereotypic behavior (HP:0000733)2.10071865
75Absent speech (HP:0001344)2.09478755
76Protruding tongue (HP:0010808)2.09292527
77Limb dystonia (HP:0002451)2.05595288
78Resting tremor (HP:0002322)2.04775426
79Truncal obesity (HP:0001956)2.03044457
80Insomnia (HP:0100785)2.02092875
81Pointed chin (HP:0000307)2.01489761
82Neurofibrillary tangles (HP:0002185)2.00658923
83Fetal akinesia sequence (HP:0001989)2.00125182
84Ankyloglossia (HP:0010296)1.97241744
85Blue irides (HP:0000635)1.96612843
86Bundle branch block (HP:0011710)1.94191583
87Focal dystonia (HP:0004373)1.92239113
88Volvulus (HP:0002580)1.91583228
89Cubitus valgus (HP:0002967)1.91059445
90Progressive inability to walk (HP:0002505)1.90822663
91Prolonged QT interval (HP:0001657)1.90573693
92Abnormality of saccadic eye movements (HP:0000570)1.89352249
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87628320
94Clonus (HP:0002169)1.86991414
95Abnormality of binocular vision (HP:0011514)1.86673146
96Diplopia (HP:0000651)1.86673146
97Increased circulating renin level (HP:0000848)1.86436668
98Aqueductal stenosis (HP:0002410)1.82389936
99Ventricular fibrillation (HP:0001663)1.82196258
100Abnormality of salivation (HP:0100755)1.81575685
101Gait ataxia (HP:0002066)1.79729170
102Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79483648
103Akinesia (HP:0002304)1.78960553
104Vertebral arch anomaly (HP:0008438)1.78570207
105Neoplasm of the heart (HP:0100544)1.78062349
106Hypoventilation (HP:0002791)1.77887590
107Relative macrocephaly (HP:0004482)1.77695271
108Scotoma (HP:0000575)1.77572196
109Neuroendocrine neoplasm (HP:0100634)1.77491108
110Inappropriate behavior (HP:0000719)1.77323182
111Deeply set eye (HP:0000490)1.76812794
112Morphological abnormality of the pyramidal tract (HP:0002062)1.76394171
113Lower limb asymmetry (HP:0100559)1.76359438
114Amyotrophic lateral sclerosis (HP:0007354)1.75463181
115Postural tremor (HP:0002174)1.75309599
116Status epilepticus (HP:0002133)1.75258542
117Abnormal EKG (HP:0003115)1.74657135
118Generalized hypopigmentation of hair (HP:0011358)1.73716937
119Craniofacial dystonia (HP:0012179)1.72892147
120Paraplegia (HP:0010550)1.72281254
121Hammertoe (HP:0001765)1.70540441
122Spastic paraplegia (HP:0001258)1.70377550
123Widely spaced teeth (HP:0000687)1.69950549
124Hepatoblastoma (HP:0002884)1.69789962
125Obsessive-compulsive behavior (HP:0000722)1.69011711
126Sleep apnea (HP:0010535)1.68931085
127Intellectual disability, profound (HP:0002187)1.68537220
128Open mouth (HP:0000194)1.67613167
129Decreased motor nerve conduction velocity (HP:0003431)1.65593080
130Generalized myoclonic seizures (HP:0002123)1.65041028
131Incomplete penetrance (HP:0003829)1.64687887
132Neuronal loss in central nervous system (HP:0002529)1.64223736
133Lower limb amyotrophy (HP:0007210)1.64036573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.54391771
2EPHA43.95868686
3MAP3K93.52045341
4MARK13.26101763
5MAP3K43.04211146
6MINK12.50615434
7PAK62.33308531
8NTRK12.17712641
9PRKD32.17655098
10NTRK22.12879701
11MAP2K72.10899832
12KSR22.08497409
13DAPK21.97920481
14AKT31.86799499
15CAMKK11.76606769
16MAP2K41.75381648
17CDK121.74116389
18KSR11.72744582
19CDK51.48863321
20MAP3K21.43744711
21STK381.40837730
22PRPF4B1.37081903
23SIK21.35213271
24CASK1.28660361
25MAPK131.24765381
26PHKG11.21591135
27PHKG21.21591135
28RIPK41.21049622
29PNCK1.19831153
30CAMKK21.19073322
31DAPK11.19055982
32NEK61.17420826
33TNIK1.17288423
34RET1.16956956
35CAMK1G1.15607593
36FGFR31.12078913
37SGK2231.11490617
38SGK4941.11490617
39TYRO31.09806150
40PLK21.08216428
41BRD41.07930197
42PRKCG1.05934432
43SGK21.04387224
44STK391.02440906
45RIPK11.02348655
46UHMK11.01938509
47SCYL21.00299226
48WNK31.00233877
49PAK30.98924130
50FES0.97459899
51FGFR20.93722505
52LATS20.93532333
53CAMK2A0.93395480
54PDGFRB0.93165574
55PRKCH0.92888761
56GRK50.92776839
57SGK30.92303883
58MAP3K120.90357175
59STK110.86250035
60LMTK20.83042406
61MAP3K130.82725450
62SGK10.82542083
63YES10.80857823
64WNK10.80316988
65CAMK10.79454208
66JAK10.78779669
67TAOK10.77072946
68CDK140.76507768
69EEF2K0.76326523
70MARK20.75440566
71CSNK1G20.75213961
72CDK180.74653700
73CDK150.74028929
74PINK10.72812812
75CAMK2B0.72062593
76BMPR20.70623901
77DYRK1A0.70243610
78CAMK1D0.67781142
79FRK0.67502331
80RPS6KB10.66983984
81ALK0.66901193
82NEK90.66853245
83FER0.65703804
84CDC42BPA0.65580876
85INSRR0.64468772
86TAF10.63195370
87PDGFRA0.62546249
88PTK2B0.61660272
89CDK11A0.61213837
90CAMK2D0.60386656
91RPS6KA30.60329258
92MAPK100.59742072
93MAP3K70.58890360
94RAF10.57424694
95MAP3K10.57149776
96TRPM70.56984096
97PIK3CA0.55377699
98CAMK40.54625323
99STK38L0.54372434
100PRKCZ0.54351173
101NEK10.53593965
102PDK10.52827364
103MET0.52765409
104PRKCE0.51808216
105CSNK1D0.50979007
106CDK190.50508134
107ROCK20.50292730
108FYN0.47279854
109OXSR10.46765279
110MAPK120.46340816
111ICK0.46307070
112PDPK10.45831431
113TNK20.44127074
114DDR20.44074967
115ARAF0.43635435
116MAP3K60.43249840
117LATS10.43249362
118PRKCB0.41429056
119DMPK0.39042678
120BRAF0.37897880
121ERBB30.35821260
122CSNK1E0.35701094
123MAP2K10.34551693

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48683893
2Synaptic vesicle cycle_Homo sapiens_hsa047212.84086782
3GABAergic synapse_Homo sapiens_hsa047272.70721902
4Circadian entrainment_Homo sapiens_hsa047132.61246907
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56172138
6Olfactory transduction_Homo sapiens_hsa047402.51832092
7Long-term potentiation_Homo sapiens_hsa047202.48705788
8Morphine addiction_Homo sapiens_hsa050322.48003672
9Glutamatergic synapse_Homo sapiens_hsa047242.44864581
10Amphetamine addiction_Homo sapiens_hsa050312.18524701
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16200933
12Insulin secretion_Homo sapiens_hsa049112.13263591
13Dopaminergic synapse_Homo sapiens_hsa047282.10726264
14Salivary secretion_Homo sapiens_hsa049702.01914504
15Cholinergic synapse_Homo sapiens_hsa047251.95848038
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80022862
17Renin secretion_Homo sapiens_hsa049241.77009832
18Gastric acid secretion_Homo sapiens_hsa049711.73995927
19Taste transduction_Homo sapiens_hsa047421.73221821
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64660037
21Cocaine addiction_Homo sapiens_hsa050301.62727231
22Oxytocin signaling pathway_Homo sapiens_hsa049211.61596228
23Phototransduction_Homo sapiens_hsa047441.60894273
24Serotonergic synapse_Homo sapiens_hsa047261.57556156
25Long-term depression_Homo sapiens_hsa047301.53251133
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49261103
27Calcium signaling pathway_Homo sapiens_hsa040201.49084341
28Type II diabetes mellitus_Homo sapiens_hsa049301.43261124
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36562920
30GnRH signaling pathway_Homo sapiens_hsa049121.36533581
31Gap junction_Homo sapiens_hsa045401.33437979
32Nitrogen metabolism_Homo sapiens_hsa009101.32691951
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28887937
34cAMP signaling pathway_Homo sapiens_hsa040241.28876177
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27736989
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23643452
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20389744
38Estrogen signaling pathway_Homo sapiens_hsa049151.19404554
39Glioma_Homo sapiens_hsa052141.16930905
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14232405
41Axon guidance_Homo sapiens_hsa043601.13940808
42Dorso-ventral axis formation_Homo sapiens_hsa043201.08252805
43ErbB signaling pathway_Homo sapiens_hsa040121.03929704
44Melanogenesis_Homo sapiens_hsa049160.99471413
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.95075056
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91439773
47Collecting duct acid secretion_Homo sapiens_hsa049660.91168064
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.90111299
49Dilated cardiomyopathy_Homo sapiens_hsa054140.89652732
50Pancreatic secretion_Homo sapiens_hsa049720.89372477
51Thyroid hormone synthesis_Homo sapiens_hsa049180.85972566
52Oocyte meiosis_Homo sapiens_hsa041140.85055240
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84429024
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81068757
55mTOR signaling pathway_Homo sapiens_hsa041500.80053563
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79116839
57Choline metabolism in cancer_Homo sapiens_hsa052310.75720517
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74017794
59Adherens junction_Homo sapiens_hsa045200.72998972
60Glucagon signaling pathway_Homo sapiens_hsa049220.72046302
61Circadian rhythm_Homo sapiens_hsa047100.70905439
62MAPK signaling pathway_Homo sapiens_hsa040100.69934459
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68586880
64Cardiac muscle contraction_Homo sapiens_hsa042600.66283290
65Vibrio cholerae infection_Homo sapiens_hsa051100.65653244
66Alcoholism_Homo sapiens_hsa050340.65269301
67Endometrial cancer_Homo sapiens_hsa052130.65188194
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64641836
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.64415332
70Bile secretion_Homo sapiens_hsa049760.62400372
71Inositol phosphate metabolism_Homo sapiens_hsa005620.61195704
72Chronic myeloid leukemia_Homo sapiens_hsa052200.60764052
73Focal adhesion_Homo sapiens_hsa045100.59355306
74Rap1 signaling pathway_Homo sapiens_hsa040150.59184133
75Ras signaling pathway_Homo sapiens_hsa040140.58925393
76Vitamin B6 metabolism_Homo sapiens_hsa007500.58161937
77MicroRNAs in cancer_Homo sapiens_hsa052060.56633751
78FoxO signaling pathway_Homo sapiens_hsa040680.56610412
79Renal cell carcinoma_Homo sapiens_hsa052110.55530398
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55135574
81Proteoglycans in cancer_Homo sapiens_hsa052050.54618174
82B cell receptor signaling pathway_Homo sapiens_hsa046620.54575457
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54263395
84VEGF signaling pathway_Homo sapiens_hsa043700.53905440
85Wnt signaling pathway_Homo sapiens_hsa043100.52359353
86Insulin signaling pathway_Homo sapiens_hsa049100.51686837
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51495294
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51420791
89Non-small cell lung cancer_Homo sapiens_hsa052230.51308418
90Fatty acid biosynthesis_Homo sapiens_hsa000610.50770802
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50348819
92Pancreatic cancer_Homo sapiens_hsa052120.49568040
93Melanoma_Homo sapiens_hsa052180.48872887
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48782882
95Hippo signaling pathway_Homo sapiens_hsa043900.48643962
96Endocytosis_Homo sapiens_hsa041440.47049468
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.46591510
98Prostate cancer_Homo sapiens_hsa052150.46561494
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46194441
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45361536
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44583012
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44450568
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44223437
104Ovarian steroidogenesis_Homo sapiens_hsa049130.42510306
105Colorectal cancer_Homo sapiens_hsa052100.39876448
106Type I diabetes mellitus_Homo sapiens_hsa049400.39712980
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39320991
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.39034097
109Prion diseases_Homo sapiens_hsa050200.37106776
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29952596
111Chemokine signaling pathway_Homo sapiens_hsa040620.29392725
112Prolactin signaling pathway_Homo sapiens_hsa049170.28415990
113Tight junction_Homo sapiens_hsa045300.28356153
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26830810
115Hedgehog signaling pathway_Homo sapiens_hsa043400.25678852
116AMPK signaling pathway_Homo sapiens_hsa041520.25597619
117Platelet activation_Homo sapiens_hsa046110.25290148

Most similar genes based on co-expression Upload to Enrichr

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