AKAP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.67681664
2cilium or flagellum-dependent cell motility (GO:0001539)8.53548396
3sperm-egg recognition (GO:0035036)8.40377611
4acrosome reaction (GO:0007340)8.27681382
5multicellular organism reproduction (GO:0032504)7.83941392
6plasma membrane fusion (GO:0045026)7.82048159
7binding of sperm to zona pellucida (GO:0007339)7.80313292
8acrosome assembly (GO:0001675)7.61797482
9cell-cell recognition (GO:0009988)7.44090661
10cell wall macromolecule metabolic process (GO:0044036)7.35326826
11cell wall macromolecule catabolic process (GO:0016998)7.35326826
12spermatid development (GO:0007286)7.29643206
13epithelial cilium movement (GO:0003351)7.23999099
14axonemal dynein complex assembly (GO:0070286)7.07747139
15regulation of cilium movement (GO:0003352)6.67021297
16motile cilium assembly (GO:0044458)6.55738192
17reproduction (GO:0000003)6.54154170
18piRNA metabolic process (GO:0034587)6.22799226
19synaptonemal complex organization (GO:0070193)6.12644512
20synaptonemal complex assembly (GO:0007130)5.99217139
21male meiosis (GO:0007140)5.96334075
22cilium movement (GO:0003341)5.92702860
23microtubule depolymerization (GO:0007019)5.52164322
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.51295533
25nuclear pore complex assembly (GO:0051292)5.39197424
26single fertilization (GO:0007338)5.38359560
27sperm capacitation (GO:0048240)4.91712520
28spermatogenesis (GO:0007283)4.86236698
29male gamete generation (GO:0048232)4.84816855
30nuclear pore organization (GO:0006999)4.81274103
31fertilization (GO:0009566)4.80921916
32negative regulation of inclusion body assembly (GO:0090084)4.59257451
33germ cell development (GO:0007281)4.49072134
34gamete generation (GO:0007276)4.47361713
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.38066039
36regulation of microtubule-based movement (GO:0060632)4.29124708
37ventricular system development (GO:0021591)4.28860850
38male meiosis I (GO:0007141)4.27247357
39chromosome organization involved in meiosis (GO:0070192)4.15048240
40chaperone-mediated protein complex assembly (GO:0051131)4.13137457
41pore complex assembly (GO:0046931)4.06994672
42regulation of inclusion body assembly (GO:0090083)4.02846844
43chromosome condensation (GO:0030261)4.02638833
44cell adhesion mediated by integrin (GO:0033627)3.93803948
45meiotic nuclear division (GO:0007126)3.89762725
46DNA methylation involved in gamete generation (GO:0043046)3.86850308
47peptidyl-threonine dephosphorylation (GO:0035970)3.84478143
48DNA packaging (GO:0006323)3.81462458
49mitotic sister chromatid cohesion (GO:0007064)3.73646433
50left/right pattern formation (GO:0060972)3.71357017
51lung vasculature development (GO:0060426)3.68812343
52organic cation transport (GO:0015695)3.68206259
53paraxial mesoderm development (GO:0048339)3.66405030
54monoubiquitinated protein deubiquitination (GO:0035520)3.65007986
55genitalia morphogenesis (GO:0035112)3.64756833
56heterochromatin organization (GO:0070828)3.63142065
57chondrocyte proliferation (GO:0035988)3.59410268
58multicellular organismal reproductive process (GO:0048609)3.59404470
59regulation of histone H3-K9 methylation (GO:0051570)3.57873574
60regulation of centriole replication (GO:0046599)3.55207578
61DNA replication-dependent nucleosome assembly (GO:0006335)3.55156877
62DNA replication-dependent nucleosome organization (GO:0034723)3.55156877
63seminiferous tubule development (GO:0072520)3.52476945
64meiosis I (GO:0007127)3.51034288
65microtubule severing (GO:0051013)3.48069290
66retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47829992
67cell recognition (GO:0008037)3.45921922
68negative regulation of DNA repair (GO:0045738)3.42619092
69keratinocyte proliferation (GO:0043616)3.42379194
70skin morphogenesis (GO:0043589)3.41594278
71gene silencing by RNA (GO:0031047)3.39538149
72establishment of integrated proviral latency (GO:0075713)3.36631167
73negative regulation of chondrocyte differentiation (GO:0032331)3.30579631
74regulation of mitotic spindle organization (GO:0060236)3.28934018
75negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.27656979
76calcium ion-dependent exocytosis (GO:0017156)3.24183267
77endothelial cell morphogenesis (GO:0001886)3.23354322
78hippo signaling (GO:0035329)3.20805983
79negative regulation of organelle assembly (GO:1902116)3.19037287
80nucleus organization (GO:0006997)3.17793976
81regulation of protein polyubiquitination (GO:1902914)3.16723561
82notochord development (GO:0030903)3.16091555
83regulation of pigment cell differentiation (GO:0050932)3.09507711
84regulation of meiosis I (GO:0060631)3.08331878
85regulation of spindle checkpoint (GO:0090231)3.06501165
86protein polyglutamylation (GO:0018095)3.06018858
87regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.04045486
88protein refolding (GO:0042026)3.04037696
89protein localization to chromosome, centromeric region (GO:0071459)3.03011121
90mitotic cytokinesis (GO:0000281)3.01373455
91mesodermal cell differentiation (GO:0048333)2.99489244
92meiotic cell cycle (GO:0051321)2.99051583
93glomerular visceral epithelial cell development (GO:0072015)2.98435199
94mesenchymal-epithelial cell signaling (GO:0060638)2.94501925
95multicellular organismal development (GO:0007275)2.94093260
96regulation of RNA export from nucleus (GO:0046831)2.92717499
97meiotic cell cycle process (GO:1903046)2.91859645
98lymphangiogenesis (GO:0001946)2.91796425
99gene silencing (GO:0016458)2.91788318
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91616050
101microtubule polymerization or depolymerization (GO:0031109)2.90026271
102establishment of apical/basal cell polarity (GO:0035089)2.89853408
103glycerol ether metabolic process (GO:0006662)2.89484817
104regulation of gene silencing by RNA (GO:0060966)2.88417649
105regulation of posttranscriptional gene silencing (GO:0060147)2.88417649
106regulation of gene silencing by miRNA (GO:0060964)2.88417649
107protein complex localization (GO:0031503)2.85709360
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.84776272
109ribosome assembly (GO:0042255)2.81991401
110negative regulation of smooth muscle cell differentiation (GO:0051151)2.81622107
111regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.78465259
112mitotic nuclear envelope disassembly (GO:0007077)2.76348326
113spindle assembly involved in mitosis (GO:0090307)2.75555058
114cytoskeleton-dependent cytokinesis (GO:0061640)2.75360650
115chromatin assembly (GO:0031497)2.72557815
116regulation of coenzyme metabolic process (GO:0051196)2.69816661
117regulation of cofactor metabolic process (GO:0051193)2.69816661
118regulation of acyl-CoA biosynthetic process (GO:0050812)2.69657408
119nuclear envelope disassembly (GO:0051081)2.68804501
120membrane disassembly (GO:0030397)2.68804501
121glycolytic process (GO:0006096)2.68475623
122RNA localization (GO:0006403)2.66813673
123establishment of monopolar cell polarity (GO:0061162)2.66724009
124establishment or maintenance of monopolar cell polarity (GO:0061339)2.66724009
125bone remodeling (GO:0046849)2.65684536
126NLS-bearing protein import into nucleus (GO:0006607)2.64173760
127ether metabolic process (GO:0018904)2.63375174
128regulation of hippo signaling (GO:0035330)2.62893868
129regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62399688
130regulation of spindle organization (GO:0090224)2.61184860
131embryonic foregut morphogenesis (GO:0048617)2.60938267
132mitotic metaphase plate congression (GO:0007080)2.59574194
133microtubule-based movement (GO:0007018)2.58971757
134positive regulation of mitotic sister chromatid separation (GO:1901970)2.56666940
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.56666940
136regulation of sulfur metabolic process (GO:0042762)2.56472992
137cell migration involved in sprouting angiogenesis (GO:0002042)2.53508373
138cell fate commitment involved in formation of primary germ layer (GO:0060795)2.53293846
139mitotic chromosome condensation (GO:0007076)2.53242223
140morphogenesis of an epithelial sheet (GO:0002011)2.50999897
141regulation of transforming growth factor beta2 production (GO:0032909)2.49854082
142glomerular epithelial cell development (GO:0072310)2.48289401
143mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.47878168
144collagen fibril organization (GO:0030199)2.44039564
145positive regulation of developmental pigmentation (GO:0048087)2.43504476
146cardiac epithelial to mesenchymal transition (GO:0060317)2.40437371
147positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.39212333
148SMAD protein complex assembly (GO:0007183)2.39036220
149artery development (GO:0060840)2.38194472
150nucleobase-containing small molecule interconversion (GO:0015949)2.35329048
151wound healing, spreading of epidermal cells (GO:0035313)2.34366276
152vascular endothelial growth factor signaling pathway (GO:0038084)2.31726333
153kidney mesenchyme development (GO:0072074)2.30162579
154cellular response to vitamin D (GO:0071305)2.29411707
155establishment of viral latency (GO:0019043)2.28606486
156hypotonic response (GO:0006971)2.27611002
157positive regulation of cellular response to insulin stimulus (GO:1900078)2.26698299
158embryonic heart tube development (GO:0035050)2.26437299
159metaphase plate congression (GO:0051310)2.25730041
160plasma membrane repair (GO:0001778)2.25406470
161negative regulation of cartilage development (GO:0061037)2.24706434
162histone H2B ubiquitination (GO:0033523)2.24221592
163substrate adhesion-dependent cell spreading (GO:0034446)2.23891116
164regulation of Rac protein signal transduction (GO:0035020)2.23663276
165mammary gland epithelial cell proliferation (GO:0033598)2.22280018
166endothelium development (GO:0003158)2.22191767
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21476960
168positive regulation of Ras protein signal transduction (GO:0046579)2.21425019
169regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.20787546
170positive regulation of cell size (GO:0045793)2.19808349
171protein hydroxylation (GO:0018126)2.15156891
172protein localization to kinetochore (GO:0034501)2.14888733
173positive regulation of actin filament depolymerization (GO:0030836)2.14571870
174replicative senescence (GO:0090399)2.13364209
175regulation of sister chromatid cohesion (GO:0007063)2.11326822
176endodermal cell differentiation (GO:0035987)2.10571195
177ventricular cardiac muscle cell development (GO:0055015)2.10536315
178positive regulation of small GTPase mediated signal transduction (GO:0051057)2.10171163
179membrane assembly (GO:0071709)2.09865684
180regulation of glomerular filtration (GO:0003093)2.09680263
181mitotic sister chromatid segregation (GO:0000070)2.09061667
182positive regulation of Rho protein signal transduction (GO:0035025)2.07684034
183generation of neurons (GO:0048699)2.06778906
184lung epithelium development (GO:0060428)2.06642613
185DNA unwinding involved in DNA replication (GO:0006268)2.05486958
186sister chromatid segregation (GO:0000819)2.05236272
187metanephric mesenchyme development (GO:0072075)2.04928877
188negative regulation of protein tyrosine kinase activity (GO:0061099)2.03870411
189cellular protein complex localization (GO:0034629)2.01221259
190regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.01185976
191fusion of sperm to egg plasma membrane (GO:0007342)10.3516572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.89310552
2E2F7_22180533_ChIP-Seq_HELA_Human3.90365983
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87377608
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.15900582
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.96099855
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.73850247
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.73678321
8* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65698288
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60472065
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.50064418
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41784841
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.39661331
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38723815
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28362702
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26996205
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.21239431
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18923744
18* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13643734
19CTNNB1_20460455_ChIP-Seq_HCT116_Human2.10181387
20* BRD4_25478319_ChIP-Seq_HGPS_Human2.03559049
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.01832555
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.90245098
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89761170
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89325155
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89089988
26CLOCK_20551151_ChIP-Seq_293T_Human1.88610354
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.87813374
28CJUN_26792858_Chip-Seq_BT549_Human1.76293289
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74847797
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74722908
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73737686
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73310188
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72713112
34EZH2_22144423_ChIP-Seq_EOC_Human1.72555247
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71648512
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65206594
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63679202
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60236242
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60236242
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60236242
41* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59627804
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59097104
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56613399
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55143030
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54922425
46ZNF274_21170338_ChIP-Seq_K562_Hela1.54790691
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52690216
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51118770
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50922988
50* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49778490
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47851636
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47557018
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46634580
54TP53_16413492_ChIP-PET_HCT116_Human1.45335538
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44840863
56* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44830112
57* MYC_18555785_ChIP-Seq_MESCs_Mouse1.40223600
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39158178
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36512970
60* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.35757268
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.35367441
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34165655
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33682914
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33564134
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33564134
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32218170
67FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32183272
68ZNF263_19887448_ChIP-Seq_K562_Human1.27089809
69SOX17_20123909_ChIP-Seq_XEN_Mouse1.26765248
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25479063
71TP53_22127205_ChIP-Seq_IMR90_Human1.24430156
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23749640
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22290791
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21515072
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21515072
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21502552
77VDR_22108803_ChIP-Seq_LS180_Human1.21385136
78* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20530985
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20478529
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20260418
81NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19910737
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19883103
83FUS_26573619_Chip-Seq_HEK293_Human1.18634456
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18351513
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18270014
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.17806429
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.17417168
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17003782
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16227834
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15993373
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15530768
92AR_21909140_ChIP-Seq_LNCAP_Human1.15022024
93* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14038203
94* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13839148
95TP53_18474530_ChIP-ChIP_U2OS_Human1.13556636
96* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12610494
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.12457082
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10833057
99* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09925638
100NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09431990
101* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09195355
102* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08901355
103ATF3_27146783_Chip-Seq_COLON_Human1.07920945
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06294990
105STAT3_18555785_ChIP-Seq_MESCs_Mouse1.05609785
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05267609
107* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04009714
108* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02331557
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01390645
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00326193
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99510671
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99230060
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98963193
114* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98808974
115* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98644306
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97286260
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95913451
118NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95399934
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.95020524
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94921901
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94820576
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94759850
123ELK1_19687146_ChIP-ChIP_HELA_Human0.94671125
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93995531
125* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93925183
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93863753
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93580883
128RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93572720
129AHR_22903824_ChIP-Seq_MCF-7_Human0.92907570
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.92889177
131* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92415961
132* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92255285
133E2F1_21310950_ChIP-Seq_MCF-7_Human0.92212734
134POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92055832
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91313796
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90981296
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90580171
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.90158066
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.88996591
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88528674
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88391441
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.88382221
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88286946
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87612798
145* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87210573
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86697382
147CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86383209
148FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85395873
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84846936
150STAT1_17558387_ChIP-Seq_HELA_Human0.84087525
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82850932
152SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82639559
153* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82409744
154MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82350230
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.81378786
156STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81043714
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80729143
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78619689
159* NANOG_16518401_ChIP-PET_MESCs_Mouse0.77091874
160TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76601158
161RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76180942
162PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75486022
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75251705
164* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74826496
165KAP1_27257070_Chip-Seq_ESCs_Mouse0.74682769
166* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.74023979
167* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.73065137
168IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72618943
169CBP_20019798_ChIP-Seq_JUKART_Human0.72618943
170SOX9_26525672_Chip-Seq_HEART_Mouse0.72376715
171RUNX1_27514584_Chip-Seq_MCF-7_Human0.72122626
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71953756
173CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71681887
174YY1_22570637_ChIP-Seq_MALME-3M_Human0.71141015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive3.98023239
2MP0005623_abnormal_meninges_morphology3.91119933
3MP0001929_abnormal_gametogenesis3.70941782
4MP0008877_abnormal_DNA_methylation3.53732744
5MP0002653_abnormal_ependyma_morphology3.15274198
6MP0010368_abnormal_lymphatic_system2.98764158
7MP0002210_abnormal_sex_determination2.62402606
8MP0004185_abnormal_adipocyte_glucose2.55910932
9MP0002877_abnormal_melanocyte_morpholog2.51201347
10MP0005257_abnormal_intraocular_pressure2.47757467
11MP0001879_abnormal_lymphatic_vessel2.35198680
12MP0002161_abnormal_fertility/fecundity2.27570703
13MP0001145_abnormal_male_reproductive2.26215142
14MP0009697_abnormal_copulation2.16243731
15MP0005410_abnormal_fertilization10.2091785
16MP0010352_gastrointestinal_tract_polyps1.98198954
17MP0003705_abnormal_hypodermis_morpholog1.91172354
18MP0000653_abnormal_sex_gland1.90742784
19MP0004272_abnormal_basement_membrane1.89685332
20MP0008438_abnormal_cutaneous_collagen1.87625325
21MP0001299_abnormal_eye_distance/1.84995622
22MP0005670_abnormal_white_adipose1.84045631
23MP0009780_abnormal_chondrocyte_physiolo1.79516110
24MP0010094_abnormal_chromosome_stability1.77689083
25MP0003111_abnormal_nucleus_morphology1.77686076
26MP0002282_abnormal_trachea_morphology1.70219877
27MP0002160_abnormal_reproductive_system1.65991434
28MP0004233_abnormal_muscle_weight1.55120014
29MP0004957_abnormal_blastocyst_morpholog1.54242501
30MP0003115_abnormal_respiratory_system1.53073356
31MP0001730_embryonic_growth_arrest1.52690319
32MP0000537_abnormal_urethra_morphology1.51821231
33MP0002084_abnormal_developmental_patter1.46527173
34MP0005275_abnormal_skin_tensile1.44670083
35MP0000762_abnormal_tongue_morphology1.44656847
36MP0005377_hearing/vestibular/ear_phenot1.44334343
37MP0003878_abnormal_ear_physiology1.44334343
38MP0003566_abnormal_cell_adhesion1.42815992
39MP0003077_abnormal_cell_cycle1.40122794
40MP0005076_abnormal_cell_differentiation1.31983914
41MP0004133_heterotaxia1.31853744
42MP0008007_abnormal_cellular_replicative1.31623696
43MP0004197_abnormal_fetal_growth/weight/1.30994887
44MP0005380_embryogenesis_phenotype1.30679449
45MP0001672_abnormal_embryogenesis/_devel1.30679449
46MP0003279_aneurysm1.25289808
47MP0003283_abnormal_digestive_organ1.24992509
48MP0002085_abnormal_embryonic_tissue1.24613042
49MP0005187_abnormal_penis_morphology1.24418066
50MP0008057_abnormal_DNA_replication1.23568945
51MP0000534_abnormal_ureter_morphology1.22694151
52MP0000767_abnormal_smooth_muscle1.22371444
53MP0005503_abnormal_tendon_morphology1.22110055
54MP0010307_abnormal_tumor_latency1.21543863
55MP0001697_abnormal_embryo_size1.19500695
56MP0002233_abnormal_nose_morphology1.18465424
57MP0003984_embryonic_growth_retardation1.18361758
58MP0001849_ear_inflammation1.17152863
59MP0002088_abnormal_embryonic_growth/wei1.15656242
60MP0003693_abnormal_embryo_hatching1.14622976
61MP0003123_paternal_imprinting1.13565619
62MP0008961_abnormal_basal_metabolism1.11811413
63MP0000350_abnormal_cell_proliferation1.11798563
64MP0002086_abnormal_extraembryonic_tissu1.10470993
65MP0005409_darkened_coat_color1.10054578
66MP0008932_abnormal_embryonic_tissue1.07879764
67MP0008058_abnormal_DNA_repair1.07475665
68MP0001293_anophthalmia1.05838337
69MP0003941_abnormal_skin_development1.05621926
70MP0003942_abnormal_urinary_system1.04637390
71MP0006054_spinal_hemorrhage1.03080909
72MP0003755_abnormal_palate_morphology1.02859894
73MP0003091_abnormal_cell_migration1.02679695
74MP0001286_abnormal_eye_development1.01571020
75MP0009278_abnormal_bone_marrow1.00492497
76MP0000733_abnormal_muscle_development0.99286643
77MP0009053_abnormal_anal_canal0.98704776
78MP0010678_abnormal_skin_adnexa0.97902245
79MP0004084_abnormal_cardiac_muscle0.97081020
80MP0005375_adipose_tissue_phenotype0.96924843
81MP0002060_abnormal_skin_morphology0.96499159
82MP0003119_abnormal_digestive_system0.96335970
83MP0002080_prenatal_lethality0.95954701
84MP0005023_abnormal_wound_healing0.94141895
85MP0000569_abnormal_digit_pigmentation0.93853499
86MP0002177_abnormal_outer_ear0.93515206
87MP0001915_intracranial_hemorrhage0.90052817
88MP0001348_abnormal_lacrimal_gland0.89508662
89MP0009250_abnormal_appendicular_skeleto0.88861152
90MP0002925_abnormal_cardiovascular_devel0.87216125
91MP0005389_reproductive_system_phenotype0.87183128
92MP0003011_delayed_dark_adaptation0.86811450
93MP0003786_premature_aging0.85345027
94MP0003950_abnormal_plasma_membrane0.84941710
95MP0003385_abnormal_body_wall0.82996457
96MP0003121_genomic_imprinting0.81282118
97MP0005197_abnormal_uvea_morphology0.81121931
98MP0003861_abnormal_nervous_system0.80655608
99MP0002092_abnormal_eye_morphology0.79649785
100MP0002697_abnormal_eye_size0.78401970
101MP0010234_abnormal_vibrissa_follicle0.77816676
102MP0005193_abnormal_anterior_eye0.77689594
103MP0002234_abnormal_pharynx_morphology0.77314979
104MP0000432_abnormal_head_morphology0.77259530
105MP0008995_early_reproductive_senescence0.76555083
106MP0000013_abnormal_adipose_tissue0.75953095
107MP0005248_abnormal_Harderian_gland0.75316857
108MP0005508_abnormal_skeleton_morphology0.74397117
109MP0002896_abnormal_bone_mineralization0.73369265
110MP0001340_abnormal_eyelid_morphology0.73263549
111MP0000358_abnormal_cell_content/0.73182609
112MP0003935_abnormal_craniofacial_develop0.71777350
113MP0005391_vision/eye_phenotype0.71302244
114MP0002269_muscular_atrophy0.70050365
115MP0005171_absent_coat_pigmentation0.69518938
116MP0010630_abnormal_cardiac_muscle0.69108109
117MP0009703_decreased_birth_body0.69061912
118MP0002938_white_spotting0.68463134
119MP0000049_abnormal_middle_ear0.68413839
120MP0001661_extended_life_span0.68215594
121MP0002108_abnormal_muscle_morphology0.67930504
122MP0003937_abnormal_limbs/digits/tail_de0.67451159
123MP0003045_fibrosis0.67030928
124MP0005666_abnormal_adipose_tissue0.65290284
125MP0006138_congestive_heart_failure0.64851943
126MP0003890_abnormal_embryonic-extraembry0.64719402
127MP0000266_abnormal_heart_morphology0.64090532
128MP0004808_abnormal_hematopoietic_stem0.60790178
129MP0001958_emphysema0.60171329
130MP0000516_abnormal_urinary_system0.59458584
131MP0005367_renal/urinary_system_phenotyp0.59458584
132MP0010030_abnormal_orbit_morphology0.59308977
133MP0003936_abnormal_reproductive_system0.58791930
134MP0000428_abnormal_craniofacial_morphol0.56620403
135MP0001784_abnormal_fluid_regulation0.56599788
136MP0001614_abnormal_blood_vessel0.55896839

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.50070000
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.50070000
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.30407622
4Abnormal respiratory epithelium morphology (HP:0012253)6.21572974
5Abnormal respiratory motile cilium morphology (HP:0005938)6.21572974
6Abnormal respiratory motile cilium physiology (HP:0012261)6.18379998
7Rhinitis (HP:0012384)5.14666220
8Infertility (HP:0000789)5.03257145
9Chronic bronchitis (HP:0004469)4.79005924
10Abnormal ciliary motility (HP:0012262)4.72485232
11Male infertility (HP:0003251)4.36494552
12Nasal polyposis (HP:0100582)4.33701462
13Abnormality of the nasal mucosa (HP:0000433)3.67859979
14Nephronophthisis (HP:0000090)3.42681311
15Impulsivity (HP:0100710)3.33942267
16Bronchitis (HP:0012387)3.27662366
17Insomnia (HP:0100785)3.25934632
18Arterial tortuosity (HP:0005116)3.24698467
19Vascular tortuosity (HP:0004948)3.21905129
20Soft skin (HP:0000977)3.18191661
21Aortic dissection (HP:0002647)3.03377996
22Vertebral arch anomaly (HP:0008438)2.96326807
23Abnormality of the lower motor neuron (HP:0002366)2.95562314
24Bronchiectasis (HP:0002110)2.82548635
25Heterotopia (HP:0002282)2.73758913
26Elfin facies (HP:0004428)2.71184551
27Abnormal spermatogenesis (HP:0008669)2.70921490
28Aortic aneurysm (HP:0004942)2.60564601
29Abnormality of the renal medulla (HP:0100957)2.59252003
30Tubular atrophy (HP:0000092)2.56652552
31Abnormality of dentin (HP:0010299)2.56043839
32Termporal pattern (HP:0011008)2.55141003
33Insidious onset (HP:0003587)2.55141003
34Protrusio acetabuli (HP:0003179)2.51591029
35Short humerus (HP:0005792)2.50753552
36Recurrent otitis media (HP:0000403)2.41110386
37Coronal craniosynostosis (HP:0004440)2.38189303
38Skull defect (HP:0001362)2.32665555
39Aplasia/hypoplasia of the humerus (HP:0006507)2.30402361
40Recurrent bronchitis (HP:0002837)2.26766660
41Selective tooth agenesis (HP:0001592)2.24593021
42Short ribs (HP:0000773)2.24196011
43Supernumerary spleens (HP:0009799)2.24189463
44Gonadotropin excess (HP:0000837)2.24130415
45Mitral valve prolapse (HP:0001634)2.22027258
46Broad metatarsal (HP:0001783)2.20232644
47Pulmonic stenosis (HP:0001642)2.15163667
48Subacute progressive viral hepatitis (HP:0006572)2.14020134
49Spinal rigidity (HP:0003306)2.12612052
50Cerebral aneurysm (HP:0004944)2.10039244
51Tubulointerstitial nephritis (HP:0001970)2.09818064
52Syringomyelia (HP:0003396)2.08447395
53Spinal cord lesions (HP:0100561)2.08447395
54Overgrowth (HP:0001548)2.07465747
55Atrophic scars (HP:0001075)2.07457009
56Protruding ear (HP:0000411)2.05885158
57Increased nuchal translucency (HP:0010880)2.03968259
58Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03816990
59Missing ribs (HP:0000921)2.03697586
60Absent frontal sinuses (HP:0002688)2.03072337
61Neonatal short-limb short stature (HP:0008921)2.03060517
62Ependymoma (HP:0002888)2.02265368
63Short 4th metacarpal (HP:0010044)2.01441937
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01441937
65Papillary thyroid carcinoma (HP:0002895)1.99479787
66Follicular hyperkeratosis (HP:0007502)1.98462312
67Arnold-Chiari malformation (HP:0002308)1.97571935
68Ankle contracture (HP:0006466)1.96603959
69Bell-shaped thorax (HP:0001591)1.95924785
70Hand muscle atrophy (HP:0009130)1.95253894
71Hyporeflexia of lower limbs (HP:0002600)1.95012784
72Wormian bones (HP:0002645)1.92288397
73Ankyloglossia (HP:0010296)1.90055163
74Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87125585
75Fragile skin (HP:0001030)1.85992793
76Short nail (HP:0001799)1.84459856
77Difficulty climbing stairs (HP:0003551)1.84121658
78Hyperextensible skin (HP:0000974)1.83945454
79Stage 5 chronic kidney disease (HP:0003774)1.82393909
80Broad distal phalanx of finger (HP:0009836)1.80807503
81Abnormality of the astrocytes (HP:0100707)1.79802050
82Astrocytoma (HP:0009592)1.79802050
83Amyotrophic lateral sclerosis (HP:0007354)1.79572848
84Tubulointerstitial abnormality (HP:0001969)1.77151013
85Abnormality of abdominal situs (HP:0011620)1.77128801
86Abdominal situs inversus (HP:0003363)1.77128801
87Glossoptosis (HP:0000162)1.74138871
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73649102
89Choroideremia (HP:0001139)1.72043797
90Limited hip movement (HP:0008800)1.71780256
91Abnormality of the intrinsic pathway (HP:0010989)1.71580695
92Aortic valve stenosis (HP:0001650)1.70955092
93Distal upper limb amyotrophy (HP:0007149)1.70137942
94Upper limb amyotrophy (HP:0009129)1.70137942
95Diaphragmatic weakness (HP:0009113)1.69771412
96Abnormality of the anterior horn cell (HP:0006802)1.68242891
97Degeneration of anterior horn cells (HP:0002398)1.68242891
98High pitched voice (HP:0001620)1.67475650
99Rhizomelia (HP:0008905)1.67161360
100Shallow orbits (HP:0000586)1.67058103
101Recurrent sinusitis (HP:0011108)1.66074175
102Turricephaly (HP:0000262)1.65926558
103Molar tooth sign on MRI (HP:0002419)1.64793561
104Abnormality of midbrain morphology (HP:0002418)1.64793561
105Neoplasm of the oral cavity (HP:0100649)1.64218455
106Fibular hypoplasia (HP:0003038)1.64137588
107Truncal obesity (HP:0001956)1.63631318
108Hyperacusis (HP:0010780)1.61510153
109Absent eyebrow (HP:0002223)1.60813123
110Abnormality of oral frenula (HP:0000190)1.60662598
111Short chin (HP:0000331)1.60047034
112Stenosis of the external auditory canal (HP:0000402)1.59919228
113Wide anterior fontanel (HP:0000260)1.59587804
114Genu recurvatum (HP:0002816)1.59547056
115Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.57616338
116Azoospermia (HP:0000027)1.57025094
117Wrist flexion contracture (HP:0001239)1.56675713
11811 pairs of ribs (HP:0000878)1.56574996
119Premature rupture of membranes (HP:0001788)1.55790454
120Bronchomalacia (HP:0002780)1.55464731
121Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.55409024
122Hypoplasia of the iris (HP:0007676)1.55058214
123Hypopigmentation of the fundus (HP:0007894)1.54916154
124Aplasia involving bones of the upper limbs (HP:0009823)1.54156318
125Aplasia of the phalanges of the hand (HP:0009802)1.54156318
126Aplasia involving bones of the extremities (HP:0009825)1.54156318
127Bowel diverticulosis (HP:0005222)1.53431594
128Ulnar bowing (HP:0003031)1.52186973
129Microglossia (HP:0000171)1.51975083
130Chromsome breakage (HP:0040012)1.51740842
131Thin skin (HP:0000963)1.51638986
132Overriding aorta (HP:0002623)1.51636524
133Joint laxity (HP:0001388)1.51344177
134Capillary hemangiomas (HP:0005306)1.50347503
135Knee flexion contracture (HP:0006380)1.49658961
136Neoplasm of the peripheral nervous system (HP:0100007)1.49554121
137EMG: neuropathic changes (HP:0003445)1.49550545
138Blue sclerae (HP:0000592)1.49196531
139Decreased motor nerve conduction velocity (HP:0003431)1.48685324
140Facial cleft (HP:0002006)1.47779146
141Renovascular hypertension (HP:0100817)1.47111445
142Increased connective tissue (HP:0009025)1.46753280
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.46733358
144Osteolytic defects of the hand bones (HP:0009699)1.46733358
145Bladder diverticulum (HP:0000015)1.46446120
146Deviation of the thumb (HP:0009603)1.45169336
147Gastrointestinal carcinoma (HP:0002672)1.45041649
148Malignant gastrointestinal tract tumors (HP:0006749)1.45041649
149Asymmetry of the thorax (HP:0001555)1.44834669
150Midface retrusion (HP:0011800)1.43321711
151Nephroblastoma (Wilms tumor) (HP:0002667)1.43320005
152Abnormality of the 4th metacarpal (HP:0010012)1.43316962
153Supernumerary ribs (HP:0005815)1.42191138
154Cubitus valgus (HP:0002967)1.41852443
155Embryonal renal neoplasm (HP:0011794)1.41774226
156Hammertoe (HP:0001765)1.41715282
157Transitional cell carcinoma of the bladder (HP:0006740)1.41696471
158Abnormality of the epiphyses of the hand (HP:0005924)1.41438093
159Abnormal auditory evoked potentials (HP:0006958)1.40963139
160Flat cornea (HP:0007720)1.40374584
161Mitral regurgitation (HP:0001653)1.40258178
162Cutaneous finger syndactyly (HP:0010554)1.39901716
163Vertebral clefting (HP:0008428)1.39735248
164Cortical dysplasia (HP:0002539)1.39725933
165Medulloblastoma (HP:0002885)1.39688760
166Hip contracture (HP:0003273)1.39042657
167Difficulty running (HP:0009046)1.39037825
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38255047
169Absent epiphyses (HP:0010577)1.38255047
170Hemiparesis (HP:0001269)1.38067884
171Hemorrhage of the eye (HP:0011885)1.37755111
172Short thorax (HP:0010306)1.37178667
173Tubulointerstitial fibrosis (HP:0005576)1.35774481
174Cervical subluxation (HP:0003308)1.35764497
175Ectopia lentis (HP:0001083)1.35678999
176Uterine leiomyosarcoma (HP:0002891)1.35295439
177Leiomyosarcoma (HP:0100243)1.35295439
178Renal cell carcinoma (HP:0005584)1.33756165
179Ectopic kidney (HP:0000086)1.33472373
180Renal duplication (HP:0000075)1.32989359
181Aplasia/Hypoplasia of the fibula (HP:0006492)1.32950906
182Ulnar claw (HP:0001178)1.32574823
183Relative macrocephaly (HP:0004482)1.32395012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.02872998
2PDK46.02872998
3TESK15.21721940
4PRKD34.72291280
5MST1R4.17226410
6MST44.01854580
7PDK23.98453683
8ICK3.94350107
9PNCK2.99367723
10TNIK2.69401679
11CDK122.41625530
12PBK2.30683575
13NEK22.23727182
14PTK2B2.06106463
15TIE12.04047456
16EPHA22.00099076
17EEF2K1.59335052
18CDC71.58178103
19STK381.54753204
20LATS21.40306009
21TTK1.39681175
22EIF2AK31.37113746
23WEE11.35742337
24TAF11.33824297
25DYRK1B1.32122280
26WNK41.31634848
27ERBB31.31184162
28TTN1.29863835
29MAP3K101.29664872
30TYRO31.27921382
31EIF2AK11.18757997
32LATS11.14768147
33MTOR1.12919228
34WNK11.11500795
35STK31.07605676
36PAK21.02921170
37MKNK21.02244507
38PAK40.98561662
39STK390.98209073
40CHEK20.97789433
41NEK10.95300611
42PASK0.94825729
43BCR0.93784782
44CAMK1G0.92237313
45RPS6KB20.91653765
46CHEK10.91344265
47STK38L0.90676179
48STK100.89929462
49MAP3K90.87336743
50MKNK10.84020587
51DDR20.83117036
52MAP3K120.82530265
53PLK20.81836334
54PDGFRA0.80853083
55STK240.77522556
56PLK10.75328179
57MAPKAPK30.75145960
58TESK20.74392448
59PKN20.73494546
60EIF2AK20.73434420
61BRSK10.73410174
62DYRK30.72330773
63ROCK20.71044405
64LMTK20.70031906
65CDK80.68706571
66RIPK10.68697768
67ATM0.67653783
68MARK10.65841128
69TRIB30.65482088
70PAK10.64508843
71ATR0.64342031
72PTK20.64307900
73CDK60.63922993
74AKT20.62313713
75MELK0.61180061
76MET0.59958110
77CDK40.58376856
78KDR0.56100397
79BRD40.55412799
80BRAF0.55207459
81MAP3K80.55128986
82CDK70.53206293
83MYLK0.51057266
84FER0.50573863
85KSR10.49562671
86SCYL20.48844644
87BUB10.48223514
88SRPK10.46206107
89TRIM280.45768991
90CDK20.45464712
91PLK30.45303018
92AURKB0.44230803
93PDK10.42373548
94BMPR1B0.41372653
95AURKA0.40884664
96BMX0.40818779
97PRKCE0.39617779
98CSNK1A1L0.38670470
99ABL20.37743615
100TGFBR10.37101329
101NEK60.36759462
102EGFR0.35469454
103ALK0.35075466
104CDK180.34866582
105CCNB10.34855784
106CDK10.34484269
107PTK60.34445272
108NEK90.33617833
109ILK0.32455350
110TRPM70.32098359
111NTRK10.31941708
112CSNK1E0.31707234
113LRRK20.31512043
114LIMK10.30976199
115TGFBR20.30754524
116BRSK20.29194103
117EPHB20.29153371
118PAK60.28381025
119FGFR10.27282062
120PIM10.26757617
121GSK3B0.25806658
122AKT30.25798865
123MARK30.25132647
124PRKDC0.24024930
125PAK30.23504836
126PDGFRB0.23071631
127INSR0.19991957
128RET0.19288792
129* MAPK10.18603571
130PRKAA10.18570360
131DMPK0.17764053
132* CSNK1D0.17740766
133TSSK60.17605585
134CDK90.16607458
135RPS6KB10.16559006
136CDK140.16028933
137CAMK1D0.15961267
138ROCK10.15866442
139PLK40.15607101
140ERBB40.15517292
141MAPK140.14511595

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.85228741
2RNA transport_Homo sapiens_hsa030132.75444947
3Fatty acid biosynthesis_Homo sapiens_hsa000612.59833625
4mRNA surveillance pathway_Homo sapiens_hsa030152.28986883
5Dorso-ventral axis formation_Homo sapiens_hsa043202.26470327
6Oocyte meiosis_Homo sapiens_hsa041142.15544324
7Cell cycle_Homo sapiens_hsa041101.83855335
8Hedgehog signaling pathway_Homo sapiens_hsa043401.82489496
9Adherens junction_Homo sapiens_hsa045201.82075793
10Glucagon signaling pathway_Homo sapiens_hsa049221.81830410
11Fanconi anemia pathway_Homo sapiens_hsa034601.81769030
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.78271534
13Basal transcription factors_Homo sapiens_hsa030221.74741318
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.72646413
15Pyruvate metabolism_Homo sapiens_hsa006201.66425169
16Basal cell carcinoma_Homo sapiens_hsa052171.63702816
17Hippo signaling pathway_Homo sapiens_hsa043901.61294789
18ECM-receptor interaction_Homo sapiens_hsa045121.59517855
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58729736
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.51979001
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48310312
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45638801
23DNA replication_Homo sapiens_hsa030301.44942050
24Melanogenesis_Homo sapiens_hsa049161.44421063
25Selenocompound metabolism_Homo sapiens_hsa004501.44166328
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44056276
27Mismatch repair_Homo sapiens_hsa034301.37671911
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36791772
29Tight junction_Homo sapiens_hsa045301.35067647
30Focal adhesion_Homo sapiens_hsa045101.34325236
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32475265
32Small cell lung cancer_Homo sapiens_hsa052221.26805260
33p53 signaling pathway_Homo sapiens_hsa041151.26669897
34Axon guidance_Homo sapiens_hsa043601.26529677
35Spliceosome_Homo sapiens_hsa030401.25179229
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19732304
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15241500
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14778551
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11074214
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10252290
41Viral carcinogenesis_Homo sapiens_hsa052031.10032436
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09337019
43MicroRNAs in cancer_Homo sapiens_hsa052061.08621845
44Estrogen signaling pathway_Homo sapiens_hsa049151.06764982
45TGF-beta signaling pathway_Homo sapiens_hsa043501.06708462
46Protein digestion and absorption_Homo sapiens_hsa049741.06514327
47ErbB signaling pathway_Homo sapiens_hsa040121.06340023
48Vitamin B6 metabolism_Homo sapiens_hsa007501.05701497
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05097651
50Antigen processing and presentation_Homo sapiens_hsa046121.02606175
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00663075
52Dilated cardiomyopathy_Homo sapiens_hsa054141.00194335
53Proteoglycans in cancer_Homo sapiens_hsa052050.99569908
54Systemic lupus erythematosus_Homo sapiens_hsa053220.98523564
55Nucleotide excision repair_Homo sapiens_hsa034200.95246385
56Fructose and mannose metabolism_Homo sapiens_hsa000510.93806132
57Wnt signaling pathway_Homo sapiens_hsa043100.93540539
58Gap junction_Homo sapiens_hsa045400.92269786
59Linoleic acid metabolism_Homo sapiens_hsa005910.92032779
60RNA degradation_Homo sapiens_hsa030180.91254388
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90897875
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89318572
63mTOR signaling pathway_Homo sapiens_hsa041500.84771611
64HIF-1 signaling pathway_Homo sapiens_hsa040660.84123624
65Glycerolipid metabolism_Homo sapiens_hsa005610.83262373
66Long-term potentiation_Homo sapiens_hsa047200.81297625
67Thyroid cancer_Homo sapiens_hsa052160.80837995
68Renal cell carcinoma_Homo sapiens_hsa052110.78542100
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78448116
70Bladder cancer_Homo sapiens_hsa052190.78291641
71Biosynthesis of amino acids_Homo sapiens_hsa012300.78099693
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77251414
73Steroid biosynthesis_Homo sapiens_hsa001000.77032196
74Pentose phosphate pathway_Homo sapiens_hsa000300.76764119
75Base excision repair_Homo sapiens_hsa034100.76381269
76Carbon metabolism_Homo sapiens_hsa012000.75180885
77HTLV-I infection_Homo sapiens_hsa051660.75177069
78Olfactory transduction_Homo sapiens_hsa047400.74231646
79Circadian rhythm_Homo sapiens_hsa047100.73861771
80Pancreatic cancer_Homo sapiens_hsa052120.72728774
81AMPK signaling pathway_Homo sapiens_hsa041520.72126868
82Ras signaling pathway_Homo sapiens_hsa040140.70265932
83Prostate cancer_Homo sapiens_hsa052150.70211655
84Pathways in cancer_Homo sapiens_hsa052000.69053634
85Non-homologous end-joining_Homo sapiens_hsa034500.69023107
86Glutamatergic synapse_Homo sapiens_hsa047240.67743635
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66981580
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66730804
89Mineral absorption_Homo sapiens_hsa049780.66382427
90Amoebiasis_Homo sapiens_hsa051460.65533284
91VEGF signaling pathway_Homo sapiens_hsa043700.65137459
92Cocaine addiction_Homo sapiens_hsa050300.65018942
93Homologous recombination_Homo sapiens_hsa034400.64710246
94Endocytosis_Homo sapiens_hsa041440.64423490
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.64130373
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62676007
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.62112290
98Dopaminergic synapse_Homo sapiens_hsa047280.61764622
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61082901
100Epstein-Barr virus infection_Homo sapiens_hsa051690.60582187
101Colorectal cancer_Homo sapiens_hsa052100.60495749
102Prion diseases_Homo sapiens_hsa050200.60414559
103Endometrial cancer_Homo sapiens_hsa052130.59930006
104One carbon pool by folate_Homo sapiens_hsa006700.59707369
105PPAR signaling pathway_Homo sapiens_hsa033200.59315811
106Viral myocarditis_Homo sapiens_hsa054160.58255799
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.57259591
108Alcoholism_Homo sapiens_hsa050340.57025458
109Purine metabolism_Homo sapiens_hsa002300.56408586
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54778261
111Propanoate metabolism_Homo sapiens_hsa006400.54688318
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51192565
113Melanoma_Homo sapiens_hsa052180.50885884
114Renin-angiotensin system_Homo sapiens_hsa046140.50388909
115Thyroid hormone synthesis_Homo sapiens_hsa049180.49159760
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48972306
117Notch signaling pathway_Homo sapiens_hsa043300.47727979
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47611455
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47565492
120Arginine and proline metabolism_Homo sapiens_hsa003300.46290933
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46181813
122Insulin signaling pathway_Homo sapiens_hsa049100.45123319
123Lysine degradation_Homo sapiens_hsa003100.44820181
124Glioma_Homo sapiens_hsa052140.44214898
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44162484
126Rap1 signaling pathway_Homo sapiens_hsa040150.44061617
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.43951972
128Amphetamine addiction_Homo sapiens_hsa050310.43163396
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42787711
130Shigellosis_Homo sapiens_hsa051310.41876842
131Nicotine addiction_Homo sapiens_hsa050330.41780506
132Long-term depression_Homo sapiens_hsa047300.41293368
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41115281

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