AKAP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.65380490
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.35200927
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.35200927
4antigen processing and presentation of endogenous antigen (GO:0019883)5.15178869
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65474242
6regulation of gamma-delta T cell differentiation (GO:0045586)4.32597628
7negative T cell selection (GO:0043383)4.31996709
8definitive hemopoiesis (GO:0060216)4.28080274
9negative thymic T cell selection (GO:0045060)4.25381678
10regulation of gamma-delta T cell activation (GO:0046643)4.22455013
11interferon-gamma production (GO:0032609)4.15936980
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06081364
13macrophage activation involved in immune response (GO:0002281)3.93832244
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.89822209
15regulation of B cell receptor signaling pathway (GO:0050855)3.84186623
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83333920
17positive thymic T cell selection (GO:0045059)3.78289718
18detection of molecule of bacterial origin (GO:0032490)3.77830758
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.75921370
20negative regulation of cell killing (GO:0031342)3.75921370
21positive regulation of B cell differentiation (GO:0045579)3.67215476
22megakaryocyte development (GO:0035855)3.65053285
23regulation of B cell differentiation (GO:0045577)3.64223427
24detection of other organism (GO:0098543)3.62090523
25microglial cell activation (GO:0001774)3.51679896
26thymic T cell selection (GO:0045061)3.49643389
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.47231453
28T cell selection (GO:0045058)3.46468635
29detection of external biotic stimulus (GO:0098581)3.38507450
30leukocyte aggregation (GO:0070486)3.38057764
31negative regulation of phagocytosis (GO:0050765)3.37254739
32regulation of alpha-beta T cell proliferation (GO:0046640)3.34412895
33response to interleukin-15 (GO:0070672)3.34368589
34histone H3-K36 demethylation (GO:0070544)3.32069417
35negative regulation of T cell mediated immunity (GO:0002710)3.30838368
36positive T cell selection (GO:0043368)3.30618170
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.29730078
38detection of bacterium (GO:0016045)3.29601006
39positive regulation of granulocyte differentiation (GO:0030854)3.25002174
40positive regulation of interleukin-2 production (GO:0032743)3.23877861
41response to muramyl dipeptide (GO:0032495)3.23085071
42T cell migration (GO:0072678)3.18773470
43myeloid dendritic cell activation (GO:0001773)3.18304114
44macrophage activation (GO:0042116)3.18264539
45activated T cell proliferation (GO:0050798)3.17960985
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16992117
47cellular response to ethanol (GO:0071361)3.14353346
48positive regulation of isotype switching (GO:0045830)3.14007783
49response to type I interferon (GO:0034340)3.13389944
50positive regulation of natural killer cell differentiation (GO:0032825)3.08995159
51cellular response to interleukin-15 (GO:0071350)3.08275526
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.07561709
53NIK/NF-kappaB signaling (GO:0038061)3.06944355
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04868637
55B cell receptor signaling pathway (GO:0050853)3.04364694
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03965173
57cellular response to type I interferon (GO:0071357)3.03004480
58type I interferon signaling pathway (GO:0060337)3.03004480
59detection of biotic stimulus (GO:0009595)3.01517588
60regulation of interleukin-2 biosynthetic process (GO:0045076)3.01449556
61regulation of T cell tolerance induction (GO:0002664)3.00004697
62regulation of T cell receptor signaling pathway (GO:0050856)2.97777402
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95908779
64response to host immune response (GO:0052572)2.95908779
65antigen processing and presentation via MHC class Ib (GO:0002475)2.93450917
66regulation of necroptotic process (GO:0060544)2.92585479
67response to host (GO:0075136)2.92258955
68response to host defenses (GO:0052200)2.92258955
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.92258955
70neutrophil mediated immunity (GO:0002446)2.91656094
71histone H3-K4 trimethylation (GO:0080182)2.89863363
72interferon-gamma-mediated signaling pathway (GO:0060333)2.89061814
73regulation of isotype switching to IgG isotypes (GO:0048302)2.88163821
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.87746950
75negative regulation of leukocyte mediated immunity (GO:0002704)2.86875225
76positive regulation of interferon-alpha production (GO:0032727)2.86558351
77tolerance induction (GO:0002507)2.86253767
78neutrophil activation (GO:0042119)2.81554058
79myeloid cell activation involved in immune response (GO:0002275)2.81416603
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.79834095
81negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.79414488
82regulation of interferon-alpha production (GO:0032647)2.78723251
83angiogenesis involved in wound healing (GO:0060055)2.77808139
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77339540
85response to protozoan (GO:0001562)2.77011206
86hepatocyte apoptotic process (GO:0097284)2.75291510
87regulation of response to interferon-gamma (GO:0060330)2.74107300
88germinal center formation (GO:0002467)2.73476465
89positive regulation of DNA recombination (GO:0045911)2.73007947
90natural killer cell activation (GO:0030101)2.73004820
91lymph node development (GO:0048535)2.72627626
92cellular extravasation (GO:0045123)2.72303309
93cellular response to zinc ion (GO:0071294)2.71841564
94negative regulation of B cell proliferation (GO:0030889)2.71591271
95defense response to protozoan (GO:0042832)2.70712115
96myeloid leukocyte mediated immunity (GO:0002444)2.69764131
97neutrophil activation involved in immune response (GO:0002283)2.69666519
98negative regulation of T-helper cell differentiation (GO:0045623)2.69413520
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69413520
100mast cell activation (GO:0045576)2.68971212
101T cell homeostasis (GO:0043029)2.68777036
102myeloid dendritic cell differentiation (GO:0043011)2.68655544
103immunoglobulin mediated immune response (GO:0016064)2.68137581
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.67956021
105positive regulation of tolerance induction (GO:0002645)2.66651433
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.66212151
107response to peptidoglycan (GO:0032494)2.66170209
108embryonic hemopoiesis (GO:0035162)2.64013374
109positive regulation of antigen processing and presentation (GO:0002579)2.63321165
110regulation of tolerance induction (GO:0002643)2.63018815
111production of molecular mediator involved in inflammatory response (GO:0002532)2.62279320
112leukocyte cell-cell adhesion (GO:0007159)2.62207791
113alpha-beta T cell activation (GO:0046631)2.61865187
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61566561
115CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61466395
116T-helper cell differentiation (GO:0042093)2.61466395
117antigen receptor-mediated signaling pathway (GO:0050851)2.61108958
118regulation of interferon-beta biosynthetic process (GO:0045357)2.60665120
119positive regulation of immunoglobulin mediated immune response (GO:0002891)2.60658233
120positive regulation of B cell mediated immunity (GO:0002714)2.60658233
121negative regulation of adaptive immune response (GO:0002820)2.59731149
122positive regulation of humoral immune response (GO:0002922)2.58205683
123granulocyte activation (GO:0036230)2.57926351
124lymphocyte homeostasis (GO:0002260)2.57501742
125T cell costimulation (GO:0031295)2.57114113
126dendritic cell chemotaxis (GO:0002407)2.56722320
127positive regulation of B cell activation (GO:0050871)2.56080894
128negative regulation of granulocyte differentiation (GO:0030853)2.55118864
129negative regulation of interleukin-12 production (GO:0032695)2.54786726
130mature B cell differentiation (GO:0002335)2.54742841
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54515185
132positive regulation by organism of defense response of other organism involved in symbiotic interact2.54515185
133modulation by symbiont of host immune response (GO:0052553)2.54515185
134positive regulation by symbiont of host defense response (GO:0052509)2.54515185
135modulation by symbiont of host defense response (GO:0052031)2.54515185
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54515185
137dendritic cell migration (GO:0036336)2.54149043
138lymphocyte costimulation (GO:0031294)2.52858636
139B cell homeostasis (GO:0001782)2.50862614
140regulation of granulocyte differentiation (GO:0030852)2.49800565
141regulation of B cell proliferation (GO:0030888)2.48200419
142regulation of regulatory T cell differentiation (GO:0045589)2.46549056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.07262385
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.32011534
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.03694851
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.96489646
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82550754
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.52353218
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.45418810
8E2F7_22180533_ChIP-Seq_HELA_Human3.42963733
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41478519
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38393068
11* SCL_19346495_ChIP-Seq_HPC-7_Human3.23785587
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20792944
13RUNX_20019798_ChIP-Seq_JUKART_Human3.03864942
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85035474
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.82477050
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.78024020
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70850781
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64248358
19GATA1_22025678_ChIP-Seq_K562_Human2.61164310
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58726206
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58562068
22* MYB_26560356_Chip-Seq_TH2_Human2.53081230
23MYC_22102868_ChIP-Seq_BL_Human2.36779028
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34998721
25MYB_26560356_Chip-Seq_TH1_Human2.34076832
26MAF_26560356_Chip-Seq_TH1_Human2.18938063
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10006947
28SPI1_23547873_ChIP-Seq_NB4_Human2.04602477
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99463380
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.97114083
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95337449
32VDR_21846776_ChIP-Seq_THP-1_Human1.93321436
33TCF7_22412390_ChIP-Seq_EML_Mouse1.93263758
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93042146
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.88152509
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86101109
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84615604
38UTX_26944678_Chip-Seq_JUKART_Human1.83348055
39VDR_24763502_ChIP-Seq_THP-1_Human1.79833376
40* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71850614
41SPI1_23127762_ChIP-Seq_K562_Human1.67525485
42* GATA2_21666600_ChIP-Seq_HMVEC_Human1.63296029
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.61562772
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53070031
45PU_27001747_Chip-Seq_BMDM_Mouse1.52301614
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50800980
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.47077686
48* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46983506
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42551530
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42212442
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40926056
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40103194
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.39523655
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38049969
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37866495
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36512508
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36122573
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31820822
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31493523
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30849405
61TP53_16413492_ChIP-PET_HCT116_Human1.28855095
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28265743
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27491992
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25647430
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24004652
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23861742
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23573240
68* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21490154
69MAF_26560356_Chip-Seq_TH2_Human1.20692713
70GATA3_26560356_Chip-Seq_TH2_Human1.19781217
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18983064
72AHR_22903824_ChIP-Seq_MCF-7_Human1.18810355
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18332273
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17274246
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15952842
76* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14529750
77* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12391066
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11740636
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10646183
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09047267
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08845105
82VDR_24787735_ChIP-Seq_THP-1_Human1.07654736
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07162640
84KDM2B_26808549_Chip-Seq_DND41_Human0.99914502
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.99754417
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99651645
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99041595
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98891741
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98692338
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98196681
91CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98128028
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97309063
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97168943
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96587207
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94640443
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.94121614
97SMRT_27268052_Chip-Seq_Bcells_Human0.94099090
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93355241
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92120862
100CIITA_25753668_ChIP-Seq_RAJI_Human0.92088433
101GATA2_19941826_ChIP-Seq_K562_Human0.91446619
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90102797
103AR_21572438_ChIP-Seq_LNCaP_Human0.90031410
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89147097
105FOXM1_23109430_ChIP-Seq_U2OS_Human0.88929290
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88328006
107NCOR1_26117541_ChIP-Seq_K562_Human0.88212865
108GATA1_19941826_ChIP-Seq_K562_Human0.88135680
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88104316
110E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87630863
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86526526
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84425331
113* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84332839
114* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84332839
115* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83702311
116* TBX20_22328084_ChIP-Seq_HEART_Mouse0.83536431
117* TBX20_22080862_ChIP-Seq_HEART_Mouse0.83536431
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.82870951
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81210056
120* FOXA2_19822575_ChIP-Seq_HepG2_Human0.81142293
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.80290262
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.79324104
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78479763
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77569441
125* TP63_23658742_ChIP-Seq_EP156T_Human0.77491826
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77285592
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77071112
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.76622085
129LXR_22158963_ChIP-Seq_LIVER_Mouse0.75818648
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.75387075
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74286034
132ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74110740
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72920911
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70061513
135ELK1_19687146_ChIP-ChIP_HELA_Human0.69374710
136* E2F1_21310950_ChIP-Seq_MCF-7_Human0.66800857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.80957989
2MP0005671_abnormal_response_to3.11932962
3MP0000685_abnormal_immune_system2.96350076
4MP0003763_abnormal_thymus_physiology2.93112180
5MP0002396_abnormal_hematopoietic_system2.88242712
6MP0001800_abnormal_humoral_immune2.76658410
7MP0001790_abnormal_immune_system2.72668988
8MP0005387_immune_system_phenotype2.72668988
9MP0009785_altered_susceptibility_to2.62789952
10MP0003436_decreased_susceptibility_to2.59373802
11MP0002166_altered_tumor_susceptibility2.56060841
12MP0005000_abnormal_immune_tolerance2.55441893
13MP0002452_abnormal_antigen_presenting2.44583600
14MP0002723_abnormal_immune_serum2.34931797
15MP0002420_abnormal_adaptive_immunity2.30753264
16MP0001819_abnormal_immune_cell2.29326189
17MP0002148_abnormal_hypersensitivity_rea2.28295733
18MP0005025_abnormal_response_to2.26597523
19MP0004808_abnormal_hematopoietic_stem2.21036454
20MP0002398_abnormal_bone_marrow2.19818192
21MP0003724_increased_susceptibility_to2.13589179
22MP0002419_abnormal_innate_immunity2.13169144
23MP0002006_tumorigenesis2.12871432
24MP0003300_gastrointestinal_ulcer2.00807527
25MP0002405_respiratory_system_inflammati1.98560983
26MP0000716_abnormal_immune_system1.96609306
27MP0005464_abnormal_platelet_physiology1.93900920
28MP0010155_abnormal_intestine_physiology1.93752550
29MP0005397_hematopoietic_system_phenotyp1.92763160
30MP0001545_abnormal_hematopoietic_system1.92763160
31MP0004510_myositis1.88166507
32MP0001853_heart_inflammation1.85178466
33MP0004381_abnormal_hair_follicle1.83151026
34MP0009278_abnormal_bone_marrow1.82991848
35MP0005451_abnormal_body_composition1.82731645
36MP0008260_abnormal_autophagy1.82709433
37MP0000689_abnormal_spleen_morphology1.79250396
38MP0001873_stomach_inflammation1.76983256
39MP0002722_abnormal_immune_system1.73072338
40MP0003303_peritoneal_inflammation1.71033483
41MP0004883_abnormal_blood_vessel1.68609163
42MP0004947_skin_inflammation1.68282833
43MP0009333_abnormal_splenocyte_physiolog1.67090215
44MP0002429_abnormal_blood_cell1.65710586
45MP0000703_abnormal_thymus_morphology1.62894377
46MP0002877_abnormal_melanocyte_morpholog1.59326992
47MP0006082_CNS_inflammation1.57671323
48MP0001845_abnormal_inflammatory_respons1.55808015
49MP0004084_abnormal_cardiac_muscle1.51395360
50MP0000465_gastrointestinal_hemorrhage1.47968217
51MP0000569_abnormal_digit_pigmentation1.47308106
52MP0004484_altered_response_of1.44599110
53MP0005174_abnormal_tail_pigmentation1.42166066
54MP0008057_abnormal_DNA_replication1.40755484
55MP0008004_abnormal_stomach_pH1.37136762
56MP0010352_gastrointestinal_tract_polyps1.34340293
57MP0001533_abnormal_skeleton_physiology1.33902750
58MP0002933_joint_inflammation1.32380916
59MP0003866_abnormal_defecation1.31515274
60MP0003828_pulmonary_edema1.30867445
61MP0001958_emphysema1.29418889
62MP0002332_abnormal_exercise_endurance1.27008643
63MP0005310_abnormal_salivary_gland1.25791188
64MP0005164_abnormal_response_to1.25430946
65MP0002138_abnormal_hepatobiliary_system1.22759457
66MP0000858_altered_metastatic_potential1.19159958
67MP0000490_abnormal_crypts_of1.16399218
68MP0002009_preneoplasia1.16360932
69MP0004036_abnormal_muscle_relaxation1.15766272
70MP0003448_altered_tumor_morphology1.13414497
71MP0004130_abnormal_muscle_cell1.12129841
72MP0003943_abnormal_hepatobiliary_system1.10793637
73MP0008469_abnormal_protein_level1.10793626
74MP0006054_spinal_hemorrhage1.09941435
75MP0003183_abnormal_peptide_metabolism1.06745735
76MP0003566_abnormal_cell_adhesion1.06374035
77MP0002998_abnormal_bone_remodeling1.05603158
78MP0005075_abnormal_melanosome_morpholog1.03646635
79MP0003279_aneurysm1.02101681
80MP0003045_fibrosis1.01717053
81MP0001879_abnormal_lymphatic_vessel1.00026278
82MP0003656_abnormal_erythrocyte_physiolo0.99014787
83MP0009764_decreased_sensitivity_to0.96665515
84MP0003646_muscle_fatigue0.95515157
85MP0003690_abnormal_glial_cell0.92893431
86MP0000343_altered_response_to0.92788444
87MP0005076_abnormal_cell_differentiation0.89602332
88MP0000767_abnormal_smooth_muscle0.87802185
89MP0009115_abnormal_fat_cell0.87584003
90MP0002928_abnormal_bile_duct0.87382642
91MP0010368_abnormal_lymphatic_system0.85412510
92MP0004264_abnormal_extraembryonic_tissu0.85246632
93MP0002019_abnormal_tumor_incidence0.84587290
94MP0005388_respiratory_system_phenotype0.84329858
95MP0002133_abnormal_respiratory_system0.84329858
96MP0005390_skeleton_phenotype0.79347563
97MP0005023_abnormal_wound_healing0.78549451
98MP0003221_abnormal_cardiomyocyte_apopto0.77998839
99MP0003191_abnormal_cellular_cholesterol0.77084978
100MP0002168_other_aberrant_phenotype0.76914412
101MP0005409_darkened_coat_color0.76734895
102MP0005166_decreased_susceptibility_to0.76588148
103MP0001851_eye_inflammation0.76574447
104MP0000249_abnormal_blood_vessel0.75004217
105MP0002095_abnormal_skin_pigmentation0.74165804
106MP0003091_abnormal_cell_migration0.73693088
107MP0000371_diluted_coat_color0.73445694
108MP0008007_abnormal_cellular_replicative0.73247383
109MP0002254_reproductive_system_inflammat0.72579103
110MP0005058_abnormal_lysosome_morphology0.71919461
111MP0010307_abnormal_tumor_latency0.71857872
112MP0006138_congestive_heart_failure0.71200522
113MP0004782_abnormal_surfactant_physiolog0.70496572
114MP0003795_abnormal_bone_structure0.69431189
115MP0010630_abnormal_cardiac_muscle0.69409033
116MP0009763_increased_sensitivity_to0.68999270
117MP0002132_abnormal_respiratory_system0.68365249
118MP0008961_abnormal_basal_metabolism0.68026303
119MP0000604_amyloidosis0.64910650
120MP0000015_abnormal_ear_pigmentation0.61624412
121MP0002060_abnormal_skin_morphology0.60812968
122MP0001243_abnormal_dermal_layer0.59958853
123MP0001915_intracranial_hemorrhage0.58361142
124MP0003172_abnormal_lysosome_physiology0.58010584
125MP0002693_abnormal_pancreas_physiology0.58003384

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.23357790
2Myositis (HP:0100614)4.00809064
3Recurrent viral infections (HP:0004429)4.00476574
4Recurrent fungal infections (HP:0002841)3.83593044
5Elevated erythrocyte sedimentation rate (HP:0003565)3.82898872
6T lymphocytopenia (HP:0005403)3.80092542
7Eczematoid dermatitis (HP:0000976)3.75012722
8Abnormality of T cell number (HP:0011839)3.74917918
9Recurrent abscess formation (HP:0002722)3.67095276
10Orchitis (HP:0100796)3.47381357
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.44909242
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.41597049
13Retrobulbar optic neuritis (HP:0100654)3.41347063
14Optic neuritis (HP:0100653)3.41347063
15Recurrent bacterial skin infections (HP:0005406)3.34243394
16IgM deficiency (HP:0002850)3.33296120
17Abnormality of T cells (HP:0002843)3.14180001
18Chronic otitis media (HP:0000389)3.14145445
19Recurrent bronchitis (HP:0002837)3.11055458
20Agammaglobulinemia (HP:0004432)3.10618586
21Panhypogammaglobulinemia (HP:0003139)3.05912501
22Vasculitis (HP:0002633)3.05540223
23Autoimmune thrombocytopenia (HP:0001973)2.99046290
24Meningitis (HP:0001287)2.97031087
25Arterial thrombosis (HP:0004420)2.96433338
26Cellulitis (HP:0100658)2.88075273
27Thrombocytosis (HP:0001894)2.87002243
28Recurrent cutaneous fungal infections (HP:0011370)2.86745410
29Chronic mucocutaneous candidiasis (HP:0002728)2.86745410
30Prolonged bleeding time (HP:0003010)2.86478324
31Thyroiditis (HP:0100646)2.86036933
32Spontaneous hematomas (HP:0007420)2.84308605
33Mediastinal lymphadenopathy (HP:0100721)2.81210181
34Pulmonary infiltrates (HP:0002113)2.76142251
35Inflammation of the large intestine (HP:0002037)2.71531575
36Periodontitis (HP:0000704)2.70377362
37Absent frontal sinuses (HP:0002688)2.70262773
38Chronic diarrhea (HP:0002028)2.69117910
39Eosinophilia (HP:0001880)2.67750215
40Acute myeloid leukemia (HP:0004808)2.67051425
41Abnormality of T cell physiology (HP:0011840)2.67009052
42Gastrointestinal inflammation (HP:0004386)2.62848022
43Leukocytosis (HP:0001974)2.60721653
44Colitis (HP:0002583)2.54726520
45Keratoconjunctivitis sicca (HP:0001097)2.51043799
46Recurrent skin infections (HP:0001581)2.49035054
47IgA deficiency (HP:0002720)2.47182970
48Gingival bleeding (HP:0000225)2.46902907
49Abnormality of eosinophils (HP:0001879)2.46144646
50B lymphocytopenia (HP:0010976)2.45403584
51Abnormality of B cell number (HP:0010975)2.45403584
52Hemoptysis (HP:0002105)2.45069660
53Granulocytopenia (HP:0001913)2.44317060
54Chest pain (HP:0100749)2.43823387
55Encephalitis (HP:0002383)2.43477763
56Epistaxis (HP:0000421)2.42873536
57Gastrointestinal infarctions (HP:0005244)2.41827779
58Abnormality of the prostate (HP:0008775)2.39667920
59Pustule (HP:0200039)2.39567921
60Aortic aneurysm (HP:0004942)2.36821402
61Lymphopenia (HP:0001888)2.35973972
62Severe combined immunodeficiency (HP:0004430)2.35020377
63Syringomyelia (HP:0003396)2.35019639
64Spinal cord lesions (HP:0100561)2.35019639
65IgG deficiency (HP:0004315)2.34500146
66Hematochezia (HP:0002573)2.31848603
67Nasal polyposis (HP:0100582)2.31489771
68Combined immunodeficiency (HP:0005387)2.29074896
69Petechiae (HP:0000967)2.26061897
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.25346707
71Subacute progressive viral hepatitis (HP:0006572)2.23730266
72Keratoconjunctivitis (HP:0001096)2.22635280
73Peritonitis (HP:0002586)2.21803736
74Spondylolisthesis (HP:0003302)2.21134105
75Abnormality of the nasal mucosa (HP:0000433)2.20877939
76Gingivitis (HP:0000230)2.20500524
77Gastrointestinal stroma tumor (HP:0100723)2.20269591
78Viral hepatitis (HP:0006562)2.20216983
79Neoplasm of the tracheobronchial system (HP:0100552)2.19497367
80Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17101501
81Recurrent gram-negative bacterial infections (HP:0005420)2.16966923
82Pulmonary embolism (HP:0002204)2.16062428
83Osteomyelitis (HP:0002754)2.14305094
84Volvulus (HP:0002580)2.13270917
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.13071757
86Osteolytic defects of the hand bones (HP:0009699)2.13071757
87Abnormality of the endocardium (HP:0004306)2.10974586
88Slow saccadic eye movements (HP:0000514)2.10038751
89Interstitial pulmonary disease (HP:0006530)2.08006159
90Obstructive lung disease (HP:0006536)2.07768730
91Chronic obstructive pulmonary disease (HP:0006510)2.07768730
92Long eyelashes (HP:0000527)2.07099020
93Abnormality of macrophages (HP:0004311)2.02215415
94Hyporeflexia of lower limbs (HP:0002600)2.01128939
95Urticaria (HP:0001025)1.97981825
96Abnormality of the pleura (HP:0002103)1.97977652
97Increased IgE level (HP:0003212)1.96662757
98Hypoplasia of the thymus (HP:0000778)1.95879390
99Papilledema (HP:0001085)1.95081704
100Neonatal hypoglycemia (HP:0001998)1.94811868
101Abnormality of the peritoneum (HP:0002585)1.94031229
102Abnormal platelet volume (HP:0011876)1.93307889
103Stomatitis (HP:0010280)1.91388689
104Amaurosis fugax (HP:0100576)1.90843554
105Difficulty running (HP:0009046)1.90841390
106Autoimmune hemolytic anemia (HP:0001890)1.90608714
107Lymphoma (HP:0002665)1.90302134
108Alveolar cell carcinoma (HP:0006519)1.90195458
109Muscle fiber splitting (HP:0003555)1.90052366
110Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.88576406
111Impaired platelet aggregation (HP:0003540)1.88134873
112Abnormal platelet function (HP:0011869)1.88134873
113Lip pit (HP:0100267)1.86980573
114Emphysema (HP:0002097)1.86744062
115Papilloma (HP:0012740)1.86730843
116Verrucae (HP:0200043)1.86730843
117Prostate neoplasm (HP:0100787)1.86273649
118Stomach cancer (HP:0012126)1.85203201
119Gangrene (HP:0100758)1.83860324
120Increased IgM level (HP:0003496)1.83441592
121Vertigo (HP:0002321)1.79820305
122Joint swelling (HP:0001386)1.76939945
123Fatigue (HP:0012378)1.74739811
124Restrictive lung disease (HP:0002091)1.74350994
125Conjunctival telangiectasia (HP:0000524)1.71533310
126Narrow palate (HP:0000189)1.70431793
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69769419
128Amyloidosis (HP:0011034)1.68140109
129Genetic anticipation (HP:0003743)1.67436921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.09321042
2TXK3.55866253
3MAP3K142.94425177
4JAK32.75728279
5KIT2.24541340
6IRAK42.23883749
7TYK22.15341712
8IKBKE2.12944251
9CDK122.12302499
10TEC2.11260009
11ITK2.06378820
12FGFR32.00265701
13ZAP701.93464220
14STK101.90640645
15BTK1.90338200
16IKBKB1.89053473
17JAK11.82584960
18TBK11.81772658
19MAP2K31.81120542
20TGFBR21.79668559
21IRAK31.78430792
22PRPF4B1.76579268
23TAOK31.75370891
24CHUK1.71897225
25CSF1R1.55457618
26FLT31.49186168
27FGFR41.47007690
28SYK1.41335576
29ERN11.40460338
30NLK1.39496080
31PIM11.32837979
32STK241.31039884
33GRK61.29069608
34CSK1.26761923
35MARK21.26035733
36LCK1.24480757
37CDC42BPA1.23650702
38FGR1.23261845
39HCK1.20847664
40AKT31.19816558
41TRPM71.19677885
42MAP3K31.18347123
43MAP3K101.17449945
44BLK1.17280646
45NEK91.10070997
46BMPR21.08038064
47RPS6KA41.05762537
48NUAK11.02538957
49STK41.02245553
50EPHB11.01783166
51TIE11.01556806
52CAMK1D1.00584251
53SIK31.00241541
54WNK10.98544483
55MAP3K130.97704371
56BRD40.95288978
57EEF2K0.94761764
58EPHA30.91264328
59MELK0.90408982
60INSRR0.90088196
61MAPK120.90016413
62MAP3K10.88180808
63RIPK40.86535377
64LYN0.85795806
65MAP3K60.85717245
66PTK2B0.85388685
67MAP3K20.81218944
68OBSCN0.81207662
69SGK2230.80351728
70SGK4940.80351728
71PDK10.79667869
72HIPK20.79626140
73MATK0.76493301
74JAK20.75441376
75CDK60.75326242
76CLK10.74221103
77ZAK0.73932841
78CAMK1G0.73900444
79FRK0.73143801
80LRRK20.69995733
81PRKCQ0.68436315
82YES10.67152983
83MAPK70.66589386
84MARK30.65748096
85RET0.64525006
86TTN0.63407542
87MAPK110.63321894
88PTK60.62938882
89ACVR1B0.62139525
90CAMKK20.61219031
91PIK3CA0.61186010
92STK30.60975430
93MST40.60898551
94SGK30.58486669
95CDK90.57372476
96PRKCH0.57149720
97PDGFRB0.56316518
98PRKAA20.55799147
99PRKD20.55713565
100DMPK0.54427949
101RIPK10.53427130
102TGFBR10.52700478
103CDK40.52625855
104STK110.52012952
105EGFR0.51050908
106ERBB20.50119535
107GRK70.49987000
108STK380.49981922
109PDPK10.49149518
110PKN20.48676462
111RPS6KA60.46709495
112FYN0.46377226
113SGK20.45999474
114MAP3K70.45810389
115IGF1R0.45263175
116TNK20.45024624
117PIM20.44229598
118MAP3K50.44167754
119NEK60.44052096
120IRAK20.43753911
121MAPKAPK20.43702021
122ATR0.43546646
123PRKD10.43114906
124TRIB30.40729738
125IRAK10.39920267
126FES0.38485219
127RPS6KB20.37477071
128PIK3CG0.37465041
129MAPK30.37139908
130SIK10.37053297
131PASK0.35421817
132RPS6KA50.35383771
133ABL10.35284065
134CAMK40.34324441

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.22666516
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.66852686
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.55921270
4Leishmaniasis_Homo sapiens_hsa051402.55592547
5Measles_Homo sapiens_hsa051622.41611828
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38222717
7Allograft rejection_Homo sapiens_hsa053302.29930394
8B cell receptor signaling pathway_Homo sapiens_hsa046622.20760112
9Graft-versus-host disease_Homo sapiens_hsa053322.11902852
10Osteoclast differentiation_Homo sapiens_hsa043802.09230820
11Hematopoietic cell lineage_Homo sapiens_hsa046402.03842211
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01686986
13T cell receptor signaling pathway_Homo sapiens_hsa046601.90016852
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88959711
15Antigen processing and presentation_Homo sapiens_hsa046121.79910026
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.77840076
17Herpes simplex infection_Homo sapiens_hsa051681.77220185
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74907727
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69710468
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65106163
21Toxoplasmosis_Homo sapiens_hsa051451.63144932
22Influenza A_Homo sapiens_hsa051641.59262428
23TNF signaling pathway_Homo sapiens_hsa046681.59260883
24Acute myeloid leukemia_Homo sapiens_hsa052211.54568375
25Viral myocarditis_Homo sapiens_hsa054161.48933310
26Legionellosis_Homo sapiens_hsa051341.45221378
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42139649
28Malaria_Homo sapiens_hsa051441.38692208
29Autoimmune thyroid disease_Homo sapiens_hsa053201.38064263
30Hepatitis B_Homo sapiens_hsa051611.36822025
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32333021
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30170597
33Chronic myeloid leukemia_Homo sapiens_hsa052201.28128557
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26864590
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.24793020
36Chemokine signaling pathway_Homo sapiens_hsa040621.23259008
37Staphylococcus aureus infection_Homo sapiens_hsa051501.22348269
38Pertussis_Homo sapiens_hsa051331.21935657
39Apoptosis_Homo sapiens_hsa042101.20249082
40Platelet activation_Homo sapiens_hsa046111.17766092
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17387619
42Tuberculosis_Homo sapiens_hsa051521.15329910
43Type I diabetes mellitus_Homo sapiens_hsa049401.14667309
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11180643
45Shigellosis_Homo sapiens_hsa051311.07693149
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06170635
47Asthma_Homo sapiens_hsa053101.04382201
48Small cell lung cancer_Homo sapiens_hsa052221.03290061
49Renal cell carcinoma_Homo sapiens_hsa052110.99033237
50Pancreatic cancer_Homo sapiens_hsa052120.97571175
51Prolactin signaling pathway_Homo sapiens_hsa049170.95875506
52Hepatitis C_Homo sapiens_hsa051600.93890491
53HTLV-I infection_Homo sapiens_hsa051660.91837631
54Non-homologous end-joining_Homo sapiens_hsa034500.89764988
55Endometrial cancer_Homo sapiens_hsa052130.88284695
56Other glycan degradation_Homo sapiens_hsa005110.87715043
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87467933
58VEGF signaling pathway_Homo sapiens_hsa043700.84260082
59Viral carcinogenesis_Homo sapiens_hsa052030.82058585
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78794640
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.78138493
62Choline metabolism in cancer_Homo sapiens_hsa052310.77931017
63African trypanosomiasis_Homo sapiens_hsa051430.77688438
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.76844200
65Salmonella infection_Homo sapiens_hsa051320.75816211
66MicroRNAs in cancer_Homo sapiens_hsa052060.72155108
67Phagosome_Homo sapiens_hsa041450.71539498
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71461086
69Non-small cell lung cancer_Homo sapiens_hsa052230.71056768
70Epstein-Barr virus infection_Homo sapiens_hsa051690.71012936
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.70942270
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70592020
73Insulin resistance_Homo sapiens_hsa049310.70437923
74Base excision repair_Homo sapiens_hsa034100.70014001
75GnRH signaling pathway_Homo sapiens_hsa049120.69814483
76Caffeine metabolism_Homo sapiens_hsa002320.69436597
77FoxO signaling pathway_Homo sapiens_hsa040680.67879580
78Lysine degradation_Homo sapiens_hsa003100.67091262
79Circadian rhythm_Homo sapiens_hsa047100.66588432
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.66397198
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65666141
82p53 signaling pathway_Homo sapiens_hsa041150.64562984
83Prostate cancer_Homo sapiens_hsa052150.64158649
84Notch signaling pathway_Homo sapiens_hsa043300.62097540
85Type II diabetes mellitus_Homo sapiens_hsa049300.61081903
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59800996
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.59500775
88Rheumatoid arthritis_Homo sapiens_hsa053230.58412217
89Adherens junction_Homo sapiens_hsa045200.56922464
90Thyroid cancer_Homo sapiens_hsa052160.55631916
91Glioma_Homo sapiens_hsa052140.53963409
92ErbB signaling pathway_Homo sapiens_hsa040120.53565941
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53393777
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51501499
95Focal adhesion_Homo sapiens_hsa045100.51390317
96ABC transporters_Homo sapiens_hsa020100.51176973
97Amoebiasis_Homo sapiens_hsa051460.49549172
98Renin secretion_Homo sapiens_hsa049240.49257930
99Complement and coagulation cascades_Homo sapiens_hsa046100.48322405
100Proteoglycans in cancer_Homo sapiens_hsa052050.47731371
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46989995
102Dilated cardiomyopathy_Homo sapiens_hsa054140.46672354
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46137771
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.45966169
105Estrogen signaling pathway_Homo sapiens_hsa049150.45226446
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44702543
107Pathways in cancer_Homo sapiens_hsa052000.44597344
108HIF-1 signaling pathway_Homo sapiens_hsa040660.42696402
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41982904
110Inositol phosphate metabolism_Homo sapiens_hsa005620.41839295
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39238098
112RNA degradation_Homo sapiens_hsa030180.38698238
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37723383
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37249926
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35603032
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34790198
117ECM-receptor interaction_Homo sapiens_hsa045120.34714319
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34503007
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34469786
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33978120
121Colorectal cancer_Homo sapiens_hsa052100.33044161
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32894839
123MAPK signaling pathway_Homo sapiens_hsa040100.32344606
124mTOR signaling pathway_Homo sapiens_hsa041500.31816054

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