AKAP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.62870615
2axoneme assembly (GO:0035082)9.22177257
3epithelial cilium movement (GO:0003351)8.82716648
4GTP biosynthetic process (GO:0006183)8.34264172
5UTP biosynthetic process (GO:0006228)7.35961485
6bone trabecula formation (GO:0060346)7.32275815
7centriole assembly (GO:0098534)7.30456232
8ventricular system development (GO:0021591)7.02427500
9nucleoside diphosphate phosphorylation (GO:0006165)6.79344905
10UTP metabolic process (GO:0046051)6.72600148
11left/right axis specification (GO:0070986)6.46696669
12motile cilium assembly (GO:0044458)6.16579243
13response to parathyroid hormone (GO:0071107)5.96396830
14positive regulation of hair cycle (GO:0042635)5.78653841
15positive regulation of hair follicle development (GO:0051798)5.78653841
16multicellular organism reproduction (GO:0032504)5.63997549
17glycine transport (GO:0015816)5.59175567
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.54759136
19response to water (GO:0009415)5.38839844
20protein localization to cilium (GO:0061512)5.27214918
21CTP biosynthetic process (GO:0006241)5.25176355
22CTP metabolic process (GO:0046036)5.25176355
23detection of calcium ion (GO:0005513)5.20410699
24positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)5.20087192
25positive regulation of cell cycle G2/M phase transition (GO:1902751)5.20087192
26positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)5.14343436
27guanosine-containing compound biosynthetic process (GO:1901070)5.09199001
28sperm capacitation (GO:0048240)4.93256652
29L-amino acid import (GO:0043092)4.89245333
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.83077963
31pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.73693573
32primary alcohol catabolic process (GO:0034310)4.68138414
33inner ear receptor cell development (GO:0060119)4.66142602
34lateral ventricle development (GO:0021670)4.45237021
35pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.42564314
36positive regulation of DNA-templated transcription, initiation (GO:2000144)4.42043066
37central nervous system myelination (GO:0022010)4.39921055
38axon ensheathment in central nervous system (GO:0032291)4.39921055
39hematopoietic stem cell proliferation (GO:0071425)4.39594095
40determination of left/right symmetry (GO:0007368)4.38240105
41pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.33882588
42microtubule bundle formation (GO:0001578)4.31211038
43acrosome reaction (GO:0007340)4.30011420
44cilium organization (GO:0044782)4.29389333
45reproduction (GO:0000003)4.22628209
46positive regulation of fibroblast migration (GO:0010763)4.20411419
47determination of bilateral symmetry (GO:0009855)4.18760424
48photoreceptor cell differentiation (GO:0046530)4.15529277
49eye photoreceptor cell differentiation (GO:0001754)4.15529277
50reflex (GO:0060004)4.14345588
51specification of symmetry (GO:0009799)4.13150814
52vitamin transmembrane transport (GO:0035461)4.13113919
53diterpenoid biosynthetic process (GO:0016102)4.08706682
54nucleotide phosphorylation (GO:0046939)4.06710450
55cilium assembly (GO:0042384)4.06555033
56microtubule severing (GO:0051013)4.00080586
57regulation of microtubule-based movement (GO:0060632)3.99713173
58regulation of hair follicle development (GO:0051797)3.96866601
59intraciliary transport (GO:0042073)3.93053254
60regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.92129049
61ethanol metabolic process (GO:0006067)3.91220573
62sperm-egg recognition (GO:0035036)3.81771421
63cilium morphogenesis (GO:0060271)3.79596694
64fusion of sperm to egg plasma membrane (GO:0007342)3.78036847
65pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.75822124
66amino acid import (GO:0043090)3.73572223
67cell wall macromolecule metabolic process (GO:0044036)3.70738195
68cell wall macromolecule catabolic process (GO:0016998)3.70738195
69smoothened signaling pathway (GO:0007224)3.66263586
70cellular component assembly involved in morphogenesis (GO:0010927)3.63471071
71one-carbon compound transport (GO:0019755)3.59283880
72response to gravity (GO:0009629)3.58917448
73negative regulation of myoblast differentiation (GO:0045662)3.55507794
74sperm motility (GO:0030317)3.52306065
75pyrimidine-containing compound transmembrane transport (GO:0072531)3.51438900
76single fertilization (GO:0007338)3.49123249
77negative regulation of T cell differentiation in thymus (GO:0033085)3.48005694
78skeletal muscle fiber development (GO:0048741)3.44842962
79nonmotile primary cilium assembly (GO:0035058)3.43484741
80regulation of cilium movement (GO:0003352)3.40046888
81glomerular epithelial cell development (GO:0072310)3.39789699
82intra-S DNA damage checkpoint (GO:0031573)3.38982748
83piRNA metabolic process (GO:0034587)3.37405579
84establishment of apical/basal cell polarity (GO:0035089)3.35084978
85cell-cell recognition (GO:0009988)3.33147605
86DNA methylation involved in gamete generation (GO:0043046)3.32967776
87acrosome assembly (GO:0001675)3.32864062
88NAD biosynthetic process (GO:0009435)3.32121351
89regulation of DNA-templated transcription, initiation (GO:2000142)3.30503349
90lung epithelium development (GO:0060428)3.29268151
91tolerance induction (GO:0002507)3.27473316
92establishment or maintenance of monopolar cell polarity (GO:0061339)3.22614387
93establishment of monopolar cell polarity (GO:0061162)3.22614387
94nephron tubule formation (GO:0072079)3.14709593
95regulation of collateral sprouting (GO:0048670)3.13481942
96microtubule-based movement (GO:0007018)3.12024370
97cytoplasmic microtubule organization (GO:0031122)3.11826383
98nucleoside diphosphate metabolic process (GO:0009132)3.10846505
99exogenous drug catabolic process (GO:0042738)3.09215415
100activated T cell proliferation (GO:0050798)3.07339317
101myotube cell development (GO:0014904)3.05799770
102microtubule-based process (GO:0007017)3.04270120
103glutathione derivative metabolic process (GO:1901685)3.03949422
104glutathione derivative biosynthetic process (GO:1901687)3.03949422
105cell projection assembly (GO:0030031)3.03753309
106Sertoli cell development (GO:0060009)3.03594922
107establishment of planar polarity (GO:0001736)3.03063344
108establishment of tissue polarity (GO:0007164)3.03063344
109terpenoid biosynthetic process (GO:0016114)3.01645385
110pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.99669348
111microtubule depolymerization (GO:0007019)2.98385457
112regulation of interleukin-5 production (GO:0032674)2.97113645
113ethanol oxidation (GO:0006069)2.96812658
114detection of mechanical stimulus involved in sensory perception (GO:0050974)2.95226703
115regulation of hair cycle (GO:0042634)2.93516415
116organelle assembly (GO:0070925)2.91691482
117glomerulus development (GO:0032835)2.91186326
118retinoic acid metabolic process (GO:0042573)2.87762369
119lateral sprouting from an epithelium (GO:0060601)2.87732883
120pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.87415126
121regulation of macrophage chemotaxis (GO:0010758)2.86554354
122plasma membrane fusion (GO:0045026)2.86103481
123centriole replication (GO:0007099)2.84655411
124response to hepatocyte growth factor (GO:0035728)2.84285802
125cellular response to hepatocyte growth factor stimulus (GO:0035729)2.84285802
126negative regulation of inclusion body assembly (GO:0090084)2.82587237
127response to xenobiotic stimulus (GO:0009410)2.80508057
128spermatid nucleus differentiation (GO:0007289)2.80452278
129superoxide anion generation (GO:0042554)2.79527404
130negative regulation of neurotransmitter transport (GO:0051589)2.76894257
131fertilization (GO:0009566)2.73321307
132retinol metabolic process (GO:0042572)2.72907265
133pyrimidine ribonucleotide metabolic process (GO:0009218)2.71447437
134oligodendrocyte differentiation (GO:0048709)2.71375752
135ADP metabolic process (GO:0046031)2.70020918
136chemosensory behavior (GO:0007635)2.69297731
137retinal rod cell development (GO:0046548)2.68288224
138negative regulation of B cell mediated immunity (GO:0002713)2.67842029
139negative regulation of immunoglobulin mediated immune response (GO:0002890)2.67842029
140regulation of autophagic vacuole assembly (GO:2000785)2.67800068
141apical protein localization (GO:0045176)2.66488727
142positive regulation of smoothened signaling pathway (GO:0045880)2.65136305
143negative regulation of humoral immune response (GO:0002921)2.64138145
144microtubule polymerization or depolymerization (GO:0031109)2.58304067
145primary alcohol metabolic process (GO:0034308)2.52911832
146positive regulation of tolerance induction (GO:0002645)2.45076623
147regulation of vacuole organization (GO:0044088)2.42602847
148regulation of germinal center formation (GO:0002634)2.42200299
149heart looping (GO:0001947)2.40393688
150regulation of podosome assembly (GO:0071801)2.40189932
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.38463699
152photoreceptor cell maintenance (GO:0045494)2.38142830
153phenol-containing compound catabolic process (GO:0019336)2.38082049
154asymmetric protein localization (GO:0008105)2.34167702
155protein polyglutamylation (GO:0018095)2.31266659
156embryonic heart tube morphogenesis (GO:0003143)2.30552096
157regulation of interleukin-13 production (GO:0032656)2.29041070
158regulation of smoothened signaling pathway (GO:0008589)2.26780396
159hydrogen peroxide biosynthetic process (GO:0050665)2.24674426
160O-glycan processing (GO:0016266)2.22516164
161carnitine metabolic process (GO:0009437)2.22225875
162spermatid development (GO:0007286)2.19071394
163gas transport (GO:0015669)2.17823371
164aldehyde catabolic process (GO:0046185)2.14602265
165cilium movement (GO:0003341)11.4673693
166cilium or flagellum-dependent cell motility (GO:0001539)10.5727214
167axonemal dynein complex assembly (GO:0070286)10.1328455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03272302
2EZH2_22144423_ChIP-Seq_EOC_Human3.42682656
3GBX2_23144817_ChIP-Seq_PC3_Human2.85019811
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.65182214
5PCGF2_27294783_Chip-Seq_NPCs_Mouse2.63956748
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.50887384
7SUZ12_27294783_Chip-Seq_NPCs_Mouse2.44362259
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.39919312
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.33518230
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32809354
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26247589
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23642002
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.21400857
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.09016327
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05085560
16EZH2_27294783_Chip-Seq_NPCs_Mouse1.98480916
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91129872
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90501728
19TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89591645
20AHR_22903824_ChIP-Seq_MCF-7_Human1.84685348
21EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.83954401
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81593307
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.81168005
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.76900853
25VDR_22108803_ChIP-Seq_LS180_Human1.72057244
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70968292
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.70897113
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70556867
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70556867
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.70422078
31FUS_26573619_Chip-Seq_HEK293_Human1.70297695
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69633174
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66605028
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.66334614
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.65893175
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65475909
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65127081
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64811204
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.64019242
40P53_22387025_ChIP-Seq_ESCs_Mouse1.63976393
41EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62304415
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62222175
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61666867
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60286615
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.58433578
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57977651
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56363883
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56034832
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.55695722
50IRF1_19129219_ChIP-ChIP_H3396_Human1.54883077
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.54748978
52P300_18555785_Chip-Seq_ESCs_Mouse1.54439695
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.52692052
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.51910145
55ZFX_18555785_Chip-Seq_ESCs_Mouse1.51503300
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.51146589
57ESRRB_18555785_Chip-Seq_ESCs_Mouse1.47465395
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.47418221
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45934192
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.43983773
61PU1_27457419_Chip-Seq_LIVER_Mouse1.43964639
62RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42774011
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42627798
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42627798
65TAF15_26573619_Chip-Seq_HEK293_Human1.42350112
66RNF2_27304074_Chip-Seq_NSC_Mouse1.41446943
67AR_21572438_ChIP-Seq_LNCaP_Human1.40955990
68BCAT_22108803_ChIP-Seq_LS180_Human1.40893812
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40798382
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.40560900
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39790851
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39378348
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39214674
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38665642
75TP63_23658742_ChIP-Seq_EP156T_Human1.38445051
76DROSHA_22980978_ChIP-Seq_HELA_Human1.38371348
77SMAD4_21799915_ChIP-Seq_A2780_Human1.38115809
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.37991040
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37763922
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37391754
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.37377885
82TCF4_22108803_ChIP-Seq_LS180_Human1.36344463
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36314879
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36293752
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.35260109
86TP53_18474530_ChIP-ChIP_U2OS_Human1.35199964
87P300_19829295_ChIP-Seq_ESCs_Human1.35040178
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34760593
89ETV1_20927104_ChIP-Seq_GIST48_Human1.34225089
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34003178
91PHF8_20622853_ChIP-Seq_HELA_Human1.33434666
92REST_21632747_ChIP-Seq_MESCs_Mouse1.32501262
93ER_23166858_ChIP-Seq_MCF-7_Human1.32254724
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30622609
95SMAD1_18555785_Chip-Seq_ESCs_Mouse1.30403344
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30337315
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29815012
98KDM2B_26808549_Chip-Seq_REH_Human1.28751287
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28717454
100STAT1_20625510_ChIP-Seq_HELA_Human1.28709894
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.28574474
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.28084847
103PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.27906129
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26120458
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26015652
106CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25460715
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23953605
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22615509
109CBP_20019798_ChIP-Seq_JUKART_Human1.22615509
110SMRT_27268052_Chip-Seq_Bcells_Human1.22491548
111STAT3_23295773_ChIP-Seq_U87_Human1.20844707
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19901590
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19719214
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19087079
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19075075
116TCF4_23295773_ChIP-Seq_U87_Human1.18131626
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17559596
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17503671
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17142062
120HNFA_21074721_ChIP-Seq_CACO-2_Human1.16183258
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15992455
122LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15784076
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15300118
124RNF2_27304074_Chip-Seq_ESCs_Mouse1.14927886
125NFYA_21822215_ChIP-Seq_K562_Human1.14832965
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13612762
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13464328
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12545015
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12228759
130TRIM28_21343339_ChIP-Seq_HEK293_Human1.12100376
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.10605673
132ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09702494
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.09278784
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09111835
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08776484
136TBL1_22424771_ChIP-Seq_293T_Human1.08094713
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07474301
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07469811
139* RUNX2_22187159_ChIP-Seq_PCA_Human1.05727288
140CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05372739
141NFYB_21822215_ChIP-Seq_K562_Human1.04938019
142FOXA1_25552417_ChIP-Seq_VCAP_Human1.04782673
143EWS_26573619_Chip-Seq_HEK293_Human1.04249486
144CBP_21632823_ChIP-Seq_H3396_Human1.03649695
145ERG_20517297_ChIP-Seq_VCAP_Human1.03442898
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03001131
147SMC4_20622854_ChIP-Seq_HELA_Human1.01408497
148CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01289316
149AR_20517297_ChIP-Seq_VCAP_Human0.99408686
150TP63_22573176_ChIP-Seq_HFKS_Human0.98548997
151RBPJ_21746931_ChIP-Seq_IB4_Human0.97336163
152AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96483069
153CDX2_22108803_ChIP-Seq_LS180_Human0.95899986
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95894580
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95489382
156TP53_16413492_ChIP-PET_HCT116_Human0.95431234
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.95305497
158FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95305497
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95241663
160TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93573252
161SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93503318
162GATA6_21074721_ChIP-Seq_CACO-2_Human0.93401289
163GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92595260
164P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92252530
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92138508
166RXR_22108803_ChIP-Seq_LS180_Human0.91601524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology6.67673466
2MP0005410_abnormal_fertilization4.98531804
3MP0008875_abnormal_xenobiotic_pharmacok4.14320049
4MP0001984_abnormal_olfaction4.13949303
5MP0003195_calcinosis4.10170771
6MP0005623_abnormal_meninges_morphology3.56789173
7MP0002132_abnormal_respiratory_system3.25500122
8MP0005377_hearing/vestibular/ear_phenot3.21237470
9MP0003878_abnormal_ear_physiology3.21237470
10MP0001188_hyperpigmentation3.04379083
11MP0003136_yellow_coat_color2.99879965
12MP0008789_abnormal_olfactory_epithelium2.83034985
13MP0004742_abnormal_vestibular_system2.81886823
14MP0004043_abnormal_pH_regulation2.73161057
15MP0003806_abnormal_nucleotide_metabolis2.55101014
16MP0001440_abnormal_grooming_behavior2.47173419
17MP0010030_abnormal_orbit_morphology2.45035531
18MP0000750_abnormal_muscle_regeneration2.39495330
19MP0004142_abnormal_muscle_tone2.38526197
20MP0009384_cardiac_valve_regurgitation2.23981687
21MP0004019_abnormal_vitamin_homeostasis2.16501250
22MP0005499_abnormal_olfactory_system2.11814446
23MP0005394_taste/olfaction_phenotype2.11814446
24MP0002277_abnormal_respiratory_mucosa2.06190533
25MP0003698_abnormal_male_reproductive2.04099299
26MP0009046_muscle_twitch2.03005502
27MP0006072_abnormal_retinal_apoptosis1.98535358
28MP0001486_abnormal_startle_reflex1.97425920
29MP0002653_abnormal_ependyma_morphology1.89430412
30MP0004133_heterotaxia1.88062140
31MP0002736_abnormal_nociception_after1.87636489
32MP0003879_abnormal_hair_cell1.85956290
33MP0004858_abnormal_nervous_system1.83144933
34MP0000383_abnormal_hair_follicle1.79321944
35MP0005646_abnormal_pituitary_gland1.78495908
36MP0008057_abnormal_DNA_replication1.75064870
37MP0004381_abnormal_hair_follicle1.68222783
38MP0004782_abnormal_surfactant_physiolog1.66942086
39MP0009745_abnormal_behavioral_response1.65243101
40MP0001501_abnormal_sleep_pattern1.63047550
41MP0003880_abnormal_central_pattern1.57666261
42MP0004484_altered_response_of1.51678551
43MP0002168_other_aberrant_phenotype1.51339350
44MP0008004_abnormal_stomach_pH1.51213365
45MP0001968_abnormal_touch/_nociception1.46998717
46MP0002734_abnormal_mechanical_nocicepti1.46838255
47MP0000579_abnormal_nail_morphology1.46545407
48MP0003122_maternal_imprinting1.41817803
49MP0009780_abnormal_chondrocyte_physiolo1.41707556
50MP0002638_abnormal_pupillary_reflex1.40355478
51MP0002557_abnormal_social/conspecific_i1.39899895
52MP0000566_synostosis1.39222734
53MP0010678_abnormal_skin_adnexa1.38757536
54MP0003635_abnormal_synaptic_transmissio1.38198029
55MP0000026_abnormal_inner_ear1.37429128
56MP0002233_abnormal_nose_morphology1.37403066
57MP0005551_abnormal_eye_electrophysiolog1.37095888
58MP0001929_abnormal_gametogenesis1.36525402
59MP0005645_abnormal_hypothalamus_physiol1.31706725
60MP0002064_seizures1.31169317
61MP0002067_abnormal_sensory_capabilities1.28177681
62MP0010386_abnormal_urinary_bladder1.26699372
63MP0003938_abnormal_ear_development1.25913708
64MP0005451_abnormal_body_composition1.24948607
65MP0002572_abnormal_emotion/affect_behav1.22990088
66MP0000778_abnormal_nervous_system1.22244512
67MP0002928_abnormal_bile_duct1.21683819
68MP0002272_abnormal_nervous_system1.20417742
69MP0002160_abnormal_reproductive_system1.20122634
70MP0001963_abnormal_hearing_physiology1.19575665
71MP0005253_abnormal_eye_physiology1.17734889
72MP0004859_abnormal_synaptic_plasticity1.17128197
73MP0000372_irregular_coat_pigmentation1.14900862
74MP0002282_abnormal_trachea_morphology1.12600900
75MP0001324_abnormal_eye_pigmentation1.12354300
76MP0003283_abnormal_digestive_organ1.11651330
77MP0001293_anophthalmia1.11553810
78MP0004270_analgesia1.10813151
79MP0008995_early_reproductive_senescence1.08279275
80MP0003937_abnormal_limbs/digits/tail_de1.05023215
81MP0001765_abnormal_ion_homeostasis1.04197869
82MP0002210_abnormal_sex_determination1.03981750
83MP0002876_abnormal_thyroid_physiology1.03054478
84MP0001905_abnormal_dopamine_level1.01944387
85MP0002184_abnormal_innervation1.00558504
86MP0002735_abnormal_chemical_nociception1.00228905
87MP0003121_genomic_imprinting0.99782856
88MP0006292_abnormal_olfactory_placode0.99744516
89MP0001502_abnormal_circadian_rhythm0.99370335
90MP0005647_abnormal_sex_gland0.99317140
91MP0003646_muscle_fatigue0.97963818
92MP0003656_abnormal_erythrocyte_physiolo0.95429076
93MP0003941_abnormal_skin_development0.95354051
94MP0001177_atelectasis0.93766682
95MP0005503_abnormal_tendon_morphology0.93287481
96MP0002752_abnormal_somatic_nervous0.91832190
97MP0002161_abnormal_fertility/fecundity0.91602972
98MP0002063_abnormal_learning/memory/cond0.91559455
99MP0005167_abnormal_blood-brain_barrier0.90471996
100MP0005365_abnormal_bile_salt0.90002299
101MP0005395_other_phenotype0.89740984
102MP0000678_abnormal_parathyroid_gland0.89553317
103MP0002249_abnormal_larynx_morphology0.89531678
104MP0002909_abnormal_adrenal_gland0.89092145
105MP0005409_darkened_coat_color0.86803996
106MP0009697_abnormal_copulation0.85684365
107MP0009703_decreased_birth_body0.83102675
108MP0005171_absent_coat_pigmentation0.82333663
109MP0002133_abnormal_respiratory_system0.81735395
110MP0005388_respiratory_system_phenotype0.81735395
111MP0006276_abnormal_autonomic_nervous0.81374011
112MP0002822_catalepsy0.81209832
113MP0003861_abnormal_nervous_system0.81170327
114MP0001485_abnormal_pinna_reflex0.80436179
115MP0001346_abnormal_lacrimal_gland0.79993981
116MP0001970_abnormal_pain_threshold0.79678215
117MP0003724_increased_susceptibility_to0.77777054
118MP0005408_hypopigmentation0.77442005
119MP0008961_abnormal_basal_metabolism0.76910597
120MP0000920_abnormal_myelination0.75695071
121MP0000955_abnormal_spinal_cord0.75595671
122MP0005165_increased_susceptibility_to0.75507432
123MP0001145_abnormal_male_reproductive0.75362331
124MP0003690_abnormal_glial_cell0.75335538
125MP0000049_abnormal_middle_ear0.75081203
126MP0000462_abnormal_digestive_system0.74611732
127MP0002116_abnormal_craniofacial_bone0.74051690
128MP0002108_abnormal_muscle_morphology0.73697579
129MP0005423_abnormal_somatic_nervous0.73255473
130MP0003634_abnormal_glial_cell0.72700966
131MP0005636_abnormal_mineral_homeostasis0.71452284
132MP0005195_abnormal_posterior_eye0.70125483
133MP0003942_abnormal_urinary_system0.69834411
134MP0002066_abnormal_motor_capabilities/c0.69615344
135MP0002882_abnormal_neuron_morphology0.69422781
136MP0005389_reproductive_system_phenotype0.68602137
137MP0009379_abnormal_foot_pigmentation0.67883335
138MP0001958_emphysema0.67343810
139MP0000653_abnormal_sex_gland0.66990634
140MP0009765_abnormal_xenobiotic_induced0.66741187
141MP0009764_decreased_sensitivity_to0.65849891
142MP0008872_abnormal_physiological_respon0.65346189
143MP0005391_vision/eye_phenotype0.64245367
144MP0005083_abnormal_biliary_tract0.62422810
145MP0004883_abnormal_blood_vessel0.61641989
146MP0003890_abnormal_embryonic-extraembry0.60985661
147MP0000631_abnormal_neuroendocrine_gland0.60143569
148MP0002938_white_spotting0.58860841
149MP0001299_abnormal_eye_distance/0.58197769
150MP0005248_abnormal_Harderian_gland0.57809933
151MP0005187_abnormal_penis_morphology0.57477381
152MP0002229_neurodegeneration0.56821176
153MP0002084_abnormal_developmental_patter0.53308355
154MP0002152_abnormal_brain_morphology0.53286633

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)8.39483093
2Abnormal respiratory epithelium morphology (HP:0012253)8.11852500
3Abnormal respiratory motile cilium morphology (HP:0005938)8.11852500
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.01336726
5Absent/shortened dynein arms (HP:0200106)8.01336726
6Split foot (HP:0001839)5.82337105
7Oligodactyly (hands) (HP:0001180)5.60545294
8Chronic bronchitis (HP:0004469)5.29752982
9Severe visual impairment (HP:0001141)4.71388490
10Bronchiectasis (HP:0002110)4.54249054
11Oligodactyly (HP:0012165)3.74183677
12Absent hand (HP:0004050)3.67114301
13Recurrent sinusitis (HP:0011108)3.57113812
14Abnormality of macular pigmentation (HP:0008002)3.40873393
15Nasal polyposis (HP:0100582)3.32489986
16Tubulointerstitial nephritis (HP:0001970)3.32211921
17Pancreatic fibrosis (HP:0100732)3.18489448
18Abdominal situs inversus (HP:0003363)3.15637597
19Abnormality of abdominal situs (HP:0011620)3.15637597
20True hermaphroditism (HP:0010459)2.97706965
21Median cleft lip (HP:0000161)2.94579867
22Pendular nystagmus (HP:0012043)2.91838519
23Chronic otitis media (HP:0000389)2.91310287
24Nephronophthisis (HP:0000090)2.80331031
25Facial cleft (HP:0002006)2.76758289
26Postaxial foot polydactyly (HP:0001830)2.73395199
27Medial flaring of the eyebrow (HP:0010747)2.69863769
28Polydipsia (HP:0001959)2.67407776
29Abnormal drinking behavior (HP:0030082)2.67407776
30Abnormality of the nasal mucosa (HP:0000433)2.65501558
31Abnormal biliary tract physiology (HP:0012439)2.56507256
32Bile duct proliferation (HP:0001408)2.56507256
33Bronchitis (HP:0012387)2.53676515
34Increased circulating renin level (HP:0000848)2.52245957
35Congenital hepatic fibrosis (HP:0002612)2.47315951
36Gait imbalance (HP:0002141)2.47133498
37Infertility (HP:0000789)2.47069407
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41757772
39Congenital primary aphakia (HP:0007707)2.41575377
40Chronic hepatic failure (HP:0100626)2.36549263
41Severe Myopia (HP:0011003)2.31870648
42Stage 5 chronic kidney disease (HP:0003774)2.30254999
43Molar tooth sign on MRI (HP:0002419)2.28893044
44Abnormality of midbrain morphology (HP:0002418)2.28893044
45Occipital encephalocele (HP:0002085)2.27120388
46Chronic sinusitis (HP:0011109)2.21377828
47Agitation (HP:0000713)2.21137055
48Hypomagnesemia (HP:0002917)2.19399184
49Nephrogenic diabetes insipidus (HP:0009806)2.12763343
50Abnormality of the renal medulla (HP:0100957)2.11718553
51Preaxial hand polydactyly (HP:0001177)2.10443194
52Pancreatic cysts (HP:0001737)2.08302459
53Alveolar cell carcinoma (HP:0006519)2.08191420
54Furrowed tongue (HP:0000221)2.07195156
55Short nail (HP:0001799)2.06561663
56Genital tract atresia (HP:0001827)2.04908171
57Recurrent otitis media (HP:0000403)2.04393853
58Tubulointerstitial abnormality (HP:0001969)2.01388368
59Oculomotor apraxia (HP:0000657)2.01256227
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.2665825
61Abnormal respiratory motile cilium physiology (HP:0012261)10.3556476
62Abnormal ciliary motility (HP:0012262)10.1361512
63Bell-shaped thorax (HP:0001591)1.97249036
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94897629
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.94897629
66Hyperactive renin-angiotensin system (HP:0000841)1.92968257
67Male pseudohermaphroditism (HP:0000037)1.92083338
68Vaginal atresia (HP:0000148)1.91080298
69Neoplasm of the tracheobronchial system (HP:0100552)1.91029985
70Tubular atrophy (HP:0000092)1.86595124
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.86286439
72Supernumerary spleens (HP:0009799)1.86212560
73Neonatal short-limb short stature (HP:0008921)1.85217470
74Abnormality of dentin (HP:0010299)1.84424423
75Recurrent bronchitis (HP:0002837)1.80952049
76Postaxial hand polydactyly (HP:0001162)1.80194717
77Abnormal ventriculo-arterial connection (HP:0011563)1.80010631
78Transposition of the great arteries (HP:0001669)1.80010631
79Abnormal connection of the cardiac segments (HP:0011545)1.80010631
80Tetany (HP:0001281)1.71309580
81Polyuria (HP:0000103)1.67976715
82Horizontal nystagmus (HP:0000666)1.65538608
83Intellectual disability, moderate (HP:0002342)1.64936335
84Cystic liver disease (HP:0006706)1.64769791
85Poor coordination (HP:0002370)1.63090018
86Abnormality of magnesium homeostasis (HP:0004921)1.60161961
87Abnormality of the dental root (HP:0006486)1.59856676
88Taurodontia (HP:0000679)1.59856676
89Abnormality of permanent molar morphology (HP:0011071)1.59856676
90Nephropathy (HP:0000112)1.59839135
91Tachypnea (HP:0002789)1.59627085
92Abnormality of molar (HP:0011077)1.56669238
93Abnormality of molar morphology (HP:0011070)1.56669238
94Ectopic anus (HP:0004397)1.55244769
95Abnormal urine output (HP:0012590)1.54390974
96Retinitis pigmentosa (HP:0000510)1.52157934
97Abnormality of renal excretion (HP:0011036)1.50401570
98Male infertility (HP:0003251)1.49621571
99Anencephaly (HP:0002323)1.49365384
100Atelectasis (HP:0100750)1.49338546
101Sclerocornea (HP:0000647)1.47999553
102Hyperphosphatemia (HP:0002905)1.47508635
103Fibular hypoplasia (HP:0003038)1.47429801
104Parakeratosis (HP:0001036)1.46925911
105Abnormality of renin-angiotensin system (HP:0000847)1.46780798
106Aplasia/Hypoplasia of the lens (HP:0008063)1.46153506
107Abnormality of the dental pulp (HP:0006479)1.44630391
108Absent frontal sinuses (HP:0002688)1.41645632
109Asplenia (HP:0001746)1.40336694
110Abnormality of the renal cortex (HP:0011035)1.40284373
111Narrow forehead (HP:0000341)1.40090841
112Tubulointerstitial fibrosis (HP:0005576)1.36507436
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.35914798
114Broad distal phalanx of finger (HP:0009836)1.35748831
115Decreased circulating renin level (HP:0003351)1.26787720
116Prominent nasal bridge (HP:0000426)1.19610248
117Optic nerve coloboma (HP:0000588)1.12762497
118Hyperkalemia (HP:0002153)1.12614498
119Renal salt wasting (HP:0000127)1.12188150
120Highly arched eyebrow (HP:0002553)1.09733479
121Aganglionic megacolon (HP:0002251)1.08378467
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.08137453
123Bifid scrotum (HP:0000048)1.05719368
124Multicystic kidney dysplasia (HP:0000003)1.02876761
125Nonprogressive disorder (HP:0003680)1.01094775
126Absent speech (HP:0001344)0.99105555
127Absent rod-and cone-mediated responses on ERG (HP:0007688)0.98723092
128Cone-rod dystrophy (HP:0000548)0.97888512
129Hypoplastic labia majora (HP:0000059)0.97418058
130Short thorax (HP:0010306)0.92506594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.64786065
2PNCK5.60647842
3CASK4.42115888
4MST42.79801772
5STK392.61245055
6MKNK22.58686963
7GRK12.55258542
8BLK2.18327481
9TLK12.16281688
10CCNB12.12169922
11MAP3K42.04380793
12MAPKAPK31.99510148
13TNK21.93946207
14EIF2AK21.88805133
15NTRK31.84994150
16PRKCG1.78889013
17MUSK1.67804941
18STK241.62692483
19IRAK31.59904364
20NME11.58640271
21TNIK1.58052236
22WNK31.48596787
23PRKD31.46952896
24MARK11.39181420
25OXSR11.36822202
26MAP3K141.31566481
27WNK41.29398312
28FGFR21.25451905
29CDK31.22445175
30IRAK11.21152793
31MAP4K21.18979080
32PKN11.18269571
33SGK2231.17163650
34SGK4941.17163650
35NTRK21.16334708
36PRKCE1.16287958
37MKNK11.15519674
38NEK61.12085786
39DYRK1B1.11878460
40ERBB31.11040955
41PTK2B1.10703466
42BCR1.10494048
43SGK21.09103266
44VRK11.06918950
45PINK11.05528465
46EPHB11.04730673
47TTK1.04554211
48CAMK2A1.04246885
49MAP3K121.03649703
50FES1.02567183
51MAP2K41.01081444
52CSK0.99048658
53PDK30.99006470
54PDK40.99006470
55EPHA20.98699399
56TRPM70.97733879
57AKT30.94242023
58EPHA40.94093451
59PASK0.93851117
60WNK10.90388793
61MAP2K70.88185372
62MAP3K30.84458989
63MAPK130.82928407
64MAPKAPK50.82363852
65STK110.80292171
66DYRK30.79578458
67DAPK20.77243815
68MAP3K20.76558058
69LRRK20.76477951
70CAMK2G0.75571226
71CAMK2B0.75218294
72PRKCQ0.74771564
73MAP2K20.74275002
74BRSK20.73393159
75MAP3K70.71301561
76INSRR0.70601639
77STK100.69435730
78GSK3A0.69144036
79MAP3K60.68262449
80ROCK20.66983558
81BMPR1B0.66110757
82CAMK10.64741077
83AKT20.64696670
84PAK20.64246769
85NEK90.64020425
86DYRK20.62563223
87UHMK10.62509722
88BMPR20.60342202
89SIK10.59195750
90PRKG10.58461603
91GRK60.57441035
92MARK20.56915014
93CSNK1G10.55730379
94MST1R0.54282553
95CSNK1G20.53756696
96PRKCH0.53103681
97CAMK1G0.52914268
98PRKACA0.52696457
99PAK30.51960923
100GRK50.51710061
101RPS6KL10.51636652
102RPS6KC10.51636652
103SGK30.51492709
104FGR0.51311396
105PRPF4B0.51016909
106PRKCI0.50693640
107CAMK40.50319793
108PRKCZ0.48424489
109RPS6KA20.47925803
110MET0.47766445
111ERBB20.46500805
112STK160.46256953
113BMX0.44872510
114CDK50.44591265
115ITK0.44030474
116CDK80.43573728
117ERBB40.43099560
118AURKA0.42867773
119STK380.42750395
120PIM20.42143871
121WEE10.41973548
122SIK20.41628258
123PDK20.40769644
124EEF2K0.40472438
125CAMKK10.39956687
126ADRBK20.39692749
127EPHA30.39685565
128NLK0.39323078
129DYRK1A0.38841340
130ADRBK10.38646066
131RPS6KA60.35306401
132STK38L0.35277045
133NTRK10.34806011
134RPS6KA50.34792783
135PRKAA20.34515658
136SRC0.34263480
137LMTK20.32931170
138PRKCB0.32781390
139SGK10.32716927
140PRKCA0.32452316
141LATS10.31818798
142ICK0.31495694
143CAMK2D0.31428861
144PRKCD0.30933022
145DMPK0.29925659
146FRK0.29830177
147RET0.29430276
148EPHB20.29296786
149TAOK10.27873944
150ABL10.26291622
151MINK10.24509589
152CDK90.22944845
153ROCK10.20645333
154RPS6KA30.19140878
155MAP2K10.18796142

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.66505013
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.16705480
3Tyrosine metabolism_Homo sapiens_hsa003502.91752560
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85576410
5Hedgehog signaling pathway_Homo sapiens_hsa043402.84828435
6Basal cell carcinoma_Homo sapiens_hsa052172.58172290
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.51281582
8Nicotine addiction_Homo sapiens_hsa050332.34621800
9Vitamin B6 metabolism_Homo sapiens_hsa007502.29964366
10Histidine metabolism_Homo sapiens_hsa003402.24943147
11Insulin secretion_Homo sapiens_hsa049112.08059867
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87742393
13Ether lipid metabolism_Homo sapiens_hsa005651.84532195
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82888595
15Morphine addiction_Homo sapiens_hsa050321.81534869
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70414255
17Propanoate metabolism_Homo sapiens_hsa006401.68800081
18Dorso-ventral axis formation_Homo sapiens_hsa043201.64359198
19Fatty acid biosynthesis_Homo sapiens_hsa000611.63084168
20Linoleic acid metabolism_Homo sapiens_hsa005911.62481344
21Huntingtons disease_Homo sapiens_hsa050161.61976204
22Calcium signaling pathway_Homo sapiens_hsa040201.61557389
23Parkinsons disease_Homo sapiens_hsa050121.61281506
24Arginine and proline metabolism_Homo sapiens_hsa003301.58401743
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.57216444
26Caffeine metabolism_Homo sapiens_hsa002321.57161619
27Ovarian steroidogenesis_Homo sapiens_hsa049131.57016508
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55251046
29Glutamatergic synapse_Homo sapiens_hsa047241.52725520
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.48831568
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45807218
32Nitrogen metabolism_Homo sapiens_hsa009101.42581397
33Melanogenesis_Homo sapiens_hsa049161.40216765
34Circadian entrainment_Homo sapiens_hsa047131.36465078
35Taste transduction_Homo sapiens_hsa047421.35915362
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.33319905
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30761768
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30386951
39Arachidonic acid metabolism_Homo sapiens_hsa005901.25098919
40Steroid biosynthesis_Homo sapiens_hsa001001.24848768
41beta-Alanine metabolism_Homo sapiens_hsa004101.23698787
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21910360
43Phototransduction_Homo sapiens_hsa047441.21553741
44GABAergic synapse_Homo sapiens_hsa047271.20443680
45cAMP signaling pathway_Homo sapiens_hsa040241.20316296
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18578815
47Hippo signaling pathway_Homo sapiens_hsa043901.14066426
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13558562
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11816913
50Wnt signaling pathway_Homo sapiens_hsa043101.11362572
51Axon guidance_Homo sapiens_hsa043601.07549077
52Butanoate metabolism_Homo sapiens_hsa006501.07317965
53Serotonergic synapse_Homo sapiens_hsa047261.06732047
54Tryptophan metabolism_Homo sapiens_hsa003801.04566538
55Long-term depression_Homo sapiens_hsa047301.02254546
56Salivary secretion_Homo sapiens_hsa049700.99248058
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95734640
58Retinol metabolism_Homo sapiens_hsa008300.95303810
59Collecting duct acid secretion_Homo sapiens_hsa049660.93683983
60Fatty acid elongation_Homo sapiens_hsa000620.93277301
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92658171
62Amphetamine addiction_Homo sapiens_hsa050310.92273226
63PPAR signaling pathway_Homo sapiens_hsa033200.91973205
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86570105
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85920958
66Glycerolipid metabolism_Homo sapiens_hsa005610.85345199
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.84030491
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83693996
69Renin secretion_Homo sapiens_hsa049240.82922285
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80666372
71Notch signaling pathway_Homo sapiens_hsa043300.80377208
72Mineral absorption_Homo sapiens_hsa049780.80246276
73Purine metabolism_Homo sapiens_hsa002300.77745802
74Cholinergic synapse_Homo sapiens_hsa047250.77351120
75Sphingolipid metabolism_Homo sapiens_hsa006000.75447615
76Gastric acid secretion_Homo sapiens_hsa049710.73988394
77Pyruvate metabolism_Homo sapiens_hsa006200.73099216
78Cocaine addiction_Homo sapiens_hsa050300.72202434
79Cardiac muscle contraction_Homo sapiens_hsa042600.70608615
80ABC transporters_Homo sapiens_hsa020100.70510426
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.68795457
82Estrogen signaling pathway_Homo sapiens_hsa049150.67910375
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65715609
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64749945
85Oxidative phosphorylation_Homo sapiens_hsa001900.64370018
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63094987
87Starch and sucrose metabolism_Homo sapiens_hsa005000.62109663
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61841277
89Long-term potentiation_Homo sapiens_hsa047200.61320189
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59812390
91Phagosome_Homo sapiens_hsa041450.59228908
92Olfactory transduction_Homo sapiens_hsa047400.59010728
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57853551
94Tight junction_Homo sapiens_hsa045300.56925353
95Alcoholism_Homo sapiens_hsa050340.56856702
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55942833
97Fatty acid degradation_Homo sapiens_hsa000710.55337556
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55174182
99Systemic lupus erythematosus_Homo sapiens_hsa053220.53108174
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52319200
101Alzheimers disease_Homo sapiens_hsa050100.50415428
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47502499
103Arginine biosynthesis_Homo sapiens_hsa002200.46544477
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45413667
105Inositol phosphate metabolism_Homo sapiens_hsa005620.44509982
106Peroxisome_Homo sapiens_hsa041460.44246815
107Rheumatoid arthritis_Homo sapiens_hsa053230.44214802
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43494447
109Protein digestion and absorption_Homo sapiens_hsa049740.43215815
110ECM-receptor interaction_Homo sapiens_hsa045120.41391156
111Synaptic vesicle cycle_Homo sapiens_hsa047210.40611955
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40505554
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39766992
114Autoimmune thyroid disease_Homo sapiens_hsa053200.38813401
115Glutathione metabolism_Homo sapiens_hsa004800.38727268
116Metabolic pathways_Homo sapiens_hsa011000.38253027
117Pancreatic secretion_Homo sapiens_hsa049720.37069490
118Dilated cardiomyopathy_Homo sapiens_hsa054140.36261879
119Circadian rhythm_Homo sapiens_hsa047100.35549649
120Ras signaling pathway_Homo sapiens_hsa040140.35252040
121Chemical carcinogenesis_Homo sapiens_hsa052040.34325308
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34048198
123Ribosome_Homo sapiens_hsa030100.33969591
124Vitamin digestion and absorption_Homo sapiens_hsa049770.29419045
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28301249
126Dopaminergic synapse_Homo sapiens_hsa047280.23981838
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23066687
128Gap junction_Homo sapiens_hsa045400.22897526
129Nucleotide excision repair_Homo sapiens_hsa034200.22851540
130Choline metabolism in cancer_Homo sapiens_hsa052310.22080444
131Complement and coagulation cascades_Homo sapiens_hsa046100.20120508
132N-Glycan biosynthesis_Homo sapiens_hsa005100.19473306
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.19260650
134Bile secretion_Homo sapiens_hsa049760.17569372
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.17012539

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