ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.36977610
2	male meiosis (GO:0007140)	7.23431831
3	regulation of phosphoprotein phosphatase activity (GO:0043666)	6.62702216
4	positive regulation of catecholamine secretion (GO:0033605)	6.58643764
5	spermatid development (GO:0007286)	6.15483345
6	synapsis (GO:0007129)	5.86403414
7	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	5.69941942
8	acrosome reaction (GO:0007340)	5.49603433
9	multicellular organism reproduction (GO:0032504)	5.47504606
10	regulation of oxidative phosphorylation (GO:0002082)	5.34628436
11	regulation of oxidative stress-induced neuron death (GO:1903203)	5.02891742
12	sperm motility (GO:0030317)	4.96105548
13	binding of sperm to zona pellucida (GO:0007339)	4.84865662
14	somite rostral/caudal axis specification (GO:0032525)	4.55292428
15	histone exchange (GO:0043486)	4.53274887
16	motile cilium assembly (GO:0044458)	4.52753919
17	chromosome organization involved in meiosis (GO:0070192)	4.43731062
18	indole-containing compound catabolic process (GO:0042436)	4.36256324
19	indolalkylamine catabolic process (GO:0046218)	4.36256324
20	tryptophan catabolic process (GO:0006569)	4.36256324
21	sperm-egg recognition (GO:0035036)	4.29359353
22	paraxial mesoderm development (GO:0048339)	4.28836692
23	Leydig cell differentiation (GO:0033327)	4.20155735
24	axonemal dynein complex assembly (GO:0070286)	4.15429739
25	relaxation of smooth muscle (GO:0044557)	3.98231427
26	regulation of cellular respiration (GO:0043457)	3.96768067
27	activation of protein kinase B activity (GO:0032148)	3.94664380
28	epithelial cilium movement (GO:0003351)	3.91223660
29	germ cell development (GO:0007281)	3.89549286
30	meiotic nuclear division (GO:0007126)	3.88125956
31	nodal signaling pathway (GO:0038092)	3.85475468
32	male sex determination (GO:0030238)	3.69394401
33	synaptonemal complex assembly (GO:0007130)	3.67006062
34	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.62075069
35	piRNA metabolic process (GO:0034587)	3.58874317
36	cilium or flagellum-dependent cell motility (GO:0001539)	3.58757280
37	single fertilization (GO:0007338)	3.55863211
38	cell-cell recognition (GO:0009988)	3.55311572
39	potassium ion export (GO:0071435)	3.47446530
40	DNA double-strand break processing (GO:0000729)	3.42567362
41	nucleosome disassembly (GO:0006337)	3.39627609
42	protein-DNA complex disassembly (GO:0032986)	3.39627609
43	synaptonemal complex organization (GO:0070193)	3.33662774
44	organic cation transport (GO:0015695)	3.31293276
45	tryptophan metabolic process (GO:0006568)	3.31190256
46	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.28222796
47	glycogen metabolic process (GO:0005977)	3.25843615
48	reproduction (GO:0000003)	3.25405368
49	androgen biosynthetic process (GO:0006702)	3.24173586
50	regulation of glucocorticoid metabolic process (GO:0031943)	3.23609363
51	polyamine biosynthetic process (GO:0006596)	3.22076351
52	glucan metabolic process (GO:0044042)	3.19931246
53	cellular glucan metabolic process (GO:0006073)	3.19931246
54	DNA replication checkpoint (GO:0000076)	3.18574618
55	embryonic axis specification (GO:0000578)	3.15676495
56	embryonic foregut morphogenesis (GO:0048617)	3.15518827
57	regulation of meiosis I (GO:0060631)	3.14733433
58	genitalia morphogenesis (GO:0035112)	3.14621001
59	positive regulation of glycolytic process (GO:0045821)	3.14133909
60	positive regulation of meiotic cell cycle (GO:0051446)	3.13425850
61	DNA methylation involved in gamete generation (GO:0043046)	3.10126709
62	regulation of autophagic vacuole assembly (GO:2000785)	3.04863491
63	TOR signaling (GO:0031929)	3.02433511
64	ventricular system development (GO:0021591)	3.01389660
65	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.99801298
66	cilium movement (GO:0003341)	2.99012375
67	acrosome assembly (GO:0001675)	2.98195043
68	male meiosis I (GO:0007141)	2.96505202
69	negative regulation of response to reactive oxygen species (GO:1901032)	2.96014572
70	protein neddylation (GO:0045116)	2.93690699
71	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.93104214
72	keratinocyte development (GO:0003334)	2.88776417
73	aspartate family amino acid catabolic process (GO:0009068)	2.88333180
74	glutamine family amino acid catabolic process (GO:0009065)	2.84436936
75	oogenesis (GO:0048477)	2.80631528
76	regulation of dopamine secretion (GO:0014059)	2.80106068
77	heterochromatin organization (GO:0070828)	2.78441698
78	regulation of cardiac muscle cell apoptotic process (GO:0010665)	2.78279154
79	regulation of phosphatase activity (GO:0010921)	2.76299010
80	positive regulation of meiosis (GO:0045836)	2.75990997
81	DNA synthesis involved in DNA repair (GO:0000731)	2.75165104
82	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.73069255
83	regulation of acrosome reaction (GO:0060046)	2.69885829
84	heme transport (GO:0015886)	2.68742235
85	membrane repolarization during action potential (GO:0086011)	2.67005175
86	fertilization (GO:0009566)	2.65885450
87	negative regulation of keratinocyte proliferation (GO:0010839)	2.63927787
88	embryonic heart tube development (GO:0035050)	2.60117826
89	calcium ion-dependent exocytosis (GO:0017156)	2.59236109
90	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.55731577
91	ectoderm development (GO:0007398)	2.55328164
92	regulation of keratinocyte proliferation (GO:0010837)	2.55201513
93	indolalkylamine metabolic process (GO:0006586)	2.54362344
94	cellular response to toxic substance (GO:0097237)	2.54177494
95	mitochondrion degradation (GO:0000422)	2.52810320
96	cGMP-mediated signaling (GO:0019934)	2.49781181
97	rRNA methylation (GO:0031167)	2.49774427
98	sex determination (GO:0007530)	2.49735898
99	positive regulation of amine transport (GO:0051954)	2.49061064
100	anterior/posterior axis specification, embryo (GO:0008595)	2.46767456

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	9.43706611
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.74879591
3	FUS_26573619_Chip-Seq_HEK293_Human	3.33645068
4	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.04290031
5	AR_21909140_ChIP-Seq_LNCAP_Human	2.62627221
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.61637013
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52353695
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41766046
9	EWS_26573619_Chip-Seq_HEK293_Human	2.20774904
10	GATA1_22025678_ChIP-Seq_K562_Human	2.16855697
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.14624688
12	VDR_22108803_ChIP-Seq_LS180_Human	2.13138652
13	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.03732863
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03732096
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02714693
16	P300_19829295_ChIP-Seq_ESCs_Human	2.00092658
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.95271437
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.91355708
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.87384126
20	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.85883330
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81594391
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81275159
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81275159
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76497885
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.76068001
26	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.75529376
27	BCAT_22108803_ChIP-Seq_LS180_Human	1.69510572
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.65694653
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65694653
30	AHR_22903824_ChIP-Seq_MCF-7_Human	1.64391273
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64387629
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.58984758
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.56697704
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55762794
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.54472014
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52427222
37	RUNX2_22187159_ChIP-Seq_PCA_Human	1.52252518
38	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.50756289
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44266723
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.43062557
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.41218134
42	RXR_22108803_ChIP-Seq_LS180_Human	1.41006580
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40548586
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37292000
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36860043
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35380949
47	AR_25329375_ChIP-Seq_VCAP_Human	1.34211988
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32108046
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30644456
50	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.30318570
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26987402
52	TBL1_22424771_ChIP-Seq_293T_Human	1.26881420
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26611047
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26611047
55	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.25370817
56	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25166711
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.22455869
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.21494523
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17114976
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.16887813
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.15550801
62	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.15281697
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14962859
64	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.13880467
65	ERA_21632823_ChIP-Seq_H3396_Human	1.13496984
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13120071
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12645162
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11628058
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11604646
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10700952
71	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10052834
72	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07291709
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.06328472
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.06014458
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05737689
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.05681829
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02683344
78	ELF5_23300383_ChIP-Seq_T47D_Human	1.02508522
79	RAC3_21632823_ChIP-Seq_H3396_Human	1.02491684
80	STAT3_23295773_ChIP-Seq_U87_Human	1.01832334
81	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01398618
82	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.98679361
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98369841
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.98203299
85	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.96687855
86	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95609707
87	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94842659
88	OCT4_20526341_ChIP-Seq_ESCs_Human	0.94358956
89	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.92482939
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92178746
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.91614375
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91392189
93	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.90614466
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90428540
95	AR_20517297_ChIP-Seq_VCAP_Human	0.89831574
96	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.86133831
97	NFYB_21822215_ChIP-Seq_K562_Human	0.85591481
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.84988843
99	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.82885021
100	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.81741991

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003315_abnormal_perineum_morphology	5.38376239
2	MP0005410_abnormal_fertilization	5.20310399
3	MP0002160_abnormal_reproductive_system	3.63744269
4	MP0008004_abnormal_stomach_pH	3.47664810
5	MP0003890_abnormal_embryonic-extraembry	3.17409477
6	MP0005187_abnormal_penis_morphology	3.16108050
7	MP0003136_yellow_coat_color	3.11216378
8	MP0000537_abnormal_urethra_morphology	2.42452231
9	MP0005499_abnormal_olfactory_system	2.24422443
10	MP0005394_taste/olfaction_phenotype	2.24422443
11	MP0003698_abnormal_male_reproductive	2.20983293
12	MP0001929_abnormal_gametogenesis	2.20955220
13	MP0008877_abnormal_DNA_methylation	2.17858460
14	MP0001188_hyperpigmentation	2.04667527
15	MP0003718_maternal_effect	1.96841326
16	MP0002282_abnormal_trachea_morphology	1.85736898
17	MP0005646_abnormal_pituitary_gland	1.84491669
18	MP0002210_abnormal_sex_determination	1.81545948
19	MP0002163_abnormal_gland_morphology	1.76421331
20	MP0008995_early_reproductive_senescence	1.75996740
21	MP0008058_abnormal_DNA_repair	1.75146268
22	MP0005389_reproductive_system_phenotype	1.73926833
23	MP0002249_abnormal_larynx_morphology	1.70909368
24	MP0001984_abnormal_olfaction	1.65734512
25	MP0009697_abnormal_copulation	1.63469647
26	MP0000538_abnormal_urinary_bladder	1.60509216
27	MP0005647_abnormal_sex_gland	1.59834189
28	MP0001145_abnormal_male_reproductive	1.58871104
29	MP0000631_abnormal_neuroendocrine_gland	1.53650714
30	MP0005623_abnormal_meninges_morphology	1.49903232
31	MP0005360_urolithiasis	1.48812084
32	MP0001346_abnormal_lacrimal_gland	1.48508263
33	MP0003937_abnormal_limbs/digits/tail_de	1.46880208
34	MP0009250_abnormal_appendicular_skeleto	1.46564373
35	MP0010030_abnormal_orbit_morphology	1.44227843
36	MP0000653_abnormal_sex_gland	1.44001226
37	MP0006072_abnormal_retinal_apoptosis	1.38451156
38	MP0000049_abnormal_middle_ear	1.37841135
39	MP0008789_abnormal_olfactory_epithelium	1.35602699
40	MP0005174_abnormal_tail_pigmentation	1.34691084
41	MP0006292_abnormal_olfactory_placode	1.28432093
42	MP0002161_abnormal_fertility/fecundity	1.24484250
43	MP0003693_abnormal_embryo_hatching	1.22073713
44	MP0002233_abnormal_nose_morphology	1.21440506
45	MP0001664_abnormal_digestion	1.20535369
46	MP0002127_abnormal_cardiovascular_syste	1.16954337
47	MP0003119_abnormal_digestive_system	1.15917943
48	MP0010386_abnormal_urinary_bladder	1.14599934
49	MP0004272_abnormal_basement_membrane	1.13075445
50	MP0009053_abnormal_anal_canal	1.11505121
51	MP0005379_endocrine/exocrine_gland_phen	1.08968073
52	MP0003936_abnormal_reproductive_system	1.06855312
53	MP0002234_abnormal_pharynx_morphology	1.06239169
54	MP0005395_other_phenotype	1.05991084
55	MP0008057_abnormal_DNA_replication	1.03075256
56	MP0003045_fibrosis	1.02335894
57	MP0004215_abnormal_myocardial_fiber	1.00980014
58	MP0002090_abnormal_vision	1.00759975
59	MP0003195_calcinosis	1.00083534
60	MP0010368_abnormal_lymphatic_system	0.98922559
61	MP0004133_heterotaxia	0.97350601
62	MP0006036_abnormal_mitochondrial_physio	0.94391727
63	MP0005058_abnormal_lysosome_morphology	0.93560451
64	MP0003385_abnormal_body_wall	0.91392846
65	MP0002877_abnormal_melanocyte_morpholog	0.87760077
66	MP0002876_abnormal_thyroid_physiology	0.87507283
67	MP0010094_abnormal_chromosome_stability	0.87273145
68	MP0005409_darkened_coat_color	0.85299749
69	MP0003935_abnormal_craniofacial_develop	0.84860737
70	MP0001968_abnormal_touch/_nociception	0.83852553
71	MP0001919_abnormal_reproductive_system	0.83201254
72	MP0004782_abnormal_surfactant_physiolog	0.81641984
73	MP0001485_abnormal_pinna_reflex	0.79662501
74	MP0004957_abnormal_blastocyst_morpholog	0.79496966
75	MP0002084_abnormal_developmental_patter	0.78226649
76	MP0003755_abnormal_palate_morphology	0.77104684
77	MP0000470_abnormal_stomach_morphology	0.76687947
78	MP0001286_abnormal_eye_development	0.76561959
79	MP0004085_abnormal_heartbeat	0.74801249
80	MP0005551_abnormal_eye_electrophysiolog	0.74018632
81	MP0001502_abnormal_circadian_rhythm	0.73992915
82	MP0001672_abnormal_embryogenesis/_devel	0.73015990
83	MP0005380_embryogenesis_phenotype	0.73015990
84	MP0002736_abnormal_nociception_after	0.72923665
85	MP0005171_absent_coat_pigmentation	0.69608739
86	MP0002697_abnormal_eye_size	0.69173367
87	MP0001905_abnormal_dopamine_level	0.68484962
88	MP0002837_dystrophic_cardiac_calcinosis	0.66986952
89	MP0001764_abnormal_homeostasis	0.66872830
90	MP0005367_renal/urinary_system_phenotyp	0.64615598
91	MP0000516_abnormal_urinary_system	0.64615598
92	MP0005248_abnormal_Harderian_gland	0.64230765
93	MP0001293_anophthalmia	0.62876424
94	MP0002085_abnormal_embryonic_tissue	0.61188298
95	MP0001730_embryonic_growth_arrest	0.60895230
96	MP0000566_synostosis	0.60466410
97	MP0005391_vision/eye_phenotype	0.59946799
98	MP0005253_abnormal_eye_physiology	0.59580854
99	MP0002111_abnormal_tail_morphology	0.59017675
100	MP0000015_abnormal_ear_pigmentation	0.58243487

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal sex determination (HP:0012244)	5.23224536
2	Sex reversal (HP:0012245)	5.23224536
3	Hypoplasia of the uterus (HP:0000013)	4.61046105
4	Reduced antithrombin III activity (HP:0001976)	4.37924268
5	Aplasia/hypoplasia of the uterus (HP:0008684)	4.15824300
6	Male pseudohermaphroditism (HP:0000037)	4.02976170
7	Resting tremor (HP:0002322)	3.90497108
8	Birth length less than 3rd percentile (HP:0003561)	3.77132974
9	Gonadal dysgenesis (HP:0000133)	3.69025172
10	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.48878223
11	Congenital malformation of the right heart (HP:0011723)	3.39590723
12	Double outlet right ventricle (HP:0001719)	3.39590723
13	Facial hemangioma (HP:0000329)	3.27436313
14	Short middle phalanx of the 5th finger (HP:0004220)	3.16384464
15	Chronic hepatic failure (HP:0100626)	3.15036924
16	Abnormal respiratory motile cilium physiology (HP:0012261)	2.94408025
17	Germ cell neoplasia (HP:0100728)	2.80914641
18	Occipital encephalocele (HP:0002085)	2.79218837
19	Protruding tongue (HP:0010808)	2.77333149
20	Esophageal atresia (HP:0002032)	2.76236938
21	Absent/shortened dynein arms (HP:0200106)	2.73547446
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73547446
23	Congenital sensorineural hearing impairment (HP:0008527)	2.71498222
24	Abnormal biliary tract physiology (HP:0012439)	2.66612807
25	Bile duct proliferation (HP:0001408)	2.66612807
26	Abnormal ciliary motility (HP:0012262)	2.65207074
27	Capillary hemangiomas (HP:0005306)	2.61781832
28	Absent radius (HP:0003974)	2.60858595
29	Pancreatic cysts (HP:0001737)	2.59383216
30	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.56090163
31	Gastrointestinal atresia (HP:0002589)	2.55002993
32	Abnormality of the columella (HP:0009929)	2.54503502
33	Aplasia involving forearm bones (HP:0009822)	2.44683666
34	Absent forearm bone (HP:0003953)	2.44683666
35	Abnormality of the intrinsic pathway (HP:0010989)	2.41465137
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.39529297
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.39529297
38	Abnormal protein glycosylation (HP:0012346)	2.39529297
39	Abnormal glycosylation (HP:0012345)	2.39529297
40	Abnormal respiratory motile cilium morphology (HP:0005938)	2.38833819
41	Abnormal respiratory epithelium morphology (HP:0012253)	2.38833819
42	Pancreatic fibrosis (HP:0100732)	2.38688665
43	Premature ovarian failure (HP:0008209)	2.36220505
44	Anencephaly (HP:0002323)	2.32442497
45	Abnormality of the ileum (HP:0001549)	2.32089292
46	Abnormal umbilical cord blood vessels (HP:0011403)	2.31543313
47	Single umbilical artery (HP:0001195)	2.31543313
48	Abnormality of the fetal cardiovascular system (HP:0010948)	2.31543313
49	Molar tooth sign on MRI (HP:0002419)	2.28028696
50	Abnormality of midbrain morphology (HP:0002418)	2.28028696
51	Type II lissencephaly (HP:0007260)	2.27688414
52	Bifid tongue (HP:0010297)	2.24884957
53	Preaxial foot polydactyly (HP:0001841)	2.24416853
54	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.23941924
55	Meckel diverticulum (HP:0002245)	2.21259759
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.17263045
57	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.16457855
58	Cerebellar dysplasia (HP:0007033)	2.15894433
59	True hermaphroditism (HP:0010459)	2.14617087
60	Preauricular pit (HP:0004467)	2.14272539
61	Periauricular skin pits (HP:0100277)	2.14272539
62	Abnormal ventriculo-arterial connection (HP:0011563)	2.12535250
63	Transposition of the great arteries (HP:0001669)	2.12535250
64	Abnormal connection of the cardiac segments (HP:0011545)	2.12535250
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09215747
66	Abnormality of the lumbar spine (HP:0100712)	2.08545647
67	Sensory axonal neuropathy (HP:0003390)	2.07698409
68	Rhinitis (HP:0012384)	2.06841771
69	Aplasia cutis congenita (HP:0001057)	2.02876145
70	Oligodactyly (hands) (HP:0001180)	2.02041674
71	Intestinal atresia (HP:0011100)	2.01470593
72	Volvulus (HP:0002580)	1.99524677
73	Rectal fistula (HP:0100590)	1.98260610
74	Rectovaginal fistula (HP:0000143)	1.98260610
75	Retinal dysplasia (HP:0007973)	1.97357401
76	Postural instability (HP:0002172)	1.96669688
77	Thickened helices (HP:0000391)	1.94821563
78	Self-mutilation (HP:0000742)	1.94768741
79	Infertility (HP:0000789)	1.94269474
80	Cutaneous melanoma (HP:0012056)	1.92660157
81	Abnormality of the 2nd finger (HP:0004100)	1.92091466
82	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91733101
83	Retinal atrophy (HP:0001105)	1.90349761
84	Increased number of teeth (HP:0011069)	1.89637108
85	Hypoplastic labia majora (HP:0000059)	1.89411435
86	Bifid scrotum (HP:0000048)	1.87738096
87	Anterior segment dysgenesis (HP:0007700)	1.87324404
88	Enlarged kidneys (HP:0000105)	1.85365283
89	Abnormality of the labia majora (HP:0012881)	1.84306435
90	Inability to walk (HP:0002540)	1.82144033
91	Thoracolumbar scoliosis (HP:0002944)	1.80741430
92	Short hallux (HP:0010109)	1.80308565
93	Abnormality of chromosome stability (HP:0003220)	1.79102947
94	Median cleft lip (HP:0000161)	1.78994224
95	Optic nerve hypoplasia (HP:0000609)	1.78421641
96	Secondary amenorrhea (HP:0000869)	1.75732604
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74442868
98	Partial duplication of the phalanx of hand (HP:0009999)	1.73721527
99	Nephronophthisis (HP:0000090)	1.71472969
100	Renal dysplasia (HP:0000110)	1.71069694

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.84106614
2	MARK3	4.90283616
3	MST4	3.51148932
4	ACVR1B	3.36901361
5	FRK	3.30971481
6	ZAK	3.13438385
7	TLK1	3.07575573
8	BMPR1B	3.00846307
9	TNIK	2.84032390
10	NEK2	2.07338101
11	BRSK2	1.97940311
12	RPS6KA5	1.90698480
13	MYLK	1.88807985
14	STK38L	1.79477438
15	CDK12	1.69057616
16	MAP3K9	1.67937708
17	EIF2AK3	1.67782769
18	EPHA2	1.49174277
19	MKNK2	1.44684265
20	LATS1	1.31728547
21	TGFBR1	1.25649478
22	STK39	1.14560092
23	ADRBK2	1.12078499
24	PLK4	1.10202887
25	OXSR1	0.97380805
26	CSNK1A1L	0.93156710
27	FGFR2	0.93001519
28	VRK1	0.92474453
29	NUAK1	0.92203575
30	TAOK2	0.91191628
31	MELK	0.90355527
32	CDK3	0.90230442
33	AKT3	0.88797519
34	CSNK1G1	0.88443223
35	CDC7	0.86725414
36	WEE1	0.84180933
37	GRK1	0.82941786
38	STK3	0.80369358
39	STK38	0.78498019
40	CSNK1G3	0.77678825
41	WNK3	0.73491362
42	TAOK1	0.70683906
43	STK10	0.69531738
44	MAP3K10	0.69460813
45	CDK8	0.67568210
46	CSNK1G2	0.66080228
47	PKN2	0.65547383
48	PRKCQ	0.64724417
49	LATS2	0.63880026
50	TRIM28	0.63601647
51	PAK3	0.62752971
52	MAP2K7	0.61321198
53	ADRBK1	0.59785867
54	NLK	0.58152105
55	MAPK15	0.57424036
56	OBSCN	0.54899969
57	PLK1	0.54847736
58	MKNK1	0.53907777
59	ILK	0.53875802
60	BRSK1	0.53294497
61	PHKG2	0.52373227
62	PHKG1	0.52373227
63	MAP2K1	0.51777825
64	SGK494	0.51647105
65	SGK223	0.51647105
66	PBK	0.50645093
67	NME2	0.49317657
68	MAP3K5	0.45483339
69	ATM	0.44656969
70	CDK7	0.42816711
71	EPHA4	0.42345601
72	CASK	0.41610008
73	BRD4	0.40527679
74	PAK1	0.39221239
75	STK4	0.38797080
76	AURKB	0.36284838
77	PRKAA1	0.35958833
78	PRKAA2	0.35427160
79	PLK3	0.34760725
80	CSNK1E	0.34332241
81	STK11	0.34294692
82	MAP2K3	0.33939560
83	TIE1	0.32682096
84	PRKD3	0.32089262
85	AKT2	0.31573225
86	BUB1	0.31571967
87	CSNK1A1	0.31513116
88	MAP3K3	0.31281149
89	FGFR1	0.30752047
90	ROCK1	0.30552408
91	MAP3K1	0.29617613
92	DYRK3	0.29591257
93	PLK2	0.29486018
94	PRKCI	0.29154623
95	MAP3K13	0.28387257
96	CHEK2	0.27906052
97	IKBKB	0.27157919
98	CSNK2A1	0.26316346
99	KSR1	0.25718048
100	STK24	0.25136739

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	5.08348068
2	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.52207599
3	Gap junction_Homo sapiens_hsa04540	3.22788452
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.98185191
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.72307924
6	Basal transcription factors_Homo sapiens_hsa03022	2.64590931
7	RNA polymerase_Homo sapiens_hsa03020	2.54508590
8	Phototransduction_Homo sapiens_hsa04744	2.23735979
9	Olfactory transduction_Homo sapiens_hsa04740	2.21589088
10	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.00782988
11	Circadian rhythm_Homo sapiens_hsa04710	1.95812963
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.89675086
13	Arginine biosynthesis_Homo sapiens_hsa00220	1.78799074
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75533782
15	Pyruvate metabolism_Homo sapiens_hsa00620	1.65592121
16	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.65195290
17	Alcoholism_Homo sapiens_hsa05034	1.64832715
18	mRNA surveillance pathway_Homo sapiens_hsa03015	1.62977001
19	RNA transport_Homo sapiens_hsa03013	1.53724623
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53277251
21	Apoptosis_Homo sapiens_hsa04210	1.49929301
22	Glutathione metabolism_Homo sapiens_hsa00480	1.47679342
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46500816
24	Propanoate metabolism_Homo sapiens_hsa00640	1.45825206
25	Homologous recombination_Homo sapiens_hsa03440	1.40155415
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.38655840
27	Butanoate metabolism_Homo sapiens_hsa00650	1.38390914
28	Caffeine metabolism_Homo sapiens_hsa00232	1.37644287
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.36120307
30	RNA degradation_Homo sapiens_hsa03018	1.34447343
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.28010659
32	Wnt signaling pathway_Homo sapiens_hsa04310	1.26810595
33	Hippo signaling pathway_Homo sapiens_hsa04390	1.23187749
34	Glucagon signaling pathway_Homo sapiens_hsa04922	1.21941999
35	Sulfur relay system_Homo sapiens_hsa04122	1.16939958
36	Oocyte meiosis_Homo sapiens_hsa04114	1.13483709
37	Basal cell carcinoma_Homo sapiens_hsa05217	1.12222256
38	Phagosome_Homo sapiens_hsa04145	1.11796589
39	Proteasome_Homo sapiens_hsa03050	1.07936515
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07005399
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06182105
42	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.04870797
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00523950
44	Cell cycle_Homo sapiens_hsa04110	0.99893539
45	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.99686228
46	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.95912371
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95424861
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93600763
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.92579806
50	Purine metabolism_Homo sapiens_hsa00230	0.92278367
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90841561
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90083390
53	Parkinsons disease_Homo sapiens_hsa05012	0.89198663
54	Regulation of autophagy_Homo sapiens_hsa04140	0.88779309
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84970964
56	Folate biosynthesis_Homo sapiens_hsa00790	0.81867598
57	Huntingtons disease_Homo sapiens_hsa05016	0.79147615
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78944344
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.78892779
60	One carbon pool by folate_Homo sapiens_hsa00670	0.77170556
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76358367
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75459940
63	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74356099
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.71498197
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71122826
66	Melanoma_Homo sapiens_hsa05218	0.69780701
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67392481
68	Oxidative phosphorylation_Homo sapiens_hsa00190	0.64287474
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.60911817
70	Retinol metabolism_Homo sapiens_hsa00830	0.59322617
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.56769392
72	Renin secretion_Homo sapiens_hsa04924	0.53677313
73	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52837416
74	Taste transduction_Homo sapiens_hsa04742	0.52192711
75	Spliceosome_Homo sapiens_hsa03040	0.51581403
76	Melanogenesis_Homo sapiens_hsa04916	0.50246409
77	DNA replication_Homo sapiens_hsa03030	0.49757032
78	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.47415983
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.46476625
80	Nucleotide excision repair_Homo sapiens_hsa03420	0.45438550
81	Metabolic pathways_Homo sapiens_hsa01100	0.43988892
82	FoxO signaling pathway_Homo sapiens_hsa04068	0.42675634
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42509824
84	Nicotine addiction_Homo sapiens_hsa05033	0.42383117
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42075964
86	Peroxisome_Homo sapiens_hsa04146	0.40292073
87	Alzheimers disease_Homo sapiens_hsa05010	0.36481679
88	Circadian entrainment_Homo sapiens_hsa04713	0.34409082
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30878679
90	Gastric acid secretion_Homo sapiens_hsa04971	0.30853730
91	Adherens junction_Homo sapiens_hsa04520	0.29577188
92	Protein export_Homo sapiens_hsa03060	0.29259479
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.26868282
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.25797989
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.25679820
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24488017
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.24365355
98	Tight junction_Homo sapiens_hsa04530	0.23643100
99	Amphetamine addiction_Homo sapiens_hsa05031	0.23056830
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.22717254

AKAP17BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »