AKAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.49430415
2plasma membrane repair (GO:0001778)4.31974214
3skin morphogenesis (GO:0043589)4.20841039
4lymphangiogenesis (GO:0001946)4.19884994
5substrate-dependent cell migration (GO:0006929)4.18201522
6retina vasculature morphogenesis in camera-type eye (GO:0061299)3.97389108
7cardiac myofibril assembly (GO:0055003)3.94466306
8chondrocyte proliferation (GO:0035988)3.88682110
9neuron projection extension involved in neuron projection guidance (GO:1902284)3.84532289
10axon extension involved in axon guidance (GO:0048846)3.84532289
11basement membrane organization (GO:0071711)3.81736831
12cell adhesion mediated by integrin (GO:0033627)3.73451511
13endocardial cushion development (GO:0003197)3.66655785
14hippo signaling (GO:0035329)3.56095580
15glomerular basement membrane development (GO:0032836)3.55126497
16sprouting angiogenesis (GO:0002040)3.53501102
17cell migration involved in sprouting angiogenesis (GO:0002042)3.50300709
18renal filtration (GO:0097205)3.49825172
19sarcomere organization (GO:0045214)3.48899661
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46500664
21membrane raft organization (GO:0031579)3.46409637
22cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.44284735
23regulation of tight junction assembly (GO:2000810)3.40330525
24collagen fibril organization (GO:0030199)3.39053449
25wound healing, spreading of epidermal cells (GO:0035313)3.35673132
26adhesion of symbiont to host cell (GO:0044650)3.34559611
27virion attachment to host cell (GO:0019062)3.34559611
28regulation of cardioblast differentiation (GO:0051890)3.33767480
29blood vessel maturation (GO:0001955)3.33440448
30lymph vessel development (GO:0001945)3.33411296
31endothelial cell morphogenesis (GO:0001886)3.32052862
32glomerular filtration (GO:0003094)3.30695278
33positive regulation of blood vessel endothelial cell migration (GO:0043536)3.30465242
34epithelial cell-cell adhesion (GO:0090136)3.25894080
35fibroblast migration (GO:0010761)3.25229894
36negative regulation of anoikis (GO:2000811)3.23969783
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.23584504
38wound healing, spreading of cells (GO:0044319)3.21013378
39protein heterotrimerization (GO:0070208)3.18140930
40barbed-end actin filament capping (GO:0051016)3.17464993
41sequestering of extracellular ligand from receptor (GO:0035581)3.13627458
42cellular response to vitamin (GO:0071295)3.13580909
43myofibril assembly (GO:0030239)3.13450116
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12633389
45surfactant homeostasis (GO:0043129)3.11813762
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10704418
47endodermal cell differentiation (GO:0035987)3.10542774
48stress fiber assembly (GO:0043149)3.10440267
49glomerular visceral epithelial cell development (GO:0072015)3.08721464
50type B pancreatic cell proliferation (GO:0044342)3.04831348
51cell-substrate junction assembly (GO:0007044)3.04461633
52adherens junction assembly (GO:0034333)3.03150297
53artery development (GO:0060840)3.01666458
54negative regulation of smooth muscle cell migration (GO:0014912)3.01024358
55insulin-like growth factor receptor signaling pathway (GO:0048009)3.00948919
56endothelium development (GO:0003158)2.98080392
57pinocytosis (GO:0006907)2.97460686
58atrioventricular valve morphogenesis (GO:0003181)2.94430619
59protein localization to endosome (GO:0036010)2.93429146
60extracellular matrix assembly (GO:0085029)2.93135336
61vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.92555978
62blood vessel endothelial cell migration (GO:0043534)2.90474738
63regulation of p38MAPK cascade (GO:1900744)2.90254810
64collagen metabolic process (GO:0032963)2.89868385
65regulation of endothelial cell differentiation (GO:0045601)2.88966662
66hyaluronan catabolic process (GO:0030214)2.88451553
67heart trabecula formation (GO:0060347)2.87475614
68cell migration involved in heart development (GO:0060973)2.86615225
69heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.85854692
70hypotonic response (GO:0006971)2.84548424
71regulation of early endosome to late endosome transport (GO:2000641)2.84501506
72Golgi transport vesicle coating (GO:0048200)2.84246314
73COPI coating of Golgi vesicle (GO:0048205)2.84246314
74adhesion of symbiont to host (GO:0044406)2.84233070
75positive regulation of receptor recycling (GO:0001921)2.84139931
76actomyosin structure organization (GO:0031032)2.83482952
77positive regulation of p38MAPK cascade (GO:1900745)2.82489764
78branching involved in salivary gland morphogenesis (GO:0060445)2.80323363
79extracellular fibril organization (GO:0043206)2.80154327
80positive regulation of macrophage activation (GO:0043032)2.77683884
81glomerular epithelial cell development (GO:0072310)2.77659599
82positive regulation of endothelial cell migration (GO:0010595)2.76765848
83mesenchymal-epithelial cell signaling (GO:0060638)2.76307433
84apoptotic cell clearance (GO:0043277)2.75242535
85venous blood vessel morphogenesis (GO:0048845)2.74693605
86regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74673354
87endothelial tube morphogenesis (GO:0061154)2.74164458
88morphogenesis of an endothelium (GO:0003159)2.74164458
89regulation of endothelial cell apoptotic process (GO:2000351)2.74127529
90patterning of blood vessels (GO:0001569)2.73994804
91negative regulation of chondrocyte differentiation (GO:0032331)2.73659377
92positive regulation of fibroblast migration (GO:0010763)2.73448712
93kidney mesenchyme development (GO:0072074)2.73442289
94hemidesmosome assembly (GO:0031581)2.73292818
95negative regulation of fatty acid transport (GO:2000192)2.72855280
96actin-myosin filament sliding (GO:0033275)2.72588093
97muscle filament sliding (GO:0030049)2.72588093
98negative regulation of focal adhesion assembly (GO:0051895)2.72157380
99negative regulation of cell junction assembly (GO:1901889)2.72157380
100negative regulation of adherens junction organization (GO:1903392)2.72157380
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71701356
102regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71379190
103polarized epithelial cell differentiation (GO:0030859)2.71355093
104fibril organization (GO:0097435)2.71257383
105substrate adhesion-dependent cell spreading (GO:0034446)2.71021051
106cardiac muscle cell development (GO:0055013)2.69783037
107blood vessel remodeling (GO:0001974)2.68214176
108cortical actin cytoskeleton organization (GO:0030866)2.68086151
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67484675
110collagen catabolic process (GO:0030574)2.67439681
111endocytic recycling (GO:0032456)2.65645153
112extracellular matrix disassembly (GO:0022617)2.65261257
113regulation of anoikis (GO:2000209)2.65228362
114mesodermal cell differentiation (GO:0048333)2.65031430
115protein localization to cell surface (GO:0034394)2.63598275
116multicellular organismal macromolecule metabolic process (GO:0044259)2.63516941
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.63220759
118cardiac cell development (GO:0055006)2.61392246
119negative regulation of potassium ion transmembrane transport (GO:1901380)2.60640186
120trabecula formation (GO:0060343)2.60178245
121cell-substrate adherens junction assembly (GO:0007045)2.60016042
122focal adhesion assembly (GO:0048041)2.60016042
123regulation of transforming growth factor beta1 production (GO:0032908)2.58741330
124platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58547393
125negative regulation of catenin import into nucleus (GO:0035414)2.57846270
126coronary vasculature morphogenesis (GO:0060977)2.57257740
127positive regulation of epithelial cell migration (GO:0010634)2.57243917
128actin-mediated cell contraction (GO:0070252)2.56044646
129regulation of transforming growth factor beta2 production (GO:0032909)2.54099534
130regulation of axon extension involved in axon guidance (GO:0048841)2.53202891
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52685355
132pericardium development (GO:0060039)2.52681260
133cellular response to vitamin D (GO:0071305)2.51685333
134bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51160097
135paraxial mesoderm development (GO:0048339)2.50918042
136positive regulation of endothelial cell apoptotic process (GO:2000353)2.50744442
137embryonic foregut morphogenesis (GO:0048617)2.50742599
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.50487045
139heart morphogenesis (GO:0003007)2.50085999
140multicellular organismal metabolic process (GO:0044236)2.49768442
141regulation of plasminogen activation (GO:0010755)2.49286587
142regulation of integrin-mediated signaling pathway (GO:2001044)2.48896520
143angiogenesis involved in wound healing (GO:0060055)2.48200003
144negative regulation of heart growth (GO:0061117)2.47922057
145negative regulation of cardiac muscle tissue growth (GO:0055022)2.47922057
146cardiac muscle cell proliferation (GO:0060038)2.47419188
147lung vasculature development (GO:0060426)2.46022920
148atrial septum morphogenesis (GO:0060413)2.44927224
149negative regulation of nitric-oxide synthase activity (GO:0051001)2.44367242
150chemical homeostasis within a tissue (GO:0048875)2.44186475
151bone trabecula formation (GO:0060346)2.43567377
152actin filament-based movement (GO:0030048)2.43550396
153protein targeting to plasma membrane (GO:0072661)2.42365860
154regulation of heart morphogenesis (GO:2000826)2.41139411
155metanephric mesenchyme development (GO:0072075)2.39717662
156negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.39473000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.75312964
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.46626717
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.14882149
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99506209
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.92893277
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78311689
7CLOCK_20551151_ChIP-Seq_293T_Human2.77860532
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.40138769
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31912036
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.14022564
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.12756480
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05220665
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98666473
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97737244
15* CJUN_26792858_Chip-Seq_BT549_Human1.96676304
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96611661
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.95800500
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.91095070
19TBX20_22328084_ChIP-Seq_HEART_Mouse1.88521822
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.88521822
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87568516
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.87327098
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86600960
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82970333
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.82804824
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.78794101
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.78154548
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77173218
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69747781
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69743302
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69337054
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69315558
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68937471
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62107802
35* BRD4_25478319_ChIP-Seq_HGPS_Human1.60564815
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54314740
37* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54068799
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53827027
39* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50956142
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48143689
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48143689
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.47581039
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47545246
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47490234
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47112123
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47112123
47* FOXO3_23340844_ChIP-Seq_DLD1_Human1.47083925
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46637049
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45022736
50TP53_16413492_ChIP-PET_HCT116_Human1.44072386
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44049027
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42168292
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41317005
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40218432
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39104658
56* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39104658
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38964442
58AHR_22903824_ChIP-Seq_MCF-7_Human1.38688058
59* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38674965
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37572045
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37315643
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37021352
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35742443
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.34468864
65NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33676184
66AR_21909140_ChIP-Seq_LNCAP_Human1.32988275
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32007667
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31951486
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.31811150
70TP53_22127205_ChIP-Seq_IMR90_Human1.31253300
71* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30891381
72TP53_18474530_ChIP-ChIP_U2OS_Human1.30705910
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30497866
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27921982
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27701889
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.25448613
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22441359
78* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19699879
79KDM2B_26808549_Chip-Seq_K562_Human1.19665422
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16424355
81ZNF263_19887448_ChIP-Seq_K562_Human1.15332229
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15317982
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.15293596
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.13842326
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.13613156
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13550769
87* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13437864
88* SOX2_20726797_ChIP-Seq_SW620_Human1.12821201
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12591796
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10621919
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10396779
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09129300
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07480675
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07141335
95RXR_22108803_ChIP-Seq_LS180_Human1.06929903
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06328730
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05789704
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05241761
99* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05198379
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04555305
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.04214255
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04012711
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03205053
104PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03139478
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02557265
106* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02000872
107BCAT_22108803_ChIP-Seq_LS180_Human1.01815298
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01626544
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01118446
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.01089405
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00889965
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00855351
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98971095
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98761624
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98490021
116SA1_22415368_ChIP-Seq_MEFs_Mouse0.98044191
117RACK7_27058665_Chip-Seq_MCF-7_Human0.97524626
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97011912
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96916075
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.95115277
121* PIAS1_25552417_ChIP-Seq_VCAP_Human0.93862276
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93401424
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93398967
124ATF3_27146783_Chip-Seq_COLON_Human0.93084363
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92811386
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91685244
127SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91635067
128VDR_24787735_ChIP-Seq_THP-1_Human0.90580018
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90392481
130* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90143323
131TCF7_22412390_ChIP-Seq_EML_Mouse0.89938777
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.88403129
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87202479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.53296475
2MP0004272_abnormal_basement_membrane3.83540073
3MP0005623_abnormal_meninges_morphology3.38645406
4MP0003705_abnormal_hypodermis_morpholog3.29634433
5MP0004084_abnormal_cardiac_muscle3.27949483
6MP0010368_abnormal_lymphatic_system3.20353434
7MP0005275_abnormal_skin_tensile2.87830653
8MP0005503_abnormal_tendon_morphology2.81961020
9MP0001958_emphysema2.78461987
10MP0003279_aneurysm2.72750035
11MP0001879_abnormal_lymphatic_vessel2.49781543
12MP0003566_abnormal_cell_adhesion2.47380365
13MP0000751_myopathy2.37090801
14MP0002837_dystrophic_cardiac_calcinosis2.17650494
15MP0006138_congestive_heart_failure2.10453110
16MP0003091_abnormal_cell_migration2.08798821
17MP0000750_abnormal_muscle_regeneration1.99460700
18MP0008775_abnormal_heart_ventricle1.92544135
19MP0000733_abnormal_muscle_development1.90483964
20MP0003828_pulmonary_edema1.89373593
21MP0005330_cardiomyopathy1.88562260
22MP0004036_abnormal_muscle_relaxation1.86285150
23MP0004215_abnormal_myocardial_fiber1.86073102
24MP0001542_abnormal_bone_strength1.82052306
25MP0004087_abnormal_muscle_fiber1.81313896
26MP0009384_cardiac_valve_regurgitation1.78569204
27MP0000767_abnormal_smooth_muscle1.78072044
28MP0003303_peritoneal_inflammation1.71841435
29MP0010630_abnormal_cardiac_muscle1.67751128
30MP0002972_abnormal_cardiac_muscle1.66614415
31MP0002877_abnormal_melanocyte_morpholog1.63239424
32MP0001544_abnormal_cardiovascular_syste1.59775378
33MP0005385_cardiovascular_system_phenoty1.59775378
34MP0010352_gastrointestinal_tract_polyps1.59277815
35MP0002295_abnormal_pulmonary_circulatio1.58822149
36MP0000749_muscle_degeneration1.58383846
37MP0006054_spinal_hemorrhage1.48065236
38MP0003385_abnormal_body_wall1.44585534
39MP0004484_altered_response_of1.42931467
40MP0005023_abnormal_wound_healing1.41881836
41MP0005620_abnormal_muscle_contractility1.41811456
42MP0002108_abnormal_muscle_morphology1.41810658
43MP0003045_fibrosis1.41188195
44MP0005171_absent_coat_pigmentation1.35403659
45MP0003950_abnormal_plasma_membrane1.33078620
46MP0005508_abnormal_skeleton_morphology1.31482237
47MP0003941_abnormal_skin_development1.29984806
48MP0003191_abnormal_cellular_cholesterol1.29684508
49MP0004510_myositis1.29025124
50MP0010030_abnormal_orbit_morphology1.27293331
51MP0009840_abnormal_foam_cell1.27201036
52MP0004233_abnormal_muscle_weight1.26948903
53MP0003448_altered_tumor_morphology1.25438460
54MP0005167_abnormal_blood-brain_barrier1.23356549
55MP0002925_abnormal_cardiovascular_devel1.23060598
56MP0002128_abnormal_blood_circulation1.22470586
57MP0009250_abnormal_appendicular_skeleto1.21401540
58MP0005257_abnormal_intraocular_pressure1.19832473
59MP0001299_abnormal_eye_distance/1.18357781
60MP0000534_abnormal_ureter_morphology1.16888506
61MP0000013_abnormal_adipose_tissue1.16379114
62MP0002332_abnormal_exercise_endurance1.15313856
63MP0001849_ear_inflammation1.14795284
64MP0000759_abnormal_skeletal_muscle1.14674691
65MP0002998_abnormal_bone_remodeling1.13836039
66MP0002106_abnormal_muscle_physiology1.12245934
67MP0001348_abnormal_lacrimal_gland1.10926576
68MP0001915_intracranial_hemorrhage1.10423620
69MP0005369_muscle_phenotype1.10299650
70MP0003453_abnormal_keratinocyte_physiol1.10298947
71MP0005451_abnormal_body_composition1.08523479
72MP0002896_abnormal_bone_mineralization1.07558306
73MP0000516_abnormal_urinary_system1.05526545
74MP0005367_renal/urinary_system_phenotyp1.05526545
75MP0001614_abnormal_blood_vessel1.05273973
76MP0000266_abnormal_heart_morphology1.04424876
77MP0004085_abnormal_heartbeat1.03433275
78MP0008004_abnormal_stomach_pH1.02949424
79MP0001243_abnormal_dermal_layer1.01969843
80MP0004130_abnormal_muscle_cell1.01814243
81MP0000003_abnormal_adipose_tissue1.01575516
82MP0003567_abnormal_fetal_cardiomyocyte1.01492365
83MP0002254_reproductive_system_inflammat1.00673344
84MP0003137_abnormal_impulse_conducting0.99616312
85MP0000858_altered_metastatic_potential0.99335825
86MP0005388_respiratory_system_phenotype0.98668874
87MP0002133_abnormal_respiratory_system0.98668874
88MP0002269_muscular_atrophy0.98443398
89MP0009780_abnormal_chondrocyte_physiolo0.98116152
90MP0002127_abnormal_cardiovascular_syste0.97923417
91MP0002168_other_aberrant_phenotype0.95377107
92MP0003942_abnormal_urinary_system0.94520424
93MP0002933_joint_inflammation0.93958697
94MP0003115_abnormal_respiratory_system0.93712174
95MP0005595_abnormal_vascular_smooth0.93242489
96MP0003935_abnormal_craniofacial_develop0.92916558
97MP0000343_altered_response_to0.92744643
98MP0000537_abnormal_urethra_morphology0.92065155
99MP0000249_abnormal_blood_vessel0.90431404
100MP0000747_muscle_weakness0.89822528
101MP0005076_abnormal_cell_differentiation0.89102963
102MP0005375_adipose_tissue_phenotype0.87416336
103MP0009053_abnormal_anal_canal0.86171004
104MP0005666_abnormal_adipose_tissue0.85138058
105MP0005390_skeleton_phenotype0.84970997
106MP0004145_abnormal_muscle_electrophysio0.84354613
107MP0004185_abnormal_adipocyte_glucose0.84180429
108MP0005248_abnormal_Harderian_gland0.81967634
109MP0005058_abnormal_lysosome_morphology0.81723724
110MP0000428_abnormal_craniofacial_morphol0.80911035
111MP0005165_increased_susceptibility_to0.80809243
112MP0001175_abnormal_lung_morphology0.80791217
113MP0005164_abnormal_response_to0.79337374
114MP0005197_abnormal_uvea_morphology0.78853922
115MP0004947_skin_inflammation0.77931647
116MP0001533_abnormal_skeleton_physiology0.77655390
117MP0002234_abnormal_pharynx_morphology0.77586614
118MP0005621_abnormal_cell_physiology0.77223838
119MP0003300_gastrointestinal_ulcer0.75806339
120MP0002060_abnormal_skin_morphology0.75685498
121MP0002932_abnormal_joint_morphology0.75067146
122MP0000163_abnormal_cartilage_morphology0.74982954
123MP0003868_abnormal_feces_composition0.71293159
124MP0005409_darkened_coat_color0.71172157
125MP0004808_abnormal_hematopoietic_stem0.69594103
126MP0005193_abnormal_anterior_eye0.62771998
127MP0003795_abnormal_bone_structure0.61512627
128MP0000762_abnormal_tongue_morphology0.60802852
129MP0002113_abnormal_skeleton_development0.60537989
130MP0004782_abnormal_surfactant_physiolog0.60390467
131MP0005670_abnormal_white_adipose0.60380331

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.31105501
2Protrusio acetabuli (HP:0003179)5.28372509
3Cerebral aneurysm (HP:0004944)4.05818077
4Shallow orbits (HP:0000586)4.03673307
5Broad metatarsal (HP:0001783)3.91907416
6Right ventricular cardiomyopathy (HP:0011663)3.81892154
7Increased connective tissue (HP:0009025)3.76925707
8Muscle fiber splitting (HP:0003555)3.64774872
9Sudden death (HP:0001699)3.62419597
10Ankle contracture (HP:0006466)3.57357191
11Aortic dissection (HP:0002647)3.57076412
12Aortic aneurysm (HP:0004942)3.56111947
13Hyporeflexia of lower limbs (HP:0002600)3.35235202
14Atrophic scars (HP:0001075)3.25058441
15Spondylolisthesis (HP:0003302)3.09343745
16Vertebral compression fractures (HP:0002953)3.02891545
17Spinal rigidity (HP:0003306)2.98633155
18Ventricular tachycardia (HP:0004756)2.94642549
19Aneurysm (HP:0002617)2.86771336
20Abnormality of the calf musculature (HP:0001430)2.85854980
21Atrial fibrillation (HP:0005110)2.83953158
22Difficulty climbing stairs (HP:0003551)2.83112401
23Type 1 muscle fiber predominance (HP:0003803)2.80625299
24Bladder diverticulum (HP:0000015)2.78760362
25Mildly elevated creatine phosphokinase (HP:0008180)2.74498223
26Hematochezia (HP:0002573)2.72444780
27Mitral valve prolapse (HP:0001634)2.71195741
28Scapular winging (HP:0003691)2.68895500
29Lipoatrophy (HP:0100578)2.68140483
30Difficulty running (HP:0009046)2.67674801
31Primary atrial arrhythmia (HP:0001692)2.67622416
32Cervical subluxation (HP:0003308)2.65145005
33Dilatation of the ascending aorta (HP:0005111)2.63029342
34Supraventricular arrhythmia (HP:0005115)2.60906112
35Increased variability in muscle fiber diameter (HP:0003557)2.58985371
36Wrist flexion contracture (HP:0001239)2.58831243
37Lymphangioma (HP:0100764)2.54323645
38Fragile skin (HP:0001030)2.51841694
39Supraventricular tachycardia (HP:0004755)2.47842892
40Soft skin (HP:0000977)2.44896930
41Peritonitis (HP:0002586)2.43841097
42Vascular tortuosity (HP:0004948)2.42436794
43Exercise-induced muscle cramps (HP:0003710)2.36041222
44Slender build (HP:0001533)2.33236066
45Distal lower limb amyotrophy (HP:0008944)2.31733727
46Syringomyelia (HP:0003396)2.31088762
47Spinal cord lesions (HP:0100561)2.31088762
48Mitral regurgitation (HP:0001653)2.30744067
49Polycythemia (HP:0001901)2.29691539
50Camptodactyly of toe (HP:0001836)2.27054986
51Natal tooth (HP:0000695)2.26508805
52EMG: myopathic abnormalities (HP:0003458)2.25455567
53Reduced subcutaneous adipose tissue (HP:0003758)2.25216856
54Interstitial pulmonary disease (HP:0006530)2.24161180
55Abnormality of skeletal muscle fiber size (HP:0012084)2.24063916
56Disproportionate tall stature (HP:0001519)2.21718066
57Thoracolumbar scoliosis (HP:0002944)2.21206094
58Arterial tortuosity (HP:0005116)2.20232046
59Aortic regurgitation (HP:0001659)2.19126895
60Wormian bones (HP:0002645)2.18841023
61Subacute progressive viral hepatitis (HP:0006572)2.18378735
62Overgrowth (HP:0001548)2.16732161
63Myocardial infarction (HP:0001658)2.16134172
64Blue sclerae (HP:0000592)2.13897972
65Genu recurvatum (HP:0002816)2.13181620
66Calf muscle hypertrophy (HP:0008981)2.12733590
67Mitral stenosis (HP:0001718)2.12431900
68Abnormality of dentin (HP:0010299)2.09428234
69Hypoplasia of the iris (HP:0007676)2.06263862
70Aortic valve stenosis (HP:0001650)2.05429192
71Abnormality of the acetabulum (HP:0003170)2.03235385
72Pulmonary artery stenosis (HP:0004415)2.00983263
73Venous abnormality (HP:0002624)2.00025490
74Hip contracture (HP:0003273)1.99974377
75Abnormality of the left ventricular outflow tract (HP:0011103)1.99487854
76Subaortic stenosis (HP:0001682)1.99487854
77Hyperextensible skin (HP:0000974)1.98095515
78Upper limb amyotrophy (HP:0009129)1.97745856
79Distal upper limb amyotrophy (HP:0007149)1.97745856
80Osteolytic defects of the phalanges of the hand (HP:0009771)1.97616128
81Osteolytic defects of the hand bones (HP:0009699)1.97616128
82Rectal prolapse (HP:0002035)1.96852419
83Ectopia lentis (HP:0001083)1.95067142
84Round ear (HP:0100830)1.94925768
85Cardiovascular calcification (HP:0011915)1.94630316
86Neonatal short-limb short stature (HP:0008921)1.94506634
87Short 4th metacarpal (HP:0010044)1.93613100
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93613100
89Achilles tendon contracture (HP:0001771)1.92611945
90Lower limb amyotrophy (HP:0007210)1.92411479
91Buphthalmos (HP:0000557)1.91895419
92Joint stiffness (HP:0001387)1.91425022
93Knee flexion contracture (HP:0006380)1.90433604
94Generalized amyotrophy (HP:0003700)1.89639122
95Broad face (HP:0000283)1.88594698
96Persistence of primary teeth (HP:0006335)1.88335151
97Long toe (HP:0010511)1.87884945
98Wide anterior fontanel (HP:0000260)1.87850641
99Tetraparesis (HP:0002273)1.84984100
100Visceral angiomatosis (HP:0100761)1.84709179
101Venous insufficiency (HP:0005293)1.84029652
102Thin bony cortex (HP:0002753)1.83803818
103Follicular hyperkeratosis (HP:0007502)1.83531986
104Nuclear cataract (HP:0100018)1.83042810
105Emphysema (HP:0002097)1.81819368
106Short nail (HP:0001799)1.81774244
107Coronal craniosynostosis (HP:0004440)1.81302543
108Hypoplastic ischia (HP:0003175)1.80204705
109Asymmetric septal hypertrophy (HP:0001670)1.80000943
110Abnormality of the 4th metacarpal (HP:0010012)1.78578349
111Ovoid vertebral bodies (HP:0003300)1.78515382
112Muscle hypertrophy of the lower extremities (HP:0008968)1.78415139
113Ventricular arrhythmia (HP:0004308)1.77910175
114Dilated cardiomyopathy (HP:0001644)1.77832679
115Ulnar bowing (HP:0003031)1.77747250
116Elbow flexion contracture (HP:0002987)1.77034466
117Bowel diverticulosis (HP:0005222)1.76467067
118Coxa vara (HP:0002812)1.75793562
119Bronchomalacia (HP:0002780)1.74234856
120Deviation of the hallux (HP:0010051)1.74018700
121Increased mean platelet volume (HP:0011877)1.73808119
122Striae distensae (HP:0001065)1.73358014
123Syncope (HP:0001279)1.73152890
124Hemangiomatosis (HP:0007461)1.72963215
125Enlarged penis (HP:0000040)1.72457337
126Delayed closure of the anterior fontanelle (HP:0001476)1.71899937
127Distal lower limb muscle weakness (HP:0009053)1.71186043
128Joint contractures involving the joints of the feet (HP:0100492)1.71159729
129Flexion contracture of toe (HP:0005830)1.71159729
130Absent frontal sinuses (HP:0002688)1.70891059
131Limited hip movement (HP:0008800)1.70833216
132Protruding ear (HP:0000411)1.69236368
133Joint laxity (HP:0001388)1.68746616
134Nonimmune hydrops fetalis (HP:0001790)1.67713420
135Delayed cranial suture closure (HP:0000270)1.67624512
136Abnormal delivery (HP:0001787)1.66551106
137Esophageal varix (HP:0002040)1.65760698
138Abnormality of the Achilles tendon (HP:0005109)1.63526940
139Abnormality of oral frenula (HP:0000190)1.62388087
140Cupped ribs (HP:0000887)1.62155736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.75288493
2TIE13.49642496
3TRIB33.37007049
4LATS13.22674635
5DDR23.00103813
6PDGFRA2.82917366
7IRAK32.72754721
8RIPK12.67633500
9DMPK2.59981613
10LATS22.48972517
11PKN22.32165672
12PRPF4B2.27656370
13EPHB22.20369894
14MYLK2.09060587
15FER2.06221357
16TGFBR22.00559465
17EPHA31.75373308
18PTK2B1.61552405
19BMX1.60869572
20ERBB41.60512315
21TESK11.57041176
22KDR1.55265789
23LMTK21.46603029
24PAK31.46384658
25SIK11.45533291
26OBSCN1.41061737
27PAK21.40242345
28PTK21.38974663
29PTK61.38569721
30PAK41.37474977
31STK38L1.35222527
32CLK11.33872885
33LRRK21.26774311
34PIK3CA1.23669851
35TAOK21.21725833
36EPHB11.21653848
37FGFR41.20564584
38ROCK11.16935027
39MET1.16143363
40STK31.15407290
41GRK71.15161402
42ERN11.15091759
43PDGFRB1.14019696
44MST1R1.11352185
45MOS1.07925087
46TRPM71.06901150
47MAP3K141.06134823
48TGFBR11.03595255
49FGFR31.00190092
50ILK0.99383787
51FLT30.98837094
52ABL20.97605702
53SMG10.96129674
54MTOR0.95896784
55PRKD10.92792913
56CAMK1D0.90972908
57CDC42BPA0.89238975
58PDK20.88659200
59MAP2K30.88388909
60CDK120.87785330
61RET0.86767936
62NEK90.84999655
63PDK30.84556088
64PDK40.84556088
65FGFR20.84004943
66PRKD30.83504254
67WNK10.82978754
68PHKG10.82701389
69PHKG20.82701389
70FGFR10.80097659
71MAP3K70.79615535
72MAP3K100.79430253
73ARAF0.79077259
74MELK0.78142276
75PIM20.75563507
76ROCK20.74220240
77MAP3K130.74132444
78STK380.73432942
79CAMK1G0.71886292
80SCYL20.71125485
81MAP3K60.70208846
82MAPK70.67926193
83ZAP700.66420059
84PRKG20.65592522
85TBK10.64832911
86PRKAA20.64711992
87NME20.64478201
88MAP2K10.64002339
89WNK40.63015365
90JAK10.62895350
91STK240.62728055
92PRKCH0.60252519
93NEK10.59265307
94CDK60.59204705
95RPS6KA20.58906380
96PAK60.58447452
97TYRO30.58100265
98STK100.58074409
99MAP3K30.57630292
100EPHA20.57446244
101JAK30.57149700
102MAP3K80.56267878
103CDK80.55834701
104MAPKAPK30.53410058
105TYK20.53121991
106CDK90.52925025
107NTRK10.52482380
108INSR0.52435248
109GSK3A0.52119197
110FRK0.51608427
111MAPK110.49345087
112EEF2K0.47694859
113PRKD20.46411447
114MUSK0.44765656
115SRC0.43929686
116AKT30.43001798
117PRKCE0.42664478
118DAPK30.42520003
119DYRK1B0.40298654
120MAPK40.40297566
121NUAK10.40276485
122MARK30.39645327
123PLK20.39276835
124PIK3CG0.39090664
125LIMK10.38320436
126CSK0.36993160
127KSR20.35495057
128MAP3K120.34627565
129ICK0.34607593
130KIT0.33882336
131EGFR0.33377040
132MAP3K50.33149541
133MARK20.32415064
134BMPR20.32020092
135CDK40.31860301
136GRK50.31739566
137AKT20.31652138
138IGF1R0.31115489
139PAK10.29652120
140HIPK20.29595736
141MAPKAPK20.28485370
142MAP3K10.28082697

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.10129460
2Dilated cardiomyopathy_Homo sapiens_hsa054142.97706236
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.91191585
4Focal adhesion_Homo sapiens_hsa045102.72492967
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.72421255
6Adherens junction_Homo sapiens_hsa045202.45842763
7Proteoglycans in cancer_Homo sapiens_hsa052051.99786470
8Small cell lung cancer_Homo sapiens_hsa052221.86716890
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.81527078
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.73945750
11Amoebiasis_Homo sapiens_hsa051461.71272460
12Viral myocarditis_Homo sapiens_hsa054161.65793379
13Hippo signaling pathway_Homo sapiens_hsa043901.63006496
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59533680
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54886407
16Tight junction_Homo sapiens_hsa045301.51891800
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45128751
18TGF-beta signaling pathway_Homo sapiens_hsa043501.43169097
19MicroRNAs in cancer_Homo sapiens_hsa052061.41297453
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.39537904
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38819040
22Prion diseases_Homo sapiens_hsa050201.36839663
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28750328
24Bladder cancer_Homo sapiens_hsa052191.27202093
25Protein digestion and absorption_Homo sapiens_hsa049741.25026520
26Other glycan degradation_Homo sapiens_hsa005111.24863485
27Rap1 signaling pathway_Homo sapiens_hsa040151.24332878
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20935141
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19442046
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17499714
31Melanoma_Homo sapiens_hsa052181.17411779
32Renal cell carcinoma_Homo sapiens_hsa052111.15450027
33Pertussis_Homo sapiens_hsa051331.15357344
34Basal cell carcinoma_Homo sapiens_hsa052171.13601066
35Axon guidance_Homo sapiens_hsa043601.13586284
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11328315
37HIF-1 signaling pathway_Homo sapiens_hsa040661.10285696
38Chronic myeloid leukemia_Homo sapiens_hsa052201.08829595
39Dorso-ventral axis formation_Homo sapiens_hsa043201.08514313
40Cardiac muscle contraction_Homo sapiens_hsa042601.07677125
41Pathways in cancer_Homo sapiens_hsa052001.06914148
42Hepatitis B_Homo sapiens_hsa051611.05857691
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05037796
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02755282
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.02165315
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.01671790
47Toxoplasmosis_Homo sapiens_hsa051451.00763491
48Melanogenesis_Homo sapiens_hsa049161.00099116
49Glioma_Homo sapiens_hsa052140.98793782
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.96882439
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96708624
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96632000
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96376246
54Platelet activation_Homo sapiens_hsa046110.95057582
55Insulin resistance_Homo sapiens_hsa049310.94749636
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94558465
57Ovarian steroidogenesis_Homo sapiens_hsa049130.93925725
58Pancreatic cancer_Homo sapiens_hsa052120.93856366
59Hedgehog signaling pathway_Homo sapiens_hsa043400.92299859
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92089808
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91907514
62VEGF signaling pathway_Homo sapiens_hsa043700.90556631
63African trypanosomiasis_Homo sapiens_hsa051430.88130125
64Estrogen signaling pathway_Homo sapiens_hsa049150.87513410
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87318149
66Osteoclast differentiation_Homo sapiens_hsa043800.86890590
67Prostate cancer_Homo sapiens_hsa052150.86609105
68Malaria_Homo sapiens_hsa051440.86425193
69mTOR signaling pathway_Homo sapiens_hsa041500.85633400
70Renin secretion_Homo sapiens_hsa049240.85530677
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.85281160
72Influenza A_Homo sapiens_hsa051640.85092423
73Oxytocin signaling pathway_Homo sapiens_hsa049210.85041131
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84780497
75Gap junction_Homo sapiens_hsa045400.84037670
76GnRH signaling pathway_Homo sapiens_hsa049120.82551906
77Lysosome_Homo sapiens_hsa041420.80500946
78Complement and coagulation cascades_Homo sapiens_hsa046100.80276154
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80189157
80Phagosome_Homo sapiens_hsa041450.80075619
81Hepatitis C_Homo sapiens_hsa051600.79459223
82Endometrial cancer_Homo sapiens_hsa052130.78777240
83AMPK signaling pathway_Homo sapiens_hsa041520.77817208
84Ras signaling pathway_Homo sapiens_hsa040140.77308525
85Acute myeloid leukemia_Homo sapiens_hsa052210.76705809
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.76140567
87Wnt signaling pathway_Homo sapiens_hsa043100.75609135
88p53 signaling pathway_Homo sapiens_hsa041150.72882051
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72303077
90Insulin signaling pathway_Homo sapiens_hsa049100.72237181
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69479689
92cAMP signaling pathway_Homo sapiens_hsa040240.67966356
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.67511493
94TNF signaling pathway_Homo sapiens_hsa046680.66392670
95Notch signaling pathway_Homo sapiens_hsa043300.66190788
96Measles_Homo sapiens_hsa051620.65756326
97FoxO signaling pathway_Homo sapiens_hsa040680.65578865
98B cell receptor signaling pathway_Homo sapiens_hsa046620.65492490
99MAPK signaling pathway_Homo sapiens_hsa040100.65432310
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.64662896
101Endocytosis_Homo sapiens_hsa041440.63968696
102Rheumatoid arthritis_Homo sapiens_hsa053230.63093310
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62383346
104Gastric acid secretion_Homo sapiens_hsa049710.62294681
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62032384
106Salmonella infection_Homo sapiens_hsa051320.61855539
107Glucagon signaling pathway_Homo sapiens_hsa049220.61694586
108Colorectal cancer_Homo sapiens_hsa052100.61639875
109HTLV-I infection_Homo sapiens_hsa051660.60917975
110Non-small cell lung cancer_Homo sapiens_hsa052230.60799890
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59945363
112Hematopoietic cell lineage_Homo sapiens_hsa046400.59458448
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.59414531
114Leishmaniasis_Homo sapiens_hsa051400.58897258
115Prolactin signaling pathway_Homo sapiens_hsa049170.58689382
116Shigellosis_Homo sapiens_hsa051310.58676843
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58391442
118Viral carcinogenesis_Homo sapiens_hsa052030.55333231
119Vibrio cholerae infection_Homo sapiens_hsa051100.54385476
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53859388
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52836476
122Thyroid hormone synthesis_Homo sapiens_hsa049180.52048687
123ErbB signaling pathway_Homo sapiens_hsa040120.51798490
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51700667
125N-Glycan biosynthesis_Homo sapiens_hsa005100.49283807
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48827837
127Sphingolipid metabolism_Homo sapiens_hsa006000.48235243
128PPAR signaling pathway_Homo sapiens_hsa033200.47927828
129Choline metabolism in cancer_Homo sapiens_hsa052310.45892871
130Fatty acid biosynthesis_Homo sapiens_hsa000610.45640145
131Lysine degradation_Homo sapiens_hsa003100.44656634
132Salivary secretion_Homo sapiens_hsa049700.43648704
133Type II diabetes mellitus_Homo sapiens_hsa049300.42541574
134Thyroid cancer_Homo sapiens_hsa052160.42256669
135Renin-angiotensin system_Homo sapiens_hsa046140.40309486
136Apoptosis_Homo sapiens_hsa042100.40008529

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »