AKAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.96698136
2cilium or flagellum-dependent cell motility (GO:0001539)9.95968772
3spermatid development (GO:0007286)9.81054432
4motile cilium assembly (GO:0044458)9.51421296
5reproduction (GO:0000003)9.32079051
6regulation of cilium movement (GO:0003352)9.12153747
7cilium movement (GO:0003341)8.16022639
8response to pheromone (GO:0019236)7.75161358
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.65001667
10piRNA metabolic process (GO:0034587)7.40566707
11sperm capacitation (GO:0048240)7.20507993
12synaptonemal complex organization (GO:0070193)7.14547407
13male meiosis (GO:0007140)7.14310131
14* single fertilization (GO:0007338)7.00685231
15negative regulation of inclusion body assembly (GO:0090084)6.96334669
16synaptonemal complex assembly (GO:0007130)6.89408837
17rRNA methylation (GO:0031167)6.80982372
18spermatogenesis (GO:0007283)6.74870159
19male gamete generation (GO:0048232)6.72424092
20organic cation transport (GO:0015695)6.58760167
21microtubule depolymerization (GO:0007019)6.50884432
22gamete generation (GO:0007276)6.17642859
23* fertilization (GO:0009566)6.11918347
24phosphatidylethanolamine biosynthetic process (GO:0006646)5.91249375
25protein targeting to Golgi (GO:0000042)5.89864618
26regulation of inclusion body assembly (GO:0090083)5.84083453
27establishment of protein localization to Golgi (GO:0072600)5.66343257
28rRNA modification (GO:0000154)5.58359859
29cellular ketone body metabolic process (GO:0046950)5.56026353
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.50302909
31germ cell development (GO:0007281)5.49635479
32retrograde transport, vesicle recycling within Golgi (GO:0000301)5.43861300
33ventricular system development (GO:0021591)5.42633781
34regulation of microtubule-based movement (GO:0060632)5.40845578
35phosphatidylethanolamine metabolic process (GO:0046337)5.37818766
36centriole replication (GO:0007099)5.19469796
37male meiosis I (GO:0007141)5.10467012
38cell recognition (GO:0008037)5.05320079
39chromosome condensation (GO:0030261)4.89065211
40multicellular organismal reproductive process (GO:0048609)4.87231576
41ketone body metabolic process (GO:1902224)4.84032470
42seminiferous tubule development (GO:0072520)4.81769025
43centriole assembly (GO:0098534)4.80008139
44microtubule severing (GO:0051013)4.78425928
45positive regulation of Rab GTPase activity (GO:0032851)4.77221240
46regulation of Rab GTPase activity (GO:0032313)4.77221240
47glycerol ether metabolic process (GO:0006662)4.76773778
48DNA methylation involved in gamete generation (GO:0043046)4.74371072
49DNA packaging (GO:0006323)4.70820586
50chromosome organization involved in meiosis (GO:0070192)4.69968906
51left/right pattern formation (GO:0060972)4.60854583
52* calcium ion-dependent exocytosis (GO:0017156)4.56116816
53ether metabolic process (GO:0018904)4.40471603
54coenzyme catabolic process (GO:0009109)4.33347377
55meiotic nuclear division (GO:0007126)4.28577412
56spermatid nucleus differentiation (GO:0007289)4.25073501
57regulation of centriole replication (GO:0046599)4.22438868
58protein localization to Golgi apparatus (GO:0034067)4.20576372
59meiosis I (GO:0007127)4.08631038
60regulation of transcription involved in cell fate commitment (GO:0060850)4.06365106
61chromatin silencing (GO:0006342)4.03985781
62chaperone-mediated protein complex assembly (GO:0051131)4.03805170
63multicellular organismal development (GO:0007275)3.91557465
64protein polyglutamylation (GO:0018095)3.76383033
65genitalia morphogenesis (GO:0035112)3.75700593
66sequestering of actin monomers (GO:0042989)3.68312255
67histone H3-K9 demethylation (GO:0033169)3.68091924
68glomerular epithelial cell development (GO:0072310)3.65697692
69monoubiquitinated protein deubiquitination (GO:0035520)3.55425422
70protein localization to cilium (GO:0061512)3.55242775
71meiotic cell cycle (GO:0051321)3.49305841
72glomerular visceral epithelial cell development (GO:0072015)3.48174546
73nonmotile primary cilium assembly (GO:0035058)3.48011746
74regulation of spindle checkpoint (GO:0090231)3.39611143
75sexual reproduction (GO:0019953)3.37369219
76protein refolding (GO:0042026)3.36648667
77single strand break repair (GO:0000012)3.35572271
78membrane protein intracellular domain proteolysis (GO:0031293)3.35273043
79response to acidic pH (GO:0010447)3.31927560
80multicellular organismal movement (GO:0050879)3.31924877
81musculoskeletal movement (GO:0050881)3.31924877
82microtubule polymerization or depolymerization (GO:0031109)3.30645675
83amino-acid betaine transport (GO:0015838)3.26734717
84carnitine transport (GO:0015879)3.26734717
85receptor recycling (GO:0001881)3.26114641
86microtubule nucleation (GO:0007020)3.24186369
87cerebral cortex neuron differentiation (GO:0021895)3.19943319
88negative regulation of Rho protein signal transduction (GO:0035024)3.17914105
89RNA localization (GO:0006403)3.16245316
90mesenchymal cell differentiation involved in kidney development (GO:0072161)3.15809887
91mesenchymal cell differentiation involved in renal system development (GO:2001012)3.15809887
92glycolytic process (GO:0006096)3.13165749
93carnitine transmembrane transport (GO:1902603)3.10475731
94mitotic sister chromatid cohesion (GO:0007064)3.08818308
95polyol catabolic process (GO:0046174)3.07737179
96protein K11-linked deubiquitination (GO:0035871)3.07492987
97nucleus organization (GO:0006997)3.06842058
98nucleoside diphosphate phosphorylation (GO:0006165)3.05303512
99RNA destabilization (GO:0050779)3.04710005
100interferon-gamma secretion (GO:0072643)3.03610325
101regulation of phosphoprotein phosphatase activity (GO:0043666)3.02641099
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98322609
103cellular response to pH (GO:0071467)2.97747634
104nucleosome disassembly (GO:0006337)2.96993852
105protein-DNA complex disassembly (GO:0032986)2.96993852
106alditol metabolic process (GO:0019400)2.92243573
107axoneme assembly (GO:0035082)2.91412639
108regulation of T-helper 2 cell differentiation (GO:0045628)2.91273453
109negative regulation of organelle assembly (GO:1902116)2.91166559
110cilium organization (GO:0044782)2.89651884
111microtubule-based movement (GO:0007018)2.89045181
112chemosensory behavior (GO:0007635)2.88741801
113cofactor catabolic process (GO:0051187)2.88639729
114microtubule bundle formation (GO:0001578)2.85763502
115intraciliary transport (GO:0042073)2.84106872
116lactate metabolic process (GO:0006089)2.83512567
117meiotic cell cycle process (GO:1903046)2.81514168
118cilium morphogenesis (GO:0060271)2.79102122
119GTP biosynthetic process (GO:0006183)2.78171626
120synapsis (GO:0007129)2.77874648
121cilium assembly (GO:0042384)2.77320189
122positive regulation of macrophage activation (GO:0043032)2.75022910
123cellular component assembly involved in morphogenesis (GO:0010927)2.73192469
124gene silencing by RNA (GO:0031047)2.70248510
125regulation of cilium assembly (GO:1902017)2.68892397
126peptidyl-glutamic acid modification (GO:0018200)2.67252007
127polyamine biosynthetic process (GO:0006596)2.59377025
128nuclear pore complex assembly (GO:0051292)2.52843385
129UTP biosynthetic process (GO:0006228)2.48129140
130negative regulation of skeletal muscle tissue development (GO:0048642)2.47879787
131sperm motility (GO:0030317)13.9542477
132fusion of sperm to egg plasma membrane (GO:0007342)13.7407560
133cell wall macromolecule catabolic process (GO:0016998)12.0479430
134cell wall macromolecule metabolic process (GO:0044036)12.0479430
135sperm-egg recognition (GO:0035036)11.6619847
136acrosome assembly (GO:0001675)11.4350652
137multicellular organism reproduction (GO:0032504)11.0199614
138binding of sperm to zona pellucida (GO:0007339)10.6320270
139plasma membrane fusion (GO:0045026)10.4662217
140cell-cell recognition (GO:0009988)10.4327437
141* acrosome reaction (GO:0007340)10.4148388
142axonemal dynein complex assembly (GO:0070286)10.1141990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.75554894
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.62624243
3EZH2_22144423_ChIP-Seq_EOC_Human4.41893432
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09973041
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54840928
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.38261461
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99470701
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97267482
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91169563
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75978502
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.45305014
12FUS_26573619_Chip-Seq_HEK293_Human2.43144324
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.36190694
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34415181
15VDR_22108803_ChIP-Seq_LS180_Human2.30939207
16* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27523689
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.06207915
18ZNF274_21170338_ChIP-Seq_K562_Hela2.04590067
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02553028
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01305498
21ERA_21632823_ChIP-Seq_H3396_Human1.91320875
22ER_23166858_ChIP-Seq_MCF-7_Human1.89330594
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.87831694
24RAC3_21632823_ChIP-Seq_H3396_Human1.82973502
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82385007
26MYC_19829295_ChIP-Seq_ESCs_Human1.78960649
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78514947
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77314819
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73929457
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73236825
31SMAD4_21741376_ChIP-Seq_EPCs_Human1.71137474
32STAT1_17558387_ChIP-Seq_HELA_Human1.71035488
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69798946
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69433982
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.63777557
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61807418
37OCT4_20526341_ChIP-Seq_ESCs_Human1.60457965
38TAF2_19829295_ChIP-Seq_ESCs_Human1.59979367
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.59492718
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57627019
41CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.55167548
42HNFA_21074721_ChIP-Seq_CACO-2_Human1.55163832
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54832733
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54551584
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54309966
46* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51474809
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51098632
48RBPJ_21746931_ChIP-Seq_IB4_Human1.50876667
49P300_19829295_ChIP-Seq_ESCs_Human1.50557729
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50204839
51SMC4_20622854_ChIP-Seq_HELA_Human1.49437483
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.48801951
53GATA3_21867929_ChIP-Seq_CD8_Mouse1.48551233
54* AR_25329375_ChIP-Seq_VCAP_Human1.46919525
55CBP_20019798_ChIP-Seq_JUKART_Human1.45240110
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45240110
57PHF8_20622853_ChIP-Seq_HELA_Human1.44378130
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.42487926
59PHF8_20622854_ChIP-Seq_HELA_Human1.42188334
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.42123684
61ETV1_20927104_ChIP-Seq_GIST48_Human1.42050489
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41388688
63FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39884594
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.38627574
65KDM2B_26808549_Chip-Seq_REH_Human1.38354715
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.38256615
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38096832
68BCL6_27268052_Chip-Seq_Bcells_Human1.36187661
69TP63_22573176_ChIP-Seq_HFKS_Human1.35740004
70BCOR_27268052_Chip-Seq_Bcells_Human1.34763542
71P68_20966046_ChIP-Seq_HELA_Human1.34445541
72E2F1_20622854_ChIP-Seq_HELA_Human1.33865668
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33834605
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33738820
75P53_21459846_ChIP-Seq_SAOS-2_Human1.32938269
76CTCF_27219007_Chip-Seq_Bcells_Human1.32398416
77TP53_18474530_ChIP-ChIP_U2OS_Human1.31989333
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28942545
79REST_21632747_ChIP-Seq_MESCs_Mouse1.28847572
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28222807
81KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27767026
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.27721153
83STAT3_23295773_ChIP-Seq_U87_Human1.27623369
84* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25638634
85CEBPB_22108803_ChIP-Seq_LS180_Human1.25575714
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25343573
87P300_27268052_Chip-Seq_Bcells_Human1.23664613
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22804074
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.21845019
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.21603695
91SMAD4_21799915_ChIP-Seq_A2780_Human1.21502225
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.21462032
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.21126091
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20897028
95RUNX2_22187159_ChIP-Seq_PCA_Human1.19748235
96RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18977629
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.18777832
98DROSHA_22980978_ChIP-Seq_HELA_Human1.18360347
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17592423
100SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17299315
101SOX2_19829295_ChIP-Seq_ESCs_Human1.17268360
102NANOG_19829295_ChIP-Seq_ESCs_Human1.17268360
103GF1_26923725_Chip-Seq_HPCs_Mouse1.17165124
104PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17083569
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16994204
106SMRT_27268052_Chip-Seq_Bcells_Human1.14326840
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13832585
108NFYA_21822215_ChIP-Seq_K562_Human1.13574828
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13342372
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13341402
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13097952
112SMAD4_21741376_ChIP-Seq_HESCs_Human1.12794715
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12235667
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12235667
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11959203
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11445162
117HOXB7_26014856_ChIP-Seq_BT474_Human1.11096600
118SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10953477
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10707865
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10028407
121RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09382339
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09294256
123TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.08525804
124ERG_20517297_ChIP-Seq_VCAP_Human1.08336548
125OCT1_27270436_Chip-Seq_PROSTATE_Human1.07751661
126SPI1_26923725_Chip-Seq_HPCs_Mouse1.07642314
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06986529
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06321678
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06056992
130STAT1_20625510_ChIP-Seq_HELA_Human1.05823444
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05736934
132FOXH1_21741376_ChIP-Seq_EPCs_Human1.04986301
133MYC_27129775_Chip-Seq_CORNEA_Mouse1.04752244
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04336878
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04295699
136RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03355636
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.03167316
138* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02226282
139RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02183068
140TAF15_26573619_Chip-Seq_HEK293_Human1.00709470
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.00576960
142RARA_24833708_ChIP-Seq_LIVER_Mouse1.00041746
143CTCF_20526341_ChIP-Seq_ESCs_Human0.99318848
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.98613634
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.98595705
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97955443
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.97562193
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97374205
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.96896387
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96314010
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.94783704
152SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93610606
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93461097
154LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91126491
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90795449
156* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90035339
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89859251
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89823596
159OCT4_18555785_Chip-Seq_ESCs_Mouse0.89530904
160FLI1_21867929_ChIP-Seq_CD8_Mouse0.89106625
161NFYB_21822215_ChIP-Seq_K562_Human0.88816248
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88770396
163P53_22387025_ChIP-Seq_ESCs_Mouse0.88468566
164RNF2_27304074_Chip-Seq_NSC_Mouse0.87692974
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87630200
166SOX9_26525672_Chip-Seq_HEART_Mouse0.86465142
167NANOG_20526341_ChIP-Seq_ESCs_Human0.85169391
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85029186
169* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84917324
170TBL1_22424771_ChIP-Seq_293T_Human0.84580714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03926919
2MP0001929_abnormal_gametogenesis5.46604564
3MP0008877_abnormal_DNA_methylation4.07000423
4MP0002210_abnormal_sex_determination3.34936961
5MP0002161_abnormal_fertility/fecundity3.28960414
6MP0005670_abnormal_white_adipose2.93204879
7MP0001145_abnormal_male_reproductive2.85079766
8MP0001348_abnormal_lacrimal_gland2.53837102
9MP0000653_abnormal_sex_gland2.46515837
10MP0002653_abnormal_ependyma_morphology2.40144288
11MP0003718_maternal_effect2.30352522
12MP0005379_endocrine/exocrine_gland_phen2.03322357
13MP0005310_abnormal_salivary_gland2.01042699
14MP0005410_abnormal_fertilization16.5506681
15MP0000678_abnormal_parathyroid_gland1.92615340
16MP0002160_abnormal_reproductive_system1.78711213
17MP0003646_muscle_fatigue1.68307511
18MP0002132_abnormal_respiratory_system1.67641438
19MP0001485_abnormal_pinna_reflex1.59396443
20MP0001486_abnormal_startle_reflex1.53728596
21MP0005623_abnormal_meninges_morphology1.52848401
22MP0005451_abnormal_body_composition1.41863134
23MP0004233_abnormal_muscle_weight1.41051476
24MP0004510_myositis1.39320092
25MP0002282_abnormal_trachea_morphology1.27160777
26MP0001963_abnormal_hearing_physiology1.25048397
27MP0005248_abnormal_Harderian_gland1.16937530
28MP0008004_abnormal_stomach_pH1.13546391
29MP0002735_abnormal_chemical_nociception1.12685080
30MP0001765_abnormal_ion_homeostasis1.11880436
31MP0005167_abnormal_blood-brain_barrier1.11070945
32MP0009697_abnormal_copulation1.08965379
33MP0002138_abnormal_hepatobiliary_system1.04833896
34MP0002822_catalepsy1.00845239
35MP0001984_abnormal_olfaction1.00496230
36MP0005395_other_phenotype1.00312274
37MP0000026_abnormal_inner_ear0.99573753
38MP0001905_abnormal_dopamine_level0.95651970
39MP0002127_abnormal_cardiovascular_syste0.91818105
40MP0000955_abnormal_spinal_cord0.90985413
41MP0005647_abnormal_sex_gland0.90350781
42MP0009053_abnormal_anal_canal0.89292153
43MP0005389_reproductive_system_phenotype0.89156099
44MP0008995_early_reproductive_senescence0.88963656
45MP0004085_abnormal_heartbeat0.88465687
46MP0001529_abnormal_vocalization0.88186782
47MP0004859_abnormal_synaptic_plasticity0.88022265
48MP0008789_abnormal_olfactory_epithelium0.87744851
49MP0002249_abnormal_larynx_morphology0.84782297
50MP0003115_abnormal_respiratory_system0.81319488
51MP0009046_muscle_twitch0.79506188
52MP0002733_abnormal_thermal_nociception0.78315087
53MP0003136_yellow_coat_color0.76577276
54MP0000049_abnormal_middle_ear0.75252644
55MP0005394_taste/olfaction_phenotype0.75162024
56MP0005499_abnormal_olfactory_system0.75162024
57MP0003878_abnormal_ear_physiology0.75056574
58MP0005377_hearing/vestibular/ear_phenot0.75056574
59MP0008058_abnormal_DNA_repair0.71097516
60MP0000015_abnormal_ear_pigmentation0.70666830
61MP0002067_abnormal_sensory_capabilities0.68749980
62MP0002734_abnormal_mechanical_nocicepti0.67742418
63MP0003011_delayed_dark_adaptation0.67120019
64MP0002572_abnormal_emotion/affect_behav0.66807187
65MP0001666_abnormal_nutrient_absorption0.66473367
66MP0002234_abnormal_pharynx_morphology0.65718569
67MP0005367_renal/urinary_system_phenotyp0.64839035
68MP0000516_abnormal_urinary_system0.64839035
69MP0001970_abnormal_pain_threshold0.64028814
70MP0005666_abnormal_adipose_tissue0.63461056
71MP0005084_abnormal_gallbladder_morpholo0.61211665
72MP0000569_abnormal_digit_pigmentation0.60878021
73MP0002557_abnormal_social/conspecific_i0.60741238
74MP0008569_lethality_at_weaning0.59835628
75MP0005636_abnormal_mineral_homeostasis0.59216501
76MP0003119_abnormal_digestive_system0.57161285
77MP0009745_abnormal_behavioral_response0.56375624
78MP0000681_abnormal_thyroid_gland0.56186827
79MP0003172_abnormal_lysosome_physiology0.55622080
80MP0003077_abnormal_cell_cycle0.54393561
81MP0000003_abnormal_adipose_tissue0.54037447
82MP0000230_abnormal_systemic_arterial0.53948117
83MP0000358_abnormal_cell_content/0.53891006
84MP0003329_amyloid_beta_deposits0.53719325
85MP0009278_abnormal_bone_marrow0.53519031
86MP0002272_abnormal_nervous_system0.52783694
87MP0001324_abnormal_eye_pigmentation0.51407046
88MP0001545_abnormal_hematopoietic_system0.51028333
89MP0005397_hematopoietic_system_phenotyp0.51028333
90MP0010094_abnormal_chromosome_stability0.49537494
91MP0004215_abnormal_myocardial_fiber0.49078700
92MP0000566_synostosis0.48821352
93MP0004036_abnormal_muscle_relaxation0.48472244
94MP0005083_abnormal_biliary_tract0.47323717
95MP0003699_abnormal_female_reproductive0.47286056
96MP0004484_altered_response_of0.46096740
97MP0001764_abnormal_homeostasis0.45470950
98MP0001293_anophthalmia0.45392534
99MP0002269_muscular_atrophy0.44787928
100MP0002254_reproductive_system_inflammat0.44530447
101MP0003950_abnormal_plasma_membrane0.42313207
102MP0002928_abnormal_bile_duct0.42032272
103MP0000534_abnormal_ureter_morphology0.41208346
104MP0006036_abnormal_mitochondrial_physio0.39427419
105MP0009115_abnormal_fat_cell0.38689267
106MP0005253_abnormal_eye_physiology0.37759594
107MP0005551_abnormal_eye_electrophysiolog0.35905679
108MP0003111_abnormal_nucleus_morphology0.33911873
109MP0003786_premature_aging0.32537030
110MP0003942_abnormal_urinary_system0.32473523
111MP0002971_abnormal_brown_adipose0.32230507
112MP0005391_vision/eye_phenotype0.30866458
113MP0003879_abnormal_hair_cell0.30652773
114MP0004811_abnormal_neuron_physiology0.30151902
115MP0002736_abnormal_nociception_after0.29716017
116MP0008961_abnormal_basal_metabolism0.29506272
117MP0000604_amyloidosis0.27478706
118MP0001661_extended_life_span0.27413384
119MP0001730_embryonic_growth_arrest0.26961863
120MP0003633_abnormal_nervous_system0.26752629
121MP0008007_abnormal_cellular_replicative0.26619283
122MP0000751_myopathy0.26469678
123MP0002295_abnormal_pulmonary_circulatio0.26030585
124MP0008057_abnormal_DNA_replication0.25682555
125MP0001727_abnormal_embryo_implantation0.25656366
126MP0003861_abnormal_nervous_system0.24892797
127MP0001119_abnormal_female_reproductive0.24240426
128MP0003948_abnormal_gas_homeostasis0.24056728
129MP0005375_adipose_tissue_phenotype0.23579927
130MP0004133_heterotaxia0.23255010
131MP0002152_abnormal_brain_morphology0.22956552
132MP0006035_abnormal_mitochondrial_morpho0.22146818
133MP0004019_abnormal_vitamin_homeostasis0.22120155
134MP0003631_nervous_system_phenotype0.20622941
135MP0002139_abnormal_hepatobiliary_system0.20425147
136MP0002169_no_abnormal_phenotype0.20031284
137MP0010307_abnormal_tumor_latency0.19874377
138MP0002873_normal_phenotype0.19803722
139MP0002102_abnormal_ear_morphology0.19541694
140MP0003787_abnormal_imprinting0.19026238
141MP0002092_abnormal_eye_morphology0.18824254
142MP0004270_analgesia0.18640785
143MP0004742_abnormal_vestibular_system0.18540440
144MP0004808_abnormal_hematopoietic_stem0.18471099
145MP0001849_ear_inflammation0.17032980
146MP0003045_fibrosis0.16799154
147MP0000313_abnormal_cell_death0.16123293
148MP0003959_abnormal_lean_body0.15847792
149MP0005423_abnormal_somatic_nervous0.15251676
150MP0002084_abnormal_developmental_patter0.14463096
151MP0002229_neurodegeneration0.13737632
152MP0001968_abnormal_touch/_nociception0.13708659
153MP0004043_abnormal_pH_regulation0.13123123
154MP0000001_mammalian_phenotype0.12990676
155MP0004130_abnormal_muscle_cell0.12954303
156MP0001986_abnormal_taste_sensitivity0.12598371
157MP0009672_abnormal_birth_weight0.12230513
158MP0002405_respiratory_system_inflammati0.11690028

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.23769247
2Abnormal respiratory motile cilium morphology (HP:0005938)9.23769247
3Abnormal respiratory motile cilium physiology (HP:0012261)9.21468407
4Rhinitis (HP:0012384)7.50581933
5Abnormal ciliary motility (HP:0012262)7.25588303
6Chronic bronchitis (HP:0004469)7.18350739
7Infertility (HP:0000789)7.00826087
8Nasal polyposis (HP:0100582)6.39182427
9Severe visual impairment (HP:0001141)5.32324252
10Abnormality of the nasal mucosa (HP:0000433)5.25943948
11Male infertility (HP:0003251)4.90808721
12Bronchitis (HP:0012387)4.61851440
13Chronic hepatic failure (HP:0100626)4.52486595
14Bronchiectasis (HP:0002110)4.43207974
15Hyperkalemia (HP:0002153)4.36772501
16Nephronophthisis (HP:0000090)4.33516979
17Cone-rod dystrophy (HP:0000548)4.01010386
18Bony spicule pigmentary retinopathy (HP:0007737)3.83399660
19Attenuation of retinal blood vessels (HP:0007843)3.73693030
20Abnormal spermatogenesis (HP:0008669)3.72290744
21Resting tremor (HP:0002322)3.59002320
22Abnormality of macular pigmentation (HP:0008002)3.57661209
23Progressive sensorineural hearing impairment (HP:0000408)3.41714152
24Recurrent otitis media (HP:0000403)3.32607205
25Recurrent sinusitis (HP:0011108)3.31722985
26Abnormality of the renal medulla (HP:0100957)3.26147418
27Abnormal rod and cone electroretinograms (HP:0008323)2.90923904
28Recurrent bronchitis (HP:0002837)2.90851908
29Impulsivity (HP:0100710)2.88088460
30Tubulointerstitial nephritis (HP:0001970)2.87757043
31Postural instability (HP:0002172)2.74726035
32Aplasia/Hypoplasia of the earlobes (HP:0009906)2.70193322
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.69947408
34Enlarged epiphyses (HP:0010580)2.66102953
35Amelogenesis imperfecta (HP:0000705)2.65935641
36Tubular atrophy (HP:0000092)2.64093023
37Gonadotropin excess (HP:0000837)2.59475097
38Hypoplastic ischia (HP:0003175)2.56550312
39Hypoplasia of the thymus (HP:0000778)2.55967500
40Molar tooth sign on MRI (HP:0002419)2.55396220
41Abnormality of midbrain morphology (HP:0002418)2.55396220
42Abnormality of dental color (HP:0011073)2.55001214
43Potter facies (HP:0002009)2.53839378
44Facial shape deformation (HP:0011334)2.53839378
45Abnormality of chloride homeostasis (HP:0011422)2.52389367
46Tubulointerstitial abnormality (HP:0001969)2.49412093
47Insulin-resistant diabetes mellitus (HP:0000831)2.49018699
48Abnormal gallbladder physiology (HP:0012438)2.48695661
49Cholecystitis (HP:0001082)2.48695661
50Hypoalphalipoproteinemia (HP:0003233)2.37192134
51Pancreatic fibrosis (HP:0100732)2.36452770
52Azoospermia (HP:0000027)2.33849135
53Menstrual irregularities (HP:0000858)2.33598475
54Retinal atrophy (HP:0001105)2.32189261
55Abnormality of potassium homeostasis (HP:0011042)2.31804467
56Medial flaring of the eyebrow (HP:0010747)2.28406893
57Abnormality of the ischium (HP:0003174)2.27372493
58Poor coordination (HP:0002370)2.26533765
59Progressive hearing impairment (HP:0001730)2.26125617
60Dyschromatopsia (HP:0007641)2.20178511
61Occipital encephalocele (HP:0002085)2.17510050
62Generalized aminoaciduria (HP:0002909)2.17098760
63Unilateral renal agenesis (HP:0000122)2.14820155
64Recurrent corneal erosions (HP:0000495)2.12975807
65Spastic tetraparesis (HP:0001285)2.08893064
66Nephrogenic diabetes insipidus (HP:0009806)2.07127870
67Choroideremia (HP:0001139)2.04774498
68Genital tract atresia (HP:0001827)2.03900212
69Tubulointerstitial fibrosis (HP:0005576)2.03864170
70Vaginal atresia (HP:0000148)2.00551937
71Dynein arm defect of respiratory motile cilia (HP:0012255)13.4762953
72Absent/shortened dynein arms (HP:0200106)13.4762953
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9625109
74Hyponatremia (HP:0002902)1.99048128
75Abnormality of the aortic arch (HP:0012303)1.97791479
76Pancreatic cysts (HP:0001737)1.95489484
77Heterotopia (HP:0002282)1.89242773
78True hermaphroditism (HP:0010459)1.88680698
79Portal hypertension (HP:0001409)1.88478958
80Progressive cerebellar ataxia (HP:0002073)1.87261159
81Decreased central vision (HP:0007663)1.86431206
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84113002
83Stage 5 chronic kidney disease (HP:0003774)1.84085098
84Polydipsia (HP:0001959)1.84015211
85Abnormal drinking behavior (HP:0030082)1.84015211
86Flattened epiphyses (HP:0003071)1.82295752
87Postaxial foot polydactyly (HP:0001830)1.82132386
88Abnormality of the lower motor neuron (HP:0002366)1.77717845
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75004478
90Hemorrhage of the eye (HP:0011885)1.72565265
91Scotoma (HP:0000575)1.72362890
92Sclerocornea (HP:0000647)1.71150187
93Sensory axonal neuropathy (HP:0003390)1.71105735
94Intellectual disability, moderate (HP:0002342)1.70381806
95Anencephaly (HP:0002323)1.70302842
96Horizontal nystagmus (HP:0000666)1.70147249
97Male pseudohermaphroditism (HP:0000037)1.69707973
98Congenital sensorineural hearing impairment (HP:0008527)1.69649017
99Abnormality of the costochondral junction (HP:0000919)1.69065011
100Subcapsular cataract (HP:0000523)1.68964261
101Abnormality of the renal cortex (HP:0011035)1.68897378
102Congenital hepatic fibrosis (HP:0002612)1.68728572
103Bell-shaped thorax (HP:0001591)1.67807023
104Abnormality of the hepatic vasculature (HP:0006707)1.67517928
105Epiphyseal dysplasia (HP:0002656)1.66278957
106Abnormality of the parathyroid morphology (HP:0011766)1.66114745
107Abnormality of renal excretion (HP:0011036)1.65889757
108Abnormality of abdominal situs (HP:0011620)1.65557424
109Abdominal situs inversus (HP:0003363)1.65557424
110Osteomalacia (HP:0002749)1.65392259
111Short ribs (HP:0000773)1.65099693
112Oculomotor apraxia (HP:0000657)1.58054071
113Neurofibrillary tangles (HP:0002185)1.56982438
114Abnormal biliary tract physiology (HP:0012439)1.56862495
115Bile duct proliferation (HP:0001408)1.56862495
116Abnormality of dentin (HP:0010299)1.56707724
117Fibular hypoplasia (HP:0003038)1.56215121
118Abnormality of the dental root (HP:0006486)1.50592402
119Taurodontia (HP:0000679)1.50592402
120Abnormality of permanent molar morphology (HP:0011071)1.50592402
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49205159
122Amyotrophic lateral sclerosis (HP:0007354)1.49130007
123Renal dysplasia (HP:0000110)1.48597811
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.44766779
125Absent epiphyses (HP:0010577)1.44766779
126Absent frontal sinuses (HP:0002688)1.42806203
127Abnormality of the dental pulp (HP:0006479)1.42204953
128Deformed sella turcica (HP:0002681)1.41936268
129Asymmetric septal hypertrophy (HP:0001670)1.41682216
130Postaxial hand polydactyly (HP:0001162)1.41076962
131Abnormal urine output (HP:0012590)1.39362747
132Abnormality of molar morphology (HP:0011070)1.38920355
133Abnormality of molar (HP:0011077)1.38920355
134Aplasia/Hypoplasia of the lens (HP:0008063)1.37909886
135Hemiparesis (HP:0001269)1.37574785
136J-shaped sella turcica (HP:0002680)1.33222673
137Impaired proprioception (HP:0010831)1.31892545
138Cerebral inclusion bodies (HP:0100314)1.31339850
139Facial cleft (HP:0002006)1.30813595
140Double outlet right ventricle (HP:0001719)1.30799528
141Congenital malformation of the right heart (HP:0011723)1.30799528
142Cystic liver disease (HP:0006706)1.29687467
143Bundle branch block (HP:0011710)1.28598100
144Broad distal phalanx of finger (HP:0009836)1.28058178
145Chronic sinusitis (HP:0011109)1.26724130
146Nephropathy (HP:0000112)1.23348192
147Microglossia (HP:0000171)1.23336468
148Short thorax (HP:0010306)1.22985751
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22732815
150Loss of speech (HP:0002371)1.20882584
151Easy fatigability (HP:0003388)1.20248433
152Short femoral neck (HP:0100864)1.19986592
153Cerebellar dysplasia (HP:0007033)1.18332445
154Hypercholesterolemia (HP:0003124)1.18061545
155Truncal obesity (HP:0001956)1.15976482
156Polyuria (HP:0000103)1.15517518
157Exercise-induced myalgia (HP:0003738)1.14185244
158Myoglobinuria (HP:0002913)1.13309934
159Pachygyria (HP:0001302)1.11562862
160Congenital primary aphakia (HP:0007707)1.11260980
161Gait imbalance (HP:0002141)1.11149681

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.72209042
2PDK47.72209042
3TESK16.80943531
4PRKD35.78842920
5PDK24.98298466
6ICK4.74158464
7DDR23.74000156
8PLK23.51299633
9MAP4K23.20311387
10INSRR3.15766959
11BRD42.91470674
12PTK2B2.39151190
13PNCK2.24481028
14WNK42.16601833
15STK392.03419201
16MAPKAPK32.00224185
17STK381.91588894
18NEK21.70234137
19DYRK1B1.61058113
20MAP3K41.57021453
21TRPM71.44596548
22MST1R1.40163367
23PIK3CG1.28498936
24MAP3K91.26520114
25PDK11.14746615
26PBK1.03061520
27ADRBK20.98720909
28RPS6KA20.96005664
29TYRO30.95953865
30MAPK110.95704776
31ACVR1B0.94662536
32TNIK0.93747802
33MAPK150.90212737
34DYRK30.89074887
35WNK10.88952835
36ZAK0.84373257
37PRKAA20.82840078
38SIK20.74466127
39PASK0.74307830
40PDPK10.72363009
41CAMK1G0.71921344
42MAP3K20.71629005
43MAP2K70.70273832
44TESK20.69387137
45IRAK10.66603548
46MET0.66052327
47EEF2K0.65634085
48STK30.64931841
49CCNB10.64019184
50CAMK1D0.63253218
51TTK0.60181431
52FRK0.59930458
53RIPK40.59253645
54MAP2K60.56065024
55CHEK20.55112322
56CDK70.54827490
57KSR20.54715204
58RPS6KB20.54243720
59PINK10.52805237
60GRK70.49579815
61OXSR10.47512861
62NTRK30.46481023
63LATS20.43878952
64MAPK130.43784598
65PAK10.43366357
66LMTK20.39781357
67CHEK10.38774026
68IRAK20.38388203
69NTRK20.38294875
70CAMK10.38241780
71MUSK0.35467698
72PAK20.35215584
73MTOR0.33413332
74BMX0.32682308
75SGK4940.31867643
76SGK2230.31867643
77PRKCG0.31684779
78STK38L0.30827505
79FGFR30.30705753
80MAPK10.30474533
81MAP3K100.30329110
82CDK190.29231996
83ATM0.28964530
84PAK40.28708356
85MAP3K80.28375735
86MARK20.27954824
87AKT20.27586375
88MAP3K110.27227352
89NEK60.26889964
90ATR0.26310958
91UHMK10.25748179
92CAMKK10.25653617
93PRKAA10.23040411
94FGFR20.21846713
95WEE10.21349025
96SGK10.21023570
97BMPR1B0.20328808
98AKT30.19607502
99MAPKAPK50.19568623
100MAP2K20.18477322
101RPS6KB10.18172475
102CDC70.16104004
103MAP3K60.15103721
104PRKCZ0.15089849
105MAPK140.14934455
106PLK40.14638901
107ROCK10.14380323
108PLK10.11178516
109PRKCQ0.10393931
110CDK150.10353134
111RPS6KA10.08867118
112CDK180.07921283
113CDK120.07482541
114CSNK1D0.07461937
115GSK3B0.06848443
116CDK11A0.06754533
117CDK60.06460773
118BRAF0.05949671
119BRSK20.05162108
120CSF1R0.04952836
121CSNK2A10.04936068
122CDK140.03660072
123STK110.03581766
124CDK20.03363039
125PRKACG0.02986960
126PRKG20.02926046
127PRKG10.02748601
128CDK10.02608041
129MARK30.02390378
130BRSK10.02323031
131PKN10.02192589
132STK100.02073610
133MAPK80.02002799
134CAMK2A0.01698751
135PAK60.01585962
136PRKCB0.01527524
137CLK10.01484881
138WNK30.01059865
139PIM10.00418433
140EPHB10.00281218
141CDK40.00260713
142CSNK2A20.00075902
143MAP3K1-0.0328336
144PRKACB-0.0299529
145AURKA-0.0265533
146ZAP70-0.0257456
147PRKDC-0.0245578
148RPS6KA3-0.0200661
149PRKCA-0.0135439
150EGFR-0.0087581
151TRIB3-0.0076794
152PRKCD-0.0003590

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.52418627
2Fatty acid biosynthesis_Homo sapiens_hsa000614.58141454
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.43111155
4Vitamin B6 metabolism_Homo sapiens_hsa007503.69436353
5Butanoate metabolism_Homo sapiens_hsa006503.54260585
6Pyruvate metabolism_Homo sapiens_hsa006203.51644983
7Olfactory transduction_Homo sapiens_hsa047403.25223724
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.97321727
9Linoleic acid metabolism_Homo sapiens_hsa005912.85828244
10Propanoate metabolism_Homo sapiens_hsa006402.76618332
11Glucagon signaling pathway_Homo sapiens_hsa049222.63210805
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.58708117
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53508736
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40408608
15Selenocompound metabolism_Homo sapiens_hsa004502.13256436
16Basal transcription factors_Homo sapiens_hsa030222.10874004
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06538042
18Glycerolipid metabolism_Homo sapiens_hsa005612.03859526
19PPAR signaling pathway_Homo sapiens_hsa033201.96944697
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76818301
21Dorso-ventral axis formation_Homo sapiens_hsa043201.72173930
22Oocyte meiosis_Homo sapiens_hsa041141.67944950
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.66558880
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65739168
25Fructose and mannose metabolism_Homo sapiens_hsa000511.65276929
26Phenylalanine metabolism_Homo sapiens_hsa003601.64907724
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.62990451
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.62469920
29Amphetamine addiction_Homo sapiens_hsa050311.59085880
30Pentose phosphate pathway_Homo sapiens_hsa000301.58412757
31Arginine and proline metabolism_Homo sapiens_hsa003301.48179316
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47605606
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.46554753
34Fatty acid metabolism_Homo sapiens_hsa012121.44510882
35Fatty acid degradation_Homo sapiens_hsa000711.41701392
36Mineral absorption_Homo sapiens_hsa049781.39035058
37Fat digestion and absorption_Homo sapiens_hsa049751.38872421
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.36036253
39Fanconi anemia pathway_Homo sapiens_hsa034601.31203449
40Carbon metabolism_Homo sapiens_hsa012001.31047897
41Ether lipid metabolism_Homo sapiens_hsa005651.30784166
42Cardiac muscle contraction_Homo sapiens_hsa042601.27382627
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.24584560
44Renin secretion_Homo sapiens_hsa049241.15693043
45Antigen processing and presentation_Homo sapiens_hsa046121.13751899
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08171282
47mRNA surveillance pathway_Homo sapiens_hsa030151.06892026
48Huntingtons disease_Homo sapiens_hsa050161.01652903
49Type I diabetes mellitus_Homo sapiens_hsa049400.94644175
50Purine metabolism_Homo sapiens_hsa002300.93283621
51RNA transport_Homo sapiens_hsa030130.93120698
52Arginine biosynthesis_Homo sapiens_hsa002200.92879080
53Glutathione metabolism_Homo sapiens_hsa004800.89812419
54Fatty acid elongation_Homo sapiens_hsa000620.88351742
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.87126721
56Peroxisome_Homo sapiens_hsa041460.86437234
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86263568
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85352603
59Hedgehog signaling pathway_Homo sapiens_hsa043400.84795474
60Collecting duct acid secretion_Homo sapiens_hsa049660.84545593
61Regulation of autophagy_Homo sapiens_hsa041400.84208369
62beta-Alanine metabolism_Homo sapiens_hsa004100.81701637
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81064565
64Long-term potentiation_Homo sapiens_hsa047200.80706924
65Insulin secretion_Homo sapiens_hsa049110.79917967
66Phototransduction_Homo sapiens_hsa047440.79614851
67Estrogen signaling pathway_Homo sapiens_hsa049150.77814258
68Biosynthesis of amino acids_Homo sapiens_hsa012300.77225352
69Caffeine metabolism_Homo sapiens_hsa002320.75022344
70Allograft rejection_Homo sapiens_hsa053300.74552630
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71042075
72Arachidonic acid metabolism_Homo sapiens_hsa005900.70784864
73Tryptophan metabolism_Homo sapiens_hsa003800.70222716
74Sphingolipid metabolism_Homo sapiens_hsa006000.70150805
75Bile secretion_Homo sapiens_hsa049760.69892726
76Thyroid hormone synthesis_Homo sapiens_hsa049180.69309562
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68032309
78Autoimmune thyroid disease_Homo sapiens_hsa053200.67667575
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67465559
80Chemical carcinogenesis_Homo sapiens_hsa052040.67350203
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66246755
82Retinol metabolism_Homo sapiens_hsa008300.65757329
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.63871206
84Legionellosis_Homo sapiens_hsa051340.60998877
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60279852
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58787753
87Tyrosine metabolism_Homo sapiens_hsa003500.58701833
88Systemic lupus erythematosus_Homo sapiens_hsa053220.56847001
89Nicotine addiction_Homo sapiens_hsa050330.55757829
90ABC transporters_Homo sapiens_hsa020100.53390915
91Calcium signaling pathway_Homo sapiens_hsa040200.52816179
92Renin-angiotensin system_Homo sapiens_hsa046140.52359591
93Steroid biosynthesis_Homo sapiens_hsa001000.52270040
94AMPK signaling pathway_Homo sapiens_hsa041520.50952876
95Endocytosis_Homo sapiens_hsa041440.48786763
96Lysine degradation_Homo sapiens_hsa003100.48065083
97Synaptic vesicle cycle_Homo sapiens_hsa047210.46648066
98Pancreatic secretion_Homo sapiens_hsa049720.45877968
99Salivary secretion_Homo sapiens_hsa049700.45725938
100Protein digestion and absorption_Homo sapiens_hsa049740.45572087
101Viral myocarditis_Homo sapiens_hsa054160.44597627
102Graft-versus-host disease_Homo sapiens_hsa053320.42827231
103Morphine addiction_Homo sapiens_hsa050320.42154483
104VEGF signaling pathway_Homo sapiens_hsa043700.41339938
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41265753
106Influenza A_Homo sapiens_hsa051640.40995070
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.40377179
108Inositol phosphate metabolism_Homo sapiens_hsa005620.39862031
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39307745
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38614222
111Taste transduction_Homo sapiens_hsa047420.38278471
112Base excision repair_Homo sapiens_hsa034100.37777705
113Gastric acid secretion_Homo sapiens_hsa049710.37625066
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36644197
115Vitamin digestion and absorption_Homo sapiens_hsa049770.35009117
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34834364
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34765761
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34759261
119Non-homologous end-joining_Homo sapiens_hsa034500.34182688
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33141291
121cAMP signaling pathway_Homo sapiens_hsa040240.33089403
122Alcoholism_Homo sapiens_hsa050340.32987605
123Circadian entrainment_Homo sapiens_hsa047130.32512598
124Metabolic pathways_Homo sapiens_hsa011000.32449859
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26097288
126Cocaine addiction_Homo sapiens_hsa050300.25494249
127GABAergic synapse_Homo sapiens_hsa047270.24870880
128Sulfur metabolism_Homo sapiens_hsa009200.22661715
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20619745
130Pyrimidine metabolism_Homo sapiens_hsa002400.17696169
131B cell receptor signaling pathway_Homo sapiens_hsa046620.15954512
132N-Glycan biosynthesis_Homo sapiens_hsa005100.15249192
133Type II diabetes mellitus_Homo sapiens_hsa049300.11636176
134Insulin resistance_Homo sapiens_hsa049310.11136697
135HIF-1 signaling pathway_Homo sapiens_hsa040660.10850985
136Basal cell carcinoma_Homo sapiens_hsa052170.09312808
137Viral carcinogenesis_Homo sapiens_hsa052030.08960244

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