AKAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.98018489
2axonemal dynein complex assembly (GO:0070286)9.96443449
3reproduction (GO:0000003)9.81720664
4regulation of cilium movement (GO:0003352)9.22867506
5motile cilium assembly (GO:0044458)9.19563584
6protein targeting to Golgi (GO:0000042)9.11790099
7establishment of protein localization to Golgi (GO:0072600)8.73015500
8retrograde transport, vesicle recycling within Golgi (GO:0000301)8.52649721
9cilium movement (GO:0003341)8.27165100
10rRNA methylation (GO:0031167)7.76828397
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.57407761
12sperm capacitation (GO:0048240)7.47393762
13* single fertilization (GO:0007338)7.23696137
14negative regulation of inclusion body assembly (GO:0090084)7.15910735
15male meiosis (GO:0007140)7.00026313
16piRNA metabolic process (GO:0034587)6.93664377
17synaptonemal complex organization (GO:0070193)6.89948762
18centriole replication (GO:0007099)6.86087692
19spermatogenesis (GO:0007283)6.72684124
20male gamete generation (GO:0048232)6.70239595
21synaptonemal complex assembly (GO:0007130)6.63313263
22microtubule depolymerization (GO:0007019)6.61943024
23rRNA modification (GO:0000154)6.57549519
24protein localization to Golgi apparatus (GO:0034067)6.56870118
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.53514760
26organic cation transport (GO:0015695)6.48823784
27* fertilization (GO:0009566)6.21906197
28response to pheromone (GO:0019236)6.21754635
29gamete generation (GO:0007276)6.15973898
30centriole assembly (GO:0098534)6.06865911
31phosphatidylethanolamine metabolic process (GO:0046337)6.03900189
32regulation of centriole replication (GO:0046599)6.02248063
33regulation of inclusion body assembly (GO:0090083)5.94600802
34calcium ion-dependent exocytosis (GO:0017156)5.64118362
35germ cell development (GO:0007281)5.52010728
36regulation of microtubule-based movement (GO:0060632)5.48594875
37ventricular system development (GO:0021591)5.46122812
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.43086825
39glomerular visceral epithelial cell development (GO:0072015)5.35908028
40glycerol ether metabolic process (GO:0006662)5.30561681
41cell recognition (GO:0008037)4.99995888
42glomerular epithelial cell development (GO:0072310)4.99292618
43male meiosis I (GO:0007141)4.97775621
44ether metabolic process (GO:0018904)4.90393556
45spermatid nucleus differentiation (GO:0007289)4.90098521
46multicellular organismal reproductive process (GO:0048609)4.87907012
47chromosome condensation (GO:0030261)4.84980819
48microtubule nucleation (GO:0007020)4.66917126
49regulation of Rab GTPase activity (GO:0032313)4.60926718
50positive regulation of Rab GTPase activity (GO:0032851)4.60926718
51DNA packaging (GO:0006323)4.56676020
52chromosome organization involved in meiosis (GO:0070192)4.54036482
53microtubule severing (GO:0051013)4.46378828
54seminiferous tubule development (GO:0072520)4.45447985
55DNA methylation involved in gamete generation (GO:0043046)4.40440884
56left/right pattern formation (GO:0060972)4.37606909
57musculoskeletal movement (GO:0050881)4.33650874
58multicellular organismal movement (GO:0050879)4.33650874
59cellular ketone body metabolic process (GO:0046950)4.30684713
60sexual reproduction (GO:0019953)4.26115085
61meiotic nuclear division (GO:0007126)4.16828956
62chaperone-mediated protein complex assembly (GO:0051131)4.04692567
63chromatin silencing (GO:0006342)4.03005885
64single strand break repair (GO:0000012)3.99829690
65meiosis I (GO:0007127)3.96900742
66multicellular organismal development (GO:0007275)3.91256253
67regulation of transcription involved in cell fate commitment (GO:0060850)3.84746638
68genitalia morphogenesis (GO:0035112)3.80073605
69ketone body metabolic process (GO:1902224)3.79062628
70membrane protein intracellular domain proteolysis (GO:0031293)3.61705955
71intra-Golgi vesicle-mediated transport (GO:0006891)3.56408983
72monoubiquitinated protein deubiquitination (GO:0035520)3.54854606
73protein refolding (GO:0042026)3.52986287
74glycolytic process (GO:0006096)3.51418945
75protein polyglutamylation (GO:0018095)3.49320329
76pore complex assembly (GO:0046931)3.46113280
77nuclear pore organization (GO:0006999)3.41548014
78microtubule polymerization or depolymerization (GO:0031109)3.40768314
79meiotic cell cycle (GO:0051321)3.27768375
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26395805
81protein depolymerization (GO:0051261)3.20871162
82regulation of spindle checkpoint (GO:0090231)3.19239681
83nucleosome disassembly (GO:0006337)3.18612983
84protein-DNA complex disassembly (GO:0032986)3.18612983
85nucleus organization (GO:0006997)3.18179192
86nucleoside diphosphate phosphorylation (GO:0006165)3.11736385
87protein K11-linked deubiquitination (GO:0035871)3.11524758
88protein localization to cilium (GO:0061512)3.08474322
89homeostasis of number of cells within a tissue (GO:0048873)3.07765272
90amino-acid betaine transport (GO:0015838)3.07737433
91carnitine transport (GO:0015879)3.07737433
92polyol catabolic process (GO:0046174)3.07362821
93receptor recycling (GO:0001881)3.06710192
94mitotic sister chromatid cohesion (GO:0007064)3.02666536
95regulation of interleukin-13 production (GO:0032656)3.01647981
96cellular response to pH (GO:0071467)3.00175225
97sequestering of actin monomers (GO:0042989)2.98815296
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98679863
99negative regulation of Rho protein signal transduction (GO:0035024)2.98338883
100alditol metabolic process (GO:0019400)2.97561609
101positive regulation of guanylate cyclase activity (GO:0031284)2.94179103
102histone H3-K9 demethylation (GO:0033169)2.92905947
103lactate metabolic process (GO:0006089)2.92889816
104response to acidic pH (GO:0010447)2.90970138
105DNA conformation change (GO:0071103)2.89881451
106GTP biosynthetic process (GO:0006183)2.89588714
107carnitine transmembrane transport (GO:1902603)2.88196790
108cilium organization (GO:0044782)2.85519639
109microtubule-based movement (GO:0007018)2.84850041
110centrosome duplication (GO:0051298)2.84478632
111vesicle transport along microtubule (GO:0047496)2.84334013
112Golgi to endosome transport (GO:0006895)2.82464289
113RNA localization (GO:0006403)2.80897016
114RNA methylation (GO:0001510)2.80173506
115mitotic G1 DNA damage checkpoint (GO:0031571)2.77503432
116cilium assembly (GO:0042384)2.73557969
117meiotic cell cycle process (GO:1903046)2.72498407
118negative regulation of organelle assembly (GO:1902116)2.71754141
119polyamine biosynthetic process (GO:0006596)2.70491290
120positive regulation of glycolytic process (GO:0045821)2.69513541
121synapsis (GO:0007129)2.69478291
122RNA destabilization (GO:0050779)2.69179077
123cellular component assembly involved in morphogenesis (GO:0010927)2.65589174
124regulation of cilium assembly (GO:1902017)2.64115788
125intraciliary transport (GO:0042073)2.62683342
126interferon-gamma secretion (GO:0072643)2.61535402
127UTP biosynthetic process (GO:0006228)2.59873110
128axoneme assembly (GO:0035082)2.57216081
129cilium morphogenesis (GO:0060271)2.55948329
130nuclear pore complex assembly (GO:0051292)2.53883592
131gene silencing by RNA (GO:0031047)2.51478020
132regulation of protein kinase C signaling (GO:0090036)2.50682318
133negative regulation of skeletal muscle tissue development (GO:0048642)2.48888049
134* sperm motility (GO:0030317)14.1802932
135fusion of sperm to egg plasma membrane (GO:0007342)14.0841602
136acrosome reaction (GO:0007340)12.2732768
137cell wall macromolecule metabolic process (GO:0044036)11.9094254
138cell wall macromolecule catabolic process (GO:0016998)11.9094254
139sperm-egg recognition (GO:0035036)11.5332168
140multicellular organism reproduction (GO:0032504)11.4046511
141acrosome assembly (GO:0001675)11.0577213
142plasma membrane fusion (GO:0045026)10.7429123
143binding of sperm to zona pellucida (GO:0007339)10.4210417
144cell-cell recognition (GO:0009988)10.3229217
145epithelial cilium movement (GO:0003351)10.1992047
146cilium or flagellum-dependent cell motility (GO:0001539)10.1251487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.02212297
2EZH2_22144423_ChIP-Seq_EOC_Human4.40533411
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04051957
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97224087
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.56702646
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.50875301
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42382511
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80061741
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65393405
10VDR_22108803_ChIP-Seq_LS180_Human2.60210135
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52626835
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27504333
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22052147
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20452626
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08793661
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03014261
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.99937956
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99595598
19* FUS_26573619_Chip-Seq_HEK293_Human1.97561159
20RAC3_21632823_ChIP-Seq_H3396_Human1.94658392
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.91224368
22ZNF274_21170338_ChIP-Seq_K562_Hela1.90605126
23DROSHA_22980978_ChIP-Seq_HELA_Human1.89747711
24ERA_21632823_ChIP-Seq_H3396_Human1.80740511
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77755015
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.75858382
27STAT1_17558387_ChIP-Seq_HELA_Human1.72844333
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72577464
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72428156
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72183695
31ER_23166858_ChIP-Seq_MCF-7_Human1.70197024
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68006976
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66827543
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.66368093
35MYC_19829295_ChIP-Seq_ESCs_Human1.64317142
36CBX2_22325352_ChIP-Seq_293T-Rex_Human1.62818646
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.60918873
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60385693
39CTCF_27219007_Chip-Seq_Bcells_Human1.60319793
40TAF2_19829295_ChIP-Seq_ESCs_Human1.58474694
41RBPJ_21746931_ChIP-Seq_IB4_Human1.58101894
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57478088
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56576828
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56514697
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.56041502
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56022663
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54679388
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54416922
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.52490288
50CBP_20019798_ChIP-Seq_JUKART_Human1.52102256
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52102256
52KDM2B_26808549_Chip-Seq_REH_Human1.50445309
53ETV1_20927104_ChIP-Seq_GIST48_Human1.49795852
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.47563751
55TAF15_26573619_Chip-Seq_HEK293_Human1.46735456
56TAL1_26923725_Chip-Seq_HPCs_Mouse1.46574256
57AR_25329375_ChIP-Seq_VCAP_Human1.46112360
58TP53_18474530_ChIP-ChIP_U2OS_Human1.44578493
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43743294
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43692344
61P300_19829295_ChIP-Seq_ESCs_Human1.43350655
62BCL6_27268052_Chip-Seq_Bcells_Human1.42093554
63OCT4_20526341_ChIP-Seq_ESCs_Human1.41652846
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.41160103
65SMC4_20622854_ChIP-Seq_HELA_Human1.40968268
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.40768794
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38693879
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38052518
69TP63_22573176_ChIP-Seq_HFKS_Human1.37255411
70BCOR_27268052_Chip-Seq_Bcells_Human1.33987012
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.33969751
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33176678
73CEBPB_22108803_ChIP-Seq_LS180_Human1.32815092
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32800125
75PHF8_20622853_ChIP-Seq_HELA_Human1.32639653
76FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32553024
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.32355553
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31255035
79REST_21632747_ChIP-Seq_MESCs_Mouse1.31072773
80P53_21459846_ChIP-Seq_SAOS-2_Human1.30755215
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.30567015
82P68_20966046_ChIP-Seq_HELA_Human1.28912236
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.28808355
84PHF8_20622854_ChIP-Seq_HELA_Human1.27361179
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.26891730
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.26223671
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25580532
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.25571548
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25006223
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24549239
91E2F1_20622854_ChIP-Seq_HELA_Human1.24357941
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23924457
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23187210
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22104862
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.21913124
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21325651
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21325651
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20207363
99GF1_26923725_Chip-Seq_HPCs_Mouse1.19853052
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.19582770
101GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19293038
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19209652
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18794837
104SMAD4_21799915_ChIP-Seq_A2780_Human1.17881630
105STAT3_23295773_ChIP-Seq_U87_Human1.17765762
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17027502
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16878841
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16395684
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15740961
110NFYA_21822215_ChIP-Seq_K562_Human1.15284569
111CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15213961
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15062897
113P300_27268052_Chip-Seq_Bcells_Human1.15012694
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14317020
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14228074
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14110292
117P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.11713816
118ERG_20517297_ChIP-Seq_VCAP_Human1.11593397
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.11267167
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10895992
121RUNX2_22187159_ChIP-Seq_PCA_Human1.10292322
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10130183
123SPI1_26923725_Chip-Seq_HPCs_Mouse1.07914545
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.07641858
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07622775
126* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07422375
127LXR_22292898_ChIP-Seq_THP-1_Human1.07207028
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.07191190
129TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06789992
130SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06566272
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05282255
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05023872
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04733426
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.04358480
135SA1_27219007_Chip-Seq_Bcells_Human1.04112731
136NANOG_19829295_ChIP-Seq_ESCs_Human1.04056684
137SOX2_19829295_ChIP-Seq_ESCs_Human1.04056684
138RUNX_20019798_ChIP-Seq_JUKART_Human1.03310076
139SMRT_27268052_Chip-Seq_Bcells_Human1.02880939
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02221594
141MYC_27129775_Chip-Seq_CORNEA_Mouse1.02053226
142E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01821457
143NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01303073
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00025752
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99402416
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.98255753
147JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97791790
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97159204
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96577129
150NFYB_21822215_ChIP-Seq_K562_Human0.95977924
151OCT4_18555785_Chip-Seq_ESCs_Mouse0.95832149
152P53_22387025_ChIP-Seq_ESCs_Mouse0.95740184
153GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95236419
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.95143061
155RNF2_27304074_Chip-Seq_NSC_Mouse0.94264935
156CTCF_20526341_ChIP-Seq_ESCs_Human0.93596474
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.92469097
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92294394
159RARA_24833708_ChIP-Seq_LIVER_Mouse0.92164227
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.91612243
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91279600
162TBL1_22424771_ChIP-Seq_293T_Human0.91192353
163SOX9_26525672_Chip-Seq_HEART_Mouse0.91175631
164NANOG_20526341_ChIP-Seq_ESCs_Human0.90333122
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90283539
166KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89746109
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89369627
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89340066
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88968167
170OCT1_27270436_Chip-Seq_PROSTATE_Human0.88215079
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87793559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.03484716
2* MP0001929_abnormal_gametogenesis5.36244975
3MP0008877_abnormal_DNA_methylation4.04540488
4MP0002210_abnormal_sex_determination3.33840294
5* MP0002161_abnormal_fertility/fecundity3.30169878
6MP0005670_abnormal_white_adipose3.04520904
7MP0001145_abnormal_male_reproductive2.81563197
8MP0000653_abnormal_sex_gland2.43190222
9MP0002653_abnormal_ependyma_morphology2.38523083
10MP0005451_abnormal_body_composition2.26607844
11MP0003718_maternal_effect2.17334999
12MP0001485_abnormal_pinna_reflex2.03973872
13MP0005410_abnormal_fertilization16.6336913
14MP0005379_endocrine/exocrine_gland_phen1.90952179
15MP0005310_abnormal_salivary_gland1.78719752
16MP0000678_abnormal_parathyroid_gland1.76071203
17MP0001486_abnormal_startle_reflex1.73148134
18MP0005623_abnormal_meninges_morphology1.66180714
19MP0002132_abnormal_respiratory_system1.55797730
20MP0002160_abnormal_reproductive_system1.49672270
21MP0002282_abnormal_trachea_morphology1.42247261
22MP0001765_abnormal_ion_homeostasis1.31352896
23MP0003646_muscle_fatigue1.31342484
24MP0004233_abnormal_muscle_weight1.26061487
25MP0004859_abnormal_synaptic_plasticity1.24331574
26MP0001963_abnormal_hearing_physiology1.21246270
27MP0002138_abnormal_hepatobiliary_system1.17547568
28MP0009053_abnormal_anal_canal1.10608972
29MP0008995_early_reproductive_senescence1.06373179
30MP0002249_abnormal_larynx_morphology1.06371206
31MP0004510_myositis0.99730215
32MP0005647_abnormal_sex_gland0.97277150
33MP0005395_other_phenotype0.95896450
34MP0009697_abnormal_copulation0.94659378
35MP0000026_abnormal_inner_ear0.93817696
36MP0001984_abnormal_olfaction0.91626185
37MP0002735_abnormal_chemical_nociception0.90487167
38MP0005248_abnormal_Harderian_gland0.88189786
39MP0002127_abnormal_cardiovascular_syste0.86213683
40MP0003878_abnormal_ear_physiology0.84234804
41MP0005377_hearing/vestibular/ear_phenot0.84234804
42MP0005083_abnormal_biliary_tract0.81104351
43MP0003115_abnormal_respiratory_system0.80537188
44MP0009046_muscle_twitch0.79034256
45MP0005167_abnormal_blood-brain_barrier0.77965362
46MP0000955_abnormal_spinal_cord0.76781913
47MP0002067_abnormal_sensory_capabilities0.75514637
48MP0005389_reproductive_system_phenotype0.73847947
49MP0005636_abnormal_mineral_homeostasis0.72362472
50MP0002822_catalepsy0.69688445
51MP0008058_abnormal_DNA_repair0.69509960
52MP0005666_abnormal_adipose_tissue0.68025783
53MP0002557_abnormal_social/conspecific_i0.65557718
54MP0004085_abnormal_heartbeat0.63781620
55MP0000569_abnormal_digit_pigmentation0.59894535
56MP0003077_abnormal_cell_cycle0.57869437
57MP0002234_abnormal_pharynx_morphology0.57825185
58MP0000230_abnormal_systemic_arterial0.57520203
59MP0002572_abnormal_emotion/affect_behav0.56754173
60MP0003329_amyloid_beta_deposits0.55749679
61MP0010329_abnormal_lipoprotein_level0.55211985
62MP0003011_delayed_dark_adaptation0.54271764
63MP0001905_abnormal_dopamine_level0.54193917
64MP0004084_abnormal_cardiac_muscle0.54028385
65MP0001764_abnormal_homeostasis0.53797636
66MP0002733_abnormal_thermal_nociception0.53534676
67MP0001324_abnormal_eye_pigmentation0.52126781
68MP0005408_hypopigmentation0.51568515
69MP0003137_abnormal_impulse_conducting0.49475909
70MP0004036_abnormal_muscle_relaxation0.49433655
71MP0000681_abnormal_thyroid_gland0.49162051
72MP0005084_abnormal_gallbladder_morpholo0.49130976
73MP0000358_abnormal_cell_content/0.48050401
74MP0003699_abnormal_female_reproductive0.47531207
75MP0001666_abnormal_nutrient_absorption0.47481499
76MP0003950_abnormal_plasma_membrane0.45700288
77MP0005535_abnormal_body_temperature0.45548307
78MP0001293_anophthalmia0.45466744
79MP0002269_muscular_atrophy0.44777660
80MP0005332_abnormal_amino_acid0.44585888
81MP0001501_abnormal_sleep_pattern0.43534496
82MP0000049_abnormal_middle_ear0.43513398
83MP0002272_abnormal_nervous_system0.43512797
84MP0002928_abnormal_bile_duct0.43035933
85MP0000516_abnormal_urinary_system0.41831519
86MP0005367_renal/urinary_system_phenotyp0.41831519
87MP0000003_abnormal_adipose_tissue0.41495509
88MP0009115_abnormal_fat_cell0.41334532
89MP0000534_abnormal_ureter_morphology0.40636239
90MP0001545_abnormal_hematopoietic_system0.40237573
91MP0005397_hematopoietic_system_phenotyp0.40237573
92MP0009745_abnormal_behavioral_response0.40096577
93MP0002736_abnormal_nociception_after0.39970369
94MP0009278_abnormal_bone_marrow0.39942437
95MP0010094_abnormal_chromosome_stability0.39881204
96MP0004782_abnormal_surfactant_physiolog0.39822720
97MP0005253_abnormal_eye_physiology0.38820825
98MP0005595_abnormal_vascular_smooth0.38222915
99MP0005551_abnormal_eye_electrophysiolog0.37343184
100MP0005645_abnormal_hypothalamus_physiol0.36739506
101MP0002971_abnormal_brown_adipose0.36552231
102MP0001270_distended_abdomen0.36245737
103MP0002734_abnormal_mechanical_nocicepti0.35915699
104MP0001879_abnormal_lymphatic_vessel0.35863243
105MP0004484_altered_response_of0.35613673
106MP0001970_abnormal_pain_threshold0.34469692
107MP0003879_abnormal_hair_cell0.33643635
108MP0002139_abnormal_hepatobiliary_system0.33160558
109MP0003942_abnormal_urinary_system0.31859416
110MP0005391_vision/eye_phenotype0.30740727
111MP0003786_premature_aging0.29725994
112MP0000604_amyloidosis0.29239123
113MP0008961_abnormal_basal_metabolism0.28843882
114MP0003633_abnormal_nervous_system0.28733483
115MP0006036_abnormal_mitochondrial_physio0.27671552
116MP0002295_abnormal_pulmonary_circulatio0.27391065
117MP0004270_analgesia0.26858154
118MP0003111_abnormal_nucleus_morphology0.26802129
119MP0000751_myopathy0.26493612
120MP0004811_abnormal_neuron_physiology0.26269361
121MP0001727_abnormal_embryo_implantation0.25954015
122MP0001119_abnormal_female_reproductive0.25695155
123MP0004742_abnormal_vestibular_system0.25655827
124MP0005375_adipose_tissue_phenotype0.25345114
125MP0001968_abnormal_touch/_nociception0.23041997
126MP0004019_abnormal_vitamin_homeostasis0.22823222
127MP0003948_abnormal_gas_homeostasis0.22349899
128MP0003631_nervous_system_phenotype0.21468703
129MP0001849_ear_inflammation0.21379146
130MP0003861_abnormal_nervous_system0.21364814
131MP0002152_abnormal_brain_morphology0.20814538
132MP0001730_embryonic_growth_arrest0.20672383
133MP0004133_heterotaxia0.20440091
134MP0002169_no_abnormal_phenotype0.19824269
135MP0002873_normal_phenotype0.19604460
136MP0009672_abnormal_birth_weight0.18040319
137MP0005365_abnormal_bile_salt0.17768712
138MP0002092_abnormal_eye_morphology0.17649185
139MP0002102_abnormal_ear_morphology0.17322628
140MP0008875_abnormal_xenobiotic_pharmacok0.17163931
141MP0005423_abnormal_somatic_nervous0.17154437
142MP0004043_abnormal_pH_regulation0.17124971
143MP0004145_abnormal_muscle_electrophysio0.15984882
144MP0006035_abnormal_mitochondrial_morpho0.15974979
145MP0002118_abnormal_lipid_homeostasis0.15942719
146MP0003045_fibrosis0.15254433
147MP0002229_neurodegeneration0.14416205
148MP0008569_lethality_at_weaning0.14278231
149MP0002693_abnormal_pancreas_physiology0.14239936
150MP0005319_abnormal_enzyme/_coenzyme0.13924547
151MP0008007_abnormal_cellular_replicative0.13883493
152MP0003959_abnormal_lean_body0.13542922
153MP0001661_extended_life_span0.13449190
154MP0001348_abnormal_lacrimal_gland0.13376918
155MP0000920_abnormal_myelination0.13175816
156MP0001440_abnormal_grooming_behavior0.12680238

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.39845133
2Abnormal respiratory epithelium morphology (HP:0012253)9.39845133
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19441880
4Abnormal ciliary motility (HP:0012262)7.46673998
5Rhinitis (HP:0012384)7.20300117
6Severe visual impairment (HP:0001141)7.04722578
7Chronic bronchitis (HP:0004469)6.97492034
8Infertility (HP:0000789)6.94298374
9Chronic hepatic failure (HP:0100626)6.80890516
10Nasal polyposis (HP:0100582)6.28978733
11Male infertility (HP:0003251)5.38536353
12Abnormality of the nasal mucosa (HP:0000433)5.18183118
13Cone-rod dystrophy (HP:0000548)5.05256625
14Hyperkalemia (HP:0002153)4.58775494
15Resting tremor (HP:0002322)4.57038820
16Bronchitis (HP:0012387)4.56437277
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.44979896
18Hypoalphalipoproteinemia (HP:0003233)4.38814561
19Abnormality of macular pigmentation (HP:0008002)4.36678788
20Bronchiectasis (HP:0002110)4.31728795
21Attenuation of retinal blood vessels (HP:0007843)4.31251087
22Bony spicule pigmentary retinopathy (HP:0007737)4.29498653
23Menstrual irregularities (HP:0000858)4.24217177
24Nephronophthisis (HP:0000090)4.20957834
25Progressive sensorineural hearing impairment (HP:0000408)4.13784441
26Abnormal spermatogenesis (HP:0008669)3.87277082
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.79295426
28Amelogenesis imperfecta (HP:0000705)3.76796032
29Hypoplasia of the thymus (HP:0000778)3.74721497
30Renovascular hypertension (HP:0100817)3.68667931
31Abnormality of dental color (HP:0011073)3.54113569
32Recurrent sinusitis (HP:0011108)3.50032607
33Insulin-resistant diabetes mellitus (HP:0000831)3.38091859
34Recurrent otitis media (HP:0000403)3.27517492
35Facial shape deformation (HP:0011334)3.22028467
36Potter facies (HP:0002009)3.22028467
37Progressive cerebellar ataxia (HP:0002073)3.18752380
38Abnormality of the renal medulla (HP:0100957)3.18321076
39Portal hypertension (HP:0001409)3.18077989
40Postural instability (HP:0002172)3.17227955
41Tubulointerstitial nephritis (HP:0001970)3.00603112
42Recurrent bronchitis (HP:0002837)2.95734106
43Abnormality of the hepatic vasculature (HP:0006707)2.93086666
44Abnormal rod and cone electroretinograms (HP:0008323)2.82219337
45Subcapsular cataract (HP:0000523)2.82047280
46Increased purine levels (HP:0004368)2.78064385
47Hyperuricemia (HP:0002149)2.78064385
48Impulsivity (HP:0100710)2.76470112
49Enlarged epiphyses (HP:0010580)2.75018694
50Progressive hearing impairment (HP:0001730)2.68347781
51Focal segmental glomerulosclerosis (HP:0000097)2.66023971
52Tubular atrophy (HP:0000092)2.65883249
53Cholecystitis (HP:0001082)2.54803074
54Abnormal gallbladder physiology (HP:0012438)2.54803074
55Intellectual disability, moderate (HP:0002342)2.50382141
56Molar tooth sign on MRI (HP:0002419)2.49471086
57Abnormality of midbrain morphology (HP:0002418)2.49471086
58Tubulointerstitial abnormality (HP:0001969)2.49226906
59Gonadotropin excess (HP:0000837)2.46089439
60Abnormality of the costochondral junction (HP:0000919)2.44587526
61Abnormality of potassium homeostasis (HP:0011042)2.43967345
62Hypoplastic ischia (HP:0003175)2.43560214
63Generalized aminoaciduria (HP:0002909)2.36164307
64Osteomalacia (HP:0002749)2.31609360
65Hypolipoproteinemia (HP:0010981)2.27444943
66Myokymia (HP:0002411)2.26709037
67Ventricular tachycardia (HP:0004756)2.25303646
68Azoospermia (HP:0000027)2.24506206
69Dyschromatopsia (HP:0007641)2.22545708
70Abnormality of the ischium (HP:0003174)2.21921484
71Medial flaring of the eyebrow (HP:0010747)2.19541180
72Glomerulosclerosis (HP:0000096)2.13999691
73Spastic tetraparesis (HP:0001285)2.10854815
74Abnormal albumin level (HP:0012116)2.09325604
75Hypoalbuminemia (HP:0003073)2.09325604
76Abnormality of the aortic arch (HP:0012303)2.07140121
77Recurrent pneumonia (HP:0006532)2.02951057
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.9158589
79Absent/shortened dynein arms (HP:0200106)13.9158589
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6913145
81Choroideremia (HP:0001139)1.99228962
82Polyuria (HP:0000103)1.99124392
83Decreased central vision (HP:0007663)1.96735335
84Tubulointerstitial fibrosis (HP:0005576)1.95238719
85Insulin resistance (HP:0000855)1.95167739
86Hypophosphatemic rickets (HP:0004912)1.94513024
87Abnormality of purine metabolism (HP:0004352)1.91511120
88Unilateral renal agenesis (HP:0000122)1.91464542
89Heterotopia (HP:0002282)1.91275832
90Flattened epiphyses (HP:0003071)1.89281474
91Optic nerve hypoplasia (HP:0000609)1.88420692
92Sandal gap (HP:0001852)1.86904462
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82997264
94Gingivitis (HP:0000230)1.82452520
95Widely patent fontanelles and sutures (HP:0004492)1.81427408
96Bradycardia (HP:0001662)1.81295050
97Renal Fanconi syndrome (HP:0001994)1.79402512
98Hyponatremia (HP:0002902)1.78300585
99Hemorrhage of the eye (HP:0011885)1.78001188
100Stage 5 chronic kidney disease (HP:0003774)1.77504886
101Upper limb muscle weakness (HP:0003484)1.77264930
102Abnormal biliary tract physiology (HP:0012439)1.77147136
103Bile duct proliferation (HP:0001408)1.77147136
104Postaxial foot polydactyly (HP:0001830)1.75381443
105Abnormal drinking behavior (HP:0030082)1.75263165
106Polydipsia (HP:0001959)1.75263165
107Acanthosis nigricans (HP:0000956)1.74543449
108Photophobia (HP:0000613)1.72555766
109Obsessive-compulsive behavior (HP:0000722)1.71651183
110Asymmetric septal hypertrophy (HP:0001670)1.70339869
111Congenital sensorineural hearing impairment (HP:0008527)1.70137193
112Bell-shaped thorax (HP:0001591)1.67854671
113Abnormality of the renal cortex (HP:0011035)1.67775061
114Glycosuria (HP:0003076)1.64727866
115Abnormality of renal excretion (HP:0011036)1.63588927
116Congenital hepatic fibrosis (HP:0002612)1.62782580
117Abnormality of the lower motor neuron (HP:0002366)1.61570647
118Short ribs (HP:0000773)1.60620226
119Oculomotor apraxia (HP:0000657)1.53137492
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52695764
121Neurofibrillary tangles (HP:0002185)1.51340817
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50311525
123Abnormality of dentin (HP:0010299)1.49643261
124Abnormality of the dental root (HP:0006486)1.46195389
125Taurodontia (HP:0000679)1.46195389
126Abnormality of permanent molar morphology (HP:0011071)1.46195389
127Bundle branch block (HP:0011710)1.45391694
128Fibular hypoplasia (HP:0003038)1.41112482
129Hemiparesis (HP:0001269)1.40388188
130Abnormal urine output (HP:0012590)1.38084592
131Deformed sella turcica (HP:0002681)1.37590804
132Abnormality of the dental pulp (HP:0006479)1.36422981
133Absent frontal sinuses (HP:0002688)1.36348586
134Amyotrophic lateral sclerosis (HP:0007354)1.36246518
135Postaxial hand polydactyly (HP:0001162)1.35497650
136Abnormality of molar morphology (HP:0011070)1.34522894
137Abnormality of molar (HP:0011077)1.34522894
138Cystic liver disease (HP:0006706)1.31923723
139Cerebral inclusion bodies (HP:0100314)1.30920340
140Renal dysplasia (HP:0000110)1.30187130
141Aplasia/Hypoplasia of the lens (HP:0008063)1.29479571
142Hypercholesterolemia (HP:0003124)1.28882208
143Chronic sinusitis (HP:0011109)1.25749224
144J-shaped sella turcica (HP:0002680)1.25639065
145Constricted visual fields (HP:0001133)1.24930371
146Facial cleft (HP:0002006)1.22906949
147Truncal obesity (HP:0001956)1.22873934
148Broad distal phalanx of finger (HP:0009836)1.21838014
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21766687
150Microglossia (HP:0000171)1.21438990
151Sensory axonal neuropathy (HP:0003390)1.18104579
152Congenital malformation of the right heart (HP:0011723)1.17675794
153Double outlet right ventricle (HP:0001719)1.17675794
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.17482984
155Absent epiphyses (HP:0010577)1.17482984
156Nephropathy (HP:0000112)1.16836559
157Exercise-induced myalgia (HP:0003738)1.16071984
158Myoglobinuria (HP:0002913)1.15727570
159Short thorax (HP:0010306)1.14288236
160Optic neuritis (HP:0100653)1.14127248
161Retrobulbar optic neuritis (HP:0100654)1.14127248
162Supernumerary spleens (HP:0009799)1.13852883
163Glucose intolerance (HP:0000833)1.13752221
164Pancreatic fibrosis (HP:0100732)1.12820149
165Hyporeflexia of lower limbs (HP:0002600)1.11599510
166Easy fatigability (HP:0003388)1.11542959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.27264032
2PDK38.27264032
3TESK15.92231277
4PRKD35.48919693
5PDK25.35451083
6BRD44.69600144
7INSRR4.63139402
8ICK4.48736485
9PLK23.79678478
10DDR22.91223126
11MAP4K22.69085065
12PIK3CG2.61533352
13PNCK2.42064867
14PTK2B2.28629535
15WNK42.09310932
16STK391.93489714
17DYRK1B1.66127224
18STK381.56696511
19MST1R1.41911126
20NEK21.38022843
21PDK11.14504897
22AKT30.99798152
23TYRO30.98428289
24CAMK1D0.94720891
25MAPK150.90881687
26CDK70.89965660
27TIE10.89777404
28WNK10.87930609
29SIK20.84113130
30CAMK1G0.82990113
31DYRK30.80514414
32MAP3K110.78586528
33KSR20.75131929
34MAP3K90.73370083
35MAP2K60.72862734
36BRAF0.70121098
37PDPK10.66711081
38RIPK40.63371817
39PASK0.61483571
40IRAK10.59625223
41LATS20.58373109
42TESK20.54629617
43TTK0.53386508
44MAP2K20.52974846
45STK30.52807382
46CDK30.52705512
47LMTK20.51545197
48CCNB10.51379218
49EEF2K0.51279982
50CHEK20.49863088
51MARK10.48506713
52RPS6KA20.48437710
53PRKAA20.48344262
54SGK2230.46047497
55SGK4940.46047497
56PAK10.44986842
57CHEK10.40420910
58LATS10.39408963
59PINK10.39064327
60MAP3K20.38552384
61PAK20.38463346
62NTRK30.37768523
63ROCK10.35152074
64BMPR1B0.34708948
65NTRK20.34429535
66UHMK10.33012979
67PRKCG0.32078844
68IRAK20.31707215
69CAMK40.31360953
70MTOR0.30717859
71MAP3K80.30412050
72NEK60.28728938
73ATM0.28473856
74SGK10.27942697
75MAP3K100.27067529
76MAP3K40.26889019
77PAK40.25549219
78MARK20.25295466
79STK38L0.25006335
80MUSK0.24566024
81CDC70.21753846
82BLK0.21586705
83CAMKK10.21089706
84WEE10.20919438
85RPS6KC10.20504440
86RPS6KL10.20504440
87SGK20.20429569
88JAK30.20282169
89ATR0.20083859
90MAPK140.19000315
91PLK40.18284522
92PRKAA10.18205804
93MAPKAPK50.17819060
94RPS6KA60.17700876
95MAPK100.17270123
96ARAF0.16429702
97PRKCZ0.16031542
98RPS6KB10.13633285
99AKT10.13441766
100CDK120.13304617
101MET0.12593602
102TNIK0.12526930
103CDK150.12111136
104PRKCQ0.11691627
105CSNK1D0.11453263
106MAPK110.11091693
107CDK180.09565469
108CDK60.09375726
109PLK10.08836353
110GSK3B0.08654679
111OXSR10.08580647
112CDK11A0.08570216
113MAP2K70.07768125
114SGK30.06617177
115PRKG20.05646599
116RPS6KA10.05485583
117CDK140.05471006
118CSNK2A10.05042707
119MAP3K70.05001708
120BRSK20.04578060
121MAPK90.03951742
122CDK20.03950321
123CDK10.03636350
124PRKG10.03268169
125PRKCB0.03147273
126WNK30.03014276
127PKN10.02705794
128BRSK10.02617994
129CAMK2A0.02489889
130CSNK2A20.02401964
131PRKACG0.02149565
132STK100.02103635
133STK110.01831640
134MAPK80.01824318
135PAK60.01449822
136CDK40.01423715
137EPHB10.01287858
138PRKCD0.00946633
139MAP3K10.00594994
140MARK30.00586359
141PRKACA-0.0279479
142SRC-0.0254030
143CAMK1-0.0236448
144MAPK1-0.0172216
145CSF1R-0.0148468
146PIM1-0.0137644
147PRKACB-0.0099645
148RPS6KA3-0.0059383
149CLK1-0.0050499
150EGFR-0.0036300
151PRKDC-0.0030826
152PRKCA-0.0029054

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.38144221
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.80579234
3Fatty acid biosynthesis_Homo sapiens_hsa000614.66442459
4Olfactory transduction_Homo sapiens_hsa047403.98131406
5Pyruvate metabolism_Homo sapiens_hsa006203.46950946
6Vitamin B6 metabolism_Homo sapiens_hsa007503.18396321
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.01555034
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.79667203
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72901144
10Propanoate metabolism_Homo sapiens_hsa006402.68120561
11Linoleic acid metabolism_Homo sapiens_hsa005912.67849100
12Glucagon signaling pathway_Homo sapiens_hsa049222.51550766
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.50391466
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.20558698
15Butanoate metabolism_Homo sapiens_hsa006502.16929963
16Glycerolipid metabolism_Homo sapiens_hsa005611.96089212
17PPAR signaling pathway_Homo sapiens_hsa033201.94970486
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.92840009
19Selenocompound metabolism_Homo sapiens_hsa004501.84554193
20Basal transcription factors_Homo sapiens_hsa030221.83107490
21Dorso-ventral axis formation_Homo sapiens_hsa043201.77222161
22Fructose and mannose metabolism_Homo sapiens_hsa000511.67879147
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64723806
24Phenylalanine metabolism_Homo sapiens_hsa003601.64335981
25Oocyte meiosis_Homo sapiens_hsa041141.62795842
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.61806337
27Mineral absorption_Homo sapiens_hsa049781.61084662
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.60925632
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.57243539
30Fatty acid degradation_Homo sapiens_hsa000711.50846386
31Fatty acid metabolism_Homo sapiens_hsa012121.50562816
32Carbon metabolism_Homo sapiens_hsa012001.42312950
33Amphetamine addiction_Homo sapiens_hsa050311.37674412
34Pentose phosphate pathway_Homo sapiens_hsa000301.36654693
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31715457
36Fat digestion and absorption_Homo sapiens_hsa049751.27511675
37Cardiac muscle contraction_Homo sapiens_hsa042601.27437103
38Antigen processing and presentation_Homo sapiens_hsa046121.25169821
39Ether lipid metabolism_Homo sapiens_hsa005651.21680836
40Type I diabetes mellitus_Homo sapiens_hsa049401.20669560
41Phototransduction_Homo sapiens_hsa047441.20454074
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.18904237
43Renin secretion_Homo sapiens_hsa049241.08388323
44mRNA surveillance pathway_Homo sapiens_hsa030151.07488605
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.04315740
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04288437
47Autoimmune thyroid disease_Homo sapiens_hsa053201.02292413
48Allograft rejection_Homo sapiens_hsa053301.02071407
49Arginine biosynthesis_Homo sapiens_hsa002201.01353853
50Fanconi anemia pathway_Homo sapiens_hsa034601.00544600
51Biosynthesis of amino acids_Homo sapiens_hsa012300.95830094
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94964681
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94734399
54Huntingtons disease_Homo sapiens_hsa050160.93318415
55Purine metabolism_Homo sapiens_hsa002300.93048202
56Nicotine addiction_Homo sapiens_hsa050330.93000767
57Morphine addiction_Homo sapiens_hsa050320.92701972
58Bile secretion_Homo sapiens_hsa049760.90553659
59Influenza A_Homo sapiens_hsa051640.89442437
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88839773
61Insulin secretion_Homo sapiens_hsa049110.88625091
62Graft-versus-host disease_Homo sapiens_hsa053320.88567676
63RNA transport_Homo sapiens_hsa030130.88398272
64Viral myocarditis_Homo sapiens_hsa054160.84637085
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.83480734
66Hedgehog signaling pathway_Homo sapiens_hsa043400.82321287
67Thyroid hormone synthesis_Homo sapiens_hsa049180.81338353
68Collecting duct acid secretion_Homo sapiens_hsa049660.81118754
69Arginine and proline metabolism_Homo sapiens_hsa003300.80491243
70Glutathione metabolism_Homo sapiens_hsa004800.78860846
71Estrogen signaling pathway_Homo sapiens_hsa049150.77461880
72Chemical carcinogenesis_Homo sapiens_hsa052040.75324166
73Legionellosis_Homo sapiens_hsa051340.68534916
74Long-term potentiation_Homo sapiens_hsa047200.68072564
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67151177
76Tyrosine metabolism_Homo sapiens_hsa003500.65565378
77Nitrogen metabolism_Homo sapiens_hsa009100.64583594
78Arachidonic acid metabolism_Homo sapiens_hsa005900.63853468
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.62304514
80Serotonergic synapse_Homo sapiens_hsa047260.62301791
81Salivary secretion_Homo sapiens_hsa049700.60463746
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59941851
83Protein digestion and absorption_Homo sapiens_hsa049740.59892557
84Pancreatic secretion_Homo sapiens_hsa049720.55162728
85Calcium signaling pathway_Homo sapiens_hsa040200.53794075
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53587186
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53512987
88Renin-angiotensin system_Homo sapiens_hsa046140.53337250
89Gastric acid secretion_Homo sapiens_hsa049710.52935378
90ABC transporters_Homo sapiens_hsa020100.52310038
91Retinol metabolism_Homo sapiens_hsa008300.50753642
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50221152
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48498999
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48254237
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48095847
96Endocytosis_Homo sapiens_hsa041440.47124259
97Synaptic vesicle cycle_Homo sapiens_hsa047210.46272651
98Inositol phosphate metabolism_Homo sapiens_hsa005620.45625731
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.44990084
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43858893
101Taste transduction_Homo sapiens_hsa047420.43664454
102MAPK signaling pathway_Homo sapiens_hsa040100.43508470
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42168538
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39418847
105AMPK signaling pathway_Homo sapiens_hsa041520.39127980
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38699490
107GABAergic synapse_Homo sapiens_hsa047270.37960641
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.37293105
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36756742
110Circadian entrainment_Homo sapiens_hsa047130.35659033
111Cholinergic synapse_Homo sapiens_hsa047250.35528199
112cAMP signaling pathway_Homo sapiens_hsa040240.35385258
113Sulfur metabolism_Homo sapiens_hsa009200.34991928
114Metabolic pathways_Homo sapiens_hsa011000.34560917
115ECM-receptor interaction_Homo sapiens_hsa045120.34321624
116Tight junction_Homo sapiens_hsa045300.31818194
117Acute myeloid leukemia_Homo sapiens_hsa052210.30785885
118Oxytocin signaling pathway_Homo sapiens_hsa049210.30750174
119VEGF signaling pathway_Homo sapiens_hsa043700.29240953
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27529197
121Sulfur relay system_Homo sapiens_hsa041220.26609751
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.25433339
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25273709
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21429175
125Cocaine addiction_Homo sapiens_hsa050300.17842103
126Pyrimidine metabolism_Homo sapiens_hsa002400.15516450
127Herpes simplex infection_Homo sapiens_hsa051680.15267559
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14157741
129Systemic lupus erythematosus_Homo sapiens_hsa053220.13731647
130Type II diabetes mellitus_Homo sapiens_hsa049300.08599979
131HIF-1 signaling pathway_Homo sapiens_hsa040660.08479143
132Basal cell carcinoma_Homo sapiens_hsa052170.05489595
133Glutamatergic synapse_Homo sapiens_hsa047240.05123204
134Insulin resistance_Homo sapiens_hsa049310.05043119
135N-Glycan biosynthesis_Homo sapiens_hsa005100.04988115
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.04676755
137B cell receptor signaling pathway_Homo sapiens_hsa046620.04351669

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