AKAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.47683305
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22905009
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.03887422
4ATP synthesis coupled proton transport (GO:0015986)5.78736781
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.78736781
6neuron cell-cell adhesion (GO:0007158)5.48307454
7vocalization behavior (GO:0071625)5.06916211
8respiratory electron transport chain (GO:0022904)5.00422101
9gamma-aminobutyric acid transport (GO:0015812)4.95601880
10behavioral response to nicotine (GO:0035095)4.94121042
11electron transport chain (GO:0022900)4.90255323
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.84800682
13inner mitochondrial membrane organization (GO:0007007)4.81214329
14response to histamine (GO:0034776)4.66044956
15protein localization to synapse (GO:0035418)4.46545555
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37900273
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34346617
18neuron recognition (GO:0008038)4.33112220
19transmission of nerve impulse (GO:0019226)4.25120488
20dopamine transport (GO:0015872)4.18043668
21positive regulation of synapse assembly (GO:0051965)4.12350922
22mating behavior (GO:0007617)4.10615158
23synaptic vesicle exocytosis (GO:0016079)4.10492212
24L-fucose catabolic process (GO:0042355)4.04640936
25fucose catabolic process (GO:0019317)4.04640936
26L-fucose metabolic process (GO:0042354)4.04640936
27response to pheromone (GO:0019236)4.02722634
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94526541
29neurotransmitter catabolic process (GO:0042135)3.93476699
30regulation of glutamate receptor signaling pathway (GO:1900449)3.91523626
31synaptic vesicle maturation (GO:0016188)3.84738609
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83999485
33presynaptic membrane assembly (GO:0097105)3.82528723
34regulation of glutamate secretion (GO:0014048)3.76088319
35glutamate receptor signaling pathway (GO:0007215)3.75821108
36energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.72231466
37ATP hydrolysis coupled proton transport (GO:0015991)3.72231466
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71446484
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.70695313
40chaperone-mediated protein transport (GO:0072321)3.59951246
41startle response (GO:0001964)3.52551554
42presynaptic membrane organization (GO:0097090)3.52323198
43suckling behavior (GO:0001967)3.51709735
44protein localization to cilium (GO:0061512)3.46306834
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45435567
46detection of calcium ion (GO:0005513)3.44862682
47cAMP catabolic process (GO:0006198)3.44285883
48dopamine biosynthetic process (GO:0042416)3.43038782
49hydrogen ion transmembrane transport (GO:1902600)3.41547563
50synaptic transmission, dopaminergic (GO:0001963)3.41546521
51neuron remodeling (GO:0016322)3.41228324
52catecholamine transport (GO:0051937)3.40924770
53neuron-neuron synaptic transmission (GO:0007270)3.40890250
54serotonin metabolic process (GO:0042428)3.39258636
55neurotransmitter secretion (GO:0007269)3.38229564
56neuronal action potential propagation (GO:0019227)3.32797323
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31687112
58primary amino compound metabolic process (GO:1901160)3.31322769
59opioid receptor signaling pathway (GO:0038003)3.30120293
60axonal fasciculation (GO:0007413)3.29168732
61C4-dicarboxylate transport (GO:0015740)3.26070290
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24980006
63neurotransmitter transport (GO:0006836)3.21968784
64postsynaptic membrane organization (GO:0001941)3.20368159
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19089733
66regulation of action potential (GO:0098900)3.18256634
67regulation of vesicle fusion (GO:0031338)3.17144595
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13170002
69regulation of postsynaptic membrane potential (GO:0060078)3.12822320
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12578174
71righting reflex (GO:0060013)3.12491281
72locomotory exploration behavior (GO:0035641)3.10664579
73cyclic nucleotide catabolic process (GO:0009214)3.10473710
74dendritic spine morphogenesis (GO:0060997)3.10402903
75glutamate secretion (GO:0014047)3.10399288
76oxygen transport (GO:0015671)3.08623004
77regulation of neurotransmitter levels (GO:0001505)3.08077805
78neuronal action potential (GO:0019228)3.07884354
79synapse assembly (GO:0007416)3.07422482
80ATP biosynthetic process (GO:0006754)3.06260075
81protein K11-linked deubiquitination (GO:0035871)3.05633995
82proton transport (GO:0015992)3.05509206
83membrane depolarization during action potential (GO:0086010)3.05462705
84neuromuscular synaptic transmission (GO:0007274)3.04862420
85layer formation in cerebral cortex (GO:0021819)3.04313875
86regulation of synapse assembly (GO:0051963)3.03837294
87transferrin transport (GO:0033572)3.03629691
88regulation of synaptic vesicle exocytosis (GO:2000300)3.03587066
89female mating behavior (GO:0060180)3.03072725
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02544628
91indolalkylamine metabolic process (GO:0006586)3.02046077
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02033825
93hydrogen transport (GO:0006818)3.01486843
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98703974
95kynurenine metabolic process (GO:0070189)2.98530803
96negative regulation of amino acid transport (GO:0051956)2.98341933
97indole-containing compound metabolic process (GO:0042430)2.97661536
98neurotransmitter biosynthetic process (GO:0042136)2.96707664
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.96344670
100synaptic transmission, glutamatergic (GO:0035249)2.93910285
101DNA deamination (GO:0045006)2.93852829
102striatum development (GO:0021756)2.92980375
103purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92071825
104proline transport (GO:0015824)2.90914417
105behavioral response to cocaine (GO:0048148)2.89589802
106exploration behavior (GO:0035640)2.89549794
107GTP biosynthetic process (GO:0006183)2.89540563
108neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89370116
109cellular ketone body metabolic process (GO:0046950)2.89073865
110fear response (GO:0042596)2.87893725
111reflex (GO:0060004)2.86791748
112regulation of dopamine metabolic process (GO:0042053)2.85605290
113regulation of catecholamine metabolic process (GO:0042069)2.85605290
114long-term memory (GO:0007616)2.83754191
115trivalent inorganic cation transport (GO:0072512)2.83687795
116ferric iron transport (GO:0015682)2.83687795
117social behavior (GO:0035176)2.83306035
118intraspecies interaction between organisms (GO:0051703)2.83306035
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.82925177
120retinal cone cell development (GO:0046549)2.82441603
121indole-containing compound catabolic process (GO:0042436)2.82137808
122indolalkylamine catabolic process (GO:0046218)2.82137808
123tryptophan catabolic process (GO:0006569)2.82137808
124behavioral defense response (GO:0002209)2.81769524
125behavioral fear response (GO:0001662)2.81769524
126detection of light stimulus involved in sensory perception (GO:0050962)2.80961249
127detection of light stimulus involved in visual perception (GO:0050908)2.80961249
128membrane hyperpolarization (GO:0060081)2.79640052
129water-soluble vitamin biosynthetic process (GO:0042364)2.77599443
130positive regulation of action potential (GO:0045760)2.76120546
131regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76057922
132negative regulation of neurotransmitter transport (GO:0051589)2.75892608
133alanine transport (GO:0032328)2.74411224
134protein neddylation (GO:0045116)2.72255680
135epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70828256
136pyrimidine nucleobase catabolic process (GO:0006208)2.70741344
137multi-organism reproductive behavior (GO:0044705)2.69533780
138membrane depolarization (GO:0051899)2.68863802
139protein-cofactor linkage (GO:0018065)2.68290319
140tryptophan metabolic process (GO:0006568)2.65912004
141detection of mechanical stimulus involved in sensory perception (GO:0050974)2.64903597
142nucleobase catabolic process (GO:0046113)2.61525282
143regulation of neurotransmitter uptake (GO:0051580)2.59265979
144regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54665277
145behavioral response to ethanol (GO:0048149)2.54207543
146action potential (GO:0001508)2.52151621
147* synaptic transmission (GO:0007268)2.51452257
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51288151
149ketone body metabolic process (GO:1902224)2.51059808
150regulation of cilium movement (GO:0003352)2.50530106
151sulfation (GO:0051923)2.50086002
152protein polyglutamylation (GO:0018095)2.48116038
153negative regulation of telomere maintenance (GO:0032205)2.47788403
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.45362489
155regulation of synapse structural plasticity (GO:0051823)2.41599026
156cellular potassium ion transport (GO:0071804)2.41248999
157potassium ion transmembrane transport (GO:0071805)2.41248999
158auditory behavior (GO:0031223)2.40705063
159regulation of synaptic vesicle transport (GO:1902803)2.38591254
160glycosphingolipid biosynthetic process (GO:0006688)2.37811164
161neural tube formation (GO:0001841)2.37503117
162regulation of neurotransmitter transport (GO:0051588)2.36429491
163activated T cell proliferation (GO:0050798)2.36372579
164atrial cardiac muscle cell action potential (GO:0086014)2.34945060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34205700
2TAF15_26573619_Chip-Seq_HEK293_Human3.54338513
3GBX2_23144817_ChIP-Seq_PC3_Human3.38209767
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00516049
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99472902
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89527480
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64137578
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55137642
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.45834586
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.45708752
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45675686
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43439751
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42055480
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42055480
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.37467211
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36456579
17REST_21632747_ChIP-Seq_MESCs_Mouse2.35660009
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32305744
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31354801
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27660000
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26313554
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20952584
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15540712
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14010670
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07515132
26IGF1R_20145208_ChIP-Seq_DFB_Human2.01450920
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94122998
28P300_19829295_ChIP-Seq_ESCs_Human1.92307793
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85810532
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.85723812
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.83166399
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81412013
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.79559712
34SMAD4_21799915_ChIP-Seq_A2780_Human1.78818447
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.78510236
36* FUS_26573619_Chip-Seq_HEK293_Human1.78129258
37AR_21572438_ChIP-Seq_LNCaP_Human1.77908999
38VDR_22108803_ChIP-Seq_LS180_Human1.77573049
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75265830
40ZNF274_21170338_ChIP-Seq_K562_Hela1.70398270
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68078355
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.64962243
43RNF2_27304074_Chip-Seq_NSC_Mouse1.64689363
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64077845
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61320337
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60413345
47ER_23166858_ChIP-Seq_MCF-7_Human1.60056666
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56625539
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53868356
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51584502
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.50423446
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49880915
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47099003
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.46582477
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43390452
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43024764
57DROSHA_22980978_ChIP-Seq_HELA_Human1.41418582
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41210650
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40159534
60TP53_22573176_ChIP-Seq_HFKS_Human1.39232725
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37573031
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37326191
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.36716084
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31786012
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30711775
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30623470
67AR_25329375_ChIP-Seq_VCAP_Human1.29533471
68JUN_21703547_ChIP-Seq_K562_Human1.28630624
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27838830
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27345190
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26589590
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25393959
73RUNX2_22187159_ChIP-Seq_PCA_Human1.23569302
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21938822
75EWS_26573619_Chip-Seq_HEK293_Human1.19797630
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.19761106
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19715122
78TCF4_22108803_ChIP-Seq_LS180_Human1.18526125
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.17184513
80NANOG_19829295_ChIP-Seq_ESCs_Human1.16989220
81SOX2_19829295_ChIP-Seq_ESCs_Human1.16989220
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16418117
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.16354876
84IRF1_19129219_ChIP-ChIP_H3396_Human1.15043881
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.14937598
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13184294
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12667591
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12499557
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.12438836
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11974870
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11704915
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10552244
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08850896
94P53_22387025_ChIP-Seq_ESCs_Mouse1.08520427
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.08233881
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08215145
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08202037
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.08202037
99* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05597040
100BCAT_22108803_ChIP-Seq_LS180_Human1.05405550
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05015427
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04933590
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04180206
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.03344142
105TP53_18474530_ChIP-ChIP_U2OS_Human1.03298883
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02879776
107STAT3_23295773_ChIP-Seq_U87_Human1.01862175
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01579359
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.01486283
110NCOR_22424771_ChIP-Seq_293T_Human1.01462265
111MYC_18940864_ChIP-ChIP_HL60_Human1.00976021
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.00873392
113TCF4_23295773_ChIP-Seq_U87_Human1.00866992
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.00187923
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98749225
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98023773
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97757679
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97515329
119KDM2B_26808549_Chip-Seq_REH_Human0.97416736
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97289576
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.93745802
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93083791
123CBP_20019798_ChIP-Seq_JUKART_Human0.92962141
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92962141
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91135601
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90586982
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90348621
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90348621
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89332440
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.87325648
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86271420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.66699145
2MP0001529_abnormal_vocalization3.78251452
3MP0006276_abnormal_autonomic_nervous3.63062552
4MP0004859_abnormal_synaptic_plasticity3.40621784
5MP0009046_muscle_twitch3.33820069
6* MP0003635_abnormal_synaptic_transmissio3.32492472
7MP0001968_abnormal_touch/_nociception3.17120505
8* MP0009745_abnormal_behavioral_response3.13099428
9* MP0002064_seizures2.99667035
10MP0001440_abnormal_grooming_behavior2.95370919
11MP0003122_maternal_imprinting2.77743023
12MP0002736_abnormal_nociception_after2.73161143
13MP0001501_abnormal_sleep_pattern2.56102379
14MP0000569_abnormal_digit_pigmentation2.54972153
15* MP0002572_abnormal_emotion/affect_behav2.53891427
16* MP0002063_abnormal_learning/memory/cond2.52999862
17MP0002272_abnormal_nervous_system2.49497011
18MP0005423_abnormal_somatic_nervous2.46777707
19MP0004142_abnormal_muscle_tone2.46681336
20MP0008877_abnormal_DNA_methylation2.39978984
21MP0001986_abnormal_taste_sensitivity2.31364344
22MP0001905_abnormal_dopamine_level2.29461329
23MP0002734_abnormal_mechanical_nocicepti2.23165565
24MP0004270_analgesia2.20873557
25MP0001486_abnormal_startle_reflex2.20563153
26MP0005386_behavior/neurological_phenoty2.13274888
27MP0004924_abnormal_behavior2.13274888
28MP0002067_abnormal_sensory_capabilities2.08875452
29MP0002837_dystrophic_cardiac_calcinosis2.08637719
30MP0002822_catalepsy2.01419816
31MP0002735_abnormal_chemical_nociception1.96636675
32MP0002733_abnormal_thermal_nociception1.93269655
33MP0001970_abnormal_pain_threshold1.92038848
34MP0005645_abnormal_hypothalamus_physiol1.89549403
35MP0004885_abnormal_endolymph1.88660543
36MP0001984_abnormal_olfaction1.88433267
37MP0004147_increased_porphyrin_level1.81124226
38MP0003195_calcinosis1.72568005
39MP0002557_abnormal_social/conspecific_i1.68516403
40MP0001188_hyperpigmentation1.67029674
41MP0002184_abnormal_innervation1.65854238
42MP0003329_amyloid_beta_deposits1.64351588
43MP0000778_abnormal_nervous_system1.62527154
44MP0000427_abnormal_hair_cycle1.49233452
45MP0005646_abnormal_pituitary_gland1.46869484
46MP0006072_abnormal_retinal_apoptosis1.46690888
47MP0000751_myopathy1.46203949
48MP0005379_endocrine/exocrine_gland_phen1.43143066
49MP0004043_abnormal_pH_regulation1.38853737
50MP0006035_abnormal_mitochondrial_morpho1.36642369
51MP0010386_abnormal_urinary_bladder1.36203424
52MP0004742_abnormal_vestibular_system1.34847879
53MP0009379_abnormal_foot_pigmentation1.34193336
54MP0004133_heterotaxia1.34168186
55MP0002876_abnormal_thyroid_physiology1.33997583
56MP0001485_abnormal_pinna_reflex1.33601622
57MP0001502_abnormal_circadian_rhythm1.33543478
58MP0008872_abnormal_physiological_respon1.32612112
59* MP0002066_abnormal_motor_capabilities/c1.26947351
60MP0005551_abnormal_eye_electrophysiolog1.26138405
61MP0005409_darkened_coat_color1.24874311
62MP0005084_abnormal_gallbladder_morpholo1.21438984
63MP0002882_abnormal_neuron_morphology1.17086421
64MP0002332_abnormal_exercise_endurance1.14343336
65MP0005174_abnormal_tail_pigmentation1.13233779
66MP0003121_genomic_imprinting1.11045126
67MP0008569_lethality_at_weaning1.09024129
68MP0000955_abnormal_spinal_cord1.05925048
69MP0000631_abnormal_neuroendocrine_gland1.05744332
70MP0004145_abnormal_muscle_electrophysio1.05528203
71MP0008875_abnormal_xenobiotic_pharmacok1.04860388
72MP0003011_delayed_dark_adaptation1.03471703
73MP0000013_abnormal_adipose_tissue1.02654703
74MP0005535_abnormal_body_temperature1.02270300
75MP0002163_abnormal_gland_morphology1.00581063
76MP0003890_abnormal_embryonic-extraembry0.98968290
77MP0002229_neurodegeneration0.96823366
78MP0003123_paternal_imprinting0.96358563
79MP0002909_abnormal_adrenal_gland0.94636337
80MP0002152_abnormal_brain_morphology0.90225673
81MP0002090_abnormal_vision0.90049321
82MP0004811_abnormal_neuron_physiology0.88981002
83MP0002160_abnormal_reproductive_system0.88196571
84MP0001963_abnormal_hearing_physiology0.88173499
85MP0002069_abnormal_eating/drinking_beha0.87883373
86MP0001919_abnormal_reproductive_system0.87688152
87MP0003633_abnormal_nervous_system0.85110308
88MP0001664_abnormal_digestion0.83904339
89MP0003879_abnormal_hair_cell0.83335810
90MP0002752_abnormal_somatic_nervous0.82878350
91MP0004085_abnormal_heartbeat0.82580636
92MP0005389_reproductive_system_phenotype0.82218597
93MP0002638_abnormal_pupillary_reflex0.81045312
94MP0005394_taste/olfaction_phenotype0.79388750
95MP0005499_abnormal_olfactory_system0.79388750
96MP0000747_muscle_weakness0.77990604
97MP0003690_abnormal_glial_cell0.77661139
98MP0000604_amyloidosis0.77429136
99MP0008874_decreased_physiological_sensi0.76760805
100MP0005671_abnormal_response_to0.75904959
101MP0002751_abnormal_autonomic_nervous0.75559554
102MP0002928_abnormal_bile_duct0.75550906
103MP0003137_abnormal_impulse_conducting0.74631307
104MP0003634_abnormal_glial_cell0.74367563
105MP0003631_nervous_system_phenotype0.74011722
106MP0004858_abnormal_nervous_system0.72347401
107MP0005195_abnormal_posterior_eye0.72094768
108MP0001943_abnormal_respiration0.71733930
109MP0000538_abnormal_urinary_bladder0.70948616
110MP0002234_abnormal_pharynx_morphology0.69266100
111MP0003938_abnormal_ear_development0.68550634
112MP0002277_abnormal_respiratory_mucosa0.68195020
113MP0009780_abnormal_chondrocyte_physiolo0.68169077
114MP0000920_abnormal_myelination0.68159874
115MP0003252_abnormal_bile_duct0.67776226
116MP0000639_abnormal_adrenal_gland0.67672136
117MP0003698_abnormal_male_reproductive0.67346360
118MP0005310_abnormal_salivary_gland0.67110671
119MP0000026_abnormal_inner_ear0.66760342
120MP0002102_abnormal_ear_morphology0.66721753
121MP0003787_abnormal_imprinting0.65845896
122MP0001727_abnormal_embryo_implantation0.64780385
123MP0005623_abnormal_meninges_morphology0.64738113
124MP0004272_abnormal_basement_membrane0.64646284
125MP0005253_abnormal_eye_physiology0.63816447
126MP0004215_abnormal_myocardial_fiber0.63276366
127MP0006292_abnormal_olfactory_placode0.63064933
128MP0004484_altered_response_of0.62481395
129MP0001177_atelectasis0.59573507

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.23137663
2Acute necrotizing encephalopathy (HP:0006965)5.08066870
3Atonic seizures (HP:0010819)4.60002860
4Progressive macrocephaly (HP:0004481)4.58553626
5Abnormal mitochondria in muscle tissue (HP:0008316)4.53370958
6Focal seizures (HP:0007359)4.43831136
7Mitochondrial inheritance (HP:0001427)4.38963746
8Visual hallucinations (HP:0002367)4.33001558
9Absence seizures (HP:0002121)4.08460945
10Type II lissencephaly (HP:0007260)4.04021749
11Acute encephalopathy (HP:0006846)3.97712663
12Limb dystonia (HP:0002451)3.79936362
13Pancreatic cysts (HP:0001737)3.71723674
14Myokymia (HP:0002411)3.70861924
15Dialeptic seizures (HP:0011146)3.70077123
16Abnormal ciliary motility (HP:0012262)3.60634117
17Febrile seizures (HP:0002373)3.56585325
18Infantile muscular hypotonia (HP:0008947)3.56133172
19Increased CSF lactate (HP:0002490)3.52418044
20Generalized tonic-clonic seizures (HP:0002069)3.45465027
21Epileptic encephalopathy (HP:0200134)3.38376280
22Congenital stationary night blindness (HP:0007642)3.36815080
23Pancreatic fibrosis (HP:0100732)3.35493561
24Polyphagia (HP:0002591)3.28080759
25Increased hepatocellular lipid droplets (HP:0006565)3.26316555
26Hepatocellular necrosis (HP:0001404)3.22489360
27True hermaphroditism (HP:0010459)3.14127745
28Cerebral inclusion bodies (HP:0100314)3.09779720
29Neurofibrillary tangles (HP:0002185)3.01428187
30Gait imbalance (HP:0002141)3.00137648
31Optic disc pallor (HP:0000543)2.98111954
32Cerebellar dysplasia (HP:0007033)2.97049476
33Abnormal respiratory motile cilium physiology (HP:0012261)2.95366497
34Progressive cerebellar ataxia (HP:0002073)2.92739202
35Nephronophthisis (HP:0000090)2.92384936
36Abnormal respiratory epithelium morphology (HP:0012253)2.90699212
37Abnormal respiratory motile cilium morphology (HP:0005938)2.90699212
38Hyperventilation (HP:0002883)2.89937735
39Progressive inability to walk (HP:0002505)2.83566679
40Broad-based gait (HP:0002136)2.81144688
41Absent/shortened dynein arms (HP:0200106)2.80787305
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.80787305
43Renal Fanconi syndrome (HP:0001994)2.79161651
44Genetic anticipation (HP:0003743)2.78737570
45Congenital primary aphakia (HP:0007707)2.75912084
46Chronic hepatic failure (HP:0100626)2.73871962
47Medial flaring of the eyebrow (HP:0010747)2.73406225
48Abnormality of the pons (HP:0007361)2.72897790
49Abnormal hair whorl (HP:0010721)2.72437791
50Abnormality of the renal cortex (HP:0011035)2.69656523
51Lipid accumulation in hepatocytes (HP:0006561)2.66887051
52Attenuation of retinal blood vessels (HP:0007843)2.62778451
53Abolished electroretinogram (ERG) (HP:0000550)2.62722889
54Amblyopia (HP:0000646)2.60173046
55Hypothermia (HP:0002045)2.59816188
56Pendular nystagmus (HP:0012043)2.59410369
57Anxiety (HP:0000739)2.59259441
58Abnormal eating behavior (HP:0100738)2.58773760
59Abnormality of the renal medulla (HP:0100957)2.58141316
60Cerebral edema (HP:0002181)2.58140212
61Absent speech (HP:0001344)2.50160415
62Abnormal pupillary function (HP:0007686)2.49682227
63Hyperthyroidism (HP:0000836)2.48060572
64Leukodystrophy (HP:0002415)2.46931580
65Nephrogenic diabetes insipidus (HP:0009806)2.46622529
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45653445
67Esotropia (HP:0000565)2.44807783
68Protruding tongue (HP:0010808)2.43746451
69Retinal dysplasia (HP:0007973)2.43199202
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.41324062
71Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41324062
72Genital tract atresia (HP:0001827)2.41068476
73Vaginal atresia (HP:0000148)2.39244612
74Hypoplasia of the pons (HP:0012110)2.38457587
75Pheochromocytoma (HP:0002666)2.38203886
76Failure to thrive in infancy (HP:0001531)2.36428675
77Brushfield spots (HP:0001088)2.36405376
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.33584570
79Cerebral hemorrhage (HP:0001342)2.32532964
80Psychosis (HP:0000709)2.30466924
81Neuroendocrine neoplasm (HP:0100634)2.30454356
82Abnormality of midbrain morphology (HP:0002418)2.29390242
83Molar tooth sign on MRI (HP:0002419)2.29390242
84Rhinitis (HP:0012384)2.26721262
85Respiratory failure (HP:0002878)2.26263964
86Exercise intolerance (HP:0003546)2.26141459
87Increased intramyocellular lipid droplets (HP:0012240)2.24916548
88Rimmed vacuoles (HP:0003805)2.23944516
89Drooling (HP:0002307)2.23802747
90Excessive salivation (HP:0003781)2.23802747
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.21344372
92Truncal ataxia (HP:0002078)2.21332717
93Hemiparesis (HP:0001269)2.20865148
94Agitation (HP:0000713)2.18779214
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16840454
96Pachygyria (HP:0001302)2.16432180
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15687036
98Abnormality of alanine metabolism (HP:0010916)2.15687036
99Hyperalaninemia (HP:0003348)2.15687036
100CNS hypomyelination (HP:0003429)2.15518890
101X-linked dominant inheritance (HP:0001423)2.15031110
102Tubular atrophy (HP:0000092)2.14394699
103Decreased central vision (HP:0007663)2.14203190
104Abnormality of the corticospinal tract (HP:0002492)2.13633200
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12963210
106Thyroid-stimulating hormone excess (HP:0002925)2.12559253
107Hypoventilation (HP:0002791)2.11279266
108Dysmetria (HP:0001310)2.11274624
109Hepatic necrosis (HP:0002605)2.10832931
110Cystic liver disease (HP:0006706)2.10594842
111Abnormal drinking behavior (HP:0030082)2.10217007
112Polydipsia (HP:0001959)2.10217007
113Hypsarrhythmia (HP:0002521)2.08432114
114Narrow nasal bridge (HP:0000446)2.06949259
115Delusions (HP:0000746)2.05669669
116Widely spaced teeth (HP:0000687)2.05571636
117Inability to walk (HP:0002540)2.05309045
118Abnormal rod and cone electroretinograms (HP:0008323)2.04795582
119Supranuclear gaze palsy (HP:0000605)2.04174350
120Urinary bladder sphincter dysfunction (HP:0002839)2.03616301
121Fair hair (HP:0002286)2.03195506
122Generalized myoclonic seizures (HP:0002123)2.02426119
123Large for gestational age (HP:0001520)2.02210820
124Lissencephaly (HP:0001339)2.01080384
125Poor suck (HP:0002033)2.00564704
126Delayed gross motor development (HP:0002194)1.99754093
127Lactic acidosis (HP:0003128)1.98074628
128Insidious onset (HP:0003587)1.96687221
129Termporal pattern (HP:0011008)1.96687221
130Specific learning disability (HP:0001328)1.95991326
131Epileptiform EEG discharges (HP:0011182)1.94134180
132Oligomenorrhea (HP:0000876)1.93814835
133Severe muscular hypotonia (HP:0006829)1.92981594
134Renal cortical cysts (HP:0000803)1.91139851
135EEG with generalized epileptiform discharges (HP:0011198)1.90196144
136Sensory axonal neuropathy (HP:0003390)1.90100647
137Stomach cancer (HP:0012126)1.89986827
138Dysdiadochokinesis (HP:0002075)1.89197957
139Abnormality of the labia minora (HP:0012880)1.88234728
140Keratoconus (HP:0000563)1.87592975
141Increased corneal curvature (HP:0100692)1.87592975
142Gaze-evoked nystagmus (HP:0000640)1.85098344
143Postural tremor (HP:0002174)1.84598789
144Abnormality of renal resorption (HP:0011038)1.84264838
145Status epilepticus (HP:0002133)1.82579033
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.82475541
147Abnormality of macular pigmentation (HP:0008002)1.80896461
148Decreased circulating renin level (HP:0003351)1.79109031
149Intellectual disability, severe (HP:0010864)1.78467284
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76240442
151Action tremor (HP:0002345)1.74279161
152Chorioretinal atrophy (HP:0000533)1.73365372
153Congenital hepatic fibrosis (HP:0002612)1.72698814
154Polyuria (HP:0000103)1.71369867
155Generalized hypopigmentation of hair (HP:0011358)1.71312290
156Sclerocornea (HP:0000647)1.71183083
157Clumsiness (HP:0002312)1.70929252
158Oligodactyly (hands) (HP:0001180)1.69223702
159Furrowed tongue (HP:0000221)1.68146181
160Poor coordination (HP:0002370)1.67656723
161Optic nerve hypoplasia (HP:0000609)1.67512135
162Progressive microcephaly (HP:0000253)1.67015935
163Patellar aplasia (HP:0006443)1.65746198
164Aplasia/Hypoplasia of the patella (HP:0006498)1.65501648
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65094910
166Spastic tetraplegia (HP:0002510)1.63640124
167Hemiplegia (HP:0002301)1.62381888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.66809599
2PNCK4.49901324
3MAP3K124.41700473
4NTRK33.75469311
5CASK3.08547654
6MAP3K92.82067360
7MAP3K42.74526879
8ARAF2.60515761
9EPHA42.53526215
10TNIK2.35859607
11MAP2K72.34569579
12PINK12.25053584
13MAP2K42.24833494
14MAP4K22.24129361
15ZAK2.20723954
16MINK12.11996608
17NME12.06706767
18GRK12.03858170
19RIPK41.96718765
20NUAK11.96638652
21NTRK21.92851877
22NTRK11.90826502
23MARK11.86958989
24GRK71.86869310
25FES1.84734094
26TLK11.83056647
27ACVR1B1.76847699
28GRK51.70094520
29ADRBK21.59684604
30MAPKAPK51.48750676
31MAP3K131.46659087
32PLK21.43197672
33TXK1.42505346
34TAOK31.39642745
35INSRR1.34787703
36STK391.33120159
37CAMK2A1.30596133
38OXSR11.29607764
39CAMK2B1.23234014
40FGR1.22385944
41BCR1.19864542
42SIK21.17662791
43MAPK131.15444352
44KSR21.12238218
45CDK51.09267126
46BMPR21.06640554
47TRIM281.06398873
48CAMK2D1.04996973
49TNK21.02669771
50EPHA31.02007333
51MYLK0.99364670
52DYRK20.98830095
53PRKCG0.97764160
54CSNK1G20.97588392
55CSNK1G30.94964498
56UHMK10.93931769
57LATS20.93478869
58ADRBK10.91837800
59MKNK20.91557050
60FER0.91327570
61STK38L0.90991972
62KSR10.90236441
63CDK190.90160070
64CAMK1G0.87346084
65MST40.86863692
66PAK60.85845645
67PRKCH0.85501862
68CAMKK20.83617413
69FGFR20.82482604
70PRKCE0.81575055
71GRK60.81208334
72PAK30.81139153
73PIK3CA0.80701372
74BMPR1B0.78308797
75CAMK2G0.77019942
76PRKD30.76431384
77MAP2K60.76313812
78DAPK10.75901015
79WNK40.75266698
80MAPK150.74567605
81SGK20.74266688
82CDK140.72945078
83DAPK20.69059338
84PTK2B0.68938683
85MOS0.68652391
86BRAF0.68187046
87TSSK60.68067297
88SGK4940.66990316
89SGK2230.66990316
90RAF10.65821720
91MAP3K60.65339933
92ROCK20.64129281
93ERBB30.63554989
94AKT30.62419139
95CDK180.62229536
96CCNB10.62056672
97CAMK1D0.61966559
98CAMK40.61176582
99MUSK0.60483016
100CDK150.59961593
101CSNK1G10.55231535
102PRKACA0.53066589
103PKN10.52650066
104PLK30.52324697
105PRKCI0.51293892
106WNK30.50542089
107CDK11A0.49141975
108DYRK1A0.48705104
109STK110.48291769
110MARK30.48024929
111WNK10.47576898
112CSNK1E0.45605097
113CAMK10.45521322
114PRKG10.45297711
115PHKG10.45146490
116PHKG20.45146490
117CSNK1A10.44218714
118CSNK1D0.43928694
119YES10.43190073
120RPS6KA50.42931476
121VRK10.42229063
122MAP2K10.41173025
123CSNK1A1L0.40618851
124TGFBR10.39895475
125SGK10.39818198
126CAMKK10.39041213
127TAF10.38124159
128FYN0.37485969
129MAP3K10.36116646
130TEC0.35724771
131SIK30.35321382
132PRKCA0.35015500
133STK380.34424418
134PDK10.33427201
135PRKCB0.32682497
136RPS6KA30.31754152
137PRKCQ0.29764439
138PRKCZ0.29161704
139TYRO30.28413177
140RET0.26735565

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.89312103
2Nicotine addiction_Homo sapiens_hsa050334.27853507
3Parkinsons disease_Homo sapiens_hsa050123.92548731
4Alzheimers disease_Homo sapiens_hsa050103.33888892
5Collecting duct acid secretion_Homo sapiens_hsa049662.90890907
6Huntingtons disease_Homo sapiens_hsa050162.77844463
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72549601
8Synaptic vesicle cycle_Homo sapiens_hsa047212.70612272
9GABAergic synapse_Homo sapiens_hsa047272.57427052
10Cardiac muscle contraction_Homo sapiens_hsa042602.47657155
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28025827
12Morphine addiction_Homo sapiens_hsa050322.19112506
13Linoleic acid metabolism_Homo sapiens_hsa005912.15664027
14Amphetamine addiction_Homo sapiens_hsa050312.13994710
15Taste transduction_Homo sapiens_hsa047422.10413226
16Long-term potentiation_Homo sapiens_hsa047202.06804589
17Serotonergic synapse_Homo sapiens_hsa047262.01479090
18Olfactory transduction_Homo sapiens_hsa047401.94222462
19Glutamatergic synapse_Homo sapiens_hsa047241.93717253
20Circadian entrainment_Homo sapiens_hsa047131.91941658
21Selenocompound metabolism_Homo sapiens_hsa004501.86909319
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85569983
23Renin secretion_Homo sapiens_hsa049241.83632987
24Nitrogen metabolism_Homo sapiens_hsa009101.80949130
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79623253
26Dopaminergic synapse_Homo sapiens_hsa047281.76838971
27Cocaine addiction_Homo sapiens_hsa050301.74929353
28Vibrio cholerae infection_Homo sapiens_hsa051101.73912080
29Long-term depression_Homo sapiens_hsa047301.69882587
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69506821
31Salivary secretion_Homo sapiens_hsa049701.59115128
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46864048
33Calcium signaling pathway_Homo sapiens_hsa040201.39623582
34Cholinergic synapse_Homo sapiens_hsa047251.37963133
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.36095794
36Caffeine metabolism_Homo sapiens_hsa002321.35296483
37Gastric acid secretion_Homo sapiens_hsa049711.34603357
38Insulin secretion_Homo sapiens_hsa049111.33985344
39Oxytocin signaling pathway_Homo sapiens_hsa049211.25325417
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21978123
41Basal transcription factors_Homo sapiens_hsa030221.21483271
42Phototransduction_Homo sapiens_hsa047441.18003836
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15897688
44Tryptophan metabolism_Homo sapiens_hsa003801.15461277
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14973444
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12784301
47RNA polymerase_Homo sapiens_hsa030201.11903865
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11014020
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06066348
50GnRH signaling pathway_Homo sapiens_hsa049121.05608211
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05466165
52Regulation of autophagy_Homo sapiens_hsa041401.04677248
53Homologous recombination_Homo sapiens_hsa034401.04496606
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99015417
55Gap junction_Homo sapiens_hsa045400.99004327
56Rheumatoid arthritis_Homo sapiens_hsa053230.97864909
57Estrogen signaling pathway_Homo sapiens_hsa049150.91624465
58Fanconi anemia pathway_Homo sapiens_hsa034600.90634258
59Protein export_Homo sapiens_hsa030600.88860592
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.85894469
61Primary immunodeficiency_Homo sapiens_hsa053400.85680020
62Propanoate metabolism_Homo sapiens_hsa006400.83904949
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81908264
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.81674371
65Peroxisome_Homo sapiens_hsa041460.80939039
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77985893
67Melanogenesis_Homo sapiens_hsa049160.77059531
68ABC transporters_Homo sapiens_hsa020100.76695012
69Axon guidance_Homo sapiens_hsa043600.75354090
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74554851
71Circadian rhythm_Homo sapiens_hsa047100.71259918
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70228330
73Mineral absorption_Homo sapiens_hsa049780.68147546
74African trypanosomiasis_Homo sapiens_hsa051430.66549488
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65504228
76cAMP signaling pathway_Homo sapiens_hsa040240.64493991
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64412950
78Sulfur metabolism_Homo sapiens_hsa009200.63617652
79RNA degradation_Homo sapiens_hsa030180.62300566
80beta-Alanine metabolism_Homo sapiens_hsa004100.61875542
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.60450765
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58567369
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57244813
84Pancreatic secretion_Homo sapiens_hsa049720.56295512
85Fatty acid biosynthesis_Homo sapiens_hsa000610.55898927
86Thyroid hormone synthesis_Homo sapiens_hsa049180.55549992
87Dilated cardiomyopathy_Homo sapiens_hsa054140.54428798
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.53221027
89Prion diseases_Homo sapiens_hsa050200.50779410
90Butanoate metabolism_Homo sapiens_hsa006500.49904902
91Phagosome_Homo sapiens_hsa041450.46980682
92Purine metabolism_Homo sapiens_hsa002300.46965518
93Dorso-ventral axis formation_Homo sapiens_hsa043200.46621647
94Alcoholism_Homo sapiens_hsa050340.46120596
95Oocyte meiosis_Homo sapiens_hsa041140.44820348
96Tyrosine metabolism_Homo sapiens_hsa003500.44147731
97ErbB signaling pathway_Homo sapiens_hsa040120.44046740
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43185831
99Type I diabetes mellitus_Homo sapiens_hsa049400.42509420
100Asthma_Homo sapiens_hsa053100.42471411
101Fatty acid elongation_Homo sapiens_hsa000620.42380085
102Arachidonic acid metabolism_Homo sapiens_hsa005900.40237610
103Ether lipid metabolism_Homo sapiens_hsa005650.40003839
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39847638
105One carbon pool by folate_Homo sapiens_hsa006700.38596808
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36947712
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36489407
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36340594
109Glucagon signaling pathway_Homo sapiens_hsa049220.36257355
110Phenylalanine metabolism_Homo sapiens_hsa003600.36174780
111Ribosome_Homo sapiens_hsa030100.36032320
112Glycerolipid metabolism_Homo sapiens_hsa005610.34464432
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34355219
114Chemical carcinogenesis_Homo sapiens_hsa052040.33960645
115Graft-versus-host disease_Homo sapiens_hsa053320.32862437
116Pyruvate metabolism_Homo sapiens_hsa006200.31694751
117Glioma_Homo sapiens_hsa052140.31535949
118MAPK signaling pathway_Homo sapiens_hsa040100.30963267
119Retinol metabolism_Homo sapiens_hsa008300.30674116
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30157912
121Proteasome_Homo sapiens_hsa030500.29750061
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29351494
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25700766
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.25041478
125Type II diabetes mellitus_Homo sapiens_hsa049300.24256120
126Metabolic pathways_Homo sapiens_hsa011000.23807425
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23131687
128Ovarian steroidogenesis_Homo sapiens_hsa049130.22696246
129Renal cell carcinoma_Homo sapiens_hsa052110.21673658
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20311269
131Choline metabolism in cancer_Homo sapiens_hsa052310.19757920
132Ras signaling pathway_Homo sapiens_hsa040140.19644161
133Wnt signaling pathway_Homo sapiens_hsa043100.18660352
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18528213
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18514532
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17775098
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.17752120
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15245533
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13195356
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10210889
141Inositol phosphate metabolism_Homo sapiens_hsa005620.09575732
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.09515935

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