AKAP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.43240691
2vocalization behavior (GO:0071625)5.36495755
3synaptic vesicle exocytosis (GO:0016079)5.23448886
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95215034
5neuron cell-cell adhesion (GO:0007158)4.92367121
6protein-cofactor linkage (GO:0018065)4.88611509
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79642382
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.69581135
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.53476261
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47290010
11glutamate secretion (GO:0014047)4.44513118
12regulation of glutamate receptor signaling pathway (GO:1900449)4.42428602
13C4-dicarboxylate transport (GO:0015740)4.38725035
14nucleobase catabolic process (GO:0046113)4.33789958
15proline transport (GO:0015824)4.30911646
16protein localization to synapse (GO:0035418)4.30580747
17neuronal action potential propagation (GO:0019227)4.24566680
18glutamate receptor signaling pathway (GO:0007215)4.19329941
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.11483641
20neurotransmitter-gated ion channel clustering (GO:0072578)4.10470777
21locomotory exploration behavior (GO:0035641)4.05869082
22neurotransmitter secretion (GO:0007269)4.05170477
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.04844508
24gamma-aminobutyric acid transport (GO:0015812)3.98664081
25postsynaptic membrane organization (GO:0001941)3.97010175
26regulation of synaptic vesicle exocytosis (GO:2000300)3.93214516
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.89285488
28presynaptic membrane assembly (GO:0097105)3.89094705
29positive regulation of synapse maturation (GO:0090129)3.87963874
30epithelial cell differentiation involved in kidney development (GO:0035850)3.85855594
31layer formation in cerebral cortex (GO:0021819)3.84293903
32synaptic vesicle maturation (GO:0016188)3.82407689
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.82323607
34neuron-neuron synaptic transmission (GO:0007270)3.82004713
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75348546
36behavioral response to ethanol (GO:0048149)3.75005043
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71015292
38synaptic transmission, glutamatergic (GO:0035249)3.70832931
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.69494542
40cerebellar Purkinje cell differentiation (GO:0021702)3.66988749
41behavioral response to nicotine (GO:0035095)3.65761045
42regulation of synaptic vesicle transport (GO:1902803)3.63516721
43cerebellar granule cell differentiation (GO:0021707)3.58874455
44positive regulation of protein homodimerization activity (GO:0090073)3.58311018
45exploration behavior (GO:0035640)3.57393209
46presynaptic membrane organization (GO:0097090)3.46013512
47glycosphingolipid biosynthetic process (GO:0006688)3.44224296
48regulation of synapse maturation (GO:0090128)3.43479515
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43362457
50neurotransmitter transport (GO:0006836)3.43197810
51regulation of synapse structural plasticity (GO:0051823)3.42496767
52detection of calcium ion (GO:0005513)3.40832112
53DNA double-strand break processing (GO:0000729)3.39617289
54amino acid salvage (GO:0043102)3.38724575
55L-methionine salvage (GO:0071267)3.38724575
56L-methionine biosynthetic process (GO:0071265)3.38724575
57ubiquinone biosynthetic process (GO:0006744)3.37918374
58positive regulation of membrane potential (GO:0045838)3.36278647
59* positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35415458
60negative regulation of oligodendrocyte differentiation (GO:0048715)3.34751053
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.31394752
62regulation of sarcomere organization (GO:0060297)3.31339111
63activation of protein kinase A activity (GO:0034199)3.30959672
64neuron recognition (GO:0008038)3.25038317
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23560293
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23153138
67long-term memory (GO:0007616)3.21070408
68ubiquinone metabolic process (GO:0006743)3.20242812
69cellular potassium ion homeostasis (GO:0030007)3.19359304
70response to histamine (GO:0034776)3.17535709
71organelle disassembly (GO:1903008)3.17168331
72regulation of neurotransmitter levels (GO:0001505)3.16899014
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.15974141
74synapse assembly (GO:0007416)3.13614626
75water-soluble vitamin biosynthetic process (GO:0042364)3.12436994
76regulation of vesicle fusion (GO:0031338)3.12282526
77anterograde synaptic vesicle transport (GO:0048490)3.09081228
78regulation of neuronal synaptic plasticity (GO:0048168)3.07709696
79regulation of postsynaptic membrane potential (GO:0060078)3.07648719
80phenol-containing compound catabolic process (GO:0019336)3.06460113
81regulation of cilium movement (GO:0003352)3.05916022
82regulation of neurotransmitter secretion (GO:0046928)3.05391103
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04834537
84succinate metabolic process (GO:0006105)3.04566284
85cell differentiation in hindbrain (GO:0021533)3.02797202
86positive regulation of mitochondrial fission (GO:0090141)3.01150288
87long-term synaptic potentiation (GO:0060291)3.00059415
88regulation of cAMP-dependent protein kinase activity (GO:2000479)2.99233859
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98593730
90axonal fasciculation (GO:0007413)2.97394902
91ribonucleoprotein complex disassembly (GO:0032988)2.96309444
92neuromuscular synaptic transmission (GO:0007274)2.94249860
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94238671
94membrane hyperpolarization (GO:0060081)2.94203716
95metallo-sulfur cluster assembly (GO:0031163)2.93278635
96iron-sulfur cluster assembly (GO:0016226)2.93278635
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91589377
98synaptic transmission (GO:0007268)2.91449916
99regulation of neurotransmitter transport (GO:0051588)2.90354334
100piRNA metabolic process (GO:0034587)2.89586363
101neurotransmitter catabolic process (GO:0042135)2.88225980
102regulation of voltage-gated calcium channel activity (GO:1901385)2.87882511
103synaptic vesicle endocytosis (GO:0048488)2.87424514
104fear response (GO:0042596)2.86163124
105cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84817756
106protein neddylation (GO:0045116)2.84677745
107membrane depolarization during action potential (GO:0086010)2.84150209
108membrane depolarization (GO:0051899)2.83979219
109startle response (GO:0001964)2.82477878
110glycine transport (GO:0015816)2.82391255
111mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.80636045
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.80636045
113quinone biosynthetic process (GO:1901663)2.79074861
114hippocampus development (GO:0021766)2.78981838
115sequestering of actin monomers (GO:0042989)2.77630374
116positive regulation of synapse assembly (GO:0051965)2.77390297
117negative regulation of hormone biosynthetic process (GO:0032353)2.77123744
118negative regulation of hormone metabolic process (GO:0032351)2.77123744
119neuromuscular process controlling posture (GO:0050884)2.74794916
120sulfation (GO:0051923)2.74461970
121regulation of synaptic plasticity (GO:0048167)2.72382494
122social behavior (GO:0035176)2.72368528
123intraspecies interaction between organisms (GO:0051703)2.72368528
124establishment of mitochondrion localization (GO:0051654)2.71385006
125establishment of synaptic vesicle localization (GO:0097480)2.71101324
126synaptic vesicle transport (GO:0048489)2.71101324
127* positive regulation of potassium ion transmembrane transport (GO:1901381)2.71048706
128regulation of dendritic spine morphogenesis (GO:0061001)2.69991745
129positive regulation of neurotransmitter transport (GO:0051590)2.68498522
130positive regulation of dendritic spine morphogenesis (GO:0061003)2.68310516
131photoreceptor cell maintenance (GO:0045494)2.67995872
132retinal cone cell development (GO:0046549)2.67930523
133neurotransmitter biosynthetic process (GO:0042136)2.67146990
134synapse organization (GO:0050808)2.66720412
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66689873
136nonmotile primary cilium assembly (GO:0035058)2.66667937
137righting reflex (GO:0060013)2.66586955
138indole-containing compound catabolic process (GO:0042436)2.64123471
139indolalkylamine catabolic process (GO:0046218)2.64123471
140tryptophan catabolic process (GO:0006569)2.64123471
141fucose catabolic process (GO:0019317)2.63365676
142L-fucose metabolic process (GO:0042354)2.63365676
143L-fucose catabolic process (GO:0042355)2.63365676
144neurotransmitter metabolic process (GO:0042133)2.62848360
145protein polyglutamylation (GO:0018095)2.61250277
146axoneme assembly (GO:0035082)2.60877270
147detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60739951
148dopamine transport (GO:0015872)2.58162039
149cellular response to leptin stimulus (GO:0044320)2.56702451
150dicarboxylic acid catabolic process (GO:0043649)2.56615882
151activated T cell proliferation (GO:0050798)2.55679031
152acidic amino acid transport (GO:0015800)2.54987955
153regulation of microtubule-based movement (GO:0060632)2.54671077
154indolalkylamine metabolic process (GO:0006586)2.54459469
155methionine biosynthetic process (GO:0009086)2.54207446
156inositol phosphate catabolic process (GO:0071545)2.52585513
157rRNA catabolic process (GO:0016075)2.51181057
158negative regulation of appetite (GO:0032099)2.49802105
159negative regulation of response to food (GO:0032096)2.49802105
160protein K11-linked deubiquitination (GO:0035871)2.48192436
161cellular biogenic amine catabolic process (GO:0042402)2.46677248
162amine catabolic process (GO:0009310)2.46677248
163anterograde axon cargo transport (GO:0008089)2.46554569
164regulation of collateral sprouting (GO:0048670)2.46203528
165tryptophan metabolic process (GO:0006568)2.45818374
166regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45255772
167benzene-containing compound metabolic process (GO:0042537)2.43951748
168negative regulation of DNA-dependent DNA replication (GO:2000104)2.43717550
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42092464
170short-term memory (GO:0007614)2.41672471
171platelet dense granule organization (GO:0060155)2.41583179
172regulation of oligodendrocyte differentiation (GO:0048713)2.38098012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61690500
2GBX2_23144817_ChIP-Seq_PC3_Human4.01862060
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88869091
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86578491
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77669295
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59775960
7TAF15_26573619_Chip-Seq_HEK293_Human2.47128589
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41940092
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41940092
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41775189
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37163259
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34936372
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.33818565
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25188593
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24571438
16REST_21632747_ChIP-Seq_MESCs_Mouse2.23050205
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.18156876
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14623195
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14499215
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06219775
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05176469
22AR_21572438_ChIP-Seq_LNCaP_Human1.94818728
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.93493297
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92145406
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91754878
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91063473
27SMAD4_21799915_ChIP-Seq_A2780_Human1.89541494
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88158823
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87859624
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.81637578
31P300_19829295_ChIP-Seq_ESCs_Human1.81122073
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.79253761
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.78325220
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78271488
35FUS_26573619_Chip-Seq_HEK293_Human1.77214514
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76401802
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76332992
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76311757
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72322070
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67884099
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.67595597
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67081364
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65830751
44CBP_20019798_ChIP-Seq_JUKART_Human1.65830751
45DROSHA_22980978_ChIP-Seq_HELA_Human1.63143313
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60571905
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58995320
48AR_25329375_ChIP-Seq_VCAP_Human1.58754779
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56820659
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54789140
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.54382152
52ZNF274_21170338_ChIP-Seq_K562_Hela1.52663004
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52405672
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52393978
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49392059
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.48138101
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.46954343
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44327285
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41020412
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40378778
61* STAT3_23295773_ChIP-Seq_U87_Human1.38995234
62RNF2_27304074_Chip-Seq_NSC_Mouse1.37889540
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.37866532
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.36756691
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36490484
66* FLI1_21867929_ChIP-Seq_TH2_Mouse1.34690834
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34178292
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33030299
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31713862
70TP53_22573176_ChIP-Seq_HFKS_Human1.31535948
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31245959
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30649520
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.30117884
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29078849
75ER_23166858_ChIP-Seq_MCF-7_Human1.27457703
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27292156
77* TCF4_22108803_ChIP-Seq_LS180_Human1.27135592
78VDR_22108803_ChIP-Seq_LS180_Human1.26002848
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25710182
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25427392
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25316423
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24359826
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.23822228
84* TCF4_23295773_ChIP-Seq_U87_Human1.23712423
85NANOG_19829295_ChIP-Seq_ESCs_Human1.23113624
86SOX2_19829295_ChIP-Seq_ESCs_Human1.23113624
87BCAT_22108803_ChIP-Seq_LS180_Human1.22721491
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.21481152
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21085241
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18859346
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18424904
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17676875
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17622283
94HTT_18923047_ChIP-ChIP_STHdh_Human1.17309098
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.16569693
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.15160926
97P53_22387025_ChIP-Seq_ESCs_Mouse1.14986894
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14956988
99TP53_16413492_ChIP-PET_HCT116_Human1.14793499
100* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14628534
101* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14628534
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13387492
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.13315611
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13173751
105RUNX2_22187159_ChIP-Seq_PCA_Human1.12869986
106ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11739873
107IRF1_19129219_ChIP-ChIP_H3396_Human1.11219409
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.10789730
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.10614976
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09552422
111* JUN_21703547_ChIP-Seq_K562_Human1.08257015
112* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08246952
113* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08200922
114* AR_19668381_ChIP-Seq_PC3_Human1.07645220
115KDM2B_26808549_Chip-Seq_REH_Human1.07573416
116EWS_26573619_Chip-Seq_HEK293_Human1.05813579
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05800755
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05380007
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04817404
120* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03815723
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03134052
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.02380491
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01867248
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01668629
125* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01388522
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99166355
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.98849862
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98401221
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97934119
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.97610854
131* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97588158
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97585048
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94159408
134E2F1_18555785_Chip-Seq_ESCs_Mouse0.93900970
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93793867
136* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93397940
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92981471
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.91852044
139ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90636683
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90485923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.44638918
2MP0002822_catalepsy3.74510887
3MP0003635_abnormal_synaptic_transmissio3.59227330
4MP0004270_analgesia3.39791226
5MP0003880_abnormal_central_pattern3.37534309
6MP0009046_muscle_twitch3.21532327
7MP0009745_abnormal_behavioral_response3.12965830
8MP0002734_abnormal_mechanical_nocicepti2.74938491
9MP0002063_abnormal_learning/memory/cond2.72081835
10MP0002064_seizures2.69934862
11MP0002572_abnormal_emotion/affect_behav2.60839862
12MP0001968_abnormal_touch/_nociception2.57563170
13MP0001501_abnormal_sleep_pattern2.54083395
14MP0002272_abnormal_nervous_system2.42207398
15MP0001440_abnormal_grooming_behavior2.33618875
16MP0001486_abnormal_startle_reflex2.33073070
17MP0006276_abnormal_autonomic_nervous2.26538235
18MP0010386_abnormal_urinary_bladder2.21079361
19MP0005386_behavior/neurological_phenoty2.08820346
20MP0004924_abnormal_behavior2.08820346
21MP0002067_abnormal_sensory_capabilities2.04728571
22MP0002638_abnormal_pupillary_reflex2.01185544
23MP0002736_abnormal_nociception_after2.00489775
24MP0002733_abnormal_thermal_nociception1.95492447
25MP0005084_abnormal_gallbladder_morpholo1.94832259
26MP0005423_abnormal_somatic_nervous1.91388512
27MP0002837_dystrophic_cardiac_calcinosis1.86910860
28MP0002735_abnormal_chemical_nociception1.86577916
29MP0001970_abnormal_pain_threshold1.86171320
30MP0001986_abnormal_taste_sensitivity1.86018705
31MP0003787_abnormal_imprinting1.82631789
32MP0001905_abnormal_dopamine_level1.80662788
33MP0008569_lethality_at_weaning1.79736160
34MP0004215_abnormal_myocardial_fiber1.78509161
35MP0005646_abnormal_pituitary_gland1.77066120
36MP0003646_muscle_fatigue1.72799794
37MP0009780_abnormal_chondrocyte_physiolo1.70050511
38MP0002557_abnormal_social/conspecific_i1.68631829
39MP0002277_abnormal_respiratory_mucosa1.66589379
40MP0002184_abnormal_innervation1.65830332
41MP0003879_abnormal_hair_cell1.63526018
42MP0004147_increased_porphyrin_level1.62324336
43MP0008875_abnormal_xenobiotic_pharmacok1.57370658
44MP0000778_abnormal_nervous_system1.51294154
45MP0001529_abnormal_vocalization1.50832432
46MP0001188_hyperpigmentation1.48797535
47MP0001984_abnormal_olfaction1.44149198
48MP0003121_genomic_imprinting1.42900719
49MP0004484_altered_response_of1.42601747
50MP0004043_abnormal_pH_regulation1.41186321
51MP0005253_abnormal_eye_physiology1.40464597
52MP0001502_abnormal_circadian_rhythm1.36835588
53MP0000751_myopathy1.32918439
54MP0002909_abnormal_adrenal_gland1.32818461
55MP0003195_calcinosis1.31054903
56MP0004145_abnormal_muscle_electrophysio1.30332931
57MP0003136_yellow_coat_color1.28002376
58MP0003011_delayed_dark_adaptation1.27140584
59MP0008872_abnormal_physiological_respon1.26930126
60MP0002066_abnormal_motor_capabilities/c1.26722402
61MP0006035_abnormal_mitochondrial_morpho1.25217031
62MP0005551_abnormal_eye_electrophysiolog1.22971671
63MP0005394_taste/olfaction_phenotype1.19809488
64MP0005499_abnormal_olfactory_system1.19809488
65MP0002102_abnormal_ear_morphology1.19049156
66MP0008789_abnormal_olfactory_epithelium1.14145464
67MP0002882_abnormal_neuron_morphology1.14071594
68MP0001270_distended_abdomen1.11198744
69MP0003329_amyloid_beta_deposits1.10338126
70MP0004811_abnormal_neuron_physiology1.09606925
71MP0000013_abnormal_adipose_tissue1.09185805
72MP0004885_abnormal_endolymph1.09108995
73MP0003633_abnormal_nervous_system1.08435422
74MP0004142_abnormal_muscle_tone1.08072064
75MP0008058_abnormal_DNA_repair1.07964187
76MP0005645_abnormal_hypothalamus_physiol1.07846992
77MP0002332_abnormal_exercise_endurance1.07526471
78MP0005171_absent_coat_pigmentation1.07181640
79MP0006072_abnormal_retinal_apoptosis1.05428858
80MP0006036_abnormal_mitochondrial_physio1.04874386
81MP0000955_abnormal_spinal_cord1.03956314
82MP0004085_abnormal_heartbeat1.02179870
83MP0004858_abnormal_nervous_system1.01329770
84MP0004130_abnormal_muscle_cell1.00333567
85MP0003122_maternal_imprinting0.99269144
86MP0003631_nervous_system_phenotype0.98988301
87MP0001664_abnormal_digestion0.98411424
88MP0004233_abnormal_muscle_weight0.96820110
89MP0004742_abnormal_vestibular_system0.94244626
90MP0002876_abnormal_thyroid_physiology0.91895782
91MP0005535_abnormal_body_temperature0.91360353
92MP0010329_abnormal_lipoprotein_level0.91229412
93MP0001963_abnormal_hearing_physiology0.91144467
94MP0000538_abnormal_urinary_bladder0.90892870
95MP0002152_abnormal_brain_morphology0.90385122
96MP0003137_abnormal_impulse_conducting0.90163373
97MP0001764_abnormal_homeostasis0.90037853
98MP0000230_abnormal_systemic_arterial0.89665016
99MP0002653_abnormal_ependyma_morphology0.88710750
100MP0000049_abnormal_middle_ear0.86809442
101MP0005379_endocrine/exocrine_gland_phen0.84851573
102MP0005187_abnormal_penis_morphology0.84178532
103MP0001485_abnormal_pinna_reflex0.83673957
104MP0003698_abnormal_male_reproductive0.82887696
105MP0001929_abnormal_gametogenesis0.80484196
106MP0002069_abnormal_eating/drinking_beha0.79439244
107MP0005620_abnormal_muscle_contractility0.79392241
108MP0002138_abnormal_hepatobiliary_system0.78971313
109MP0002752_abnormal_somatic_nervous0.78622844
110MP0009379_abnormal_foot_pigmentation0.77311973
111MP0006138_congestive_heart_failure0.77118466
112MP0002229_neurodegeneration0.76389483
113MP0002972_abnormal_cardiac_muscle0.75015365
114MP0002163_abnormal_gland_morphology0.74974149
115MP0005365_abnormal_bile_salt0.74052600
116MP0003724_increased_susceptibility_to0.73681235
117MP0002090_abnormal_vision0.73469212
118MP0002233_abnormal_nose_morphology0.71231567
119MP0001177_atelectasis0.71119426
120MP0000465_gastrointestinal_hemorrhage0.69917009
121MP0004133_heterotaxia0.69803066
122MP0000631_abnormal_neuroendocrine_gland0.69468922
123MP0003632_abnormal_nervous_system0.69324262
124MP0008874_decreased_physiological_sensi0.68281449
125MP0004036_abnormal_muscle_relaxation0.65814830
126MP0006292_abnormal_olfactory_placode0.65260960
127MP0008877_abnormal_DNA_methylation0.64747935
128MP0005367_renal/urinary_system_phenotyp0.64716801
129MP0000516_abnormal_urinary_system0.64716801
130MP0000569_abnormal_digit_pigmentation0.64392519
131MP0000026_abnormal_inner_ear0.62816521
132MP0000372_irregular_coat_pigmentation0.60599198

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78654190
2Focal seizures (HP:0007359)5.21734653
3Atonic seizures (HP:0010819)5.15990329
4Epileptic encephalopathy (HP:0200134)4.87637093
5Febrile seizures (HP:0002373)4.86706978
6Visual hallucinations (HP:0002367)4.79430265
7Hypothermia (HP:0002045)4.56592106
8Progressive cerebellar ataxia (HP:0002073)4.56066386
9Myokymia (HP:0002411)4.23816677
10Hyperventilation (HP:0002883)3.97462844
11Absence seizures (HP:0002121)3.94113566
12Generalized tonic-clonic seizures (HP:0002069)3.66536624
13Dialeptic seizures (HP:0011146)3.59564053
14Action tremor (HP:0002345)3.56089192
15Progressive inability to walk (HP:0002505)3.49790867
16Abnormality of the labia minora (HP:0012880)3.45876883
17Broad-based gait (HP:0002136)3.42402692
18Gaze-evoked nystagmus (HP:0000640)3.34222598
19Limb dystonia (HP:0002451)3.23725683
20Amblyopia (HP:0000646)3.10698352
21Genetic anticipation (HP:0003743)3.10208517
22Split foot (HP:0001839)3.01727409
23Inability to walk (HP:0002540)2.93632459
24Poor eye contact (HP:0000817)2.92412460
25Pancreatic cysts (HP:0001737)2.90290814
26Dysdiadochokinesis (HP:0002075)2.89030304
27Hyperglycinemia (HP:0002154)2.87060347
28Pheochromocytoma (HP:0002666)2.85416441
29Gait imbalance (HP:0002141)2.84691017
30Lissencephaly (HP:0001339)2.69871336
31Ankle clonus (HP:0011448)2.68041250
32Diplopia (HP:0000651)2.64978765
33Abnormality of binocular vision (HP:0011514)2.64978765
34Type II lissencephaly (HP:0007260)2.63759528
35Absent speech (HP:0001344)2.61454653
36Anxiety (HP:0000739)2.60765819
37Abnormality of glycine metabolism (HP:0010895)2.60505715
38Abnormality of serine family amino acid metabolism (HP:0010894)2.60505715
39Congenital stationary night blindness (HP:0007642)2.58346195
40Abnormal social behavior (HP:0012433)2.58241642
41Impaired social interactions (HP:0000735)2.58241642
42Pachygyria (HP:0001302)2.57892064
43Hemiparesis (HP:0001269)2.54916037
44Dysmetric saccades (HP:0000641)2.53937798
45Hyperglycinuria (HP:0003108)2.51560007
46Abnormal eating behavior (HP:0100738)2.50738464
47Decreased central vision (HP:0007663)2.49305322
48Neuroendocrine neoplasm (HP:0100634)2.48227966
49Polyphagia (HP:0002591)2.47742072
50Abolished electroretinogram (ERG) (HP:0000550)2.44725737
51Excessive salivation (HP:0003781)2.42583830
52Drooling (HP:0002307)2.42583830
53Congenital primary aphakia (HP:0007707)2.39732526
54True hermaphroditism (HP:0010459)2.39146973
55Renal cortical cysts (HP:0000803)2.34619644
56Lipid accumulation in hepatocytes (HP:0006561)2.34470771
573-Methylglutaconic aciduria (HP:0003535)2.33144110
58Acute encephalopathy (HP:0006846)2.33067887
59Amyotrophic lateral sclerosis (HP:0007354)2.32515788
60Failure to thrive in infancy (HP:0001531)2.29302259
61Retinal dysplasia (HP:0007973)2.26711262
62Fetal akinesia sequence (HP:0001989)2.24451805
63Hyperthyroidism (HP:0000836)2.24164951
64Pancreatic fibrosis (HP:0100732)2.23769638
65Abnormality of midbrain morphology (HP:0002418)2.22120358
66Molar tooth sign on MRI (HP:0002419)2.22120358
67Epileptiform EEG discharges (HP:0011182)2.21241068
68Depression (HP:0000716)2.20545200
69Dysmetria (HP:0001310)2.20406867
70Abnormality of the renal cortex (HP:0011035)2.16627523
71Scanning speech (HP:0002168)2.15772437
72Colon cancer (HP:0003003)2.14177713
73Nephrogenic diabetes insipidus (HP:0009806)2.14100707
74Progressive macrocephaly (HP:0004481)2.13589993
75Oligomenorrhea (HP:0000876)2.13144545
76Medial flaring of the eyebrow (HP:0010747)2.12779171
77Horizontal nystagmus (HP:0000666)2.12389694
78Spastic tetraplegia (HP:0002510)2.11917741
79Truncal ataxia (HP:0002078)2.11181826
80Impaired smooth pursuit (HP:0007772)2.09989224
81Impaired vibration sensation in the lower limbs (HP:0002166)2.09971025
82Abnormal hair whorl (HP:0010721)2.09669177
83Generalized hypopigmentation of hair (HP:0011358)2.09602603
84EEG with generalized epileptiform discharges (HP:0011198)2.07431166
85Urinary bladder sphincter dysfunction (HP:0002839)2.06527348
86Urinary urgency (HP:0000012)2.05474387
87Pendular nystagmus (HP:0012043)2.04017037
88Syncope (HP:0001279)2.03646920
89Fair hair (HP:0002286)2.03541077
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03391525
91Increased CSF lactate (HP:0002490)2.03083395
92Blue irides (HP:0000635)2.03035471
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02346392
94Abnormality of alanine metabolism (HP:0010916)2.02346392
95Hyperalaninemia (HP:0003348)2.02346392
96Specific learning disability (HP:0001328)2.00959454
97Acute necrotizing encephalopathy (HP:0006965)2.00804173
98Abnormal mitochondria in muscle tissue (HP:0008316)1.98783744
99Protruding tongue (HP:0010808)1.98753490
100Cerebral edema (HP:0002181)1.96989048
101Hemiplegia (HP:0002301)1.95881280
102Narrow nasal bridge (HP:0000446)1.94973151
103Increased hepatocellular lipid droplets (HP:0006565)1.94430079
104Nonprogressive disorder (HP:0003680)1.94071389
105Myotonia (HP:0002486)1.94069491
106Mitochondrial inheritance (HP:0001427)1.93732885
107Exotropia (HP:0000577)1.91569789
108Rimmed vacuoles (HP:0003805)1.90593101
109Hypsarrhythmia (HP:0002521)1.89879160
110Genital tract atresia (HP:0001827)1.89743840
111Prolonged QT interval (HP:0001657)1.89594021
112Hepatocellular necrosis (HP:0001404)1.89322005
113Neoplasm of the peripheral nervous system (HP:0100007)1.88768714
114Exercise-induced myalgia (HP:0003738)1.86397449
115Neonatal hypoglycemia (HP:0001998)1.85436010
116Methylmalonic acidemia (HP:0002912)1.85412976
117Stereotypic behavior (HP:0000733)1.85371092
118Status epilepticus (HP:0002133)1.85228320
119Ventricular fibrillation (HP:0001663)1.85219049
120Muscular hypotonia of the trunk (HP:0008936)1.83982236
121Abnormal rod and cone electroretinograms (HP:0008323)1.83936605
122Dynein arm defect of respiratory motile cilia (HP:0012255)1.83881313
123Absent/shortened dynein arms (HP:0200106)1.83881313
124Abnormality of ocular smooth pursuit (HP:0000617)1.83860333
125Agitation (HP:0000713)1.83838446
126Poor coordination (HP:0002370)1.83276379
127Cerebral hypomyelination (HP:0006808)1.80067508
128Vaginal atresia (HP:0000148)1.79653499
129Poor suck (HP:0002033)1.79174306
130Abnormal protein glycosylation (HP:0012346)1.78099152
131Abnormal glycosylation (HP:0012345)1.78099152
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78099152
133Abnormal protein N-linked glycosylation (HP:0012347)1.78099152
134Volvulus (HP:0002580)1.77871106
135Aplasia/Hypoplasia of the lens (HP:0008063)1.77455930
136Mutism (HP:0002300)1.77393808
137Stomach cancer (HP:0012126)1.77089513
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.76815187
139Abnormality of the corticospinal tract (HP:0002492)1.75562392
140Nephronophthisis (HP:0000090)1.75297130
141Abnormal EKG (HP:0003115)1.74651368
142Bile duct proliferation (HP:0001408)1.74579979
143Abnormal biliary tract physiology (HP:0012439)1.74579979
144Esotropia (HP:0000565)1.74541212
145Spastic gait (HP:0002064)1.74539847
146Optic disc pallor (HP:0000543)1.74037535
147Impaired vibratory sensation (HP:0002495)1.72889192
148Lethargy (HP:0001254)1.72658018
149Postural tremor (HP:0002174)1.72636674
150Atrial fibrillation (HP:0005110)1.72627218
151Primary atrial arrhythmia (HP:0001692)1.72543570
152Inappropriate behavior (HP:0000719)1.72151053
153Left ventricular hypertrophy (HP:0001712)1.70671814
154Papillary thyroid carcinoma (HP:0002895)1.67924541
155Gait ataxia (HP:0002066)1.67217343
156Bradykinesia (HP:0002067)1.67160392
157Enlarged penis (HP:0000040)1.66958984
158Bradycardia (HP:0001662)1.66901793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.77508083
2MAP3K123.37212103
3MAP3K43.35142987
4NTRK33.34111749
5MAP2K73.27848833
6MAP4K23.09433487
7WNK33.05381564
8MARK12.68819345
9MUSK2.63488721
10MAP3K92.59300015
11EPHA42.26315251
12TRIM282.25610677
13BCR2.13298012
14MAP2K42.07780562
15TAOK32.07012201
16LMTK22.06983353
17MAPK131.91082882
18TNIK1.89568639
19MAP3K61.87123349
20STK38L1.86608763
21NUAK11.84429983
22CAMKK21.78053344
23GRK51.72574228
24KSR21.69970386
25DAPK21.68771099
26NTRK21.59151109
27MINK11.57820446
28NTRK11.53962498
29CDK191.53344019
30ARAF1.53010359
31RIPK41.50811420
32CSNK1G11.49348828
33OBSCN1.44564213
34VRK11.41911444
35ERBB31.39994848
36PLK21.37870185
37PAK61.32239788
38LATS21.32095898
39ERBB41.31944008
40ZAK1.28683191
41FRK1.26643972
42CSNK1A1L1.24598416
43SGK21.24142829
44PHKG11.24010388
45PHKG21.24010388
46GRK71.19351999
47TIE11.17766335
48GRK11.13649165
49BCKDK1.13245264
50DAPK11.12776295
51PIK3CA1.08665567
52CAMKK11.08501045
53CAMK2A1.05015340
54PDK41.03913290
55PDK31.03913290
56CAMK1G1.03474128
57CDK51.01331271
58KSR11.00833500
59CDK80.99180658
60BMPR1B0.97753873
61CCNB10.97689976
62EPHA30.97115270
63MKNK20.96220446
64PRKCE0.95449258
65BMPR20.94549113
66PNCK0.93566274
67SGK4940.92605706
68SGK2230.92605706
69MAP3K130.92364143
70CAMK10.91780860
71TXK0.90912858
72RAF10.90187347
73MAPKAPK50.89030309
74PRKCG0.88331171
75MYLK0.85166100
76RPS6KA40.84406704
77CSNK1G20.84320461
78UHMK10.79939564
79MAPK70.76449422
80GRK60.76375472
81OXSR10.75864169
82AKT30.74959070
83INSRR0.74748187
84MAP2K10.74352481
85CAMK1D0.73861715
86BRAF0.70852010
87PRPF4B0.70754497
88FGFR20.69634662
89PLK30.68227547
90SRPK10.67576952
91RET0.67154125
92SGK30.67052574
93STK110.66604719
94CAMK2B0.66286223
95ADRBK20.65448801
96ACVR1B0.63381016
97STK380.61948110
98PRKCZ0.59172077
99DYRK1A0.58800535
100SIK20.57960209
101SGK10.57807859
102ADRBK10.57402928
103MAP3K50.56165829
104DYRK30.56111310
105CAMK2D0.55284878
106FGR0.55238315
107MAPK120.54637912
108SYK0.54617676
109FES0.53823600
110MAP3K20.53353304
111CDK30.53282092
112PTK2B0.52685787
113CSNK1D0.51838539
114CDK180.51691014
115RPS6KA50.51450457
116CDK150.51301641
117TEC0.50263882
118PKN10.50144257
119PRKD30.50129016
120PRKAA20.49221829
121PINK10.48698848
122CAMK2G0.47630577
123MARK20.46723957
124CSF1R0.46554240
125CDK140.45077707
126DYRK20.44070483
127CAMK40.43976407
128CDK11A0.43102709
129NEK60.42483534
130PRKACA0.40904856
131RIPK10.40635584
132CSNK1G30.39432031
133IGF1R0.39000865
134PRKCQ0.38337593
135LIMK10.38209916
136PDK20.37423735
137PRKG10.36997799
138MATK0.36719807
139TYRO30.36586120
140CSNK1A10.36284883
141PAK30.35481163
142PRKACG0.35090802
143PRKCA0.32713768
144PRKACB0.30903043
145STK160.29267655
146CSNK1E0.28706187

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77106011
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97137433
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87161338
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.76589025
5Circadian entrainment_Homo sapiens_hsa047132.62733260
6GABAergic synapse_Homo sapiens_hsa047272.60884900
7Glutamatergic synapse_Homo sapiens_hsa047242.50293455
8Morphine addiction_Homo sapiens_hsa050322.44846774
9Long-term potentiation_Homo sapiens_hsa047202.31239065
10Olfactory transduction_Homo sapiens_hsa047402.25579922
11Amphetamine addiction_Homo sapiens_hsa050312.23147022
12Salivary secretion_Homo sapiens_hsa049702.19760795
13Long-term depression_Homo sapiens_hsa047302.11814458
14Taste transduction_Homo sapiens_hsa047422.07639651
15Serotonergic synapse_Homo sapiens_hsa047262.05617236
16Dopaminergic synapse_Homo sapiens_hsa047282.05415288
17Cholinergic synapse_Homo sapiens_hsa047251.95003216
18Insulin secretion_Homo sapiens_hsa049111.89630743
19Renin secretion_Homo sapiens_hsa049241.83754625
20Collecting duct acid secretion_Homo sapiens_hsa049661.83449162
21Gastric acid secretion_Homo sapiens_hsa049711.77758649
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73217305
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72643199
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71987145
25beta-Alanine metabolism_Homo sapiens_hsa004101.68213345
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67460325
27Oxytocin signaling pathway_Homo sapiens_hsa049211.62393889
28Oxidative phosphorylation_Homo sapiens_hsa001901.59287050
29Linoleic acid metabolism_Homo sapiens_hsa005911.58531115
30Calcium signaling pathway_Homo sapiens_hsa040201.57266036
31Nitrogen metabolism_Homo sapiens_hsa009101.56581618
32Cocaine addiction_Homo sapiens_hsa050301.55909716
33Propanoate metabolism_Homo sapiens_hsa006401.54138920
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50374795
35GnRH signaling pathway_Homo sapiens_hsa049121.47481883
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42955465
37Cardiac muscle contraction_Homo sapiens_hsa042601.42302370
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41743803
39Tryptophan metabolism_Homo sapiens_hsa003801.41436129
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40479550
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38717729
42Gap junction_Homo sapiens_hsa045401.33323476
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30838937
44Selenocompound metabolism_Homo sapiens_hsa004501.30752178
45cAMP signaling pathway_Homo sapiens_hsa040241.28058533
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26079610
47Alzheimers disease_Homo sapiens_hsa050101.23851948
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23218691
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.21519686
50Parkinsons disease_Homo sapiens_hsa050121.21283577
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.20373723
52Basal transcription factors_Homo sapiens_hsa030221.18778254
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18191754
54Pancreatic secretion_Homo sapiens_hsa049721.18010905
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17285926
56Peroxisome_Homo sapiens_hsa041461.14925742
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13801653
58Regulation of autophagy_Homo sapiens_hsa041401.11770223
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11597158
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11583002
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.09759962
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09129965
63Estrogen signaling pathway_Homo sapiens_hsa049151.07876814
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04620172
65Vibrio cholerae infection_Homo sapiens_hsa051101.03835457
66Circadian rhythm_Homo sapiens_hsa047101.03723366
67Ovarian steroidogenesis_Homo sapiens_hsa049131.02922459
68Protein export_Homo sapiens_hsa030601.01599366
69Fatty acid elongation_Homo sapiens_hsa000621.01355455
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00565268
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99610630
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99505478
73Fatty acid degradation_Homo sapiens_hsa000710.99031957
74Retinol metabolism_Homo sapiens_hsa008300.98750133
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98375815
76Caffeine metabolism_Homo sapiens_hsa002320.94673279
77Ether lipid metabolism_Homo sapiens_hsa005650.94061659
78Chemical carcinogenesis_Homo sapiens_hsa052040.93913396
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93290467
80Melanogenesis_Homo sapiens_hsa049160.93068181
81Fatty acid metabolism_Homo sapiens_hsa012120.92903859
82Huntingtons disease_Homo sapiens_hsa050160.92686358
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90995419
84Phototransduction_Homo sapiens_hsa047440.88445945
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88170409
86RNA polymerase_Homo sapiens_hsa030200.87721041
87Dilated cardiomyopathy_Homo sapiens_hsa054140.87608438
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86170698
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85507111
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84983636
91Type II diabetes mellitus_Homo sapiens_hsa049300.84254598
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83222905
93RNA degradation_Homo sapiens_hsa030180.80890833
94Thyroid hormone synthesis_Homo sapiens_hsa049180.79096174
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.76690072
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75671073
97ErbB signaling pathway_Homo sapiens_hsa040120.75188297
98Oocyte meiosis_Homo sapiens_hsa041140.74586347
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72051362
100Dorso-ventral axis formation_Homo sapiens_hsa043200.70491285
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69648059
102Axon guidance_Homo sapiens_hsa043600.68035260
103Butanoate metabolism_Homo sapiens_hsa006500.67618230
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.64600723
105Glucagon signaling pathway_Homo sapiens_hsa049220.64020893
106Choline metabolism in cancer_Homo sapiens_hsa052310.62513454
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.62186222
108Glioma_Homo sapiens_hsa052140.61806274
109Glycerolipid metabolism_Homo sapiens_hsa005610.61389649
110Fat digestion and absorption_Homo sapiens_hsa049750.58351756
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57711249
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55839495
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53970029
114Metabolic pathways_Homo sapiens_hsa011000.53227822
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52233225
116Arachidonic acid metabolism_Homo sapiens_hsa005900.51919130
117Ras signaling pathway_Homo sapiens_hsa040140.51764750
118MAPK signaling pathway_Homo sapiens_hsa040100.49798264
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49705239
120Fatty acid biosynthesis_Homo sapiens_hsa000610.48836625
121Histidine metabolism_Homo sapiens_hsa003400.48084242
122Steroid biosynthesis_Homo sapiens_hsa001000.47983733
123Inositol phosphate metabolism_Homo sapiens_hsa005620.45994129
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45212990
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44777693
126African trypanosomiasis_Homo sapiens_hsa051430.43504308
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42971730
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42766505
129Alcoholism_Homo sapiens_hsa050340.42276087
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41391614
131Purine metabolism_Homo sapiens_hsa002300.41345371
132Sulfur metabolism_Homo sapiens_hsa009200.40503309
133Arginine and proline metabolism_Homo sapiens_hsa003300.39253679
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.39090622
135Bile secretion_Homo sapiens_hsa049760.38659888
136Rheumatoid arthritis_Homo sapiens_hsa053230.37267663
137Rap1 signaling pathway_Homo sapiens_hsa040150.37153415
138ABC transporters_Homo sapiens_hsa020100.37089374
139Melanoma_Homo sapiens_hsa052180.36150191
140Mineral absorption_Homo sapiens_hsa049780.35286263
141Fanconi anemia pathway_Homo sapiens_hsa034600.34690016
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33043229
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32607555
144Proteasome_Homo sapiens_hsa030500.31193074
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31002805
146Pyruvate metabolism_Homo sapiens_hsa006200.30585861
147Platelet activation_Homo sapiens_hsa046110.29499959
148Insulin signaling pathway_Homo sapiens_hsa049100.28084368
149Endometrial cancer_Homo sapiens_hsa052130.27316670
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26970458
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.25046392
152Wnt signaling pathway_Homo sapiens_hsa043100.22735724

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