AKAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.02657193
2nuclear pore complex assembly (GO:0051292)4.96649666
3nuclear pore organization (GO:0006999)4.85200906
4mitotic sister chromatid cohesion (GO:0007064)4.53116927
5protein localization to kinetochore (GO:0034501)4.42946751
6DNA unwinding involved in DNA replication (GO:0006268)4.22243285
7regulation of retinoic acid receptor signaling pathway (GO:0048385)4.19918946
8negative regulation of histone methylation (GO:0031061)4.11383348
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06600715
10mitotic metaphase plate congression (GO:0007080)4.05098733
11pre-miRNA processing (GO:0031054)4.01618634
12protein localization to chromosome, centromeric region (GO:0071459)3.89155010
13positive regulation of gamma-delta T cell activation (GO:0046645)3.86445148
14pore complex assembly (GO:0046931)3.83359015
15regulation of RNA export from nucleus (GO:0046831)3.81663455
16mitotic nuclear envelope disassembly (GO:0007077)3.79082645
17regulation of spindle organization (GO:0090224)3.72812813
18negative regulation of RNA splicing (GO:0033119)3.70035530
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68723562
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64673021
21DNA replication initiation (GO:0006270)3.64439440
22metaphase plate congression (GO:0051310)3.62473192
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.60084776
24DNA duplex unwinding (GO:0032508)3.55919181
25DNA replication checkpoint (GO:0000076)3.55634473
26* mitotic chromosome condensation (GO:0007076)3.53727293
27nuclear envelope disassembly (GO:0051081)3.53585569
28membrane disassembly (GO:0030397)3.53585569
29DNA geometric change (GO:0032392)3.52663698
30regulation of histone H3-K9 methylation (GO:0051570)3.52280895
31negative regulation of mRNA processing (GO:0050686)3.50866765
32nucleobase biosynthetic process (GO:0046112)3.44700298
33regulation of mitotic spindle organization (GO:0060236)3.41791471
34kinetochore organization (GO:0051383)3.40918703
35regulation of histone H3-K27 methylation (GO:0061085)3.37555641
36sister chromatid segregation (GO:0000819)3.36723498
37mitotic sister chromatid segregation (GO:0000070)3.36456479
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35340068
39negative regulation of cell killing (GO:0031342)3.35340068
40regulation of sister chromatid cohesion (GO:0007063)3.35252466
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.33273015
42positive regulation of granulocyte differentiation (GO:0030854)3.32667574
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.30893362
44DNA strand elongation involved in DNA replication (GO:0006271)3.26811690
45response to muramyl dipeptide (GO:0032495)3.25760375
46dosage compensation (GO:0007549)3.23111864
47IMP biosynthetic process (GO:0006188)3.22601906
48negative regulation of erythrocyte differentiation (GO:0045647)3.21449094
49alternative mRNA splicing, via spliceosome (GO:0000380)3.15523716
50purine nucleobase biosynthetic process (GO:0009113)3.15312886
51DNA replication-independent nucleosome assembly (GO:0006336)3.14344431
52DNA replication-independent nucleosome organization (GO:0034724)3.14344431
53chromatin assembly or disassembly (GO:0006333)3.13067976
54monoubiquitinated protein deubiquitination (GO:0035520)3.12810145
55negative regulation of T cell mediated immunity (GO:0002710)3.12749416
56ribosome biogenesis (GO:0042254)3.12692424
57DNA strand elongation (GO:0022616)3.12588258
58positive regulation of chromosome segregation (GO:0051984)3.12392278
59negative regulation of mRNA metabolic process (GO:1903312)3.11162923
60regulation of gamma-delta T cell activation (GO:0046643)3.10531843
61protein localization to chromosome (GO:0034502)3.10330131
62DNA replication-dependent nucleosome assembly (GO:0006335)3.07390173
63DNA replication-dependent nucleosome organization (GO:0034723)3.07390173
64regulation of gamma-delta T cell differentiation (GO:0045586)3.06740270
65RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.06728015
66mRNA splicing, via spliceosome (GO:0000398)3.06728015
67maturation of SSU-rRNA (GO:0030490)3.05759686
68RNA splicing, via transesterification reactions (GO:0000375)3.03157201
69regulation of helicase activity (GO:0051095)3.02850037
70histone H3-K36 demethylation (GO:0070544)3.02111151
71formation of translation preinitiation complex (GO:0001731)3.01025498
72regulation of granulocyte differentiation (GO:0030852)3.00927387
73histone H4-K8 acetylation (GO:0043982)3.00771383
74histone H4-K5 acetylation (GO:0043981)3.00771383
75ribosome assembly (GO:0042255)3.00628125
76translesion synthesis (GO:0019985)3.00537299
77histone H2A monoubiquitination (GO:0035518)2.99248333
78establishment of chromosome localization (GO:0051303)2.98731948
79positive regulation of protein homooligomerization (GO:0032464)2.98630814
80positive T cell selection (GO:0043368)2.97672474
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97269328
82kinetochore assembly (GO:0051382)2.96981760
83regulation of histone methylation (GO:0031060)2.96459692
84histone H3-K4 trimethylation (GO:0080182)2.95444537
853-UTR-mediated mRNA stabilization (GO:0070935)2.95290652
86mRNA splice site selection (GO:0006376)2.94991337
87histone H4-K16 acetylation (GO:0043984)2.93156849
88mitotic G1 DNA damage checkpoint (GO:0031571)2.92805554
89histone H3-K4 methylation (GO:0051568)2.92360114
90histone mRNA catabolic process (GO:0071044)2.92209695
91regulation of DNA endoreduplication (GO:0032875)2.91747619
92* DNA conformation change (GO:0071103)2.91316616
93regulation of nucleobase-containing compound transport (GO:0032239)2.91031661
94termination of RNA polymerase II transcription (GO:0006369)2.90998562
95ribosomal small subunit biogenesis (GO:0042274)2.90543756
96ATP-dependent chromatin remodeling (GO:0043044)2.90100498
97regulation of chromosome segregation (GO:0051983)2.89998224
98mRNA transport (GO:0051028)2.89996921
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.89041980
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.88522930
101mRNA export from nucleus (GO:0006406)2.88208164
102nuclear envelope organization (GO:0006998)2.88186178
103T cell selection (GO:0045058)2.87887481
104CENP-A containing nucleosome assembly (GO:0034080)2.86536575
105RNA export from nucleus (GO:0006405)2.86390772
106IMP metabolic process (GO:0046040)2.85437732
107RNA stabilization (GO:0043489)2.85381600
108mRNA stabilization (GO:0048255)2.85381600
109chromatin remodeling at centromere (GO:0031055)2.83068862
110regulation of DNA damage checkpoint (GO:2000001)2.82098814
111CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81855156
112histone H4-K12 acetylation (GO:0043983)2.81041210
113telomere maintenance via semi-conservative replication (GO:0032201)2.80188609
114positive thymic T cell selection (GO:0045059)2.79788206
115cellular response to virus (GO:0098586)2.79151814
116negative regulation of interleukin-12 production (GO:0032695)2.78670001
117chromatin assembly (GO:0031497)2.78276933
118intra-S DNA damage checkpoint (GO:0031573)2.77003744
119sister chromatid cohesion (GO:0007062)2.76052332
120positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.75217425
121snRNA metabolic process (GO:0016073)2.74897891
122spliceosomal tri-snRNP complex assembly (GO:0000244)2.74822853
123DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.74567384
124negative thymic T cell selection (GO:0045060)2.74506567
125interferon-gamma production (GO:0032609)2.71456150
126meiotic chromosome segregation (GO:0045132)2.70753044
127negative regulation of granulocyte differentiation (GO:0030853)2.67247446
128negative T cell selection (GO:0043383)2.67222291
129Peyers patch development (GO:0048541)2.64473276
130mucosal-associated lymphoid tissue development (GO:0048537)2.64473276
131cellular response to dsRNA (GO:0071359)2.64083036
132ribonucleoprotein complex biogenesis (GO:0022613)2.60841462
133regulation of gene silencing by RNA (GO:0060966)2.59452479
134regulation of posttranscriptional gene silencing (GO:0060147)2.59452479
135regulation of gene silencing by miRNA (GO:0060964)2.59452479
136RNA methylation (GO:0001510)2.59450740
137response to peptidoglycan (GO:0032494)2.58223549
138regulation of B cell receptor signaling pathway (GO:0050855)2.56981487
139tolerance induction (GO:0002507)2.56818058
140negative regulation of cell cycle G2/M phase transition (GO:1902750)2.55618099
141histone lysine methylation (GO:0034968)2.54340045
142regulation of alpha-beta T cell proliferation (GO:0046640)2.53817712
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53281731
144mannose metabolic process (GO:0006013)2.51864797
145negative regulation of viral release from host cell (GO:1902187)2.51801420
146germinal center formation (GO:0002467)2.50957849
147rRNA catabolic process (GO:0016075)2.49995012
148regulation of cell cycle checkpoint (GO:1901976)2.48937974
149thymic T cell selection (GO:0045061)2.48394803
150leukocyte aggregation (GO:0070486)2.48131287
151regulation of B cell differentiation (GO:0045577)2.45980349
152ncRNA 3-end processing (GO:0043628)2.44579419
153peptidyl-lysine trimethylation (GO:0018023)2.42546484
154positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42458777
155positive regulation of DNA-templated transcription, elongation (GO:0032786)2.42402676
156positive regulation of T-helper 1 type immune response (GO:0002827)2.42356961
157positive regulation of defense response to virus by host (GO:0002230)2.41538685
158T cell migration (GO:0072678)2.41521213
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.40641506
160N-terminal protein amino acid acetylation (GO:0006474)2.40290530
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40009193
162positive regulation of T cell differentiation in thymus (GO:0033089)2.39302838
163histone H3-K9 modification (GO:0061647)2.39002383
164histone H3 acetylation (GO:0043966)2.38682112
165regulation of interferon-beta production (GO:0032648)2.38114846
166tRNA modification (GO:0006400)2.35647535
167B cell receptor signaling pathway (GO:0050853)2.34416435
168poly(A)+ mRNA export from nucleus (GO:0016973)2.34201231
169natural killer cell differentiation (GO:0001779)2.34114913
170cellular extravasation (GO:0045123)2.33485088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.20607288
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96379416
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.42232017
4* MYC_22102868_ChIP-Seq_BL_Human3.17330012
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11341817
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.09903063
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75618011
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64644924
9CIITA_25753668_ChIP-Seq_RAJI_Human2.51718642
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47850392
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.34600877
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.29878889
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24474800
14AR_21909140_ChIP-Seq_LNCAP_Human2.09134010
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06790344
16E2F7_22180533_ChIP-Seq_HELA_Human10.4959919
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.99872998
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95450352
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89952128
20* XRN2_22483619_ChIP-Seq_HELA_Human1.89575993
21* VDR_24763502_ChIP-Seq_THP-1_Human1.88860250
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.85724067
23* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78236607
24* KDM5A_27292631_Chip-Seq_BREAST_Human1.77495681
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.76537755
26* VDR_23849224_ChIP-Seq_CD4+_Human1.74840186
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74577606
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74319893
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.74116849
30* ETS1_20019798_ChIP-Seq_JURKAT_Human1.73351542
31* VDR_21846776_ChIP-Seq_THP-1_Human1.72196902
32FOXP3_21729870_ChIP-Seq_TREG_Human1.72120162
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70260368
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.70159405
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62619754
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61585734
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61191934
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61146869
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55835076
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55548373
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54006390
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51069882
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48846639
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48582233
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46878999
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46813464
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.44382837
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42952832
49TCF7_22412390_ChIP-Seq_EML_Mouse1.42404987
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40170152
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38577461
52TTF2_22483619_ChIP-Seq_HELA_Human1.38196921
53UTX_26944678_Chip-Seq_JUKART_Human1.37737012
54MYB_26560356_Chip-Seq_TH1_Human1.36698019
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36055392
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35010899
57* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33767045
58* GABP_19822575_ChIP-Seq_HepG2_Human1.33762336
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33536144
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32748250
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29001046
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27895478
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27430725
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26732756
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26178460
66MAF_26560356_Chip-Seq_TH1_Human1.24312440
67P68_20966046_ChIP-Seq_HELA_Human1.23501631
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23158178
69* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22049326
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21212832
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20702041
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19007159
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18932331
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17538655
75MYB_26560356_Chip-Seq_TH2_Human1.17473729
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17455979
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.16525408
78BCL6_27268052_Chip-Seq_Bcells_Human1.15277484
79* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14452455
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14434375
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14298925
82KDM2B_26808549_Chip-Seq_DND41_Human1.13688986
83ELF1_20517297_ChIP-Seq_JURKAT_Human1.13073415
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12926906
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12839175
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12633536
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12576837
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.12458300
89* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12378203
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.12105295
91* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11973572
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11299399
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10837735
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10001427
95* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09505096
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09404067
97RUNX_20019798_ChIP-Seq_JUKART_Human1.09363242
98* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08660425
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08173138
100PHF8_20622854_ChIP-Seq_HELA_Human1.06858038
101ELK1_19687146_ChIP-ChIP_HELA_Human1.05588632
102LXR_22292898_ChIP-Seq_THP-1_Human1.04879159
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04429432
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04396963
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03997453
106SPI1_23547873_ChIP-Seq_NB4_Human1.03512613
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03335872
108* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01679102
109SCL_19346495_ChIP-Seq_HPC-7_Human1.00974834
110* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00382877
111DCP1A_22483619_ChIP-Seq_HELA_Human0.98548974
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97765185
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97750126
114TFEB_21752829_ChIP-Seq_HELA_Human0.94125551
115PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93776619
116ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93616568
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93258295
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92616800
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92251811
120YY1_21170310_ChIP-Seq_MESCs_Mouse0.91463440
121MAF_26560356_Chip-Seq_TH2_Human0.91181010
122* NCOR1_26117541_ChIP-Seq_K562_Human0.90653533
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89707374
124* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89146750
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88700052
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.87137088
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85116179
128CHD1_26751641_Chip-Seq_LNCaP_Human0.84907319
129* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84146007
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81927216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.78393890
2MP0003693_abnormal_embryo_hatching4.47624809
3MP0003111_abnormal_nucleus_morphology4.29023981
4MP0010094_abnormal_chromosome_stability4.20702662
5MP0003077_abnormal_cell_cycle3.77114813
6MP0002396_abnormal_hematopoietic_system3.33768117
7MP0004957_abnormal_blastocyst_morpholog3.33234810
8MP0008058_abnormal_DNA_repair3.06142135
9MP0008007_abnormal_cellular_replicative2.82994919
10MP0008260_abnormal_autophagy2.73723375
11MP0003436_decreased_susceptibility_to2.62268672
12MP0003646_muscle_fatigue2.61407598
13MP0003763_abnormal_thymus_physiology2.42862480
14MP0000350_abnormal_cell_proliferation2.37300700
15MP0001730_embryonic_growth_arrest2.34416410
16MP0004808_abnormal_hematopoietic_stem2.14177613
17MP0001835_abnormal_antigen_presentation2.11982523
18MP0003123_paternal_imprinting2.10893957
19MP0008877_abnormal_DNA_methylation2.06917337
20MP0005000_abnormal_immune_tolerance2.04630776
21MP0010352_gastrointestinal_tract_polyps2.00713899
22MP0001672_abnormal_embryogenesis/_devel1.95217262
23MP0005380_embryogenesis_phenotype1.95217262
24MP0001727_abnormal_embryo_implantation1.92042678
25MP0003121_genomic_imprinting1.85036770
26MP0010307_abnormal_tumor_latency1.83374173
27MP0003984_embryonic_growth_retardation1.83073046
28MP0000703_abnormal_thymus_morphology1.80868067
29MP0002088_abnormal_embryonic_growth/wei1.78020263
30MP0001697_abnormal_embryo_size1.74863233
31MP0002419_abnormal_innate_immunity1.69333331
32MP0002084_abnormal_developmental_patter1.69119736
33MP0002398_abnormal_bone_marrow1.66455266
34MP0005025_abnormal_response_to1.65346979
35MP0002085_abnormal_embryonic_tissue1.64594463
36MP0001790_abnormal_immune_system1.61648584
37MP0005387_immune_system_phenotype1.61648584
38MP0005310_abnormal_salivary_gland1.60857027
39MP0003787_abnormal_imprinting1.60721307
40MP0008932_abnormal_embryonic_tissue1.60604965
41MP0002086_abnormal_extraembryonic_tissu1.60299933
42MP0002080_prenatal_lethality1.58107702
43MP0004197_abnormal_fetal_growth/weight/1.55050154
44MP0006082_CNS_inflammation1.53898765
45MP0001853_heart_inflammation1.50831717
46MP0005076_abnormal_cell_differentiation1.50226199
47MP0003567_abnormal_fetal_cardiomyocyte1.49815600
48MP0003786_premature_aging1.46511797
49MP0001919_abnormal_reproductive_system1.44335396
50MP0005397_hematopoietic_system_phenotyp1.43867166
51MP0001545_abnormal_hematopoietic_system1.43867166
52MP0002722_abnormal_immune_system1.42446880
53MP0000569_abnormal_digit_pigmentation1.42052758
54MP0003172_abnormal_lysosome_physiology1.39529417
55MP0002019_abnormal_tumor_incidence1.39342094
56MP0000490_abnormal_crypts_of1.38388324
57MP0002148_abnormal_hypersensitivity_rea1.37610624
58MP0000689_abnormal_spleen_morphology1.37266277
59MP0004233_abnormal_muscle_weight1.37210338
60MP0006292_abnormal_olfactory_placode1.37078325
61MP0004947_skin_inflammation1.36001010
62MP0000313_abnormal_cell_death1.35864637
63MP0009278_abnormal_bone_marrow1.34242141
64MP0003303_peritoneal_inflammation1.32860914
65MP0002166_altered_tumor_susceptibility1.32808041
66MP0003890_abnormal_embryonic-extraembry1.28391914
67MP0009333_abnormal_splenocyte_physiolog1.26961557
68MP0001800_abnormal_humoral_immune1.25543194
69MP0002254_reproductive_system_inflammat1.23261988
70MP0005671_abnormal_response_to1.23043434
71MP0001293_anophthalmia1.20410036
72MP0002160_abnormal_reproductive_system1.19829824
73MP0009840_abnormal_foam_cell1.14045592
74MP0000716_abnormal_immune_system1.13821008
75MP0002009_preneoplasia1.10811985
76MP0002429_abnormal_blood_cell1.10478529
77MP0009785_altered_susceptibility_to1.07719136
78MP0009672_abnormal_birth_weight1.05433492
79MP0001845_abnormal_inflammatory_respons1.05020222
80MP0000537_abnormal_urethra_morphology1.04083005
81MP0009703_decreased_birth_body1.03893058
82MP0009764_decreased_sensitivity_to1.01206093
83MP0004264_abnormal_extraembryonic_tissu1.01147525
84MP0010155_abnormal_intestine_physiology1.00151185
85MP0003724_increased_susceptibility_to0.97738228
86MP0008469_abnormal_protein_level0.95275951
87MP0000428_abnormal_craniofacial_morphol0.93931688
88MP0002210_abnormal_sex_determination0.93446449
89MP0001873_stomach_inflammation0.92578008
90MP0002420_abnormal_adaptive_immunity0.92353185
91MP0002006_tumorigenesis0.91766814
92MP0000750_abnormal_muscle_regeneration0.91736346
93MP0001986_abnormal_taste_sensitivity0.90643583
94MP0001819_abnormal_immune_cell0.89583491
95MP0005451_abnormal_body_composition0.89329577
96MP0000733_abnormal_muscle_development0.88063323
97MP0000465_gastrointestinal_hemorrhage0.88006377
98MP0005389_reproductive_system_phenotype0.85522010
99MP0001348_abnormal_lacrimal_gland0.83924504
100MP0001145_abnormal_male_reproductive0.83843022
101MP0002653_abnormal_ependyma_morphology0.83730517
102MP0002092_abnormal_eye_morphology0.82783912
103MP0002452_abnormal_antigen_presenting0.82349151
104MP0002405_respiratory_system_inflammati0.81621407
105MP0005621_abnormal_cell_physiology0.81224520
106MP0000685_abnormal_immune_system0.80315208
107MP0003935_abnormal_craniofacial_develop0.79895259
108MP0002925_abnormal_cardiovascular_devel0.79465104
109MP0000470_abnormal_stomach_morphology0.78320045
110MP0001929_abnormal_gametogenesis0.78239827
111MP0005384_cellular_phenotype0.78009915
112MP0008770_decreased_survivor_rate0.76705765
113MP0002723_abnormal_immune_serum0.76488993
114MP0003221_abnormal_cardiomyocyte_apopto0.76126903
115MP0006035_abnormal_mitochondrial_morpho0.72784931
116MP0009931_abnormal_skin_appearance0.71705963
117MP0001915_intracranial_hemorrhage0.71614779
118MP0003119_abnormal_digestive_system0.71401788
119MP0000613_abnormal_salivary_gland0.70513501
120MP0008961_abnormal_basal_metabolism0.69644069
121MP0001849_ear_inflammation0.68504628
122MP0003866_abnormal_defecation0.68280864
123MP0005666_abnormal_adipose_tissue0.67151949
124MP0003656_abnormal_erythrocyte_physiolo0.66735352
125MP0001502_abnormal_circadian_rhythm0.66706252
126MP0000653_abnormal_sex_gland0.66679787
127MP0001851_eye_inflammation0.66266086
128MP0002132_abnormal_respiratory_system0.66264234
129MP0002075_abnormal_coat/hair_pigmentati0.66239665
130MP0003937_abnormal_limbs/digits/tail_de0.65704593
131MP0001216_abnormal_epidermal_layer0.65690997
132MP0003861_abnormal_nervous_system0.65563066
133MP0008995_early_reproductive_senescence0.63443299
134MP0000371_diluted_coat_color0.63217167
135MP0003828_pulmonary_edema0.63083391
136MP0005174_abnormal_tail_pigmentation0.63066080
137MP0000432_abnormal_head_morphology0.62701934
138MP0000266_abnormal_heart_morphology0.62285029
139MP0001784_abnormal_fluid_regulation0.61315783
140MP0000477_abnormal_intestine_morphology0.60587355
141MP0010030_abnormal_orbit_morphology0.60087460
142MP0001286_abnormal_eye_development0.59650888
143MP0004185_abnormal_adipocyte_glucose0.59168012

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.99978450
2Retrobulbar optic neuritis (HP:0100654)3.94626231
3Optic neuritis (HP:0100653)3.94626231
4Myositis (HP:0100614)3.78810422
5Ependymoma (HP:0002888)3.59019057
6Orchitis (HP:0100796)3.58046452
7Chromsome breakage (HP:0040012)3.47463159
8Volvulus (HP:0002580)3.45064965
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44344448
10Birth length less than 3rd percentile (HP:0003561)3.39210712
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.30379545
12Mediastinal lymphadenopathy (HP:0100721)3.29949022
13Fatigue (HP:0012378)3.26468104
14Prominent nose (HP:0000448)3.25053086
15Microvesicular hepatic steatosis (HP:0001414)3.24843572
16Deep palmar crease (HP:0006191)3.01509025
17Stomatitis (HP:0010280)3.00725967
18Elevated erythrocyte sedimentation rate (HP:0003565)3.00225408
19Medulloblastoma (HP:0002885)2.95185461
20Encephalitis (HP:0002383)2.88986003
21Progressive muscle weakness (HP:0003323)2.88271294
22Abnormality of chromosome stability (HP:0003220)2.82640136
23Recurrent fungal infections (HP:0002841)2.77882069
24Increased nuchal translucency (HP:0010880)2.73907453
25Patellar aplasia (HP:0006443)2.73280592
26T lymphocytopenia (HP:0005403)2.72615778
27Abnormality of the preputium (HP:0100587)2.72380361
28Myelodysplasia (HP:0002863)2.71112831
29Selective tooth agenesis (HP:0001592)2.70500646
30Basal cell carcinoma (HP:0002671)2.68974073
31Villous atrophy (HP:0011473)2.68740980
32Abnormality of small intestinal villus morphology (HP:0011472)2.68740980
33Meckel diverticulum (HP:0002245)2.68429852
34Long eyelashes (HP:0000527)2.67420564
35Agammaglobulinemia (HP:0004432)2.66205729
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60522609
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.58341638
38Arterial thrombosis (HP:0004420)2.58076781
39Proximal placement of thumb (HP:0009623)2.57087928
40Pustule (HP:0200039)2.56550775
41Abnormality of the ileum (HP:0001549)2.55700816
42Chronic mucocutaneous candidiasis (HP:0002728)2.55400424
43Recurrent cutaneous fungal infections (HP:0011370)2.55400424
44Anal stenosis (HP:0002025)2.54529024
45Aplasia/Hypoplasia of the patella (HP:0006498)2.52681402
46Keratoconjunctivitis sicca (HP:0001097)2.51139863
47Ectopic kidney (HP:0000086)2.49705975
48Abnormality of the labia minora (HP:0012880)2.49692451
49Facial hemangioma (HP:0000329)2.48407269
50Astrocytoma (HP:0009592)2.47857062
51Abnormality of the astrocytes (HP:0100707)2.47857062
52Colitis (HP:0002583)2.47543041
53Colon cancer (HP:0003003)2.45832971
54Abnormal number of incisors (HP:0011064)2.44377409
55Meningitis (HP:0001287)2.43847715
56Prostate neoplasm (HP:0100787)2.42780384
57Abnormality of T cell physiology (HP:0011840)2.42420506
58Hyperacusis (HP:0010780)2.42382283
59Deviation of the thumb (HP:0009603)2.42047851
60Granulocytopenia (HP:0001913)2.42044543
61Abnormality of T cell number (HP:0011839)2.41191565
62Abnormality of the columella (HP:0009929)2.40765127
63Partial agenesis of the corpus callosum (HP:0001338)2.40453207
64Impulsivity (HP:0100710)2.39090409
65Short 4th metacarpal (HP:0010044)2.38108467
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38108467
67Breast hypoplasia (HP:0003187)2.37120391
68Premature ovarian failure (HP:0008209)2.36514766
69IgM deficiency (HP:0002850)2.33192071
70Recurrent abscess formation (HP:0002722)2.32537338
71Asplenia (HP:0001746)2.31520618
72Neoplasm of the oral cavity (HP:0100649)2.29528400
73Keratoconjunctivitis (HP:0001096)2.27511208
74Abnormality of the carotid arteries (HP:0005344)2.27180834
75Lymphopenia (HP:0001888)2.27087460
76Rhabdomyosarcoma (HP:0002859)2.21353354
77Thoracic kyphosis (HP:0002942)2.20548047
78Sparse lateral eyebrow (HP:0005338)2.20329838
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.19565420
80Cafe-au-lait spot (HP:0000957)2.18224672
81Glioma (HP:0009733)2.17898368
82Gastrointestinal inflammation (HP:0004386)2.17704407
83Reticulocytopenia (HP:0001896)2.17666576
84Eczematoid dermatitis (HP:0000976)2.17486017
85Trigonocephaly (HP:0000243)2.16384425
86Aplasia/Hypoplasia of the spleen (HP:0010451)2.15791835
87Duodenal stenosis (HP:0100867)2.14359673
88Small intestinal stenosis (HP:0012848)2.14359673
89Long palpebral fissure (HP:0000637)2.14351017
90Diastasis recti (HP:0001540)2.12188706
91Panhypogammaglobulinemia (HP:0003139)2.11375022
92Viral hepatitis (HP:0006562)2.11238565
93Inflammation of the large intestine (HP:0002037)2.10671994
94Aplasia/Hypoplasia of the thymus (HP:0010515)2.10396057
95Abnormality of lateral ventricle (HP:0030047)2.09319970
96High pitched voice (HP:0001620)2.08188937
97Vasculitis (HP:0002633)2.07595212
98Acute lymphatic leukemia (HP:0006721)2.07418255
99Obstructive sleep apnea (HP:0002870)2.06959725
100Increased IgE level (HP:0003212)2.06690078
101Acute myeloid leukemia (HP:0004808)2.05664510
102Hypochromic anemia (HP:0001931)2.04903419
103Neoplasm of striated muscle (HP:0009728)2.03838868
104Pelvic girdle muscle weakness (HP:0003749)2.02855791
105Clumsiness (HP:0002312)2.01959144
106Duplicated collecting system (HP:0000081)2.01828371
107Lymphoma (HP:0002665)2.00498083
108Agnosia (HP:0010524)2.00497211
109Optic nerve coloboma (HP:0000588)2.00377305
110Severe visual impairment (HP:0001141)1.99220553
111Skin tags (HP:0010609)1.99197852
112Truncal obesity (HP:0001956)1.99091009
113Eosinophilia (HP:0001880)1.99036013
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.97764389
115Abnormality of T cells (HP:0002843)1.97414757
116Seborrheic dermatitis (HP:0001051)1.97120562
117Abnormality of DNA repair (HP:0003254)1.97017869
118Cerebellar dysplasia (HP:0007033)1.96577089
119Broad palm (HP:0001169)1.96361309
120Chest pain (HP:0100749)1.96314859
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96085305
122Pulmonary infiltrates (HP:0002113)1.95266088
123Heterotopia (HP:0002282)1.94232804
124Hemoptysis (HP:0002105)1.94036483
125Hypertensive crisis (HP:0100735)1.93722390
126Poikiloderma (HP:0001029)1.92011592
127Cutis marmorata (HP:0000965)1.91400287
128Sloping forehead (HP:0000340)1.90817079
129Microtia (HP:0008551)1.89800587
130Urethral obstruction (HP:0000796)1.88798558
131IgG deficiency (HP:0004315)1.88442454
132Gastrointestinal infarctions (HP:0005244)1.88271679
133Amaurosis fugax (HP:0100576)1.87694371
134Sandal gap (HP:0001852)1.86910629
135Anorexia (HP:0002039)1.85033671
136Biliary tract neoplasm (HP:0100574)1.84713318
137Abnormality of the renal collecting system (HP:0004742)1.84622996
138Tracheoesophageal fistula (HP:0002575)1.84555158
139Atresia of the external auditory canal (HP:0000413)1.84111099
140Leukocytosis (HP:0001974)1.83332724
141Recurrent viral infections (HP:0004429)1.82100262
142Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82080387
143Clubbing of toes (HP:0100760)1.81557287
144Abnormality of cells of the erythroid lineage (HP:0012130)1.81047211
145Dislocated radial head (HP:0003083)1.81018486
146Neoplasm of the pancreas (HP:0002894)1.80869816
147Vertebral arch anomaly (HP:0008438)1.80554278
148Absent radius (HP:0003974)1.80365752
149Bone marrow hypocellularity (HP:0005528)1.80336663
150Preauricular skin tag (HP:0000384)1.80186992
151Abnormality of B cell number (HP:0010975)1.79758485
152Obsessive-compulsive behavior (HP:0000722)1.79389540
153Overlapping toe (HP:0001845)1.78404824
154Autoimmune hemolytic anemia (HP:0001890)1.78074824
155Abnormal number of erythroid precursors (HP:0012131)1.77838988
156Recurrent bacterial skin infections (HP:0005406)1.76652728
157Abnormality of the duodenum (HP:0002246)1.75977895
158Gastrointestinal carcinoma (HP:0002672)1.72957410
159Malignant gastrointestinal tract tumors (HP:0006749)1.72957410
160Squamous cell carcinoma (HP:0002860)1.72384197
161Low anterior hairline (HP:0000294)1.71748414
162Entropion (HP:0000621)1.71073498
163Absent forearm bone (HP:0003953)1.70850690
164Aplasia involving forearm bones (HP:0009822)1.70850690
165Overriding aorta (HP:0002623)1.70389577
166Absent thumb (HP:0009777)1.69938548
167Rib fusion (HP:0000902)1.67905362
168Renal duplication (HP:0000075)1.67637412
169Premature graying of hair (HP:0002216)1.67226734
170Oligodactyly (HP:0012165)1.65874307
171Thrombocytosis (HP:0001894)1.65793432
172Combined immunodeficiency (HP:0005387)1.65508935
173Supernumerary ribs (HP:0005815)1.65366327
174Abnormality of the musculature of the pelvis (HP:0001469)1.63291772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.18339656
2CDK123.72597982
3NEK23.36284313
4IRAK43.27362527
5EEF2K3.12463951
6WEE13.05154346
7SMG12.85084415
8MAP4K12.50301442
9TAOK32.38908749
10BRD42.35506976
11BUB12.32352553
12STK102.10003293
13TSSK62.08464796
14PRPF4B2.07869957
15TTK2.06217488
16SRPK12.04391826
17CDK41.95714783
18ATR1.94734618
19TAF11.92326449
20MAP3K101.80952501
21CDK71.79847427
22LATS11.79288794
23DYRK31.77659583
24ZAK1.73174016
25ERN11.72923205
26TNK21.70263136
27RIPK41.67363077
28RPS6KB21.63855747
29MKNK21.58178698
30CHEK11.54986184
31SIK21.54897516
32MAP3K141.50638751
33PLK11.49545504
34PKN21.49504696
35ACVR1B1.47600951
36AURKB1.46493244
37CHEK21.45020621
38MKNK11.44477533
39IKBKB1.43241524
40RPS6KA41.39762143
41MAP3K131.39493897
42TNIK1.38500325
43BRSK21.33585601
44IRAK31.32578812
45NME21.32085699
46ALK1.30797735
47PRKD21.27690041
48STK31.25290546
49PNCK1.22725104
50MAPK111.21701135
51CDK61.21556594
52IRAK21.19020459
53IKBKE1.18993880
54CDK21.17747211
55ITK1.16852596
56ATM1.15873505
57ICK1.12641373
58MTOR1.11288095
59PASK1.10696425
60BLK1.09379659
61MARK31.07598101
62TBK11.06841946
63PLK41.06749100
64IRAK11.06653704
65FES1.06603115
66MAP2K21.05474141
67STK41.00085571
68PIM10.98362453
69MAP3K80.96596561
70PLK30.96544084
71MELK0.95665823
72PRKCH0.95664384
73GRK60.93214078
74HIPK20.92765719
75CAMK1D0.91652383
76BRAF0.90869118
77BTK0.89756434
78NEK10.88650006
79CHUK0.87444403
80CAMK1G0.87393100
81FGFR40.87062914
82CDK10.85386592
83TGFBR10.85092424
84JAK30.82531241
85PIK3CG0.81840387
86TXK0.80875026
87LATS20.79769246
88PAK40.79052370
89BRSK10.77962547
90ZAP700.76580232
91MAP2K30.75784728
92MAP2K60.75332269
93SIK30.74716993
94EIF2AK10.73984571
95CDK90.73822921
96MAP3K30.72912590
97TRIB30.71438600
98SCYL20.70613906
99SIK10.70390583
100STK110.69954043
101MARK20.66702631
102EIF2AK30.66592626
103RPS6KC10.66234759
104RPS6KL10.66234759
105MAP3K60.61817612
106AKT30.61192321
107SYK0.60946788
108MAPK140.60743977
109CSNK1E0.59666373
110PRKCQ0.57553669
111LRRK20.56301766
112MAP3K90.56229318
113PRKDC0.56163670
114CSF1R0.56109774
115VRK10.56073895
116GRK10.55710315
117KIT0.55694569
118CLK10.54926932
119CSK0.54678286
120STK380.54600001
121CSNK1D0.54191016
122RPS6KA60.53621637
123MAP3K10.53230785
124FGFR10.53115345
125MAPK100.52796726
126TTN0.52363774
127TEC0.51341198
128NLK0.50337742
129PDK10.49694224
130AKT20.49654753
131LCK0.48457038
132NUAK10.48241003
133GSK3B0.47891774
134* CSNK2A20.47148546
135RPS6KA10.47106612
136LYN0.46744045
137SGK30.46526553
138TYK20.46454060
139MAPK70.46312476
140TLK10.45649795
141PAK20.45022101
142PDPK10.44925497
143TGFBR20.44412281
144FLT30.44023193
145MAPKAPK30.41870242
146FGFR30.41049234
147HCK0.40918056
148AURKA0.40014426
149MAPK10.39840768
150RAF10.36938095
151PRKCI0.35465878

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.52042783
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35618792
3Spliceosome_Homo sapiens_hsa030403.27003290
4Mismatch repair_Homo sapiens_hsa034303.17368282
5RNA transport_Homo sapiens_hsa030133.00562102
6Cell cycle_Homo sapiens_hsa041102.70069125
7Base excision repair_Homo sapiens_hsa034102.37038890
8mRNA surveillance pathway_Homo sapiens_hsa030152.35144260
9Fanconi anemia pathway_Homo sapiens_hsa034602.31444508
10Primary immunodeficiency_Homo sapiens_hsa053402.26920499
11Homologous recombination_Homo sapiens_hsa034402.17283890
12RNA polymerase_Homo sapiens_hsa030202.05867968
13Non-homologous end-joining_Homo sapiens_hsa034501.93501366
14Nucleotide excision repair_Homo sapiens_hsa034201.90296241
15RNA degradation_Homo sapiens_hsa030181.87020686
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80768021
17One carbon pool by folate_Homo sapiens_hsa006701.76374002
18Basal transcription factors_Homo sapiens_hsa030221.56620480
19p53 signaling pathway_Homo sapiens_hsa041151.55287198
20Leishmaniasis_Homo sapiens_hsa051401.54304557
21Herpes simplex infection_Homo sapiens_hsa051681.43124962
22Antigen processing and presentation_Homo sapiens_hsa046121.39615105
23Regulation of autophagy_Homo sapiens_hsa041401.36390940
24Lysine degradation_Homo sapiens_hsa003101.35032761
25Other glycan degradation_Homo sapiens_hsa005111.34418643
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33886046
27Ribosome_Homo sapiens_hsa030101.30207294
28Pyrimidine metabolism_Homo sapiens_hsa002401.28539213
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26462015
30Allograft rejection_Homo sapiens_hsa053301.24977978
31TNF signaling pathway_Homo sapiens_hsa046681.24735590
32T cell receptor signaling pathway_Homo sapiens_hsa046601.24488234
33Epstein-Barr virus infection_Homo sapiens_hsa051691.24350079
34B cell receptor signaling pathway_Homo sapiens_hsa046621.22762587
35MicroRNAs in cancer_Homo sapiens_hsa052061.17646813
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17132595
37Autoimmune thyroid disease_Homo sapiens_hsa053201.15203738
38Chronic myeloid leukemia_Homo sapiens_hsa052201.15034870
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14805245
40Colorectal cancer_Homo sapiens_hsa052101.13361604
41HTLV-I infection_Homo sapiens_hsa051661.13259405
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12925187
43Viral carcinogenesis_Homo sapiens_hsa052031.12845204
44Tuberculosis_Homo sapiens_hsa051521.11614036
45Oocyte meiosis_Homo sapiens_hsa041141.10965946
46Graft-versus-host disease_Homo sapiens_hsa053321.09681979
47Small cell lung cancer_Homo sapiens_hsa052221.04984535
48mTOR signaling pathway_Homo sapiens_hsa041501.04078992
49Hepatitis C_Homo sapiens_hsa051601.03904238
50Thyroid cancer_Homo sapiens_hsa052160.99919436
51Notch signaling pathway_Homo sapiens_hsa043300.95458247
52Measles_Homo sapiens_hsa051620.93725100
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.93582794
54Acute myeloid leukemia_Homo sapiens_hsa052210.91551834
55Non-small cell lung cancer_Homo sapiens_hsa052230.91030439
56Asthma_Homo sapiens_hsa053100.90546121
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87063930
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85899907
59Hepatitis B_Homo sapiens_hsa051610.84378302
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81988969
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79124224
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78925880
63Hematopoietic cell lineage_Homo sapiens_hsa046400.76484821
64Bladder cancer_Homo sapiens_hsa052190.76217571
65Pancreatic cancer_Homo sapiens_hsa052120.74344036
66Systemic lupus erythematosus_Homo sapiens_hsa053220.71555584
67Vitamin B6 metabolism_Homo sapiens_hsa007500.71410188
68Prostate cancer_Homo sapiens_hsa052150.71182162
69Endometrial cancer_Homo sapiens_hsa052130.70026019
70Insulin resistance_Homo sapiens_hsa049310.69568797
71Purine metabolism_Homo sapiens_hsa002300.67805736
72FoxO signaling pathway_Homo sapiens_hsa040680.67076306
73Type I diabetes mellitus_Homo sapiens_hsa049400.65603152
74Viral myocarditis_Homo sapiens_hsa054160.65352763
75Basal cell carcinoma_Homo sapiens_hsa052170.65101909
76Legionellosis_Homo sapiens_hsa051340.64056440
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.63744622
78Adherens junction_Homo sapiens_hsa045200.63559240
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60930867
80Dorso-ventral axis formation_Homo sapiens_hsa043200.59770527
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.59670656
82Inositol phosphate metabolism_Homo sapiens_hsa005620.59441896
83Pathways in cancer_Homo sapiens_hsa052000.57946271
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.57152336
85Influenza A_Homo sapiens_hsa051640.56109466
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.54828069
87Hippo signaling pathway_Homo sapiens_hsa043900.54031902
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53640590
89Apoptosis_Homo sapiens_hsa042100.52663134
90Wnt signaling pathway_Homo sapiens_hsa043100.52541905
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52429728
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.51731654
93Osteoclast differentiation_Homo sapiens_hsa043800.50852028
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49484089
95VEGF signaling pathway_Homo sapiens_hsa043700.47509727
96Choline metabolism in cancer_Homo sapiens_hsa052310.46111149
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45553913
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45258941
99Staphylococcus aureus infection_Homo sapiens_hsa051500.45218580
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45141754
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45024014
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.43077632
103Pentose phosphate pathway_Homo sapiens_hsa000300.42987586
104Renal cell carcinoma_Homo sapiens_hsa052110.42088136
105Proteoglycans in cancer_Homo sapiens_hsa052050.42057655
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40985360
107HIF-1 signaling pathway_Homo sapiens_hsa040660.40866726
108Platelet activation_Homo sapiens_hsa046110.40647373
109MAPK signaling pathway_Homo sapiens_hsa040100.40490605
110TGF-beta signaling pathway_Homo sapiens_hsa043500.39013438
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38700382
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37814890
113Prolactin signaling pathway_Homo sapiens_hsa049170.36412441
114Shigellosis_Homo sapiens_hsa051310.36096625
115Chemokine signaling pathway_Homo sapiens_hsa040620.33801462
116Toxoplasmosis_Homo sapiens_hsa051450.33279772
117Selenocompound metabolism_Homo sapiens_hsa004500.33009912
118AMPK signaling pathway_Homo sapiens_hsa041520.32575327
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31824047
120Glioma_Homo sapiens_hsa052140.30961069
121Circadian rhythm_Homo sapiens_hsa047100.30374263

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