AKAP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.90728073
2epithelial cilium movement (GO:0003351)3.91547339
3behavioral response to nicotine (GO:0035095)3.83705402
4neural tube formation (GO:0001841)3.73714448
5cilium movement (GO:0003341)3.68477250
6retrograde transport, vesicle recycling within Golgi (GO:0000301)3.60393191
7histone H3-K4 trimethylation (GO:0080182)3.55863567
8protein targeting to Golgi (GO:0000042)3.51807154
9establishment of protein localization to Golgi (GO:0072600)3.48518853
10dendrite morphogenesis (GO:0048813)3.47688725
11dendritic spine morphogenesis (GO:0060997)3.37668253
12cilium or flagellum-dependent cell motility (GO:0001539)3.31402406
13central nervous system projection neuron axonogenesis (GO:0021952)3.30935776
14axoneme assembly (GO:0035082)3.29457271
15neuron cell-cell adhesion (GO:0007158)3.26888205
16intraciliary transport (GO:0042073)3.24333302
17axonal fasciculation (GO:0007413)3.22725935
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.20406600
19centriole replication (GO:0007099)3.12944066
20neuron recognition (GO:0008038)3.09653806
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09427883
22presynaptic membrane assembly (GO:0097105)3.09399002
23vocalization behavior (GO:0071625)3.08511364
24positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.08243243
25cerebellar Purkinje cell differentiation (GO:0021702)3.04492272
26layer formation in cerebral cortex (GO:0021819)3.04197263
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03415600
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.03415600
29regulation of translation, ncRNA-mediated (GO:0045974)3.03415600
30behavioral response to ethanol (GO:0048149)2.99220365
31protein localization to cilium (GO:0061512)2.98598217
32nonmotile primary cilium assembly (GO:0035058)2.95295820
33gamma-aminobutyric acid transport (GO:0015812)2.94716993
34cytoplasmic mRNA processing body assembly (GO:0033962)2.92679551
35cilium organization (GO:0044782)2.92116136
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.90958365
37regulation of cilium movement (GO:0003352)2.90259733
38limb bud formation (GO:0060174)2.87209056
39cilium assembly (GO:0042384)2.86441361
40glial cell proliferation (GO:0014009)2.84411861
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81089877
42cerebral cortex radially oriented cell migration (GO:0021799)2.80394484
43presynaptic membrane organization (GO:0097090)2.79224767
44neuronal action potential (GO:0019228)2.79194599
45axonemal dynein complex assembly (GO:0070286)2.77926715
46embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77848937
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77804372
48regulation of glutamate receptor signaling pathway (GO:1900449)2.75990280
49neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.75977365
50postsynaptic membrane organization (GO:0001941)2.75767196
51hindbrain development (GO:0030902)2.73487868
52pyrimidine nucleobase catabolic process (GO:0006208)2.73445131
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.70731334
54neuronal action potential propagation (GO:0019227)2.70594245
55inner ear receptor cell development (GO:0060119)2.68824037
56cilium morphogenesis (GO:0060271)2.68765097
57limb development (GO:0060173)2.68270540
58appendage development (GO:0048736)2.68270540
59retinal ganglion cell axon guidance (GO:0031290)2.67560820
60spinal cord motor neuron differentiation (GO:0021522)2.66948223
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66034652
62detection of light stimulus involved in sensory perception (GO:0050962)2.66015709
63detection of light stimulus involved in visual perception (GO:0050908)2.66015709
64stress granule assembly (GO:0034063)2.64744514
65central nervous system neuron axonogenesis (GO:0021955)2.64522798
66somite development (GO:0061053)2.63291280
67regulation of action potential (GO:0098900)2.62895752
68prepulse inhibition (GO:0060134)2.61246627
69microtubule anchoring (GO:0034453)2.58180033
70L-fucose metabolic process (GO:0042354)2.57456196
71L-fucose catabolic process (GO:0042355)2.57456196
72fucose catabolic process (GO:0019317)2.57456196
73membrane depolarization during action potential (GO:0086010)2.55733562
74glutamate receptor signaling pathway (GO:0007215)2.53679429
75cornea development in camera-type eye (GO:0061303)2.52865301
76microtubule bundle formation (GO:0001578)2.52408729
77locomotory exploration behavior (GO:0035641)2.52330074
78establishment of nucleus localization (GO:0040023)2.51494550
79response to pheromone (GO:0019236)2.51411231
80photoreceptor cell maintenance (GO:0045494)2.51048034
81positive regulation of sodium ion transmembrane transport (GO:1902307)2.49636043
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48084710
83nucleus localization (GO:0051647)2.48071754
84retinal cone cell development (GO:0046549)2.45766277
85neuronal ion channel clustering (GO:0045161)2.44687870
86Golgi to endosome transport (GO:0006895)2.44642623
87histone H3-K4 methylation (GO:0051568)2.43287315
88cell migration in hindbrain (GO:0021535)2.42654557
89photoreceptor cell development (GO:0042461)2.42248510
90insulin-like growth factor receptor signaling pathway (GO:0048009)2.41407482
91regulation of telomere maintenance (GO:0032204)2.41344294
92kidney morphogenesis (GO:0060993)2.41106439
93cellular component assembly involved in morphogenesis (GO:0010927)2.40992529
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39643704
95protein polyglutamylation (GO:0018095)2.38846710
96homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.38575238
97action potential (GO:0001508)2.38344385
98striatum development (GO:0021756)2.37875730
99regulation of dendritic spine morphogenesis (GO:0061001)2.37717144
100brain morphogenesis (GO:0048854)2.37392821
101nucleobase catabolic process (GO:0046113)2.37276827
102positive regulation of dendritic spine morphogenesis (GO:0061003)2.37169533
103protein localization to synapse (GO:0035418)2.37001888
104cellular ketone body metabolic process (GO:0046950)2.36975932
105peptidyl-lysine trimethylation (GO:0018023)2.36687932
106regulation of pigment cell differentiation (GO:0050932)2.36199714
107transmission of nerve impulse (GO:0019226)2.36188603
108interkinetic nuclear migration (GO:0022027)2.34962530
109auditory behavior (GO:0031223)2.34905282
110synapse assembly (GO:0007416)2.34827602
111positive regulation of cardiac muscle cell differentiation (GO:2000727)2.33355696
112nerve growth factor signaling pathway (GO:0038180)2.33033700
113regulation of sarcomere organization (GO:0060297)2.33032506
114auditory receptor cell differentiation (GO:0042491)2.32310121
115neurotransmitter-gated ion channel clustering (GO:0072578)2.31331060
116eye photoreceptor cell development (GO:0042462)2.31012081
117positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30844294
118histone H3-K36 demethylation (GO:0070544)2.30818617
119cAMP catabolic process (GO:0006198)2.30650852
120startle response (GO:0001964)2.29790112
121dentate gyrus development (GO:0021542)2.29159814
122cyclic nucleotide catabolic process (GO:0009214)2.29033847
123cerebellum development (GO:0021549)2.28563165
124olfactory bulb development (GO:0021772)2.28108459
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27442638
126dendritic spine organization (GO:0097061)2.26404747
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.26352250
128protein K11-linked deubiquitination (GO:0035871)2.26229393
129innervation (GO:0060384)2.25182124
130regulation of respiratory system process (GO:0044065)2.23925880
131mitotic sister chromatid cohesion (GO:0007064)2.22749342
132sympathetic nervous system development (GO:0048485)2.22734369
133adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.21788737
134synaptic transmission, glutamatergic (GO:0035249)2.21771385
135multicellular organismal signaling (GO:0035637)2.20897156
136axon extension (GO:0048675)2.20171938
137neuronal stem cell maintenance (GO:0097150)2.19857907
138negative regulation of dendrite development (GO:2000171)2.19529178
139dendrite development (GO:0016358)2.19231360
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.19164286
141regulation of axon extension involved in axon guidance (GO:0048841)2.18400776
142anatomical structure arrangement (GO:0048532)2.17121949
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.16215481
144membrane hyperpolarization (GO:0060081)2.15794469
145retina layer formation (GO:0010842)2.15744036
146cell differentiation in hindbrain (GO:0021533)2.15158772
147neuron-neuron synaptic transmission (GO:0007270)2.14305907
148cardiac ventricle formation (GO:0003211)2.14071114
149regulation of postsynaptic membrane potential (GO:0060078)2.13643741
150exploration behavior (GO:0035640)2.13624308
151cardiac conduction (GO:0061337)2.13351714
152regulation of neuron migration (GO:2001222)2.12892344
153regulation of axon guidance (GO:1902667)2.12461412
154regulation of synapse assembly (GO:0051963)2.11551821
155mechanosensory behavior (GO:0007638)2.11246653
156regulation of excitatory postsynaptic membrane potential (GO:0060079)2.11179394
157synapse organization (GO:0050808)2.11021061
158protein localization to Golgi apparatus (GO:0034067)2.08900135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.41262189
2GBX2_23144817_ChIP-Seq_PC3_Human3.33612278
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52735771
4VDR_22108803_ChIP-Seq_LS180_Human2.46290352
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33824081
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14185910
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04801049
8JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99261119
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96987415
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96129326
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94158259
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91534638
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91433437
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91147025
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.86664217
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83619435
17DROSHA_22980978_ChIP-Seq_HELA_Human1.82981969
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79873719
19SMAD4_21799915_ChIP-Seq_A2780_Human1.78149836
20SALL1_21062744_ChIP-ChIP_HESCs_Human1.77358255
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.77318752
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75803204
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75038662
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74753218
25AR_21572438_ChIP-Seq_LNCaP_Human1.73884345
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72903387
27TAF15_26573619_Chip-Seq_HEK293_Human1.70117359
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69986486
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69986486
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69707714
31P300_19829295_ChIP-Seq_ESCs_Human1.68835286
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67296668
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.65336470
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64409512
35* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64404193
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62447323
37AHR_22903824_ChIP-Seq_MCF-7_Human1.60196866
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.59689317
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.58150261
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.56423870
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.53945114
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51907004
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51907004
44* STAT3_23295773_ChIP-Seq_U87_Human1.50070216
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49974486
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48925147
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.48879739
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48437282
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48064168
50CBP_20019798_ChIP-Seq_JUKART_Human1.47729302
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47729302
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47378416
53IGF1R_20145208_ChIP-Seq_DFB_Human1.46486639
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45142963
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44909255
56FUS_26573619_Chip-Seq_HEK293_Human1.44767072
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44122445
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.42525923
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41549084
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37791435
61TP53_16413492_ChIP-PET_HCT116_Human1.36152060
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.36144277
63REST_21632747_ChIP-Seq_MESCs_Mouse1.36006597
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.35204791
65* TCF4_23295773_ChIP-Seq_U87_Human1.35013741
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.34809750
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34660452
68* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33531203
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29785591
70TCF4_22108803_ChIP-Seq_LS180_Human1.27564688
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27551997
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26778451
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26769669
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26467415
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26301736
76AR_25329375_ChIP-Seq_VCAP_Human1.25349934
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22921838
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.22628436
79ZNF274_21170338_ChIP-Seq_K562_Hela1.22131747
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21646671
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21452076
82BCAT_22108803_ChIP-Seq_LS180_Human1.20893979
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20292064
84AR_19668381_ChIP-Seq_PC3_Human1.19264021
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.18825528
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18219178
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.17957827
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17778264
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17551182
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.16817307
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16456732
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14927083
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.14712079
94TP53_18474530_ChIP-ChIP_U2OS_Human1.14371390
95* ER_23166858_ChIP-Seq_MCF-7_Human1.13395624
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13222834
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13067851
98P53_22387025_ChIP-Seq_ESCs_Mouse1.12755893
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.12076101
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12063201
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12042908
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.11662992
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.10902084
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10541836
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.10531355
106* RNF2_27304074_Chip-Seq_NSC_Mouse1.10367058
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09926929
108EWS_26573619_Chip-Seq_HEK293_Human1.09486262
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08954516
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08740569
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07651712
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07570128
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.07022161
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06929622
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.06547883
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05607820
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05135695
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04964738
119JUN_21703547_ChIP-Seq_K562_Human1.04564591
120KDM2B_26808549_Chip-Seq_REH_Human1.04227179
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.03849055
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03466971
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03165364
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02943861
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.01742925
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01191192
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.97976814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.39977129
2MP0003787_abnormal_imprinting3.00615833
3MP0004270_analgesia2.74020853
4MP0009780_abnormal_chondrocyte_physiolo2.67746295
5MP0000778_abnormal_nervous_system2.53416346
6MP0003880_abnormal_central_pattern2.50637192
7MP0004859_abnormal_synaptic_plasticity2.40210150
8MP0008877_abnormal_DNA_methylation2.35421802
9MP0005645_abnormal_hypothalamus_physiol2.30666060
10MP0001188_hyperpigmentation2.21810390
11MP0005423_abnormal_somatic_nervous2.18815437
12MP0001486_abnormal_startle_reflex2.17472960
13MP0000566_synostosis2.10714290
14MP0003635_abnormal_synaptic_transmissio2.07595882
15MP0004043_abnormal_pH_regulation1.92842950
16MP0002735_abnormal_chemical_nociception1.88291995
17MP0002063_abnormal_learning/memory/cond1.84369025
18MP0005409_darkened_coat_color1.82643214
19MP0005248_abnormal_Harderian_gland1.76015781
20MP0002184_abnormal_innervation1.71568421
21MP0005646_abnormal_pituitary_gland1.70742477
22MP0002822_catalepsy1.67386381
23MP0005187_abnormal_penis_morphology1.66285247
24MP0002557_abnormal_social/conspecific_i1.64751504
25MP0009745_abnormal_behavioral_response1.62247654
26MP0002837_dystrophic_cardiac_calcinosis1.59848200
27MP0002572_abnormal_emotion/affect_behav1.57662130
28MP0002734_abnormal_mechanical_nocicepti1.56043627
29MP0003195_calcinosis1.55925027
30MP0004142_abnormal_muscle_tone1.54894820
31MP0002736_abnormal_nociception_after1.53642242
32MP0001984_abnormal_olfaction1.47416194
33MP0003890_abnormal_embryonic-extraembry1.46746449
34MP0005499_abnormal_olfactory_system1.46448380
35MP0005394_taste/olfaction_phenotype1.46448380
36MP0006072_abnormal_retinal_apoptosis1.45663977
37MP0000631_abnormal_neuroendocrine_gland1.45606903
38MP0004885_abnormal_endolymph1.45419609
39MP0000462_abnormal_digestive_system1.44737962
40MP0001299_abnormal_eye_distance/1.44281582
41MP0010386_abnormal_urinary_bladder1.42285473
42MP0006292_abnormal_olfactory_placode1.40268291
43MP0004133_heterotaxia1.39003455
44MP0002909_abnormal_adrenal_gland1.38995185
45MP0003121_genomic_imprinting1.38401933
46MP0003122_maternal_imprinting1.38387233
47MP0005551_abnormal_eye_electrophysiolog1.38381686
48MP0005386_behavior/neurological_phenoty1.37280282
49MP0004924_abnormal_behavior1.37280282
50MP0003385_abnormal_body_wall1.36626879
51MP0008057_abnormal_DNA_replication1.36301231
52MP0009046_muscle_twitch1.34194801
53MP0006276_abnormal_autonomic_nervous1.33497664
54MP0008789_abnormal_olfactory_epithelium1.29621350
55MP0001502_abnormal_circadian_rhythm1.26434821
56MP0004145_abnormal_muscle_electrophysio1.25031901
57MP0003183_abnormal_peptide_metabolism1.24597750
58MP0003646_muscle_fatigue1.23333664
59MP0002067_abnormal_sensory_capabilities1.21549774
60MP0004742_abnormal_vestibular_system1.21123328
61MP0008995_early_reproductive_senescence1.20448858
62MP0004147_increased_porphyrin_level1.20388775
63MP0003045_fibrosis1.18788179
64MP0010678_abnormal_skin_adnexa1.14773631
65MP0002938_white_spotting1.14741656
66MP0001529_abnormal_vocalization1.14507097
67MP0002882_abnormal_neuron_morphology1.14179835
68MP0000537_abnormal_urethra_morphology1.13687060
69MP0002876_abnormal_thyroid_physiology1.13683926
70MP0001970_abnormal_pain_threshold1.13208867
71MP0003283_abnormal_digestive_organ1.13021550
72MP0002272_abnormal_nervous_system1.12965011
73MP0000955_abnormal_spinal_cord1.12871427
74MP0001440_abnormal_grooming_behavior1.09137662
75MP0005379_endocrine/exocrine_gland_phen1.04626738
76MP0000383_abnormal_hair_follicle1.03853277
77MP0005171_absent_coat_pigmentation1.03495303
78MP0008872_abnormal_physiological_respon1.03017213
79MP0003935_abnormal_craniofacial_develop1.02541893
80MP0004085_abnormal_heartbeat1.01790002
81MP0002064_seizures1.01122543
82MP0002152_abnormal_brain_morphology1.00900183
83MP0008875_abnormal_xenobiotic_pharmacok1.00784708
84MP0010234_abnormal_vibrissa_follicle0.99008899
85MP0003861_abnormal_nervous_system0.98980937
86MP0002009_preneoplasia0.98469894
87MP0001177_atelectasis0.97510584
88MP0003941_abnormal_skin_development0.96279761
89MP0004811_abnormal_neuron_physiology0.95162433
90MP0000579_abnormal_nail_morphology0.94426746
91MP0000516_abnormal_urinary_system0.93744877
92MP0005367_renal/urinary_system_phenotyp0.93744877
93MP0005253_abnormal_eye_physiology0.93515234
94MP0002160_abnormal_reproductive_system0.92755235
95MP0002751_abnormal_autonomic_nervous0.92622453
96MP0000538_abnormal_urinary_bladder0.92073408
97MP0003937_abnormal_limbs/digits/tail_de0.91374185
98MP0005195_abnormal_posterior_eye0.89861598
99MP0002234_abnormal_pharynx_morphology0.89786386
100MP0002638_abnormal_pupillary_reflex0.89015473
101MP0002102_abnormal_ear_morphology0.88263925
102MP0004134_abnormal_chest_morphology0.87502150
103MP0001501_abnormal_sleep_pattern0.87140264
104MP0002733_abnormal_thermal_nociception0.86785818
105MP0002229_neurodegeneration0.86753502
106MP0003755_abnormal_palate_morphology0.85728108
107MP0001986_abnormal_taste_sensitivity0.84630314
108MP0009703_decreased_birth_body0.84292144
109MP0000427_abnormal_hair_cycle0.84185903
110MP0002752_abnormal_somatic_nervous0.83850794
111MP0002254_reproductive_system_inflammat0.83690710
112MP0003633_abnormal_nervous_system0.83485619
113MP0008569_lethality_at_weaning0.83448836
114MP0002116_abnormal_craniofacial_bone0.83447188
115MP0002233_abnormal_nose_morphology0.83261332
116MP0005174_abnormal_tail_pigmentation0.83087860
117MP0003137_abnormal_impulse_conducting0.82766440
118MP0002928_abnormal_bile_duct0.82222115
119MP0001968_abnormal_touch/_nociception0.81182053
120MP0001346_abnormal_lacrimal_gland0.79376562
121MP0003868_abnormal_feces_composition0.77350556
122MP0000015_abnormal_ear_pigmentation0.76732098
123MP0001485_abnormal_pinna_reflex0.76414613
124MP0001944_abnormal_pancreas_morphology0.75923751
125MP0002177_abnormal_outer_ear0.75891358
126MP0004215_abnormal_myocardial_fiber0.75704373
127MP0000026_abnormal_inner_ear0.75508299
128MP0002066_abnormal_motor_capabilities/c0.74755016
129MP0002653_abnormal_ependyma_morphology0.72620523

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)3.87725496
2Pancreatic cysts (HP:0001737)3.85842812
3Pancreatic fibrosis (HP:0100732)3.84234921
4Molar tooth sign on MRI (HP:0002419)3.76970696
5Abnormality of midbrain morphology (HP:0002418)3.76970696
6Abnormality of the renal medulla (HP:0100957)3.56502790
7Abnormality of the renal cortex (HP:0011035)3.47149201
8True hermaphroditism (HP:0010459)3.42948208
9Medial flaring of the eyebrow (HP:0010747)3.33649250
10Volvulus (HP:0002580)3.15774970
11Gait imbalance (HP:0002141)3.03151330
12Hepatoblastoma (HP:0002884)3.03011093
13Macroorchidism (HP:0000053)2.92298453
14Excessive salivation (HP:0003781)2.90614521
15Drooling (HP:0002307)2.90614521
16Renal cortical cysts (HP:0000803)2.89704275
17Abnormality of the nasal septum (HP:0000419)2.82276981
18Papillary thyroid carcinoma (HP:0002895)2.79527867
19Febrile seizures (HP:0002373)2.78636060
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.74958334
21Absent/shortened dynein arms (HP:0200106)2.74958334
22Cystic liver disease (HP:0006706)2.72267523
23Abnormality of the fingertips (HP:0001211)2.70933459
24Congenital primary aphakia (HP:0007707)2.67817333
25Protruding tongue (HP:0010808)2.64933906
26Tubulointerstitial nephritis (HP:0001970)2.62491923
27Genetic anticipation (HP:0003743)2.61258630
28Abnormal respiratory motile cilium morphology (HP:0005938)2.55478837
29Abnormal respiratory epithelium morphology (HP:0012253)2.55478837
30Midline defect of the nose (HP:0004122)2.55023259
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51814378
32Abnormal ciliary motility (HP:0012262)2.50524855
33Type II lissencephaly (HP:0007260)2.50410865
34Chronic hepatic failure (HP:0100626)2.46870689
35Genital tract atresia (HP:0001827)2.46679923
36Progressive cerebellar ataxia (HP:0002073)2.46554984
37Nephrogenic diabetes insipidus (HP:0009806)2.45765558
38Postaxial foot polydactyly (HP:0001830)2.40514075
39Obsessive-compulsive behavior (HP:0000722)2.39870981
40Poor coordination (HP:0002370)2.38178594
41Vaginal atresia (HP:0000148)2.36953527
42Abnormal respiratory motile cilium physiology (HP:0012261)2.36470142
43Exotropia (HP:0000577)2.31669122
44Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28508634
45Short 4th metacarpal (HP:0010044)2.28508634
46Absent eyebrow (HP:0002223)2.27467404
47Narrow palate (HP:0000189)2.26253365
48Fair hair (HP:0002286)2.25321039
49Tubular atrophy (HP:0000092)2.24815134
50Broad-based gait (HP:0002136)2.24639193
51Congenital hepatic fibrosis (HP:0002612)2.21708523
52Rhinitis (HP:0012384)2.21032779
53Cutaneous finger syndactyly (HP:0010554)2.17794416
54Truncal obesity (HP:0001956)2.14974438
55Hypothermia (HP:0002045)2.14811894
56Postaxial hand polydactyly (HP:0001162)2.13976716
57Focal seizures (HP:0007359)2.13211380
58Lip pit (HP:0100267)2.12858701
59Atonic seizures (HP:0010819)2.12831907
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12288932
61Abnormality of salivation (HP:0100755)2.06297201
62Abnormal biliary tract physiology (HP:0012439)2.05647672
63Bile duct proliferation (HP:0001408)2.05647672
64Blue irides (HP:0000635)2.05424434
65Epileptic encephalopathy (HP:0200134)2.03230055
66Limb dystonia (HP:0002451)2.02708923
67Open mouth (HP:0000194)2.02146098
68Intestinal atresia (HP:0011100)2.01153218
69Dialeptic seizures (HP:0011146)2.00922991
70Tubulointerstitial abnormality (HP:0001969)2.00918396
71Hyperventilation (HP:0002883)2.00249736
72Neoplasm of the adrenal cortex (HP:0100641)2.00210941
73Abnormal hair whorl (HP:0010721)1.99851350
74Subacute progressive viral hepatitis (HP:0006572)1.99730785
75Morphological abnormality of the middle ear (HP:0008609)1.99616151
76Lissencephaly (HP:0001339)1.99278561
77Pachygyria (HP:0001302)1.98561319
78Hypoplastic labia majora (HP:0000059)1.97930110
79Urethral obstruction (HP:0000796)1.97013264
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.96747828
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.96384155
82Cutaneous syndactyly (HP:0012725)1.95995527
83Renal hypoplasia (HP:0000089)1.95848259
84Long eyelashes (HP:0000527)1.93631635
85Long clavicles (HP:0000890)1.92309772
86Elfin facies (HP:0004428)1.91919692
87Male pseudohermaphroditism (HP:0000037)1.91269382
88Inability to walk (HP:0002540)1.91150974
89Aqueductal stenosis (HP:0002410)1.89400954
90Occipital encephalocele (HP:0002085)1.86296792
91Abnormal drinking behavior (HP:0030082)1.85757999
92Polydipsia (HP:0001959)1.85757999
93Hypoplastic nipples (HP:0002557)1.85692540
94Labial hypoplasia (HP:0000066)1.85433158
95Focal motor seizures (HP:0011153)1.85408740
96Highly arched eyebrow (HP:0002553)1.84649173
97Urinary bladder sphincter dysfunction (HP:0002839)1.84552315
98Absent frontal sinuses (HP:0002688)1.84251102
99Polyphagia (HP:0002591)1.83451991
100Anencephaly (HP:0002323)1.83239859
101Smooth philtrum (HP:0000319)1.81797476
102Decreased lacrimation (HP:0000633)1.81094126
103Scanning speech (HP:0002168)1.80364213
104Hypoplastic ischia (HP:0003175)1.79940239
105Short foot (HP:0001773)1.79472653
106Abnormality of the labia majora (HP:0012881)1.78553318
107Decreased circulating renin level (HP:0003351)1.78384249
108Congenital stationary night blindness (HP:0007642)1.78325658
109Heterotopia (HP:0002282)1.78164167
110Sclerocornea (HP:0000647)1.77737084
111Thick eyebrow (HP:0000574)1.77733175
112Laryngomalacia (HP:0001601)1.77120293
113Lower limb amyotrophy (HP:0007210)1.77001772
114Specific learning disability (HP:0001328)1.76687780
115Gaze-evoked nystagmus (HP:0000640)1.76284016
116Abnormal pancreas size (HP:0012094)1.75505492
117Widely spaced teeth (HP:0000687)1.73621619
118Inappropriate behavior (HP:0000719)1.73579196
119Transitional cell carcinoma of the bladder (HP:0006740)1.72985075
120Anal stenosis (HP:0002025)1.71910695
121Overgrowth (HP:0001548)1.71845110
122Prominent nasal bridge (HP:0000426)1.70937207
123Alacrima (HP:0000522)1.70291747
124Stomach cancer (HP:0012126)1.69896372
125Action tremor (HP:0002345)1.68095690
126Abnormality of the pubic bones (HP:0003172)1.67968905
127Germ cell neoplasia (HP:0100728)1.67733029
128Bifid tongue (HP:0010297)1.67607210
129Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.67199140
130Oculomotor apraxia (HP:0000657)1.66746157
131Tented upper lip vermilion (HP:0010804)1.66191891
132Optic nerve hypoplasia (HP:0000609)1.65981978
133Truncal ataxia (HP:0002078)1.65166787
134Gastroesophageal reflux (HP:0002020)1.65045103
135Calf muscle hypertrophy (HP:0008981)1.64714087
136Progressive sensorineural hearing impairment (HP:0000408)1.64300690
137EEG with generalized epileptiform discharges (HP:0011198)1.63890787
138Generalized hypopigmentation of hair (HP:0011358)1.63487274
139Short chin (HP:0000331)1.63104396
140Absent speech (HP:0001344)1.62845499
141Intellectual disability, moderate (HP:0002342)1.61541633
142Abnormality of the ischium (HP:0003174)1.60998590
143Abnormality of incisor morphology (HP:0011063)1.60739049
144Intellectual disability, severe (HP:0010864)1.60126669
145Epileptiform EEG discharges (HP:0011182)1.59684585
146Preaxial hand polydactyly (HP:0001177)1.59388946
147Cupped ear (HP:0000378)1.59311909
148Renovascular hypertension (HP:0100817)1.59270459
149Thyroid carcinoma (HP:0002890)1.59204704
150Bladder neoplasm (HP:0009725)1.59079644
151Bladder carcinoma (HP:0002862)1.59079644
152Agitation (HP:0000713)1.58880563
153Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58525098
154Degeneration of the lateral corticospinal tracts (HP:0002314)1.58525098
155Furrowed tongue (HP:0000221)1.58487161
156Impaired smooth pursuit (HP:0007772)1.57587571
157Hypsarrhythmia (HP:0002521)1.55374858
158Leiomyosarcoma (HP:0100243)1.55325451
159Uterine leiomyosarcoma (HP:0002891)1.55325451
160Autism (HP:0000717)1.54928017
161Increased number of teeth (HP:0011069)1.54136288
162Central scotoma (HP:0000603)1.53276306
163Deep philtrum (HP:0002002)1.52541013
164Trigonocephaly (HP:0000243)1.49983139
165Stereotypic behavior (HP:0000733)1.49082541
166Abnormality of the 4th metacarpal (HP:0010012)1.49074516
167Narrow forehead (HP:0000341)1.48964051
168Vesicoureteral reflux (HP:0000076)1.48620368
169Oligodactyly (hands) (HP:0001180)1.48395804
170Abnormality of the corticospinal tract (HP:0002492)1.48162969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.13403143
2INSRR3.43861271
3FRK2.92032872
4CAMK1G2.47648667
5NTRK32.15707923
6EPHA42.06702697
7CAMK1D2.03266472
8SIK22.02334112
9SGK22.00489951
10MAPK131.98609831
11ACVR1B1.92945506
12TNIK1.90818778
13BRD41.90647535
14LATS11.85396960
15MAP3K41.83853399
16CASK1.81902481
17AKT31.78606323
18MAP4K21.77262132
19NUAK11.70172395
20ERBB31.69757578
21PINK11.68812556
22NTRK21.60269817
23FGFR21.59355702
24SGK31.56550469
25CDK121.51475362
26STK391.48109089
27SGK4941.47946692
28SGK2231.47946692
29WNK41.47134428
30MARK21.30512708
31MAP2K71.27578647
32DMPK1.25064423
33WNK31.24373297
34PIK3CA1.20183699
35GRK11.17623624
36OXSR11.17234095
37KSR11.16599368
38PKN11.13252427
39PHKG11.10170839
40PHKG21.10170839
41ADRBK21.08274434
42CDK31.07020919
43CSNK1A1L1.06243132
44BCR1.03829341
45CAMKK21.02655802
46SGK11.00086772
47BMPR1B0.97075613
48PNCK0.94121086
49MAP3K20.91869460
50TAOK30.91686070
51MAPK150.85973343
52CDC42BPA0.85702897
53FGFR30.83910443
54EPHB20.83496502
55CCNB10.83345267
56STK110.82202076
57SIK10.81732186
58PRKCG0.77386510
59CDK50.77264966
60RIPK10.76890935
61HIPK20.76484697
62LMTK20.75338408
63CSNK1G20.75030466
64CAMK40.74790279
65RPS6KA20.73798861
66FER0.72721250
67PRKCE0.72380197
68WNK10.72256744
69TRIM280.70877413
70EPHA30.70503435
71ZAK0.70187519
72STK38L0.70144315
73PAK30.69308847
74ERBB20.68514958
75BRSK20.66697431
76DAPK20.66633490
77MINK10.63818887
78TLK10.63245615
79PIK3CG0.62272028
80PRKAA20.61494522
81PRKAA10.61059604
82CAMK10.60432396
83PDGFRB0.59645177
84RPS6KB10.59633819
85ADRBK10.59261664
86DYRK1A0.59252133
87CDK90.58952859
88YES10.58833084
89PRKG10.58295080
90MAP3K120.57724679
91UHMK10.56663024
92CSNK1G10.56050761
93DYRK20.55949339
94TNK20.55569864
95PRKCH0.55255503
96OBSCN0.55144443
97PTK60.54058784
98MKNK20.53943482
99TEC0.53630245
100GSK3B0.52419542
101MAPK80.51611577
102RPS6KA30.51240148
103MAP3K60.51136859
104MAP2K40.48804243
105NEK60.48201654
106MAP3K70.48078839
107PLK20.47171246
108PRKCZ0.47051285
109TIE10.46659675
110EIF2AK20.46552886
111PRKCB0.46223801
112MAPK100.46145107
113* PRKACA0.45768622
114CSNK1E0.45659978
115ROCK10.45559752
116MTOR0.45097668
117SIK30.45092432
118ATM0.43633947
119MAPK140.43272777
120CAMK2A0.42938162
121NLK0.42105256
122CSNK1D0.41384287
123ICK0.41105666
124BMPR20.40888564
125JAK10.40475742
126MUSK0.40134056
127PTK2B0.39984422
128PRKACB0.39579619
129CSNK1A10.36747525
130CSNK1G30.35621838
131TRPM70.35132907
132MKNK10.33238342

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.15577624
2Nicotine addiction_Homo sapiens_hsa050332.11232029
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05344505
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94674934
5Butanoate metabolism_Homo sapiens_hsa006501.91659168
6Circadian entrainment_Homo sapiens_hsa047131.90603753
7Caffeine metabolism_Homo sapiens_hsa002321.87868171
8Type II diabetes mellitus_Homo sapiens_hsa049301.84816877
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84246350
10Morphine addiction_Homo sapiens_hsa050321.80898181
11Insulin secretion_Homo sapiens_hsa049111.79352974
12Glutamatergic synapse_Homo sapiens_hsa047241.76615436
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75334052
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71641513
15Nitrogen metabolism_Homo sapiens_hsa009101.68550841
16Axon guidance_Homo sapiens_hsa043601.65571836
17Long-term potentiation_Homo sapiens_hsa047201.64574419
18Olfactory transduction_Homo sapiens_hsa047401.62427125
19Cholinergic synapse_Homo sapiens_hsa047251.61209978
20Renin secretion_Homo sapiens_hsa049241.60032743
21GABAergic synapse_Homo sapiens_hsa047271.58973378
22Cocaine addiction_Homo sapiens_hsa050301.56130431
23Taste transduction_Homo sapiens_hsa047421.54849161
24Phototransduction_Homo sapiens_hsa047441.54568225
25Dopaminergic synapse_Homo sapiens_hsa047281.52694876
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49063470
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48438285
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.47120772
29Ether lipid metabolism_Homo sapiens_hsa005651.44515598
30Amphetamine addiction_Homo sapiens_hsa050311.43879888
31Salivary secretion_Homo sapiens_hsa049701.40193736
32Serotonergic synapse_Homo sapiens_hsa047261.39275661
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36552472
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.33769071
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33710735
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30770209
37Lysine degradation_Homo sapiens_hsa003101.30415948
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29984308
39Endometrial cancer_Homo sapiens_hsa052131.29235390
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24709666
41Gastric acid secretion_Homo sapiens_hsa049711.24648240
42cAMP signaling pathway_Homo sapiens_hsa040241.24285910
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23480715
44ErbB signaling pathway_Homo sapiens_hsa040121.22392031
45Propanoate metabolism_Homo sapiens_hsa006401.21944354
46Chemical carcinogenesis_Homo sapiens_hsa052041.21736775
47Protein export_Homo sapiens_hsa030601.21574024
48Long-term depression_Homo sapiens_hsa047301.19138742
49Oxytocin signaling pathway_Homo sapiens_hsa049211.18612247
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18417695
51Retinol metabolism_Homo sapiens_hsa008301.17538425
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14164958
53Melanogenesis_Homo sapiens_hsa049161.12373043
54Dilated cardiomyopathy_Homo sapiens_hsa054141.12365620
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12293912
56Calcium signaling pathway_Homo sapiens_hsa040201.09756045
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.08836578
58Tryptophan metabolism_Homo sapiens_hsa003801.08438968
59Dorso-ventral axis formation_Homo sapiens_hsa043201.06719368
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05588538
61Gap junction_Homo sapiens_hsa045401.04986044
62Circadian rhythm_Homo sapiens_hsa047101.03648794
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02796736
64Basal cell carcinoma_Homo sapiens_hsa052171.01809532
65Wnt signaling pathway_Homo sapiens_hsa043101.01178169
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00391567
67Peroxisome_Homo sapiens_hsa041460.99991678
68GnRH signaling pathway_Homo sapiens_hsa049120.99703148
69Estrogen signaling pathway_Homo sapiens_hsa049150.98488677
70Glioma_Homo sapiens_hsa052140.98315167
71Cardiac muscle contraction_Homo sapiens_hsa042600.96837257
72Fanconi anemia pathway_Homo sapiens_hsa034600.95636489
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95561849
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94427997
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92852438
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92601376
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91157901
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90302204
79Pancreatic secretion_Homo sapiens_hsa049720.90157837
80Steroid biosynthesis_Homo sapiens_hsa001000.89138600
81Fatty acid biosynthesis_Homo sapiens_hsa000610.88713059
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88142359
83Basal transcription factors_Homo sapiens_hsa030220.87312217
84Adherens junction_Homo sapiens_hsa045200.87274146
85Regulation of autophagy_Homo sapiens_hsa041400.87240014
86Choline metabolism in cancer_Homo sapiens_hsa052310.86825217
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86506338
88Hedgehog signaling pathway_Homo sapiens_hsa043400.84391239
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.84382537
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84187620
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83828803
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82675365
93Colorectal cancer_Homo sapiens_hsa052100.82595543
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81692414
95Inositol phosphate metabolism_Homo sapiens_hsa005620.80037166
96Non-small cell lung cancer_Homo sapiens_hsa052230.79822273
97Ovarian steroidogenesis_Homo sapiens_hsa049130.79572147
98Thyroid hormone synthesis_Homo sapiens_hsa049180.79269452
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78846657
100MAPK signaling pathway_Homo sapiens_hsa040100.77502641
101Histidine metabolism_Homo sapiens_hsa003400.76908127
102Glucagon signaling pathway_Homo sapiens_hsa049220.76260123
103Renal cell carcinoma_Homo sapiens_hsa052110.75160538
104Prostate cancer_Homo sapiens_hsa052150.75134665
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72897227
106Rap1 signaling pathway_Homo sapiens_hsa040150.71838901
107Ras signaling pathway_Homo sapiens_hsa040140.71376085
108Insulin resistance_Homo sapiens_hsa049310.70675993
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68725587
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.68521856
111Prolactin signaling pathway_Homo sapiens_hsa049170.68342577
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68164810
113mTOR signaling pathway_Homo sapiens_hsa041500.67675477
114MicroRNAs in cancer_Homo sapiens_hsa052060.67266634
115Vitamin digestion and absorption_Homo sapiens_hsa049770.66593963
116Alcoholism_Homo sapiens_hsa050340.64876523
117FoxO signaling pathway_Homo sapiens_hsa040680.64100740
118Tight junction_Homo sapiens_hsa045300.62377616
119Insulin signaling pathway_Homo sapiens_hsa049100.61815752
120Fat digestion and absorption_Homo sapiens_hsa049750.61359102
121Synaptic vesicle cycle_Homo sapiens_hsa047210.58614159
122ABC transporters_Homo sapiens_hsa020100.57869574
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.57712186
124Focal adhesion_Homo sapiens_hsa045100.56956297
125Glycerolipid metabolism_Homo sapiens_hsa005610.56926893
126Melanoma_Homo sapiens_hsa052180.55842467
127Oxidative phosphorylation_Homo sapiens_hsa001900.53725632
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52834735
129RNA degradation_Homo sapiens_hsa030180.52810128
130Chronic myeloid leukemia_Homo sapiens_hsa052200.52649143
131Viral myocarditis_Homo sapiens_hsa054160.51987136
132Pancreatic cancer_Homo sapiens_hsa052120.51310415
133Hippo signaling pathway_Homo sapiens_hsa043900.51102351
134beta-Alanine metabolism_Homo sapiens_hsa004100.50995781
135ECM-receptor interaction_Homo sapiens_hsa045120.50886231
136Pathways in cancer_Homo sapiens_hsa052000.50747061
137Proteoglycans in cancer_Homo sapiens_hsa052050.50600001
138AMPK signaling pathway_Homo sapiens_hsa041520.48729157
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48359327
140Homologous recombination_Homo sapiens_hsa034400.47436372
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46978065
142Mineral absorption_Homo sapiens_hsa049780.45846778
143Bile secretion_Homo sapiens_hsa049760.45053383
144Starch and sucrose metabolism_Homo sapiens_hsa005000.43540461
145Collecting duct acid secretion_Homo sapiens_hsa049660.42855963
146Selenocompound metabolism_Homo sapiens_hsa004500.40588237
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39224138

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