AKNAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a domain found in an AT-hook-containing transcription factor. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein targeting to Golgi (GO:0000042)7.35522127
2establishment of protein localization to Golgi (GO:0072600)7.24500933
3protein polyglutamylation (GO:0018095)7.17181966
4retrograde transport, vesicle recycling within Golgi (GO:0000301)6.80419208
5sperm capacitation (GO:0048240)6.24762931
6DNA packaging (GO:0006323)6.02441311
7chromosome condensation (GO:0030261)6.02090051
8response to pheromone (GO:0019236)5.92358542
9single strand break repair (GO:0000012)5.90900960
10calcium ion-dependent exocytosis (GO:0017156)5.58230977
11protein localization to Golgi apparatus (GO:0034067)5.54501963
12piRNA metabolic process (GO:0034587)5.47777958
13spermatogenesis (GO:0007283)5.44513160
14male gamete generation (GO:0048232)5.43243213
15seminiferous tubule development (GO:0072520)5.42483680
16multicellular organism reproduction (GO:0032504)5.41419101
17spermatid nucleus differentiation (GO:0007289)5.36387768
18regulation of centriole replication (GO:0046599)5.09127868
19phosphatidylethanolamine biosynthetic process (GO:0006646)5.01005195
20microtubule severing (GO:0051013)4.84844721
21phosphatidylethanolamine metabolic process (GO:0046337)4.77819054
22regulation of female gonad development (GO:2000194)4.47131699
23DNA methylation involved in gamete generation (GO:0043046)4.42380837
24axonemal dynein complex assembly (GO:0070286)4.34064906
25RNA destabilization (GO:0050779)4.33858541
26female gonad development (GO:0008585)4.27295152
27centriole assembly (GO:0098534)4.23632289
28male meiosis (GO:0007140)4.22951210
29microtubule depolymerization (GO:0007019)4.22520999
30epithelial cilium movement (GO:0003351)4.19725625
31germ cell development (GO:0007281)4.18219548
32organic cation transport (GO:0015695)4.13488356
33negative regulation of inclusion body assembly (GO:0090084)4.06399435
34cilium movement (GO:0003341)4.04697077
35motile cilium assembly (GO:0044458)4.04608451
36cellular ketone body metabolic process (GO:0046950)4.03438394
37cilium or flagellum-dependent cell motility (GO:0001539)3.96391537
38multicellular organismal reproductive process (GO:0048609)3.93695898
39reproduction (GO:0000003)3.91225161
40meiotic cell cycle (GO:0051321)3.87884182
41multicellular organismal movement (GO:0050879)3.84900525
42musculoskeletal movement (GO:0050881)3.84900525
43cellular process involved in reproduction in multicellular organism (GO:0022412)3.76052522
44centriole replication (GO:0007099)3.75430001
45regulation of Rab GTPase activity (GO:0032313)3.74569992
46positive regulation of Rab GTPase activity (GO:0032851)3.74569992
47meiotic chromosome segregation (GO:0045132)3.71351777
48kinetochore assembly (GO:0051382)3.61252309
49ketone body metabolic process (GO:1902224)3.60016151
50microtubule nucleation (GO:0007020)3.59625843
51glomerular visceral epithelial cell development (GO:0072015)3.49670551
52intra-Golgi vesicle-mediated transport (GO:0006891)3.48849828
53kinetochore organization (GO:0051383)3.46451330
54coenzyme catabolic process (GO:0009109)3.45561085
55rRNA methylation (GO:0031167)3.42111935
56single fertilization (GO:0007338)3.38061836
57sperm-egg recognition (GO:0035036)3.34026402
58negative regulation of Rho protein signal transduction (GO:0035024)3.32774136
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31323525
60regulation of mitotic spindle checkpoint (GO:1903504)3.31323525
61regulation of phosphoprotein phosphatase activity (GO:0043666)3.28657740
62male meiosis I (GO:0007141)3.26792219
63regulation of transcription involved in cell fate commitment (GO:0060850)3.25191971
64regulation of microtubule-based movement (GO:0060632)3.24865041
65negative regulation of meiosis (GO:0045835)3.22823086
66female gamete generation (GO:0007292)3.19425694
67glomerular epithelial cell development (GO:0072310)3.19372732
68mesenchymal cell differentiation involved in kidney development (GO:0072161)3.18248623
69mesenchymal cell differentiation involved in renal system development (GO:2001012)3.18248623
70sperm motility (GO:0030317)3.14878978
71sexual reproduction (GO:0019953)3.13849829
72positive regulation of guanylate cyclase activity (GO:0031284)3.11929393
73superoxide anion generation (GO:0042554)3.11852525
74regulation of meiosis (GO:0040020)3.11483906
75binding of sperm to zona pellucida (GO:0007339)3.08860062
76fertilization (GO:0009566)3.07451043
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04981359
78retinal cone cell development (GO:0046549)3.03532577
79cell wall macromolecule catabolic process (GO:0016998)3.00966469
80cell wall macromolecule metabolic process (GO:0044036)3.00966469
81regulation of timing of cell differentiation (GO:0048505)2.98641548
82fusion of sperm to egg plasma membrane (GO:0007342)2.96379783
83nonmotile primary cilium assembly (GO:0035058)2.94359109
84acrosome reaction (GO:0007340)2.94172909
85regulation of meiosis I (GO:0060631)2.94155259
86rRNA modification (GO:0000154)2.89215656
87cell recognition (GO:0008037)2.86585495
88regulation of meiotic cell cycle (GO:0051445)2.85456162
89myoblast migration (GO:0051451)2.84960313
90cell-cell recognition (GO:0009988)2.83945388
91regulation of guanylate cyclase activity (GO:0031282)2.82564579
92cellular response to gamma radiation (GO:0071480)2.81488929
93limb bud formation (GO:0060174)2.80300876
94positive regulation of meiotic cell cycle (GO:0051446)2.79639643
95behavioral response to nicotine (GO:0035095)2.79312551
96ventricular system development (GO:0021591)2.78648280
97negative regulation of homotypic cell-cell adhesion (GO:0034111)2.78339292
98regulation of inclusion body assembly (GO:0090083)2.76844479
99positive regulation of meiosis (GO:0045836)2.74997316
100nucleus organization (GO:0006997)2.74835999
101negative regulation of keratinocyte proliferation (GO:0010839)2.74678836
102cilium assembly (GO:0042384)2.72571797
103spinal cord motor neuron differentiation (GO:0021522)2.72046876
104cilium organization (GO:0044782)2.71582374
105replicative senescence (GO:0090399)2.71402857
106notochord development (GO:0030903)2.70952276
107regulation of acrosome reaction (GO:0060046)2.70862761
108regulation of activation of Janus kinase activity (GO:0010533)2.70652595
109positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.70372878
110regulation of non-canonical Wnt signaling pathway (GO:2000050)2.70260490
111daunorubicin metabolic process (GO:0044597)2.69304969
112polyketide metabolic process (GO:0030638)2.69304969
113doxorubicin metabolic process (GO:0044598)2.69304969
114regulation of male gonad development (GO:2000018)2.68811559
115detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.68549917
116Golgi to endosome transport (GO:0006895)2.67884185
117tryptophan catabolic process (GO:0006569)2.67068871
118indole-containing compound catabolic process (GO:0042436)2.67068871
119indolalkylamine catabolic process (GO:0046218)2.67068871
120regulation of cilium movement (GO:0003352)2.66710661
121regulation of histone H3-K27 methylation (GO:0061085)2.66554106
122regulation of development, heterochronic (GO:0040034)2.66358608
123protein K11-linked deubiquitination (GO:0035871)2.65747975
124protein K6-linked ubiquitination (GO:0085020)2.65488719
125multicellular organismal development (GO:0007275)2.64291836
126DNA synthesis involved in DNA repair (GO:0000731)2.63088488
127synapsis (GO:0007129)2.62987570
128microtubule bundle formation (GO:0001578)2.62884692
129acrosome assembly (GO:0001675)2.62872433
130peptidyl-glutamic acid modification (GO:0018200)2.62334077
131negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.61664280
132negative regulation of mast cell activation (GO:0033004)2.61037497
133oocyte maturation (GO:0001556)2.60706600
134glycerol ether metabolic process (GO:0006662)2.60322999
135microtubule polymerization or depolymerization (GO:0031109)2.59940697
136intra-S DNA damage checkpoint (GO:0031573)2.59536917
137positive regulation of megakaryocyte differentiation (GO:0045654)2.58445200
138detection of light stimulus involved in sensory perception (GO:0050962)2.57672481
139detection of light stimulus involved in visual perception (GO:0050908)2.57672481
140nucleoside diphosphate catabolic process (GO:0009134)2.56280767
141regulation of spindle checkpoint (GO:0090231)2.55429029
142detection of other organism (GO:0098543)2.55150509
143CENP-A containing nucleosome assembly (GO:0034080)2.55021835
144axoneme assembly (GO:0035082)2.53455721
145chromatin remodeling at centromere (GO:0031055)2.52975304
146meiosis I (GO:0007127)2.52714685
147energy homeostasis (GO:0097009)2.52530489
148regulation of hypersensitivity (GO:0002883)2.51694666
149sphingoid metabolic process (GO:0046519)2.50809055
150chromosome organization involved in meiosis (GO:0070192)2.50377006
151detection of bacterium (GO:0016045)2.48813257
152gamete generation (GO:0007276)2.47830760
153pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.47779468
154negative regulation of meiotic cell cycle (GO:0051447)2.47708249
155neural crest cell development (GO:0014032)2.45900979
156plasma membrane fusion (GO:0045026)2.45255514
157righting reflex (GO:0060013)2.45022979
158cartilage morphogenesis (GO:0060536)2.43810276
159otic vesicle formation (GO:0030916)2.43321992
160sulfate transport (GO:0008272)2.40819532
161response to X-ray (GO:0010165)2.40734170
162spermatid development (GO:0007286)2.40714056
163negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.39757173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82680640
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.57298867
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.29324781
4EZH2_22144423_ChIP-Seq_EOC_Human3.27942378
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.23081230
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14894824
7GBX2_23144817_ChIP-Seq_PC3_Human2.97203035
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.93171546
9ZNF274_21170338_ChIP-Seq_K562_Hela2.76431108
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.62895648
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59385478
12NFE2_27457419_Chip-Seq_LIVER_Mouse2.52675192
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.35289366
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.31439703
15VDR_22108803_ChIP-Seq_LS180_Human2.30070351
16IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.24658018
17CBP_20019798_ChIP-Seq_JUKART_Human2.24658018
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17197449
19EZH2_27294783_Chip-Seq_NPCs_Mouse2.17162648
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06320249
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.03197633
22EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.02255855
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02087807
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.95579278
25* STAT3_18555785_Chip-Seq_ESCs_Mouse1.91557108
26IGF1R_20145208_ChIP-Seq_DFB_Human1.90807762
27KAP1_22055183_ChIP-Seq_ESCs_Mouse1.89718096
28P53_22387025_ChIP-Seq_ESCs_Mouse1.89357820
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.89308652
30SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82797265
31RNF2_27304074_Chip-Seq_NSC_Mouse1.81463360
32NMYC_18555785_Chip-Seq_ESCs_Mouse1.78335187
33EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77891265
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76540160
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76096535
36* E2F1_18555785_Chip-Seq_ESCs_Mouse1.76019323
37FUS_26573619_Chip-Seq_HEK293_Human1.75532386
38CMYC_18555785_Chip-Seq_ESCs_Mouse1.70613476
39OCT4_18555785_Chip-Seq_ESCs_Mouse1.69414664
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69158275
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.68418672
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68066862
43SOX2_18555785_Chip-Seq_ESCs_Mouse1.67595369
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.65572305
45RUNX1_27457419_Chip-Seq_LIVER_Mouse1.64582913
46* P300_18555785_Chip-Seq_ESCs_Mouse1.64140530
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.64053029
48P300_19829295_ChIP-Seq_ESCs_Human1.63829393
49ESRRB_18555785_Chip-Seq_ESCs_Mouse1.62860472
50AR_21572438_ChIP-Seq_LNCaP_Human1.62210267
51KLF4_18555785_Chip-Seq_ESCs_Mouse1.61384365
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60418362
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59154720
54* ZFX_18555785_Chip-Seq_ESCs_Mouse1.57959712
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57625441
56PU1_27457419_Chip-Seq_LIVER_Mouse1.56178968
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.54982392
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.53823364
59TAF15_26573619_Chip-Seq_HEK293_Human1.52930896
60EWS_26573619_Chip-Seq_HEK293_Human1.51802414
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50505958
62CTCF_18555785_Chip-Seq_ESCs_Mouse1.48892692
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.48534962
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.47830761
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47157545
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46997442
67RAC3_21632823_ChIP-Seq_H3396_Human1.44909476
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.42976025
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.42456011
70TP53_18474530_ChIP-ChIP_U2OS_Human1.42411114
71ERA_21632823_ChIP-Seq_H3396_Human1.42401175
72SMAD1_18555785_Chip-Seq_ESCs_Mouse1.41216521
73* MYC_19829295_ChIP-Seq_ESCs_Human1.39554705
74E2F7_22180533_ChIP-Seq_HELA_Human1.39402703
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.38481084
76STAT1_17558387_ChIP-Seq_HELA_Human1.37388929
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36613779
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.35555718
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35466374
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.35032023
81KDM2B_26808549_Chip-Seq_REH_Human1.33785028
82SMAD4_21799915_ChIP-Seq_A2780_Human1.33496249
83* RBPJ_21746931_ChIP-Seq_IB4_Human1.33146453
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32944272
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.32427733
86SOX2_19829295_ChIP-Seq_ESCs_Human1.31955587
87NANOG_19829295_ChIP-Seq_ESCs_Human1.31955587
88* TBL1_22424771_ChIP-Seq_293T_Human1.30916827
89NANOG_20526341_ChIP-Seq_ESCs_Human1.30911335
90* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30025293
91WDR5_24793694_ChIP-Seq_LNCAP_Human1.27902229
92* ETV1_20927104_ChIP-Seq_GIST48_Human1.27535399
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26660068
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24496014
95* HNFA_21074721_ChIP-Seq_CACO-2_Human1.22423815
96* NFYB_21822215_ChIP-Seq_K562_Human1.22180203
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21431907
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20764536
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20314440
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20288722
101* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19047541
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18840806
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18840806
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17189185
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.17084374
106TAF2_19829295_ChIP-Seq_ESCs_Human1.16797765
107ERG_20517297_ChIP-Seq_VCAP_Human1.16719918
108DROSHA_22980978_ChIP-Seq_HELA_Human1.16718736
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16033884
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15745093
111* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15487471
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15351417
113EED_16625203_ChIP-ChIP_MESCs_Mouse1.15193576
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14903780
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.14821876
116ER_23166858_ChIP-Seq_MCF-7_Human1.14560225
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.14458739
118BP1_19119308_ChIP-ChIP_Hs578T_Human1.14412524
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14157464
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.13493500
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13493500
122HOXB7_26014856_ChIP-Seq_BT474_Human1.12387725
123STAT3_23295773_ChIP-Seq_U87_Human1.12377468
124OCT4_20526341_ChIP-Seq_ESCs_Human1.12011025
125TCF4_22108803_ChIP-Seq_LS180_Human1.11093304
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10542241
127REST_21632747_ChIP-Seq_MESCs_Mouse1.09786530
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09740942
129* GF1B_26923725_Chip-Seq_HPCs_Mouse1.09725546
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.09318850
131GATA1_26923725_Chip-Seq_HPCs_Mouse1.08728045
132CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08234903
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07793918
134EZH2_27304074_Chip-Seq_ESCs_Mouse1.07193916
135TCF4_23295773_ChIP-Seq_U87_Human1.06748597
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06657831
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06580028
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06188630
139* GATA6_21074721_ChIP-Seq_CACO-2_Human1.05975801
140TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05701522
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.04043611
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02237926
143* NFYA_21822215_ChIP-Seq_K562_Human1.01391308
144* NCOR_22424771_ChIP-Seq_293T_Human1.01256803
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99631119
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98447380
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98025481
148* GF1_26923725_Chip-Seq_HPCs_Mouse0.96466333
149RUNX2_22187159_ChIP-Seq_PCA_Human0.96432549
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96029618
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95917762
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95729834
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94376336
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93575911
155* PHF8_20622853_ChIP-Seq_HELA_Human0.93404736
156AR_25329375_ChIP-Seq_VCAP_Human0.92749556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.67296609
2MP0003878_abnormal_ear_physiology3.56324954
3MP0005377_hearing/vestibular/ear_phenot3.56324954
4MP0006292_abnormal_olfactory_placode3.42560293
5MP0001188_hyperpigmentation3.32794430
6MP0003718_maternal_effect3.01463282
7MP0002102_abnormal_ear_morphology2.99801549
8MP0000566_synostosis2.93146528
9MP0001986_abnormal_taste_sensitivity2.91526269
10MP0003941_abnormal_skin_development2.69625421
11MP0010386_abnormal_urinary_bladder2.68187025
12MP0003787_abnormal_imprinting2.61585021
13MP0004381_abnormal_hair_follicle2.42961888
14MP0008877_abnormal_DNA_methylation2.34037725
15MP0005410_abnormal_fertilization2.31741813
16MP0002132_abnormal_respiratory_system2.30928594
17MP0002163_abnormal_gland_morphology2.20872089
18MP0008058_abnormal_DNA_repair2.19980076
19MP0004782_abnormal_surfactant_physiolog2.16231490
20MP0001486_abnormal_startle_reflex2.11914397
21MP0005646_abnormal_pituitary_gland2.10346464
22MP0002249_abnormal_larynx_morphology2.05894586
23MP0002277_abnormal_respiratory_mucosa2.00738286
24MP0009697_abnormal_copulation1.94960917
25MP0001968_abnormal_touch/_nociception1.93400542
26MP0010094_abnormal_chromosome_stability1.83358482
27MP0001119_abnormal_female_reproductive1.82714902
28MP0001929_abnormal_gametogenesis1.80633977
29MP0002638_abnormal_pupillary_reflex1.75600325
30MP0005451_abnormal_body_composition1.73945239
31MP0001485_abnormal_pinna_reflex1.73735806
32MP0001348_abnormal_lacrimal_gland1.72933057
33MP0005379_endocrine/exocrine_gland_phen1.72467012
34MP0008004_abnormal_stomach_pH1.72249022
35MP0005171_absent_coat_pigmentation1.61651269
36MP0001346_abnormal_lacrimal_gland1.60950669
37MP0002210_abnormal_sex_determination1.58626417
38MP0005423_abnormal_somatic_nervous1.54245230
39MP0005394_taste/olfaction_phenotype1.50016428
40MP0005499_abnormal_olfactory_system1.50016428
41MP0008995_early_reproductive_senescence1.49795261
42MP0008007_abnormal_cellular_replicative1.45992274
43MP0009745_abnormal_behavioral_response1.45391659
44MP0009250_abnormal_appendicular_skeleto1.44799611
45MP0000383_abnormal_hair_follicle1.44760442
46MP0005409_darkened_coat_color1.44161496
47MP0003698_abnormal_male_reproductive1.43290704
48MP0002735_abnormal_chemical_nociception1.43091155
49MP0002234_abnormal_pharynx_morphology1.41749845
50MP0001905_abnormal_dopamine_level1.38715238
51MP0003693_abnormal_embryo_hatching1.38177650
52MP0000653_abnormal_sex_gland1.35568333
53MP0000579_abnormal_nail_morphology1.32649951
54MP0009046_muscle_twitch1.31428939
55MP0000678_abnormal_parathyroid_gland1.30337374
56MP0003111_abnormal_nucleus_morphology1.29307622
57MP0003786_premature_aging1.27846437
58MP0002837_dystrophic_cardiac_calcinosis1.25395775
59MP0002282_abnormal_trachea_morphology1.22458922
60MP0002572_abnormal_emotion/affect_behav1.20300644
61MP0002653_abnormal_ependyma_morphology1.20147679
62MP0002272_abnormal_nervous_system1.20140445
63MP0005253_abnormal_eye_physiology1.18835702
64MP0000026_abnormal_inner_ear1.18784042
65MP0003880_abnormal_central_pattern1.18488286
66MP0002095_abnormal_skin_pigmentation1.15209695
67MP0002138_abnormal_hepatobiliary_system1.14799035
68MP0002557_abnormal_social/conspecific_i1.13451190
69MP0003699_abnormal_female_reproductive1.12995961
70MP0002067_abnormal_sensory_capabilities1.12538427
71MP0001502_abnormal_circadian_rhythm1.12401425
72MP0003121_genomic_imprinting1.12314563
73MP0005551_abnormal_eye_electrophysiolog1.12276148
74MP0001501_abnormal_sleep_pattern1.11306788
75MP0003879_abnormal_hair_cell1.08306495
76MP0002938_white_spotting1.08065872
77MP0003755_abnormal_palate_morphology1.07779652
78MP0003077_abnormal_cell_cycle1.05728010
79MP0002736_abnormal_nociception_after1.04980959
80MP0003646_muscle_fatigue1.04795244
81MP0001529_abnormal_vocalization1.04662055
82MP0005395_other_phenotype1.04310009
83MP0000762_abnormal_tongue_morphology1.01463081
84MP0002733_abnormal_thermal_nociception1.01396030
85MP0008057_abnormal_DNA_replication1.01286366
86MP0005645_abnormal_hypothalamus_physiol1.01125064
87MP0005389_reproductive_system_phenotype1.00752194
88MP0005084_abnormal_gallbladder_morpholo0.99001266
89MP0000955_abnormal_spinal_cord0.97180893
90MP0002161_abnormal_fertility/fecundity0.97125969
91MP0000015_abnormal_ear_pigmentation0.97105545
92MP0002229_neurodegeneration0.96629994
93MP0003937_abnormal_limbs/digits/tail_de0.96005370
94MP0006276_abnormal_autonomic_nervous0.95406984
95MP0000613_abnormal_salivary_gland0.95273734
96MP0001145_abnormal_male_reproductive0.95208398
97MP0002148_abnormal_hypersensitivity_rea0.94860022
98MP0005647_abnormal_sex_gland0.94525704
99MP0009764_decreased_sensitivity_to0.94483950
100MP0004142_abnormal_muscle_tone0.93167647
101MP0000049_abnormal_middle_ear0.92643905
102MP0008789_abnormal_olfactory_epithelium0.92562574
103MP0005670_abnormal_white_adipose0.92344241
104MP0008872_abnormal_physiological_respon0.92002035
105MP0001919_abnormal_reproductive_system0.91943211
106MP0002876_abnormal_thyroid_physiology0.90908836
107MP0004085_abnormal_heartbeat0.90885582
108MP0002060_abnormal_skin_morphology0.90760793
109MP0002177_abnormal_outer_ear0.90100021
110MP0002064_seizures0.89796247
111MP0000631_abnormal_neuroendocrine_gland0.89250125
112MP0005391_vision/eye_phenotype0.88716710
113MP0000569_abnormal_digit_pigmentation0.88039759
114MP0001984_abnormal_olfaction0.87678553
115MP0008932_abnormal_embryonic_tissue0.86904804
116MP0008260_abnormal_autophagy0.85050896
117MP0001970_abnormal_pain_threshold0.84629604
118MP0003011_delayed_dark_adaptation0.84001094
119MP0004859_abnormal_synaptic_plasticity0.83862219
120MP0001963_abnormal_hearing_physiology0.83543419
121MP0000538_abnormal_urinary_bladder0.82162328
122MP0002116_abnormal_craniofacial_bone0.80543346
123MP0006072_abnormal_retinal_apoptosis0.80417082
124MP0004742_abnormal_vestibular_system0.79948374
125MP0005508_abnormal_skeleton_morphology0.79091702
126MP0002160_abnormal_reproductive_system0.77884412
127MP0003635_abnormal_synaptic_transmissio0.77704564
128MP0000230_abnormal_systemic_arterial0.76821499
129MP0002928_abnormal_bile_duct0.76396631
130MP0002184_abnormal_innervation0.75840284
131MP0002109_abnormal_limb_morphology0.75580563
132MP0000427_abnormal_hair_cycle0.75281582
133MP0005310_abnormal_salivary_gland0.75175325
134MP0002233_abnormal_nose_morphology0.74871348
135MP0000470_abnormal_stomach_morphology0.74086670
136MP0001186_pigmentation_phenotype0.74010977
137MP0001293_anophthalmia0.73414008
138MP0005174_abnormal_tail_pigmentation0.73348194
139MP0005408_hypopigmentation0.73179955
140MP0005075_abnormal_melanosome_morpholog0.73117873
141MP0005257_abnormal_intraocular_pressure0.73107892
142MP0002734_abnormal_mechanical_nocicepti0.72258073
143MP0005167_abnormal_blood-brain_barrier0.72126347
144MP0002127_abnormal_cardiovascular_syste0.72114719
145MP0000516_abnormal_urinary_system0.69659391
146MP0005367_renal/urinary_system_phenotyp0.69659391
147MP0001765_abnormal_ion_homeostasis0.66949678
148MP0001270_distended_abdomen0.66868542
149MP0002752_abnormal_somatic_nervous0.66417029
150MP0008775_abnormal_heart_ventricle0.65710325
151MP0002063_abnormal_learning/memory/cond0.64238414
152MP0003137_abnormal_impulse_conducting0.64238301
153MP0002882_abnormal_neuron_morphology0.63593180

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.70307846
2Absent/shortened dynein arms (HP:0200106)5.25561552
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.25561552
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57589222
5Abnormal ciliary motility (HP:0012262)4.53662185
6Abnormal respiratory motile cilium physiology (HP:0012261)4.48065647
7Chromsome breakage (HP:0040012)4.41841552
8Abnormal respiratory motile cilium morphology (HP:0005938)4.17944182
9Abnormal respiratory epithelium morphology (HP:0012253)4.17944182
10Bony spicule pigmentary retinopathy (HP:0007737)3.98021780
11Abnormality of macular pigmentation (HP:0008002)3.96608844
12True hermaphroditism (HP:0010459)3.50310204
13Type II lissencephaly (HP:0007260)3.36690001
14Cone-rod dystrophy (HP:0000548)3.32720841
15Asymmetric septal hypertrophy (HP:0001670)3.30547421
16Abnormality of incisor morphology (HP:0011063)3.30542220
17Tubular atrophy (HP:0000092)3.20245587
18Nephronophthisis (HP:0000090)3.12043497
19Congenital stationary night blindness (HP:0007642)3.11934356
20Abnormal rod and cone electroretinograms (HP:0008323)3.11403235
21Rhinitis (HP:0012384)3.09447418
22Amelogenesis imperfecta (HP:0000705)3.06659826
23Pancreatic fibrosis (HP:0100732)3.01829988
24Cerebellar dysplasia (HP:0007033)2.99828249
25Hyperkalemia (HP:0002153)2.96425979
26Tubulointerstitial abnormality (HP:0001969)2.93204273
27Resting tremor (HP:0002322)2.86056973
28White forelock (HP:0002211)2.84242104
29Abnormal hair whorl (HP:0010721)2.84209387
30Pendular nystagmus (HP:0012043)2.80454492
31Abnormal drinking behavior (HP:0030082)2.79339978
32Polydipsia (HP:0001959)2.79339978
33Stage 5 chronic kidney disease (HP:0003774)2.73963235
34Abnormality of the renal medulla (HP:0100957)2.67903444
35Optic neuritis (HP:0100653)2.65181874
36Retrobulbar optic neuritis (HP:0100654)2.65181874
37Patchy hypopigmentation of hair (HP:0011365)2.64465025
38Progressive cerebellar ataxia (HP:0002073)2.63451987
39Abnormality of dental color (HP:0011073)2.59548022
40Renal cortical cysts (HP:0000803)2.53533826
41Septo-optic dysplasia (HP:0100842)2.46396311
42Abnormal pupillary function (HP:0007686)2.43714564
43Retinal dysplasia (HP:0007973)2.41805445
44Enlarged epiphyses (HP:0010580)2.39420888
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.38780051
46Nasal polyposis (HP:0100582)2.37967466
47Hypoplastic ischia (HP:0003175)2.37331210
48Lip pit (HP:0100267)2.37244356
49Abnormality of the preputium (HP:0100587)2.36109932
50Adrenal hypoplasia (HP:0000835)2.35210498
51Abnormal urine output (HP:0012590)2.34003727
52Keratoconus (HP:0000563)2.33886940
53Increased corneal curvature (HP:0100692)2.33886940
54Inability to walk (HP:0002540)2.33311929
55Medial flaring of the eyebrow (HP:0010747)2.33266328
56Abnormality of midbrain morphology (HP:0002418)2.32852275
57Molar tooth sign on MRI (HP:0002419)2.32852275
58Pancreatic cysts (HP:0001737)2.32491040
59Tubulointerstitial nephritis (HP:0001970)2.30788153
60Polyuria (HP:0000103)2.30582760
61Hypergonadotropic hypogonadism (HP:0000815)2.27631234
62Prostate neoplasm (HP:0100787)2.27135058
63Abnormality of the renal cortex (HP:0011035)2.25014403
64Aplasia/Hypoplasia of the fovea (HP:0008060)2.24813495
65Hypoplasia of the fovea (HP:0007750)2.24813495
66Postural instability (HP:0002172)2.24029969
67Abnormal spermatogenesis (HP:0008669)2.23985230
68Bell-shaped thorax (HP:0001591)2.22765739
69Generalized aminoaciduria (HP:0002909)2.22234711
70Hypoplasia of the thymus (HP:0000778)2.21410565
71Potter facies (HP:0002009)2.19837749
72Facial shape deformation (HP:0011334)2.19837749
73Nephroblastoma (Wilms tumor) (HP:0002667)2.19691834
74Ectopic kidney (HP:0000086)2.18205320
75Conical tooth (HP:0000698)2.17999710
76Sex reversal (HP:0012245)2.17678668
77Abnormal sex determination (HP:0012244)2.17678668
78Progressive sensorineural hearing impairment (HP:0000408)2.16662002
79Optic nerve hypoplasia (HP:0000609)2.15580467
80Abnormal biliary tract physiology (HP:0012439)2.14984232
81Bile duct proliferation (HP:0001408)2.14984232
82Abnormal albumin level (HP:0012116)2.14182490
83Hypoalbuminemia (HP:0003073)2.14182490
84Decreased central vision (HP:0007663)2.13412575
85Bronchiectasis (HP:0002110)2.13408822
86Abnormality of chromosome stability (HP:0003220)2.12046851
87Embryonal renal neoplasm (HP:0011794)2.11543631
88Clubbing of toes (HP:0100760)2.10229671
89Preaxial hand polydactyly (HP:0001177)2.08682141
90Postaxial foot polydactyly (HP:0001830)2.08306074
91Osteomalacia (HP:0002749)2.07901322
92Portal hypertension (HP:0001409)2.07336899
93Supernumerary spleens (HP:0009799)2.07205472
94Menstrual irregularities (HP:0000858)2.06965651
95Chronic bronchitis (HP:0004469)2.06307523
96Aplasia cutis congenita (HP:0001057)2.06030483
97Duplicated collecting system (HP:0000081)2.04386261
98Male pseudohermaphroditism (HP:0000037)2.03794349
99Abnormality of the ischium (HP:0003174)2.03668597
100Aplasia/Hypoplasia of the uvula (HP:0010293)2.03406344
101Nephrogenic diabetes insipidus (HP:0009806)2.02649936
102Alveolar cell carcinoma (HP:0006519)2.01635173
103Photophobia (HP:0000613)2.01305465
104Abnormality of the renal collecting system (HP:0004742)2.00583108
105Truncal obesity (HP:0001956)1.99954739
106Attenuation of retinal blood vessels (HP:0007843)1.99730282
107Congenital primary aphakia (HP:0007707)1.99168918
108Anencephaly (HP:0002323)1.99141476
109Cystic liver disease (HP:0006706)1.96700807
110Chronic hepatic failure (HP:0100626)1.96634635
111Intellectual disability, moderate (HP:0002342)1.95287834
112Orchitis (HP:0100796)1.95217718
113Abnormality of renal excretion (HP:0011036)1.94362866
114Congenital hepatic fibrosis (HP:0002612)1.91566163
115Congenital sensorineural hearing impairment (HP:0008527)1.90914196
116Type 2 muscle fiber atrophy (HP:0003554)1.90805201
117Gait imbalance (HP:0002141)1.90137293
118Lissencephaly (HP:0001339)1.89984779
119Meckel diverticulum (HP:0002245)1.89299373
120Abnormality of the hepatic vasculature (HP:0006707)1.88933960
121Azoospermia (HP:0000027)1.87615050
122Hypoalphalipoproteinemia (HP:0003233)1.86928759
123Abnormality of the ileum (HP:0001549)1.86130983
124Onycholysis (HP:0001806)1.85943483
125Birth length less than 3rd percentile (HP:0003561)1.85621785
126Abnormality of potassium homeostasis (HP:0011042)1.85257640
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85194778
128Horizontal nystagmus (HP:0000666)1.84248608
129Poor coordination (HP:0002370)1.83979999
130Abnormality of the fovea (HP:0000493)1.83212814
131Flat capital femoral epiphysis (HP:0003370)1.83104115
132Renal dysplasia (HP:0000110)1.83006865
133Occipital encephalocele (HP:0002085)1.82370102
134Median cleft lip (HP:0000161)1.82354295
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.82108022
136Neoplasm of the tracheobronchial system (HP:0100552)1.81378271
137Febrile seizures (HP:0002373)1.80829040
138Glycosuria (HP:0003076)1.80763805
139Abnormality of urine glucose concentration (HP:0011016)1.80763805
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80150961
141Atelectasis (HP:0100750)1.80059875
142Abnormality of DNA repair (HP:0003254)1.79591214
143Hypothermia (HP:0002045)1.78019758
144Renovascular hypertension (HP:0100817)1.77542576
145Fetal akinesia sequence (HP:0001989)1.76863097
146Abnormality of the nasal mucosa (HP:0000433)1.75816988
147Metaphyseal irregularity (HP:0003025)1.74510503
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74336981
149Absent eyebrow (HP:0002223)1.73756296
150Neonatal hypoglycemia (HP:0001998)1.73126604
151Upper limb muscle weakness (HP:0003484)1.72395768
152Sclerocornea (HP:0000647)1.71040191
153Impulsivity (HP:0100710)1.70840041
154Type II diabetes mellitus (HP:0005978)1.70392994
155Male infertility (HP:0003251)1.70368681
156Anterior segment dysgenesis (HP:0007700)1.69653873
157Absent septum pellucidum (HP:0001331)1.68999548
158Insulin-resistant diabetes mellitus (HP:0000831)1.68081980
159Infertility (HP:0000789)1.67878129
160Gastrointestinal atresia (HP:0002589)1.67148060
161Aganglionic megacolon (HP:0002251)1.66274182
162Severe visual impairment (HP:0001141)1.66205987
163Oligohydramnios (HP:0001562)1.65492805
164Abnormality of the incisor (HP:0000676)1.62204111
165Abnormality of the femoral head (HP:0003368)1.61539825
166Short middle phalanx of the 5th finger (HP:0004220)1.60885695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.75360472
2MAP4K23.25384184
3BMPR23.02395982
4PLK43.00426424
5STK38L2.76202530
6MUSK2.73357921
7PNCK2.70347773
8ZAK2.53255522
9TESK12.48064779
10ERBB32.23652964
11INSRR2.18087267
12STK382.12009255
13DDR22.08892526
14SIK32.08136111
15IRAK32.04018297
16TAOK32.00271978
17BRAF1.93245695
18AKT31.92840582
19MAP2K71.87910892
20TTK1.87884456
21STK161.82418516
22MAP3K61.80717863
23CDK31.78009865
24EIF2AK21.73077518
25MAP3K141.69045879
26TRPM71.66116571
27PBK1.65687776
28CAMK1G1.63844255
29CHEK21.63459370
30MAP3K41.62743836
31TXK1.62196339
32NUAK11.60372696
33TIE11.59703057
34MKNK21.52738776
35CDK81.50035819
36MAP3K121.46208289
37ERBB41.45477703
38LATS11.42112881
39MAPK131.40441676
40SGK21.37912064
41WNK31.35535485
42PTK2B1.30386385
43MAPK151.29014432
44BMPR1B1.26935077
45YES11.26049337
46IRAK41.22306406
47FRK1.19478724
48TRIM281.18998175
49MARK31.18614167
50MARK11.17849039
51NEK61.13996119
52PINK11.12987835
53PLK21.08883954
54STK241.07779539
55GRK11.06957781
56BRD41.06426412
57MKNK10.99421896
58PLK10.99312731
59TNIK0.96997323
60GRK70.95211121
61OXSR10.94412275
62ADRBK20.93414840
63SIK20.90055487
64STK30.88088821
65VRK10.87718767
66STK390.87692207
67WNK10.87194551
68PLK30.86441711
69CCNB10.82327800
70MOS0.80058447
71SGK4940.79410978
72SGK2230.79410978
73WNK40.76182926
74PASK0.75519616
75IRAK10.74920525
76TYRO30.69755981
77CDK70.69050468
78CHUK0.68721867
79TEC0.67505291
80IRAK20.67385713
81NLK0.67326029
82MAP2K20.67026334
83IKBKB0.66393837
84PRKCG0.65703169
85DYRK20.65603965
86PDK10.65102971
87CSNK1G20.63838977
88PRKG10.62278508
89NTRK20.61707468
90MAPKAPK50.58319761
91PDK30.58102871
92PDK40.58102871
93RPS6KA50.57611810
94PDPK10.57011009
95IKBKE0.55635655
96CSNK1G10.54820034
97CSNK1G30.54750790
98EPHA30.54348890
99PDK20.52057223
100CLK10.51490835
101PKN10.51401885
102PIK3CG0.51312517
103ACVR1B0.49827299
104CAMK10.49682328
105PRKCZ0.48969892
106MST1R0.48657563
107PRKD20.48157005
108PHKG10.47753178
109PHKG20.47753178
110JAK30.47253465
111MAP3K130.46433384
112ATM0.46236048
113TLK10.44697511
114CSNK1A1L0.44322993
115MAP2K10.42658553
116MELK0.42215910
117NEK20.41180319
118BCR0.41170202
119PRKD30.41030764
120CDK90.41023434
121LATS20.40867007
122EIF2AK30.40840468
123ATR0.40097746
124SRPK10.39897577
125MAP3K50.39756591
126FGFR20.39664907
127PRKCE0.39013505
128NTRK30.38915693
129BRSK20.38830108
130SGK30.38409522
131ROCK10.37822303
132EIF2AK10.37130322
133PAK30.36927824
134CAMK1D0.36654473
135CHEK10.35932049
136BLK0.35711834
137EPHA40.35575261
138ADRBK10.35377899
139CAMK2A0.34697324
140NME10.34219141
141AURKB0.33506247
142PRKAA20.33349553
143AKT10.32255302
144RPS6KB10.32139951
145RPS6KA10.30715332
146CDK10.30285228
147CSNK1A10.29272626
148MAPK10.28344881
149PRKACB0.27632634
150DYRK1B0.27574642
151MINK10.27068267
152GSK3B0.26740864
153PRKACA0.26713352
154BUB10.26562880

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.18497947
2Fatty acid biosynthesis_Homo sapiens_hsa000614.48454676
3Fanconi anemia pathway_Homo sapiens_hsa034603.32406659
4Butanoate metabolism_Homo sapiens_hsa006503.18826888
5Basal transcription factors_Homo sapiens_hsa030223.01680895
6Phototransduction_Homo sapiens_hsa047442.66896540
7Homologous recombination_Homo sapiens_hsa034402.36676893
8Nitrogen metabolism_Homo sapiens_hsa009102.22595517
9Non-homologous end-joining_Homo sapiens_hsa034502.19602744
10Ovarian steroidogenesis_Homo sapiens_hsa049132.09374217
11Vitamin B6 metabolism_Homo sapiens_hsa007501.95331755
12Dorso-ventral axis formation_Homo sapiens_hsa043201.92834578
13Cell cycle_Homo sapiens_hsa041101.91412526
14Selenocompound metabolism_Homo sapiens_hsa004501.87675941
15RNA degradation_Homo sapiens_hsa030181.83139878
16Linoleic acid metabolism_Homo sapiens_hsa005911.81317041
17Sphingolipid metabolism_Homo sapiens_hsa006001.80756769
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74504007
19Arachidonic acid metabolism_Homo sapiens_hsa005901.74286742
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70731882
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69897393
22Ether lipid metabolism_Homo sapiens_hsa005651.65862442
23Autoimmune thyroid disease_Homo sapiens_hsa053201.65401530
24RNA polymerase_Homo sapiens_hsa030201.63127837
25Circadian rhythm_Homo sapiens_hsa047101.60403134
26Base excision repair_Homo sapiens_hsa034101.59815749
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59377258
28Allograft rejection_Homo sapiens_hsa053301.54437376
29Graft-versus-host disease_Homo sapiens_hsa053321.51261931
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.42725897
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42009703
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36273054
33Propanoate metabolism_Homo sapiens_hsa006401.31646347
34Purine metabolism_Homo sapiens_hsa002301.27625670
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.23539399
36Taste transduction_Homo sapiens_hsa047421.23509995
37Nicotine addiction_Homo sapiens_hsa050331.23271874
38Fatty acid metabolism_Homo sapiens_hsa012121.22356099
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.21951688
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20230469
41Nucleotide excision repair_Homo sapiens_hsa034201.16773241
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14550689
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.14327521
44Huntingtons disease_Homo sapiens_hsa050161.13162462
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11965931
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07466880
47Rheumatoid arthritis_Homo sapiens_hsa053231.06838068
48Retinol metabolism_Homo sapiens_hsa008301.06568806
49Protein export_Homo sapiens_hsa030601.06353905
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05138230
51p53 signaling pathway_Homo sapiens_hsa041151.04817484
52Tryptophan metabolism_Homo sapiens_hsa003801.04661799
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04338240
54Salivary secretion_Homo sapiens_hsa049701.04047076
55Malaria_Homo sapiens_hsa051441.02948659
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02760876
57Hedgehog signaling pathway_Homo sapiens_hsa043401.02119390
58Pyrimidine metabolism_Homo sapiens_hsa002401.02098760
59GABAergic synapse_Homo sapiens_hsa047271.02030048
60Serotonergic synapse_Homo sapiens_hsa047261.01717624
61Mismatch repair_Homo sapiens_hsa034301.01097953
62ABC transporters_Homo sapiens_hsa020101.01024481
63Steroid biosynthesis_Homo sapiens_hsa001001.00904034
64Synaptic vesicle cycle_Homo sapiens_hsa047211.00749072
65Other glycan degradation_Homo sapiens_hsa005110.97017243
66Basal cell carcinoma_Homo sapiens_hsa052170.96521523
67DNA replication_Homo sapiens_hsa030300.96191715
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.95882222
69Fatty acid degradation_Homo sapiens_hsa000710.94577837
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94248589
71Circadian entrainment_Homo sapiens_hsa047130.92012736
72Hematopoietic cell lineage_Homo sapiens_hsa046400.90221249
73Cardiac muscle contraction_Homo sapiens_hsa042600.88805464
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85831206
75TNF signaling pathway_Homo sapiens_hsa046680.82847662
76TGF-beta signaling pathway_Homo sapiens_hsa043500.82366799
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82296471
78Oocyte meiosis_Homo sapiens_hsa041140.82211197
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.81811168
80Herpes simplex infection_Homo sapiens_hsa051680.79073452
81Type I diabetes mellitus_Homo sapiens_hsa049400.75334244
82Vitamin digestion and absorption_Homo sapiens_hsa049770.74215811
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73447776
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73231812
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72564622
86Chemical carcinogenesis_Homo sapiens_hsa052040.65888289
87Glycerolipid metabolism_Homo sapiens_hsa005610.65752329
88cAMP signaling pathway_Homo sapiens_hsa040240.65469567
89Oxidative phosphorylation_Homo sapiens_hsa001900.64447395
90Metabolic pathways_Homo sapiens_hsa011000.64110725
91Wnt signaling pathway_Homo sapiens_hsa043100.63437186
92Insulin secretion_Homo sapiens_hsa049110.61484795
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61325101
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60967865
95MicroRNAs in cancer_Homo sapiens_hsa052060.59533327
96Asthma_Homo sapiens_hsa053100.57164134
97Renin secretion_Homo sapiens_hsa049240.56425244
98Fat digestion and absorption_Homo sapiens_hsa049750.56340355
99Morphine addiction_Homo sapiens_hsa050320.55428771
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55330479
101Sulfur relay system_Homo sapiens_hsa041220.54380108
102Parkinsons disease_Homo sapiens_hsa050120.53722058
103Phagosome_Homo sapiens_hsa041450.52858504
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51792329
105Type II diabetes mellitus_Homo sapiens_hsa049300.51222073
106Gap junction_Homo sapiens_hsa045400.51108791
107Protein digestion and absorption_Homo sapiens_hsa049740.51103545
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51009189
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50586705
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49613410
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49603395
112Regulation of autophagy_Homo sapiens_hsa041400.48721356
113Histidine metabolism_Homo sapiens_hsa003400.48045712
114HTLV-I infection_Homo sapiens_hsa051660.47631679
115Measles_Homo sapiens_hsa051620.46675988
116Olfactory transduction_Homo sapiens_hsa047400.46495731
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.46097332
118Influenza A_Homo sapiens_hsa051640.45630018
119Primary immunodeficiency_Homo sapiens_hsa053400.44784469
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.44185853
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42422339
122Fatty acid elongation_Homo sapiens_hsa000620.42205676
123Peroxisome_Homo sapiens_hsa041460.42025494
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41566985
125Hippo signaling pathway_Homo sapiens_hsa043900.40495703
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40473781
127Melanoma_Homo sapiens_hsa052180.39866502
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39060995
129Collecting duct acid secretion_Homo sapiens_hsa049660.38486153
130Prolactin signaling pathway_Homo sapiens_hsa049170.38355092
131PPAR signaling pathway_Homo sapiens_hsa033200.38276271
132Notch signaling pathway_Homo sapiens_hsa043300.37344087
133Gastric acid secretion_Homo sapiens_hsa049710.36883782
134Ras signaling pathway_Homo sapiens_hsa040140.36651484
135Epstein-Barr virus infection_Homo sapiens_hsa051690.36572753
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.36543046
137Alcoholism_Homo sapiens_hsa050340.35500289
138Systemic lupus erythematosus_Homo sapiens_hsa053220.34219825
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33700384
140African trypanosomiasis_Homo sapiens_hsa051430.33472074
141Prostate cancer_Homo sapiens_hsa052150.33388994
142Phenylalanine metabolism_Homo sapiens_hsa003600.33117527
143Inositol phosphate metabolism_Homo sapiens_hsa005620.32727978
144One carbon pool by folate_Homo sapiens_hsa006700.30891811
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30510936
146Cholinergic synapse_Homo sapiens_hsa047250.30438204
147mRNA surveillance pathway_Homo sapiens_hsa030150.30021647
148Calcium signaling pathway_Homo sapiens_hsa040200.29705645
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29581341
150beta-Alanine metabolism_Homo sapiens_hsa004100.29575528
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29431413
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28645049
153RNA transport_Homo sapiens_hsa030130.27531938
154Glutamatergic synapse_Homo sapiens_hsa047240.27367214
155Hepatitis B_Homo sapiens_hsa051610.27135496
156Leishmaniasis_Homo sapiens_hsa051400.27083435
157Tyrosine metabolism_Homo sapiens_hsa003500.25516893

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