AKR1B10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular glucuronidation (GO:0052695)9.77899093
2glucuronate metabolic process (GO:0019585)9.24835355
3uronic acid metabolic process (GO:0006063)9.24835355
4flavonoid metabolic process (GO:0009812)8.65413060
5* glycoside metabolic process (GO:0016137)8.49667865
6progesterone metabolic process (GO:0042448)8.15138828
7* primary alcohol catabolic process (GO:0034310)7.25841005
8retinal metabolic process (GO:0042574)6.34128542
9C21-steroid hormone metabolic process (GO:0008207)6.26001486
10glucose 6-phosphate metabolic process (GO:0051156)6.08398577
11intestinal cholesterol absorption (GO:0030299)5.97423758
12pentose-phosphate shunt (GO:0006098)5.83212125
13NADPH regeneration (GO:0006740)5.72660784
14cytidine deamination (GO:0009972)5.72292574
15cytidine metabolic process (GO:0046087)5.72292574
16cytidine catabolic process (GO:0006216)5.72292574
17maintenance of protein location in nucleus (GO:0051457)5.25464793
18cysteine metabolic process (GO:0006534)5.18726307
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.05370998
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03350485
21phenylpropanoid metabolic process (GO:0009698)4.94434874
22negative regulation of cell cycle G2/M phase transition (GO:1902750)4.89947067
23glucose catabolic process (GO:0006007)4.79913053
24ethanol oxidation (GO:0006069)4.78414017
25interferon-gamma production (GO:0032609)4.78385605
26bile acid and bile salt transport (GO:0015721)4.72221001
27regulation of nuclear cell cycle DNA replication (GO:0033262)4.69215933
28intestinal absorption (GO:0050892)4.68918166
29pentose metabolic process (GO:0019321)4.66543849
30regulation of mammary gland epithelial cell proliferation (GO:0033599)4.64475457
31drug transmembrane transport (GO:0006855)4.56310530
32pyrimidine ribonucleoside catabolic process (GO:0046133)4.56101031
33regulation of response to osmotic stress (GO:0047484)4.51009370
34muscle organ morphogenesis (GO:0048644)4.38163827
35prostanoid metabolic process (GO:0006692)4.36087302
36prostaglandin metabolic process (GO:0006693)4.36087302
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34086725
38L-phenylalanine metabolic process (GO:0006558)4.34086725
39* cellular aldehyde metabolic process (GO:0006081)4.31360791
40ethanol metabolic process (GO:0006067)4.28578044
41retinoic acid metabolic process (GO:0042573)4.19754817
42protein localization to kinetochore (GO:0034501)4.18764025
43negative regulation of epidermis development (GO:0045683)4.16402987
44drug metabolic process (GO:0017144)4.11530068
45negative regulation of telomerase activity (GO:0051974)4.06266959
46* secondary metabolic process (GO:0019748)4.04728526
47negative regulation of hormone metabolic process (GO:0032351)4.04038897
48rRNA methylation (GO:0031167)4.02778391
49somite rostral/caudal axis specification (GO:0032525)4.02127585
50positive regulation of DNA-dependent DNA replication (GO:2000105)3.97967495
51positive regulation of endothelial cell apoptotic process (GO:2000353)3.87904392
52regulation of MHC class I biosynthetic process (GO:0045343)3.87138566
53rRNA transcription (GO:0009303)3.84521721
54regulation of vitamin metabolic process (GO:0030656)3.81709007
55positive regulation of protein deacetylation (GO:0090312)3.77462991
56phagocytosis, recognition (GO:0006910)3.77402130
57fat-soluble vitamin catabolic process (GO:0042363)3.76361267
58vitamin catabolic process (GO:0009111)3.76361267
59histone H4-K8 acetylation (GO:0043982)3.70888120
60histone H4-K5 acetylation (GO:0043981)3.70888120
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.69646955
62bile acid metabolic process (GO:0008206)3.68259310
63rRNA modification (GO:0000154)3.67087474
64NADP metabolic process (GO:0006739)3.62273325
65complement activation, alternative pathway (GO:0006957)3.59487126
66drug transport (GO:0015893)3.56663222
67regulation of telomere maintenance via telomerase (GO:0032210)3.54997531
68renal absorption (GO:0070293)3.54780366
69* primary alcohol metabolic process (GO:0034308)3.53751235
70regulation of cilium movement (GO:0003352)3.49555107
71response to prostaglandin (GO:0034694)3.49352098
72cofactor catabolic process (GO:0051187)3.48310433
73L-phenylalanine catabolic process (GO:0006559)3.44429407
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.44429407
75nucleoside transmembrane transport (GO:1901642)3.43978209
76negative regulation of phagocytosis (GO:0050765)3.43890166
77* retinoid metabolic process (GO:0001523)3.42945522
78* digestion (GO:0007586)3.40917385
79response to nitrosative stress (GO:0051409)3.39373862
80DNA replication checkpoint (GO:0000076)3.38472641
81* diterpenoid metabolic process (GO:0016101)3.38267761
82epoxygenase P450 pathway (GO:0019373)3.35668094
83regulation of translation in response to stress (GO:0043555)3.32644566
84negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.32326327
85immunoglobulin mediated immune response (GO:0016064)3.30958580
86* cellular ketone metabolic process (GO:0042180)3.30541756
87GDP-mannose metabolic process (GO:0019673)3.28385896
88cellular response to cadmium ion (GO:0071276)3.27811225
89negative regulation of epidermal cell differentiation (GO:0045605)3.26972857
90positive regulation of defense response to virus by host (GO:0002230)3.26690517
91positive regulation of histone deacetylation (GO:0031065)3.23698917
92glutathione biosynthetic process (GO:0006750)3.22415578
93regulation of bile acid biosynthetic process (GO:0070857)3.20906351
94primitive streak formation (GO:0090009)3.20636916
95cellular hormone metabolic process (GO:0034754)3.18805091
96urea metabolic process (GO:0019627)3.18009284
97regulation of protein activation cascade (GO:2000257)3.17544170
98pseudouridine synthesis (GO:0001522)3.17151582
99cellular response to prostaglandin stimulus (GO:0071379)3.16593229
100* terpenoid metabolic process (GO:0006721)3.15435729
101negative regulation of fatty acid metabolic process (GO:0045922)3.14079152
102histone H4-K12 acetylation (GO:0043983)3.13472572
103mitotic sister chromatid segregation (GO:0000070)3.11286549
104negative regulation of telomere maintenance (GO:0032205)3.11200071
105xenobiotic metabolic process (GO:0006805)3.08872593
106regulation of necroptotic process (GO:0060544)3.08048746
107cullin deneddylation (GO:0010388)3.07795771
108ribosomal small subunit biogenesis (GO:0042274)3.07619218
109androgen biosynthetic process (GO:0006702)3.07129507
110maintenance of protein localization in organelle (GO:0072595)3.04946396
111nucleotide-sugar biosynthetic process (GO:0009226)3.02599286
112urea cycle (GO:0000050)2.97870792
113hormone catabolic process (GO:0042447)2.97289014
114negative regulation of necroptotic process (GO:0060546)2.96998177
115nonribosomal peptide biosynthetic process (GO:0019184)2.96734133
116protein localization to chromosome, centromeric region (GO:0071459)2.96097749
117regulation of complement activation (GO:0030449)2.95345027
118ribosomal small subunit assembly (GO:0000028)2.95266522
119nucleoside transport (GO:0015858)2.94875447
120phagocytosis, engulfment (GO:0006911)2.93551869
121intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.91437236
122phenol-containing compound catabolic process (GO:0019336)2.91212877
123response to interferon-beta (GO:0035456)2.88176405
124nucleobase-containing small molecule interconversion (GO:0015949)2.87952833
125valine metabolic process (GO:0006573)2.87895701
126xenobiotic catabolic process (GO:0042178)2.87334897
127protein deneddylation (GO:0000338)2.86704541
128regulation of triglyceride catabolic process (GO:0010896)2.86341671
129cyclooxygenase pathway (GO:0019371)2.83496629
130coenzyme catabolic process (GO:0009109)2.83041630
131vitamin transmembrane transport (GO:0035461)2.82801260
132histone H4-K16 acetylation (GO:0043984)2.82646065
133B cell mediated immunity (GO:0019724)2.81952103
134arachidonic acid metabolic process (GO:0019369)2.81411794
135nitrogen cycle metabolic process (GO:0071941)2.80339895
136glutathione metabolic process (GO:0006749)2.80028618
137formation of translation preinitiation complex (GO:0001731)2.79145980
138* quinone metabolic process (GO:1901661)2.76821119
139mitochondrion distribution (GO:0048311)2.76794651
140DNA damage response, detection of DNA damage (GO:0042769)2.76603352
141macroautophagy (GO:0016236)2.76479220
142negative regulation of bone resorption (GO:0045779)2.76062131
143glutamate metabolic process (GO:0006536)2.75985854
144positive regulation of protein import into nucleus, translocation (GO:0033160)2.72572852
145negative regulation of interleukin-2 production (GO:0032703)2.71811421
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.71482036
147* isoprenoid metabolic process (GO:0006720)2.70410326
148megakaryocyte development (GO:0035855)2.69565043
149mitochondrial DNA replication (GO:0006264)2.69400280
150notochord development (GO:0030903)2.69066395
151glutathione derivative biosynthetic process (GO:1901687)2.66511673
152glutathione derivative metabolic process (GO:1901685)2.66511673
153response to dietary excess (GO:0002021)2.62552575
154fatty acid derivative transport (GO:1901571)2.62150623
155icosanoid transport (GO:0071715)2.62150623
156natural killer cell differentiation (GO:0001779)2.60470992
157response to peptidoglycan (GO:0032494)2.59701451
158regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59165242
159cardiovascular system development (GO:0072358)2.59079573
160heme transport (GO:0015886)2.59032927
161ribosome biogenesis (GO:0042254)2.58504911
162establishment of endothelial barrier (GO:0061028)2.57197328
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.56972995
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56972995
165hexose catabolic process (GO:0019320)2.56043133
166L-ascorbic acid metabolic process (GO:0019852)2.55907028
167chromatin assembly (GO:0031497)2.55210377
168regulation of telomerase activity (GO:0051972)2.54648544
169pinocytosis (GO:0006907)2.54459078
170positive regulation of chemokine biosynthetic process (GO:0045080)2.54286314
171very-low-density lipoprotein particle assembly (GO:0034379)2.53446434
172melanosome organization (GO:0032438)2.52584254
173negative regulation of gene silencing (GO:0060969)2.52126076
174biotin metabolic process (GO:0006768)2.52007095
175DNA replication-dependent nucleosome organization (GO:0034723)2.51674308
176DNA replication-dependent nucleosome assembly (GO:0006335)2.51674308
177positive regulation of lipid catabolic process (GO:0050996)2.49163410
178branching involved in mammary gland duct morphogenesis (GO:0060444)2.48863176
179pigment granule organization (GO:0048753)2.47745157
180positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47545184
181intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.46592092
182desmosome organization (GO:0002934)2.46576104
183icosanoid metabolic process (GO:0006690)2.46058467
184fatty acid derivative metabolic process (GO:1901568)2.46058467
185natural killer cell activation (GO:0030101)2.45323355
186glyoxylate metabolic process (GO:0046487)2.44820228
187response to interferon-alpha (GO:0035455)2.44634018
188regulation of cholesterol homeostasis (GO:2000188)2.44233809
189arachidonic acid secretion (GO:0050482)2.44232753
190icosanoid secretion (GO:0032309)2.44232753
191transcription from mitochondrial promoter (GO:0006390)2.43954002
192heparin metabolic process (GO:0030202)2.43576641
193cellular anion homeostasis (GO:0030002)2.40552596
194* daunorubicin metabolic process (GO:0044597)17.4303482
195* polyketide metabolic process (GO:0030638)17.4303482
196* doxorubicin metabolic process (GO:0044598)17.4303482
197* aminoglycoside antibiotic metabolic process (GO:0030647)15.2073512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.14303971
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.65069579
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.11898827
4E2F7_22180533_ChIP-Seq_HELA_Human4.79822661
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.33625252
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.12682740
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.93569577
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.69258977
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.69258977
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.69258977
11RXR_22158963_ChIP-Seq_LIVER_Mouse3.63885169
12PPARA_22158963_ChIP-Seq_LIVER_Mouse3.30735582
13STAT6_21828071_ChIP-Seq_BEAS2B_Human3.29777175
14CDX2_20551321_ChIP-Seq_CACO-2_Human3.29322505
15EGR1_23403033_ChIP-Seq_LIVER_Mouse3.20393608
16LXR_22158963_ChIP-Seq_LIVER_Mouse3.05567458
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99623536
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84723099
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.65033897
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.64301835
21GATA6_25053715_ChIP-Seq_YYC3_Human2.62762937
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.60929685
23ZNF263_19887448_ChIP-Seq_K562_Human2.57925800
24SCL_19346495_ChIP-Seq_HPC-7_Human2.50874663
25* GATA4_25053715_ChIP-Seq_YYC3_Human2.48366403
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37195746
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.34013877
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32251924
29PPAR_26484153_Chip-Seq_NCI-H1993_Human2.29826223
30AR_21909140_ChIP-Seq_LNCAP_Human2.26377517
31* SOX2_20726797_ChIP-Seq_SW620_Human2.20103004
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17298938
33RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17279684
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.16442384
35TRIM28_21343339_ChIP-Seq_HEK293_Human2.12562474
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12018990
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09461869
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.06931500
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06319757
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05505521
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.97181855
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92659927
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92659927
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90970804
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88163054
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81227781
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80057170
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78361521
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76991228
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76404904
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71645313
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.68897484
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68891603
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66998998
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.65578953
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65216512
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.64879124
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.63831227
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63824625
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63440704
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63252609
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62661940
63SPI1_23547873_ChIP-Seq_NB4_Human1.62492053
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61031665
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60811824
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59880255
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58330428
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.57015741
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55527060
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55239330
71FOXA2_19822575_ChIP-Seq_HepG2_Human1.55176755
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55040143
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54933223
74MYC_22102868_ChIP-Seq_BL_Human1.54411027
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53455434
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52957640
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46159824
78CLOCK_20551151_ChIP-Seq_293T_Human1.45463930
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.45347749
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.44390258
81RACK7_27058665_Chip-Seq_MCF-7_Human1.43325449
82FOXP3_21729870_ChIP-Seq_TREG_Human1.42928410
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42697541
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42425358
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41996703
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41439041
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40996835
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40238008
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40238008
90IRF1_19129219_ChIP-ChIP_H3396_Human1.38636172
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38544985
92ATF3_27146783_Chip-Seq_COLON_Human1.36883666
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36612878
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36311589
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33931323
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33931274
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33887701
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32823969
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30450307
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30413117
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30387931
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30269613
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30066719
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.29443924
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.28839489
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27772761
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27765969
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27158103
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22294209
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.22109977
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22046319
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21910223
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.21741820
114GATA3_24758297_ChIP-Seq_MCF-7_Human1.20955618
115GATA1_22025678_ChIP-Seq_K562_Human1.17095917
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16685831
117CIITA_25753668_ChIP-Seq_RAJI_Human1.16658475
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16230222
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15901504
120VDR_23849224_ChIP-Seq_CD4+_Human1.15412264
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14763262
122* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14366429
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14263218
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12711038
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12581605
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11194919
127* CJUN_26792858_Chip-Seq_BT549_Human1.11013863
128VDR_21846776_ChIP-Seq_THP-1_Human1.10650332
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09899183
130ETS1_20019798_ChIP-Seq_JURKAT_Human1.08498827
131MYB_26560356_Chip-Seq_TH2_Human1.08283369
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07341356
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.06574935
134* MYB_26560356_Chip-Seq_TH1_Human1.05479910
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05030927
136TCF7_22412390_ChIP-Seq_EML_Mouse1.04990393
137ESR1_20079471_ChIP-ChIP_T-47D_Human1.04280605
138KLF5_25053715_ChIP-Seq_YYC3_Human1.04043758
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.03834353
140NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03607980
141RUNX1_27514584_Chip-Seq_MCF-7_Human1.03351529
142NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03085484
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02044200
144STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01763564
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01645607
146STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00966416
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00509071
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00373686
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99959789
150MAF_26560356_Chip-Seq_TH1_Human0.99958540
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99944020
152TFEB_21752829_ChIP-Seq_HELA_Human0.98879114
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97472039
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97091185
155GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96426378
156NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95595077
157GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94503851
158IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94104890
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93494448
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92696189
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92646596
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92275462
163SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92116669
164TCF4_18268006_ChIP-ChIP_LS174T_Human0.91144819
165SPI1_23127762_ChIP-Seq_K562_Human0.90917552
166SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90522721
167ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90432126
168ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87990456
169* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87963756
170ELF5_23300383_ChIP-Seq_T47D_Human0.87681835
171TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85851643
172NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84559616
173LXR_22292898_ChIP-Seq_THP-1_Human0.84546977
174TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83936786
175EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83609806
176TET1_21451524_ChIP-Seq_MESCs_Mouse0.82994643
177FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82626130
178ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82338791
179SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81309002
180RARA_24833708_ChIP-Seq_LIVER_Mouse0.81112593
181ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79987311
182CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76195170
183NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76058953
184FOXA1_25552417_ChIP-Seq_VCAP_Human0.75982877
185ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75490743
186SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74774584
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73273425
188SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72549279
189ELK1_22589737_ChIP-Seq_MCF10A_Human0.71061250
190TP53_22127205_ChIP-Seq_IMR90_Human0.70985777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.04927116
2MP0005085_abnormal_gallbladder_physiolo5.39049925
3MP0008875_abnormal_xenobiotic_pharmacok5.30347227
4MP0005365_abnormal_bile_salt5.08416773
5MP0005360_urolithiasis4.91017661
6MP0003252_abnormal_bile_duct4.13425252
7MP0001666_abnormal_nutrient_absorption3.72692455
8MP0003806_abnormal_nucleotide_metabolis3.59212749
9MP0002254_reproductive_system_inflammat3.58333180
10MP0003011_delayed_dark_adaptation3.51810236
11MP0005075_abnormal_melanosome_morpholog2.88798827
12MP0004019_abnormal_vitamin_homeostasis2.86304517
13MP0006292_abnormal_olfactory_placode2.83169742
14MP0004264_abnormal_extraembryonic_tissu2.74141343
15MP0002396_abnormal_hematopoietic_system2.73718699
16MP0002332_abnormal_exercise_endurance2.58362557
17MP0001835_abnormal_antigen_presentation2.57524669
18MP0003868_abnormal_feces_composition2.54805499
19MP0010234_abnormal_vibrissa_follicle2.50094342
20MP0003183_abnormal_peptide_metabolism2.44528670
21MP0005332_abnormal_amino_acid2.19130071
22MP0000749_muscle_degeneration2.18614984
23MP0004858_abnormal_nervous_system2.09044987
24MP0006082_CNS_inflammation2.05784531
25MP0000343_altered_response_to2.03362419
26MP0008057_abnormal_DNA_replication2.03150941
27MP0002138_abnormal_hepatobiliary_system2.01422043
28MP0005248_abnormal_Harderian_gland1.95328731
29MP0001853_heart_inflammation1.95238921
30MP0006035_abnormal_mitochondrial_morpho1.89668889
31MP0004957_abnormal_blastocyst_morpholog1.80613659
32MP0009840_abnormal_foam_cell1.77770123
33MP0000750_abnormal_muscle_regeneration1.71022078
34MP0003828_pulmonary_edema1.70934453
35MP0000490_abnormal_crypts_of1.70453544
36MP0004084_abnormal_cardiac_muscle1.70378095
37MP0009785_altered_susceptibility_to1.66690834
38MP0008007_abnormal_cellular_replicative1.64752570
39MP0005451_abnormal_body_composition1.63292369
40MP0005394_taste/olfaction_phenotype1.62537001
41MP0005499_abnormal_olfactory_system1.62537001
42MP0003186_abnormal_redox_activity1.62466450
43MP0003436_decreased_susceptibility_to1.59606106
44MP0005671_abnormal_response_to1.59154927
45MP0003172_abnormal_lysosome_physiology1.58693093
46MP0010329_abnormal_lipoprotein_level1.56668625
47MP0000609_abnormal_liver_physiology1.54338816
48MP0002127_abnormal_cardiovascular_syste1.54152161
49MP0000685_abnormal_immune_system1.46958458
50MP0005000_abnormal_immune_tolerance1.45972574
51MP0009643_abnormal_urine_homeostasis1.44830288
52MP0006036_abnormal_mitochondrial_physio1.43231808
53MP0002132_abnormal_respiratory_system1.40502439
54MP0001800_abnormal_humoral_immune1.38744103
55MP0002148_abnormal_hypersensitivity_rea1.38132428
56MP0005257_abnormal_intraocular_pressure1.37258632
57MP0005025_abnormal_response_to1.36464562
58MP0004808_abnormal_hematopoietic_stem1.33303619
59MP0002452_abnormal_antigen_presenting1.32983182
60MP0001790_abnormal_immune_system1.31826860
61MP0005387_immune_system_phenotype1.31826860
62MP0002796_impaired_skin_barrier1.29949166
63MP0000689_abnormal_spleen_morphology1.29928206
64MP0002420_abnormal_adaptive_immunity1.29864167
65MP0010352_gastrointestinal_tract_polyps1.29040554
66MP0001819_abnormal_immune_cell1.28362083
67MP0003890_abnormal_embryonic-extraembry1.28001425
68MP0005266_abnormal_metabolism1.25957300
69MP0002118_abnormal_lipid_homeostasis1.25578278
70MP0001873_stomach_inflammation1.25355365
71MP0002398_abnormal_bone_marrow1.24985570
72MP0002722_abnormal_immune_system1.24146104
73MP0009379_abnormal_foot_pigmentation1.22698858
74MP0000678_abnormal_parathyroid_gland1.21666603
75MP0004147_increased_porphyrin_level1.20888571
76MP0002405_respiratory_system_inflammati1.20300623
77MP0003077_abnormal_cell_cycle1.19773888
78MP0003453_abnormal_keratinocyte_physiol1.18512260
79MP0003763_abnormal_thymus_physiology1.16662059
80MP0003195_calcinosis1.15510141
81MP0002723_abnormal_immune_serum1.15347282
82MP0000858_altered_metastatic_potential1.14412472
83MP0000716_abnormal_immune_system1.13777506
84MP0008961_abnormal_basal_metabolism1.11583333
85MP0005409_darkened_coat_color1.10598029
86MP0002429_abnormal_blood_cell1.10547087
87MP0001661_extended_life_span1.08847887
88MP0002419_abnormal_innate_immunity1.06710254
89MP0010630_abnormal_cardiac_muscle1.06185546
90MP0000372_irregular_coat_pigmentation1.05004746
91MP0003191_abnormal_cellular_cholesterol1.04439694
92MP0003137_abnormal_impulse_conducting1.04423127
93MP0003279_aneurysm1.04421031
94MP0002269_muscular_atrophy1.04278718
95MP0003646_muscle_fatigue1.03988973
96MP0009780_abnormal_chondrocyte_physiolo1.03943465
97MP0005584_abnormal_enzyme/coenzyme_acti1.03337568
98MP0008260_abnormal_autophagy1.02743293
99MP0001764_abnormal_homeostasis1.02614794
100MP0003122_maternal_imprinting1.02161561
101MP0004036_abnormal_muscle_relaxation1.01968250
102MP0003984_embryonic_growth_retardation0.99666117
103MP0000313_abnormal_cell_death0.99662051
104MP0002088_abnormal_embryonic_growth/wei0.99407624
105MP0000467_abnormal_esophagus_morphology0.98662836
106MP0005501_abnormal_skin_physiology0.98172107
107MP0005636_abnormal_mineral_homeostasis0.97839789
108MP0004782_abnormal_surfactant_physiolog0.97621505
109MP0002277_abnormal_respiratory_mucosa0.97363443
110MP0001664_abnormal_digestion0.97337431
111MP0002970_abnormal_white_adipose0.97265444
112MP0005380_embryogenesis_phenotype0.95160397
113MP0001672_abnormal_embryogenesis/_devel0.95160397
114MP0002136_abnormal_kidney_physiology0.94859472
115MP0004087_abnormal_muscle_fiber0.93567512
116MP0004215_abnormal_myocardial_fiber0.92909674
117MP0005330_cardiomyopathy0.90956791
118MP0010678_abnormal_skin_adnexa0.90589901
119MP0004185_abnormal_adipocyte_glucose0.89923428
120MP0010155_abnormal_intestine_physiology0.89707158
121MP0002877_abnormal_melanocyte_morpholog0.89274705
122MP0005076_abnormal_cell_differentiation0.88472488
123MP0010094_abnormal_chromosome_stability0.87212060
124MP0005408_hypopigmentation0.86732533
125MP0000350_abnormal_cell_proliferation0.86356100
126MP0005058_abnormal_lysosome_morphology0.85016435
127MP0002106_abnormal_muscle_physiology0.84740960
128MP0000462_abnormal_digestive_system0.84665063
129MP0001545_abnormal_hematopoietic_system0.83647864
130MP0005397_hematopoietic_system_phenotyp0.83647864
131MP0000703_abnormal_thymus_morphology0.83335284
132MP0005310_abnormal_salivary_gland0.83239957
133MP0002972_abnormal_cardiac_muscle0.83126688
134MP0009333_abnormal_splenocyte_physiolog0.82935335
135MP0003566_abnormal_cell_adhesion0.82832818
136MP0000598_abnormal_liver_morphology0.82463491
137MP0005319_abnormal_enzyme/_coenzyme0.81899459
138MP0001849_ear_inflammation0.81546686
139MP0008469_abnormal_protein_level0.80933726
140MP0005165_increased_susceptibility_to0.80863366
141MP0002019_abnormal_tumor_incidence0.80494067
142MP0004043_abnormal_pH_regulation0.80217833
143MP0000049_abnormal_middle_ear0.79983443
144MP0005164_abnormal_response_to0.79001647
145MP0005670_abnormal_white_adipose0.78143366
146MP0005666_abnormal_adipose_tissue0.77729050
147MP0005376_homeostasis/metabolism_phenot0.76877211
148MP0000477_abnormal_intestine_morphology0.76689212
149MP0002006_tumorigenesis0.75285846
150MP0005023_abnormal_wound_healing0.75032541
151MP0002876_abnormal_thyroid_physiology0.74999945
152MP0009115_abnormal_fat_cell0.74857845
153MP0003950_abnormal_plasma_membrane0.74355098
154MP0003656_abnormal_erythrocyte_physiolo0.73270306
155MP0009697_abnormal_copulation0.72877507
156MP0000383_abnormal_hair_follicle0.71828274
157MP0001730_embryonic_growth_arrest0.71162203
158MP0009642_abnormal_blood_homeostasis0.68763917
159MP0001216_abnormal_epidermal_layer0.66495170
160MP0001765_abnormal_ion_homeostasis0.66451856
161MP0004272_abnormal_basement_membrane0.61504004
162MP0000762_abnormal_tongue_morphology0.60789012
163MP0009765_abnormal_xenobiotic_induced0.60670428
164MP0001756_abnormal_urination0.57349584
165MP0003091_abnormal_cell_migration0.56797965
166MP0000627_abnormal_mammary_gland0.56794057
167MP0003943_abnormal_hepatobiliary_system0.55082259
168MP0002089_abnormal_postnatal_growth/wei0.54118751
169MP0003866_abnormal_defecation0.52907363
170MP0005166_decreased_susceptibility_to0.49009198
171MP0002098_abnormal_vibrissa_morphology0.48370194
172MP0008872_abnormal_physiological_respon0.46900263
173MP0006138_congestive_heart_failure0.45760248
174MP0001919_abnormal_reproductive_system0.45561907
175MP0000538_abnormal_urinary_bladder0.44346049
176MP0009764_decreased_sensitivity_to0.44131449
177MP0009053_abnormal_anal_canal0.43969614
178MP0000013_abnormal_adipose_tissue0.42636329
179MP0009763_increased_sensitivity_to0.42368153
180MP0005193_abnormal_anterior_eye0.41709484
181MP0008873_increased_physiological_sensi0.41326721
182MP0000566_synostosis0.40958834

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)8.62652062
2Sex reversal (HP:0012245)7.39562318
3Abnormal sex determination (HP:0012244)7.39562318
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44627538
5Abnormality of glutamine family amino acid metabolism (HP:0010902)6.09402758
6Abnormality of proline metabolism (HP:0010907)5.40176786
7Hydroxyprolinuria (HP:0003080)5.40176786
8Bilateral microphthalmos (HP:0007633)5.31668507
9Fat malabsorption (HP:0002630)5.09747278
10Multiple enchondromatosis (HP:0005701)5.02970729
11Hypobetalipoproteinemia (HP:0003563)4.86560453
12Steatorrhea (HP:0002570)4.66529064
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.64575900
14Complement deficiency (HP:0004431)4.47005730
15Abnormality of complement system (HP:0005339)4.16632047
16Reduced antithrombin III activity (HP:0001976)3.96043438
17Tetraparesis (HP:0002273)3.89969493
18Prolonged neonatal jaundice (HP:0006579)3.85980225
19Hyperbilirubinemia (HP:0002904)3.85763406
20Glomerulonephritis (HP:0000099)3.68471048
21Abnormality of the common coagulation pathway (HP:0010990)3.67043279
22Ragged-red muscle fibers (HP:0003200)3.66348376
23Vascular calcification (HP:0004934)3.58546519
24Hypochromic microcytic anemia (HP:0004840)3.41725512
25Type I transferrin isoform profile (HP:0003642)3.41206062
26Exercise-induced muscle cramps (HP:0003710)3.39962323
27Elevated erythrocyte sedimentation rate (HP:0003565)3.39015049
28Aplastic anemia (HP:0001915)3.27004369
29Rib fusion (HP:0000902)3.25796922
30Vertebral compression fractures (HP:0002953)3.18781042
31Rectal fistula (HP:0100590)3.16844557
32Rectovaginal fistula (HP:0000143)3.16844557
33Hepatoblastoma (HP:0002884)3.13316706
34Focal segmental glomerulosclerosis (HP:0000097)3.10919607
35Cerebral palsy (HP:0100021)3.08262013
36Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06011398
37Testicular atrophy (HP:0000029)3.05361060
38Cardiovascular calcification (HP:0011915)3.05229695
39Intrahepatic cholestasis (HP:0001406)3.03958595
40Myositis (HP:0100614)2.98245065
41Abnormality of glycolipid metabolism (HP:0010969)2.96459824
42Abnormality of liposaccharide metabolism (HP:0010968)2.96459824
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.96459824
44Systemic lupus erythematosus (HP:0002725)2.94802067
45Vaginal fistula (HP:0004320)2.94585635
46Hypolipoproteinemia (HP:0010981)2.94366050
47Abnormality of the Achilles tendon (HP:0005109)2.93806383
48Hypoplasia of the fovea (HP:0007750)2.93596558
49Aplasia/Hypoplasia of the fovea (HP:0008060)2.93596558
50Nephroblastoma (Wilms tumor) (HP:0002667)2.89849925
51Ependymoma (HP:0002888)2.87601749
52Hepatocellular carcinoma (HP:0001402)2.86160793
53Intestinal fistula (HP:0100819)2.85598822
54Nephritis (HP:0000123)2.80227931
55Nasal polyposis (HP:0100582)2.78597124
56Rhabdomyosarcoma (HP:0002859)2.75768319
57Abnormality of vitamin metabolism (HP:0100508)2.74774969
58Deep venous thrombosis (HP:0002625)2.73738759
59Xanthomatosis (HP:0000991)2.73120962
60Chromsome breakage (HP:0040012)2.72496840
61Prolonged partial thromboplastin time (HP:0003645)2.71842597
62Spontaneous abortion (HP:0005268)2.70953188
63Orchitis (HP:0100796)2.68817055
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67970046
65Embryonal renal neoplasm (HP:0011794)2.67156066
66Abnormality of the nasal mucosa (HP:0000433)2.65155457
67Neoplasm of striated muscle (HP:0009728)2.64618933
68Glomerulosclerosis (HP:0000096)2.62774674
69Proximal tubulopathy (HP:0000114)2.62714232
70Partial duplication of thumb phalanx (HP:0009944)2.62625567
71Hyperinsulinemic hypoglycemia (HP:0000825)2.60015466
72Malnutrition (HP:0004395)2.58347018
73Generalized aminoaciduria (HP:0002909)2.55579906
74Rickets (HP:0002748)2.49816130
75Hyponatremia (HP:0002902)2.47307832
76Hemorrhage of the eye (HP:0011885)2.47082214
77Difficulty running (HP:0009046)2.45566791
78Glycosuria (HP:0003076)2.43988410
79Abnormality of urine glucose concentration (HP:0011016)2.43988410
80Abnormality of the gastric mucosa (HP:0004295)2.43514072
81Hyperammonemia (HP:0001987)2.43173810
82Ventricular tachycardia (HP:0004756)2.40864808
83Broad face (HP:0000283)2.40213162
84Microvesicular hepatic steatosis (HP:0001414)2.39801118
85Abnormality of pyrimidine metabolism (HP:0004353)2.37581781
86Abnormality of the fovea (HP:0000493)2.37124172
87Abnormal lung lobation (HP:0002101)2.36967745
88Trismus (HP:0000211)2.36001745
89Abnormality of the nasal septum (HP:0000419)2.34533094
90Paraparesis (HP:0002385)2.33880883
91Increased connective tissue (HP:0009025)2.33561213
92Progressive muscle weakness (HP:0003323)2.32125551
93Nausea (HP:0002018)2.31582654
94Hypercholesterolemia (HP:0003124)2.29284078
95Cheilitis (HP:0100825)2.25260271
96Oral leukoplakia (HP:0002745)2.21798018
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21626120
98Abnormal protein N-linked glycosylation (HP:0012347)2.21626120
99Abnormal protein glycosylation (HP:0012346)2.21626120
100Abnormal glycosylation (HP:0012345)2.21626120
1013-Methylglutaconic aciduria (HP:0003535)2.21607342
102Recurrent abscess formation (HP:0002722)2.18814084
103Mitral stenosis (HP:0001718)2.18472672
104Bifid tongue (HP:0010297)2.18260565
105Reticulocytosis (HP:0001923)2.15848922
106Myoglobinuria (HP:0002913)2.15587700
107Short nail (HP:0001799)2.15315762
108Flat acetabular roof (HP:0003180)2.14806191
109Petechiae (HP:0000967)2.14773472
110Abnormality of the salivary glands (HP:0010286)2.14593630
111Partial duplication of the phalanx of hand (HP:0009999)2.13956076
112Micronodular cirrhosis (HP:0001413)2.12961536
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11688338
114Microretrognathia (HP:0000308)2.10474823
115Short middle phalanx of the 5th finger (HP:0004220)2.09124520
116Osteolytic defects of the hand bones (HP:0009699)2.08436950
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.08436950
118Vacuolated lymphocytes (HP:0001922)2.06949092
119Horizontal nystagmus (HP:0000666)2.04389986
120Elevated alkaline phosphatase (HP:0003155)2.03963332
121Subacute progressive viral hepatitis (HP:0006572)2.03443484
122Gout (HP:0001997)2.01237730
123Abnormality of alkaline phosphatase activity (HP:0004379)2.00479819
124Renal tubular acidosis (HP:0001947)2.00110246
125Abnormal cartilage morphology (HP:0002763)1.99638096
126Increased serum ferritin (HP:0003281)1.98762787
127Preauricular skin tag (HP:0000384)1.97564622
128Abnormality of iron homeostasis (HP:0011031)1.95143255
129Achilles tendon contracture (HP:0001771)1.94584080
130Abnormal enzyme/coenzyme activity (HP:0012379)1.94253673
131Fused cervical vertebrae (HP:0002949)1.94005730
132Abdominal distention (HP:0003270)1.93324713
133Preauricular pit (HP:0004467)1.93004272
134Periauricular skin pits (HP:0100277)1.93004272
135Nasolacrimal duct obstruction (HP:0000579)1.91693941
136Combined immunodeficiency (HP:0005387)1.91025684
137Myelodysplasia (HP:0002863)1.90199253
138Hypochromic anemia (HP:0001931)1.88391241
139Meckel diverticulum (HP:0002245)1.86022224
140Back pain (HP:0003418)1.85670758
141Late onset (HP:0003584)1.84951605
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84198717
143Selective tooth agenesis (HP:0001592)1.84046123
144Amyloidosis (HP:0011034)1.83909641
145IgM deficiency (HP:0002850)1.83715505
146Abnormal urine phosphate concentration (HP:0012599)1.82931988
147Cone-rod dystrophy (HP:0000548)1.82331441
148Hyperphosphaturia (HP:0003109)1.82205942
149Abnormality of the left ventricular outflow tract (HP:0011103)1.81705687
150Subaortic stenosis (HP:0001682)1.81705687
151Hypokinesia (HP:0002375)1.81337415
152Short 5th finger (HP:0009237)1.81196458
153Tongue fasciculations (HP:0001308)1.80807186
154Thrombocytosis (HP:0001894)1.80402753
155Adrenal hypoplasia (HP:0000835)1.79413814
156Abnormality of sodium homeostasis (HP:0010931)1.79073372
157Abnormality of T cell physiology (HP:0011840)1.78830588
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.78362560
159Renal tubular dysfunction (HP:0000124)1.78297156
160Neonatal death (HP:0003811)1.76948972
161Rough bone trabeculation (HP:0100670)1.76667634
162Abnormality of transition element cation homeostasis (HP:0011030)1.75681669
163Abnormality of nucleobase metabolism (HP:0010932)1.75324853
164Coarse hair (HP:0002208)1.74798962
165Chest pain (HP:0100749)1.74154937
166Sparse eyelashes (HP:0000653)1.74063601
167Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73386613
168Ileus (HP:0002595)1.72131027
169Aplasia/hypoplasia of the humerus (HP:0006507)1.71685644
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.71372308
171Elfin facies (HP:0004428)1.71307685
172Skin tags (HP:0010609)1.71263950
173Cellulitis (HP:0100658)1.70424293
174Abnormal trabecular bone morphology (HP:0100671)1.70289775
175Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.69987801
176Muscle fibrillation (HP:0010546)1.69729095
177Poor head control (HP:0002421)1.69383617
178Abnormality of the ileum (HP:0001549)1.68133494
179Abnormality of the pleura (HP:0002103)1.68071790
180Abnormality of glycolysis (HP:0004366)1.67640042
181Increased serum pyruvate (HP:0003542)1.67640042
182Bone pain (HP:0002653)1.67548179
183Hyperuricemia (HP:0002149)1.66703624
184Increased purine levels (HP:0004368)1.66703624
185Right ventricular cardiomyopathy (HP:0011663)1.66475634
186Abnormality of the lower motor neuron (HP:0002366)1.66188073
187Short humerus (HP:0005792)1.66056853
188Medulloblastoma (HP:0002885)1.65948729
189Generalized amyotrophy (HP:0003700)1.65763158
190Recurrent viral infections (HP:0004429)1.64210896
191Megaloblastic anemia (HP:0001889)1.63984246
192Exocrine pancreatic insufficiency (HP:0001738)1.63615326
193Exercise-induced myalgia (HP:0003738)1.63239110
194Abnormal glucose tolerance (HP:0001952)1.63040314
195Abnormality of chromosome segregation (HP:0002916)1.62257920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.52932305
2CDK125.59896959
3ERN15.01960402
4MET4.20379698
5GRK53.61985749
6ERBB43.50338655
7TGFBR23.44651396
8GRK63.39623855
9CSF1R3.38303446
10ADRBK22.74383959
11MATK2.49933278
12GRK72.43115131
13KIT2.39502286
14GRK12.25364428
15STK102.07942916
16DDR22.04232987
17FLT32.02315947
18TESK12.00670798
19PRKG21.84828363
20MAPK71.68665835
21MAP2K31.65470330
22PBK1.63265597
23MOS1.59780385
24MUSK1.57873787
25EIF2AK11.56767317
26TTK1.50983156
27FGFR41.42006193
28SIK11.39701564
29MAP3K121.37406058
30BCKDK1.37086363
31CDK71.35841844
32PDGFRA1.33232418
33MYLK1.29888682
34PIK3CG1.29392410
35PAK41.27083049
36BMX1.24793592
37TLK11.23904604
38NME21.22283963
39MAPK111.20040021
40IRAK41.19960256
41ICK1.17983375
42TYK21.13547608
43MELK1.12545133
44MAP4K11.12413729
45MAP2K61.09894906
46CAMK41.09622329
47IRAK21.08971065
48TTN1.05657796
49BTK1.04235539
50PIM21.01673609
51LIMK11.01644279
52LMTK20.97480799
53TEC0.95869828
54CDC42BPA0.95604928
55CDK80.95040372
56IKBKB0.94477730
57MAPKAPK30.94211022
58BLK0.93307337
59TBK10.93181927
60CDK90.92210250
61JAK30.91546741
62MAP3K70.90934132
63MAP3K20.90560852
64BRSK10.88820501
65ZAP700.88628494
66OBSCN0.88085143
67HIPK20.86923375
68MAPK120.86533070
69PTK20.85475160
70IRAK10.84382428
71MAP3K100.82497220
72PRKCI0.81340708
73ADRBK10.81043461
74ARAF0.79900044
75IRAK30.79831325
76RPS6KB20.77673694
77EIF2AK20.77163963
78FGFR30.76952636
79MAP3K140.69665040
80WNK10.69009402
81CAMK2G0.68354730
82PDK20.67580796
83TRIB30.65515616
84TXK0.62430331
85SYK0.62331544
86PRPF4B0.60736160
87NTRK10.60294486
88ITK0.58029935
89TGFBR10.57705200
90EIF2AK30.56307501
91CHEK20.56018475
92IGF1R0.55126827
93AKT20.54464713
94SMG10.53892909
95BUB10.53319249
96CSK0.53208149
97MST40.52953492
98LYN0.52159130
99STK390.51449316
100PLK10.50866676
101MAP2K70.50601076
102VRK10.50276286
103LCK0.49905321
104WEE10.49854230
105MAP3K80.48698825
106HCK0.48541959
107SCYL20.48366295
108MAP3K90.48337185
109STK40.47531214
110CHUK0.47159889
111PHKG10.46123728
112TYRO30.45937834
113LRRK20.45373280
114TRPM70.45262873
115PTK60.44492950
116FGR0.44098381
117AURKA0.42815352
118NEK10.42709825
119PRKCD0.42709402
120ABL20.42668297
121PKN20.42285610
122EPHA20.42257096
123LATS20.42096023
124MAP2K20.41745051
125DAPK10.41625381
126CDK40.41484265
127CAMK2B0.40915950
128BRSK20.40822326
129PRKAA20.40418768
130PIK3CA0.40203386
131IKBKE0.39459503
132MARK20.38808283
133CAMK2D0.38633183
134PRKCE0.38505175
135TNK20.37300624
136MAP2K40.36776342
137PDK30.36335311
138PDK40.36335311
139RIPK10.36133645
140ZAK0.35222579
141PDPK10.35067786
142PIM10.34590854
143EPHB20.34483986
144TAOK20.34412485
145EPHA30.33849717
146ACVR1B0.32964469
147MAP3K10.32769539
148MAPKAPK20.31177890
149STK380.30710671
150MAPK40.30040483
151RIPK40.29923270
152CAMK10.29486428
153CASK0.29263529
154MAP3K30.28873673
155NME10.26558099
156AURKB0.26532272
157PHKG20.26207436
158SRC0.24718129
159BRAF0.24547009
160FER0.20770254
161ILK0.20661524
162NEK90.19787520
163EPHB10.18131171
164PRKCZ0.14931956
165MAP2K10.14145424

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.86147130
2* Pentose and glucuronate interconversions_Homo sapiens_hsa000404.88163612
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.39565393
4Steroid hormone biosynthesis_Homo sapiens_hsa001404.05040332
5Drug metabolism - other enzymes_Homo sapiens_hsa009833.50798270
6Chemical carcinogenesis_Homo sapiens_hsa052043.24801903
7Starch and sucrose metabolism_Homo sapiens_hsa005003.17452306
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.12053420
9Retinol metabolism_Homo sapiens_hsa008303.07354601
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.01058332
11Other glycan degradation_Homo sapiens_hsa005112.81322163
12DNA replication_Homo sapiens_hsa030302.71670640
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.62619960
14Vitamin B6 metabolism_Homo sapiens_hsa007502.53551285
15Ribosome_Homo sapiens_hsa030102.52621827
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49000308
17Mismatch repair_Homo sapiens_hsa034302.22497397
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21785801
19Glutathione metabolism_Homo sapiens_hsa004802.19323527
20Glycosaminoglycan degradation_Homo sapiens_hsa005312.16829467
21Histidine metabolism_Homo sapiens_hsa003402.12942561
22Cyanoamino acid metabolism_Homo sapiens_hsa004602.11331606
23Arachidonic acid metabolism_Homo sapiens_hsa005902.09067207
24* Fructose and mannose metabolism_Homo sapiens_hsa000512.06675021
25Phenylalanine metabolism_Homo sapiens_hsa003601.98801583
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88884221
27Fat digestion and absorption_Homo sapiens_hsa049751.78248836
28* Galactose metabolism_Homo sapiens_hsa000521.73856827
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69444903
30Bile secretion_Homo sapiens_hsa049761.67661959
31Leishmaniasis_Homo sapiens_hsa051401.65499385
32Vitamin digestion and absorption_Homo sapiens_hsa049771.63307083
33Homologous recombination_Homo sapiens_hsa034401.52028864
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51975439
35Tyrosine metabolism_Homo sapiens_hsa003501.48474621
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47849384
37Base excision repair_Homo sapiens_hsa034101.46308693
38Primary immunodeficiency_Homo sapiens_hsa053401.44386635
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43755753
40Complement and coagulation cascades_Homo sapiens_hsa046101.41534011
41Sulfur metabolism_Homo sapiens_hsa009201.38064151
42Legionellosis_Homo sapiens_hsa051341.37479754
43Herpes simplex infection_Homo sapiens_hsa051681.35752759
44Arginine biosynthesis_Homo sapiens_hsa002201.26864245
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.24826720
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22843356
47ABC transporters_Homo sapiens_hsa020101.20857845
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20025519
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.19642028
50B cell receptor signaling pathway_Homo sapiens_hsa046621.19375208
51Antigen processing and presentation_Homo sapiens_hsa046121.18142822
52Pentose phosphate pathway_Homo sapiens_hsa000301.16797925
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.16670099
54RNA degradation_Homo sapiens_hsa030181.14695750
55Measles_Homo sapiens_hsa051621.13228378
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11092487
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.11011772
58Acute myeloid leukemia_Homo sapiens_hsa052211.10333794
59Caffeine metabolism_Homo sapiens_hsa002321.10044271
60Hematopoietic cell lineage_Homo sapiens_hsa046401.09444263
61Carbon metabolism_Homo sapiens_hsa012001.08802488
62beta-Alanine metabolism_Homo sapiens_hsa004101.07607134
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05290584
64Fanconi anemia pathway_Homo sapiens_hsa034601.04772657
65Non-homologous end-joining_Homo sapiens_hsa034500.98033354
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96634807
67Lysosome_Homo sapiens_hsa041420.95379510
68Thyroid cancer_Homo sapiens_hsa052160.95193694
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94011632
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.93998082
71Tryptophan metabolism_Homo sapiens_hsa003800.93863341
72p53 signaling pathway_Homo sapiens_hsa041150.93080447
73Influenza A_Homo sapiens_hsa051640.92359797
74Arginine and proline metabolism_Homo sapiens_hsa003300.92061956
75Renin-angiotensin system_Homo sapiens_hsa046140.91998717
76Apoptosis_Homo sapiens_hsa042100.91264740
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.90182680
78Pyruvate metabolism_Homo sapiens_hsa006200.89632334
79Biosynthesis of amino acids_Homo sapiens_hsa012300.89579878
80Nucleotide excision repair_Homo sapiens_hsa034200.87827998
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.87511401
82Protein digestion and absorption_Homo sapiens_hsa049740.86835631
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86533238
84Malaria_Homo sapiens_hsa051440.83291489
85Pancreatic secretion_Homo sapiens_hsa049720.83260810
86Cell cycle_Homo sapiens_hsa041100.81693742
87PPAR signaling pathway_Homo sapiens_hsa033200.80169637
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80100715
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80017252
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79223091
91* Glycerolipid metabolism_Homo sapiens_hsa005610.79177050
92Selenocompound metabolism_Homo sapiens_hsa004500.78885555
93Pyrimidine metabolism_Homo sapiens_hsa002400.78311884
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77998717
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77138096
96Spliceosome_Homo sapiens_hsa030400.76802632
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76390410
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76153565
99Parkinsons disease_Homo sapiens_hsa050120.75428051
100Toxoplasmosis_Homo sapiens_hsa051450.73687393
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73556148
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72434499
103RNA transport_Homo sapiens_hsa030130.68275921
104Proteasome_Homo sapiens_hsa030500.68180942
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68132369
106Fatty acid degradation_Homo sapiens_hsa000710.68085103
107Osteoclast differentiation_Homo sapiens_hsa043800.67056288
108Tuberculosis_Homo sapiens_hsa051520.66780376
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.65520965
110Mineral absorption_Homo sapiens_hsa049780.65191562
111RNA polymerase_Homo sapiens_hsa030200.64288132
112Cardiac muscle contraction_Homo sapiens_hsa042600.64227842
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63603601
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63127103
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62566964
116Oxidative phosphorylation_Homo sapiens_hsa001900.62230386
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60025552
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59502158
119Linoleic acid metabolism_Homo sapiens_hsa005910.57273474
120Platelet activation_Homo sapiens_hsa046110.56862823
121Pertussis_Homo sapiens_hsa051330.55265580
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54974358
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.54651980
124Peroxisome_Homo sapiens_hsa041460.54276745
125African trypanosomiasis_Homo sapiens_hsa051430.54236113
126Graft-versus-host disease_Homo sapiens_hsa053320.53827743
127Dilated cardiomyopathy_Homo sapiens_hsa054140.52220852
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50149613
129Folate biosynthesis_Homo sapiens_hsa007900.48537751
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48264037
131HIF-1 signaling pathway_Homo sapiens_hsa040660.47569407
132Allograft rejection_Homo sapiens_hsa053300.46114532
133Sulfur relay system_Homo sapiens_hsa041220.45998592
134Viral myocarditis_Homo sapiens_hsa054160.45279438
135HTLV-I infection_Homo sapiens_hsa051660.44880437
136* Metabolic pathways_Homo sapiens_hsa011000.44758209
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44571428
138Fatty acid metabolism_Homo sapiens_hsa012120.43878210
139Insulin resistance_Homo sapiens_hsa049310.43645073
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43562218
141Basal transcription factors_Homo sapiens_hsa030220.42990145
142One carbon pool by folate_Homo sapiens_hsa006700.42014783
143Small cell lung cancer_Homo sapiens_hsa052220.41880397
144Huntingtons disease_Homo sapiens_hsa050160.41198819
145Pathways in cancer_Homo sapiens_hsa052000.40966611
146mTOR signaling pathway_Homo sapiens_hsa041500.40302442
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40222476
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38560728
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37477673
150Hepatitis B_Homo sapiens_hsa051610.37041195
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35802269
152Purine metabolism_Homo sapiens_hsa002300.34736666
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34518377
154Ovarian steroidogenesis_Homo sapiens_hsa049130.30329434
155Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29740189
156Fatty acid biosynthesis_Homo sapiens_hsa000610.27908932
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26022077
158N-Glycan biosynthesis_Homo sapiens_hsa005100.21761828
159Steroid biosynthesis_Homo sapiens_hsa001000.19779364
160Thyroid hormone synthesis_Homo sapiens_hsa049180.18057503
161Staphylococcus aureus infection_Homo sapiens_hsa051500.17273352
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16128585
163Butanoate metabolism_Homo sapiens_hsa006500.15906672
164Sphingolipid metabolism_Homo sapiens_hsa006000.15428588
165Prion diseases_Homo sapiens_hsa050200.15231529
166Nitrogen metabolism_Homo sapiens_hsa009100.12478081
167Lysine degradation_Homo sapiens_hsa003100.06597377
168Adherens junction_Homo sapiens_hsa045200.04860136
169Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1014122
170Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0991731
171Hepatitis C_Homo sapiens_hsa05160-0.0848555
172Tight junction_Homo sapiens_hsa04530-0.0358510
173Ether lipid metabolism_Homo sapiens_hsa00565-0.0336363
174Vibrio cholerae infection_Homo sapiens_hsa05110-0.0304602
175Propanoate metabolism_Homo sapiens_hsa00640-0.0111560

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