ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone mRNA catabolic process (GO:0071044)	8.46949159
2	snRNA processing (GO:0016180)	8.05591316
3	mRNA cleavage (GO:0006379)	7.34649560
4	snRNA metabolic process (GO:0016073)	7.23233649
5	L-fucose catabolic process (GO:0042355)	6.71210105
6	fucose catabolic process (GO:0019317)	6.71210105
7	L-fucose metabolic process (GO:0042354)	6.71210105
8	behavioral response to nicotine (GO:0035095)	6.27987131
9	protein prenylation (GO:0018342)	6.01129463
10	prenylation (GO:0097354)	6.01129463
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.68567411
12	ATP synthesis coupled proton transport (GO:0015986)	5.68567411
13	fat-soluble vitamin catabolic process (GO:0042363)	4.65926921
14	vitamin catabolic process (GO:0009111)	4.65926921
15	mRNA polyadenylation (GO:0006378)	4.62426033
16	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.56659634
17	RNA polyadenylation (GO:0043631)	4.37785362
18	pseudouridine synthesis (GO:0001522)	4.37429026
19	coenzyme catabolic process (GO:0009109)	4.33415117
20	cellular ketone body metabolic process (GO:0046950)	4.28025038
21	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.23491513
22	protein K11-linked deubiquitination (GO:0035871)	4.18343398
23	maturation of 5.8S rRNA (GO:0000460)	4.14741173
24	kynurenine metabolic process (GO:0070189)	4.02512036
25	histone mRNA metabolic process (GO:0008334)	3.86023418
26	protein-cofactor linkage (GO:0018065)	3.81428137
27	ketone body metabolic process (GO:1902224)	3.76313421
28	vitamin transmembrane transport (GO:0035461)	3.74853340
29	fucosylation (GO:0036065)	3.70508455
30	negative regulation of telomere maintenance (GO:0032205)	3.65897856
31	iron ion import (GO:0097286)	3.65169332
32	ATP biosynthetic process (GO:0006754)	3.64527745
33	multicellular organism reproduction (GO:0032504)	3.57239984
34	protein import into peroxisome matrix (GO:0016558)	3.54514984
35	regulation of hippo signaling (GO:0035330)	3.51579148
36	indole-containing compound catabolic process (GO:0042436)	3.49890996
37	indolalkylamine catabolic process (GO:0046218)	3.49890996
38	tryptophan catabolic process (GO:0006569)	3.49890996
39	basic amino acid transport (GO:0015802)	3.44812233
40	indolalkylamine metabolic process (GO:0006586)	3.36380530
41	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.34073606
42	response to pheromone (GO:0019236)	3.29743586
43	auditory receptor cell stereocilium organization (GO:0060088)	3.24268007
44	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.24036486
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.20151451
46	N-acetylglucosamine metabolic process (GO:0006044)	3.17637185
47	detection of light stimulus involved in sensory perception (GO:0050962)	3.14951749
48	detection of light stimulus involved in visual perception (GO:0050908)	3.14951749
49	exogenous drug catabolic process (GO:0042738)	3.12858070
50	fucose metabolic process (GO:0006004)	3.08340946
51	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.08011564
52	adaptation of signaling pathway (GO:0023058)	3.06040559
53	peptidyl-histidine modification (GO:0018202)	3.05765538
54	regulation of neurotransmitter uptake (GO:0051580)	3.04492538
55	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.03356443
56	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.01491321
57	behavioral response to ethanol (GO:0048149)	3.01056434
58	N-acetylneuraminate metabolic process (GO:0006054)	3.00224394
59	regulation of sarcomere organization (GO:0060297)	2.92739094
60	lysine metabolic process (GO:0006553)	2.91634197
61	lysine catabolic process (GO:0006554)	2.91634197
62	regulation of posttranscriptional gene silencing (GO:0060147)	2.90729040
63	regulation of gene silencing by miRNA (GO:0060964)	2.90729040
64	regulation of gene silencing by RNA (GO:0060966)	2.90729040
65	tryptophan metabolic process (GO:0006568)	2.87104301
66	piRNA metabolic process (GO:0034587)	2.85778960
67	reflex (GO:0060004)	2.84695188
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.83711333
69	negative regulation of mast cell activation (GO:0033004)	2.83477891
70	DNA integration (GO:0015074)	2.83085104
71	kidney morphogenesis (GO:0060993)	2.80476828
72	regulation of action potential (GO:0098900)	2.80244750
73	drug catabolic process (GO:0042737)	2.79603484
74	nephron tubule morphogenesis (GO:0072078)	2.79511015
75	nephron epithelium morphogenesis (GO:0072088)	2.79511015
76	tRNA modification (GO:0006400)	2.78873347
77	cellular response to ATP (GO:0071318)	2.78825445
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.77906273
79	auditory behavior (GO:0031223)	2.77368117
80	endosome to pigment granule transport (GO:0043485)	2.76484520
81	endosome to melanosome transport (GO:0035646)	2.76484520
82	plasma membrane repair (GO:0001778)	2.74586470
83	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.74566384
84	head development (GO:0060322)	2.74256812
85	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.73725647
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.73693644
87	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.73693644
88	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.71151282
89	platelet dense granule organization (GO:0060155)	2.69147480
90	inner ear receptor cell development (GO:0060119)	2.67268543
91	indole-containing compound metabolic process (GO:0042430)	2.66546821
92	regulation of T cell mediated cytotoxicity (GO:0001914)	2.66466132
93	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64716867
94	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.63875434
95	membrane depolarization during action potential (GO:0086010)	2.63616691
96	arginine catabolic process (GO:0006527)	2.61355337
97	positive regulation of CREB transcription factor activity (GO:0032793)	2.59976726
98	inner ear receptor stereocilium organization (GO:0060122)	2.59890384
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59352223
100	polyol catabolic process (GO:0046174)	2.59321447

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	6.05896577
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.76372966
3	VDR_22108803_ChIP-Seq_LS180_Human	4.39273154
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61068148
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.45387080
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.29439948
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26622211
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01421731
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98495070
10	AR_21572438_ChIP-Seq_LNCaP_Human	1.96858520
11	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85981463
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83386336
13	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.79188744
14	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.77559296
15	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.75057934
16	EWS_26573619_Chip-Seq_HEK293_Human	1.73816277
17	FUS_26573619_Chip-Seq_HEK293_Human	1.71952667
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71234779
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.70226681
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70046395
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.67503269
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66160120
23	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.65829616
24	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.65829616
25	STAT3_23295773_ChIP-Seq_U87_Human	1.64823503
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.61680135
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58161765
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55743703
29	P300_19829295_ChIP-Seq_ESCs_Human	1.55019605
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.54237653
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52991433
32	AR_20517297_ChIP-Seq_VCAP_Human	1.50133641
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48423675
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48393864
35	TCF4_23295773_ChIP-Seq_U87_Human	1.47748286
36	AR_25329375_ChIP-Seq_VCAP_Human	1.43311287
37	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42964983
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39903186
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.38914061
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.38048553
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35038961
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33768494
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33768494
44	NCOR_22424771_ChIP-Seq_293T_Human	1.32959482
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32595075
46	HOXB7_26014856_ChIP-Seq_BT474_Human	1.32474035
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30957501
48	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.30834787
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30799101
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28974781
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27737741
52	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26976868
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26468394
54	P53_21459846_ChIP-Seq_SAOS-2_Human	1.25252007
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24432956
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24032764
57	ERA_21632823_ChIP-Seq_H3396_Human	1.23768440
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23219780
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20019225
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18968554
61	GATA3_26560356_Chip-Seq_TH2_Human	1.16650780
62	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.16370754
63	EZH2_22144423_ChIP-Seq_EOC_Human	1.15520639
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.15031358
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.14901696
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14265667
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14265667
68	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12746772
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12731378
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10917552
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09523713
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09485223
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08961995
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.08961995
75	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.08867063
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.08817428
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07232522
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.05470969
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04935706
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04751012
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.04001433
82	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.03730360
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02554052
84	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02262751
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99556627
86	TP53_16413492_ChIP-PET_HCT116_Human	0.99470435
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.99401314
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97420747
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97362021
90	PHF8_20622853_ChIP-Seq_HELA_Human	0.96766737
91	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95622741
92	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94722662
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92983835
94	GATA1_22025678_ChIP-Seq_K562_Human	0.92764672
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92035613
96	DROSHA_22980978_ChIP-Seq_HELA_Human	0.88470278
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88067020
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.86553286
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.85795755
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.85617260

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004043_abnormal_pH_regulation	4.70549993
2	MP0003646_muscle_fatigue	3.84218092
3	MP0004147_increased_porphyrin_level	3.52382017
4	MP0003195_calcinosis	3.33046150
5	MP0002102_abnormal_ear_morphology	2.94992454
6	MP0001986_abnormal_taste_sensitivity	2.80704091
7	MP0005167_abnormal_blood-brain_barrier	2.47010196
8	MP0000569_abnormal_digit_pigmentation	2.44757575
9	MP0002638_abnormal_pupillary_reflex	2.40295921
10	MP0009745_abnormal_behavioral_response	2.38959896
11	MP0005551_abnormal_eye_electrophysiolog	2.33476606
12	MP0005645_abnormal_hypothalamus_physiol	2.33346391
13	MP0008875_abnormal_xenobiotic_pharmacok	2.33321272
14	MP0008872_abnormal_physiological_respon	2.31675066
15	MP0003693_abnormal_embryo_hatching	2.31386796
16	MP0001485_abnormal_pinna_reflex	2.18190538
17	MP0000427_abnormal_hair_cycle	2.10543027
18	MP0001501_abnormal_sleep_pattern	2.08251028
19	MP0002876_abnormal_thyroid_physiology	1.89205329
20	MP0001968_abnormal_touch/_nociception	1.79920879
21	MP0002837_dystrophic_cardiac_calcinosis	1.79477824
22	MP0002653_abnormal_ependyma_morphology	1.78334812
23	MP0003718_maternal_effect	1.71432444
24	MP0009046_muscle_twitch	1.69054740
25	MP0008877_abnormal_DNA_methylation	1.68916771
26	MP0008775_abnormal_heart_ventricle	1.68130901
27	MP0005253_abnormal_eye_physiology	1.60446086
28	MP0000383_abnormal_hair_follicle	1.53247901
29	MP0000372_irregular_coat_pigmentation	1.46649753
30	MP0004142_abnormal_muscle_tone	1.46240150
31	MP0000566_synostosis	1.41954984
32	MP0005084_abnormal_gallbladder_morpholo	1.39853255
33	MP0003879_abnormal_hair_cell	1.37584782
34	MP0002064_seizures	1.35919699
35	MP0002733_abnormal_thermal_nociception	1.35812223
36	MP0002693_abnormal_pancreas_physiology	1.35781871
37	MP0002938_white_spotting	1.28133565
38	MP0002572_abnormal_emotion/affect_behav	1.24498910
39	MP0004885_abnormal_endolymph	1.23627595
40	MP0002272_abnormal_nervous_system	1.23264402
41	MP0005410_abnormal_fertilization	1.23047324
42	MP0001970_abnormal_pain_threshold	1.23026999
43	MP0004215_abnormal_myocardial_fiber	1.22803503
44	MP0000613_abnormal_salivary_gland	1.20771047
45	MP0003787_abnormal_imprinting	1.17898319
46	MP0005332_abnormal_amino_acid	1.14627174
47	MP0000631_abnormal_neuroendocrine_gland	1.14600177
48	MP0010329_abnormal_lipoprotein_level	1.14439820
49	MP0002909_abnormal_adrenal_gland	1.14298091
50	MP0005174_abnormal_tail_pigmentation	1.11984768
51	MP0003252_abnormal_bile_duct	1.11044460
52	MP0000230_abnormal_systemic_arterial	1.10309373
53	MP0006072_abnormal_retinal_apoptosis	1.10041897
54	MP0002063_abnormal_learning/memory/cond	1.08249197
55	MP0005379_endocrine/exocrine_gland_phen	1.06619707
56	MP0001486_abnormal_startle_reflex	1.06443764
57	MP0004133_heterotaxia	1.06139294
58	MP0010678_abnormal_skin_adnexa	1.05838917
59	MP0002095_abnormal_skin_pigmentation	1.05051138
60	MP0001664_abnormal_digestion	1.03137917
61	MP0004484_altered_response_of	1.01962042
62	MP0004924_abnormal_behavior	0.99631225
63	MP0005386_behavior/neurological_phenoty	0.99631225
64	MP0000750_abnormal_muscle_regeneration	0.98619789
65	MP0002009_preneoplasia	0.97852259
66	MP0009764_decreased_sensitivity_to	0.97299966
67	MP0002928_abnormal_bile_duct	0.96928424
68	MP0004085_abnormal_heartbeat	0.96749708
69	MP0008058_abnormal_DNA_repair	0.96742614
70	MP0002234_abnormal_pharynx_morphology	0.96442030
71	MP0004145_abnormal_muscle_electrophysio	0.94962064
72	MP0003011_delayed_dark_adaptation	0.94439412
73	MP0002138_abnormal_hepatobiliary_system	0.94047745
74	MP0001944_abnormal_pancreas_morphology	0.93783953
75	MP0002736_abnormal_nociception_after	0.93736278
76	MP0006276_abnormal_autonomic_nervous	0.92462870
77	MP0005646_abnormal_pituitary_gland	0.92281418
78	MP0004084_abnormal_cardiac_muscle	0.92131622
79	MP0004742_abnormal_vestibular_system	0.91817501
80	MP0005365_abnormal_bile_salt	0.91763811
81	MP0002160_abnormal_reproductive_system	0.89636513
82	MP0001764_abnormal_homeostasis	0.89177216
83	MP0005195_abnormal_posterior_eye	0.89170636
84	MP0003635_abnormal_synaptic_transmissio	0.86968430
85	MP0003950_abnormal_plasma_membrane	0.86522561
86	MP0002229_neurodegeneration	0.86420229
87	MP0002184_abnormal_innervation	0.84407272
88	MP0002735_abnormal_chemical_nociception	0.84223264
89	MP0001270_distended_abdomen	0.84002249
90	MP0002557_abnormal_social/conspecific_i	0.83549108
91	MP0000015_abnormal_ear_pigmentation	0.82890843
92	MP0001963_abnormal_hearing_physiology	0.82453397
93	MP0000026_abnormal_inner_ear	0.79496524
94	MP0003136_yellow_coat_color	0.79253665
95	MP0002254_reproductive_system_inflammat	0.78987579
96	MP0004019_abnormal_vitamin_homeostasis	0.78295365
97	MP0005389_reproductive_system_phenotype	0.76604392
98	MP0003137_abnormal_impulse_conducting	0.76368141
99	MP0004270_analgesia	0.75763941
100	MP0003698_abnormal_male_reproductive	0.74205457

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.47682243
2	Hyperalaninemia (HP:0003348)	7.47682243
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.47682243
4	Decreased circulating renin level (HP:0003351)	5.47835413
5	Oral leukoplakia (HP:0002745)	4.42821051
6	Congenital stationary night blindness (HP:0007642)	4.26313737
7	Abnormal drinking behavior (HP:0030082)	4.15478159
8	Polydipsia (HP:0001959)	4.15478159
9	Pancreatic cysts (HP:0001737)	4.04338906
10	Inability to walk (HP:0002540)	3.57947408
11	Ketoacidosis (HP:0001993)	3.56937901
12	Progressive inability to walk (HP:0002505)	3.43459535
13	Tongue fasciculations (HP:0001308)	3.36159716
14	Pancreatic fibrosis (HP:0100732)	3.27744956
15	Attenuation of retinal blood vessels (HP:0007843)	3.24573291
16	Tubular atrophy (HP:0000092)	3.20783726
17	Abnormality of renin-angiotensin system (HP:0000847)	3.13123974
18	Hyperventilation (HP:0002883)	3.11413578
19	Tachypnea (HP:0002789)	3.02768905
20	Abnormality of midbrain morphology (HP:0002418)	3.01953474
21	Molar tooth sign on MRI (HP:0002419)	3.01953474
22	Chorioretinal atrophy (HP:0000533)	3.00969878
23	Alkalosis (HP:0001948)	2.94172257
24	Abnormality of the renal cortex (HP:0011035)	2.87550729
25	Polyuria (HP:0000103)	2.85571560
26	Pendular nystagmus (HP:0012043)	2.83588622
27	Muscle fibrillation (HP:0010546)	2.82573377
28	Febrile seizures (HP:0002373)	2.72950111
29	Abolished electroretinogram (ERG) (HP:0000550)	2.70310802
30	Protruding tongue (HP:0010808)	2.67905256
31	True hermaphroditism (HP:0010459)	2.66602442
32	Impaired smooth pursuit (HP:0007772)	2.66124764
33	Large for gestational age (HP:0001520)	2.61184988
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.57919265
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.55027650
36	Absent/shortened dynein arms (HP:0200106)	2.54271915
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.54271915
38	Nephronophthisis (HP:0000090)	2.52597151
39	Prolonged QT interval (HP:0001657)	2.52104467
40	Ketosis (HP:0001946)	2.47421735
41	Concave nail (HP:0001598)	2.44801269
42	Hypoplastic nipples (HP:0002557)	2.44510601
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40337328
44	Ectopic kidney (HP:0000086)	2.38080392
45	Cystic liver disease (HP:0006706)	2.36467604
46	Abnormality of the renal medulla (HP:0100957)	2.34873597
47	Partial agenesis of the corpus callosum (HP:0001338)	2.34071590
48	Brushfield spots (HP:0001088)	2.32512734
49	Urethral obstruction (HP:0000796)	2.28500854
50	Short chin (HP:0000331)	2.27548862
51	Widely spaced teeth (HP:0000687)	2.27528075
52	Bilateral microphthalmos (HP:0007633)	2.25865321
53	Abnormal urine output (HP:0012590)	2.24084722
54	Polyphagia (HP:0002591)	2.23735312
55	Hypoplasia of the uterus (HP:0000013)	2.23157191
56	Bulbous nose (HP:0000414)	2.22347810
57	Hypokalemia (HP:0002900)	2.21679175
58	Increased corneal curvature (HP:0100692)	2.19989324
59	Keratoconus (HP:0000563)	2.19989324
60	Horseshoe kidney (HP:0000085)	2.16242963
61	Metabolic alkalosis (HP:0200114)	2.14705116
62	Type II lissencephaly (HP:0007260)	2.08953419
63	Decreased central vision (HP:0007663)	2.06363519
64	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04200267
65	Abnormality of renal excretion (HP:0011036)	2.03551858
66	Abnormality of serum amino acid levels (HP:0003112)	2.02767319
67	Arthropathy (HP:0003040)	1.99166465
68	Abnormality of transition element cation homeostasis (HP:0011030)	1.98438491
69	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.98312359
70	Chronic hepatic failure (HP:0100626)	1.97697160
71	Azoospermia (HP:0000027)	1.94401139
72	Bile duct proliferation (HP:0001408)	1.93801858
73	Abnormal biliary tract physiology (HP:0012439)	1.93801858
74	Hyperaldosteronism (HP:0000859)	1.93578725
75	Tented upper lip vermilion (HP:0010804)	1.93373307
76	Small hand (HP:0200055)	1.92917044
77	Vacuolated lymphocytes (HP:0001922)	1.90660338
78	Lissencephaly (HP:0001339)	1.89699116
79	Cupped ear (HP:0000378)	1.87207161
80	Medial flaring of the eyebrow (HP:0010747)	1.86804682
81	Abnormality of potassium homeostasis (HP:0011042)	1.86467534
82	Severe muscular hypotonia (HP:0006829)	1.85997786
83	Abnormal pancreas size (HP:0012094)	1.85891121
84	Furrowed tongue (HP:0000221)	1.85789711
85	Hypoplasia of the fovea (HP:0007750)	1.85754462
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.85754462
87	Broad-based gait (HP:0002136)	1.85666115
88	Progressive cerebellar ataxia (HP:0002073)	1.85567354
89	Gaze-evoked nystagmus (HP:0000640)	1.85210274
90	Abnormality of ocular smooth pursuit (HP:0000617)	1.84014455
91	Squamous cell carcinoma (HP:0002860)	1.80632123
92	Absent speech (HP:0001344)	1.79857377
93	Disproportionate short-trunk short stature (HP:0003521)	1.77137400
94	Conical tooth (HP:0000698)	1.76412329
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75712626
96	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.74745487
97	Duplicated collecting system (HP:0000081)	1.74184363
98	Abnormality of the renal collecting system (HP:0004742)	1.74013536
99	Clumsiness (HP:0002312)	1.72798652
100	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.72633722

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	6.18690778
2	DAPK2	5.73312951
3	WNK4	4.31755614
4	FRK	4.26145786
5	TLK1	4.25295001
6	STK38L	2.78009125
7	MAP4K2	2.51123995
8	GRK1	2.33592186
9	STK39	2.02211014
10	NEK9	2.01106721
11	PINK1	1.96939180
12	ACVR1B	1.72022658
13	BMPR1B	1.67757218
14	STK24	1.64720460
15	ADRBK1	1.60938189
16	WNK3	1.55217181
17	OXSR1	1.43145750
18	NUAK1	1.36540755
19	MAP2K6	1.33552016
20	MUSK	1.31995419
21	MAPKAPK3	1.31260232
22	MAPK13	1.29955717
23	BLK	1.29633733
24	IRAK1	1.25611724
25	TSSK6	1.23526735
26	CASK	1.21453158
27	MKNK2	1.17352786
28	BRSK2	1.10892803
29	PRKCI	1.06557296
30	STK3	1.04703404
31	ZAK	0.99014238
32	PNCK	0.98857560
33	MAP3K4	0.97679156
34	ATR	0.96436724
35	PRKCE	0.95874564
36	WNK1	0.95615782
37	INSRR	0.94707031
38	PHKG1	0.94017606
39	PHKG2	0.94017606
40	PAK3	0.93980067
41	FGFR2	0.93547743
42	TRPM7	0.92066090
43	PRKCG	0.91934327
44	MAPKAPK5	0.91581397
45	PTK2B	0.87588879
46	PRKCQ	0.82065340
47	PKN1	0.76956607
48	TIE1	0.70861219
49	MST4	0.63129328
50	RPS6KA6	0.62069002
51	MET	0.61383746
52	CHEK2	0.60415695
53	CAMK4	0.60096648
54	CAMK2A	0.59169624
55	MAPK11	0.57264446
56	MARK1	0.56549314
57	CAMKK2	0.53543648
58	CAMK1	0.51868518
59	PRKAA2	0.50444470
60	LIMK1	0.48941297
61	NTRK3	0.46178638
62	EEF2K	0.45987455
63	WEE1	0.44306344
64	IKBKB	0.40827003
65	TAOK3	0.38571163
66	PIK3CA	0.36920398
67	ERBB2	0.36688841
68	CSNK1G2	0.35559897
69	PRKAA1	0.35299767
70	SYK	0.34214231
71	TGFBR1	0.34207204
72	STK11	0.32289684
73	MAP2K1	0.32179381
74	FER	0.31752640
75	RPS6KA5	0.30605634
76	MAP2K4	0.30166394
77	PRKACA	0.29149285
78	MAP2K7	0.28733864
79	PRKCZ	0.28524176
80	CSNK1G1	0.26816365
81	ABL1	0.26760804
82	TNK2	0.26419687
83	PRKG1	0.26388833
84	TNIK	0.25931437
85	ITK	0.25784984
86	PRKCA	0.25032351
87	NTRK2	0.24937038
88	LATS1	0.24875476
89	MAPK12	0.24661916
90	TXK	0.24132732
91	CSNK1G3	0.23910343
92	PRKCH	0.22563002
93	JAK3	0.22509391
94	EIF2AK3	0.22205683
95	DAPK3	0.21923660
96	CSF1R	0.21323742
97	CSNK1A1	0.21160417
98	BMX	0.19947911
99	CSNK1D	0.18835145
100	TEC	0.18612279

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	4.59719608
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.16936769
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95535534
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.74027641
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.62104303
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.59012224
7	Histidine metabolism_Homo sapiens_hsa00340	2.53522476
8	Butanoate metabolism_Homo sapiens_hsa00650	2.42450648
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.35622356
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.24983276
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.22944959
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10656938
13	Nicotine addiction_Homo sapiens_hsa05033	1.96909640
14	Morphine addiction_Homo sapiens_hsa05032	1.91977879
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.83572581
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.83086245
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.78744560
18	Olfactory transduction_Homo sapiens_hsa04740	1.73245834
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.72951840
20	Phototransduction_Homo sapiens_hsa04744	1.70549481
21	Caffeine metabolism_Homo sapiens_hsa00232	1.67222698
22	ABC transporters_Homo sapiens_hsa02010	1.64289408
23	Taste transduction_Homo sapiens_hsa04742	1.63534481
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.60975154
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59570438
26	Circadian entrainment_Homo sapiens_hsa04713	1.59500272
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.59455372
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57816938
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53622683
30	GABAergic synapse_Homo sapiens_hsa04727	1.42437681
31	Sulfur metabolism_Homo sapiens_hsa00920	1.42003417
32	Basal transcription factors_Homo sapiens_hsa03022	1.38046356
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.35204099
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30915896
35	Homologous recombination_Homo sapiens_hsa03440	1.23630178
36	One carbon pool by folate_Homo sapiens_hsa00670	1.22886822
37	Insulin secretion_Homo sapiens_hsa04911	1.20321326
38	Serotonergic synapse_Homo sapiens_hsa04726	1.17824173
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16221784
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14686661
41	RNA polymerase_Homo sapiens_hsa03020	1.14431760
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13513154
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.12520882
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.08122139
45	Glycerolipid metabolism_Homo sapiens_hsa00561	1.08039040
46	Lysine degradation_Homo sapiens_hsa00310	1.07718977
47	Peroxisome_Homo sapiens_hsa04146	0.99632580
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.96508131
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85412190
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81497077
51	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79094316
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78157769
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76665996
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.74211676
55	Salivary secretion_Homo sapiens_hsa04970	0.72678904
56	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70590412
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70562976
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69786594
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.68157413
60	Mineral absorption_Homo sapiens_hsa04978	0.63476574
61	Propanoate metabolism_Homo sapiens_hsa00640	0.61111597
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60052496
63	Protein export_Homo sapiens_hsa03060	0.58499627
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57718139
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57548057
66	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.57326633
67	Sulfur relay system_Homo sapiens_hsa04122	0.57005195
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53856170
69	Lysosome_Homo sapiens_hsa04142	0.53190657
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52740262
71	Cholinergic synapse_Homo sapiens_hsa04725	0.52284105
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52058492
73	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51800526
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.51618339
75	Pancreatic secretion_Homo sapiens_hsa04972	0.50281487
76	Retinol metabolism_Homo sapiens_hsa00830	0.48871031
77	Long-term depression_Homo sapiens_hsa04730	0.46362870
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44828135
79	RNA degradation_Homo sapiens_hsa03018	0.44286782
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.43849024
81	Metabolic pathways_Homo sapiens_hsa01100	0.40790255
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39110872
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39073371
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.37294598
85	Gastric acid secretion_Homo sapiens_hsa04971	0.35293087
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34256163
87	Purine metabolism_Homo sapiens_hsa00230	0.32097449
88	Regulation of autophagy_Homo sapiens_hsa04140	0.30797084
89	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30329627
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.29236100
91	Bile secretion_Homo sapiens_hsa04976	0.28664681
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.27561773
93	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26801015
94	Fatty acid degradation_Homo sapiens_hsa00071	0.23454231
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21738969
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21614380
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.21286362
98	Pyrimidine metabolism_Homo sapiens_hsa00240	0.20451162
99	Oxidative phosphorylation_Homo sapiens_hsa00190	0.18872871
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.18551351

AKR1B10P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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