AKR1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* aminoglycoside antibiotic metabolic process (GO:0030647)9.31508323
2primary alcohol catabolic process (GO:0034310)7.24645025
3negative regulation of fibrinolysis (GO:0051918)6.72161979
4cellular glucuronidation (GO:0052695)6.11079328
5regulation of fibrinolysis (GO:0051917)6.07356851
6L-phenylalanine catabolic process (GO:0006559)6.06173453
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06173453
8L-phenylalanine metabolic process (GO:0006558)5.99233828
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.99233828
10regulation of protein activation cascade (GO:2000257)5.93136348
11glucuronate metabolic process (GO:0019585)5.75652124
12uronic acid metabolic process (GO:0006063)5.75652124
13regulation of complement activation (GO:0030449)5.59802329
14ethanol oxidation (GO:0006069)5.51127371
15protein carboxylation (GO:0018214)5.44573873
16peptidyl-glutamic acid carboxylation (GO:0017187)5.44573873
17complement activation, alternative pathway (GO:0006957)5.18602244
18* glycoside metabolic process (GO:0016137)4.97387475
19* progesterone metabolic process (GO:0042448)4.69711998
20regulation of plasminogen activation (GO:0010755)4.69633975
21very-low-density lipoprotein particle assembly (GO:0034379)4.67007576
22ethanol metabolic process (GO:0006067)4.65660632
23fibrinolysis (GO:0042730)4.61549452
24negative regulation of protein activation cascade (GO:2000258)4.37730092
25plasma lipoprotein particle clearance (GO:0034381)4.36594395
26urea metabolic process (GO:0019627)4.35547296
27regulation of cholesterol esterification (GO:0010872)4.34877202
28blood coagulation, intrinsic pathway (GO:0007597)4.33797175
29exogenous drug catabolic process (GO:0042738)4.18509896
30* intestinal cholesterol absorption (GO:0030299)4.15981782
31negative regulation of sterol transport (GO:0032372)4.11724101
32negative regulation of cholesterol transport (GO:0032375)4.11724101
33glyoxylate metabolic process (GO:0046487)4.10921586
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04189388
35primary alcohol metabolic process (GO:0034308)3.99354291
36plasma lipoprotein particle remodeling (GO:0034369)3.99241755
37protein-lipid complex remodeling (GO:0034368)3.99241755
38macromolecular complex remodeling (GO:0034367)3.99241755
39nitrogen cycle metabolic process (GO:0071941)3.97587675
40low-density lipoprotein particle clearance (GO:0034383)3.96661416
41drug catabolic process (GO:0042737)3.95283625
42cysteine metabolic process (GO:0006534)3.91839080
43urea cycle (GO:0000050)3.90660628
44* quinone metabolic process (GO:1901661)3.88845303
45flavonoid metabolic process (GO:0009812)3.86623148
46plasma lipoprotein particle assembly (GO:0034377)3.84863470
47negative regulation of blood coagulation (GO:0030195)3.80179304
48negative regulation of hemostasis (GO:1900047)3.80179304
49aromatic amino acid family catabolic process (GO:0009074)3.76519485
50cholesterol efflux (GO:0033344)3.75436846
51negative regulation of lipase activity (GO:0060192)3.73736116
52triglyceride homeostasis (GO:0070328)3.73204403
53acylglycerol homeostasis (GO:0055090)3.73204403
54acute-phase response (GO:0006953)3.73121725
55low-density lipoprotein particle remodeling (GO:0034374)3.68325267
56positive regulation of lipoprotein lipase activity (GO:0051006)3.65534966
57positive regulation of triglyceride lipase activity (GO:0061365)3.65534966
58positive regulation of blood coagulation (GO:0030194)3.64501195
59positive regulation of hemostasis (GO:1900048)3.64501195
60negative regulation of complement activation (GO:0045916)3.63910483
61protein activation cascade (GO:0072376)3.63857928
62regulation of apoptotic cell clearance (GO:2000425)3.63766108
63epoxygenase P450 pathway (GO:0019373)3.61722382
64negative regulation of coagulation (GO:0050819)3.58121388
65protein-lipid complex assembly (GO:0065005)3.57273886
66high-density lipoprotein particle remodeling (GO:0034375)3.56797776
67* bile acid metabolic process (GO:0008206)3.54294026
68* C21-steroid hormone metabolic process (GO:0008207)3.52261268
69phospholipid efflux (GO:0033700)3.50573618
70regulation of triglyceride catabolic process (GO:0010896)3.48530244
71complement activation, classical pathway (GO:0006958)3.47420025
72drug metabolic process (GO:0017144)3.46883751
73negative regulation of wound healing (GO:0061045)3.44911939
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.44676834
75bile acid biosynthetic process (GO:0006699)3.42404138
76positive regulation of extracellular matrix organization (GO:1903055)3.38699797
77positive regulation of coagulation (GO:0050820)3.38593689
78* retinal metabolic process (GO:0042574)3.37567189
79alpha-linolenic acid metabolic process (GO:0036109)3.36137708
80cyclooxygenase pathway (GO:0019371)3.32361483
81plasma lipoprotein particle organization (GO:0071827)3.32216217
82glutamate metabolic process (GO:0006536)3.30397795
83complement activation (GO:0006956)3.27717905
84acylglycerol catabolic process (GO:0046464)3.27655737
85neutral lipid catabolic process (GO:0046461)3.27655737
86response to nitrosative stress (GO:0051409)3.25762689
87reverse cholesterol transport (GO:0043691)3.23936614
88tyrosine metabolic process (GO:0006570)3.23321969
89regulation of humoral immune response (GO:0002920)3.21200534
90protein-lipid complex subunit organization (GO:0071825)3.20358096
91amino-acid betaine metabolic process (GO:0006577)3.20142090
92phenylpropanoid metabolic process (GO:0009698)3.17926556
93drug transmembrane transport (GO:0006855)3.13564097
94triglyceride catabolic process (GO:0019433)3.11686923
95response to prostaglandin (GO:0034694)3.10896129
96omega-hydroxylase P450 pathway (GO:0097267)3.09995641
97L-ascorbic acid metabolic process (GO:0019852)3.09790531
98* polyketide metabolic process (GO:0030638)10.6235793
99* doxorubicin metabolic process (GO:0044598)10.6235793
100* daunorubicin metabolic process (GO:0044597)10.6235793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.61052829
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.57045418
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.37233193
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.52590212
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.48656220
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.97922493
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71579409
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.20815543
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.18163835
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.04028637
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.02658137
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.02272180
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.60405010
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56467609
15CLOCK_20551151_ChIP-Seq_293T_Human2.47066891
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.26449218
17HNF4A_19822575_ChIP-Seq_HepG2_Human2.06674449
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99649217
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92438853
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92430144
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90559222
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82899307
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77107540
24ZNF263_19887448_ChIP-Seq_K562_Human1.70290843
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70257845
26* GATA4_25053715_ChIP-Seq_YYC3_Human1.54386098
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52467979
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51286923
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51252885
30SOX2_20726797_ChIP-Seq_SW620_Human1.48507602
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47977426
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.46694630
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46328539
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44280293
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44280293
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42135012
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.40990854
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34132932
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.31713330
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.29516587
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27742213
42* CJUN_26792858_Chip-Seq_BT549_Human1.26658505
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25650459
44* GATA6_25053715_ChIP-Seq_YYC3_Human1.20577874
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.17406595
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16610601
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15196043
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12964914
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12272460
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10630929
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05594177
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04249625
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02925815
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02787485
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02195440
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01310975
57P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97673163
58CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97314000
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96980969
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96863017
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95029735
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94871349
63GATA2_21666600_ChIP-Seq_HMVEC_Human0.94811820
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93100662
65GATA3_24758297_ChIP-Seq_MCF-7_Human0.90802498
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90737894
67ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90108394
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90068634
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89322760
70* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89305273
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89305273
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86682102
73TBX20_22080862_ChIP-Seq_HEART_Mouse0.83138569
74TBX20_22328084_ChIP-Seq_HEART_Mouse0.83138569
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82695882
76EP300_21415370_ChIP-Seq_HL-1_Mouse0.81481808
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81353376
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79576526
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79550511
80CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78901901
81RACK7_27058665_Chip-Seq_MCF-7_Human0.78391685
82FOXA1_25552417_ChIP-Seq_VCAP_Human0.77712442
83SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77326127
84* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76330744
85TP53_18474530_ChIP-ChIP_U2OS_Human0.75874334
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.74942972
87LXR_22292898_ChIP-Seq_THP-1_Human0.74891978
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74684998
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72839792
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72238713
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.70366532
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70294310
93EOMES_21245162_ChIP-Seq_HESCs_Human0.69858550
94PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69178075
95ATF3_27146783_Chip-Seq_COLON_Human0.68402636
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.68212277
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67655810
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.67586381
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66551597
100SMAD1_18555785_Chip-Seq_ESCs_Mouse0.66015468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.52273578
2MP0005365_abnormal_bile_salt5.51691809
3MP0005360_urolithiasis4.83477001
4MP0005085_abnormal_gallbladder_physiolo4.59650506
5MP0008875_abnormal_xenobiotic_pharmacok4.58693391
6MP0003195_calcinosis3.59598906
7MP0003868_abnormal_feces_composition3.37973211
8MP0001666_abnormal_nutrient_absorption3.26435919
9MP0003252_abnormal_bile_duct3.22733911
10MP0010329_abnormal_lipoprotein_level3.09000503
11MP0008438_abnormal_cutaneous_collagen2.53466655
12MP0009840_abnormal_foam_cell2.44353404
13MP0005670_abnormal_white_adipose2.35627918
14MP0005332_abnormal_amino_acid2.19444947
15MP0002138_abnormal_hepatobiliary_system2.03184483
16MP0004272_abnormal_basement_membrane1.94458792
17MP0002118_abnormal_lipid_homeostasis1.92312719
18MP0000609_abnormal_liver_physiology1.83785234
19MP0003806_abnormal_nucleotide_metabolis1.80039204
20MP0002876_abnormal_thyroid_physiology1.70653102
21MP0001661_extended_life_span1.67023831
22MP0004019_abnormal_vitamin_homeostasis1.66567480
23MP0003186_abnormal_redox_activity1.61909856
24MP0002971_abnormal_brown_adipose1.50490152
25MP0003191_abnormal_cellular_cholesterol1.47286003
26MP0005408_hypopigmentation1.46999585
27MP0003950_abnormal_plasma_membrane1.42069750
28MP0005058_abnormal_lysosome_morphology1.38964914
29MP0005666_abnormal_adipose_tissue1.35788529
30MP0009697_abnormal_copulation1.35550057
31MP0005164_abnormal_response_to1.32944771
32MP0005451_abnormal_body_composition1.29701948
33MP0005275_abnormal_skin_tensile1.29055127
34MP0005503_abnormal_tendon_morphology1.25982567
35MP0005319_abnormal_enzyme/_coenzyme1.20867119
36MP0009780_abnormal_chondrocyte_physiolo1.20508707
37MP0001915_intracranial_hemorrhage1.19512715
38MP0010368_abnormal_lymphatic_system1.17665136
39MP0009643_abnormal_urine_homeostasis1.16660403
40MP0003566_abnormal_cell_adhesion1.15413604
41MP0000604_amyloidosis1.14275217
42MP0003656_abnormal_erythrocyte_physiolo1.13182807
43MP0002132_abnormal_respiratory_system1.10137211
44MP0005584_abnormal_enzyme/coenzyme_acti1.08697171
45MP0005257_abnormal_intraocular_pressure1.08565432
46MP0005375_adipose_tissue_phenotype1.08171544
47MP0005023_abnormal_wound_healing1.07015303
48MP0003705_abnormal_hypodermis_morpholog1.00990404
49MP0001764_abnormal_homeostasis1.00325717
50MP0000598_abnormal_liver_morphology0.98559298
51MP0004130_abnormal_muscle_cell0.92385069
52MP0000003_abnormal_adipose_tissue0.90516388
53MP0006054_spinal_hemorrhage0.88412590
54MP0002089_abnormal_postnatal_growth/wei0.87792718
55MP0000566_synostosis0.85401025
56MP0009115_abnormal_fat_cell0.84971403
57MP0005083_abnormal_biliary_tract0.84939655
58MP0003959_abnormal_lean_body0.81882562
59MP0005334_abnormal_fat_pad0.80650741
60MP0002970_abnormal_white_adipose0.80621443
61MP0003690_abnormal_glial_cell0.80214289
62MP0004883_abnormal_blood_vessel0.78956253
63MP0005636_abnormal_mineral_homeostasis0.78740205
64MP0003011_delayed_dark_adaptation0.78343559
65MP0009642_abnormal_blood_homeostasis0.77428403
66MP0004185_abnormal_adipocyte_glucose0.76678389
67MP0005376_homeostasis/metabolism_phenot0.75262237
68MP0002078_abnormal_glucose_homeostasis0.71931672
69MP0004782_abnormal_surfactant_physiolog0.70474810
70MP0000858_altered_metastatic_potential0.69938732
71MP0009763_increased_sensitivity_to0.69729384
72MP0003122_maternal_imprinting0.68180553
73MP0003329_amyloid_beta_deposits0.67750015
74MP0002295_abnormal_pulmonary_circulatio0.66157958
75MP0008469_abnormal_protein_level0.66045128
76MP0002909_abnormal_adrenal_gland0.65854001
77MP0005167_abnormal_blood-brain_barrier0.65604794
78MP0001756_abnormal_urination0.63026271
79MP0000249_abnormal_blood_vessel0.62682718
80MP0002168_other_aberrant_phenotype0.62590030
81MP0002060_abnormal_skin_morphology0.62340401
82MP0005448_abnormal_energy_balance0.60561965
83MP0005165_increased_susceptibility_to0.59191902
84MP0005464_abnormal_platelet_physiology0.59148620
85MP0009053_abnormal_anal_canal0.58384528
86MP0000467_abnormal_esophagus_morphology0.56598462
87MP0001958_emphysema0.56382083
88MP0000013_abnormal_adipose_tissue0.56147623
89MP0002933_joint_inflammation0.56005736
90MP0003638_abnormal_response/metabolism_0.55816306
91MP0009384_cardiac_valve_regurgitation0.55459988
92MP0002108_abnormal_muscle_morphology0.54586345
93MP0002896_abnormal_bone_mineralization0.54453868
94MP0006138_congestive_heart_failure0.52740878
95MP0003941_abnormal_skin_development0.51685770
96MP0005535_abnormal_body_temperature0.50352804
97MP0003075_altered_response_to0.47849230
98MP0008260_abnormal_autophagy0.47710658
99MP0002136_abnormal_kidney_physiology0.46872338
100MP0005395_other_phenotype0.46745982

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)8.42206915
2Abnormality of monocarboxylic acid metabolism (HP:0010996)7.13857795
3Complement deficiency (HP:0004431)6.88103911
4Hypobetalipoproteinemia (HP:0003563)6.01490394
5Prolonged partial thromboplastin time (HP:0003645)6.01201450
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.91730880
7Abnormality of complement system (HP:0005339)5.82618968
8Conjugated hyperbilirubinemia (HP:0002908)5.40056252
9Systemic lupus erythematosus (HP:0002725)5.18049621
10Abnormality of the common coagulation pathway (HP:0010990)4.89030794
11Glomerulonephritis (HP:0000099)4.84482897
12Joint hemorrhage (HP:0005261)4.73319681
13Xanthomatosis (HP:0000991)4.53209979
14Fat malabsorption (HP:0002630)4.13384580
15Vascular calcification (HP:0004934)4.08141808
16Hypolipoproteinemia (HP:0010981)3.91631219
17Cardiovascular calcification (HP:0011915)3.87320687
18Mitral stenosis (HP:0001718)3.87288908
19Spontaneous abortion (HP:0005268)3.84211270
20Intrahepatic cholestasis (HP:0001406)3.72978004
21Steatorrhea (HP:0002570)3.63088521
22Abnormal sex determination (HP:0012244)3.62976987
23Sex reversal (HP:0012245)3.62976987
24Hemorrhage of the eye (HP:0011885)3.62677493
25Hypercholesterolemia (HP:0003124)3.51081246
26Protrusio acetabuli (HP:0003179)3.50789545
27Nephritis (HP:0000123)3.38978244
28Hyperlipoproteinemia (HP:0010980)3.35398122
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.31336408
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.27123455
31Vertebral compression fractures (HP:0002953)3.19986270
32Rickets (HP:0002748)3.03747900
33Epidermoid cyst (HP:0200040)2.90168293
34Back pain (HP:0003418)2.82415987
35Abnormality of the Achilles tendon (HP:0005109)2.81561647
36Hydroxyprolinuria (HP:0003080)2.77789169
37Abnormality of proline metabolism (HP:0010907)2.77789169
38Skin nodule (HP:0200036)2.72036975
39Gingival bleeding (HP:0000225)2.69884518
40Hypoalphalipoproteinemia (HP:0003233)2.67061794
41Myocardial infarction (HP:0001658)2.65946186
42Abnormality of the intrinsic pathway (HP:0010989)2.65518610
43Arthropathy (HP:0003040)2.51848897
44Generalized aminoaciduria (HP:0002909)2.49873153
45Purpura (HP:0000979)2.44943133
46Abnormality of carpal bone ossification (HP:0006257)2.42261933
47Menorrhagia (HP:0000132)2.40195879
48Hyperammonemia (HP:0001987)2.37299569
49Hepatocellular carcinoma (HP:0001402)2.20856240
50Urinary glycosaminoglycan excretion (HP:0003541)2.17087746
51Mucopolysacchariduria (HP:0008155)2.17087746
52Amyloidosis (HP:0011034)2.15514226
53Abnormal delivery (HP:0001787)2.12764068
54Osteomalacia (HP:0002749)2.11061408
55Abnormality of pyrimidine metabolism (HP:0004353)2.10796463
56Vascular tortuosity (HP:0004948)2.10126036
57Hyperbilirubinemia (HP:0002904)2.05429314
58Tetraparesis (HP:0002273)2.01852742
59Increased serum pyruvate (HP:0003542)1.97185272
60Arterial tortuosity (HP:0005116)1.95074407
61Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94715497
62Abnormality of polysaccharide metabolism (HP:0011012)1.94715497
63Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94715497
64Hypertriglyceridemia (HP:0002155)1.94077010
65Polycythemia (HP:0001901)1.93951884
66Hypophosphatemic rickets (HP:0004912)1.90856797
67Abnormal cartilage morphology (HP:0002763)1.86679758
68Reduced antithrombin III activity (HP:0001976)1.85768958
69Abnormality of glycolysis (HP:0004366)1.85449072
70Premature rupture of membranes (HP:0001788)1.84398376
71Recurrent gram-negative bacterial infections (HP:0005420)1.83602670
72Thrombophlebitis (HP:0004418)1.82035572
73Bifid scrotum (HP:0000048)1.81216233
74Abnormality of the acetabulum (HP:0003170)1.80828369
75Cervical subluxation (HP:0003308)1.80361906
76Increased serum ferritin (HP:0003281)1.79858800
77Acanthocytosis (HP:0001927)1.77554063
78Facial shape deformation (HP:0011334)1.76348537
79Potter facies (HP:0002009)1.76348537
80Beaking of vertebral bodies (HP:0004568)1.75333714
81Ovoid vertebral bodies (HP:0003300)1.72960647
82Flat acetabular roof (HP:0003180)1.72004185
83Abnormal ossification of hand bones (HP:0005921)1.71823968
84Abnormality of methionine metabolism (HP:0010901)1.70318842
85Joint swelling (HP:0001386)1.69144232
86Abnormality of iron homeostasis (HP:0011031)1.68424121
87Abnormal tarsal ossification (HP:0008369)1.68145035
88Abnormal hand bone ossification (HP:0010660)1.65848794
89Abnormality of vitamin metabolism (HP:0100508)1.64566933
90Hyperglycinemia (HP:0002154)1.64136334
91Peritonitis (HP:0002586)1.63674617
92Hypoglycemic coma (HP:0001325)1.63129559
93Abnormality of nucleobase metabolism (HP:0010932)1.62340385
94Glomerulosclerosis (HP:0000096)1.61799189
95Elevated alkaline phosphatase (HP:0003155)1.60923176
96Abnormal gallbladder physiology (HP:0012438)1.58774828
97Cholecystitis (HP:0001082)1.58774828
98Abnormality of fatty-acid metabolism (HP:0004359)1.58159815
99Acanthosis nigricans (HP:0000956)1.58109809
100Neonatal death (HP:0003811)1.57294863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.54427892
2ERN14.50615038
3IRAK33.01118631
4PDGFRA2.96982379
5MST1R2.91721271
6DDR22.80457417
7RIPK12.71586482
8ICK2.54884066
9ERBB42.51481558
10FGFR32.48363996
11LATS22.29069371
12TRIB32.06673991
13SIK12.04033997
14EPHA31.89403920
15TGFBR21.85025491
16MET1.75645613
17EPHA21.75588770
18MAPKAPK31.72092358
19TESK11.65370850
20LATS11.60188784
21PRKAA21.48445249
22MAP3K31.47728712
23MYLK1.45564083
24MAP3K21.34348572
25NEK91.32229688
26MAP3K121.21029579
27TBK11.18478447
28SCYL21.18103454
29ABL21.17679547
30NTRK11.12104839
31LMTK21.10882607
32STK381.08705822
33CDC42BPA1.04801553
34MAPK111.04689440
35EIF2AK11.02402252
36PDPK11.01017701
37EPHB11.00982326
38TYRO31.00358658
39PTK20.94454412
40KSR20.89210424
41PDGFRB0.88789552
42ARAF0.87486568
43ACVR1B0.85320842
44MAP3K60.84101021
45PAK40.79309093
46CDK120.79133872
47RET0.75387963
48TYK20.75038928
49PRKACG0.73549274
50FER0.72825459
51MAP3K10.71449449
52PIM20.71195896
53DYRK1B0.67173407
54PIK3CA0.66623355
55PRKAA10.65246750
56MAPKAPK50.64398251
57EEF2K0.64220626
58CDK60.62409448
59PIK3CG0.61593071
60IGF1R0.60299085
61PRPF4B0.58520320
62PBK0.58057976
63PKN20.57068499
64WNK40.54515886
65MAPK150.54191186
66PRKG20.53638321
67TAOK20.53418695
68MAP2K10.52815548
69FGFR10.52577957
70CDK90.52171745
71JAK10.52169911
72FLT30.49831267
73TRPM70.49561960
74MTOR0.48903591
75GSK3A0.48627797
76MATK0.48267699
77PAK20.47968198
78WNK10.47864335
79EPHB20.47794610
80ZAP700.47763148
81STK38L0.47743572
82ERBB20.46520649
83AKT30.46287009
84LIMK10.45001794
85MAP3K70.44794519
86GRK50.42638046
87NLK0.42187370
88MAP2K30.41509729
89SRC0.40484169
90MAP2K40.38926768
91SGK2230.38215451
92SGK4940.38215451
93SGK30.37817532
94GRK10.37638243
95BMX0.37279556
96CAMK1D0.34859907
97IRAK10.34731813
98AKT20.34059951
99MAP3K90.33831618
100PDK20.33137687

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.15693147
2Complement and coagulation cascades_Homo sapiens_hsa046103.71426663
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.60170289
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10535213
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.01375508
6Chemical carcinogenesis_Homo sapiens_hsa052042.96394471
7* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.89419352
8* Steroid hormone biosynthesis_Homo sapiens_hsa001402.81435499
9Retinol metabolism_Homo sapiens_hsa008302.78078043
10Phenylalanine metabolism_Homo sapiens_hsa003602.75930851
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.73576239
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.36021031
13Fatty acid degradation_Homo sapiens_hsa000712.32933781
14Tyrosine metabolism_Homo sapiens_hsa003502.26765032
15Histidine metabolism_Homo sapiens_hsa003402.23577672
16Arginine biosynthesis_Homo sapiens_hsa002202.18382005
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13055423
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.04297959
19Starch and sucrose metabolism_Homo sapiens_hsa005002.01714427
20PPAR signaling pathway_Homo sapiens_hsa033201.94909473
21Caffeine metabolism_Homo sapiens_hsa002321.93542806
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76033647
23Fat digestion and absorption_Homo sapiens_hsa049751.55894520
24Bile secretion_Homo sapiens_hsa049761.54319605
25Tryptophan metabolism_Homo sapiens_hsa003801.51776755
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50339806
27beta-Alanine metabolism_Homo sapiens_hsa004101.45850506
28Pyruvate metabolism_Homo sapiens_hsa006201.37616174
29Fatty acid metabolism_Homo sapiens_hsa012121.32200910
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27390692
31Glutathione metabolism_Homo sapiens_hsa004801.23848628
32Arginine and proline metabolism_Homo sapiens_hsa003301.22453964
33Butanoate metabolism_Homo sapiens_hsa006501.22331346
34Glycerolipid metabolism_Homo sapiens_hsa005611.22299513
35Vitamin B6 metabolism_Homo sapiens_hsa007501.21483198
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17441466
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12325947
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10727940
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.09655833
40Peroxisome_Homo sapiens_hsa041461.09386915
41Staphylococcus aureus infection_Homo sapiens_hsa051501.03559552
42Fatty acid biosynthesis_Homo sapiens_hsa000611.03332297
43ABC transporters_Homo sapiens_hsa020101.02219341
44Carbon metabolism_Homo sapiens_hsa012001.02055556
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01520405
46Arachidonic acid metabolism_Homo sapiens_hsa005900.96534875
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96349969
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.96258865
49Biosynthesis of amino acids_Homo sapiens_hsa012300.95812375
50Fructose and mannose metabolism_Homo sapiens_hsa000510.93521571
51Galactose metabolism_Homo sapiens_hsa000520.92567288
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91735584
53Propanoate metabolism_Homo sapiens_hsa006400.91295225
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89291080
55Steroid biosynthesis_Homo sapiens_hsa001000.86620650
56Other glycan degradation_Homo sapiens_hsa005110.80771935
57Sulfur metabolism_Homo sapiens_hsa009200.79778520
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74512475
59Vitamin digestion and absorption_Homo sapiens_hsa049770.69912157
60Prion diseases_Homo sapiens_hsa050200.68822509
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.66769863
62Linoleic acid metabolism_Homo sapiens_hsa005910.66636172
63Pentose phosphate pathway_Homo sapiens_hsa000300.66352497
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60589825
65Fatty acid elongation_Homo sapiens_hsa000620.59001548
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58526115
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48783799
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.46457680
69ECM-receptor interaction_Homo sapiens_hsa045120.45060643
70Renin-angiotensin system_Homo sapiens_hsa046140.44654469
71Sulfur relay system_Homo sapiens_hsa041220.42809953
72Lysine degradation_Homo sapiens_hsa003100.42739858
73Metabolic pathways_Homo sapiens_hsa011000.40870728
74Pertussis_Homo sapiens_hsa051330.38075370
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36402873
76One carbon pool by folate_Homo sapiens_hsa006700.35797640
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34175239
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31677237
79Mineral absorption_Homo sapiens_hsa049780.31476930
80Insulin resistance_Homo sapiens_hsa049310.30103965
81Protein digestion and absorption_Homo sapiens_hsa049740.27223754
82Sphingolipid metabolism_Homo sapiens_hsa006000.23824170
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23251406
84Selenocompound metabolism_Homo sapiens_hsa004500.23199657
85N-Glycan biosynthesis_Homo sapiens_hsa005100.20652854
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18265101
87AMPK signaling pathway_Homo sapiens_hsa041520.18200556
88Ovarian steroidogenesis_Homo sapiens_hsa049130.16046465
89Lysosome_Homo sapiens_hsa041420.14708010
90Thyroid hormone synthesis_Homo sapiens_hsa049180.08409286
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.07808681
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.06790638
93Nitrogen metabolism_Homo sapiens_hsa009100.06727588
94Amoebiasis_Homo sapiens_hsa051460.04635442
95Insulin signaling pathway_Homo sapiens_hsa049100.02620673
96Glucagon signaling pathway_Homo sapiens_hsa049220.02444718
97Pancreatic secretion_Homo sapiens_hsa049720.02182830
98Focal adhesion_Homo sapiens_hsa045100.01394278
99Folate biosynthesis_Homo sapiens_hsa00790-0.0524733
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0334866

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »