AKR1C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary alcohol catabolic process (GO:0034310)9.51597582
2cellular glucuronidation (GO:0052695)7.17755019
3glucuronate metabolic process (GO:0019585)6.75849775
4uronic acid metabolic process (GO:0006063)6.75849775
5ethanol oxidation (GO:0006069)6.24927460
6retinal metabolic process (GO:0042574)6.10464037
7intestinal cholesterol absorption (GO:0030299)5.94486803
8* glycoside metabolic process (GO:0016137)5.72393326
9negative regulation of fibrinolysis (GO:0051918)5.70942731
10L-phenylalanine metabolic process (GO:0006558)5.65270959
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65270959
12ethanol metabolic process (GO:0006067)5.48733667
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46928314
14L-phenylalanine catabolic process (GO:0006559)5.46928314
15exogenous drug catabolic process (GO:0042738)5.34411723
16regulation of fibrinolysis (GO:0051917)5.13491446
17primary alcohol metabolic process (GO:0034308)4.96645062
18* progesterone metabolic process (GO:0042448)4.95754646
19drug catabolic process (GO:0042737)4.91623110
20flavonoid metabolic process (GO:0009812)4.83733717
21regulation of protein activation cascade (GO:2000257)4.57968544
22urea metabolic process (GO:0019627)4.56353125
23fibrinolysis (GO:0042730)4.51184214
24* quinone metabolic process (GO:1901661)4.45773172
25phenylpropanoid metabolic process (GO:0009698)4.41634700
26cellular aldehyde metabolic process (GO:0006081)4.37891245
27bile acid metabolic process (GO:0008206)4.37747492
28protein carboxylation (GO:0018214)4.32255660
29peptidyl-glutamic acid carboxylation (GO:0017187)4.32255660
30complement activation, alternative pathway (GO:0006957)4.29901556
31regulation of complement activation (GO:0030449)4.22102728
32nitrogen cycle metabolic process (GO:0071941)4.15774621
33bile acid and bile salt transport (GO:0015721)4.09108730
34glyoxylate metabolic process (GO:0046487)4.07385019
35low-density lipoprotein particle clearance (GO:0034383)4.05674930
36regulation of plasminogen activation (GO:0010755)4.04215617
37epoxygenase P450 pathway (GO:0019373)3.98837346
38drug metabolic process (GO:0017144)3.96359603
39regulation of triglyceride catabolic process (GO:0010896)3.93033273
40cysteine metabolic process (GO:0006534)3.91565805
41urea cycle (GO:0000050)3.90927545
42acylglycerol homeostasis (GO:0055090)3.80952155
43triglyceride homeostasis (GO:0070328)3.80952155
44cyclooxygenase pathway (GO:0019371)3.77441268
45plasma lipoprotein particle clearance (GO:0034381)3.76223794
46triglyceride catabolic process (GO:0019433)3.75914764
47alpha-linolenic acid metabolic process (GO:0036109)3.64447381
48* C21-steroid hormone metabolic process (GO:0008207)3.62640608
49negative regulation of lipase activity (GO:0060192)3.60175766
50bile acid biosynthetic process (GO:0006699)3.59224718
51neutral lipid catabolic process (GO:0046461)3.59113482
52acylglycerol catabolic process (GO:0046464)3.59113482
53amino-acid betaine metabolic process (GO:0006577)3.57734385
54intestinal absorption (GO:0050892)3.55388654
55aromatic amino acid family catabolic process (GO:0009074)3.53213198
56omega-hydroxylase P450 pathway (GO:0097267)3.52278584
57response to nitrosative stress (GO:0051409)3.50171992
58negative regulation of blood coagulation (GO:0030195)3.47605759
59negative regulation of hemostasis (GO:1900047)3.47605759
60retinoid metabolic process (GO:0001523)3.44540018
61blood coagulation, intrinsic pathway (GO:0007597)3.43812945
62acute-phase response (GO:0006953)3.42966835
63diterpenoid metabolic process (GO:0016101)3.40519878
64terpenoid metabolic process (GO:0006721)3.36890715
65very-low-density lipoprotein particle assembly (GO:0034379)3.32269230
66negative regulation of sterol transport (GO:0032372)3.31438622
67negative regulation of cholesterol transport (GO:0032375)3.31438622
68positive regulation of triglyceride lipase activity (GO:0061365)3.30368934
69positive regulation of lipoprotein lipase activity (GO:0051006)3.30368934
70negative regulation of coagulation (GO:0050819)3.28408688
71positive regulation of endothelial cell apoptotic process (GO:2000353)3.28244635
72drug transmembrane transport (GO:0006855)3.25778282
73xenobiotic metabolic process (GO:0006805)3.24798914
74retinol metabolic process (GO:0042572)3.21815682
75negative regulation of wound healing (GO:0061045)3.21787279
76retinoic acid metabolic process (GO:0042573)3.21096870
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12871045
78regulation of cholesterol esterification (GO:0010872)3.11786821
79positive regulation of blood coagulation (GO:0030194)3.11658906
80positive regulation of hemostasis (GO:1900048)3.11658906
81* secondary metabolic process (GO:0019748)3.09428045
82negative regulation of protein activation cascade (GO:2000258)3.08335348
83pentose-phosphate shunt (GO:0006098)3.06448771
84NADPH regeneration (GO:0006740)3.01751738
85cofactor catabolic process (GO:0051187)3.00976606
86coenzyme catabolic process (GO:0009109)2.99943284
87androgen biosynthetic process (GO:0006702)2.97681130
88positive regulation of lipid catabolic process (GO:0050996)2.96206689
89tyrosine metabolic process (GO:0006570)2.95103532
90negative regulation of fatty acid biosynthetic process (GO:0045717)2.94295248
91xenobiotic catabolic process (GO:0042178)2.93938997
92protein-lipid complex remodeling (GO:0034368)2.93330132
93macromolecular complex remodeling (GO:0034367)2.93330132
94plasma lipoprotein particle remodeling (GO:0034369)2.93330132
95fatty acid homeostasis (GO:0055089)2.93154409
96positive regulation of coagulation (GO:0050820)2.91954778
97* daunorubicin metabolic process (GO:0044597)12.6368709
98* polyketide metabolic process (GO:0030638)12.6368709
99* doxorubicin metabolic process (GO:0044598)12.6368709
100* aminoglycoside antibiotic metabolic process (GO:0030647)11.0240410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.55152068
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.97995078
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.96717737
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.22580655
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.11291395
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.93203532
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.91618876
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.86298491
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.57354805
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05494265
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.03706364
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00678890
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.84992912
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74616873
15* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59140179
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46124456
17* ESR2_21235772_ChIP-Seq_MCF-7_Human2.42897068
18CLOCK_20551151_ChIP-Seq_293T_Human2.39507533
19ZNF263_19887448_ChIP-Seq_K562_Human2.00189794
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96512553
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.91539785
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.89351760
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80546917
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80453498
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71923711
26SOX2_20726797_ChIP-Seq_SW620_Human1.69351569
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.63529461
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61249336
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.57892166
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52715969
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52640855
32GATA4_25053715_ChIP-Seq_YYC3_Human1.52402621
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.50798689
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50556852
35* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43861030
36* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43861030
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38870454
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38870454
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37868327
40* CJUN_26792858_Chip-Seq_BT549_Human1.36326204
41GATA6_25053715_ChIP-Seq_YYC3_Human1.34540502
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32477159
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32315857
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32289282
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29523550
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26230569
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22796484
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17261893
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.15861826
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.12734371
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12443251
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10909094
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09136745
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08182750
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03846834
56RACK7_27058665_Chip-Seq_MCF-7_Human1.03521693
57PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02181102
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01963019
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00618147
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00214047
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99624595
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99220114
63SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98367235
64HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95888923
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94849153
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93018968
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92306637
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91372995
69AHR_22903824_ChIP-Seq_MCF-7_Human0.91104835
70TBX20_22080862_ChIP-Seq_HEART_Mouse0.90088943
71TBX20_22328084_ChIP-Seq_HEART_Mouse0.90088943
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89542195
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89482956
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.89460341
75TCF4_18268006_ChIP-ChIP_LS174T_Human0.88937242
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88909905
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86371204
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85636828
79EOMES_21245162_ChIP-Seq_HESCs_Human0.84898020
80TP53_18474530_ChIP-ChIP_U2OS_Human0.84209510
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84024316
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83225077
83LXR_22292898_ChIP-Seq_THP-1_Human0.81894993
84ATF3_27146783_Chip-Seq_COLON_Human0.78774655
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77996817
86PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77904161
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76966496
88FOXA1_25552417_ChIP-Seq_VCAP_Human0.76835359
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75894989
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75852089
91AR_21909140_ChIP-Seq_LNCAP_Human0.74893702
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.74608028
93* CBP_21632823_ChIP-Seq_H3396_Human0.74163869
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72418220
95SMC4_20622854_ChIP-Seq_HELA_Human0.71781819
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.70666259
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.70258434
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70069186
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69077414
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68992823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.60439635
2MP0005365_abnormal_bile_salt5.26884594
3MP0008875_abnormal_xenobiotic_pharmacok5.23087429
4MP0005085_abnormal_gallbladder_physiolo4.29048575
5MP0005360_urolithiasis3.70366563
6MP0005670_abnormal_white_adipose3.42585774
7MP0003868_abnormal_feces_composition3.42234772
8MP0003252_abnormal_bile_duct3.01940181
9MP0010329_abnormal_lipoprotein_level2.86269011
10MP0001666_abnormal_nutrient_absorption2.81259040
11MP0003195_calcinosis2.62010164
12MP0005666_abnormal_adipose_tissue2.34717289
13MP0003806_abnormal_nucleotide_metabolis2.34669077
14MP0002876_abnormal_thyroid_physiology2.25867478
15MP0002138_abnormal_hepatobiliary_system2.18653448
16MP0003186_abnormal_redox_activity2.11006541
17MP0005332_abnormal_amino_acid1.96935952
18MP0009840_abnormal_foam_cell1.95765461
19MP0002971_abnormal_brown_adipose1.93671964
20MP0002118_abnormal_lipid_homeostasis1.90875823
21MP0004019_abnormal_vitamin_homeostasis1.81249258
22MP0005375_adipose_tissue_phenotype1.75662435
23MP0004130_abnormal_muscle_cell1.74289334
24MP0000609_abnormal_liver_physiology1.70729757
25MP0001661_extended_life_span1.69339108
26MP0004185_abnormal_adipocyte_glucose1.68579049
27MP0003191_abnormal_cellular_cholesterol1.57370905
28MP0009780_abnormal_chondrocyte_physiolo1.46813116
29MP0003959_abnormal_lean_body1.31522421
30MP0003705_abnormal_hypodermis_morpholog1.31358527
31MP0003011_delayed_dark_adaptation1.29039621
32MP0008438_abnormal_cutaneous_collagen1.26974309
33MP0004272_abnormal_basement_membrane1.26396048
34MP0003950_abnormal_plasma_membrane1.24910745
35MP0005584_abnormal_enzyme/coenzyme_acti1.23701751
36MP0005319_abnormal_enzyme/_coenzyme1.22138833
37MP0000003_abnormal_adipose_tissue1.20152130
38MP0001764_abnormal_homeostasis1.19554208
39MP0002970_abnormal_white_adipose1.18864457
40MP0009643_abnormal_urine_homeostasis1.18704961
41MP0005164_abnormal_response_to1.16216703
42MP0005334_abnormal_fat_pad1.15001929
43MP0005408_hypopigmentation1.10711029
44MP0009115_abnormal_fat_cell1.06075361
45MP0003566_abnormal_cell_adhesion1.04312084
46MP0009697_abnormal_copulation1.04219574
47MP0005023_abnormal_wound_healing1.02135743
48MP0005248_abnormal_Harderian_gland0.97973205
49MP0005275_abnormal_skin_tensile0.94430770
50MP0009053_abnormal_anal_canal0.94154359
51MP0005451_abnormal_body_composition0.91082582
52MP0005503_abnormal_tendon_morphology0.89616799
53MP0006138_congestive_heart_failure0.88721130
54MP0000467_abnormal_esophagus_morphology0.88115057
55MP0002909_abnormal_adrenal_gland0.87598839
56MP0005376_homeostasis/metabolism_phenot0.85716666
57MP0006036_abnormal_mitochondrial_physio0.85410816
58MP0000013_abnormal_adipose_tissue0.84997107
59MP0002796_impaired_skin_barrier0.83936727
60MP0003690_abnormal_glial_cell0.81514958
61MP0000598_abnormal_liver_morphology0.80088540
62MP0005535_abnormal_body_temperature0.79931161
63MP0002078_abnormal_glucose_homeostasis0.78421145
64MP0005448_abnormal_energy_balance0.75138199
65MP0000858_altered_metastatic_potential0.71229661
66MP0003656_abnormal_erythrocyte_physiolo0.71007433
67MP0003453_abnormal_keratinocyte_physiol0.68986232
68MP0002060_abnormal_skin_morphology0.68576320
69MP0009642_abnormal_blood_homeostasis0.68291214
70MP0005058_abnormal_lysosome_morphology0.67856211
71MP0000751_myopathy0.67550173
72MP0004782_abnormal_surfactant_physiolog0.66259491
73MP0005636_abnormal_mineral_homeostasis0.65832591
74MP0001915_intracranial_hemorrhage0.65014710
75MP0009763_increased_sensitivity_to0.64528761
76MP0005266_abnormal_metabolism0.60943481
77MP0005452_abnormal_adipose_tissue0.60865367
78MP0010234_abnormal_vibrissa_follicle0.60103233
79MP0004883_abnormal_blood_vessel0.58700824
80MP0002108_abnormal_muscle_morphology0.58518433
81MP0000249_abnormal_blood_vessel0.57224851
82MP0002132_abnormal_respiratory_system0.57087914
83MP0005623_abnormal_meninges_morphology0.56585382
84MP0002295_abnormal_pulmonary_circulatio0.54905332
85MP0005083_abnormal_biliary_tract0.54866390
86MP0000604_amyloidosis0.53972494
87MP0003828_pulmonary_edema0.53299349
88MP0000762_abnormal_tongue_morphology0.53029169
89MP0000566_synostosis0.52656023
90MP0005165_increased_susceptibility_to0.50146231
91MP0001881_abnormal_mammary_gland0.49915599
92MP0003953_abnormal_hormone_level0.49367306
93MP0003091_abnormal_cell_migration0.48729912
94MP0005647_abnormal_sex_gland0.47694007
95MP0008469_abnormal_protein_level0.46669123
96MP0002168_other_aberrant_phenotype0.46258488
97MP0004233_abnormal_muscle_weight0.46214481
98MP0003879_abnormal_hair_cell0.45818711
99MP0002136_abnormal_kidney_physiology0.45504293
100MP0008775_abnormal_heart_ventricle0.44933385

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.35349267
2Deep venous thrombosis (HP:0002625)6.93372760
3Conjugated hyperbilirubinemia (HP:0002908)6.18015218
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16942418
5Complement deficiency (HP:0004431)5.99094373
6Hypobetalipoproteinemia (HP:0003563)5.87290906
7Prolonged partial thromboplastin time (HP:0003645)5.31392852
8Abnormality of complement system (HP:0005339)5.20694083
9Fat malabsorption (HP:0002630)4.60432827
10Steatorrhea (HP:0002570)4.56381103
11Systemic lupus erythematosus (HP:0002725)4.25414048
12Abnormality of the common coagulation pathway (HP:0010990)4.17429427
13Xanthomatosis (HP:0000991)3.98274891
14Vascular calcification (HP:0004934)3.92066999
15Glomerulonephritis (HP:0000099)3.89353300
16Hypolipoproteinemia (HP:0010981)3.82001446
17Hyperlipoproteinemia (HP:0010980)3.79792778
18Intrahepatic cholestasis (HP:0001406)3.70857310
19Joint hemorrhage (HP:0005261)3.67768038
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66304822
21Cardiovascular calcification (HP:0011915)3.62074874
22Mitral stenosis (HP:0001718)3.56240255
23Rickets (HP:0002748)3.51325745
24Hemorrhage of the eye (HP:0011885)3.47011917
25Back pain (HP:0003418)3.43046147
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.40511782
27Spontaneous abortion (HP:0005268)3.35261791
28Hypercholesterolemia (HP:0003124)3.29973787
29Nephritis (HP:0000123)3.28752965
30Vertebral compression fractures (HP:0002953)3.15272485
31Hydroxyprolinuria (HP:0003080)2.88667474
32Abnormality of proline metabolism (HP:0010907)2.88667474
33Acanthosis nigricans (HP:0000956)2.88266858
34Abnormality of the Achilles tendon (HP:0005109)2.88039820
35Hypertriglyceridemia (HP:0002155)2.78404565
36Abnormality of the intrinsic pathway (HP:0010989)2.76916712
37Protrusio acetabuli (HP:0003179)2.75802938
38Hyperammonemia (HP:0001987)2.71788243
39Epidermoid cyst (HP:0200040)2.69358439
40Generalized aminoaciduria (HP:0002909)2.65697328
41Hypoalphalipoproteinemia (HP:0003233)2.50172851
42Reduced antithrombin III activity (HP:0001976)2.45696785
43Myocardial infarction (HP:0001658)2.43816060
44Tetraparesis (HP:0002273)2.40680967
45Abnormality of pyrimidine metabolism (HP:0004353)2.37994918
46Skin nodule (HP:0200036)2.36367185
47Oligomenorrhea (HP:0000876)2.34303544
48Hyperbilirubinemia (HP:0002904)2.31875054
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22139065
50Abnormality of vitamin metabolism (HP:0100508)2.13165327
51Abnormality of glycolysis (HP:0004366)2.12034841
52Increased serum pyruvate (HP:0003542)2.11331606
53Arthropathy (HP:0003040)2.10001245
54Rhinitis (HP:0012384)2.07721083
55Amyloidosis (HP:0011034)2.07442802
56Bifid scrotum (HP:0000048)2.06777984
57Abnormality of carpal bone ossification (HP:0006257)1.95843300
58Hepatocellular carcinoma (HP:0001402)1.94916677
59Osteomalacia (HP:0002749)1.93645401
60Gingival bleeding (HP:0000225)1.91170756
61Glomerulosclerosis (HP:0000096)1.90642469
62Increased serum ferritin (HP:0003281)1.89915616
63Abnormal delivery (HP:0001787)1.88420881
64Focal segmental glomerulosclerosis (HP:0000097)1.88012246
65Short nail (HP:0001799)1.86283731
66Abnormality of methionine metabolism (HP:0010901)1.85956832
67Abnormality of fatty-acid metabolism (HP:0004359)1.84614738
68Abnormal cartilage morphology (HP:0002763)1.84365021
69Vascular tortuosity (HP:0004948)1.78261744
70Abnormal respiratory epithelium morphology (HP:0012253)1.78219657
71Abnormal respiratory motile cilium morphology (HP:0005938)1.78219657
72Insulin resistance (HP:0000855)1.77892781
73Achilles tendon contracture (HP:0001771)1.76409589
74Abnormal respiratory motile cilium physiology (HP:0012261)1.76277553
75Hypophosphatemic rickets (HP:0004912)1.75937290
76Arterial tortuosity (HP:0005116)1.74018899
77Polycythemia (HP:0001901)1.72296493
78Abnormality of nucleobase metabolism (HP:0010932)1.72233629
79Abnormality of iron homeostasis (HP:0011031)1.69607151
80Mucopolysacchariduria (HP:0008155)1.65400757
81Urinary glycosaminoglycan excretion (HP:0003541)1.65400757
82Abnormality of serum amino acid levels (HP:0003112)1.65060593
83Hyperglycinemia (HP:0002154)1.64471496
84Paraparesis (HP:0002385)1.61758091
85Purpura (HP:0000979)1.61432474
86Abnormal ciliary motility (HP:0012262)1.59926559
87Increased connective tissue (HP:0009025)1.58596229
88Hypoglycemic coma (HP:0001325)1.58470545
89Neonatal onset (HP:0003623)1.58028004
90Nausea (HP:0002018)1.57989939
91Cerebral palsy (HP:0100021)1.57917087
92Osteolytic defects of the phalanges of the hand (HP:0009771)1.57462118
93Osteolytic defects of the hand bones (HP:0009699)1.57462118
94Abnormality of urine glucose concentration (HP:0011016)1.56536462
95Glycosuria (HP:0003076)1.56536462
96Proximal tubulopathy (HP:0000114)1.54792988
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.54422665
98Elevated alkaline phosphatase (HP:0003155)1.54015506
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.52619313
100Absent/shortened dynein arms (HP:0200106)1.52619313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.55053898
2MST1R4.34166988
3TESK13.36596103
4IRAK33.25559692
5ERBB42.95063624
6EPHA22.69880476
7TRIB32.66980751
8LATS22.37231122
9RIPK12.27850486
10MET2.25373256
11SIK12.20547647
12MAPKAPK32.10743496
13DDR22.06290153
14FGFR42.04722581
15ARAF2.02778222
16PDGFRA1.78940892
17MAP3K121.77864908
18ABL21.67441472
19EPHA31.57867700
20EPHB21.55315228
21LIMK11.53248337
22MYLK1.51998311
23PRKAA21.50590436
24EIF2AK11.48733844
25MAP3K31.45883744
26MAP3K21.42828559
27SCYL21.39212944
28TBK11.38979232
29MAPK151.36084774
30LATS11.31389418
31ICK1.31272882
32PBK1.15872950
33LMTK21.15122064
34TGFBR21.13797428
35STK381.03871192
36MAP3K91.02179184
37TRPM71.00627082
38PAK40.99807117
39PTK20.99064979
40TTN0.98939686
41NEK90.95521746
42EPHB10.94077951
43MAPK110.93656701
44NME20.86709933
45RPS6KB20.86369144
46PDK20.82082594
47CAMK2G0.81958479
48PDPK10.81567775
49FER0.74613634
50CDK80.72826858
51MAP2K40.72677112
52CDK90.70993484
53PIK3CG0.69686743
54PRKACG0.69168931
55FGFR30.69113982
56ILK0.68686236
57PIM20.68212040
58MAP2K10.68052947
59PRKAA10.66927629
60PRPF4B0.64573348
61MAP3K10.61710504
62STK38L0.60330335
63NTRK10.59952814
64CDC42BPA0.58774525
65IGF1R0.57155697
66MAP3K60.56326193
67MAP3K130.54507745
68PIK3CA0.51836801
69MAPKAPK50.50849838
70CAMK1D0.50759753
71MTOR0.49175819
72CAMK2B0.48901504
73PRKG20.48795967
74PHKG20.48687671
75PHKG10.48687671
76GSK3A0.48646236
77PINK10.48203219
78AKT20.46726752
79PDGFRB0.46371006
80MAPK40.44659326
81PRKCE0.43984786
82EEF2K0.43757577
83CAMKK20.42597723
84KSR20.41280105
85TYK20.37817308
86ERBB30.37283019
87MAP3K70.36048887
88CDK60.35519070
89MAPK120.32939823
90LRRK20.32479305
91NEK10.31405373
92PAK20.30944380
93MELK0.30729611
94DAPK30.30711315
95CAMK10.30672443
96BMX0.30008265
97SRC0.29933149
98GRK50.28792165
99PRKCD0.27876291
100IRAK10.27710493

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.35938743
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.85631830
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.49365619
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.31695659
5Phenylalanine metabolism_Homo sapiens_hsa003603.20252596
6Retinol metabolism_Homo sapiens_hsa008303.17244727
7* Chemical carcinogenesis_Homo sapiens_hsa052043.02824163
8* Steroid hormone biosynthesis_Homo sapiens_hsa001403.00483555
9Caffeine metabolism_Homo sapiens_hsa002322.76783679
10Drug metabolism - other enzymes_Homo sapiens_hsa009832.66116825
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.65286447
12Complement and coagulation cascades_Homo sapiens_hsa046102.59683547
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.57758756
14Tyrosine metabolism_Homo sapiens_hsa003502.43161999
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33652209
16Histidine metabolism_Homo sapiens_hsa003402.29676668
17Fatty acid degradation_Homo sapiens_hsa000712.14537973
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.12866676
19Starch and sucrose metabolism_Homo sapiens_hsa005002.02894695
20PPAR signaling pathway_Homo sapiens_hsa033201.92809119
21beta-Alanine metabolism_Homo sapiens_hsa004101.84633554
22Arginine biosynthesis_Homo sapiens_hsa002201.79257270
23Tryptophan metabolism_Homo sapiens_hsa003801.62070965
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58595763
25Pyruvate metabolism_Homo sapiens_hsa006201.54409140
26Vitamin B6 metabolism_Homo sapiens_hsa007501.53415253
27Bile secretion_Homo sapiens_hsa049761.52937613
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49385530
29Glycerolipid metabolism_Homo sapiens_hsa005611.38129866
30Butanoate metabolism_Homo sapiens_hsa006501.35066548
31Glutathione metabolism_Homo sapiens_hsa004801.33412634
32Fat digestion and absorption_Homo sapiens_hsa049751.31434873
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26395721
34Fatty acid metabolism_Homo sapiens_hsa012121.23320595
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18526420
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.15664455
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12815271
38Carbon metabolism_Homo sapiens_hsa012001.07328424
39Peroxisome_Homo sapiens_hsa041461.05334850
40Fructose and mannose metabolism_Homo sapiens_hsa000511.04789162
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04563936
42Arachidonic acid metabolism_Homo sapiens_hsa005901.02858636
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99468738
44Pentose phosphate pathway_Homo sapiens_hsa000300.99393435
45Arginine and proline metabolism_Homo sapiens_hsa003300.95853874
46Galactose metabolism_Homo sapiens_hsa000520.95066338
47Propanoate metabolism_Homo sapiens_hsa006400.92203581
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.92179668
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89816151
50Linoleic acid metabolism_Homo sapiens_hsa005910.87534694
51Biosynthesis of amino acids_Homo sapiens_hsa012300.86530704
52Sulfur metabolism_Homo sapiens_hsa009200.81776863
53ABC transporters_Homo sapiens_hsa020100.79712400
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77582883
55Fatty acid biosynthesis_Homo sapiens_hsa000610.73144700
56Fatty acid elongation_Homo sapiens_hsa000620.69556112
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67116295
58Steroid biosynthesis_Homo sapiens_hsa001000.59271710
59Sulfur relay system_Homo sapiens_hsa041220.52902233
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.47155298
61Vitamin digestion and absorption_Homo sapiens_hsa049770.46736803
62Metabolic pathways_Homo sapiens_hsa011000.44935704
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.44421850
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43971377
65Folate biosynthesis_Homo sapiens_hsa007900.43907678
66Staphylococcus aureus infection_Homo sapiens_hsa051500.39893675
67Prion diseases_Homo sapiens_hsa050200.38088000
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37084684
69Lysine degradation_Homo sapiens_hsa003100.36511141
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35386485
71Ovarian steroidogenesis_Homo sapiens_hsa049130.33076645
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.31852917
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31534084
74One carbon pool by folate_Homo sapiens_hsa006700.30987975
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28269460
76AMPK signaling pathway_Homo sapiens_hsa041520.28199913
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27614981
78ECM-receptor interaction_Homo sapiens_hsa045120.25832417
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23918665
80Selenocompound metabolism_Homo sapiens_hsa004500.22887766
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19689109
82Protein digestion and absorption_Homo sapiens_hsa049740.19598438
83Insulin resistance_Homo sapiens_hsa049310.18333000
84Renin-angiotensin system_Homo sapiens_hsa046140.17861204
85Pancreatic secretion_Homo sapiens_hsa049720.17698152
86Other glycan degradation_Homo sapiens_hsa005110.15007998
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12543030
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.07752084
89Mineral absorption_Homo sapiens_hsa049780.05800034
90Sphingolipid metabolism_Homo sapiens_hsa006000.03899413
91Insulin signaling pathway_Homo sapiens_hsa049100.02458283
92N-Glycan biosynthesis_Homo sapiens_hsa005100.01088647
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0768597
94Nitrogen metabolism_Homo sapiens_hsa00910-0.0716432
95Amoebiasis_Homo sapiens_hsa05146-0.0686201
96Focal adhesion_Homo sapiens_hsa04510-0.0663455
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0403304
98Glucagon signaling pathway_Homo sapiens_hsa04922-0.0330597
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0035344
100Pertussis_Homo sapiens_hsa05133-0.0031302

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »