AKR1C3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* polyketide metabolic process (GO:0030638)9.92963378
2* doxorubicin metabolic process (GO:0044598)9.92963378
3* daunorubicin metabolic process (GO:0044597)9.92963378
4* aminoglycoside antibiotic metabolic process (GO:0030647)8.68270463
5cellular glucuronidation (GO:0052695)6.56027957
6glucuronate metabolic process (GO:0019585)6.36969373
7uronic acid metabolic process (GO:0006063)6.36969373
8ethanol oxidation (GO:0006069)5.69155414
9* primary alcohol catabolic process (GO:0034310)5.45516493
10* glycoside metabolic process (GO:0016137)5.30182466
11intestinal cholesterol absorption (GO:0030299)5.29614721
12intestinal absorption (GO:0050892)5.04068583
13L-phenylalanine metabolic process (GO:0006558)4.94426094
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94426094
15ethanol metabolic process (GO:0006067)4.88385828
16flavonoid metabolic process (GO:0009812)4.88175551
17urea metabolic process (GO:0019627)4.85139781
18epoxygenase P450 pathway (GO:0019373)4.77920293
19regulation of protein activation cascade (GO:2000257)4.73955087
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62928446
21L-phenylalanine catabolic process (GO:0006559)4.62928446
22urea cycle (GO:0000050)4.56479827
23negative regulation of fibrinolysis (GO:0051918)4.55411697
24regulation of complement activation (GO:0030449)4.52069779
25nitrogen cycle metabolic process (GO:0071941)4.50645513
26very-low-density lipoprotein particle assembly (GO:0034379)4.46283974
27complement activation, alternative pathway (GO:0006957)4.43182909
28bile acid metabolic process (GO:0008206)4.40443986
29bile acid and bile salt transport (GO:0015721)4.39492000
30drug catabolic process (GO:0042737)4.35170453
31drug metabolic process (GO:0017144)4.32247185
32exogenous drug catabolic process (GO:0042738)4.25518312
33regulation of cholesterol esterification (GO:0010872)4.24016646
34regulation of triglyceride catabolic process (GO:0010896)4.23637145
35regulation of fibrinolysis (GO:0051917)4.22564880
36* quinone metabolic process (GO:1901661)3.93499289
37positive regulation of triglyceride lipase activity (GO:0061365)3.91160714
38positive regulation of lipoprotein lipase activity (GO:0051006)3.91160714
39* progesterone metabolic process (GO:0042448)3.90700996
40NADH metabolic process (GO:0006734)3.82891915
41angiotensin maturation (GO:0002003)3.79918790
42protein carboxylation (GO:0018214)3.79217690
43peptidyl-glutamic acid carboxylation (GO:0017187)3.79217690
44regulation of bile acid biosynthetic process (GO:0070857)3.76814085
45drug transmembrane transport (GO:0006855)3.75569354
46* primary alcohol metabolic process (GO:0034308)3.75515515
47phenylpropanoid metabolic process (GO:0009698)3.74520522
48hormone catabolic process (GO:0042447)3.72474583
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.69142298
50protein-lipid complex remodeling (GO:0034368)3.62284994
51macromolecular complex remodeling (GO:0034367)3.62284994
52plasma lipoprotein particle remodeling (GO:0034369)3.62284994
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.60372092
54fibrinolysis (GO:0042730)3.60107177
55plasma lipoprotein particle assembly (GO:0034377)3.58946060
56glyoxylate metabolic process (GO:0046487)3.52429697
57phospholipid efflux (GO:0033700)3.48630351
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44949690
59acute-phase response (GO:0006953)3.40017402
60negative regulation of hemostasis (GO:1900047)3.37388078
61negative regulation of blood coagulation (GO:0030195)3.37388078
62high-density lipoprotein particle remodeling (GO:0034375)3.32248239
63protein-lipid complex assembly (GO:0065005)3.29680975
64negative regulation of sterol transport (GO:0032372)3.29654010
65negative regulation of cholesterol transport (GO:0032375)3.29654010
66L-ascorbic acid metabolic process (GO:0019852)3.29326342
67* cellular aldehyde metabolic process (GO:0006081)3.28769121
68negative regulation of coagulation (GO:0050819)3.28578596
69plasma lipoprotein particle clearance (GO:0034381)3.26984556
70blood coagulation, intrinsic pathway (GO:0007597)3.25802490
71diacylglycerol metabolic process (GO:0046339)3.25403207
72omega-hydroxylase P450 pathway (GO:0097267)3.23390766
73alpha-linolenic acid metabolic process (GO:0036109)3.23285324
74complement activation, classical pathway (GO:0006958)3.23001440
75cholesterol efflux (GO:0033344)3.22539708
76drug transport (GO:0015893)3.22279200
77acylglycerol homeostasis (GO:0055090)3.19160654
78triglyceride homeostasis (GO:0070328)3.19160654
79regulation of plasminogen activation (GO:0010755)3.18916072
80digestion (GO:0007586)3.16551964
81fat-soluble vitamin biosynthetic process (GO:0042362)3.16457691
82positive regulation of lipid catabolic process (GO:0050996)3.15774334
83cholesterol homeostasis (GO:0042632)3.15747809
84bile acid biosynthetic process (GO:0006699)3.14264288
85positive regulation of fatty acid biosynthetic process (GO:0045723)3.14053596
86negative regulation of protein activation cascade (GO:2000258)3.13201693
87low-density lipoprotein particle clearance (GO:0034383)3.10357931
88sterol homeostasis (GO:0055092)3.10328407
89protein activation cascade (GO:0072376)3.10264726
90xenobiotic catabolic process (GO:0042178)3.07209503
91triglyceride catabolic process (GO:0019433)3.06778191
92plasma lipoprotein particle organization (GO:0071827)3.06323121
93negative regulation of wound healing (GO:0061045)3.05418957
94xenobiotic metabolic process (GO:0006805)3.04886561
95low-density lipoprotein particle remodeling (GO:0034374)3.04175392
96arginine metabolic process (GO:0006525)3.03790934
97lipoprotein metabolic process (GO:0042157)3.02182135
98negative regulation of lipase activity (GO:0060192)3.00643721
99lipoprotein transport (GO:0042953)3.00305103
100acylglycerol catabolic process (GO:0046464)2.99554867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.39103322
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.84514691
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.75876910
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.16021719
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.00596192
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.82420502
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.30897344
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.10819515
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.95739247
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.76281810
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69438526
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66359901
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.65251516
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58000848
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.36148076
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.34944163
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26067075
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23856798
19ZNF263_19887448_ChIP-Seq_K562_Human2.19255112
20GATA4_25053715_ChIP-Seq_YYC3_Human2.17841266
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.17242660
22SOX2_20726797_ChIP-Seq_SW620_Human2.14120465
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.07852632
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06613731
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05424925
26CLOCK_20551151_ChIP-Seq_293T_Human2.04130455
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.92983915
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.92688333
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.85928818
30* GATA6_25053715_ChIP-Seq_YYC3_Human1.82567789
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78828239
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76589608
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75900858
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.75391558
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.73509520
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61712804
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52083011
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46689672
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40461302
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40419974
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.39883270
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37069108
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.35669511
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31814738
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30746726
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.29839878
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29415840
48* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24966241
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14583500
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14464997
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14464997
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10798922
53LXR_22292898_ChIP-Seq_THP-1_Human1.10585253
54RACK7_27058665_Chip-Seq_MCF-7_Human1.09688342
55* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09211416
56GATA3_24758297_ChIP-Seq_MCF-7_Human1.07681489
57CJUN_26792858_Chip-Seq_BT549_Human1.05602648
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02851434
59AR_21909140_ChIP-Seq_LNCAP_Human1.02448312
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01830553
61* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99656702
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97883987
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96126338
64ESR1_20079471_ChIP-ChIP_T-47D_Human0.94829550
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92420098
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91240742
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90525926
68ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89929553
69SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89589758
70FOXA1_25552417_ChIP-Seq_VCAP_Human0.88897311
71HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88096662
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87463898
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87461453
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.86237693
75CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84619571
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84531002
77CEBPB_22108803_ChIP-Seq_LS180_Human0.84045710
78GATA1_22025678_ChIP-Seq_K562_Human0.82930223
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82403232
80ATF3_27146783_Chip-Seq_COLON_Human0.80988722
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79774227
82ELK3_25401928_ChIP-Seq_HUVEC_Human0.79538581
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78581472
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78148432
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76919891
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76919891
87TET1_21451524_ChIP-Seq_MESCs_Mouse0.76032619
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74887549
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73974125
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72660086
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72047065
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71791041
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71551664
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71143858
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70504501
96BCOR_27268052_Chip-Seq_Bcells_Human0.70089184
97CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70037325
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69938837
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69765248
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69056053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.03742318
2MP0005360_urolithiasis6.13955833
3MP0005365_abnormal_bile_salt5.11416649
4MP0005085_abnormal_gallbladder_physiolo4.83428768
5MP0001666_abnormal_nutrient_absorption4.03082936
6MP0008875_abnormal_xenobiotic_pharmacok3.80000507
7MP0003868_abnormal_feces_composition3.20519864
8MP0003252_abnormal_bile_duct2.99896307
9MP0003806_abnormal_nucleotide_metabolis2.77973240
10MP0009840_abnormal_foam_cell2.70736627
11MP0010329_abnormal_lipoprotein_level2.67895917
12MP0005670_abnormal_white_adipose2.59464973
13MP0002138_abnormal_hepatobiliary_system2.54829784
14MP0004019_abnormal_vitamin_homeostasis2.29805428
15MP0003195_calcinosis2.16873548
16MP0005332_abnormal_amino_acid2.15498316
17MP0003191_abnormal_cellular_cholesterol2.01952375
18MP0002876_abnormal_thyroid_physiology1.96787328
19MP0002118_abnormal_lipid_homeostasis1.76413669
20MP0000609_abnormal_liver_physiology1.66871546
21MP0009643_abnormal_urine_homeostasis1.60116544
22MP0001764_abnormal_homeostasis1.53644651
23MP0005666_abnormal_adipose_tissue1.46435812
24MP0002971_abnormal_brown_adipose1.39733511
25MP0003186_abnormal_redox_activity1.36892810
26MP0005319_abnormal_enzyme/_coenzyme1.35228905
27MP0003183_abnormal_peptide_metabolism1.31099653
28MP0010234_abnormal_vibrissa_follicle1.29788353
29MP0009697_abnormal_copulation1.22416776
30MP0005584_abnormal_enzyme/coenzyme_acti1.20307225
31MP0005058_abnormal_lysosome_morphology1.18544633
32MP0010155_abnormal_intestine_physiology1.10037773
33MP0002132_abnormal_respiratory_system1.09698821
34MP0005636_abnormal_mineral_homeostasis1.08475845
35MP0005375_adipose_tissue_phenotype1.04929092
36MP0004147_increased_porphyrin_level1.02777938
37MP0005451_abnormal_body_composition1.01481241
38MP0005165_increased_susceptibility_to0.98266943
39MP0009780_abnormal_chondrocyte_physiolo0.96196094
40MP0004782_abnormal_surfactant_physiolog0.95436139
41MP0001661_extended_life_span0.93482567
42MP0005464_abnormal_platelet_physiology0.92396808
43MP0003656_abnormal_erythrocyte_physiolo0.91787983
44MP0000598_abnormal_liver_morphology0.91559798
45MP0005164_abnormal_response_to0.90942902
46MP0001664_abnormal_digestion0.90799956
47MP0005023_abnormal_wound_healing0.89938475
48MP0008469_abnormal_protein_level0.88807286
49MP0004272_abnormal_basement_membrane0.86092194
50MP0000013_abnormal_adipose_tissue0.85406979
51MP0008438_abnormal_cutaneous_collagen0.85366847
52MP0003300_gastrointestinal_ulcer0.84448765
53MP0005408_hypopigmentation0.84371701
54MP0004264_abnormal_extraembryonic_tissu0.84242917
55MP0005334_abnormal_fat_pad0.83923940
56MP0009642_abnormal_blood_homeostasis0.82789081
57MP0004185_abnormal_adipocyte_glucose0.82681146
58MP0002136_abnormal_kidney_physiology0.82467699
59MP0003950_abnormal_plasma_membrane0.81804562
60MP0000003_abnormal_adipose_tissue0.80889020
61MP0001881_abnormal_mammary_gland0.80341795
62MP0009115_abnormal_fat_cell0.80057981
63MP0005166_decreased_susceptibility_to0.79577377
64MP0009379_abnormal_foot_pigmentation0.79384317
65MP0003959_abnormal_lean_body0.78639441
66MP0005376_homeostasis/metabolism_phenot0.78405563
67MP0006036_abnormal_mitochondrial_physio0.78262515
68MP0000604_amyloidosis0.77987513
69MP0001756_abnormal_urination0.77193823
70MP0003075_altered_response_to0.76395874
71MP0005535_abnormal_body_temperature0.75912393
72MP0002970_abnormal_white_adipose0.75751072
73MP0005409_darkened_coat_color0.75167200
74MP0005448_abnormal_energy_balance0.71088531
75MP0000858_altered_metastatic_potential0.70784028
76MP0003718_maternal_effect0.69556033
77MP0002078_abnormal_glucose_homeostasis0.67718746
78MP0009763_increased_sensitivity_to0.66611405
79MP0003866_abnormal_defecation0.65883529
80MP0000249_abnormal_blood_vessel0.65665067
81MP0000477_abnormal_intestine_morphology0.62805741
82MP0006138_congestive_heart_failure0.61777370
83MP0008260_abnormal_autophagy0.60662512
84MP0001873_stomach_inflammation0.59651339
85MP0005395_other_phenotype0.58697969
86MP0003566_abnormal_cell_adhesion0.58680363
87MP0010386_abnormal_urinary_bladder0.57689869
88MP0002796_impaired_skin_barrier0.56638247
89MP0004043_abnormal_pH_regulation0.56255961
90MP0005083_abnormal_biliary_tract0.54739188
91MP0000467_abnormal_esophagus_morphology0.54647198
92MP0010352_gastrointestinal_tract_polyps0.54575971
93MP0001845_abnormal_inflammatory_respons0.52973991
94MP0001663_abnormal_digestive_system0.52743419
95MP0008775_abnormal_heart_ventricle0.52650087
96MP0010368_abnormal_lymphatic_system0.52400206
97MP0001765_abnormal_ion_homeostasis0.51500332
98MP0003879_abnormal_hair_cell0.50259122
99MP0000490_abnormal_crypts_of0.49456686
100MP0005501_abnormal_skin_physiology0.49186034

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64897830
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.05980998
3Hypobetalipoproteinemia (HP:0003563)5.74147214
4Deep venous thrombosis (HP:0002625)5.69085399
5Complement deficiency (HP:0004431)5.56893158
6Conjugated hyperbilirubinemia (HP:0002908)5.02887694
7Fat malabsorption (HP:0002630)4.94840521
8Systemic lupus erythematosus (HP:0002725)4.92461747
9Abnormality of complement system (HP:0005339)4.84198231
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.64473345
11Abnormality of proline metabolism (HP:0010907)4.45985901
12Hydroxyprolinuria (HP:0003080)4.45985901
13Steatorrhea (HP:0002570)4.38006792
14Prolonged partial thromboplastin time (HP:0003645)4.24543738
15Xanthomatosis (HP:0000991)3.90589570
16Glomerulonephritis (HP:0000099)3.80163154
17Hypolipoproteinemia (HP:0010981)3.52283556
18Intrahepatic cholestasis (HP:0001406)3.47226643
19Abnormality of the common coagulation pathway (HP:0010990)3.43355215
20Hemorrhage of the eye (HP:0011885)3.42952366
21Hyperammonemia (HP:0001987)3.38083921
22Vascular calcification (HP:0004934)3.36941738
23Joint hemorrhage (HP:0005261)3.20871386
24Cardiovascular calcification (HP:0011915)3.09712217
25Nephritis (HP:0000123)3.03782748
26Malnutrition (HP:0004395)2.99833364
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93998882
28Vertebral compression fractures (HP:0002953)2.85424384
29Generalized aminoaciduria (HP:0002909)2.80963421
30Ileus (HP:0002595)2.71664689
31Hypercholesterolemia (HP:0003124)2.71180656
32Abnormality of pyrimidine metabolism (HP:0004353)2.69775254
33Hyperlipoproteinemia (HP:0010980)2.67369742
34Nausea (HP:0002018)2.65337946
35Spontaneous abortion (HP:0005268)2.62949617
36Acanthocytosis (HP:0001927)2.60713157
37Rickets (HP:0002748)2.57631342
38Cerebral palsy (HP:0100021)2.51459975
39Abnormality of vitamin metabolism (HP:0100508)2.45267630
40Abnormal sex determination (HP:0012244)2.45045507
41Sex reversal (HP:0012245)2.45045507
42Reduced antithrombin III activity (HP:0001976)2.43911172
43Abnormality of urine glucose concentration (HP:0011016)2.43185050
44Glycosuria (HP:0003076)2.43185050
45Abnormality of nucleobase metabolism (HP:0010932)2.33133561
46Abnormality of the intrinsic pathway (HP:0010989)2.32344428
47Proximal tubulopathy (HP:0000114)2.31711981
48Epidermoid cyst (HP:0200040)2.29563538
49Hyperbilirubinemia (HP:0002904)2.29159065
50Abnormality of fatty-acid metabolism (HP:0004359)2.28155772
51Tetraparesis (HP:0002273)2.26584134
52Hypertriglyceridemia (HP:0002155)2.25621569
53Amyloidosis (HP:0011034)2.25582096
54Mitral stenosis (HP:0001718)2.24473761
55Potter facies (HP:0002009)2.23934218
56Facial shape deformation (HP:0011334)2.23934218
57Focal segmental glomerulosclerosis (HP:0000097)2.21350758
58Hepatocellular carcinoma (HP:0001402)2.20697219
59Glomerulosclerosis (HP:0000096)2.20638523
60Mucopolysacchariduria (HP:0008155)2.19295267
61Urinary glycosaminoglycan excretion (HP:0003541)2.19295267
62Back pain (HP:0003418)2.17568777
63Abnormality of the Achilles tendon (HP:0005109)2.17283746
64Abnormality of purine metabolism (HP:0004352)2.16339451
65Rhabdomyolysis (HP:0003201)2.13630432
66Protrusio acetabuli (HP:0003179)2.08178801
67Abnormality of carpal bone ossification (HP:0006257)2.07737875
68Increased serum ferritin (HP:0003281)2.07303723
69Pancreatitis (HP:0001733)2.06527025
70Abnormal enzyme/coenzyme activity (HP:0012379)2.06298210
71Widely patent fontanelles and sutures (HP:0004492)2.06056682
72Gingival bleeding (HP:0000225)2.04786100
73Hyperglycinuria (HP:0003108)2.04319344
74Myocardial infarction (HP:0001658)2.03694933
75Pigmentary retinal degeneration (HP:0001146)2.02696393
76Dicarboxylic aciduria (HP:0003215)2.00666997
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00666997
78Abnormality of serine family amino acid metabolism (HP:0010894)2.00463563
79Abnormality of glycine metabolism (HP:0010895)2.00463563
80Abnormality of iron homeostasis (HP:0011031)2.00424694
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98652802
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98502425
83Hypoglycemic coma (HP:0001325)1.97769001
84Flat acetabular roof (HP:0003180)1.97679424
85Metabolic acidosis (HP:0001942)1.97481673
86Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96531231
87Abnormality of polysaccharide metabolism (HP:0011012)1.96531231
88Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96531231
89Hypoalphalipoproteinemia (HP:0003233)1.95905165
90Skin nodule (HP:0200036)1.95074175
91Purpura (HP:0000979)1.93508751
92Gout (HP:0001997)1.92406506
93Prolonged neonatal jaundice (HP:0006579)1.92167159
94Increased purine levels (HP:0004368)1.91238887
95Hyperuricemia (HP:0002149)1.91238887
96Alkalosis (HP:0001948)1.90709499
97Abnormality of alkaline phosphatase activity (HP:0004379)1.90374251
98Exocrine pancreatic insufficiency (HP:0001738)1.85812584
99Elevated alkaline phosphatase (HP:0003155)1.84261446
100Acanthosis nigricans (HP:0000956)1.84084231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.87477827
2MST1R5.12715688
3EPHA23.39453409
4LMTK23.14988215
5TESK12.66244724
6RIPK12.41290497
7MET2.30156886
8ACVR1B2.28567879
9SCYL22.28031432
10IRAK32.27926578
11FGFR42.25587129
12PBK1.95912615
13PRKG21.85805579
14DDR21.81922189
15NME21.81103718
16MAP3K121.80047186
17TBK11.72298796
18PDK21.67266986
19MAPKAPK31.64046957
20ERBB41.61257313
21NEK11.38002577
22ABL21.37237124
23TRIB31.29069557
24ARAF1.28909278
25PDGFRA1.27241282
26EIF2AK11.26602518
27MAPK111.23961549
28BCKDK1.22864735
29MAP3K21.19886180
30MYLK1.18164503
31MAP3K31.17317270
32TGFBR21.16093437
33PRKAA21.10545327
34PIM21.07193792
35TYK21.04935033
36TESK21.02729600
37PIK3CA1.00619538
38FLT30.99550334
39FGFR30.98419182
40CDK80.96164315
41LIMK10.95334455
42SIK10.93141186
43MST40.91051417
44PRPF4B0.90595697
45EPHB20.90211007
46TAOK30.88845639
47PAK40.84968311
48MAP3K130.84438909
49EPHA30.83903111
50MATK0.81280538
51DAPK10.80749011
52PDPK10.80691593
53MAP3K10.80588268
54RPS6KB20.77777451
55CDK90.76978069
56EIF2AK30.76174863
57LATS10.74234872
58STK390.74170052
59NEK90.71215771
60PTK20.68923710
61FER0.67061440
62CDC42BPA0.63625928
63PRKACG0.62303210
64MAP2K20.62155997
65PTK60.58150537
66ZAP700.56959145
67EPHB10.55625293
68TRPM70.53204856
69IGF1R0.52524711
70MELK0.51671805
71LATS20.51544583
72JAK30.50905668
73MAP3K110.49638235
74KIT0.47279069
75ICK0.46606321
76MAPKAPK50.46201899
77CAMK2G0.45577006
78PIK3CG0.45494477
79KDR0.43910405
80CSF1R0.43010622
81BMPR20.43000550
82BMX0.41923210
83SRC0.41378772
84STK160.40470998
85MAP2K10.39496031
86MAP3K60.38565571
87GRK60.38240648
88CDK60.38001557
89GSK3A0.34548014
90PDK10.33966964
91SMG10.33566324
92PRKCD0.33455373
93LRRK20.30616641
94MAP3K70.30085477
95PRKCA0.29395733
96STK380.27725913
97ILK0.26656738
98DAPK30.26176834
99CAMK2D0.26103305
100GRK50.25544237

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.89671236
2Pentose and glucuronate interconversions_Homo sapiens_hsa000403.68088695
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.01690927
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.99161656
5Chemical carcinogenesis_Homo sapiens_hsa052042.94331370
6Retinol metabolism_Homo sapiens_hsa008302.83855241
7* Steroid hormone biosynthesis_Homo sapiens_hsa001402.67816263
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.57438549
9Fat digestion and absorption_Homo sapiens_hsa049752.55671877
10Drug metabolism - other enzymes_Homo sapiens_hsa009832.55169191
11Complement and coagulation cascades_Homo sapiens_hsa046102.44467719
12Phenylalanine metabolism_Homo sapiens_hsa003602.43412005
13Caffeine metabolism_Homo sapiens_hsa002322.31245956
14Histidine metabolism_Homo sapiens_hsa003402.30453347
15Starch and sucrose metabolism_Homo sapiens_hsa005002.28168869
16Fatty acid degradation_Homo sapiens_hsa000712.26980142
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.17916371
18Arginine biosynthesis_Homo sapiens_hsa002202.17626743
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.17209833
20PPAR signaling pathway_Homo sapiens_hsa033201.89911248
21Tyrosine metabolism_Homo sapiens_hsa003501.84681637
22Vitamin digestion and absorption_Homo sapiens_hsa049771.81583971
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73073275
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65243443
25Bile secretion_Homo sapiens_hsa049761.64047199
26Fructose and mannose metabolism_Homo sapiens_hsa000511.63154417
27Tryptophan metabolism_Homo sapiens_hsa003801.60826006
28Galactose metabolism_Homo sapiens_hsa000521.54433379
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49431626
30Glycerolipid metabolism_Homo sapiens_hsa005611.48976637
31Sulfur metabolism_Homo sapiens_hsa009201.47412107
32Glutathione metabolism_Homo sapiens_hsa004801.43965837
33Renin-angiotensin system_Homo sapiens_hsa046141.42131179
34Fatty acid metabolism_Homo sapiens_hsa012121.37729418
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36894931
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36152236
37Pyruvate metabolism_Homo sapiens_hsa006201.32200532
38beta-Alanine metabolism_Homo sapiens_hsa004101.31485783
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29995953
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25487549
41Peroxisome_Homo sapiens_hsa041461.22671974
42Pentose phosphate pathway_Homo sapiens_hsa000301.17222078
43Arginine and proline metabolism_Homo sapiens_hsa003301.15635759
44Carbon metabolism_Homo sapiens_hsa012001.14904537
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13118589
46Linoleic acid metabolism_Homo sapiens_hsa005911.12418999
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09024597
48Butanoate metabolism_Homo sapiens_hsa006501.05629731
49* Arachidonic acid metabolism_Homo sapiens_hsa005901.04761230
50Protein digestion and absorption_Homo sapiens_hsa049741.03804139
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03674169
52Biosynthesis of amino acids_Homo sapiens_hsa012301.00159728
53Fatty acid elongation_Homo sapiens_hsa000620.99308424
54Propanoate metabolism_Homo sapiens_hsa006400.98401589
55Staphylococcus aureus infection_Homo sapiens_hsa051500.94683927
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.94258914
57Vitamin B6 metabolism_Homo sapiens_hsa007500.89051069
58Fatty acid biosynthesis_Homo sapiens_hsa000610.86760733
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76546153
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.76417110
61Mineral absorption_Homo sapiens_hsa049780.75848700
62ABC transporters_Homo sapiens_hsa020100.75655768
63Other glycan degradation_Homo sapiens_hsa005110.69079510
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.66781798
65Pancreatic secretion_Homo sapiens_hsa049720.66183781
66Sulfur relay system_Homo sapiens_hsa041220.64367649
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61883134
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55848030
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53481579
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48947235
71* Metabolic pathways_Homo sapiens_hsa011000.48562578
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44224166
73Folate biosynthesis_Homo sapiens_hsa007900.38933172
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31852740
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.31152335
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30036825
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29369767
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.27858876
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27635781
80Prion diseases_Homo sapiens_hsa050200.27297640
81N-Glycan biosynthesis_Homo sapiens_hsa005100.26546858
82Nitrogen metabolism_Homo sapiens_hsa009100.23849647
83Pertussis_Homo sapiens_hsa051330.21302544
84Sphingolipid metabolism_Homo sapiens_hsa006000.20774550
85Insulin resistance_Homo sapiens_hsa049310.15102742
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14371271
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10494456
88Thyroid hormone synthesis_Homo sapiens_hsa049180.10036153
89Ether lipid metabolism_Homo sapiens_hsa005650.09810164
90One carbon pool by folate_Homo sapiens_hsa006700.09706689
91Lysine degradation_Homo sapiens_hsa003100.09629291
92Steroid biosynthesis_Homo sapiens_hsa001000.08440118
93Selenocompound metabolism_Homo sapiens_hsa004500.00254322
94Amoebiasis_Homo sapiens_hsa05146-0.0781419
95Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0683911
96Lysosome_Homo sapiens_hsa04142-0.0626494
97ECM-receptor interaction_Homo sapiens_hsa04512-0.0567984
98Glucagon signaling pathway_Homo sapiens_hsa04922-0.0551242
99Hepatitis C_Homo sapiens_hsa05160-0.0502907
100AMPK signaling pathway_Homo sapiens_hsa04152-0.0065613

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