AKR1C5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)9.67220594
2drug catabolic process (GO:0042737)8.99797572
3omega-hydroxylase P450 pathway (GO:0097267)8.57986905
4regulation of protein activation cascade (GO:2000257)8.06204304
5epoxygenase P450 pathway (GO:0019373)7.79731159
6regulation of complement activation (GO:0030449)7.63553503
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.73409761
8L-phenylalanine catabolic process (GO:0006559)6.73409761
9regulation of triglyceride catabolic process (GO:0010896)6.45797952
10cellular glucuronidation (GO:0052695)6.17171760
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08383861
12L-phenylalanine metabolic process (GO:0006558)6.08383861
13negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.07444735
14glucuronate metabolic process (GO:0019585)5.87954350
15uronic acid metabolic process (GO:0006063)5.87954350
16regulation of fibrinolysis (GO:0051917)5.73830991
17negative regulation of fibrinolysis (GO:0051918)5.72837538
18blood coagulation, intrinsic pathway (GO:0007597)5.69137665
19peptidyl-glutamic acid carboxylation (GO:0017187)5.58206016
20protein carboxylation (GO:0018214)5.58206016
21urea metabolic process (GO:0019627)5.48135613
22opsonization (GO:0008228)5.46607050
23positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.32619150
24negative regulation of protein activation cascade (GO:2000258)5.26294747
25positive regulation of chemokine secretion (GO:0090197)5.23176366
26drug metabolic process (GO:0017144)5.18685650
27nerve growth factor signaling pathway (GO:0038180)5.17266550
28aromatic amino acid family catabolic process (GO:0009074)5.15282788
29polyketide metabolic process (GO:0030638)5.12108765
30doxorubicin metabolic process (GO:0044598)5.12108765
31daunorubicin metabolic process (GO:0044597)5.12108765
32protein activation cascade (GO:0072376)5.09182081
33cytolysis (GO:0019835)5.00783393
34nitrogen cycle metabolic process (GO:0071941)4.98240258
35bile acid biosynthetic process (GO:0006699)4.90936878
36regulation of humoral immune response (GO:0002920)4.88624737
37bile acid and bile salt transport (GO:0015721)4.83369146
38fibrinolysis (GO:0042730)4.76520504
39oxidative demethylation (GO:0070989)4.74754524
40complement activation (GO:0006956)4.70615249
41disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.52989475
42killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.52989475
43aminoglycoside antibiotic metabolic process (GO:0030647)4.52228430
44complement activation, classical pathway (GO:0006958)4.49683125
45regulation of chemokine secretion (GO:0090196)4.48067671
46imidazole-containing compound metabolic process (GO:0052803)4.47608922
47bile acid metabolic process (GO:0008206)4.42968857
48glyoxylate metabolic process (GO:0046487)4.41802923
49tyrosine metabolic process (GO:0006570)4.41163365
50acute-phase response (GO:0006953)4.37237639
51negative regulation of norepinephrine secretion (GO:0010700)4.34729100
52negative regulation of neurotransmitter secretion (GO:0046929)4.34518037
53negative regulation of hemostasis (GO:1900047)4.20719095
54negative regulation of blood coagulation (GO:0030195)4.20719095
55urea cycle (GO:0000050)4.16171210
56triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15165265
57S-adenosylmethionine metabolic process (GO:0046500)4.09532339
58positive regulation of vasculogenesis (GO:2001214)4.02963155
59positive regulation of blood coagulation (GO:0030194)3.90903294
60positive regulation of hemostasis (GO:1900048)3.90903294
61negative regulation of coagulation (GO:0050819)3.88847062
62negative regulation of complement activation (GO:0045916)3.85318527
63negative regulation of wound healing (GO:0061045)3.74934858
64tryptophan catabolic process (GO:0006569)3.74725479
65indole-containing compound catabolic process (GO:0042436)3.74725479
66indolalkylamine catabolic process (GO:0046218)3.74725479
67positive regulation of coagulation (GO:0050820)3.70469517
68positive regulation of macrophage activation (GO:0043032)3.67942203
69intestinal cholesterol absorption (GO:0030299)3.66240063
70flavonoid metabolic process (GO:0009812)3.58539687
71rRNA methylation (GO:0031167)3.56863619
72arginine catabolic process (GO:0006527)3.56697434
73serine family amino acid catabolic process (GO:0009071)3.49015453
74negative regulation of neurotransmitter transport (GO:0051589)3.44844411
75amine catabolic process (GO:0009310)3.44032606
76cellular biogenic amine catabolic process (GO:0042402)3.44032606
77regulation of acute inflammatory response (GO:0002673)3.38760089
78triglyceride homeostasis (GO:0070328)3.35038488
79acylglycerol homeostasis (GO:0055090)3.35038488
80thrombin receptor signaling pathway (GO:0070493)3.31723587
81Rap protein signal transduction (GO:0032486)3.30545254
82arginine metabolic process (GO:0006525)3.28147515
83hormone catabolic process (GO:0042447)3.24479911
84positive regulation of lipoprotein lipase activity (GO:0051006)3.24292373
85positive regulation of triglyceride lipase activity (GO:0061365)3.24292373
86aromatic amino acid family metabolic process (GO:0009072)3.23288382
87phenylpropanoid metabolic process (GO:0009698)3.22612539
88glycine metabolic process (GO:0006544)3.20596310
89acute inflammatory response (GO:0002526)3.19263796
90regulation of plasminogen activation (GO:0010755)3.18376008
91xenobiotic catabolic process (GO:0042178)3.16960577
92rRNA modification (GO:0000154)3.16960334
93positive regulation of triglyceride metabolic process (GO:0090208)3.14346835
94sodium-independent organic anion transport (GO:0043252)3.11741802
95negative regulation of cholesterol transport (GO:0032375)3.10945955
96negative regulation of sterol transport (GO:0032372)3.10945955
97regulation of blood coagulation (GO:0030193)3.10932961
98regulation of hemostasis (GO:1900046)3.10932961
99coenzyme catabolic process (GO:0009109)3.07174391
100exogenous drug catabolic process (GO:0042738)10.2676344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.24951410
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.09468069
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.02132168
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.73366969
5SCL_19346495_ChIP-Seq_HPC-7_Human3.25190061
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15708423
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07054909
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05191580
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00718587
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87811836
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69538916
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61156870
13GATA1_22025678_ChIP-Seq_K562_Human2.27537772
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10951702
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.00736732
16HTT_18923047_ChIP-ChIP_STHdh_Human1.81410184
17VDR_22108803_ChIP-Seq_LS180_Human1.78260556
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73556074
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.71946225
20GBX2_23144817_ChIP-Seq_PC3_Human1.69465814
21ER_23166858_ChIP-Seq_MCF-7_Human1.68665673
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65662514
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64872554
24TAF15_26573619_Chip-Seq_HEK293_Human1.62650517
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.62321465
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61326524
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.52991330
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51301587
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50076821
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48843106
31BCAT_22108803_ChIP-Seq_LS180_Human1.47984551
32CDX2_22108803_ChIP-Seq_LS180_Human1.46093750
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.43849099
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.40035346
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39850472
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39850472
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.37761716
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33274665
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33107761
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32456744
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28536139
42CBP_20019798_ChIP-Seq_JUKART_Human1.25557626
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25557626
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24714016
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.23934573
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23337453
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22552837
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22293261
49IRF1_19129219_ChIP-ChIP_H3396_Human1.21447349
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20301807
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.19436210
52GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17515800
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16426376
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16358203
55HNF4A_19822575_ChIP-Seq_HepG2_Human1.15306899
56TP53_18474530_ChIP-ChIP_U2OS_Human1.13538621
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12830439
58OCT4_18555785_Chip-Seq_ESCs_Mouse1.11881779
59SALL4_22934838_ChIP-ChIP_CD34+_Human1.11444992
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.11201633
61NFYA_21822215_ChIP-Seq_K562_Human1.10628990
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09626352
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09611043
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09053697
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08421460
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06934297
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.06862157
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05711336
69HNFA_21074721_ChIP-Seq_CACO-2_Human1.05607599
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05099100
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04886483
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04286096
73TCF4_23295773_ChIP-Seq_U87_Human1.03020757
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.02745340
75GATA2_19941826_ChIP-Seq_K562_Human1.02654388
76PHF8_20622853_ChIP-Seq_HELA_Human1.02127094
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02118084
78FOXA1_25552417_ChIP-Seq_VCAP_Human0.99109471
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98929383
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98605100
81CJUN_26792858_Chip-Seq_BT549_Human0.98434339
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98303368
83ETV1_20927104_ChIP-Seq_GIST48_Human0.98235235
84CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97988838
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97397471
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97308453
87AR_20517297_ChIP-Seq_VCAP_Human0.96962228
88GATA4_25053715_ChIP-Seq_YYC3_Human0.96617193
89AR_25329375_ChIP-Seq_VCAP_Human0.96439692
90GATA1_19941826_ChIP-Seq_K562_Human0.96267632
91STAT3_23295773_ChIP-Seq_U87_Human0.96237374
92NFYB_21822215_ChIP-Seq_K562_Human0.95889562
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95255837
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94312308
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94050154
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.93651835
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93259055
98P300_19829295_ChIP-Seq_ESCs_Human0.92969051
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92360279
100TCF4_22108803_ChIP-Seq_LS180_Human0.92090836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37667049
2MP0003252_abnormal_bile_duct5.84664384
3MP0005085_abnormal_gallbladder_physiolo5.57560040
4MP0005365_abnormal_bile_salt5.38122798
5MP0002138_abnormal_hepatobiliary_system4.60678683
6MP0008875_abnormal_xenobiotic_pharmacok4.11843370
7MP0003195_calcinosis3.76561864
8MP0005464_abnormal_platelet_physiology3.72062330
9MP0005670_abnormal_white_adipose3.50646426
10MP0005360_urolithiasis3.12477272
11MP0009697_abnormal_copulation2.90889492
12MP0003868_abnormal_feces_composition2.89129683
13MP0001666_abnormal_nutrient_absorption2.74525220
14MP0005187_abnormal_penis_morphology2.34891539
15MP0000569_abnormal_digit_pigmentation2.29255224
16MP0010329_abnormal_lipoprotein_level2.21450553
17MP0003191_abnormal_cellular_cholesterol2.17371639
18MP0003806_abnormal_nucleotide_metabolis1.95870515
19MP0010368_abnormal_lymphatic_system1.90737075
20MP0005332_abnormal_amino_acid1.89966730
21MP0005084_abnormal_gallbladder_morpholo1.80789976
22MP0003300_gastrointestinal_ulcer1.71454110
23MP0000609_abnormal_liver_physiology1.61392036
24MP0002118_abnormal_lipid_homeostasis1.59974023
25MP0001661_extended_life_span1.37683846
26MP0002876_abnormal_thyroid_physiology1.33707728
27MP0005397_hematopoietic_system_phenotyp1.26751582
28MP0001545_abnormal_hematopoietic_system1.26751582
29MP0003724_increased_susceptibility_to1.19966658
30MP0009763_increased_sensitivity_to1.13715724
31MP0009764_decreased_sensitivity_to1.12401017
32MP0000598_abnormal_liver_morphology1.12019379
33MP0002928_abnormal_bile_duct1.11865252
34MP0005319_abnormal_enzyme/_coenzyme1.06311809
35MP0001764_abnormal_homeostasis1.01017851
36MP0008775_abnormal_heart_ventricle0.99734675
37MP0000858_altered_metastatic_potential0.98592287
38MP0004084_abnormal_cardiac_muscle0.92921076
39MP0000343_altered_response_to0.92240000
40MP0009642_abnormal_blood_homeostasis0.89792431
41MP0003828_pulmonary_edema0.89078828
42MP0000230_abnormal_systemic_arterial0.87798494
43MP0008469_abnormal_protein_level0.85892020
44MP0008004_abnormal_stomach_pH0.83959727
45MP0003656_abnormal_erythrocyte_physiolo0.83371139
46MP0001915_intracranial_hemorrhage0.82584371
47MP0003279_aneurysm0.79565802
48MP0005584_abnormal_enzyme/coenzyme_acti0.79125585
49MP0009053_abnormal_anal_canal0.77956524
50MP0002132_abnormal_respiratory_system0.77306207
51MP0009643_abnormal_urine_homeostasis0.77135091
52MP0006276_abnormal_autonomic_nervous0.77002845
53MP0002009_preneoplasia0.75712229
54MP0005636_abnormal_mineral_homeostasis0.72139531
55MP0004215_abnormal_myocardial_fiber0.72059189
56MP0008872_abnormal_physiological_respon0.71782455
57MP0002396_abnormal_hematopoietic_system0.71746510
58MP0009765_abnormal_xenobiotic_induced0.69765664
59MP0002128_abnormal_blood_circulation0.69588074
60MP0005164_abnormal_response_to0.68606971
61MP0009384_cardiac_valve_regurgitation0.67784316
62MP0005376_homeostasis/metabolism_phenot0.67495362
63MP0005595_abnormal_vascular_smooth0.63938792
64MP0001845_abnormal_inflammatory_respons0.62527161
65MP0002148_abnormal_hypersensitivity_rea0.62406189
66MP0000465_gastrointestinal_hemorrhage0.61595165
67MP0000249_abnormal_blood_vessel0.60844559
68MP0004019_abnormal_vitamin_homeostasis0.60104014
69MP0004036_abnormal_muscle_relaxation0.59817268
70MP0001986_abnormal_taste_sensitivity0.58781632
71MP0010155_abnormal_intestine_physiology0.56476690
72MP0004130_abnormal_muscle_cell0.56458085
73MP0005083_abnormal_biliary_tract0.54811190
74MP0005395_other_phenotype0.54379931
75MP0000639_abnormal_adrenal_gland0.54307417
76MP0005535_abnormal_body_temperature0.54221304
77MP0003718_maternal_effect0.54093076
78MP0004808_abnormal_hematopoietic_stem0.53179249
79MP0003011_delayed_dark_adaptation0.52716595
80MP0003315_abnormal_perineum_morphology0.52586296
81MP0005409_darkened_coat_color0.52325501
82MP0003638_abnormal_response/metabolism_0.51698553
83MP0005166_decreased_susceptibility_to0.51249744
84MP0001756_abnormal_urination0.49985136
85MP0004133_heterotaxia0.48302137
86MP0006138_congestive_heart_failure0.47957999
87MP0005666_abnormal_adipose_tissue0.47180210
88MP0005165_increased_susceptibility_to0.47120243
89MP0005023_abnormal_wound_healing0.46966768
90MP0003633_abnormal_nervous_system0.44941386
91MP0002136_abnormal_kidney_physiology0.44683684
92MP0001851_eye_inflammation0.43415291
93MP0005385_cardiovascular_system_phenoty0.42312069
94MP0001544_abnormal_cardiovascular_syste0.42312069
95MP0006036_abnormal_mitochondrial_physio0.42187670
96MP0003763_abnormal_thymus_physiology0.41954706
97MP0002282_abnormal_trachea_morphology0.41200386
98MP0004484_altered_response_of0.40676211
99MP0000689_abnormal_spleen_morphology0.39585587
100MP0002078_abnormal_glucose_homeostasis0.39488021

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)9.89843206
2Conjugated hyperbilirubinemia (HP:0002908)8.94586202
3Abnormality of complement system (HP:0005339)7.71014578
4Spontaneous abortion (HP:0005268)7.05881216
5Prolonged partial thromboplastin time (HP:0003645)6.81021260
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.68165574
7Deep venous thrombosis (HP:0002625)6.49307203
8Abnormality of the common coagulation pathway (HP:0010990)5.73274434
9Intrahepatic cholestasis (HP:0001406)5.61081912
10Glomerulonephritis (HP:0000099)5.57625610
11Gingival bleeding (HP:0000225)5.53492456
12Abnormality of aromatic amino acid family metabolism (HP:0004338)5.47782189
13Hypobetalipoproteinemia (HP:0003563)5.35669683
14Joint hemorrhage (HP:0005261)4.95237300
15Systemic lupus erythematosus (HP:0002725)4.57661886
16Hyperlipoproteinemia (HP:0010980)4.53862312
17Recurrent gram-negative bacterial infections (HP:0005420)4.41298977
18Prolonged bleeding time (HP:0003010)4.37553537
19Menorrhagia (HP:0000132)4.27014012
20Epistaxis (HP:0000421)4.19063205
21Purpura (HP:0000979)4.02551366
22Abnormality of the intrinsic pathway (HP:0010989)3.97434489
23Nephritis (HP:0000123)3.91608784
24Abnormality of pyrimidine metabolism (HP:0004353)3.78724594
25Increased mean platelet volume (HP:0011877)3.75495021
26Fat malabsorption (HP:0002630)3.56385900
27Abnormal platelet volume (HP:0011876)3.45739038
28Abnormal platelet function (HP:0011869)3.31684018
29Impaired platelet aggregation (HP:0003540)3.31684018
30Thrombophlebitis (HP:0004418)3.26714113
31Xanthomatosis (HP:0000991)3.25726989
32Joint swelling (HP:0001386)3.20460560
33Hypolipoproteinemia (HP:0010981)2.96244548
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93648288
35Generalized aminoaciduria (HP:0002909)2.88003474
36Enlarged kidneys (HP:0000105)2.76321476
37Hepatocellular carcinoma (HP:0001402)2.75658217
38Abnormality of methionine metabolism (HP:0010901)2.75631823
39Abnormal biliary tract physiology (HP:0012439)2.70731635
40Bile duct proliferation (HP:0001408)2.70731635
41Hypoalphalipoproteinemia (HP:0003233)2.64547225
42Acanthocytosis (HP:0001927)2.62684545
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55709472
44Abnormal delivery (HP:0001787)2.53766081
45Poikilocytosis (HP:0004447)2.52842653
46Hyperbilirubinemia (HP:0002904)2.52742538
47Petechiae (HP:0000967)2.52741754
48Renal cortical cysts (HP:0000803)2.51089836
49Hypophosphatemic rickets (HP:0004912)2.47670974
50Pulmonary embolism (HP:0002204)2.41943480
51Abnormality of nucleobase metabolism (HP:0010932)2.38147243
52Mitral stenosis (HP:0001718)2.32816260
53Hypercholesterolemia (HP:0003124)2.32646222
54Rickets (HP:0002748)2.29482289
55Steatorrhea (HP:0002570)2.20387087
56Abnormality of transition element cation homeostasis (HP:0011030)2.19309421
57Reduced antithrombin III activity (HP:0001976)2.18570787
58Amyloidosis (HP:0011034)2.17353196
59Abnormality of iron homeostasis (HP:0011031)2.15998449
60Increased serum ferritin (HP:0003281)2.13768604
61Potter facies (HP:0002009)2.12616161
62Facial shape deformation (HP:0011334)2.12616161
63Hemorrhage of the eye (HP:0011885)2.09634468
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07199400
65Delayed CNS myelination (HP:0002188)2.07144461
66Abnormality of proline metabolism (HP:0010907)2.01471962
67Hydroxyprolinuria (HP:0003080)2.01471962
68Abnormality of the renal cortex (HP:0011035)2.00408635
69Vascular calcification (HP:0004934)2.00137278
70Osteomalacia (HP:0002749)1.96547479
71Cholelithiasis (HP:0001081)1.95884053
72Abnormality of sulfur amino acid metabolism (HP:0004339)1.94496212
73Neonatal hypoglycemia (HP:0001998)1.94058473
74Hyperglycinuria (HP:0003108)1.93433898
75Spontaneous hematomas (HP:0007420)1.87577643
76Abnormality of the heme biosynthetic pathway (HP:0010472)1.86356745
77Hyperammonemia (HP:0001987)1.82862501
78Abnormality of alanine metabolism (HP:0010916)1.82107211
79Hyperalaninemia (HP:0003348)1.82107211
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82107211
81Dry hair (HP:0011359)1.81911509
82Hyperglycinemia (HP:0002154)1.78332748
83Conjunctival telangiectasia (HP:0000524)1.77188168
84Abnormal gallbladder morphology (HP:0012437)1.76302245
85Cardiovascular calcification (HP:0011915)1.75757682
86Abnormality of purine metabolism (HP:0004352)1.73715956
87Fair hair (HP:0002286)1.71662784
88Submucous cleft hard palate (HP:0000176)1.69812181
89Abnormality of serine family amino acid metabolism (HP:0010894)1.64622731
90Abnormality of glycine metabolism (HP:0010895)1.64622731
91Elevated alkaline phosphatase (HP:0003155)1.62487067
92Widely patent fontanelles and sutures (HP:0004492)1.62319867
93Abnormal enzyme/coenzyme activity (HP:0012379)1.61025912
94Hypothermia (HP:0002045)1.60661403
95Abnormality of serum amino acid levels (HP:0003112)1.59381034
96Metabolic acidosis (HP:0001942)1.59009251
97Increased serum pyruvate (HP:0003542)1.56978851
98Gout (HP:0001997)1.55801673
99Cerebral palsy (HP:0100021)1.54479579
100Arthropathy (HP:0003040)1.52264124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.55384251
2PIK3CG3.41426129
3MAP3K133.36772564
4TAOK33.26819974
5BMPR1B3.22797188
6CLK12.57387004
7TEC2.56581887
8CDK62.20373047
9EIF2AK12.09587851
10WNK31.77759287
11MAP3K71.64687335
12PLK21.63806310
13CDK81.62505720
14EIF2AK31.60644602
15MYLK1.51471903
16BRSK21.48012554
17CSNK1G21.47942416
18FRK1.44586356
19TXK1.44083382
20CSNK1G11.43827140
21ADRBK21.37226454
22BTK1.36829612
23CDK91.36404340
24CAMKK21.35512386
25CSNK1G31.34968240
26PRKG21.34594529
27BMPR21.34398872
28PIK3CA1.29458739
29PNCK1.27924431
30NTRK31.27631481
31MAPKAPK31.26292319
32PRKACG1.25849127
33INSRR1.20877245
34EPHA31.20245404
35MAP4K21.18694970
36JAK11.17789098
37TGFBR11.17332026
38PRKG11.16127273
39MAP3K21.15241765
40AKT31.13595437
41FGFR31.10127322
42IKBKB1.08280289
43STK391.07560534
44STK31.05801678
45SCYL21.03989142
46ACVR1B1.00042988
47JAK20.98948918
48TBK10.96605199
49HIPK20.96439690
50MAPK110.94952023
51MST40.91612531
52BCR0.91589852
53MKNK20.90966161
54SYK0.89786180
55MAP3K90.84674763
56NEK90.84307136
57MAP2K10.83544440
58ITK0.83425304
59PRKCQ0.81284584
60BMX0.81126871
61PLK40.79171493
62HCK0.78485277
63RAF10.78262830
64ZAK0.74847902
65MAP3K120.74663572
66WNK40.73876653
67ABL20.72149897
68FGFR40.67215102
69PDK10.67011249
70NLK0.66210971
71CSF1R0.66060660
72IGF1R0.65201784
73PTK2B0.64591489
74PDPK10.63991332
75GRK50.61599676
76PRKAA20.61122892
77PRKCE0.59522921
78GRK60.59391420
79PHKG10.59309934
80PHKG20.59309934
81GRK10.59172687
82OXSR10.59078935
83CDK30.58595784
84PDGFRB0.55409303
85ADRBK10.54380046
86PDGFRA0.53994560
87FER0.52332527
88RIPK40.51471736
89IRAK10.46893785
90TIE10.46686341
91CSNK1E0.46085963
92MAPK130.45733872
93MAP3K10.45562693
94PRKACA0.44711973
95CSNK1A1L0.42969111
96TRIM280.42291841
97EIF2AK20.42014617
98PIM20.41554367
99LYN0.41197850
100CDK70.37338538

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.74772468
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.92156208
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.70184452
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.65687297
5Retinol metabolism_Homo sapiens_hsa008303.44749186
6Caffeine metabolism_Homo sapiens_hsa002323.16969806
7Pentose and glucuronate interconversions_Homo sapiens_hsa000403.03816184
8Primary bile acid biosynthesis_Homo sapiens_hsa001203.03413433
9Chemical carcinogenesis_Homo sapiens_hsa052042.97520498
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.93566280
11Linoleic acid metabolism_Homo sapiens_hsa005912.93459595
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.88220693
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.62590643
14Arachidonic acid metabolism_Homo sapiens_hsa005902.13364510
15Vitamin B6 metabolism_Homo sapiens_hsa007502.13063937
16Tyrosine metabolism_Homo sapiens_hsa003502.03418839
17Bile secretion_Homo sapiens_hsa049762.02579381
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.97773296
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97214132
20Prion diseases_Homo sapiens_hsa050201.96563405
21Phenylalanine metabolism_Homo sapiens_hsa003601.81846746
22Staphylococcus aureus infection_Homo sapiens_hsa051501.79774358
23Arginine biosynthesis_Homo sapiens_hsa002201.78339663
24Tryptophan metabolism_Homo sapiens_hsa003801.74662092
25Starch and sucrose metabolism_Homo sapiens_hsa005001.71126549
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69587182
27Butanoate metabolism_Homo sapiens_hsa006501.67848768
28ABC transporters_Homo sapiens_hsa020101.49775522
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46462236
30Fatty acid degradation_Homo sapiens_hsa000711.45577039
31Histidine metabolism_Homo sapiens_hsa003401.40418751
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24790122
33PPAR signaling pathway_Homo sapiens_hsa033201.20227681
34Fat digestion and absorption_Homo sapiens_hsa049751.20105524
35Platelet activation_Homo sapiens_hsa046111.17404088
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.13149300
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12975247
38One carbon pool by folate_Homo sapiens_hsa006701.04262682
39Peroxisome_Homo sapiens_hsa041460.99600268
40beta-Alanine metabolism_Homo sapiens_hsa004100.99110672
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95359936
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93095622
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.87213913
44Arginine and proline metabolism_Homo sapiens_hsa003300.77800001
45Pancreatic secretion_Homo sapiens_hsa049720.77662275
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74590319
47Glycerolipid metabolism_Homo sapiens_hsa005610.69164167
48Fatty acid biosynthesis_Homo sapiens_hsa000610.67266312
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65975686
50Propanoate metabolism_Homo sapiens_hsa006400.62645586
51Serotonergic synapse_Homo sapiens_hsa047260.60947902
52Pyruvate metabolism_Homo sapiens_hsa006200.57485140
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.53909998
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46304093
55Biosynthesis of amino acids_Homo sapiens_hsa012300.46043117
56Fatty acid metabolism_Homo sapiens_hsa012120.45493057
57Sulfur metabolism_Homo sapiens_hsa009200.44194944
58Systemic lupus erythematosus_Homo sapiens_hsa053220.43062535
59Metabolic pathways_Homo sapiens_hsa011000.36379223
60Nitrogen metabolism_Homo sapiens_hsa009100.35631304
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.35458259
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.31485063
63Pertussis_Homo sapiens_hsa051330.27582640
64Amoebiasis_Homo sapiens_hsa051460.26183926
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23851579
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23415971
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22774808
68Carbon metabolism_Homo sapiens_hsa012000.22718784
69Dorso-ventral axis formation_Homo sapiens_hsa043200.21004213
70Insulin resistance_Homo sapiens_hsa049310.20718666
71Ovarian steroidogenesis_Homo sapiens_hsa049130.18998149
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.16292642
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05923204
74Fatty acid elongation_Homo sapiens_hsa000620.05667429
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04668789
76Glucagon signaling pathway_Homo sapiens_hsa049220.04608205
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03293384
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03193573
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03021778
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.03011217
81Vitamin digestion and absorption_Homo sapiens_hsa049770.02485274
82Renin secretion_Homo sapiens_hsa049240.02376366
83Hematopoietic cell lineage_Homo sapiens_hsa046400.02069063
84Olfactory transduction_Homo sapiens_hsa047400.01150517
85Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1045798
86Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0989160
87Sulfur relay system_Homo sapiens_hsa04122-0.0932273
88Glutathione metabolism_Homo sapiens_hsa00480-0.0916570
89Long-term potentiation_Homo sapiens_hsa04720-0.0784885
90Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0781733
91Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0720825
92Steroid biosynthesis_Homo sapiens_hsa00100-0.0656808
93Long-term depression_Homo sapiens_hsa04730-0.0522895
94Chemokine signaling pathway_Homo sapiens_hsa04062-0.0384874
95Ether lipid metabolism_Homo sapiens_hsa00565-0.0365134
96Salivary secretion_Homo sapiens_hsa04970-0.0360953
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0334774
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0194171
99Selenocompound metabolism_Homo sapiens_hsa00450-0.0109276
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0043585

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