AKR1C6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)8.76229814
2exogenous drug catabolic process (GO:0042738)7.92331029
3drug catabolic process (GO:0042737)7.75223297
4epoxygenase P450 pathway (GO:0019373)7.21786498
5regulation of fibrinolysis (GO:0051917)6.77486953
6negative regulation of fibrinolysis (GO:0051918)6.69111050
7L-phenylalanine catabolic process (GO:0006559)6.66901920
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.66901920
9omega-hydroxylase P450 pathway (GO:0097267)6.58998069
10complement activation, alternative pathway (GO:0006957)6.27632152
11regulation of protein activation cascade (GO:2000257)6.05149494
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.92881847
13L-phenylalanine metabolic process (GO:0006558)5.92881847
14urea metabolic process (GO:0019627)5.81414978
15cellular glucuronidation (GO:0052695)5.74039249
16uronic acid metabolic process (GO:0006063)5.72022707
17glucuronate metabolic process (GO:0019585)5.72022707
18regulation of triglyceride catabolic process (GO:0010896)5.66414761
19regulation of complement activation (GO:0030449)5.51884613
20fibrinolysis (GO:0042730)5.39610060
21nitrogen cycle metabolic process (GO:0071941)5.37909809
22oxidative demethylation (GO:0070989)5.37149869
23drug metabolic process (GO:0017144)5.33529117
24phenylpropanoid metabolic process (GO:0009698)5.27607489
25aromatic amino acid family catabolic process (GO:0009074)5.10063103
26glycine metabolic process (GO:0006544)5.08243148
27serine family amino acid catabolic process (GO:0009071)5.07431598
28urea cycle (GO:0000050)4.94688932
29bile acid biosynthetic process (GO:0006699)4.86160005
30protein carboxylation (GO:0018214)4.86095445
31peptidyl-glutamic acid carboxylation (GO:0017187)4.86095445
32positive regulation of lipoprotein lipase activity (GO:0051006)4.84061666
33positive regulation of triglyceride lipase activity (GO:0061365)4.84061666
34blood coagulation, intrinsic pathway (GO:0007597)4.80522161
35bile acid metabolic process (GO:0008206)4.65199330
36ethanol oxidation (GO:0006069)4.51213972
37tryptophan metabolic process (GO:0006568)4.49508043
38bile acid and bile salt transport (GO:0015721)4.47754602
39daunorubicin metabolic process (GO:0044597)4.42645758
40polyketide metabolic process (GO:0030638)4.42645758
41doxorubicin metabolic process (GO:0044598)4.42645758
42negative regulation of cholesterol transport (GO:0032375)4.40235012
43negative regulation of sterol transport (GO:0032372)4.40235012
44tyrosine metabolic process (GO:0006570)4.39819042
45regulation of plasminogen activation (GO:0010755)4.32928116
46negative regulation of hemostasis (GO:1900047)4.19293190
47negative regulation of blood coagulation (GO:0030195)4.19293190
48triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16435495
49triglyceride homeostasis (GO:0070328)4.13886976
50acylglycerol homeostasis (GO:0055090)4.13886976
51hormone catabolic process (GO:0042447)4.10920782
52aromatic amino acid family metabolic process (GO:0009072)4.08014659
53serine family amino acid metabolic process (GO:0009069)3.99997440
54S-adenosylmethionine metabolic process (GO:0046500)3.96643841
55alkaloid metabolic process (GO:0009820)3.95069241
56aminoglycoside antibiotic metabolic process (GO:0030647)3.94068294
57protein activation cascade (GO:0072376)3.91034507
58regulation of cholesterol esterification (GO:0010872)3.79130231
59amino-acid betaine metabolic process (GO:0006577)3.75486859
60negative regulation of coagulation (GO:0050819)3.75070733
61acute-phase response (GO:0006953)3.75025138
62indole-containing compound catabolic process (GO:0042436)3.70650821
63indolalkylamine catabolic process (GO:0046218)3.70650821
64tryptophan catabolic process (GO:0006569)3.70650821
65complement activation (GO:0006956)3.70634159
66negative regulation of wound healing (GO:0061045)3.63751712
67phospholipid efflux (GO:0033700)3.63217054
68aldehyde catabolic process (GO:0046185)3.59737479
69dopamine transport (GO:0015872)3.58859395
70ethanol metabolic process (GO:0006067)3.57191277
71imidazole-containing compound metabolic process (GO:0052803)3.55057111
72complement activation, classical pathway (GO:0006958)3.54465240
73regulation of humoral immune response (GO:0002920)3.51985315
74flavonoid metabolic process (GO:0009812)3.49720780
75negative regulation of protein activation cascade (GO:2000258)3.47423746
76macromolecular complex remodeling (GO:0034367)3.46486970
77plasma lipoprotein particle remodeling (GO:0034369)3.46486970
78protein-lipid complex remodeling (GO:0034368)3.46486970
79alpha-amino acid catabolic process (GO:1901606)3.46274829
80regulation of lipoprotein particle clearance (GO:0010984)3.46093013
81opsonization (GO:0008228)3.31455503
82cellular ketone body metabolic process (GO:0046950)3.31062756
83disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.30582204
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.30582204
85negative regulation of lipase activity (GO:0060192)3.30470120
86positive regulation of fatty acid biosynthetic process (GO:0045723)3.26028217
87serine family amino acid biosynthetic process (GO:0009070)3.25728301
88fat-soluble vitamin biosynthetic process (GO:0042362)3.22468953
89steroid catabolic process (GO:0006706)3.22433319
90xenobiotic metabolic process (GO:0006805)3.21283398
91high-density lipoprotein particle remodeling (GO:0034375)3.20812819
92drug transmembrane transport (GO:0006855)3.17769056
93positive regulation of hemostasis (GO:1900048)3.17646696
94positive regulation of blood coagulation (GO:0030194)3.17646696
95cytolysis (GO:0019835)3.17417946
96arginine metabolic process (GO:0006525)3.16288576
97very-low-density lipoprotein particle assembly (GO:0034379)3.14804272
98cellular amino acid catabolic process (GO:0009063)3.13454870
99ketone body metabolic process (GO:1902224)3.13121427
100indolalkylamine metabolic process (GO:0006586)3.08609550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.78508065
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.07802959
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.81635329
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.99765015
5CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.67460624
6E2F7_22180533_ChIP-Seq_HELA_Human4.50860254
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.35745162
8IRF8_22096565_ChIP-ChIP_GC-B_Human4.17652406
9PPARA_22158963_ChIP-Seq_LIVER_Mouse4.12991278
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.76658730
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.74242718
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64860246
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61282475
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17437727
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17205158
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89854625
17IRF1_19129219_ChIP-ChIP_H3396_Human1.89314868
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.80723262
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75420906
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65308611
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62592000
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58580711
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48842185
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47712551
25HNF4A_19822575_ChIP-Seq_HepG2_Human1.41725286
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33793969
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31694270
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30647562
29SCL_19346495_ChIP-Seq_HPC-7_Human1.23454988
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.23059274
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20027164
32HTT_18923047_ChIP-ChIP_STHdh_Human1.16647671
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.16202445
34AR_20517297_ChIP-Seq_VCAP_Human1.14554492
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13931627
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13160125
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11328275
38BCL6_27268052_Chip-Seq_Bcells_Human1.10506763
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.09875377
40CEBPB_22108803_ChIP-Seq_LS180_Human1.09764993
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.08766273
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07654576
43FOXH1_21741376_ChIP-Seq_EPCs_Human1.07403144
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05982130
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05432490
46P300_27268052_Chip-Seq_Bcells_Human1.04623158
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03512560
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02352273
49SOX2_21211035_ChIP-Seq_LN229_Human0.99956818
50STAT1_20625510_ChIP-Seq_HELA_Human0.99638228
51CBP_21632823_ChIP-Seq_H3396_Human0.97147886
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96603162
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94829027
54SPI1_20517297_ChIP-Seq_HL60_Human0.94125611
55GATA6_21074721_ChIP-Seq_CACO-2_Human0.92839394
56HNFA_21074721_ChIP-Seq_CACO-2_Human0.89472249
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89065984
58GABP_17652178_ChIP-ChIP_JURKAT_Human0.86275560
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85304986
60BCOR_27268052_Chip-Seq_Bcells_Human0.84147154
61ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84107467
62FOXA1_25329375_ChIP-Seq_VCAP_Human0.83971666
63FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83971666
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83523475
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82264488
66GATA3_26560356_Chip-Seq_TH2_Human0.80939531
67GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80720910
68CTCF_20526341_ChIP-Seq_ESCs_Human0.80501782
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80403789
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80256331
71NANOG_20526341_ChIP-Seq_ESCs_Human0.79258041
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.78428014
73ZNF274_21170338_ChIP-Seq_K562_Hela0.77320540
74ERG_20517297_ChIP-Seq_VCAP_Human0.77260971
75RAC3_21632823_ChIP-Seq_H3396_Human0.77165305
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.76563113
77TAF2_19829295_ChIP-Seq_ESCs_Human0.76214386
78KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76109277
79PHF8_20622853_ChIP-Seq_HELA_Human0.76103626
80E2F1_20622854_ChIP-Seq_HELA_Human0.75071182
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74724701
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74197412
83ERA_21632823_ChIP-Seq_H3396_Human0.73014607
84CBP_20019798_ChIP-Seq_JUKART_Human0.72825291
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72825291
86MYB_26560356_Chip-Seq_TH1_Human0.71860900
87SOX2_19829295_ChIP-Seq_ESCs_Human0.71611296
88NANOG_19829295_ChIP-Seq_ESCs_Human0.71611296
89NFYA_21822215_ChIP-Seq_K562_Human0.70186928
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69126761
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68593004
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.68296638
93P53_21459846_ChIP-Seq_SAOS-2_Human0.67787256
94SOX2_22085726_ChIP-Seq_NPCs_Mouse0.67087936
95MYC_19829295_ChIP-Seq_ESCs_Human0.66933034
96GATA3_27048872_Chip-Seq_THYMUS_Human0.66320614
97SPI1_23547873_ChIP-Seq_NB4_Human0.66142211
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.66070578
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.66019926
100NCOR_22424771_ChIP-Seq_293T_Human0.64937662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.66884802
2MP0005085_abnormal_gallbladder_physiolo5.00971928
3MP0002138_abnormal_hepatobiliary_system4.79604879
4MP0005360_urolithiasis4.75425987
5MP0008875_abnormal_xenobiotic_pharmacok4.72269619
6MP0005365_abnormal_bile_salt4.54273276
7MP0003195_calcinosis4.04139455
8MP0003252_abnormal_bile_duct3.75109762
9MP0009697_abnormal_copulation3.65756767
10MP0003806_abnormal_nucleotide_metabolis3.60700911
11MP0003868_abnormal_feces_composition3.13566429
12MP0002876_abnormal_thyroid_physiology2.81107335
13MP0001666_abnormal_nutrient_absorption2.75035913
14MP0010329_abnormal_lipoprotein_level2.22916334
15MP0002822_catalepsy2.11695035
16MP0003183_abnormal_peptide_metabolism2.10584929
17MP0000372_irregular_coat_pigmentation1.81270244
18MP0001764_abnormal_homeostasis1.77984415
19MP0005332_abnormal_amino_acid1.77103898
20MP0003191_abnormal_cellular_cholesterol1.76569289
21MP0008872_abnormal_physiological_respon1.59381661
22MP0000609_abnormal_liver_physiology1.53287334
23MP0005451_abnormal_body_composition1.53145678
24MP0002118_abnormal_lipid_homeostasis1.43380784
25MP0005319_abnormal_enzyme/_coenzyme1.38522930
26MP0005408_hypopigmentation1.36306268
27MP0003656_abnormal_erythrocyte_physiolo1.35321408
28MP0009840_abnormal_foam_cell1.33840743
29MP0010368_abnormal_lymphatic_system1.29523502
30MP0001986_abnormal_taste_sensitivity1.29260260
31MP0001545_abnormal_hematopoietic_system1.27962516
32MP0005397_hematopoietic_system_phenotyp1.27962516
33MP0005075_abnormal_melanosome_morpholog1.25644459
34MP0006036_abnormal_mitochondrial_physio1.19860137
35MP0005464_abnormal_platelet_physiology1.14458622
36MP0005584_abnormal_enzyme/coenzyme_acti1.13075435
37MP0005187_abnormal_penis_morphology1.11498340
38MP0009278_abnormal_bone_marrow1.09134816
39MP0005266_abnormal_metabolism1.05196675
40MP0002132_abnormal_respiratory_system1.04856529
41MP0001835_abnormal_antigen_presentation1.02519735
42MP0009643_abnormal_urine_homeostasis1.01698516
43MP0008469_abnormal_protein_level1.01437707
44MP0005220_abnormal_exocrine_pancreas1.00513389
45MP0005376_homeostasis/metabolism_phenot0.97212946
46MP0003186_abnormal_redox_activity0.94408670
47MP0009764_decreased_sensitivity_to0.93332826
48MP0000598_abnormal_liver_morphology0.92173924
49MP0009785_altered_susceptibility_to0.86775414
50MP0008058_abnormal_DNA_repair0.86021688
51MP0002396_abnormal_hematopoietic_system0.85160968
52MP0006035_abnormal_mitochondrial_morpho0.83433553
53MP0002735_abnormal_chemical_nociception0.82591282
54MP0009642_abnormal_blood_homeostasis0.81721161
55MP0002148_abnormal_hypersensitivity_rea0.79322889
56MP0001800_abnormal_humoral_immune0.77477547
57MP0009763_increased_sensitivity_to0.77400182
58MP0004019_abnormal_vitamin_homeostasis0.76346744
59MP0000604_amyloidosis0.73001938
60MP0005670_abnormal_white_adipose0.71901011
61MP0001661_extended_life_span0.70843990
62MP0005636_abnormal_mineral_homeostasis0.70380196
63MP0003724_increased_susceptibility_to0.68567895
64MP0005084_abnormal_gallbladder_morpholo0.67616059
65MP0010094_abnormal_chromosome_stability0.65421272
66MP0002928_abnormal_bile_duct0.62951843
67MP0008873_increased_physiological_sensi0.62648295
68MP0001790_abnormal_immune_system0.62569379
69MP0005387_immune_system_phenotype0.62569379
70MP0009765_abnormal_xenobiotic_induced0.62456764
71MP0002419_abnormal_innate_immunity0.62087101
72MP0003959_abnormal_lean_body0.59172967
73MP0005025_abnormal_response_to0.58706240
74MP0004147_increased_porphyrin_level0.58041748
75MP0002452_abnormal_antigen_presenting0.57670125
76MP0005000_abnormal_immune_tolerance0.57604479
77MP0002723_abnormal_immune_serum0.57574161
78MP0005058_abnormal_lysosome_morphology0.55871059
79MP0000689_abnormal_spleen_morphology0.55210526
80MP0002332_abnormal_exercise_endurance0.54685137
81MP0005167_abnormal_blood-brain_barrier0.54591623
82MP0001845_abnormal_inflammatory_respons0.53796617
83MP0005379_endocrine/exocrine_gland_phen0.51957624
84MP0005645_abnormal_hypothalamus_physiol0.51879172
85MP0004043_abnormal_pH_regulation0.51823329
86MP0003638_abnormal_response/metabolism_0.51362393
87MP0002282_abnormal_trachea_morphology0.51177831
88MP0001915_intracranial_hemorrhage0.50215239
89MP0005535_abnormal_body_temperature0.48807033
90MP0003718_maternal_effect0.48603949
91MP0005171_absent_coat_pigmentation0.48507445
92MP0008877_abnormal_DNA_methylation0.48232104
93MP0002971_abnormal_brown_adipose0.47982633
94MP0002420_abnormal_adaptive_immunity0.47270738
95MP0001819_abnormal_immune_cell0.46522962
96MP0005395_other_phenotype0.45966532
97MP0010386_abnormal_urinary_bladder0.45655201
98MP0001881_abnormal_mammary_gland0.45282440
99MP0008874_decreased_physiological_sensi0.44205624
100MP0000716_abnormal_immune_system0.43165568

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.37900802
2Deep venous thrombosis (HP:0002625)7.65048361
3Prolonged partial thromboplastin time (HP:0003645)6.52943403
4Complement deficiency (HP:0004431)6.52001988
5Hypobetalipoproteinemia (HP:0003563)6.16601524
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.15873203
7Abnormality of complement system (HP:0005339)4.94220534
8Conjugated hyperbilirubinemia (HP:0002908)4.92303210
9Systemic lupus erythematosus (HP:0002725)4.70607868
10Hyperlipoproteinemia (HP:0010980)4.56514606
11Joint hemorrhage (HP:0005261)4.33528501
12Agammaglobulinemia (HP:0004432)4.31570359
13B lymphocytopenia (HP:0010976)4.29274194
14Abnormality of pyrimidine metabolism (HP:0004353)4.11055808
15Abnormality of B cell number (HP:0010975)4.00698236
16Intrahepatic cholestasis (HP:0001406)3.96928653
17Spontaneous abortion (HP:0005268)3.76035000
18Severe combined immunodeficiency (HP:0004430)3.71164936
19Recurrent gram-negative bacterial infections (HP:0005420)3.59994787
20Thyroiditis (HP:0100646)3.53764124
21Glomerulonephritis (HP:0000099)3.44061099
22Reduced antithrombin III activity (HP:0001976)3.42290328
23Panhypogammaglobulinemia (HP:0003139)3.31167265
24Hyperammonemia (HP:0001987)3.19470809
25Abnormality of the common coagulation pathway (HP:0010990)3.16562004
26Hypolipoproteinemia (HP:0010981)3.16057726
27Xanthomatosis (HP:0000991)3.14689028
28Hyperglycinemia (HP:0002154)3.04999675
29Fat malabsorption (HP:0002630)2.96151230
30Gingival bleeding (HP:0000225)2.85239110
31Combined immunodeficiency (HP:0005387)2.84463420
32Hyperglycinuria (HP:0003108)2.83923918
33Abnormality of the intrinsic pathway (HP:0010989)2.76289383
34Hypoplasia of the thymus (HP:0000778)2.74575116
35Generalized aminoaciduria (HP:0002909)2.73673066
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70675362
37Dicarboxylic aciduria (HP:0003215)2.70646572
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70646572
39Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67177586
40Abnormality of serine family amino acid metabolism (HP:0010894)2.63760221
41Abnormality of glycine metabolism (HP:0010895)2.63760221
42Cerebral palsy (HP:0100021)2.59452994
43Abnormal gallbladder physiology (HP:0012438)2.55673947
44Cholecystitis (HP:0001082)2.55673947
45Abnormality of lateral ventricle (HP:0030047)2.52527961
46Granulocytopenia (HP:0001913)2.50522443
47Nephritis (HP:0000123)2.49117457
48Steatorrhea (HP:0002570)2.47824084
49Metabolic acidosis (HP:0001942)2.46395286
50Ketosis (HP:0001946)2.46091954
51Delayed CNS myelination (HP:0002188)2.41418453
52Eosinophilia (HP:0001880)2.31456858
53Meningitis (HP:0001287)2.31361167
54Recurrent pneumonia (HP:0006532)2.29671216
55Thrombophlebitis (HP:0004418)2.29036121
56Hypochromic microcytic anemia (HP:0004840)2.26513811
57Spastic paraparesis (HP:0002313)2.25627571
58J-shaped sella turcica (HP:0002680)2.23464385
59Purpura (HP:0000979)2.16619825
60Pulmonary embolism (HP:0002204)2.14687846
61Abnormality of methionine metabolism (HP:0010901)2.09774142
62Cholelithiasis (HP:0001081)2.06925924
63Hypoalphalipoproteinemia (HP:0003233)2.03481410
64Hypoproteinemia (HP:0003075)2.02227453
65Abnormality of nucleobase metabolism (HP:0010932)2.02181742
66Hepatic necrosis (HP:0002605)1.99269937
67Autoimmune hemolytic anemia (HP:0001890)1.99144239
68Rickets (HP:0002748)1.96103187
69Abnormality of serum amino acid levels (HP:0003112)1.96100092
70Microvesicular hepatic steatosis (HP:0001414)1.95053534
71Abnormal pupillary function (HP:0007686)1.92808187
72Hepatocellular necrosis (HP:0001404)1.92579421
73Beaking of vertebral bodies (HP:0004568)1.92332358
74Hyperbilirubinemia (HP:0002904)1.92036832
75Abnormality of iron homeostasis (HP:0011031)1.90538993
76Opisthotonus (HP:0002179)1.90499371
77Abnormality of glycolipid metabolism (HP:0010969)1.90180885
78Abnormality of liposaccharide metabolism (HP:0010968)1.90180885
79Abnormality of glycosphingolipid metabolism (HP:0004343)1.90180885
80Cerebral edema (HP:0002181)1.88696153
81Abnormal gallbladder morphology (HP:0012437)1.88488881
82Verrucae (HP:0200043)1.87187114
83Papilloma (HP:0012740)1.87187114
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85955422
85Abnormality of eosinophils (HP:0001879)1.85460160
86Increased serum ferritin (HP:0003281)1.84801404
87Bile duct proliferation (HP:0001408)1.84488503
88Abnormal biliary tract physiology (HP:0012439)1.84488503
89Epidermoid cyst (HP:0200040)1.81327042
90Gangrene (HP:0100758)1.81240570
91Abnormality of the prostate (HP:0008775)1.80448316
92Skin rash (HP:0000988)1.79629603
93Abnormal enzyme/coenzyme activity (HP:0012379)1.79266192
94Death in childhood (HP:0003819)1.78595982
95Hemorrhage of the eye (HP:0011885)1.76426462
96Epistaxis (HP:0000421)1.75369364
97Glycosuria (HP:0003076)1.73745811
98Abnormality of urine glucose concentration (HP:0011016)1.73745811
99Abnormality of transition element cation homeostasis (HP:0011030)1.72805553
100Sensorimotor neuropathy (HP:0007141)1.70685509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.53084178
2BCKDK4.41272731
3VRK24.10681708
4KIT4.10545709
5TESK23.22113437
6ERN12.91328920
7FRK2.62761704
8MAP3K112.61331609
9NUAK12.47777474
10GRK62.37158981
11PIK3CG2.36530640
12SCYL22.17030278
13STK162.15951605
14FLT32.06641428
15TAF11.89601414
16MAP3K121.79274937
17KDR1.72897288
18SYK1.62901967
19BLK1.61633036
20MAP4K21.54499568
21MAP4K11.53818424
22EIF2AK11.47946193
23INSRR1.40584805
24TYK21.35913132
25CSF1R1.33098603
26CSNK1G31.24421557
27TXK1.23698468
28RPS6KB21.21901151
29ABL21.18144286
30PIK3CA1.08503837
31VRK11.07975422
32CSNK1A1L1.07958924
33MAP2K31.07554582
34GRK51.06117308
35MAPK111.02890682
36DAPK11.01799989
37RAF10.94942435
38MAP3K30.94228485
39TBK10.92379502
40SRPK10.91880815
41CSNK1G10.90332250
42BTK0.90132969
43CAMKK20.89455925
44TEC0.89004084
45EIF2AK30.88170375
46DYRK30.85646328
47MAP3K10.83352640
48MAP2K70.82996846
49MAP3K130.82478434
50CSNK1G20.81908043
51ATR0.74612776
52MAPK120.74437983
53LYN0.73507451
54MAPK130.72930002
55IRAK10.69185814
56PIM10.69129966
57MAPKAPK50.67999829
58PLK40.67040623
59BMPR1B0.65514324
60FES0.65393269
61CDK90.63678016
62TNK20.63664344
63MAP3K50.63270125
64CDK80.63006207
65CCNB10.62164197
66TLK10.60843033
67PIM20.57623544
68IGF1R0.57512386
69TAOK20.56081696
70SMG10.56046209
71DAPK20.50926499
72ZAK0.48929136
73IRAK20.48519550
74PRKAA20.46761410
75MAPKAPK30.46104434
76LCK0.44523017
77PDK20.43153364
78IKBKE0.42929879
79PINK10.41337922
80GRK10.40837562
81PRKACG0.39095800
82BRSK20.38671759
83ARAF0.35301508
84JAK30.35172236
85PLK20.33555836
86CSNK1D0.31998571
87TESK10.30983085
88IRAK40.30799082
89AKT20.29359552
90MAP2K40.29151492
91EIF2AK20.29008699
92PDK10.27723704
93DAPK30.25091347
94LRRK20.24212700
95HCK0.23308422
96PRKACA0.22946600
97CSNK2A20.22047654
98BRSK10.21380317
99MAPK40.20792468
100CSNK1A10.19102084

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.40103657
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.48105354
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29496942
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.18620773
5Retinol metabolism_Homo sapiens_hsa008303.14499011
6Complement and coagulation cascades_Homo sapiens_hsa046103.12615254
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05139721
8Drug metabolism - other enzymes_Homo sapiens_hsa009833.02937509
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.98956218
10Chemical carcinogenesis_Homo sapiens_hsa052042.78591483
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.74397868
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.73706232
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.73370714
14Fatty acid degradation_Homo sapiens_hsa000712.48359235
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36804465
16Butanoate metabolism_Homo sapiens_hsa006502.22105890
17Phenylalanine metabolism_Homo sapiens_hsa003602.17168191
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11935243
19Tryptophan metabolism_Homo sapiens_hsa003802.10118553
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.08623626
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02358363
22Arginine biosynthesis_Homo sapiens_hsa002201.89201507
23Tyrosine metabolism_Homo sapiens_hsa003501.87488633
24Peroxisome_Homo sapiens_hsa041461.78792395
25Linoleic acid metabolism_Homo sapiens_hsa005911.60794639
26Starch and sucrose metabolism_Homo sapiens_hsa005001.51723115
27Bile secretion_Homo sapiens_hsa049761.42503622
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41331361
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.39424814
30Fatty acid metabolism_Homo sapiens_hsa012121.35249149
31Histidine metabolism_Homo sapiens_hsa003401.29620794
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25601941
33Staphylococcus aureus infection_Homo sapiens_hsa051501.23714661
34Fatty acid elongation_Homo sapiens_hsa000621.23662985
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20847871
36beta-Alanine metabolism_Homo sapiens_hsa004101.19670275
37Propanoate metabolism_Homo sapiens_hsa006401.17632102
38Non-homologous end-joining_Homo sapiens_hsa034501.17628940
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17491050
40Arachidonic acid metabolism_Homo sapiens_hsa005901.09805531
41Primary immunodeficiency_Homo sapiens_hsa053401.08579342
42Biosynthesis of amino acids_Homo sapiens_hsa012301.07291065
43Carbon metabolism_Homo sapiens_hsa012001.07283264
44PPAR signaling pathway_Homo sapiens_hsa033201.01891791
45Pyruvate metabolism_Homo sapiens_hsa006201.00974353
46One carbon pool by folate_Homo sapiens_hsa006700.96596071
47Sulfur metabolism_Homo sapiens_hsa009200.86032135
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.83956421
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78697510
50Arginine and proline metabolism_Homo sapiens_hsa003300.72161493
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.72101734
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68521013
53Lysine degradation_Homo sapiens_hsa003100.66109360
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62814779
55Metabolic pathways_Homo sapiens_hsa011000.59106789
56Pentose phosphate pathway_Homo sapiens_hsa000300.58756033
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55306289
58ABC transporters_Homo sapiens_hsa020100.52928568
59Sulfur relay system_Homo sapiens_hsa041220.52624321
60Prion diseases_Homo sapiens_hsa050200.52294512
61Fat digestion and absorption_Homo sapiens_hsa049750.51395711
62DNA replication_Homo sapiens_hsa030300.50225106
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48178310
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.47803797
65Vitamin B6 metabolism_Homo sapiens_hsa007500.46981224
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45339399
67Mismatch repair_Homo sapiens_hsa034300.40990453
68Base excision repair_Homo sapiens_hsa034100.36138995
69Folate biosynthesis_Homo sapiens_hsa007900.33990806
70Homologous recombination_Homo sapiens_hsa034400.32815154
71Pyrimidine metabolism_Homo sapiens_hsa002400.32636794
72Other glycan degradation_Homo sapiens_hsa005110.28999142
73Systemic lupus erythematosus_Homo sapiens_hsa053220.28674366
74Glycerolipid metabolism_Homo sapiens_hsa005610.25336545
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20721002
76Proteasome_Homo sapiens_hsa030500.20023498
77Pertussis_Homo sapiens_hsa051330.19023670
78RNA polymerase_Homo sapiens_hsa030200.18562612
79Fatty acid biosynthesis_Homo sapiens_hsa000610.16285729
80Parkinsons disease_Homo sapiens_hsa050120.14819997
81Fanconi anemia pathway_Homo sapiens_hsa034600.13451573
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12851151
83Renin-angiotensin system_Homo sapiens_hsa046140.12736673
84Glutathione metabolism_Homo sapiens_hsa004800.11520007
85Fructose and mannose metabolism_Homo sapiens_hsa000510.11434984
86Insulin resistance_Homo sapiens_hsa049310.09103582
87Vitamin digestion and absorption_Homo sapiens_hsa049770.08910266
88Hematopoietic cell lineage_Homo sapiens_hsa046400.05463335
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03396109
90Selenocompound metabolism_Homo sapiens_hsa004500.00452965
91Nitrogen metabolism_Homo sapiens_hsa00910-0.1019868
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0797838
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0695570
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0507243
95Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0438927
96Purine metabolism_Homo sapiens_hsa00230-0.0364164
97Asthma_Homo sapiens_hsa05310-0.0361775
98Oxidative phosphorylation_Homo sapiens_hsa00190-0.0318587
99Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0244328
100Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0095851

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