AKR1C7P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)8.07484050
2N-acetylneuraminate metabolic process (GO:0006054)6.90592480
3protoporphyrinogen IX biosynthetic process (GO:0006782)6.76726739
4positive regulation of chemokine biosynthetic process (GO:0045080)5.71172719
5protoporphyrinogen IX metabolic process (GO:0046501)5.45808359
6positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.35277155
7regulation of chemokine biosynthetic process (GO:0045073)5.29942447
8amino sugar catabolic process (GO:0046348)5.26093618
9centriole replication (GO:0007099)5.15678160
10positive regulation of histone deacetylation (GO:0031065)4.81815846
11regulation of MHC class II biosynthetic process (GO:0045346)4.66685447
12positive regulation of gamma-delta T cell activation (GO:0046645)4.63952027
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39283022
14negative regulation of cell killing (GO:0031342)4.39283022
15microglial cell activation (GO:0001774)4.28677298
16negative regulation of interleukin-2 production (GO:0032703)4.28504177
17T cell migration (GO:0072678)4.16728001
18negative T cell selection (GO:0043383)4.15326821
19negative thymic T cell selection (GO:0045060)4.11096331
20positive regulation of protein deacetylation (GO:0090312)4.07558662
21modulation of growth of symbiont involved in interaction with host (GO:0044144)3.98974170
22regulation of growth of symbiont in host (GO:0044126)3.98974170
23negative regulation of growth of symbiont in host (GO:0044130)3.98974170
24negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.98974170
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98390313
26neutrophil activation involved in immune response (GO:0002283)3.97284701
27neutrophil mediated immunity (GO:0002446)3.96888196
28purine deoxyribonucleotide catabolic process (GO:0009155)3.87265922
29regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.73773900
30N-acetylglucosamine metabolic process (GO:0006044)3.66343455
31centriole assembly (GO:0098534)3.57619447
32interferon-gamma production (GO:0032609)3.56858145
33tolerance induction (GO:0002507)3.55370337
34leukocyte aggregation (GO:0070486)3.53463675
35macrophage chemotaxis (GO:0048246)3.52637893
36negative regulation of phagocytosis (GO:0050765)3.51508541
37regulation of gamma-delta T cell differentiation (GO:0045586)3.50910480
38signal complex assembly (GO:0007172)3.48383776
39negative regulation of stress fiber assembly (GO:0051497)3.45999586
40regulation of gamma-delta T cell activation (GO:0046643)3.43892019
41NIK/NF-kappaB signaling (GO:0038061)3.42468574
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.38387344
43disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.35957063
44killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.35957063
45necroptotic process (GO:0070266)3.31271329
46negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.25191957
47cellular response to interleukin-15 (GO:0071350)3.24719602
48mast cell activation (GO:0045576)3.22929913
49leukocyte degranulation (GO:0043299)3.22011381
50insulin-like growth factor receptor signaling pathway (GO:0048009)3.20763126
51macrophage activation (GO:0042116)3.20430873
52cellular response to cadmium ion (GO:0071276)3.17190345
53organelle membrane fusion (GO:0090174)3.15348080
54response to interleukin-15 (GO:0070672)3.09644431
55induction of positive chemotaxis (GO:0050930)3.08890936
56myeloid leukocyte mediated immunity (GO:0002444)3.07111506
57cytokinetic process (GO:0032506)3.06740973
58positive regulation of isotype switching (GO:0045830)3.04450751
59base-excision repair, AP site formation (GO:0006285)2.97746836
60regulation of B cell receptor signaling pathway (GO:0050855)2.97380303
61reactive oxygen species biosynthetic process (GO:1903409)2.95474517
62response to peptidoglycan (GO:0032494)2.95247569
63response to folic acid (GO:0051593)2.95197911
64alpha-beta T cell activation (GO:0046631)2.92180088
65regulation of alpha-beta T cell proliferation (GO:0046640)2.91005688
66cellular defense response (GO:0006968)2.90519147
67myeloid cell activation involved in immune response (GO:0002275)2.88885261
68positive regulation of interleukin-1 beta production (GO:0032731)2.88764088
69mature B cell differentiation involved in immune response (GO:0002313)2.88149043
70respiratory burst (GO:0045730)2.87193152
71regulation of interleukin-2 production (GO:0032663)2.86747810
72positive regulation of DNA recombination (GO:0045911)2.86224468
73programmed necrotic cell death (GO:0097300)2.86014393
74CD4-positive, alpha-beta T cell activation (GO:0035710)2.85170948
75mast cell activation involved in immune response (GO:0002279)2.85073801
76mast cell degranulation (GO:0043303)2.85073801
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.84756884
78regulation of protein import into nucleus, translocation (GO:0033158)2.84090295
79positive regulation of interleukin-1 production (GO:0032732)2.83817703
80alpha-beta T cell differentiation (GO:0046632)2.82843839
81negative regulation of execution phase of apoptosis (GO:1900118)2.82151997
82negative regulation of interleukin-12 production (GO:0032695)2.81623975
83daunorubicin metabolic process (GO:0044597)2.76147524
84polyketide metabolic process (GO:0030638)2.76147524
85doxorubicin metabolic process (GO:0044598)2.76147524
86negative regulation of T cell mediated immunity (GO:0002710)2.75496460
87regulation of necroptotic process (GO:0060544)2.75055816
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73621735
89positive regulation of granulocyte differentiation (GO:0030854)2.72608025
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72264836
91positive regulation of macrophage differentiation (GO:0045651)2.70479709
92regulation of interferon-beta biosynthetic process (GO:0045357)2.64513455
93negative regulation of interleukin-17 production (GO:0032700)2.63172266
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62535992
95neutrophil activation (GO:0042119)2.61132397
96regulation of interleukin-17 production (GO:0032660)2.59869657
97myeloid leukocyte activation (GO:0002274)2.59679036
98heme biosynthetic process (GO:0006783)2.59571593
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.59228103
100modulation by symbiont of host immune response (GO:0052553)2.59228103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.37631663
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.09703290
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.86912763
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85133898
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.60649404
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02945290
7RUNX_20019798_ChIP-Seq_JUKART_Human2.83177915
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.78627378
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76921009
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76463167
11SCL_19346495_ChIP-Seq_HPC-7_Human2.56065484
12MYB_26560356_Chip-Seq_TH2_Human2.52983444
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.49380658
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48910976
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44359555
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37339725
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.34037067
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33533136
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28983310
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28298624
21SPI1_23127762_ChIP-Seq_K562_Human2.24903536
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20658246
23SPI1_23547873_ChIP-Seq_NB4_Human2.14752128
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05001928
25MYB_26560356_Chip-Seq_TH1_Human2.04612979
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02249685
27MAF_26560356_Chip-Seq_TH1_Human1.99791442
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94048870
29VDR_24763502_ChIP-Seq_THP-1_Human1.92319182
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90312081
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.84683233
32VDR_21846776_ChIP-Seq_THP-1_Human1.78854045
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76195088
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74839896
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73737795
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.70581193
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69213968
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.65435619
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65161490
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62288726
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59015644
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58841946
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57559667
44UTX_26944678_Chip-Seq_JUKART_Human1.57210828
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55882111
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55339121
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53668090
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46513550
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45691259
50VDR_24787735_ChIP-Seq_THP-1_Human1.44445437
51GATA3_27048872_Chip-Seq_THYMUS_Human1.43464476
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.39652544
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39078515
54GATA3_26560356_Chip-Seq_TH2_Human1.38681670
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37205543
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.37085967
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35044529
58MYC_22102868_ChIP-Seq_BL_Human1.33724316
59MAF_26560356_Chip-Seq_TH2_Human1.33551894
60GATA1_19941826_ChIP-Seq_K562_Human1.33033550
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30874237
62PU_27001747_Chip-Seq_BMDM_Mouse1.30414323
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27468874
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.27420169
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25347889
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23470725
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22945854
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21573407
69NCOR1_26117541_ChIP-Seq_K562_Human1.21069101
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19420937
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16186030
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14191124
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13441942
74TFEB_21752829_ChIP-Seq_HELA_Human1.13227652
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12846961
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.11321519
77ELK1_19687146_ChIP-ChIP_HELA_Human1.07340080
78FOXP3_21729870_ChIP-Seq_TREG_Human1.06892202
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05732124
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04535536
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02366796
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.01730393
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01423786
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99326411
85GATA2_19941826_ChIP-Seq_K562_Human0.99247846
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97426484
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97027641
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96121790
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93770475
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93280111
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93085556
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89702309
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89589634
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89571103
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89549467
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89512132
97TCF7_22412390_ChIP-Seq_EML_Mouse0.88294847
98VDR_23849224_ChIP-Seq_CD4+_Human0.86932249
99KDM5A_27292631_Chip-Seq_BREAST_Human0.86427621
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86115579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.85119573
2MP0003436_decreased_susceptibility_to3.13059665
3MP0005365_abnormal_bile_salt2.83579673
4MP0006082_CNS_inflammation2.77885269
5MP0003252_abnormal_bile_duct2.75308327
6MP0003724_increased_susceptibility_to2.60730044
7MP0002419_abnormal_innate_immunity2.49695836
8MP0003763_abnormal_thymus_physiology2.45245502
9MP0001835_abnormal_antigen_presentation2.38695271
10MP0005671_abnormal_response_to2.34363976
11MP0005000_abnormal_immune_tolerance2.26616021
12MP0008961_abnormal_basal_metabolism2.24695845
13MP0009785_altered_susceptibility_to2.24535235
14MP0005025_abnormal_response_to2.19001644
15MP0004043_abnormal_pH_regulation2.16727672
16MP0003195_calcinosis2.14108429
17MP0002452_abnormal_antigen_presenting2.13062563
18MP0001800_abnormal_humoral_immune2.12089310
19MP0005464_abnormal_platelet_physiology2.09643102
20MP0002148_abnormal_hypersensitivity_rea2.07179009
21MP0002420_abnormal_adaptive_immunity2.06467207
22MP0001819_abnormal_immune_cell2.02952332
23MP0000685_abnormal_immune_system1.93375783
24MP0002723_abnormal_immune_serum1.92885668
25MP0005085_abnormal_gallbladder_physiolo1.92554917
26MP0005387_immune_system_phenotype1.91945909
27MP0001790_abnormal_immune_system1.91945909
28MP0005360_urolithiasis1.88625585
29MP0009333_abnormal_splenocyte_physiolog1.85224887
30MP0004947_skin_inflammation1.82285843
31MP0001853_heart_inflammation1.79483308
32MP0002405_respiratory_system_inflammati1.79355596
33MP0000465_gastrointestinal_hemorrhage1.75257419
34MP0005451_abnormal_body_composition1.73880103
35MP0008058_abnormal_DNA_repair1.73290776
36MP0003300_gastrointestinal_ulcer1.69742353
37MP0005167_abnormal_blood-brain_barrier1.66611425
38MP0002398_abnormal_bone_marrow1.64745109
39MP0010155_abnormal_intestine_physiology1.62877550
40MP0001845_abnormal_inflammatory_respons1.61455805
41MP0003656_abnormal_erythrocyte_physiolo1.57334104
42MP0000716_abnormal_immune_system1.56211497
43MP0000703_abnormal_thymus_morphology1.52229862
44MP0005670_abnormal_white_adipose1.51055600
45MP0002722_abnormal_immune_system1.47682641
46MP0001533_abnormal_skeleton_physiology1.47267257
47MP0003828_pulmonary_edema1.44847329
48MP0002139_abnormal_hepatobiliary_system1.39002059
49MP0000689_abnormal_spleen_morphology1.36095558
50MP0005310_abnormal_salivary_gland1.35240275
51MP0001873_stomach_inflammation1.34778073
52MP0003806_abnormal_nucleotide_metabolis1.34766770
53MP0009764_decreased_sensitivity_to1.30158921
54MP0000343_altered_response_to1.29504225
55MP0003448_altered_tumor_morphology1.28322757
56MP0002429_abnormal_blood_cell1.27597472
57MP0008875_abnormal_xenobiotic_pharmacok1.23237652
58MP0009840_abnormal_foam_cell1.23009545
59MP0008469_abnormal_protein_level1.18228371
60MP0001545_abnormal_hematopoietic_system1.13628656
61MP0005397_hematopoietic_system_phenotyp1.13628656
62MP0002877_abnormal_melanocyte_morpholog1.13204218
63MP0005164_abnormal_response_to1.12402796
64MP0003191_abnormal_cellular_cholesterol1.11238253
65MP0003303_peritoneal_inflammation1.10912192
66MP0009115_abnormal_fat_cell1.10713215
67MP0003091_abnormal_cell_migration1.05535466
68MP0010329_abnormal_lipoprotein_level1.05033434
69MP0009763_increased_sensitivity_to1.04141734
70MP0004130_abnormal_muscle_cell1.03066987
71MP0006054_spinal_hemorrhage1.01970890
72MP0009278_abnormal_bone_marrow1.00710426
73MP0005166_decreased_susceptibility_to0.94797983
74MP0008057_abnormal_DNA_replication0.92790828
75MP0004510_myositis0.90030478
76MP0002998_abnormal_bone_remodeling0.89834588
77MP0003866_abnormal_defecation0.89255543
78MP0003453_abnormal_keratinocyte_physiol0.86923876
79MP0002396_abnormal_hematopoietic_system0.86513826
80MP0000858_altered_metastatic_potential0.84526606
81MP0002132_abnormal_respiratory_system0.84182139
82MP0000003_abnormal_adipose_tissue0.84024990
83MP0000249_abnormal_blood_vessel0.83203600
84MP0002019_abnormal_tumor_incidence0.82930128
85MP0002933_joint_inflammation0.82734287
86MP0003786_premature_aging0.80552417
87MP0003172_abnormal_lysosome_physiology0.79972230
88MP0008007_abnormal_cellular_replicative0.79753635
89MP0009643_abnormal_urine_homeostasis0.78960280
90MP0009765_abnormal_xenobiotic_induced0.78466795
91MP0005058_abnormal_lysosome_morphology0.77200277
92MP0003959_abnormal_lean_body0.76740440
93MP0002332_abnormal_exercise_endurance0.74858380
94MP0002136_abnormal_kidney_physiology0.72859750
95MP0005334_abnormal_fat_pad0.71645084
96MP0005023_abnormal_wound_healing0.71119708
97MP0005266_abnormal_metabolism0.70800556
98MP0003075_altered_response_to0.70702212
99MP0005410_abnormal_fertilization0.70560218
100MP0000609_abnormal_liver_physiology0.69243966

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.75331372
2Elevated erythrocyte sedimentation rate (HP:0003565)4.69300698
3Eczematoid dermatitis (HP:0000976)4.37849781
4Myositis (HP:0100614)4.04305339
5T lymphocytopenia (HP:0005403)3.53067027
6Recurrent bacterial skin infections (HP:0005406)3.43658202
7Abnormality of T cell number (HP:0011839)3.37934231
8Recurrent abscess formation (HP:0002722)3.37430936
9Abnormality of macrophages (HP:0004311)3.37238292
10Autoimmune thrombocytopenia (HP:0001973)3.28952739
11Chronic obstructive pulmonary disease (HP:0006510)3.28032547
12Obstructive lung disease (HP:0006536)3.28032547
13Thrombocytosis (HP:0001894)3.26359182
14Abnormality of the prostate (HP:0008775)3.22181708
15Abnormality of liposaccharide metabolism (HP:0010968)3.18522510
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.18522510
17Abnormality of glycolipid metabolism (HP:0010969)3.18522510
18Recurrent fungal infections (HP:0002841)3.15879731
19Retrobulbar optic neuritis (HP:0100654)3.15487346
20Optic neuritis (HP:0100653)3.15487346
21Severe combined immunodeficiency (HP:0004430)3.12967292
22Chest pain (HP:0100749)3.10387901
23Abnormality of T cells (HP:0002843)3.05841300
24Orchitis (HP:0100796)3.04417241
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.00519097
26Vacuolated lymphocytes (HP:0001922)2.96153094
27Combined immunodeficiency (HP:0005387)2.89307125
28Pulmonary infiltrates (HP:0002113)2.88403275
29Autoimmune hemolytic anemia (HP:0001890)2.87278530
30Hyperlipoproteinemia (HP:0010980)2.86668056
31Pustule (HP:0200039)2.79238172
32Myocardial infarction (HP:0001658)2.76551726
33Panhypogammaglobulinemia (HP:0003139)2.73808659
34Abnormality of T cell physiology (HP:0011840)2.70733252
35Papillary thyroid carcinoma (HP:0002895)2.69022102
36Gangrene (HP:0100758)2.62334345
37Epistaxis (HP:0000421)2.56251480
38Arterial thrombosis (HP:0004420)2.56141880
39Meningitis (HP:0001287)2.53975014
40Increased cerebral lipofuscin (HP:0011813)2.53281091
41Exertional dyspnea (HP:0002875)2.52006658
42Recurrent skin infections (HP:0001581)2.49307091
43Hemoptysis (HP:0002105)2.48896613
44Generalized hyperpigmentation (HP:0007440)2.42282723
45Glomerulopathy (HP:0100820)2.42134742
46Hepatosplenomegaly (HP:0001433)2.42011640
47Cutaneous photosensitivity (HP:0000992)2.40846877
48Recurrent gram-negative bacterial infections (HP:0005420)2.38611167
49Increased serum ferritin (HP:0003281)2.37949552
50Chronic mucocutaneous candidiasis (HP:0002728)2.37855047
51Recurrent cutaneous fungal infections (HP:0011370)2.37855047
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.37692069
53Increased hepatocellular lipid droplets (HP:0006565)2.37366005
54Encephalitis (HP:0002383)2.37240356
55Vasculitis (HP:0002633)2.36985650
56Flat occiput (HP:0005469)2.36335492
57Subacute progressive viral hepatitis (HP:0006572)2.27449550
58Renal Fanconi syndrome (HP:0001994)2.25494830
59Anorexia (HP:0002039)2.22874817
60Gingival bleeding (HP:0000225)2.18437345
61Metabolic alkalosis (HP:0200114)2.18021878
62Recurrent viral infections (HP:0004429)2.17814646
63Xanthomatosis (HP:0000991)2.17545161
64Inflammation of the large intestine (HP:0002037)2.15798604
65Global brain atrophy (HP:0002283)2.15192444
66Skin rash (HP:0000988)2.14304215
67Spontaneous hematomas (HP:0007420)2.13453832
68Porencephaly (HP:0002132)2.13190437
69Loss of speech (HP:0002371)2.12543007
70Polyneuropathy (HP:0001271)2.12437985
71Leukocytosis (HP:0001974)2.10750279
72Cerebral hemorrhage (HP:0001342)2.10629649
73Thrombophlebitis (HP:0004418)2.09526359
74Mediastinal lymphadenopathy (HP:0100721)2.09475005
75Pulmonary embolism (HP:0002204)2.08743204
76Episodic fever (HP:0001954)2.07725247
77Neonatal respiratory distress (HP:0002643)2.07410600
78Fatigue (HP:0012378)2.04195074
79Urticaria (HP:0001025)2.03406816
80Keratoconjunctivitis sicca (HP:0001097)2.02844921
81Abnormality of iron homeostasis (HP:0011031)2.02358115
82Hyponatremia (HP:0002902)2.01873436
83Prostate neoplasm (HP:0100787)2.01798547
84Hypokalemic alkalosis (HP:0001949)2.01453836
85Abnormality of pyrimidine metabolism (HP:0004353)2.00208919
86Lipid accumulation in hepatocytes (HP:0006561)1.99930191
87IgG deficiency (HP:0004315)1.99013237
88Granulocytopenia (HP:0001913)1.98682224
89Increased CSF protein (HP:0002922)1.97710809
90Viral hepatitis (HP:0006562)1.97202082
91Increased intramyocellular lipid droplets (HP:0012240)1.95535532
92Hypokinesia (HP:0002375)1.94858331
93Keratoconjunctivitis (HP:0001096)1.93356262
94Gastrointestinal inflammation (HP:0004386)1.93315597
95Respiratory difficulties (HP:0002880)1.89767815
96Eosinophilia (HP:0001880)1.89512514
97Fair hair (HP:0002286)1.88971650
98Prolonged bleeding time (HP:0003010)1.87702004
99Abnormality of eosinophils (HP:0001879)1.87516965
100Petechiae (HP:0000967)1.87149770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.79178038
2CAMKK24.51810589
3TESK24.02381756
4NEK24.01202221
5SIK33.96371345
6TXK3.27218190
7TRIM283.26826859
8IRAK33.25856444
9CAMK1D2.75617838
10ERN12.49910330
11ZAP702.30629343
12TAF12.24686982
13MAP4K12.16741959
14MAP3K32.15325494
15RIPK41.77160954
16CAMKK11.72370029
17ARAF1.65150514
18SMG11.60671634
19JAK31.59982873
20VRK21.56193068
21TESK11.54385918
22MAP3K131.52933653
23CAMK1G1.52296025
24CSK1.46632455
25PRPF4B1.43105481
26KSR11.38665771
27CHUK1.35295433
28ITK1.23748541
29SYK1.20054813
30LRRK21.17960018
31TEC1.17409412
32JAK11.13400438
33TYK21.11930312
34MAP2K31.07842866
35FES1.03517671
36TAOK30.98176624
37HCK0.97293146
38BCR0.95817521
39IKBKE0.95546547
40MAP3K140.95433485
41MAP3K70.95278815
42PIK3CG0.93670829
43NUAK10.91926185
44TBK10.90970723
45IKBKB0.90429911
46LIMK10.88936703
47GRK60.86040003
48RAF10.82233574
49STK100.81295255
50MOS0.79412607
51BLK0.78820829
52BTK0.78041239
53LCK0.76529202
54IRAK40.73663495
55BMPR20.68930566
56TGFBR20.68767111
57BRSK20.66860320
58PDGFRB0.66428747
59KSR20.65429561
60TAOK20.64251443
61PIM10.63209889
62ERBB40.62607659
63PASK0.62354840
64MST40.61482725
65MATK0.59392365
66BRAF0.57991958
67FGR0.57546845
68MELK0.50646276
69PDK20.50289676
70LYN0.48840768
71CAMK10.45977314
72DDR20.45633212
73PTK2B0.45442816
74CSF1R0.43841946
75CLK10.43530455
76IRAK20.40175481
77GRK70.40163651
78KIT0.39107962
79PRKAA20.37345664
80MAP3K90.34799704
81PRKCQ0.34007004
82MAPK40.32641965
83TRPM70.32127720
84BMX0.31346199
85MARK20.31161459
86PIM20.29301593
87TTN0.27734244
88EIF2AK20.27328966
89MAP3K20.26809031
90MAPKAPK20.26118439
91IGF1R0.24259235
92MAP3K10.23748668
93CDK90.23402976
94CAMK40.23207396
95PAK40.22731113
96ADRBK20.22695364
97HIPK20.21378498
98MAP3K80.21321060
99ABL20.20513201
100YES10.18315016

Predicted pathways (KEGG)

RankGene SetZ-score
1Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.98592626
2T cell receptor signaling pathway_Homo sapiens_hsa046602.69971071
3Osteoclast differentiation_Homo sapiens_hsa043802.49745865
4Primary immunodeficiency_Homo sapiens_hsa053402.47059949
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.38563898
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.35241556
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34500119
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.24719538
9Leishmaniasis_Homo sapiens_hsa051401.93257813
10Staphylococcus aureus infection_Homo sapiens_hsa051501.90532860
11Hematopoietic cell lineage_Homo sapiens_hsa046401.85011056
12Other glycan degradation_Homo sapiens_hsa005111.81428748
13Rheumatoid arthritis_Homo sapiens_hsa053231.77798134
14Measles_Homo sapiens_hsa051621.77525375
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76546613
16Tuberculosis_Homo sapiens_hsa051521.75932121
17Lysosome_Homo sapiens_hsa041421.74442806
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.74154975
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69344081
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.68537192
21TNF signaling pathway_Homo sapiens_hsa046681.66122965
22Graft-versus-host disease_Homo sapiens_hsa053321.63528043
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54944242
24Legionellosis_Homo sapiens_hsa051341.54096924
25Malaria_Homo sapiens_hsa051441.49968632
26B cell receptor signaling pathway_Homo sapiens_hsa046621.49932264
27Thyroid cancer_Homo sapiens_hsa052161.47745904
28Allograft rejection_Homo sapiens_hsa053301.47055523
29Phagosome_Homo sapiens_hsa041451.45529020
30Pertussis_Homo sapiens_hsa051331.36078322
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35623763
32Autoimmune thyroid disease_Homo sapiens_hsa053201.32982753
33Shigellosis_Homo sapiens_hsa051311.32799392
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.32455198
35Sulfur metabolism_Homo sapiens_hsa009201.31736395
36Acute myeloid leukemia_Homo sapiens_hsa052211.30900906
37Chemokine signaling pathway_Homo sapiens_hsa040621.27292226
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25042802
39Hepatitis B_Homo sapiens_hsa051611.24608672
40Selenocompound metabolism_Homo sapiens_hsa004501.24028245
41Viral carcinogenesis_Homo sapiens_hsa052031.22754553
42Renin-angiotensin system_Homo sapiens_hsa046141.19596741
43Influenza A_Homo sapiens_hsa051641.18928928
44Toxoplasmosis_Homo sapiens_hsa051451.17993925
45Antigen processing and presentation_Homo sapiens_hsa046121.15544325
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14342831
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12578717
48Apoptosis_Homo sapiens_hsa042101.11552795
49Non-small cell lung cancer_Homo sapiens_hsa052231.07653933
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99884709
51Herpes simplex infection_Homo sapiens_hsa051680.99679492
52Platelet activation_Homo sapiens_hsa046110.98045129
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96837573
54Pancreatic cancer_Homo sapiens_hsa052120.95857581
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94468109
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93094774
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92879945
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91118255
59Epstein-Barr virus infection_Homo sapiens_hsa051690.87454474
60Caffeine metabolism_Homo sapiens_hsa002320.87007523
61Complement and coagulation cascades_Homo sapiens_hsa046100.85135170
62African trypanosomiasis_Homo sapiens_hsa051430.84893752
63Basal transcription factors_Homo sapiens_hsa030220.83990978
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.81037908
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.80136989
66Salmonella infection_Homo sapiens_hsa051320.79351651
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79286833
68Type I diabetes mellitus_Homo sapiens_hsa049400.77508097
69VEGF signaling pathway_Homo sapiens_hsa043700.76309406
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.75124102
71Amoebiasis_Homo sapiens_hsa051460.75041884
72Hepatitis C_Homo sapiens_hsa051600.71778531
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.70081630
74Starch and sucrose metabolism_Homo sapiens_hsa005000.68455400
75Viral myocarditis_Homo sapiens_hsa054160.62925806
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61920292
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.61675679
78Inositol phosphate metabolism_Homo sapiens_hsa005620.60699962
79HIF-1 signaling pathway_Homo sapiens_hsa040660.58654755
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55966198
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51609068
82Chronic myeloid leukemia_Homo sapiens_hsa052200.50825653
83HTLV-I infection_Homo sapiens_hsa051660.50617385
84FoxO signaling pathway_Homo sapiens_hsa040680.48749512
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45812472
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44883740
87Galactose metabolism_Homo sapiens_hsa000520.42597398
88Bladder cancer_Homo sapiens_hsa052190.41324431
89Vibrio cholerae infection_Homo sapiens_hsa051100.40960693
90ErbB signaling pathway_Homo sapiens_hsa040120.39178481
91Renal cell carcinoma_Homo sapiens_hsa052110.35789573
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35043974
93Prion diseases_Homo sapiens_hsa050200.34319376
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33405502
95Base excision repair_Homo sapiens_hsa034100.30201330
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29845017
97Colorectal cancer_Homo sapiens_hsa052100.29294495
98Glycerolipid metabolism_Homo sapiens_hsa005610.28988779
99Sphingolipid metabolism_Homo sapiens_hsa006000.26660458
100Collecting duct acid secretion_Homo sapiens_hsa049660.26179618

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