ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	6.63545799
2	nuclear pore organization (GO:0006999)	5.80260867
3	atrioventricular valve morphogenesis (GO:0003181)	5.68312766
4	DNA replication checkpoint (GO:0000076)	4.85416371
5	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	4.77519446
6	pore complex assembly (GO:0046931)	4.71760137
7	DNA duplex unwinding (GO:0032508)	4.64227235
8	DNA unwinding involved in DNA replication (GO:0006268)	4.55151654
9	DNA replication initiation (GO:0006270)	4.50289154
10	DNA geometric change (GO:0032392)	4.45987195
11	DNA strand elongation (GO:0022616)	4.28279324
12	DNA strand elongation involved in DNA replication (GO:0006271)	4.27409052
13	regulation of DNA damage checkpoint (GO:2000001)	4.19691890
14	regulation of RNA export from nucleus (GO:0046831)	4.19607665
15	homocysteine metabolic process (GO:0050667)	4.16965024
16	positive regulation of osteoblast proliferation (GO:0033690)	4.08030149
17	regulation of centriole replication (GO:0046599)	4.05512128
18	mitochondrial DNA metabolic process (GO:0032042)	4.03248558
19	regulation of translational fidelity (GO:0006450)	4.02283353
20	mitotic chromosome condensation (GO:0007076)	3.95857854
21	cellular protein complex localization (GO:0034629)	3.93919097
22	telomere maintenance via semi-conservative replication (GO:0032201)	3.91953334
23	L-serine metabolic process (GO:0006563)	3.82628816
24	telomere maintenance via recombination (GO:0000722)	3.80120635
25	mitotic sister chromatid segregation (GO:0000070)	3.79465906
26	pre-miRNA processing (GO:0031054)	3.76465987
27	DNA synthesis involved in DNA repair (GO:0000731)	3.75931766
28	glutamine metabolic process (GO:0006541)	3.71477943
29	TOR signaling (GO:0031929)	3.65507204
30	sister chromatid segregation (GO:0000819)	3.54000393
31	DNA conformation change (GO:0071103)	3.52004841
32	cell migration involved in sprouting angiogenesis (GO:0002042)	3.50209019
33	protein complex localization (GO:0031503)	3.49025904
34	mitotic sister chromatid cohesion (GO:0007064)	3.44530111
35	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.42123408
36	negative regulation of histone methylation (GO:0031061)	3.38870603
37	mitotic nuclear envelope disassembly (GO:0007077)	3.38224127
38	mitotic recombination (GO:0006312)	3.37274169
39	regulation of centrosome duplication (GO:0010824)	3.36612151
40	DNA topological change (GO:0006265)	3.34859069
41	regulation of nucleobase-containing compound transport (GO:0032239)	3.32105108
42	tRNA methylation (GO:0030488)	3.31139912
43	urea cycle (GO:0000050)	3.27259433
44	regulation of cell proliferation involved in kidney development (GO:1901722)	3.24724960
45	membrane disassembly (GO:0030397)	3.22870733
46	nuclear envelope disassembly (GO:0051081)	3.22870733
47	nitrogen cycle metabolic process (GO:0071941)	3.17651940
48	negative regulation of mRNA metabolic process (GO:1903312)	3.17524756
49	regulation of cell cycle checkpoint (GO:1901976)	3.16417562
50	regulation of histone H3-K9 methylation (GO:0051570)	3.15037476
51	viral mRNA export from host cell nucleus (GO:0046784)	3.14506309
52	positive regulation of cell cycle checkpoint (GO:1901978)	3.13288767
53	glucocorticoid receptor signaling pathway (GO:0042921)	3.12170635
54	apoptotic process involved in morphogenesis (GO:0060561)	3.11274245
55	heterochromatin organization (GO:0070828)	3.10962086
56	regulation of centrosome cycle (GO:0046605)	3.10295634
57	L-alpha-amino acid transmembrane transport (GO:1902475)	3.08900370
58	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.06060477
59	regulation of hippo signaling (GO:0035330)	3.01445194
60	DNA biosynthetic process (GO:0071897)	3.01072683
61	midgut development (GO:0007494)	3.00351654
62	peptidyl-lysine dimethylation (GO:0018027)	2.98373110
63	blood vessel endothelial cell migration (GO:0043534)	2.97665876
64	atrial septum morphogenesis (GO:0060413)	2.97571566
65	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.96136100
66	DNA replication-dependent nucleosome organization (GO:0034723)	2.95552659
67	DNA replication-dependent nucleosome assembly (GO:0006335)	2.95552659
68	negative regulation of mRNA processing (GO:0050686)	2.92707654
69	pericardium development (GO:0060039)	2.89058454
70	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.89047046
71	formation of translation preinitiation complex (GO:0001731)	2.88615880
72	nucleosome disassembly (GO:0006337)	2.87340944
73	protein-DNA complex disassembly (GO:0032986)	2.87340944
74	double-strand break repair via nonhomologous end joining (GO:0006303)	2.87280841
75	non-recombinational repair (GO:0000726)	2.87280841
76	folic acid metabolic process (GO:0046655)	2.87138421
77	corticosteroid receptor signaling pathway (GO:0031958)	2.85849626
78	nuclear envelope organization (GO:0006998)	2.85566852
79	positive regulation of p38MAPK cascade (GO:1900745)	2.85559211
80	urea metabolic process (GO:0019627)	2.85270522
81	ribosome biogenesis (GO:0042254)	2.85185646
82	translesion synthesis (GO:0019985)	2.84553857
83	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.84510746
84	histone arginine methylation (GO:0034969)	2.81506327
85	positive regulation of odontogenesis (GO:0042482)	2.81331612
86	regulation of NFAT protein import into nucleus (GO:0051532)	2.81208593
87	dosage compensation (GO:0007549)	2.80506486
88	regulation of monocyte differentiation (GO:0045655)	2.79982614
89	positive regulation by host of viral transcription (GO:0043923)	2.78894482
90	peptidyl-arginine omega-N-methylation (GO:0035247)	2.77591219
91	telomere maintenance (GO:0000723)	2.76742991
92	low-density lipoprotein particle clearance (GO:0034383)	2.76221963
93	telomere organization (GO:0032200)	2.74383169
94	rRNA transcription (GO:0009303)	2.73102173
95	meiotic chromosome segregation (GO:0045132)	2.72728262
96	mitochondrial RNA metabolic process (GO:0000959)	2.72058894
97	monoubiquitinated protein deubiquitination (GO:0035520)	2.69564317
98	dorsal/ventral axis specification (GO:0009950)	2.68657655
99	protein localization to chromosome, centromeric region (GO:0071459)	2.66503661
100	regulation of spindle checkpoint (GO:0090231)	2.66416364

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.68818992
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.93454302
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.56782661
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.38226386
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.29474258
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.27104453
7	MYC_22102868_ChIP-Seq_BL_Human	2.92583521
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.92174055
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.55884337
10	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.40369226
11	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.36874244
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.27753233
13	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.12276009
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.10976872
15	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.02789679
16	E2F7_22180533_ChIP-Seq_HELA_Human	10.1677344
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.97013239
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.96996511
19	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87880586
20	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.86285511
21	GATA1_22025678_ChIP-Seq_K562_Human	1.85980911
22	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.78493888
23	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.70800026
24	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.70294662
25	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.70009215
26	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.68772796
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.65154911
28	KDM5A_27292631_Chip-Seq_BREAST_Human	1.64732542
29	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.62655134
30	AR_21909140_ChIP-Seq_LNCAP_Human	1.62285247
31	VDR_21846776_ChIP-Seq_THP-1_Human	1.61253305
32	CIITA_25753668_ChIP-Seq_RAJI_Human	1.55092308
33	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.54254429
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.53185731
35	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.52786229
36	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.51248194
37	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.49584987
38	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.47994752
39	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.45301520
40	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.43154315
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40111316
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.36688466
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31594024
44	TCF7_22412390_ChIP-Seq_EML_Mouse	1.26422147
45	TFEB_21752829_ChIP-Seq_HELA_Human	1.25422753
46	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.21248838
47	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.20711056
48	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18824013
49	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.18481001
50	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.18197943
51	CLOCK_20551151_ChIP-Seq_293T_Human	1.17585221
52	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16150764
53	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15368391
54	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.13362863
55	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12531902
56	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10851613
57	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.10787014
58	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.08932254
59	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.08598248
60	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.07520073
61	ATF3_27146783_Chip-Seq_COLON_Human	1.05586296
62	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.04318662
63	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.04058239
64	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03361927
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03131637
66	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.01937387
67	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.01312565
68	NCOR1_26117541_ChIP-Seq_K562_Human	1.01043193
69	KDM2B_26808549_Chip-Seq_DND41_Human	1.00758865
70	RACK7_27058665_Chip-Seq_MCF-7_Human	1.00742166
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.99790904
72	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.98576961
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.97678435
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97657176
75	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97395026
76	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97121594
77	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96394205
78	GABP_19822575_ChIP-Seq_HepG2_Human	0.94907992
79	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94474791
80	CHD1_26751641_Chip-Seq_LNCaP_Human	0.94093721
81	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.92180198
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.92085118
83	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.91720875
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91622514
85	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.90313640
86	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89912226
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89794635
88	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.88944404
89	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.87052822
90	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.86847903
91	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.86768868
92	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.86768868
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86072936
94	FOXP3_21729870_ChIP-Seq_TREG_Human	0.84044943
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.83938629
96	MAF_26560356_Chip-Seq_TH1_Human	0.83607644
97	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.81731136
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.81506176
99	GATA6_25053715_ChIP-Seq_YYC3_Human	0.80912439
100	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.79818769

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	6.57680533
2	MP0010094_abnormal_chromosome_stability	4.11897409
3	MP0008057_abnormal_DNA_replication	3.93206942
4	MP0003111_abnormal_nucleus_morphology	3.74636025
5	MP0005076_abnormal_cell_differentiation	3.57700603
6	MP0004233_abnormal_muscle_weight	3.41487314
7	MP0002396_abnormal_hematopoietic_system	2.92616911
8	MP0003693_abnormal_embryo_hatching	2.88922540
9	MP0003077_abnormal_cell_cycle	2.85294004
10	MP0008058_abnormal_DNA_repair	2.57701689
11	MP0004808_abnormal_hematopoietic_stem	2.53828017
12	MP0004957_abnormal_blastocyst_morpholog	2.51784358
13	MP0008932_abnormal_embryonic_tissue	2.16186578
14	MP0002089_abnormal_postnatal_growth/wei	2.13553981
15	MP0002009_preneoplasia	2.10315944
16	MP0005220_abnormal_exocrine_pancreas	2.07037719
17	MP0010307_abnormal_tumor_latency	2.05896599
18	MP0003705_abnormal_hypodermis_morpholog	1.88035917
19	MP0010352_gastrointestinal_tract_polyps	1.84889625
20	MP0001661_extended_life_span	1.81359158
21	MP0003984_embryonic_growth_retardation	1.80709363
22	MP0003786_premature_aging	1.79020401
23	MP0000003_abnormal_adipose_tissue	1.77830629
24	MP0001730_embryonic_growth_arrest	1.75294533
25	MP0002088_abnormal_embryonic_growth/wei	1.73364130
26	MP0000350_abnormal_cell_proliferation	1.71397734
27	MP0008007_abnormal_cellular_replicative	1.62425540
28	MP0001672_abnormal_embryogenesis/_devel	1.62357437
29	MP0005380_embryogenesis_phenotype	1.62357437
30	MP0009672_abnormal_birth_weight	1.54032675
31	MP0002697_abnormal_eye_size	1.51582037
32	MP0002086_abnormal_extraembryonic_tissu	1.49817552
33	MP0002938_white_spotting	1.49689843
34	MP0002080_prenatal_lethality	1.38964358
35	MP0002084_abnormal_developmental_patter	1.37817478
36	MP0001697_abnormal_embryo_size	1.34768584
37	MP0003566_abnormal_cell_adhesion	1.34274449
38	MP0003937_abnormal_limbs/digits/tail_de	1.28761148
39	MP0000579_abnormal_nail_morphology	1.28020569
40	MP0004197_abnormal_fetal_growth/weight/	1.23804243
41	MP0002108_abnormal_muscle_morphology	1.23674527
42	MP0009278_abnormal_bone_marrow	1.23523669
43	MP0009840_abnormal_foam_cell	1.23134116
44	MP0003890_abnormal_embryonic-extraembry	1.17565072
45	MP0005197_abnormal_uvea_morphology	1.16701465
46	MP0000313_abnormal_cell_death	1.15289737
47	MP0002111_abnormal_tail_morphology	1.14184314
48	MP0002085_abnormal_embryonic_tissue	1.09921211
49	MP0005621_abnormal_cell_physiology	1.09803603
50	MP0001849_ear_inflammation	1.08658630
51	MP0002877_abnormal_melanocyte_morpholog	1.07773604
52	MP0003959_abnormal_lean_body	1.07441106
53	MP0000733_abnormal_muscle_development	1.07289696
54	MP0000537_abnormal_urethra_morphology	1.06333663
55	MP0009703_decreased_birth_body	1.01238817
56	MP0000013_abnormal_adipose_tissue	0.98067771
57	MP0003718_maternal_effect	0.96402345
58	MP0003453_abnormal_keratinocyte_physiol	0.93884054
59	MP0000490_abnormal_crypts_of	0.91187638
60	MP0009697_abnormal_copulation	0.90781463
61	MP0002332_abnormal_exercise_endurance	0.89994856
62	MP0002269_muscular_atrophy	0.89335344
63	MP0000428_abnormal_craniofacial_morphol	0.88558279
64	MP0005384_cellular_phenotype	0.88395785
65	MP0002970_abnormal_white_adipose	0.86630040
66	MP0000383_abnormal_hair_follicle	0.84803416
67	MP0003567_abnormal_fetal_cardiomyocyte	0.84770253
68	MP0010030_abnormal_orbit_morphology	0.84433702
69	MP0008770_decreased_survivor_rate	0.84308220
70	MP0004185_abnormal_adipocyte_glucose	0.83238311
71	MP0002019_abnormal_tumor_incidence	0.82044643
72	MP0000358_abnormal_cell_content/	0.81783005
73	MP0010630_abnormal_cardiac_muscle	0.79413833
74	MP0008961_abnormal_basal_metabolism	0.79048706
75	MP0005375_adipose_tissue_phenotype	0.78754508
76	MP0003763_abnormal_thymus_physiology	0.77855804
77	MP0005501_abnormal_skin_physiology	0.77656197
78	MP0006138_congestive_heart_failure	0.76891296
79	MP0000759_abnormal_skeletal_muscle	0.75563284
80	MP0008995_early_reproductive_senescence	0.74038303
81	MP0002092_abnormal_eye_morphology	0.73747239
82	MP0003950_abnormal_plasma_membrane	0.71648834
83	MP0001286_abnormal_eye_development	0.70926578
84	MP0004087_abnormal_muscle_fiber	0.70901598
85	MP0003091_abnormal_cell_migration	0.70200426
86	MP0003699_abnormal_female_reproductive	0.68833754
87	MP0000049_abnormal_middle_ear	0.67377549
88	MP0000432_abnormal_head_morphology	0.65540076
89	MP0003115_abnormal_respiratory_system	0.64650177
90	MP0010678_abnormal_skin_adnexa	0.64238209
91	MP0002060_abnormal_skin_morphology	0.64145414
92	MP0005334_abnormal_fat_pad	0.63704208
93	MP0000598_abnormal_liver_morphology	0.61487996
94	MP0002796_impaired_skin_barrier	0.58388934
95	MP0002925_abnormal_cardiovascular_devel	0.58033658
96	MP0001348_abnormal_lacrimal_gland	0.57963538
97	MP0006035_abnormal_mitochondrial_morpho	0.57880656
98	MP0003935_abnormal_craniofacial_develop	0.57406851
99	MP0003941_abnormal_skin_development	0.56621055
100	MP0001243_abnormal_dermal_layer	0.56381705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.67398992
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.38648168
3	Progressive muscle weakness (HP:0003323)	4.09685097
4	Chromsome breakage (HP:0040012)	3.82616416
5	Dysmetric saccades (HP:0000641)	3.59643887
6	Abnormality of the nasal septum (HP:0000419)	3.36349447
7	Broad face (HP:0000283)	3.03786547
8	Duplicated collecting system (HP:0000081)	2.96972811
9	Central scotoma (HP:0000603)	2.92050998
10	Lip pit (HP:0100267)	2.89740732
11	Urethral obstruction (HP:0000796)	2.89442673
12	Progressive external ophthalmoplegia (HP:0000590)	2.78170359
13	Depressed nasal tip (HP:0000437)	2.77005664
14	Ragged-red muscle fibers (HP:0003200)	2.76166961
15	Homocystinuria (HP:0002156)	2.74373661
16	Abnormality of homocysteine metabolism (HP:0010919)	2.74373661
17	Birth length less than 3rd percentile (HP:0003561)	2.72048614
18	Ulnar bowing (HP:0003031)	2.67496316
19	Ectopic kidney (HP:0000086)	2.61626527
20	Breast hypoplasia (HP:0003187)	2.61435013
21	Ankyloglossia (HP:0010296)	2.52731406
22	Abnormality of the fingertips (HP:0001211)	2.45286285
23	Sandal gap (HP:0001852)	2.44372862
24	Abnormality of cochlea (HP:0000375)	2.43792790
25	Abnormality of the calcaneus (HP:0008364)	2.42898377
26	Aplasia cutis congenita (HP:0001057)	2.42414663
27	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.41439967
28	Absent radius (HP:0003974)	2.40103447
29	Hyperacusis (HP:0010780)	2.39965216
30	Duplication of thumb phalanx (HP:0009942)	2.36892780
31	Abnormality of the renal collecting system (HP:0004742)	2.33712521
32	Calcaneovalgus deformity (HP:0001848)	2.32719655
33	Deviation of the thumb (HP:0009603)	2.32408178
34	Long eyelashes (HP:0000527)	2.29708688
35	Prominent nose (HP:0000448)	2.29020619
36	Sparse lateral eyebrow (HP:0005338)	2.27750786
37	Aplasia of the musculature (HP:0100854)	2.22399364
38	Sensory axonal neuropathy (HP:0003390)	2.22380985
39	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.21828571
40	Abnormality of DNA repair (HP:0003254)	2.18659701
41	Absent forearm bone (HP:0003953)	2.17941099
42	Aplasia involving forearm bones (HP:0009822)	2.17941099
43	Squamous cell carcinoma (HP:0002860)	2.16418479
44	Ureteral duplication (HP:0000073)	2.12932081
45	Short thumb (HP:0009778)	2.11058596
46	Abnormality of oral frenula (HP:0000190)	2.10212685
47	Cerebellar dysplasia (HP:0007033)	2.10188809
48	Thin ribs (HP:0000883)	2.06008940
49	Scotoma (HP:0000575)	2.02604641
50	Proximal placement of thumb (HP:0009623)	2.02205404
51	Abnormality of chromosome stability (HP:0003220)	2.00876190
52	Meckel diverticulum (HP:0002245)	1.99924971
53	Abnormality of the ileum (HP:0001549)	1.99817618
54	Abnormality of the carotid arteries (HP:0005344)	1.97766949
55	Abnormality of the preputium (HP:0100587)	1.97686396
56	Intestinal fistula (HP:0100819)	1.97332119
57	Anal stenosis (HP:0002025)	1.97165870
58	Hypergonadotropic hypogonadism (HP:0000815)	1.94925188
59	Patellar aplasia (HP:0006443)	1.94640483
60	Abnormal number of incisors (HP:0011064)	1.92097710
61	Milia (HP:0001056)	1.91477190
62	Multiple enchondromatosis (HP:0005701)	1.91401386
63	Nasolacrimal duct obstruction (HP:0000579)	1.87767470
64	Elbow flexion contracture (HP:0002987)	1.87131731
65	2-3 toe syndactyly (HP:0004691)	1.86288447
66	Premature ovarian failure (HP:0008209)	1.86062056
67	Persistence of primary teeth (HP:0006335)	1.85601141
68	Deformed tarsal bones (HP:0008119)	1.83783175
69	Natal tooth (HP:0000695)	1.82219256
70	Fair hair (HP:0002286)	1.82170611
71	Deep philtrum (HP:0002002)	1.81228936
72	Impulsivity (HP:0100710)	1.80034530
73	Abnormality of the salivary glands (HP:0010286)	1.79034059
74	Nephroblastoma (Wilms tumor) (HP:0002667)	1.77467819
75	Distal lower limb amyotrophy (HP:0008944)	1.76716169
76	Selective tooth agenesis (HP:0001592)	1.75778976
77	Esophageal atresia (HP:0002032)	1.75623525
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74282421
79	Long palpebral fissure (HP:0000637)	1.74238240
80	Clubbing of toes (HP:0100760)	1.72779179
81	Dislocated radial head (HP:0003083)	1.72144335
82	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.71783265
83	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.69833818
84	Epidermoid cyst (HP:0200040)	1.69801107
85	Sloping forehead (HP:0000340)	1.69567838
86	Dyschromatopsia (HP:0007641)	1.68698845
87	Intestinal malrotation (HP:0002566)	1.68164110
88	Subcapsular cataract (HP:0000523)	1.66446249
89	Reticulocytopenia (HP:0001896)	1.66001301
90	Spina bifida occulta (HP:0003298)	1.65732265
91	Increased connective tissue (HP:0009025)	1.65621030
92	Cutis marmorata (HP:0000965)	1.63546194
93	Preauricular skin tag (HP:0000384)	1.63189252
94	Short chin (HP:0000331)	1.62042879
95	Small intestinal stenosis (HP:0012848)	1.61817585
96	Duodenal stenosis (HP:0100867)	1.61817585
97	Abnormality of pyrimidine metabolism (HP:0004353)	1.61636163
98	External ophthalmoplegia (HP:0000544)	1.60135111
99	Abnormality of the lacrimal duct (HP:0011481)	1.59635244
100	Relative macrocephaly (HP:0004482)	1.58310106

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIM2	5.97564169
2	ICK	4.94845665
3	CDK12	4.64891344
4	PDK2	4.43458935
5	RAF1	3.18643245
6	TLK1	2.84816236
7	EEF2K	2.84481448
8	CDC7	2.82736405
9	ZAK	2.33079391
10	BRD4	2.22058935
11	MTOR	2.12613242
12	MAP3K10	2.09103642
13	SMG1	2.02113957
14	CAMK1D	1.86333703
15	PIM1	1.84957906
16	MAPK11	1.80534590
17	TRIB3	1.80392896
18	SRPK1	1.65386916
19	MST1R	1.59376779
20	PAK2	1.50593970
21	NME1	1.40527229
22	MAP3K7	1.38038621
23	RPS6KA5	1.35814790
24	TTN	1.32969212
25	CAMK1G	1.32809825
26	AKT3	1.29290649
27	TTK	1.22250234
28	CHEK2	1.21070701
29	PBK	1.20793426
30	MKNK2	1.16166366
31	NEK6	1.11816333
32	RPS6KB2	1.11074212
33	MET	0.98464612
34	ATR	0.97846878
35	CHEK1	0.97598371
36	AURKB	0.96687607
37	LATS2	0.94880717
38	STK39	0.93491743
39	AURKA	0.91495028
40	MKNK1	0.90197488
41	WNK4	0.88405748
42	PRPF4B	0.84521506
43	CDK7	0.84128173
44	BUB1	0.83869993
45	PRKAA1	0.82711962
46	RPS6KA1	0.78589907
47	CDK4	0.77437221
48	LATS1	0.75802086
49	CDK2	0.67952886
50	RPS6KC1	0.66152988
51	RPS6KL1	0.66152988
52	TSSK6	0.65417473
53	EPHA2	0.65246287
54	ACVR1B	0.64086481
55	MAP3K8	0.59670479
56	GSK3A	0.59309498
57	PLK1	0.58940614
58	BRSK2	0.58605188
59	SCYL2	0.55428902
60	VRK1	0.55402782
61	ATM	0.54874888
62	MELK	0.53763290
63	RPS6KA6	0.53700895
64	CDK8	0.53565451
65	CDK6	0.52561769
66	CDK1	0.52391687
67	MARK2	0.46937007
68	NEK2	0.46512424
69	GSK3B	0.46024294
70	MAPK14	0.45668718
71	MAPK10	0.45037634
72	MAPK1	0.42734936
73	PASK	0.42672306
74	NME2	0.42397880
75	MAP2K2	0.40612309
76	BMX	0.40430630
77	MAPK12	0.40247078
78	PKN2	0.37252376
79	CDK9	0.37040289
80	TRPM7	0.36374312
81	AKT1	0.35624998
82	ERBB4	0.35584430
83	IRAK3	0.35533766
84	MAP2K3	0.35490158
85	WEE1	0.31848018
86	TAOK2	0.31720719
87	PTK2	0.30835139
88	SIK1	0.30504807
89	MAPK7	0.30425875
90	OXSR1	0.30356371
91	PRKDC	0.30178460
92	TGFBR1	0.29504799
93	BMPR1B	0.28809690
94	MAPK9	0.28416151
95	MAPK8	0.27435831
96	PRKAA2	0.27211263
97	CSNK1A1L	0.27164862
98	PLK4	0.26133169
99	STK4	0.24251596
100	MAPK3	0.24149328

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.16350615
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.40215484
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.32777978
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.73355241
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.54412363
6	Cell cycle_Homo sapiens_hsa04110	2.52593282
7	Mismatch repair_Homo sapiens_hsa03430	2.48192101
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.40983058
9	Base excision repair_Homo sapiens_hsa03410	2.40223620
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.39953101
11	Alcoholism_Homo sapiens_hsa05034	2.33181086
12	Homologous recombination_Homo sapiens_hsa03440	2.19403165
13	Thyroid cancer_Homo sapiens_hsa05216	2.16844138
14	One carbon pool by folate_Homo sapiens_hsa00670	2.02760165
15	RNA transport_Homo sapiens_hsa03013	2.01614808
16	mRNA surveillance pathway_Homo sapiens_hsa03015	2.01119898
17	Small cell lung cancer_Homo sapiens_hsa05222	2.00405971
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.95650761
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.86257645
20	Lysine degradation_Homo sapiens_hsa00310	1.81995745
21	Bladder cancer_Homo sapiens_hsa05219	1.75204828
22	Spliceosome_Homo sapiens_hsa03040	1.73112618
23	MicroRNAs in cancer_Homo sapiens_hsa05206	1.67047216
24	Viral carcinogenesis_Homo sapiens_hsa05203	1.66166500
25	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.59585412
26	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.57850951
27	RNA polymerase_Homo sapiens_hsa03020	1.53800700
28	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.49608614
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.44578223
30	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.41081936
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.39835439
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32613376
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.30951841
34	Sulfur relay system_Homo sapiens_hsa04122	1.05716057
35	Endometrial cancer_Homo sapiens_hsa05213	1.05607906
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05512082
37	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.04391738
38	Other glycan degradation_Homo sapiens_hsa00511	1.03920357
39	Acute myeloid leukemia_Homo sapiens_hsa05221	1.03835491
40	Colorectal cancer_Homo sapiens_hsa05210	1.03065010
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.00525689
42	Adherens junction_Homo sapiens_hsa04520	0.97809470
43	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.92266537
44	mTOR signaling pathway_Homo sapiens_hsa04150	0.91688866
45	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.90174244
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.89577483
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89477542
48	Pentose phosphate pathway_Homo sapiens_hsa00030	0.87192481
49	p53 signaling pathway_Homo sapiens_hsa04115	0.85649406
50	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.83494633
51	RNA degradation_Homo sapiens_hsa03018	0.81504528
52	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80980817
53	Purine metabolism_Homo sapiens_hsa00230	0.80154142
54	HTLV-I infection_Homo sapiens_hsa05166	0.77502471
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77400756
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76166036
57	Carbon metabolism_Homo sapiens_hsa01200	0.71747250
58	Non-small cell lung cancer_Homo sapiens_hsa05223	0.69639664
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67937175
60	Prostate cancer_Homo sapiens_hsa05215	0.67062407
61	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.66408259
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63906129
63	Pancreatic cancer_Homo sapiens_hsa05212	0.61835838
64	AMPK signaling pathway_Homo sapiens_hsa04152	0.60523895
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.59798933
66	Insulin signaling pathway_Homo sapiens_hsa04910	0.59662367
67	ErbB signaling pathway_Homo sapiens_hsa04012	0.57981759
68	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57919273
69	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.56473970
70	Basal transcription factors_Homo sapiens_hsa03022	0.55290157
71	Folate biosynthesis_Homo sapiens_hsa00790	0.53755295
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.52904878
73	Apoptosis_Homo sapiens_hsa04210	0.52552673
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.51872566
75	Insulin resistance_Homo sapiens_hsa04931	0.51354879
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.51346491
77	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.48534948
78	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47005888
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.45873692
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.45214167
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45196091
82	Herpes simplex infection_Homo sapiens_hsa05168	0.44974594
83	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.43410758
84	Pathways in cancer_Homo sapiens_hsa05200	0.42748703
85	Hepatitis B_Homo sapiens_hsa05161	0.40944976
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.40810162
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40529867
88	Notch signaling pathway_Homo sapiens_hsa04330	0.37223019
89	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.37112366
90	Wnt signaling pathway_Homo sapiens_hsa04310	0.36892286
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.33310205
92	Oocyte meiosis_Homo sapiens_hsa04114	0.32776455
93	ECM-receptor interaction_Homo sapiens_hsa04512	0.32342570
94	ABC transporters_Homo sapiens_hsa02010	0.28019539
95	Glioma_Homo sapiens_hsa05214	0.25469983
96	Circadian rhythm_Homo sapiens_hsa04710	0.24299995
97	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.23217979
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.22380846
99	Focal adhesion_Homo sapiens_hsa04510	0.21870091
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.21257658

AKR7A2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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