AKR7A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.49394905
2exogenous drug catabolic process (GO:0042738)7.43577457
3drug catabolic process (GO:0042737)7.18772871
4urea metabolic process (GO:0019627)6.47068692
5cellular glucuronidation (GO:0052695)6.31712907
6drug metabolic process (GO:0017144)6.29092369
7omega-hydroxylase P450 pathway (GO:0097267)6.18114729
8uronic acid metabolic process (GO:0006063)6.13563894
9glucuronate metabolic process (GO:0019585)6.13563894
10ethanol oxidation (GO:0006069)6.01283163
11urea cycle (GO:0000050)5.96181154
12nitrogen cycle metabolic process (GO:0071941)5.90807165
13intestinal absorption (GO:0050892)5.77591866
14angiotensin maturation (GO:0002003)5.68331180
15fat-soluble vitamin biosynthetic process (GO:0042362)5.57400968
16regulation of triglyceride catabolic process (GO:0010896)5.54746669
17regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.26628257
18bile acid and bile salt transport (GO:0015721)5.25037129
19intestinal cholesterol absorption (GO:0030299)5.04073772
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03876005
21L-phenylalanine catabolic process (GO:0006559)5.03876005
22complement activation, alternative pathway (GO:0006957)5.03029033
23glyoxylate metabolic process (GO:0046487)4.94224867
24hormone catabolic process (GO:0042447)4.92229823
25bile acid metabolic process (GO:0008206)4.86954892
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.85913485
27L-phenylalanine metabolic process (GO:0006558)4.85913485
28alkaloid metabolic process (GO:0009820)4.81645715
29ethanol metabolic process (GO:0006067)4.78262484
30regulation of bile acid biosynthetic process (GO:0070857)4.70004980
31NADH metabolic process (GO:0006734)4.68959696
32regulation of protein activation cascade (GO:2000257)4.65557231
33flavonoid metabolic process (GO:0009812)4.63820534
34regulation of fibrinolysis (GO:0051917)4.60706453
35negative regulation of cholesterol transport (GO:0032375)4.48793173
36negative regulation of sterol transport (GO:0032372)4.48793173
37regulation of complement activation (GO:0030449)4.45727058
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.43514285
39negative regulation of fibrinolysis (GO:0051918)4.40307600
40phenylpropanoid metabolic process (GO:0009698)4.35421370
41oxidative demethylation (GO:0070989)4.33110417
42phospholipid efflux (GO:0033700)4.30816185
43fructose metabolic process (GO:0006000)4.29529367
44positive regulation of lipoprotein lipase activity (GO:0051006)4.27178065
45positive regulation of triglyceride lipase activity (GO:0061365)4.27178065
46arginine metabolic process (GO:0006525)4.25048687
47very-low-density lipoprotein particle assembly (GO:0034379)4.23164773
48complement activation, classical pathway (GO:0006958)4.07951661
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07018652
50regulation of cholesterol esterification (GO:0010872)4.06355418
51bile acid biosynthetic process (GO:0006699)3.95452810
52digestion (GO:0007586)3.95435666
53plasma lipoprotein particle remodeling (GO:0034369)3.89091021
54protein-lipid complex remodeling (GO:0034368)3.89091021
55macromolecular complex remodeling (GO:0034367)3.89091021
56lipoprotein transport (GO:0042953)3.85067339
57complement activation (GO:0006956)3.77781576
58regulation of guanylate cyclase activity (GO:0031282)3.76940322
59high-density lipoprotein particle remodeling (GO:0034375)3.76125120
60fibrinolysis (GO:0042730)3.76014108
61protein carboxylation (GO:0018214)3.74637514
62peptidyl-glutamic acid carboxylation (GO:0017187)3.74637514
63positive regulation of lipid catabolic process (GO:0050996)3.73894425
64protein activation cascade (GO:0072376)3.67615873
65plasma lipoprotein particle assembly (GO:0034377)3.66378136
66negative regulation of digestive system process (GO:0060457)3.62404738
67drug transmembrane transport (GO:0006855)3.56417353
68lipoprotein metabolic process (GO:0042157)3.56068045
69renal system process involved in regulation of blood volume (GO:0001977)3.55713604
70cholesterol efflux (GO:0033344)3.55180220
71aromatic amino acid family catabolic process (GO:0009074)3.52183956
72negative regulation of hemostasis (GO:1900047)3.50269809
73negative regulation of blood coagulation (GO:0030195)3.50269809
74drug transport (GO:0015893)3.49194150
75primary alcohol catabolic process (GO:0034310)3.48409711
76diacylglycerol metabolic process (GO:0046339)3.48082963
77daunorubicin metabolic process (GO:0044597)3.47007520
78polyketide metabolic process (GO:0030638)3.47007520
79doxorubicin metabolic process (GO:0044598)3.47007520
80glutamine family amino acid biosynthetic process (GO:0009084)3.42424658
81acute-phase response (GO:0006953)3.40204469
82protein-lipid complex assembly (GO:0065005)3.34519280
83maintenance of gastrointestinal epithelium (GO:0030277)3.33189527
84transcytosis (GO:0045056)3.33098964
85acylglycerol homeostasis (GO:0055090)3.30295617
86triglyceride homeostasis (GO:0070328)3.30295617
87vitamin biosynthetic process (GO:0009110)3.27933027
88heme transport (GO:0015886)3.27528452
89xenobiotic metabolic process (GO:0006805)3.25975257
90amino-acid betaine metabolic process (GO:0006577)3.24633271
91blood coagulation, intrinsic pathway (GO:0007597)3.24231734
92negative regulation of coagulation (GO:0050819)3.23738219
93reverse cholesterol transport (GO:0043691)3.23003387
94plasma lipoprotein particle organization (GO:0071827)3.22695340
95proline metabolic process (GO:0006560)3.20296054
96renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.16396424
97regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.15672012
98endocrine process (GO:0050886)3.15672012
99regulation of systemic arterial blood pressure by hormone (GO:0001990)3.15672012
100cholesterol homeostasis (GO:0042632)3.15598668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.98682771
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.16737775
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.46530695
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.37745109
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.18305101
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.17494613
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.96499264
8CDX2_20551321_ChIP-Seq_CACO-2_Human3.78954243
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.85188704
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60402400
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.51684189
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.46955722
13GATA4_25053715_ChIP-Seq_YYC3_Human2.35967404
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20578396
15GATA6_25053715_ChIP-Seq_YYC3_Human2.04696428
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88158787
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.84090323
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81405952
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80281974
20SOX2_20726797_ChIP-Seq_SW620_Human1.80025701
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.79731898
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78843152
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.78653915
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74077741
25LXR_22292898_ChIP-Seq_THP-1_Human1.72789143
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.61361806
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60530634
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.53294117
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51813240
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.47063112
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46250409
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45617375
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.44347101
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44039250
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41819148
36CLOCK_20551151_ChIP-Seq_293T_Human1.37320324
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35701388
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.31691847
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31153357
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26515358
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23271027
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.19685170
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17238635
44RACK7_27058665_Chip-Seq_MCF-7_Human1.16899007
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15831622
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13431524
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12081476
48FOXA1_25552417_ChIP-Seq_VCAP_Human1.11751752
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11430823
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10891169
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.09921119
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06782306
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06686883
54GATA1_22025678_ChIP-Seq_K562_Human1.06151477
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05613918
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05069396
57* SA1_27219007_Chip-Seq_Bcells_Human1.04670114
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03031537
59CEBPB_22108803_ChIP-Seq_LS180_Human1.00315633
60TCF4_18268006_ChIP-ChIP_LS174T_Human0.99725055
61TET1_21451524_ChIP-Seq_MESCs_Mouse0.99681830
62BCOR_27268052_Chip-Seq_Bcells_Human0.99542436
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98626154
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97814424
65JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96684375
66P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95876943
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95742171
68ESR1_20079471_ChIP-ChIP_T-47D_Human0.95331181
69* CTCF_27219007_Chip-Seq_Bcells_Human0.95007934
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92447969
71* BCL6_27268052_Chip-Seq_Bcells_Human0.91736600
72* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90933258
73RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90252244
74DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90043779
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89220654
76ERG_21242973_ChIP-ChIP_JURKAT_Human0.87982095
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83451589
78* KLF5_25053715_ChIP-Seq_YYC3_Human0.83000175
79CDX2_22108803_ChIP-Seq_LS180_Human0.81616362
80RUNX1_27514584_Chip-Seq_MCF-7_Human0.80047818
81* SOX2_21211035_ChIP-Seq_LN229_Human0.79969225
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.78113239
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77666786
84EGR1_19032775_ChIP-ChIP_M12_Human0.74528482
85ZNF263_19887448_ChIP-Seq_K562_Human0.74078548
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73929395
87PHF8_20622854_ChIP-Seq_HELA_Human0.73772309
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73203663
89RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73140670
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72766243
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71634436
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71263774
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71262414
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.70577423
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70571816
96* CTCF_20526341_ChIP-Seq_ESCs_Human0.70238725
97* HNFA_21074721_ChIP-Seq_CACO-2_Human0.69093354
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69066647
99E2F1_20622854_ChIP-Seq_HELA_Human0.68760613
100CREB1_26743006_Chip-Seq_LNCaP_Human0.68557673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.89898852
2MP0002139_abnormal_hepatobiliary_system7.66463281
3MP0005085_abnormal_gallbladder_physiolo5.93116849
4MP0005365_abnormal_bile_salt5.57117455
5MP0001666_abnormal_nutrient_absorption5.36489764
6MP0008875_abnormal_xenobiotic_pharmacok3.38015588
7MP0003868_abnormal_feces_composition3.32540555
8MP0009840_abnormal_foam_cell3.07280083
9MP0003252_abnormal_bile_duct3.00790629
10MP0004019_abnormal_vitamin_homeostasis2.65943542
11MP0010329_abnormal_lipoprotein_level2.62001736
12MP0002138_abnormal_hepatobiliary_system2.59750384
13MP0003195_calcinosis2.37123877
14MP0005332_abnormal_amino_acid2.32675418
15MP0010234_abnormal_vibrissa_follicle2.20337597
16MP0003183_abnormal_peptide_metabolism2.07295157
17MP0003806_abnormal_nucleotide_metabolis2.07187054
18MP0010155_abnormal_intestine_physiology1.87138533
19MP0009379_abnormal_foot_pigmentation1.81785457
20MP0004264_abnormal_extraembryonic_tissu1.76181889
21MP0003191_abnormal_cellular_cholesterol1.71553131
22MP0002876_abnormal_thyroid_physiology1.68889073
23MP0002118_abnormal_lipid_homeostasis1.64550250
24MP0001664_abnormal_digestion1.58256320
25MP0001764_abnormal_homeostasis1.58131366
26MP0009643_abnormal_urine_homeostasis1.57581187
27MP0000609_abnormal_liver_physiology1.52747855
28MP0004147_increased_porphyrin_level1.45987856
29MP0005670_abnormal_white_adipose1.44292439
30MP0000490_abnormal_crypts_of1.30926433
31MP0005409_darkened_coat_color1.24698342
32MP0003879_abnormal_hair_cell1.19361976
33MP0003866_abnormal_defecation1.17631452
34MP0005451_abnormal_body_composition1.16118144
35MP0009697_abnormal_copulation1.15456589
36MP0000462_abnormal_digestive_system1.14156900
37MP0005636_abnormal_mineral_homeostasis1.11467934
38MP0001663_abnormal_digestive_system1.09277668
39MP0005319_abnormal_enzyme/_coenzyme1.07815824
40MP0005166_decreased_susceptibility_to1.05652185
41MP0005381_digestive/alimentary_phenotyp1.02343867
42MP0005584_abnormal_enzyme/coenzyme_acti1.01742724
43MP0004782_abnormal_surfactant_physiolog0.98889788
44MP0000477_abnormal_intestine_morphology0.95662133
45MP0002971_abnormal_brown_adipose0.91270548
46MP0005448_abnormal_energy_balance0.91259725
47MP0002136_abnormal_kidney_physiology0.89684688
48MP0009642_abnormal_blood_homeostasis0.82845532
49MP0005535_abnormal_body_temperature0.81774824
50MP0001765_abnormal_ion_homeostasis0.81242922
51MP0001873_stomach_inflammation0.80281317
52MP0000678_abnormal_parathyroid_gland0.79612042
53MP0008872_abnormal_physiological_respon0.79476558
54MP0008469_abnormal_protein_level0.79473739
55MP0009764_decreased_sensitivity_to0.78753165
56MP0004043_abnormal_pH_regulation0.76599805
57MP0000598_abnormal_liver_morphology0.74801752
58MP0000604_amyloidosis0.71994758
59MP0001756_abnormal_urination0.71967842
60MP0010352_gastrointestinal_tract_polyps0.71294427
61MP0003718_maternal_effect0.70660906
62MP0005058_abnormal_lysosome_morphology0.69132812
63MP0005083_abnormal_biliary_tract0.68866519
64MP0000538_abnormal_urinary_bladder0.68746038
65MP0009785_altered_susceptibility_to0.67908722
66MP0001845_abnormal_inflammatory_respons0.67903209
67MP0002078_abnormal_glucose_homeostasis0.62290205
68MP0005666_abnormal_adipose_tissue0.62043404
69MP0004858_abnormal_nervous_system0.61939236
70MP0002796_impaired_skin_barrier0.57568754
71MP0002098_abnormal_vibrissa_morphology0.56769920
72MP0000566_synostosis0.56228834
73MP0005334_abnormal_fat_pad0.56163975
74MP0005165_increased_susceptibility_to0.55639816
75MP0003638_abnormal_response/metabolism_0.55219584
76MP0005376_homeostasis/metabolism_phenot0.55154009
77MP0002822_catalepsy0.54726599
78MP0009763_increased_sensitivity_to0.53492026
79MP0008004_abnormal_stomach_pH0.53485412
80MP0005408_hypopigmentation0.52702703
81MP0000249_abnormal_blood_vessel0.52325759
82MP0003329_amyloid_beta_deposits0.50358097
83MP0003959_abnormal_lean_body0.48968242
84MP0005395_other_phenotype0.47810916
85MP0009115_abnormal_fat_cell0.47489448
86MP0002089_abnormal_postnatal_growth/wei0.46491436
87MP0003953_abnormal_hormone_level0.46300065
88MP0002249_abnormal_larynx_morphology0.44562927
89MP0001501_abnormal_sleep_pattern0.42051711
90MP0003436_decreased_susceptibility_to0.41719606
91MP0010368_abnormal_lymphatic_system0.41568617
92MP0000230_abnormal_systemic_arterial0.41121798
93MP0002132_abnormal_respiratory_system0.40641545
94MP0003300_gastrointestinal_ulcer0.40332991
95MP0001881_abnormal_mammary_gland0.38096063
96MP0000470_abnormal_stomach_morphology0.37652016
97MP0005501_abnormal_skin_physiology0.37599000
98MP0000467_abnormal_esophagus_morphology0.35806289
99MP0005025_abnormal_response_to0.35151754
100MP0005023_abnormal_wound_healing0.34743877

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.18578864
2Abnormality of glutamine family amino acid metabolism (HP:0010902)8.01175707
3Hypobetalipoproteinemia (HP:0003563)7.02453399
4Complement deficiency (HP:0004431)6.36840641
5Systemic lupus erythematosus (HP:0002725)5.99210907
6Deep venous thrombosis (HP:0002625)5.53336163
7Abnormality of complement system (HP:0005339)5.49232734
8Abnormality of aromatic amino acid family metabolism (HP:0004338)5.30286124
9Fat malabsorption (HP:0002630)5.28648778
10Hydroxyprolinuria (HP:0003080)4.99714501
11Abnormality of proline metabolism (HP:0010907)4.99714501
12Conjugated hyperbilirubinemia (HP:0002908)4.91967693
13Prolonged partial thromboplastin time (HP:0003645)4.73034072
14Malnutrition (HP:0004395)4.64410250
15Xanthomatosis (HP:0000991)4.53389868
16Glomerulonephritis (HP:0000099)4.22657534
17Steatorrhea (HP:0002570)4.22441815
18Intrahepatic cholestasis (HP:0001406)4.12503851
19Abnormality of pyrimidine metabolism (HP:0004353)3.94635925
20Hypolipoproteinemia (HP:0010981)3.86195765
21Hyperlipoproteinemia (HP:0010980)3.70855055
22Hyperammonemia (HP:0001987)3.60863947
23Hyperglycinuria (HP:0003108)3.58820834
24Abnormality of serine family amino acid metabolism (HP:0010894)3.54009930
25Abnormality of glycine metabolism (HP:0010895)3.54009930
26Hemorrhage of the eye (HP:0011885)3.34798233
27Nephritis (HP:0000123)3.33943608
28Abnormality of vitamin metabolism (HP:0100508)3.26077140
29Joint hemorrhage (HP:0005261)3.25182206
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.15764194
31Ileus (HP:0002595)3.14138870
32Alkalosis (HP:0001948)3.02921827
33Abnormality of nucleobase metabolism (HP:0010932)3.02865982
34Glycosuria (HP:0003076)3.01671723
35Abnormality of urine glucose concentration (HP:0011016)3.01671723
36Widely patent fontanelles and sutures (HP:0004492)2.99462800
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94979172
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.84137870
39Acanthocytosis (HP:0001927)2.69990810
40Proximal tubulopathy (HP:0000114)2.68281774
41Gout (HP:0001997)2.67135472
42Abnormality of vitamin B metabolism (HP:0004340)2.65043332
43Chronic diarrhea (HP:0002028)2.63978178
44Metabolic acidosis (HP:0001942)2.61038824
45Abnormality of purine metabolism (HP:0004352)2.60804758
46Recurrent gram-negative bacterial infections (HP:0005420)2.59923559
47Epidermoid cyst (HP:0200040)2.55950773
48Hyperuricemia (HP:0002149)2.54013725
49Increased purine levels (HP:0004368)2.54013725
50Confusion (HP:0001289)2.53811622
51Delayed CNS myelination (HP:0002188)2.53044755
52Vascular calcification (HP:0004934)2.51327281
53Rickets (HP:0002748)2.49485129
54Nephrolithiasis (HP:0000787)2.48403205
55Hyperphosphaturia (HP:0003109)2.46790366
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.45720188
57Hypophosphatemia (HP:0002148)2.44002629
58Abdominal distention (HP:0003270)2.39643434
59Hyperglycinemia (HP:0002154)2.38817371
60Hyperactive renin-angiotensin system (HP:0000841)2.35070904
61Abnormality of the common coagulation pathway (HP:0010990)2.34875124
62Nausea (HP:0002018)2.34286767
63Abnormal urine phosphate concentration (HP:0012599)2.34207802
64Cerebral palsy (HP:0100021)2.32363458
65Generalized aminoaciduria (HP:0002909)2.32078319
66Pigmentary retinal degeneration (HP:0001146)2.31356300
67Facial shape deformation (HP:0011334)2.28542930
68Potter facies (HP:0002009)2.28542930
69Pancreatitis (HP:0001733)2.27419241
70Cardiovascular calcification (HP:0011915)2.18843119
71Hypercholesterolemia (HP:0003124)2.17994172
72Wide cranial sutures (HP:0010537)2.16625107
73Hyperbilirubinemia (HP:0002904)2.15358871
74Irritability (HP:0000737)2.15210303
75Abnormality of the intrinsic pathway (HP:0010989)2.14449433
76Megaloblastic anemia (HP:0001889)2.12714062
77Thin bony cortex (HP:0002753)2.12213932
78Abnormality of serum amino acid levels (HP:0003112)2.11488789
79Metabolic alkalosis (HP:0200114)2.10437171
80Abnormal enzyme/coenzyme activity (HP:0012379)2.08632800
81Hypoalphalipoproteinemia (HP:0003233)2.07506917
82Focal segmental glomerulosclerosis (HP:0000097)2.07211509
83Dicarboxylic aciduria (HP:0003215)2.07014416
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07014416
85Abnormality of alkaline phosphatase activity (HP:0004379)2.06088989
86Abnormal tarsal ossification (HP:0008369)2.05308537
87Spontaneous abortion (HP:0005268)2.04301601
88Elevated alkaline phosphatase (HP:0003155)2.01931822
89Azoospermia (HP:0000027)1.94847678
90Decreased circulating renin level (HP:0003351)1.89783473
91Congenital sensorineural hearing impairment (HP:0008527)1.89380570
92Hypotension (HP:0002615)1.88061563
93Poikilocytosis (HP:0004447)1.87432181
94Glomerulosclerosis (HP:0000096)1.84709311
95Lethargy (HP:0001254)1.83843624
96Hepatocellular carcinoma (HP:0001402)1.82949329
97Skin nodule (HP:0200036)1.77417169
98Renal tubular acidosis (HP:0001947)1.76898159
99Osteomalacia (HP:0002749)1.75731362
100Hypophosphatemic rickets (HP:0004912)1.74013924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.68588620
2ACVR1B5.43479854
3MST1R5.32799747
4EPHA23.97887948
5RIPK13.78652054
6NEK13.47291440
7PRKG22.62761851
8FGFR42.42672977
9LMTK22.33516588
10MET1.97128463
11TRIB31.87469750
12STK391.86826681
13MAP3K101.82052200
14EPHA31.79703505
15PTK61.71320106
16PIK3CA1.68926386
17EPHB21.61165613
18TYK21.56610362
19PRPF4B1.44451523
20MAP3K21.42106350
21PDK21.38934801
22OXSR11.38653265
23SIK11.34803591
24EPHB11.34774238
25MAP2K21.20576209
26MAP3K121.12446411
27TESK21.09652630
28GRK61.06037984
29MAP3K11.02386642
30ERBB20.99902457
31MYLK0.98506032
32PDPK10.98388762
33MAP3K30.97996733
34MATK0.95695330
35TESK10.95142137
36PRKACG0.93599329
37TAOK10.92389997
38DDR20.92115703
39DYRK1B0.88990501
40TBK10.88975782
41MAPK110.87980499
42PRKAA20.86393992
43MAP3K110.84938449
44IRAK30.83710286
45FER0.82181445
46FGFR30.81951288
47ZAP700.80885957
48EPHA40.80885561
49MAP2K60.74581481
50ABL20.72691402
51MAP4K10.71595360
52BCKDK0.70077155
53NLK0.69990016
54MST40.67257974
55PKN20.64096147
56IRAK10.62004378
57STK240.58847560
58PTK20.58654683
59PIK3CG0.58607273
60PDK10.57959651
61PRKCZ0.57871760
62CDC42BPA0.54605135
63RET0.51957027
64JAK10.51890605
65PRKCA0.51003255
66SRC0.48556591
67KSR20.44512247
68PBK0.43454585
69JAK20.42728097
70PIM20.42707790
71WNK40.40946315
72AKT30.40191860
73IGF1R0.39509779
74CSF1R0.38470322
75CAMK2D0.38178115
76PAK40.35717314
77CAMK2G0.35449595
78CDK60.35157809
79GRK10.33841595
80NME10.33281376
81TNIK0.29846153
82PRKCI0.29368000
83SMG10.29245692
84MAP3K140.28163756
85PDGFRA0.27741641
86BMX0.27649727
87RPS6KA20.25870605
88RIPK40.25159252
89PRKCD0.24602833
90PRKACA0.24059563
91TAOK20.23202224
92FYN0.21142884
93IKBKE0.19625631
94ICK0.19224851
95EEF2K0.18114310
96INSRR0.17880504
97PRKAA10.17146118
98MAP3K50.15151514
99TAOK30.15109358
100MAP2K10.15008020

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.85403846
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.45484603
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30336357
4Fat digestion and absorption_Homo sapiens_hsa049753.29996006
5Retinol metabolism_Homo sapiens_hsa008303.04028478
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00397284
7Arginine biosynthesis_Homo sapiens_hsa002202.81314482
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.79581121
9Chemical carcinogenesis_Homo sapiens_hsa052042.72481580
10* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.58827888
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.50079679
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.47088205
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.38981900
14Histidine metabolism_Homo sapiens_hsa003402.37433867
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.34230052
16Vitamin digestion and absorption_Homo sapiens_hsa049772.26280682
17Fatty acid degradation_Homo sapiens_hsa000712.23486418
18Complement and coagulation cascades_Homo sapiens_hsa046102.20680996
19Starch and sucrose metabolism_Homo sapiens_hsa005002.19873013
20Phenylalanine metabolism_Homo sapiens_hsa003602.07765736
21Linoleic acid metabolism_Homo sapiens_hsa005912.04189238
22Renin-angiotensin system_Homo sapiens_hsa046141.92455866
23Bile secretion_Homo sapiens_hsa049761.87865042
24Tyrosine metabolism_Homo sapiens_hsa003501.75403861
25Tryptophan metabolism_Homo sapiens_hsa003801.73658682
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69595139
27PPAR signaling pathway_Homo sapiens_hsa033201.66601103
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66467463
29Protein digestion and absorption_Homo sapiens_hsa049741.55109081
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53878078
31Sulfur metabolism_Homo sapiens_hsa009201.45002742
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42532580
33Arachidonic acid metabolism_Homo sapiens_hsa005901.40285235
34Fructose and mannose metabolism_Homo sapiens_hsa000511.35608863
35Arginine and proline metabolism_Homo sapiens_hsa003301.31818193
36Butanoate metabolism_Homo sapiens_hsa006501.28671256
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23790355
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22927628
39Mineral absorption_Homo sapiens_hsa049781.19187492
40Glycerolipid metabolism_Homo sapiens_hsa005611.18527947
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.15178337
42Pancreatic secretion_Homo sapiens_hsa049721.10531765
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09659932
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03323509
45Peroxisome_Homo sapiens_hsa041461.02172861
46Staphylococcus aureus infection_Homo sapiens_hsa051500.98685621
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95778583
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94855967
49Galactose metabolism_Homo sapiens_hsa000520.92542728
50Biosynthesis of amino acids_Homo sapiens_hsa012300.91664533
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82449124
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79289262
53Pyruvate metabolism_Homo sapiens_hsa006200.76055963
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75525668
55Fatty acid metabolism_Homo sapiens_hsa012120.74895823
56beta-Alanine metabolism_Homo sapiens_hsa004100.73450461
57Carbon metabolism_Homo sapiens_hsa012000.72380837
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65884069
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.64283328
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64263705
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61430728
62Vitamin B6 metabolism_Homo sapiens_hsa007500.58693602
63Sulfur relay system_Homo sapiens_hsa041220.58610552
64Propanoate metabolism_Homo sapiens_hsa006400.57190992
65ABC transporters_Homo sapiens_hsa020100.56270250
66Glutathione metabolism_Homo sapiens_hsa004800.54375744
67Prion diseases_Homo sapiens_hsa050200.52357739
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50109921
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47733919
70Other glycan degradation_Homo sapiens_hsa005110.42939344
71Metabolic pathways_Homo sapiens_hsa011000.41060032
72Pentose phosphate pathway_Homo sapiens_hsa000300.38159738
73Ether lipid metabolism_Homo sapiens_hsa005650.35025937
74Insulin resistance_Homo sapiens_hsa049310.26830085
75Pertussis_Homo sapiens_hsa051330.24479114
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.23758761
77Folate biosynthesis_Homo sapiens_hsa007900.20495135
78Sphingolipid metabolism_Homo sapiens_hsa006000.19361227
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.16234350
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15045673
81Fatty acid biosynthesis_Homo sapiens_hsa000610.14554723
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13424926
83Asthma_Homo sapiens_hsa053100.10344593
84Fatty acid elongation_Homo sapiens_hsa000620.10267907
85Glucagon signaling pathway_Homo sapiens_hsa049220.09473379
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08855386
87Lysine degradation_Homo sapiens_hsa003100.07132413
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.04707696
89Nitrogen metabolism_Homo sapiens_hsa009100.03797247
90Hepatitis C_Homo sapiens_hsa051600.01979741
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00101383
92Tight junction_Homo sapiens_hsa04530-0.1078115
93Amoebiasis_Homo sapiens_hsa05146-0.1077701
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1035808
95Autoimmune thyroid disease_Homo sapiens_hsa05320-0.1013471
96Steroid biosynthesis_Homo sapiens_hsa00100-0.0912046
97Allograft rejection_Homo sapiens_hsa05330-0.0799014
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0558177
99AMPK signaling pathway_Homo sapiens_hsa04152-0.0271852
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0191137

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