ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	drug catabolic process (GO:0042737)	6.46321560
2	exogenous drug catabolic process (GO:0042738)	6.45788899
3	epoxygenase P450 pathway (GO:0019373)	5.66500976
4	omega-hydroxylase P450 pathway (GO:0097267)	4.90241629
5	oxidative demethylation (GO:0070989)	4.85516339
6	drug metabolic process (GO:0017144)	4.67840464
7	cellular ketone body metabolic process (GO:0046950)	4.38328038
8	indole-containing compound catabolic process (GO:0042436)	4.19483383
9	indolalkylamine catabolic process (GO:0046218)	4.19483383
10	tryptophan catabolic process (GO:0006569)	4.19483383
11	uronic acid metabolic process (GO:0006063)	4.12351270
12	glucuronate metabolic process (GO:0019585)	4.12351270
13	aromatic amino acid family catabolic process (GO:0009074)	4.09527796
14	S-adenosylmethionine metabolic process (GO:0046500)	4.09233073
15	glyoxylate metabolic process (GO:0046487)	4.09051194
16	cellular glucuronidation (GO:0052695)	4.08262295
17	arginine metabolic process (GO:0006525)	4.06351054
18	ketone body metabolic process (GO:1902224)	3.99849049
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.98327761
20	L-phenylalanine catabolic process (GO:0006559)	3.98327761
21	alkaloid metabolic process (GO:0009820)	3.97439410
22	phenylpropanoid metabolic process (GO:0009698)	3.91493645
23	regulation of triglyceride catabolic process (GO:0010896)	3.83568674
24	indolalkylamine metabolic process (GO:0006586)	3.67696095
25	bile acid biosynthetic process (GO:0006699)	3.62384304
26	cellular biogenic amine catabolic process (GO:0042402)	3.61510240
27	amine catabolic process (GO:0009310)	3.61510240
28	arginine catabolic process (GO:0006527)	3.60570802
29	regulation of glucokinase activity (GO:0033131)	3.54144811
30	regulation of hexokinase activity (GO:1903299)	3.54144811
31	bile acid metabolic process (GO:0008206)	3.51947669
32	flavonoid metabolic process (GO:0009812)	3.46300503
33	tryptophan metabolic process (GO:0006568)	3.44861227
34	bile acid and bile salt transport (GO:0015721)	3.43411144
35	amino-acid betaine metabolic process (GO:0006577)	3.39042271
36	serine family amino acid catabolic process (GO:0009071)	3.30151820
37	platelet dense granule organization (GO:0060155)	3.29494506
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.28645175
39	protein K11-linked deubiquitination (GO:0035871)	3.26607102
40	L-methionine salvage (GO:0071267)	3.20785438
41	L-methionine biosynthetic process (GO:0071265)	3.20785438
42	amino acid salvage (GO:0043102)	3.20785438
43	L-phenylalanine metabolic process (GO:0006558)	3.20510675
44	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.20510675
45	drug transmembrane transport (GO:0006855)	3.19424009
46	behavioral response to nicotine (GO:0035095)	3.17214990
47	coenzyme catabolic process (GO:0009109)	3.15088861
48	water-soluble vitamin biosynthetic process (GO:0042364)	3.13316445
49	kynurenine metabolic process (GO:0070189)	3.12118613
50	positive regulation of fatty acid transport (GO:2000193)	3.12042890
51	regulation of guanylate cyclase activity (GO:0031282)	3.11637633
52	vitamin biosynthetic process (GO:0009110)	3.05664999
53	ethanol oxidation (GO:0006069)	3.04543217
54	regulation of protein activation cascade (GO:2000257)	3.02578251
55	positive regulation of icosanoid secretion (GO:0032305)	3.01074948
56	intestinal absorption (GO:0050892)	2.98151800
57	fat-soluble vitamin biosynthetic process (GO:0042362)	2.98013554
58	nucleobase catabolic process (GO:0046113)	2.97910170
59	triglyceride homeostasis (GO:0070328)	2.97526493
60	acylglycerol homeostasis (GO:0055090)	2.97526493
61	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.95295566
62	high-density lipoprotein particle remodeling (GO:0034375)	2.92437603
63	L-fucose catabolic process (GO:0042355)	2.91751733
64	fucose catabolic process (GO:0019317)	2.91751733
65	L-fucose metabolic process (GO:0042354)	2.91751733
66	aromatic amino acid family metabolic process (GO:0009072)	2.91576185
67	complement activation, alternative pathway (GO:0006957)	2.90149422
68	drug transport (GO:0015893)	2.89593458
69	detection of light stimulus involved in visual perception (GO:0050908)	2.87593056
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.87593056
71	heme transport (GO:0015886)	2.86271825
72	regulation of complement activation (GO:0030449)	2.85199601
73	auditory receptor cell stereocilium organization (GO:0060088)	2.82359892
74	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.81756284
75	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.81756284
76	photoreceptor cell maintenance (GO:0045494)	2.81328865
77	organic cation transport (GO:0015695)	2.80218489
78	reverse cholesterol transport (GO:0043691)	2.79980327
79	dopamine transport (GO:0015872)	2.79581702
80	positive regulation of guanylate cyclase activity (GO:0031284)	2.79215213
81	alpha-amino acid catabolic process (GO:1901606)	2.76109333
82	aldehyde catabolic process (GO:0046185)	2.75943438
83	sulfation (GO:0051923)	2.74023922
84	regulation of fibrinolysis (GO:0051917)	2.73788545
85	epithelial cilium movement (GO:0003351)	2.73239549
86	intestinal cholesterol absorption (GO:0030299)	2.72645215
87	cysteine metabolic process (GO:0006534)	2.72631600
88	quinone biosynthetic process (GO:1901663)	2.72268637
89	xenobiotic metabolic process (GO:0006805)	2.71870437
90	glycine metabolic process (GO:0006544)	2.70547705
91	protein-cofactor linkage (GO:0018065)	2.66324112
92	urate metabolic process (GO:0046415)	2.66075861
93	benzene-containing compound metabolic process (GO:0042537)	2.66008936
94	respiratory chain complex IV assembly (GO:0008535)	2.65239052
95	pyrimidine nucleobase catabolic process (GO:0006208)	2.64880998
96	quinone metabolic process (GO:1901661)	2.62669122
97	plasma lipoprotein particle remodeling (GO:0034369)	2.60003427
98	protein-lipid complex remodeling (GO:0034368)	2.60003427
99	macromolecular complex remodeling (GO:0034367)	2.60003427
100	transepithelial transport (GO:0070633)	2.59817681

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.59993094
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24522122
3	VDR_22108803_ChIP-Seq_LS180_Human	2.91048330
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.83781352
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.83080825
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56098531
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45982180
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44193605
9	FUS_26573619_Chip-Seq_HEK293_Human	2.08154381
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04498606
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.02013405
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01999252
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00145413
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99670675
15	P300_19829295_ChIP-Seq_ESCs_Human	1.96388523
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.91695729
17	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.84201051
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.83600109
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78699721
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75958371
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71707889
22	EWS_26573619_Chip-Seq_HEK293_Human	1.71263364
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64905014
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61575461
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55323976
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.55042252
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55042252
28	AR_25329375_ChIP-Seq_VCAP_Human	1.53136606
29	TCF4_22108803_ChIP-Seq_LS180_Human	1.52815004
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52563745
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.51997389
32	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.51912535
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51832083
34	STAT3_23295773_ChIP-Seq_U87_Human	1.50811746
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49450073
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46721420
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46064357
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43859575
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.43614822
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42837323
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42254192
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41054573
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41054573
44	AR_20517297_ChIP-Seq_VCAP_Human	1.40023901
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39573391
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.39516400
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.39236664
48	TCF4_23295773_ChIP-Seq_U87_Human	1.39057685
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38230822
50	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.37678724
51	CDX2_22108803_ChIP-Seq_LS180_Human	1.36777854
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36437367
53	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.36034668
54	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.36034668
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33333646
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32419465
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31898178
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31888328
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31687281
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30273199
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29575290
62	NCOR_22424771_ChIP-Seq_293T_Human	1.28457958
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27361943
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25043595
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24465767
66	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.23082466
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21932094
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20809222
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20411311
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20264407
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18560875
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18560875
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17236104
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15361101
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15292758
76	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.15194726
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14040539
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12920899
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12918829
80	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.12806692
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11871770
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10446921
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09892220
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09787472
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08954506
86	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.08525134
87	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.07936831
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07190650
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.06918991
90	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06521184
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06205711
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05930131
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05516421
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.05229694
95	* PHF8_20622853_ChIP-Seq_HELA_Human	1.04278777
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.03741364
97	* ETV1_20927104_ChIP-Seq_GIST48_Human	1.03189626
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02352465
99	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01678967
100	EZH2_22144423_ChIP-Seq_EOC_Human	1.01315462

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.10039853
2	MP0005360_urolithiasis	4.90649107
3	MP0003195_calcinosis	4.30500507
4	MP0005085_abnormal_gallbladder_physiolo	4.20353110
5	MP0008875_abnormal_xenobiotic_pharmacok	4.07990158
6	MP0005365_abnormal_bile_salt	3.94527770
7	MP0002138_abnormal_hepatobiliary_system	3.01433684
8	MP0001666_abnormal_nutrient_absorption	2.93273642
9	MP0003252_abnormal_bile_duct	2.92721140
10	MP0002876_abnormal_thyroid_physiology	2.74887975
11	MP0004043_abnormal_pH_regulation	2.33835174
12	MP0004147_increased_porphyrin_level	2.25028796
13	MP0008872_abnormal_physiological_respon	2.21792641
14	MP0001764_abnormal_homeostasis	2.20977888
15	MP0010329_abnormal_lipoprotein_level	2.20259370
16	MP0005551_abnormal_eye_electrophysiolog	2.16261463
17	MP0005332_abnormal_amino_acid	2.06071959
18	MP0003868_abnormal_feces_composition	1.84625590
19	MP0004019_abnormal_vitamin_homeostasis	1.79273466
20	MP0005084_abnormal_gallbladder_morpholo	1.69494728
21	MP0003806_abnormal_nucleotide_metabolis	1.57517792
22	MP0008877_abnormal_DNA_methylation	1.54752514
23	MP0009697_abnormal_copulation	1.54314090
24	MP0002102_abnormal_ear_morphology	1.52811350
25	MP0001501_abnormal_sleep_pattern	1.49379741
26	MP0001968_abnormal_touch/_nociception	1.47070306
27	MP0000372_irregular_coat_pigmentation	1.45933172
28	MP0002928_abnormal_bile_duct	1.45731644
29	MP0003718_maternal_effect	1.44422599
30	MP0005645_abnormal_hypothalamus_physiol	1.43665368
31	MP0001986_abnormal_taste_sensitivity	1.43393910
32	MP0006072_abnormal_retinal_apoptosis	1.35272948
33	MP0010386_abnormal_urinary_bladder	1.33265918
34	MP0003011_delayed_dark_adaptation	1.32795631
35	MP0002736_abnormal_nociception_after	1.27961534
36	MP0002837_dystrophic_cardiac_calcinosis	1.23686188
37	MP0009643_abnormal_urine_homeostasis	1.23147019
38	MP0001984_abnormal_olfaction	1.23057900
39	MP0002118_abnormal_lipid_homeostasis	1.22647779
40	MP0002638_abnormal_pupillary_reflex	1.21387436
41	MP0004142_abnormal_muscle_tone	1.21022031
42	MP0005646_abnormal_pituitary_gland	1.20229284
43	MP0001486_abnormal_startle_reflex	1.18319595
44	MP0006276_abnormal_autonomic_nervous	1.17967458
45	MP0005670_abnormal_white_adipose	1.16716158
46	MP0004885_abnormal_endolymph	1.15562108
47	MP0000427_abnormal_hair_cycle	1.15346016
48	MP0005253_abnormal_eye_physiology	1.14901445
49	MP0009745_abnormal_behavioral_response	1.11041220
50	MP0005174_abnormal_tail_pigmentation	1.08878613
51	MP0005636_abnormal_mineral_homeostasis	1.08366049
52	MP0001485_abnormal_pinna_reflex	1.07989540
53	MP0000230_abnormal_systemic_arterial	0.99509430
54	MP0000538_abnormal_urinary_bladder	0.99239585
55	MP0003183_abnormal_peptide_metabolism	0.97125367
56	MP0002938_white_spotting	0.96643662
57	MP0001756_abnormal_urination	0.96367282
58	MP0002272_abnormal_nervous_system	0.96042901
59	MP0000569_abnormal_digit_pigmentation	0.96034328
60	MP0003646_muscle_fatigue	0.94688170
61	MP0003787_abnormal_imprinting	0.94046425
62	MP0009046_muscle_twitch	0.91456167
63	MP0002254_reproductive_system_inflammat	0.90205245
64	MP0005448_abnormal_energy_balance	0.86813772
65	MP0004924_abnormal_behavior	0.84625364
66	MP0005386_behavior/neurological_phenoty	0.84625364
67	MP0000609_abnormal_liver_physiology	0.81275826
68	MP0001502_abnormal_circadian_rhythm	0.79458650
69	MP0004742_abnormal_vestibular_system	0.79217666
70	MP0005395_other_phenotype	0.78767474
71	MP0002653_abnormal_ependyma_morphology	0.76959281
72	MP0005167_abnormal_blood-brain_barrier	0.76768199
73	MP0009840_abnormal_foam_cell	0.75618082
74	MP0005535_abnormal_body_temperature	0.72596121
75	MP0002557_abnormal_social/conspecific_i	0.72478577
76	MP0002572_abnormal_emotion/affect_behav	0.72123324
77	MP0003638_abnormal_response/metabolism_	0.71664168
78	MP0001529_abnormal_vocalization	0.71367411
79	MP0002735_abnormal_chemical_nociception	0.71232629
80	MP0005410_abnormal_fertilization	0.71102121
81	MP0009764_decreased_sensitivity_to	0.70527626
82	MP0004133_heterotaxia	0.69881379
83	MP0006036_abnormal_mitochondrial_physio	0.69776759
84	MP0002136_abnormal_kidney_physiology	0.69573620
85	MP0001970_abnormal_pain_threshold	0.69241598
86	MP0005377_hearing/vestibular/ear_phenot	0.68746976
87	MP0003878_abnormal_ear_physiology	0.68746976
88	MP0008058_abnormal_DNA_repair	0.65855801
89	MP0003186_abnormal_redox_activity	0.65748866
90	MP0002064_seizures	0.65526713
91	MP0005319_abnormal_enzyme/_coenzyme	0.64781182
92	MP0005195_abnormal_posterior_eye	0.64622634
93	MP0005075_abnormal_melanosome_morpholog	0.64208274
94	MP0002229_neurodegeneration	0.63099971
95	MP0001664_abnormal_digestion	0.62627692
96	MP0004215_abnormal_myocardial_fiber	0.62512781
97	MP0000631_abnormal_neuroendocrine_gland	0.62283854
98	MP0005376_homeostasis/metabolism_phenot	0.62139608
99	MP0001324_abnormal_eye_pigmentation	0.62028135
100	MP0009642_abnormal_blood_homeostasis	0.61932481

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.79254161
2	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.72671063
3	True hermaphroditism (HP:0010459)	3.61873010
4	Pancreatic fibrosis (HP:0100732)	3.43752613
5	Type II lissencephaly (HP:0007260)	3.36939635
6	Abnormality of midbrain morphology (HP:0002418)	3.34307757
7	Molar tooth sign on MRI (HP:0002419)	3.34307757
8	Congenital stationary night blindness (HP:0007642)	3.33263275
9	Hypobetalipoproteinemia (HP:0003563)	3.27907271
10	Hyperventilation (HP:0002883)	3.08783160
11	Abnormality of the renal cortex (HP:0011035)	3.05351777
12	Hyperglycinuria (HP:0003108)	3.01589716
13	Abnormality of serine family amino acid metabolism (HP:0010894)	3.00896795
14	Abnormality of glycine metabolism (HP:0010895)	3.00896795
15	Hyperglycinemia (HP:0002154)	2.99564571
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.96035674
17	Prolonged partial thromboplastin time (HP:0003645)	2.93907323
18	Medial flaring of the eyebrow (HP:0010747)	2.90379799
19	Chronic hepatic failure (HP:0100626)	2.80819816
20	Nephronophthisis (HP:0000090)	2.78246927
21	Congenital sensorineural hearing impairment (HP:0008527)	2.77469085
22	Abnormality of urine glucose concentration (HP:0011016)	2.75678345
23	Glycosuria (HP:0003076)	2.75678345
24	Bile duct proliferation (HP:0001408)	2.66263241
25	Abnormal biliary tract physiology (HP:0012439)	2.66263241
26	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.65037971
27	Hydroxyprolinuria (HP:0003080)	2.64602230
28	Abnormality of proline metabolism (HP:0010907)	2.64602230
29	Abnormality of vitamin B metabolism (HP:0004340)	2.54870121
30	Abnormality of the renal medulla (HP:0100957)	2.54607981
31	Delayed CNS myelination (HP:0002188)	2.52068828
32	Decreased circulating renin level (HP:0003351)	2.51969443
33	Conjugated hyperbilirubinemia (HP:0002908)	2.50508474
34	Hyperlipoproteinemia (HP:0010980)	2.48832318
35	Tubular atrophy (HP:0000092)	2.48462754
36	Complement deficiency (HP:0004431)	2.44479897
37	Renal cortical cysts (HP:0000803)	2.44243654
38	Cystic liver disease (HP:0006706)	2.42232776
39	Gait imbalance (HP:0002141)	2.42191655
40	Attenuation of retinal blood vessels (HP:0007843)	2.40481797
41	Polydipsia (HP:0001959)	2.40012549
42	Abnormal drinking behavior (HP:0030082)	2.40012549
43	Congenital primary aphakia (HP:0007707)	2.40008720
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.37011267
45	Abnormality of vitamin metabolism (HP:0100508)	2.32380796
46	Abolished electroretinogram (ERG) (HP:0000550)	2.32379442
47	Fair hair (HP:0002286)	2.28242938
48	Ketosis (HP:0001946)	2.26954302
49	Decreased central vision (HP:0007663)	2.24739319
50	Nephrogenic diabetes insipidus (HP:0009806)	2.24261533
51	Cerebellar dysplasia (HP:0007033)	2.18810512
52	Methylmalonic aciduria (HP:0012120)	2.11864078
53	Acute encephalopathy (HP:0006846)	2.11546068
54	Methylmalonic acidemia (HP:0002912)	2.11450750
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.11263250
56	Ketoacidosis (HP:0001993)	2.10627902
57	Metabolic acidosis (HP:0001942)	2.08955273
58	Lethargy (HP:0001254)	2.08363711
59	Intrahepatic cholestasis (HP:0001406)	2.06093672
60	Generalized aminoaciduria (HP:0002909)	2.04370573
61	Hepatic necrosis (HP:0002605)	2.04153366
62	Alkalosis (HP:0001948)	2.03807767
63	Abnormal urine output (HP:0012590)	2.03744436
64	Hypothermia (HP:0002045)	2.03413621
65	Congenital hepatic fibrosis (HP:0002612)	2.03207076
66	Abnormality of macular pigmentation (HP:0008002)	2.03156905
67	Polyuria (HP:0000103)	2.02637353
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.02515679
69	Epidermoid cyst (HP:0200040)	2.01025977
70	Abnormality of serum amino acid levels (HP:0003112)	2.00883647
71	Febrile seizures (HP:0002373)	1.99597943
72	Fat malabsorption (HP:0002630)	1.97306839
73	Abnormality of pyrimidine metabolism (HP:0004353)	1.97192111
74	Proximal tubulopathy (HP:0000114)	1.96321173
75	Male pseudohermaphroditism (HP:0000037)	1.95584108
76	Increased CSF lactate (HP:0002490)	1.93349415
77	Metabolic alkalosis (HP:0200114)	1.89952547
78	Hyperammonemia (HP:0001987)	1.89413231
79	Genital tract atresia (HP:0001827)	1.89243582
80	Sclerocornea (HP:0000647)	1.88221248
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85559646
82	Hepatocellular necrosis (HP:0001404)	1.85495692
83	Stomach cancer (HP:0012126)	1.85163617
84	Vaginal atresia (HP:0000148)	1.84990471
85	Xanthomatosis (HP:0000991)	1.84616565
86	Lissencephaly (HP:0001339)	1.84262596
87	Furrowed tongue (HP:0000221)	1.84188042
88	Abnormality of renin-angiotensin system (HP:0000847)	1.83826887
89	Hypomagnesemia (HP:0002917)	1.83192499
90	Hyperphosphaturia (HP:0003109)	1.82540468
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.82473296
92	Poor coordination (HP:0002370)	1.81135154
93	Cerebral edema (HP:0002181)	1.79732949
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.78402965
95	Mitochondrial inheritance (HP:0001427)	1.77278044
96	Abnormality of renal excretion (HP:0011036)	1.76814973
97	Chorioretinal atrophy (HP:0000533)	1.76415996
98	Keratoconus (HP:0000563)	1.76258638
99	Increased corneal curvature (HP:0100692)	1.76258638
100	Absent speech (HP:0001344)	1.75202821

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.96650867
2	WNK3	3.52152762
3	PINK1	3.40143405
4	ACVR1B	2.90347122
5	ADRBK2	2.79016409
6	TAOK3	2.50129232
7	GRK1	2.40406572
8	BMPR1B	2.34571045
9	MAP4K2	2.27132530
10	ZAK	2.23648299
11	NUAK1	2.16455149
12	CASK	2.15230485
13	INSRR	2.04775346
14	WNK4	2.00669913
15	STK39	2.00557902
16	OXSR1	1.96578135
17	MAPK13	1.92117597
18	DAPK2	1.78367454
19	MAP3K4	1.72568961
20	BRSK2	1.67832470
21	TRIM28	1.67503219
22	EIF2AK3	1.55864852
23	AKT3	1.41011305
24	MKNK2	1.27643457
25	TNIK	1.22696216
26	PDK2	1.20812679
27	MST4	1.15916552
28	MUSK	1.13942169
29	ADRBK1	1.11100483
30	PAK3	1.08551365
31	PRKCE	1.03049256
32	TLK1	1.02778860
33	DYRK2	1.01570073
34	EPHA3	0.97216684
35	CAMKK2	0.96717982
36	BCR	0.96506723
37	MAP2K7	0.90215479
38	PRKCG	0.89496779
39	FGFR2	0.86811193
40	MAPKAPK3	0.86456630
41	PIK3CA	0.82795401
42	TIE1	0.82452064
43	ERBB3	0.80969473
44	WEE1	0.78458318
45	NTRK3	0.77507639
46	MAP2K6	0.75038899
47	PLK2	0.74862284
48	PTK2B	0.73515928
49	EPHA4	0.73222502
50	TXK	0.71428419
51	CCNB1	0.68116875
52	CSNK1G1	0.67508275
53	STK38L	0.65009478
54	VRK1	0.64546646
55	MARK1	0.64438365
56	IRAK1	0.63785033
57	PLK4	0.62938477
58	FER	0.62096832
59	MKNK1	0.59395128
60	TNK2	0.59090560
61	CSNK1A1	0.58496707
62	CSNK1G2	0.58161158
63	NME1	0.57705132
64	PRKCQ	0.56894236
65	PKN1	0.56286503
66	CSNK1G3	0.55738927
67	GRK7	0.55442422
68	MAPK15	0.54995402
69	PRKG2	0.54695783
70	PRKACA	0.54584815
71	STK3	0.52656426
72	PRKCZ	0.51389142
73	IKBKB	0.49493839
74	PIK3CG	0.47390489
75	PRKCA	0.46534881
76	TGFBR1	0.45053881
77	CAMK2A	0.44180101
78	PRKAA2	0.44092881
79	CAMK1	0.44087864
80	PRKACG	0.43994562
81	CSNK1A1L	0.42090701
82	NEK2	0.41711863
83	PRKG1	0.41658551
84	MAP2K4	0.40673187
85	PRKCI	0.40614344
86	MAP3K12	0.39337183
87	EIF2AK2	0.37725523
88	TEC	0.37566476
89	BCKDK	0.37389192
90	PHKG1	0.37357146
91	PHKG2	0.37357146
92	FLT3	0.36475111
93	PNCK	0.35480654
94	PRKAA1	0.35326054
95	MAPKAPK5	0.35026883
96	ERBB2	0.33094353
97	MAP2K2	0.32221168
98	CSNK1D	0.31184905
99	DYRK1A	0.30687427
100	NLK	0.30382779

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.48379545
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.93094692
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.81214368
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.79464265
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.74972361
6	Retinol metabolism_Homo sapiens_hsa00830	2.59855421
7	Butanoate metabolism_Homo sapiens_hsa00650	2.56829845
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.49719549
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.44686016
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.39821378
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.34626390
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.16765661
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.16148047
14	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.12274302
15	Fat digestion and absorption_Homo sapiens_hsa04975	2.06414465
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.02331002
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.93218386
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84838665
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.83851603
20	Fatty acid degradation_Homo sapiens_hsa00071	1.76190168
21	Propanoate metabolism_Homo sapiens_hsa00640	1.73829606
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70979523
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.70194458
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.69822648
25	Complement and coagulation cascades_Homo sapiens_hsa04610	1.66166115
26	Peroxisome_Homo sapiens_hsa04146	1.61421950
27	Arginine biosynthesis_Homo sapiens_hsa00220	1.60532351
28	Histidine metabolism_Homo sapiens_hsa00340	1.60345174
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.57459801
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53547700
31	Sulfur metabolism_Homo sapiens_hsa00920	1.45641972
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.42736159
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42509295
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.31316832
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.29696476
36	Phototransduction_Homo sapiens_hsa04744	1.28507022
37	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.26202196
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.25762359
39	Bile secretion_Homo sapiens_hsa04976	1.24314348
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22419807
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.19918208
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.19872271
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14571514
44	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.14385252
45	ABC transporters_Homo sapiens_hsa02010	1.11890298
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.09923110
47	Arginine and proline metabolism_Homo sapiens_hsa00330	1.08461268
48	PPAR signaling pathway_Homo sapiens_hsa03320	1.03881212
49	Phenylalanine metabolism_Homo sapiens_hsa00360	1.02955554
50	Mineral absorption_Homo sapiens_hsa04978	0.99225381
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93284524
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.93030186
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.91498981
54	One carbon pool by folate_Homo sapiens_hsa00670	0.88639383
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.87519463
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.86943147
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86576030
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73741596
59	Metabolic pathways_Homo sapiens_hsa01100	0.73412305
60	Protein export_Homo sapiens_hsa03060	0.72389238
61	Renin-angiotensin system_Homo sapiens_hsa04614	0.71263712
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66743190
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.63801916
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.63668678
65	Fatty acid elongation_Homo sapiens_hsa00062	0.63401426
66	Glutathione metabolism_Homo sapiens_hsa00480	0.60190978
67	Regulation of autophagy_Homo sapiens_hsa04140	0.60096370
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59514584
69	Serotonergic synapse_Homo sapiens_hsa04726	0.58264690
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.57768584
71	Nicotine addiction_Homo sapiens_hsa05033	0.53927791
72	Homologous recombination_Homo sapiens_hsa03440	0.53901091
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49049432
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48105817
75	Parkinsons disease_Homo sapiens_hsa05012	0.47538406
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.46516983
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.45538866
78	Lysine degradation_Homo sapiens_hsa00310	0.44649697
79	Sulfur relay system_Homo sapiens_hsa04122	0.42635387
80	Circadian rhythm_Homo sapiens_hsa04710	0.40477527
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.39752391
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39560906
83	Basal transcription factors_Homo sapiens_hsa03022	0.39353698
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38233546
85	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36685897
86	Insulin secretion_Homo sapiens_hsa04911	0.36253282
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.35638076
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35345995
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.34984571
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.32835456
91	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.32784707
92	Taste transduction_Homo sapiens_hsa04742	0.31669557
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29983270
94	Olfactory transduction_Homo sapiens_hsa04740	0.29074456
95	Pancreatic secretion_Homo sapiens_hsa04972	0.28343269
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.26507072
97	RNA polymerase_Homo sapiens_hsa03020	0.23812462
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.23028696
99	Huntingtons disease_Homo sapiens_hsa05016	0.22639365
100	Asthma_Homo sapiens_hsa05310	0.20559895

AKR7L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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