AKT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.28217987
2COPI coating of Golgi vesicle (GO:0048205)3.82846292
3Golgi transport vesicle coating (GO:0048200)3.82846292
4positive regulation of histone deacetylation (GO:0031065)3.78489406
5cytoskeletal anchoring at plasma membrane (GO:0007016)3.71376553
6stress fiber assembly (GO:0043149)3.66468466
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62151818
8mannose metabolic process (GO:0006013)3.61188046
9apoptotic cell clearance (GO:0043277)3.56616723
10positive regulation of Cdc42 GTPase activity (GO:0043089)3.52154845
11regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.51896946
12protein heterotrimerization (GO:0070208)3.45482385
13cell adhesion mediated by integrin (GO:0033627)3.44041399
14endodermal cell differentiation (GO:0035987)3.39922633
15regulation of glucose import in response to insulin stimulus (GO:2001273)3.35897675
16adherens junction assembly (GO:0034333)3.35058573
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.31898880
18epithelial cell-cell adhesion (GO:0090136)3.31768570
19cell-substrate junction assembly (GO:0007044)3.27864100
20protein localization to endosome (GO:0036010)3.27222839
21planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26905641
22skin morphogenesis (GO:0043589)3.25909849
23peptidyl-lysine dimethylation (GO:0018027)3.25833211
24positive regulation of nuclease activity (GO:0032075)3.23410745
25regulation of extracellular matrix disassembly (GO:0010715)3.18729029
26cardiac myofibril assembly (GO:0055003)3.14066965
27activation of Rac GTPase activity (GO:0032863)3.12620747
28regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09281737
29cortical actin cytoskeleton organization (GO:0030866)3.07298871
30peptidyl-proline hydroxylation (GO:0019511)2.94779990
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94125262
32basement membrane organization (GO:0071711)2.93448188
33semaphorin-plexin signaling pathway (GO:0071526)2.92938476
34endothelial cell chemotaxis (GO:0035767)2.92907903
35axon extension involved in axon guidance (GO:0048846)2.91629189
36neuron projection extension involved in neuron projection guidance (GO:1902284)2.91629189
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90854270
38protein hydroxylation (GO:0018126)2.90539838
39pinocytosis (GO:0006907)2.90289722
40sarcomere organization (GO:0045214)2.90121786
41proline biosynthetic process (GO:0006561)2.89582024
42vascular endothelial growth factor signaling pathway (GO:0038084)2.89123473
43regulation of nuclease activity (GO:0032069)2.88539726
44regulation of tight junction assembly (GO:2000810)2.87903393
45intracellular estrogen receptor signaling pathway (GO:0030520)2.85631653
46collagen fibril organization (GO:0030199)2.85442020
47barbed-end actin filament capping (GO:0051016)2.84420615
48regulation of histone H3-K27 methylation (GO:0061085)2.84299961
49endoplasmic reticulum unfolded protein response (GO:0030968)2.84256847
50positive regulation of receptor recycling (GO:0001921)2.83246110
51vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82155029
52negative regulation of heart growth (GO:0061117)2.80867219
53negative regulation of cardiac muscle tissue growth (GO:0055022)2.80867219
54focal adhesion assembly (GO:0048041)2.80366500
55cell-substrate adherens junction assembly (GO:0007045)2.80366500
56receptor catabolic process (GO:0032801)2.80176226
57protein retention in ER lumen (GO:0006621)2.79845217
58germ cell migration (GO:0008354)2.78116898
59branching involved in mammary gland duct morphogenesis (GO:0060444)2.77065618
60glucocorticoid receptor signaling pathway (GO:0042921)2.76588257
61hippo signaling (GO:0035329)2.75842191
62regulation of early endosome to late endosome transport (GO:2000641)2.75609177
63regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.74069657
64desmosome organization (GO:0002934)2.72476815
65positive regulation of keratinocyte differentiation (GO:0045618)2.71609672
66embryonic process involved in female pregnancy (GO:0060136)2.71183880
67epithelial cell differentiation involved in prostate gland development (GO:0060742)2.71095966
68growth hormone receptor signaling pathway (GO:0060396)2.70174312
69morphogenesis of an endothelium (GO:0003159)2.69109793
70endothelial tube morphogenesis (GO:0061154)2.69109793
71modulation by symbiont of host cellular process (GO:0044068)2.68860209
72positive regulation of protein deacetylation (GO:0090312)2.67370044
73cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.67039568
74cellular response to unfolded protein (GO:0034620)2.66940486
75positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61271547
76ER-nucleus signaling pathway (GO:0006984)2.61026463
77negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58239670
78chondrocyte proliferation (GO:0035988)2.58059496
79pentose-phosphate shunt (GO:0006098)2.57773567
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57093974
81negative regulation of erythrocyte differentiation (GO:0045647)2.56707472
82* negative regulation of cell size (GO:0045792)2.54103452
83negative regulation of potassium ion transmembrane transport (GO:1901380)2.53805798
84response to laminar fluid shear stress (GO:0034616)2.53619656
85glucose 6-phosphate metabolic process (GO:0051156)2.53120130
86embryonic eye morphogenesis (GO:0048048)2.52749177
87hemidesmosome assembly (GO:0031581)2.52361909
88atrioventricular valve morphogenesis (GO:0003181)2.51895198
89negative regulation of viral release from host cell (GO:1902187)2.51609661
90ear development (GO:0043583)2.50783470
91modulation by virus of host morphology or physiology (GO:0019048)2.50185673
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49771670
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49771670
943-UTR-mediated mRNA stabilization (GO:0070935)2.48358324
954-hydroxyproline metabolic process (GO:0019471)2.48041989
96cell migration involved in sprouting angiogenesis (GO:0002042)2.47276580
97blood vessel endothelial cell migration (GO:0043534)2.46939714
98polarized epithelial cell differentiation (GO:0030859)2.46153662
99collagen metabolic process (GO:0032963)2.45574225
100regulation of hippo signaling (GO:0035330)2.45096552
101cortical cytoskeleton organization (GO:0030865)2.44927464
102glucose catabolic process (GO:0006007)2.44577609
103substrate-dependent cell migration (GO:0006929)2.43520276
104cell-cell junction maintenance (GO:0045217)2.42232148
105platelet aggregation (GO:0070527)2.42225845
106heterochromatin organization (GO:0070828)2.41479629
107negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.41339452
108modulation by virus of host process (GO:0019054)2.41212826
109retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40413445
110surfactant homeostasis (GO:0043129)2.40035687
111cellular response to topologically incorrect protein (GO:0035967)2.39800291
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39426499
113extracellular matrix disassembly (GO:0022617)2.39150864
114embryonic foregut morphogenesis (GO:0048617)2.38525843
115positive regulation of epithelial to mesenchymal transition (GO:0010718)2.38147474
116* positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37771891
117glial cell proliferation (GO:0014009)2.37402302
118regulation of extracellular matrix organization (GO:1903053)2.37324297
119cellular response to growth hormone stimulus (GO:0071378)2.37204287
120corticosteroid receptor signaling pathway (GO:0031958)2.36918298
121substrate adhesion-dependent cell spreading (GO:0034446)2.36405203
122regulation of translational termination (GO:0006449)2.35670769
123amyloid precursor protein catabolic process (GO:0042987)2.35159726
124collagen catabolic process (GO:0030574)2.34804452
125positive regulation of extracellular matrix organization (GO:1903055)2.34558294
126heart trabecula formation (GO:0060347)2.34152069
127cytoplasmic mRNA processing body assembly (GO:0033962)2.33328866
128protein targeting to plasma membrane (GO:0072661)2.33278027
129multicellular organismal macromolecule metabolic process (GO:0044259)2.33246820
130regulation of NFAT protein import into nucleus (GO:0051532)2.32965756
131apoptotic process involved in morphogenesis (GO:0060561)2.32742837
132positive regulation of p38MAPK cascade (GO:1900745)2.32690452
133mRNA stabilization (GO:0048255)2.32671674
134RNA stabilization (GO:0043489)2.32671674
135regulation of p38MAPK cascade (GO:1900744)2.32266494
136positive regulation of lamellipodium assembly (GO:0010592)2.31824955
137positive regulation of endothelial cell apoptotic process (GO:2000353)2.30202109
138regulation of translational fidelity (GO:0006450)2.29616510
139dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.29601882
140positive regulation of lamellipodium organization (GO:1902745)2.29453174
141regulation of defense response to virus by virus (GO:0050690)2.29124720
142regulation of endothelial cell chemotaxis (GO:2001026)2.28285502
143hypotonic response (GO:0006971)2.27336206
144positive regulation of protein dephosphorylation (GO:0035307)2.25483267
145regulation of ARF GTPase activity (GO:0032312)2.24686479
146actin filament bundle assembly (GO:0051017)2.24449224
147actin filament bundle organization (GO:0061572)2.24449224
148embryonic camera-type eye morphogenesis (GO:0048596)2.23522348
149activation of JUN kinase activity (GO:0007257)2.21774562
150membrane protein ectodomain proteolysis (GO:0006509)2.21103855
151NADPH regeneration (GO:0006740)2.20969635
152embryo implantation (GO:0007566)2.18920310
153Rho protein signal transduction (GO:0007266)2.18321450
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.18307028
155eye morphogenesis (GO:0048592)2.15945684
156regulation of cholesterol homeostasis (GO:2000188)2.14945072
157regulation of cholesterol biosynthetic process (GO:0045540)2.14207988
158regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.12230112
159response to water (GO:0009415)2.11894837
160regulation of lipid kinase activity (GO:0043550)2.10894666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.03807634
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.21918172
3MYC_22102868_ChIP-Seq_BL_Human3.07780004
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.01221864
5* EGR1_19374776_ChIP-ChIP_THP-1_Human2.79259806
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.68062440
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.65032148
8KDM2B_26808549_Chip-Seq_DND41_Human2.50177235
9VDR_21846776_ChIP-Seq_THP-1_Human2.44389060
10TCF7_22412390_ChIP-Seq_EML_Mouse2.36797209
11* CLOCK_20551151_ChIP-Seq_293T_Human2.33767472
12* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.30091879
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.23031154
14LXR_22292898_ChIP-Seq_THP-1_Human2.17863834
15RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.15951647
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04279885
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.03481857
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00011187
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99651911
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95879792
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95728416
22ZNF263_19887448_ChIP-Seq_K562_Human1.92408001
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91482758
24P300_27058665_Chip-Seq_ZR-75-30cells_Human1.90296246
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90218209
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.89743617
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87115312
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.84757628
29KDM2B_26808549_Chip-Seq_K562_Human1.76327536
30KDM2B_26808549_Chip-Seq_JURKAT_Human1.75948392
31* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75419132
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74241051
33* ATF3_27146783_Chip-Seq_COLON_Human1.74178064
34MAF_26560356_Chip-Seq_TH1_Human1.64621206
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64191072
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62203812
37VDR_24763502_ChIP-Seq_THP-1_Human1.61360596
38UTX_26944678_Chip-Seq_JUKART_Human1.61336688
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60849615
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58253799
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54188667
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53767401
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52633595
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.51196846
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50758965
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50345503
47* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49713506
48FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.47732008
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.44970765
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44158991
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42105152
52* TBX20_22080862_ChIP-Seq_HEART_Mouse1.40963761
53* TBX20_22328084_ChIP-Seq_HEART_Mouse1.40963761
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.39928131
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37023040
56SPI1_23127762_ChIP-Seq_K562_Human1.36742450
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36600464
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36403819
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35857769
60TP53_22127205_ChIP-Seq_IMR90_Human1.34487208
61NCOR1_26117541_ChIP-Seq_K562_Human1.32471825
62* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30473316
63* SMC4_20622854_ChIP-Seq_HELA_Human1.29873400
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29853283
65* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27871010
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27241785
67* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26805556
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26394174
69* CREB1_26743006_Chip-Seq_LNCaP_Human1.23471344
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23452176
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.23121406
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22811482
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22053037
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.21917747
75* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21213290
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20091932
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.17098842
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17029288
79* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16997182
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15911447
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13927670
82* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13655029
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13289095
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12134598
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11864157
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10852064
87GATA1_19941826_ChIP-Seq_K562_Human1.10505492
88* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10318167
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09815437
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09116300
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07884359
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07001357
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06818798
94SCL_19346495_ChIP-Seq_HPC-7_Human1.05250393
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05154793
96* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03990460
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03624285
98* RXR_22158963_ChIP-Seq_LIVER_Mouse1.03422209
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03137939
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03137939
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.02580891
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.02233234
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01709260
104* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01470041
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01128861
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01039899
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00154450
108P68_20966046_ChIP-Seq_HELA_Human0.99941593
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.99297461
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99187036
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98931479
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98753068
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.98673294
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98207371
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97598088
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96258780
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95862876
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94906308
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94765182
120* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94726399
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93245959
122BRD4_25478319_ChIP-Seq_HGPS_Human0.92583557
123EP300_21415370_ChIP-Seq_HL-1_Mouse0.91882982
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.91333266
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.90957072
126GATA6_25053715_ChIP-Seq_YYC3_Human0.90901101
127* MAF_26560356_Chip-Seq_TH2_Human0.90741657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.28540582
2* MP0003705_abnormal_hypodermis_morpholog3.48490398
3MP0003300_gastrointestinal_ulcer2.96644424
4MP0003566_abnormal_cell_adhesion2.74849137
5MP0005451_abnormal_body_composition2.69776395
6MP0010352_gastrointestinal_tract_polyps2.60855411
7MP0002877_abnormal_melanocyte_morpholog2.60705944
8MP0003279_aneurysm2.56005527
9MP0005409_darkened_coat_color2.50008156
10MP0003303_peritoneal_inflammation2.47074826
11MP0006054_spinal_hemorrhage2.45460924
12MP0005623_abnormal_meninges_morphology2.45355197
13MP0005275_abnormal_skin_tensile2.33272774
14MP0003191_abnormal_cellular_cholesterol2.33152988
15MP0001958_emphysema2.23764525
16MP0005076_abnormal_cell_differentiation2.23489046
17MP0004084_abnormal_cardiac_muscle2.13331301
18MP0004272_abnormal_basement_membrane2.11026471
19MP0009278_abnormal_bone_marrow2.07605130
20MP0010234_abnormal_vibrissa_follicle2.01742521
21MP0008260_abnormal_autophagy1.96771509
22MP0002796_impaired_skin_barrier1.83030350
23MP0003453_abnormal_keratinocyte_physiol1.82549573
24* MP0000733_abnormal_muscle_development1.80117497
25MP0000751_myopathy1.72833204
26MP0003091_abnormal_cell_migration1.71225851
27MP0005023_abnormal_wound_healing1.67646324
28MP0005503_abnormal_tendon_morphology1.65745883
29MP0005257_abnormal_intraocular_pressure1.64007889
30MP0004264_abnormal_extraembryonic_tissu1.62628594
31MP0001849_ear_inflammation1.59307190
32MP0004510_myositis1.51840557
33MP0004808_abnormal_hematopoietic_stem1.50736536
34* MP0004087_abnormal_muscle_fiber1.45043621
35MP0000750_abnormal_muscle_regeneration1.45003697
36MP0010368_abnormal_lymphatic_system1.44270953
37MP0004381_abnormal_hair_follicle1.44127720
38MP0002249_abnormal_larynx_morphology1.37759535
39MP0000678_abnormal_parathyroid_gland1.36387203
40MP0004858_abnormal_nervous_system1.36120293
41* MP0010630_abnormal_cardiac_muscle1.35645104
42MP0000767_abnormal_smooth_muscle1.33909380
43MP0005501_abnormal_skin_physiology1.33316825
44MP0000537_abnormal_urethra_morphology1.32423953
45MP0003283_abnormal_digestive_organ1.28823985
46MP0002837_dystrophic_cardiac_calcinosis1.28710212
47MP0004185_abnormal_adipocyte_glucose1.23083182
48MP0008961_abnormal_basal_metabolism1.22496642
49MP0003045_fibrosis1.21573632
50MP0002896_abnormal_bone_mineralization1.17777640
51MP0003329_amyloid_beta_deposits1.16496839
52MP0000569_abnormal_digit_pigmentation1.16377880
53MP0004130_abnormal_muscle_cell1.15601592
54MP0002089_abnormal_postnatal_growth/wei1.13638012
55MP0009384_cardiac_valve_regurgitation1.12472188
56MP0003115_abnormal_respiratory_system1.12454809
57MP0000003_abnormal_adipose_tissue1.10108762
58MP0010307_abnormal_tumor_latency1.09775402
59MP0009053_abnormal_anal_canal1.08812162
60MP0004782_abnormal_surfactant_physiolog1.07476651
61MP0002128_abnormal_blood_circulation1.07357655
62MP0005330_cardiomyopathy1.06987856
63MP0002925_abnormal_cardiovascular_devel1.06465076
64MP0004233_abnormal_muscle_weight1.05921827
65MP0000013_abnormal_adipose_tissue1.05253061
66MP0002060_abnormal_skin_morphology1.02797510
67MP0009780_abnormal_chondrocyte_physiolo1.02484918
68MP0000428_abnormal_craniofacial_morphol1.02231741
69MP0001544_abnormal_cardiovascular_syste1.01802305
70MP0005385_cardiovascular_system_phenoty1.01802305
71MP0002098_abnormal_vibrissa_morphology1.01075870
72MP0005058_abnormal_lysosome_morphology1.00408555
73MP0003828_pulmonary_edema0.99765857
74MP0001915_intracranial_hemorrhage0.99663439
75MP0000467_abnormal_esophagus_morphology0.99232949
76MP0001348_abnormal_lacrimal_gland0.99196392
77MP0006138_congestive_heart_failure0.98810346
78MP0003567_abnormal_fetal_cardiomyocyte0.98265508
79MP0001879_abnormal_lymphatic_vessel0.96504357
80MP0000759_abnormal_skeletal_muscle0.96443037
81MP0003385_abnormal_body_wall0.94855270
82MP0005375_adipose_tissue_phenotype0.94780501
83MP0004947_skin_inflammation0.94676087
84MP0002234_abnormal_pharynx_morphology0.94654499
85MP0001873_stomach_inflammation0.94094535
86MP0000747_muscle_weakness0.93998346
87* MP0000266_abnormal_heart_morphology0.91351143
88MP0001614_abnormal_blood_vessel0.91175403
89MP0005621_abnormal_cell_physiology0.90500653
90MP0004036_abnormal_muscle_relaxation0.90475234
91MP0008775_abnormal_heart_ventricle0.89301089
92MP0002972_abnormal_cardiac_muscle0.89251972
93MP0000858_altered_metastatic_potential0.89232075
94MP0005167_abnormal_blood-brain_barrier0.89048740
95MP0005508_abnormal_skeleton_morphology0.88551741
96* MP0004197_abnormal_fetal_growth/weight/0.88444223
97MP0001545_abnormal_hematopoietic_system0.88077019
98MP0005397_hematopoietic_system_phenotyp0.88077019
99MP0000534_abnormal_ureter_morphology0.86536950
100MP0010030_abnormal_orbit_morphology0.85098132
101MP0003436_decreased_susceptibility_to0.84995906
102* MP0001216_abnormal_epidermal_layer0.84269340
103MP0003448_altered_tumor_morphology0.84042989
104MP0000462_abnormal_digestive_system0.83879314
105* MP0009931_abnormal_skin_appearance0.83851182
106MP0002998_abnormal_bone_remodeling0.83029983
107MP0003123_paternal_imprinting0.82825115
108MP0001533_abnormal_skeleton_physiology0.82555429
109MP0003172_abnormal_lysosome_physiology0.82504250
110MP0009840_abnormal_foam_cell0.82380344
111MP0002933_joint_inflammation0.82302936
112MP0000627_abnormal_mammary_gland0.80989906
113MP0003763_abnormal_thymus_physiology0.80648427
114MP0002269_muscular_atrophy0.80499699
115MP0003183_abnormal_peptide_metabolism0.79513251
116MP0005666_abnormal_adipose_tissue0.79401983
117MP0003221_abnormal_cardiomyocyte_apopto0.78197480
118MP0000490_abnormal_crypts_of0.76031255
119MP0000685_abnormal_immune_system0.75637247
120MP0003942_abnormal_urinary_system0.75197994
121MP0002106_abnormal_muscle_physiology0.74945228
122* MP0002086_abnormal_extraembryonic_tissu0.74632856
123MP0002396_abnormal_hematopoietic_system0.74396071
124MP0000343_altered_response_to0.74236462
125MP0005464_abnormal_platelet_physiology0.74112523
126MP0005390_skeleton_phenotype0.73678353
127MP0001243_abnormal_dermal_layer0.72142547
128MP0002166_altered_tumor_susceptibility0.69416388
129MP0002108_abnormal_muscle_morphology0.69125099
130MP0001730_embryonic_growth_arrest0.69002715
131MP0000579_abnormal_nail_morphology0.68817730
132MP0010155_abnormal_intestine_physiology0.67391969
133MP0001881_abnormal_mammary_gland0.66565901
134MP0000477_abnormal_intestine_morphology0.63694278

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.20751283
2Premature rupture of membranes (HP:0001788)4.33067713
3Cerebral aneurysm (HP:0004944)4.21680349
4Shallow orbits (HP:0000586)3.97188149
5Ankle contracture (HP:0006466)3.52536071
6Hyperacusis (HP:0010780)3.31421848
7Bladder diverticulum (HP:0000015)3.18430394
8Broad face (HP:0000283)3.11594492
9Dilatation of the ascending aorta (HP:0005111)3.04812091
10Aortic aneurysm (HP:0004942)3.04394062
11Aortic dissection (HP:0002647)3.01722316
12Mitral valve prolapse (HP:0001634)2.97270890
13Peritonitis (HP:0002586)2.92842989
14Increased connective tissue (HP:0009025)2.89567692
15Broad metatarsal (HP:0001783)2.86951819
16Cervical subluxation (HP:0003308)2.84237591
17Flat acetabular roof (HP:0003180)2.77349236
18Atrophic scars (HP:0001075)2.76827680
19Subacute progressive viral hepatitis (HP:0006572)2.72937489
20Aneurysm (HP:0002617)2.71081305
21Increased density of long bones (HP:0006392)2.70564951
22Genu recurvatum (HP:0002816)2.70043853
23Distal upper limb amyotrophy (HP:0007149)2.70025572
24Upper limb amyotrophy (HP:0009129)2.70025572
25Distal lower limb muscle weakness (HP:0009053)2.67614291
26Bowel diverticulosis (HP:0005222)2.63633361
27Fragile skin (HP:0001030)2.58528454
28Type 1 muscle fiber predominance (HP:0003803)2.53883721
29J-shaped sella turcica (HP:0002680)2.52398080
30Obstructive sleep apnea (HP:0002870)2.50335392
31Difficulty climbing stairs (HP:0003551)2.44787401
32Long toe (HP:0010511)2.35136413
33Hand muscle atrophy (HP:0009130)2.33950190
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32694224
35Short 4th metacarpal (HP:0010044)2.32694224
36Asymmetric septal hypertrophy (HP:0001670)2.31496668
37Ulnar bowing (HP:0003031)2.31445713
38Scapular winging (HP:0003691)2.29072315
39Mildly elevated creatine phosphokinase (HP:0008180)2.23788255
40Renal duplication (HP:0000075)2.23369854
41Biconcave vertebral bodies (HP:0004586)2.22053930
42Wormian bones (HP:0002645)2.20793338
43Right ventricular cardiomyopathy (HP:0011663)2.20070367
44Wrist flexion contracture (HP:0001239)2.17521236
45Increased variability in muscle fiber diameter (HP:0003557)2.16995882
46Striae distensae (HP:0001065)2.15925607
47Elfin facies (HP:0004428)2.15312883
48Blue sclerae (HP:0000592)2.14132963
49Hemorrhage of the eye (HP:0011885)2.13829010
50Spinal rigidity (HP:0003306)2.12182201
51Short nail (HP:0001799)2.11429269
52Achilles tendon contracture (HP:0001771)2.10448369
53Radial bowing (HP:0002986)2.09765011
54Renovascular hypertension (HP:0100817)2.09281021
55Soft skin (HP:0000977)2.07714952
56Abnormality of skeletal muscle fiber size (HP:0012084)2.05917052
57Abnormality of the 4th metacarpal (HP:0010012)2.05472216
58Long palpebral fissure (HP:0000637)2.05329715
59Rectal prolapse (HP:0002035)2.00208144
60Hematochezia (HP:0002573)1.99299821
61Limb-girdle muscle atrophy (HP:0003797)1.98581650
62Disproportionate tall stature (HP:0001519)1.98506245
63Insomnia (HP:0100785)1.98488363
64Sudden death (HP:0001699)1.97874870
65Osteolytic defects of the phalanges of the hand (HP:0009771)1.97832001
66Osteolytic defects of the hand bones (HP:0009699)1.97832001
67Vascular tortuosity (HP:0004948)1.97255892
68Camptodactyly of toe (HP:0001836)1.96350247
69* Deviation of the hallux (HP:0010051)1.96171863
70Interstitial pulmonary disease (HP:0006530)1.94296558
71Abnormality of the distal phalanges of the toes (HP:0010182)1.93826125
72Mitral regurgitation (HP:0001653)1.93430524
73* Hallux valgus (HP:0001822)1.92516141
74Dysostosis multiplex (HP:0000943)1.92106564
75Bowing of the arm (HP:0006488)1.91525787
76Bowed forearm bones (HP:0003956)1.91525787
77Flat cornea (HP:0007720)1.91271819
78Hyperparathyroidism (HP:0000843)1.90462343
79Ventricular tachycardia (HP:0004756)1.90133445
80Abnormality of the thoracic spine (HP:0100711)1.89051922
81Distal lower limb amyotrophy (HP:0008944)1.88411142
82Vertebral compression fractures (HP:0002953)1.87821054
83Pointed chin (HP:0000307)1.86805833
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.85988688
85Abnormality of the Achilles tendon (HP:0005109)1.85114774
86Arterial tortuosity (HP:0005116)1.84431768
87Slender build (HP:0001533)1.84372703
88Hypercortisolism (HP:0001578)1.83970138
89Persistence of primary teeth (HP:0006335)1.83727659
90Abnormality of the peritoneum (HP:0002585)1.83407457
91Urinary glycosaminoglycan excretion (HP:0003541)1.83055739
92Mucopolysacchariduria (HP:0008155)1.83055739
93Stridor (HP:0010307)1.83011043
94Overriding aorta (HP:0002623)1.82313590
95Sparse lateral eyebrow (HP:0005338)1.81658327
96Patellar dislocation (HP:0002999)1.81332973
97Hyperextensible skin (HP:0000974)1.79971155
98Cerebral inclusion bodies (HP:0100314)1.79870120
99Back pain (HP:0003418)1.79207560
100Abnormality of the calcaneus (HP:0008364)1.79070515
101Abnormality of the acetabulum (HP:0003170)1.78534424
102Hyporeflexia of lower limbs (HP:0002600)1.77933034
103Difficulty running (HP:0009046)1.77824474
104Deformed sella turcica (HP:0002681)1.77562065
105Bicuspid aortic valve (HP:0001647)1.77241440
106Abnormal ossification of hand bones (HP:0005921)1.76920887
107Lower limb amyotrophy (HP:0007210)1.74666120
108Cutaneous melanoma (HP:0012056)1.74011142
109Ankyloglossia (HP:0010296)1.73494986
110Subaortic stenosis (HP:0001682)1.73191278
111Abnormality of the left ventricular outflow tract (HP:0011103)1.73191278
112Cupped ribs (HP:0000887)1.73159392
113Exercise-induced muscle cramps (HP:0003710)1.73023583
114Advanced eruption of teeth (HP:0006288)1.72854445
115Elbow flexion contracture (HP:0002987)1.72219863
116Muscle fiber splitting (HP:0003555)1.72179577
117Cellulitis (HP:0100658)1.71732275
118Generalized amyotrophy (HP:0003700)1.71300912
119Absent frontal sinuses (HP:0002688)1.71272579
120Overgrowth (HP:0001548)1.70679048
121Dislocated radial head (HP:0003083)1.70585961
122Frequent falls (HP:0002359)1.70095146
123Coxa vara (HP:0002812)1.68620659
124Abnormality of the radial head (HP:0003995)1.67315845
125Eczematoid dermatitis (HP:0000976)1.67143175
126Abnormality of polysaccharide metabolism (HP:0011012)1.66594250
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66594250
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66594250
129Abnormality of carpal bone ossification (HP:0006257)1.66408413
130Metaphyseal cupping (HP:0003021)1.66136039
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.64059903
132Abnormality of oral frenula (HP:0000190)1.63861801
133Thin ribs (HP:0000883)1.62980136
134Abnormality of dentin (HP:0010299)1.62030894
135Spinal cord lesions (HP:0100561)1.61926762
136Syringomyelia (HP:0003396)1.61926762
137Bundle branch block (HP:0011710)1.61509378
138Ectopia lentis (HP:0001083)1.60120283
139Bone pain (HP:0002653)1.59995717
140Joint laxity (HP:0001388)1.59553741
141Premature skin wrinkling (HP:0100678)1.59151695
142Abdominal distention (HP:0003270)1.58631284
143Esophageal varix (HP:0002040)1.58279504
144Arnold-Chiari malformation (HP:0002308)1.56980731
145Polygenic inheritance (HP:0010982)1.56708528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.14113735
2TTN3.74198573
3* TRIB33.44031296
4MAP3K103.35813073
5SMG13.21189127
6ERN12.97130404
7PRPF4B2.90108375
8RIPK12.74564539
9PDGFRA2.44805432
10IRAK32.32312443
11EPHA22.29644070
12BMX1.96425572
13DMPK1.82523342
14SIK11.80473095
15SCYL21.78868970
16* PTK61.75152398
17DDR21.73014095
18PAK41.66990014
19TAOK11.52300931
20LATS11.46653815
21LATS21.40299342
22PAK21.38815158
23ALK1.37802581
24LMTK21.36820939
25EPHB11.36049304
26NME21.35944319
27KSR21.35817825
28PRKD31.31647384
29PTK21.31211126
30MAP3K131.29795717
31* LRRK21.28303565
32PRKD21.20461009
33TESK11.19920227
34EPHB21.17901036
35MAP4K11.16640321
36MAP2K31.16321988
37STK101.15077244
38PDGFRB1.08439844
39MARK21.07707171
40NEK11.07635928
41TGFBR21.03217358
42TAOK21.02794820
43ICK1.00228758
44PRKCH0.98561486
45* MTOR0.98458208
46SIK20.98402334
47MAP3K60.98012448
48MAP3K70.96592809
49CDK60.95777908
50RPS6KA40.94606848
51CAMK1D0.93473067
52NEK20.91886004
53FLT30.91363729
54* PKN20.91185450
55RIPK40.88746979
56MAP3K80.87027530
57IRAK40.85398759
58TYK20.84836327
59FGFR40.84585834
60ZAP700.83521924
61RPS6KA20.81003013
62ARAF0.80119978
63PAK60.79263126
64LIMK10.79072493
65* PDPK10.78564815
66CAMK1G0.77825690
67IRAK20.76954833
68MAPKAPK30.75340975
69RPS6KB20.74429136
70STK30.73716879
71TGFBR10.73694687
72* RET0.72343399
73CDK40.70003855
74NEK90.69994012
75FER0.69796376
76TYRO30.69317329
77PAK30.69266514
78JAK30.68691591
79MAPK110.68656499
80MST1R0.68514926
81SIK30.68299157
82MAP3K140.68199575
83CDK120.67656729
84CDK70.67387238
85MAP2K10.67331197
86FGFR10.67274613
87TRPM70.65885490
88EPHA30.65093828
89TNK20.64584647
90FGFR30.63354254
91PTK2B0.63208518
92ROCK10.61324834
93HCK0.61139122
94CDC42BPA0.61070535
95JAK10.60097885
96* ILK0.59424627
97PRKG20.59005475
98MAP2K20.58981100
99MAP3K10.58573676
100MAP3K110.57382537
101RPS6KA60.57339531
102MAP3K30.57227741
103* PRKD10.54496257
104DYRK1B0.53871711
105MOS0.53645365
106CSK0.52908014
107JAK20.50356481
108MAP3K20.49431821
109DAPK30.49277397
110STK380.48782113
111TESK20.48592469
112MAPK120.47770984
113GRK60.47043981
114NTRK10.46797943
115NEK60.46271106
116ROCK20.46155519
117KDR0.45642115
118MARK30.45442462
119BLK0.44246181
120BTK0.43815230
121MET0.42792108
122HIPK20.42401792
123STK240.42271550
124RPS6KC10.41574334
125RPS6KL10.41574334
126CSF1R0.41482184
127SGK30.40858967
128CHUK0.40457308
129MAP3K90.40287251
130BRAF0.38511299
131RPS6KA10.38182517
132MELK0.37933201
133MYLK0.37702230

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.49143035
2Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.22424192
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15313318
4* Chronic myeloid leukemia_Homo sapiens_hsa052202.13260161
5* Focal adhesion_Homo sapiens_hsa045102.06297137
6ECM-receptor interaction_Homo sapiens_hsa045121.81107727
7* Proteoglycans in cancer_Homo sapiens_hsa052051.80752120
8Dilated cardiomyopathy_Homo sapiens_hsa054141.70111004
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66220061
10Amoebiasis_Homo sapiens_hsa051461.64466791
11Bladder cancer_Homo sapiens_hsa052191.63618456
12Viral myocarditis_Homo sapiens_hsa054161.63413614
13* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60824040
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.55564959
15Adherens junction_Homo sapiens_hsa045201.51010942
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50793228
17* Small cell lung cancer_Homo sapiens_hsa052221.44300306
18Prion diseases_Homo sapiens_hsa050201.43412488
19* Neurotrophin signaling pathway_Homo sapiens_hsa047221.41568854
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36354452
21* Glioma_Homo sapiens_hsa052141.34974146
22Pentose phosphate pathway_Homo sapiens_hsa000301.33104990
23* Pancreatic cancer_Homo sapiens_hsa052121.32977955
24* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32913519
25* Platelet activation_Homo sapiens_hsa046111.29180454
26* VEGF signaling pathway_Homo sapiens_hsa043701.27865970
27MicroRNAs in cancer_Homo sapiens_hsa052061.27831366
28Leishmaniasis_Homo sapiens_hsa051401.27770957
29* Non-small cell lung cancer_Homo sapiens_hsa052231.26111279
30* Central carbon metabolism in cancer_Homo sapiens_hsa052301.24137641
31Fructose and mannose metabolism_Homo sapiens_hsa000511.23725137
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22668858
33* Toxoplasmosis_Homo sapiens_hsa051451.22546200
34* Endometrial cancer_Homo sapiens_hsa052131.20635189
35* mTOR signaling pathway_Homo sapiens_hsa041501.19298826
36Shigellosis_Homo sapiens_hsa051311.17004678
37* Osteoclast differentiation_Homo sapiens_hsa043801.16050536
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15793459
39* Insulin resistance_Homo sapiens_hsa049311.14991429
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14271238
41* ErbB signaling pathway_Homo sapiens_hsa040121.14228909
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.09209580
43* Hepatitis C_Homo sapiens_hsa051601.06638727
44* Acute myeloid leukemia_Homo sapiens_hsa052211.05498406
45* B cell receptor signaling pathway_Homo sapiens_hsa046621.05418817
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04372814
47Notch signaling pathway_Homo sapiens_hsa043301.01984057
48* Estrogen signaling pathway_Homo sapiens_hsa049151.00941270
49* Renal cell carcinoma_Homo sapiens_hsa052111.00815162
50* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99202567
51* Insulin signaling pathway_Homo sapiens_hsa049100.98577230
52* Colorectal cancer_Homo sapiens_hsa052100.98514602
53Salmonella infection_Homo sapiens_hsa051320.98109389
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96763344
55Galactose metabolism_Homo sapiens_hsa000520.96367199
56* Choline metabolism in cancer_Homo sapiens_hsa052310.96346791
57* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96202690
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95991511
59* HIF-1 signaling pathway_Homo sapiens_hsa040660.95960994
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95837770
61Endocytosis_Homo sapiens_hsa041440.94655418
62Inositol phosphate metabolism_Homo sapiens_hsa005620.94385390
63Protein digestion and absorption_Homo sapiens_hsa049740.93316171
64Thyroid cancer_Homo sapiens_hsa052160.93137829
65Hippo signaling pathway_Homo sapiens_hsa043900.92879298
66* Prolactin signaling pathway_Homo sapiens_hsa049170.91665670
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90500312
68* HTLV-I infection_Homo sapiens_hsa051660.90452989
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90171625
70Type II diabetes mellitus_Homo sapiens_hsa049300.88265766
71* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85934203
72* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85701047
73* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85607413
74* Apoptosis_Homo sapiens_hsa042100.84852477
75* Rap1 signaling pathway_Homo sapiens_hsa040150.83206735
76Viral carcinogenesis_Homo sapiens_hsa052030.83057093
77Lysosome_Homo sapiens_hsa041420.83032500
78* Hepatitis B_Homo sapiens_hsa051610.81765917
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81696276
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80550006
81Lysine degradation_Homo sapiens_hsa003100.80506361
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.79533584
83Gap junction_Homo sapiens_hsa045400.78671574
84Vibrio cholerae infection_Homo sapiens_hsa051100.76239609
85* Sphingolipid signaling pathway_Homo sapiens_hsa040710.76006270
86* TNF signaling pathway_Homo sapiens_hsa046680.75429830
87* AMPK signaling pathway_Homo sapiens_hsa041520.73927079
88* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73251759
89* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73103311
90* Pathways in cancer_Homo sapiens_hsa052000.73027021
91* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72676571
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72597678
93* Adipocytokine signaling pathway_Homo sapiens_hsa049200.71476791
94Dorso-ventral axis formation_Homo sapiens_hsa043200.71308437
95* Influenza A_Homo sapiens_hsa051640.71228984
96* Tight junction_Homo sapiens_hsa045300.70544836
97GnRH signaling pathway_Homo sapiens_hsa049120.70491445
98N-Glycan biosynthesis_Homo sapiens_hsa005100.70452296
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70249498
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69664830
101* Phospholipase D signaling pathway_Homo sapiens_hsa040720.67075739
102* Tuberculosis_Homo sapiens_hsa051520.66707371
103Pertussis_Homo sapiens_hsa051330.66211986
104* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62845160
105* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62312474
106* Prostate cancer_Homo sapiens_hsa052150.61365017
107Biosynthesis of amino acids_Homo sapiens_hsa012300.61313155
108Melanogenesis_Homo sapiens_hsa049160.61134164
109* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61083441
110* Chemokine signaling pathway_Homo sapiens_hsa040620.61043594
111* T cell receptor signaling pathway_Homo sapiens_hsa046600.60988355
112Antigen processing and presentation_Homo sapiens_hsa046120.59538189
113Nitrogen metabolism_Homo sapiens_hsa009100.59306544
114Legionellosis_Homo sapiens_hsa051340.58845130
115TGF-beta signaling pathway_Homo sapiens_hsa043500.58442628
116* FoxO signaling pathway_Homo sapiens_hsa040680.58425584
117Malaria_Homo sapiens_hsa051440.57852567
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57240953
119Long-term potentiation_Homo sapiens_hsa047200.53948514
120Axon guidance_Homo sapiens_hsa043600.48394495
121* Measles_Homo sapiens_hsa051620.48370773

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