AKT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid transmembrane transport (GO:1902001)5.16324763
2valine metabolic process (GO:0006573)5.12601389
3carnitine shuttle (GO:0006853)5.10180850
4regulation of sequestering of triglyceride (GO:0010889)5.04967134
5alpha-linolenic acid metabolic process (GO:0036109)4.92395945
6low-density lipoprotein particle clearance (GO:0034383)4.82231921
7* positive regulation of fatty acid beta-oxidation (GO:0032000)4.60482691
8biotin metabolic process (GO:0006768)4.52184320
9fatty acid beta-oxidation (GO:0006635)4.49092375
102-oxoglutarate metabolic process (GO:0006103)4.47692181
11negative regulation of erythrocyte differentiation (GO:0045647)4.44954250
12lysine catabolic process (GO:0006554)4.44100963
13lysine metabolic process (GO:0006553)4.44100963
14* positive regulation of fatty acid oxidation (GO:0046321)4.35726201
15* regulation of fatty acid oxidation (GO:0046320)4.29667068
16* regulation of fatty acid beta-oxidation (GO:0031998)4.25410146
17tricarboxylic acid metabolic process (GO:0072350)4.14980140
18mannose metabolic process (GO:0006013)4.11778498
19carnitine transmembrane transport (GO:1902603)4.02020307
20fatty acid oxidation (GO:0019395)4.00722021
21focal adhesion assembly (GO:0048041)3.96924794
22cell-substrate adherens junction assembly (GO:0007045)3.96924794
23lipid oxidation (GO:0034440)3.96550208
24acetyl-CoA metabolic process (GO:0006084)3.92294774
25triglyceride catabolic process (GO:0019433)3.92177030
26sulfur amino acid catabolic process (GO:0000098)3.85351237
27fatty acid catabolic process (GO:0009062)3.84231870
28adherens junction assembly (GO:0034333)3.83722765
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.80691244
30regulation of cholesterol storage (GO:0010885)3.78385303
31neutral lipid catabolic process (GO:0046461)3.78252633
32acylglycerol catabolic process (GO:0046464)3.78252633
33amino-acid betaine transport (GO:0015838)3.77536019
34carnitine transport (GO:0015879)3.77536019
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.74595909
36tricarboxylic acid cycle (GO:0006099)3.67445156
37regulation of cholesterol homeostasis (GO:2000188)3.67437037
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.67363165
39regulation of triglyceride catabolic process (GO:0010896)3.66763179
40positive regulation of triglyceride metabolic process (GO:0090208)3.61819896
41positive regulation of triglyceride biosynthetic process (GO:0010867)3.61051485
42branched-chain amino acid metabolic process (GO:0009081)3.54363309
43positive regulation of histone deacetylation (GO:0031065)3.52456712
44carnitine metabolic process (GO:0009437)3.51817572
45amino-acid betaine metabolic process (GO:0006577)3.50880451
46regulation of triglyceride biosynthetic process (GO:0010866)3.49145272
47fatty acid homeostasis (GO:0055089)3.46932294
48plasma lipoprotein particle clearance (GO:0034381)3.45210465
49oxaloacetate metabolic process (GO:0006107)3.44277533
50apoptotic process involved in morphogenesis (GO:0060561)3.42925291
51aspartate family amino acid catabolic process (GO:0009068)3.38464270
52monocarboxylic acid catabolic process (GO:0072329)3.38054467
53branched-chain amino acid catabolic process (GO:0009083)3.36429762
54* positive regulation of lipid catabolic process (GO:0050996)3.35144887
55ethanol oxidation (GO:0006069)3.33691606
56regulation of NFAT protein import into nucleus (GO:0051532)3.32552608
57intracellular estrogen receptor signaling pathway (GO:0030520)3.32153450
58regulation of histone H3-K27 methylation (GO:0061085)3.30695102
59complement activation, alternative pathway (GO:0006957)3.29561350
60cysteine metabolic process (GO:0006534)3.24618351
61insulin-like growth factor receptor signaling pathway (GO:0048009)3.23994141
62regulation of chromatin binding (GO:0035561)3.22004509
63short-chain fatty acid metabolic process (GO:0046459)3.21744599
64L-phenylalanine metabolic process (GO:0006558)3.20907201
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.20907201
66regulation of triglyceride metabolic process (GO:0090207)3.18959390
67growth hormone receptor signaling pathway (GO:0060396)3.18798823
68white fat cell differentiation (GO:0050872)3.17683265
69thioester biosynthetic process (GO:0035384)3.15255117
70acyl-CoA biosynthetic process (GO:0071616)3.15255117
71* positive regulation of fatty acid metabolic process (GO:0045923)3.15243677
72positive regulation of lipid storage (GO:0010884)3.15146981
73activation of Rac GTPase activity (GO:0032863)3.14434109
74creatine metabolic process (GO:0006600)3.09816849
75negative regulation of myotube differentiation (GO:0010832)3.09706119
76cell-substrate junction assembly (GO:0007044)3.09455834
77NADH metabolic process (GO:0006734)3.08901216
78positive regulation of myotube differentiation (GO:0010831)3.08527255
79L-phenylalanine catabolic process (GO:0006559)3.05616255
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.05616255
814-hydroxyproline metabolic process (GO:0019471)3.05592830
82histone H3-K36 demethylation (GO:0070544)3.03795076
83thymic T cell selection (GO:0045061)3.02985921
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02638941
85brown fat cell differentiation (GO:0050873)3.02509315
86negative regulation of cell size (GO:0045792)3.02267262
873-UTR-mediated mRNA stabilization (GO:0070935)3.00877626
88cellular response to virus (GO:0098586)3.00615220
89cellular modified amino acid catabolic process (GO:0042219)2.99204008
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.98904629
91glyoxylate metabolic process (GO:0046487)2.98636375
92negative regulation of fatty acid biosynthetic process (GO:0045717)2.98306616
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98233139
94intracellular lipid transport (GO:0032365)2.97254373
95maternal placenta development (GO:0001893)2.95498674
96acylglycerol homeostasis (GO:0055090)2.95041060
97triglyceride homeostasis (GO:0070328)2.95041060
98modulation by symbiont of host cellular process (GO:0044068)2.94277809
99quaternary ammonium group transport (GO:0015697)2.90778586
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90066838
101triglyceride metabolic process (GO:0006641)2.89869166
102cellular response to growth hormone stimulus (GO:0071378)2.88365799
103regulation of cholesterol metabolic process (GO:0090181)2.87970761
104peptidyl-glutamic acid carboxylation (GO:0017187)2.86615568
105protein carboxylation (GO:0018214)2.86615568
106positive thymic T cell selection (GO:0045059)2.85871052
107apoptotic cell clearance (GO:0043277)2.84675856
108phospholipid homeostasis (GO:0055091)2.83599344
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.83174190
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82622405
111negative regulation of viral release from host cell (GO:1902187)2.82217574
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81876360
113succinate metabolic process (GO:0006105)2.80995653
114* regulation of fatty acid metabolic process (GO:0019217)2.80172989
115modulation by virus of host process (GO:0019054)2.79875882
116lipid particle organization (GO:0034389)2.79282825
117positive regulation of protein deacetylation (GO:0090312)2.79170366
118acylglycerol metabolic process (GO:0006639)2.77845277
119semaphorin-plexin signaling pathway (GO:0071526)2.77786060
120homocysteine metabolic process (GO:0050667)2.77275029
121actin-myosin filament sliding (GO:0033275)2.76468451
122muscle filament sliding (GO:0030049)2.76468451
123serine family amino acid catabolic process (GO:0009071)2.75249081
124regulation of ARF protein signal transduction (GO:0032012)2.75081002
125triglyceride biosynthetic process (GO:0019432)2.72788445
126response to laminar fluid shear stress (GO:0034616)2.71350121
127neutral lipid metabolic process (GO:0006638)2.70874174
128regulation of early endosome to late endosome transport (GO:2000641)2.70728217
129regulation of fatty acid biosynthetic process (GO:0042304)2.70510787
130activation of JUN kinase activity (GO:0007257)2.70353540
131positive regulation of CREB transcription factor activity (GO:0032793)2.69028225
132fatty-acyl-CoA biosynthetic process (GO:0046949)2.68965378
133regulation of skeletal muscle contraction (GO:0014819)2.68924427
134negative regulation of fibrinolysis (GO:0051918)2.68713792
135carboxylic acid catabolic process (GO:0046395)2.68607373
136organic acid catabolic process (GO:0016054)2.68607373
137positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67278948
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65682870
139embryonic process involved in female pregnancy (GO:0060136)2.64258979
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.59893620
141striated muscle atrophy (GO:0014891)2.59680683
142* regulation of glucose import in response to insulin stimulus (GO:2001273)2.59357445
143protein localization to endosome (GO:0036010)2.59249748
144regulation of necroptotic process (GO:0060544)2.58956817
145basement membrane organization (GO:0071711)2.57520592
146positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57134808
147protein targeting to plasma membrane (GO:0072661)2.56916107
148regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56596555
149endothelial cell chemotaxis (GO:0035767)2.56572691
150skeletal muscle adaptation (GO:0043501)2.56308644
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50851923
152cellular response to epidermal growth factor stimulus (GO:0071364)2.48468596
153RNA stabilization (GO:0043489)2.46860903
154mRNA stabilization (GO:0048255)2.46860903
155activation of MAPKKK activity (GO:0000185)2.46025221
156modulation by virus of host morphology or physiology (GO:0019048)2.45922196
157negative regulation of striated muscle cell differentiation (GO:0051154)2.45183713
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.41202517
159regulation of histone deacetylation (GO:0031063)2.40640233
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40248283
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.38980168
162epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38514702
163cell-cell junction maintenance (GO:0045217)2.38029300
164regulation of gamma-delta T cell differentiation (GO:0045586)2.37994294
165glucocorticoid receptor signaling pathway (GO:0042921)2.37540081
166signal complex assembly (GO:0007172)2.37397188
167regulation of ARF GTPase activity (GO:0032312)2.37088057
168embryonic eye morphogenesis (GO:0048048)2.35989176
169peptidyl-lysine dimethylation (GO:0018027)2.34629374
170stress fiber assembly (GO:0043149)2.34545000
171antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33476833
172histone H4 deacetylation (GO:0070933)2.33302228
173positive regulation of gene expression, epigenetic (GO:0045815)2.31414202
174epithelial cell-cell adhesion (GO:0090136)2.30728358
175regulation of nucleobase-containing compound transport (GO:0032239)2.30072975
176positive regulation of gamma-delta T cell activation (GO:0046645)2.29912160
177apoptotic process involved in development (GO:1902742)2.29752835
178proline biosynthetic process (GO:0006561)2.27347766
179negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25695491
180SMAD protein complex assembly (GO:0007183)2.24866984
181histone lysine demethylation (GO:0070076)2.24772297
182negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.23996792
183negative regulation of cell killing (GO:0031342)2.23996792
184retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23771689
185T cell selection (GO:0045058)2.23592784
186regulation of gamma-delta T cell activation (GO:0046643)2.23580893
187negative regulation of necroptotic process (GO:0060546)2.23504843
188positive regulation of extracellular matrix organization (GO:1903055)2.23118888
189negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23028179
190atrioventricular valve morphogenesis (GO:0003181)2.22228509
191osteoblast development (GO:0002076)2.21439096
192positive regulation of protein dephosphorylation (GO:0035307)2.18499043
193negative regulation of skeletal muscle tissue development (GO:0048642)2.16921836
194embryonic camera-type eye morphogenesis (GO:0048596)2.16543700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.53927579
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.73175264
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.34388400
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.10420198
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.84552788
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.58683286
7CLOCK_20551151_ChIP-Seq_293T_Human3.34419534
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80108279
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77962727
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54191520
11ZNF263_19887448_ChIP-Seq_K562_Human2.49455080
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43336485
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40959559
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.15733597
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12933141
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06318643
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01127710
18LXR_22292898_ChIP-Seq_THP-1_Human1.89629153
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86063247
20MYC_22102868_ChIP-Seq_BL_Human1.81528934
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77844874
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76790446
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.76040046
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.76040046
25KDM2B_26808549_Chip-Seq_DND41_Human1.75871503
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.73345123
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68699438
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66682971
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.62955434
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.59213941
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.57692430
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57013378
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56918643
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54004538
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53576181
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50409342
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.48560703
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48319338
39VDR_21846776_ChIP-Seq_THP-1_Human1.47364013
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.47356704
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44203601
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43207948
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41728211
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.39512641
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38988640
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38920202
47ATF3_27146783_Chip-Seq_COLON_Human1.34007382
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31870476
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31085925
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.28817822
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27553218
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.26394544
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26160913
54MAF_26560356_Chip-Seq_TH1_Human1.25704157
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23701349
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.22754505
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.22109798
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22037723
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21911517
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20594918
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18148029
62FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17684565
63KDM2B_26808549_Chip-Seq_K562_Human1.17348838
64* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17106741
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16644667
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16186629
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16088550
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15900892
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.14902220
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14632668
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14151822
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14039344
73TP53_22127205_ChIP-Seq_IMR90_Human1.13831394
74GATA1_19941826_ChIP-Seq_K562_Human1.12954745
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12804349
76GATA1_22025678_ChIP-Seq_K562_Human1.12729939
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.12426419
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12032652
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11014567
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11001382
81CTCF_27219007_Chip-Seq_Bcells_Human1.09535354
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08900689
83P68_20966046_ChIP-Seq_HELA_Human1.08414610
84CREB1_26743006_Chip-Seq_LNCaP_Human1.07922076
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07193129
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.07082696
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06813368
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05012728
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02153467
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02074810
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.01702087
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01495126
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01182759
94UTX_26944678_Chip-Seq_JUKART_Human1.00840696
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00632623
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00435080
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00133329
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99922600
99CTCF_21964334_Chip-Seq_Bcells_Human0.99279304
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98551500
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98285433
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97605071
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97357693
104NCOR1_26117541_ChIP-Seq_K562_Human0.97094476
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96513636
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95816206
107SCL_19346495_ChIP-Seq_HPC-7_Human0.95351724
108* BCL6_27268052_Chip-Seq_Bcells_Human0.95175246
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95082600
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93839465
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.93720663
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.93700167
113* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93330569
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93049428
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.92177810
116* BCOR_27268052_Chip-Seq_Bcells_Human0.90133389
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90064790
118SMC4_20622854_ChIP-Seq_HELA_Human0.89255063
119TP63_22573176_ChIP-Seq_HFKS_Human0.88274155
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88158724
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.88088054
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87632649
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84257544
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83871849
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83814396
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83336472
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82628557
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82446202
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.82375246
130MAF_26560356_Chip-Seq_TH2_Human0.82289400
131* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80841610
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.80555396
133VDR_24763502_ChIP-Seq_THP-1_Human0.80462366
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79221302
135* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78945677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.87960395
2MP0005670_abnormal_white_adipose3.84171766
3MP0002139_abnormal_hepatobiliary_system3.54729745
4MP0003705_abnormal_hypodermis_morpholog3.53807551
5MP0002837_dystrophic_cardiac_calcinosis3.28877482
6* MP0004130_abnormal_muscle_cell3.25299100
7* MP0005666_abnormal_adipose_tissue2.98244850
8MP0005365_abnormal_bile_salt2.98019760
9MP0005360_urolithiasis2.71793982
10MP0008438_abnormal_cutaneous_collagen2.64918351
11MP0010329_abnormal_lipoprotein_level2.57309234
12MP0003646_muscle_fatigue2.55719071
13MP0000751_myopathy2.53120226
14* MP0004185_abnormal_adipocyte_glucose2.44317080
15* MP0005375_adipose_tissue_phenotype2.25048268
16MP0009840_abnormal_foam_cell2.20027590
17MP0005085_abnormal_gallbladder_physiolo2.19071406
18MP0002249_abnormal_larynx_morphology2.13457371
19* MP0002971_abnormal_brown_adipose2.05817161
20MP0004858_abnormal_nervous_system2.04900909
21MP0003191_abnormal_cellular_cholesterol2.01040482
22MP0004087_abnormal_muscle_fiber2.00578064
23MP0003436_decreased_susceptibility_to1.88528716
24MP0000749_muscle_degeneration1.87121277
25MP0004084_abnormal_cardiac_muscle1.82792777
26MP0005275_abnormal_skin_tensile1.79762630
27* MP0002118_abnormal_lipid_homeostasis1.78582207
28MP0000013_abnormal_adipose_tissue1.78054361
29MP0000003_abnormal_adipose_tissue1.77501273
30MP0003763_abnormal_thymus_physiology1.77141834
31MP0001348_abnormal_lacrimal_gland1.74114202
32MP0005409_darkened_coat_color1.73704017
33MP0005330_cardiomyopathy1.73302515
34MP0009278_abnormal_bone_marrow1.73111968
35MP0003091_abnormal_cell_migration1.71778047
36MP0000750_abnormal_muscle_regeneration1.70247894
37MP0001873_stomach_inflammation1.69652521
38* MP0000609_abnormal_liver_physiology1.66790880
39MP0003252_abnormal_bile_duct1.65476964
40MP0001849_ear_inflammation1.64592751
41MP0000678_abnormal_parathyroid_gland1.62364001
42MP0003453_abnormal_keratinocyte_physiol1.60368734
43MP0002269_muscular_atrophy1.58669469
44MP0004036_abnormal_muscle_relaxation1.58266806
45MP0003806_abnormal_nucleotide_metabolis1.58259321
46MP0008961_abnormal_basal_metabolism1.55010549
47MP0000747_muscle_weakness1.54902780
48MP0009115_abnormal_fat_cell1.53838356
49MP0004947_skin_inflammation1.52429049
50MP0003566_abnormal_cell_adhesion1.52374909
51MP0008260_abnormal_autophagy1.51795421
52MP0005332_abnormal_amino_acid1.50533542
53MP0000759_abnormal_skeletal_muscle1.49150783
54MP0000681_abnormal_thyroid_gland1.44528005
55MP0010630_abnormal_cardiac_muscle1.41915962
56MP0005334_abnormal_fat_pad1.41585124
57MP0003300_gastrointestinal_ulcer1.41120800
58MP0000537_abnormal_urethra_morphology1.40741026
59MP0008875_abnormal_xenobiotic_pharmacok1.37264914
60MP0005319_abnormal_enzyme/_coenzyme1.33417242
61MP0002106_abnormal_muscle_physiology1.32577303
62MP0005083_abnormal_biliary_tract1.31690660
63MP0009333_abnormal_splenocyte_physiolog1.31483464
64MP0000685_abnormal_immune_system1.30942655
65MP0002009_preneoplasia1.29674882
66MP0001544_abnormal_cardiovascular_syste1.29010468
67MP0005385_cardiovascular_system_phenoty1.29010468
68MP0004381_abnormal_hair_follicle1.26707732
69MP0003279_aneurysm1.26221369
70MP0002089_abnormal_postnatal_growth/wei1.25633372
71MP0005620_abnormal_muscle_contractility1.25116179
72MP0004233_abnormal_muscle_weight1.24400001
73MP0003172_abnormal_lysosome_physiology1.24256516
74MP0000858_altered_metastatic_potential1.23689900
75MP0004215_abnormal_myocardial_fiber1.23659012
76MP0006138_congestive_heart_failure1.22909394
77* MP0002970_abnormal_white_adipose1.22029911
78MP0005503_abnormal_tendon_morphology1.21730162
79MP0000733_abnormal_muscle_development1.21306371
80MP0002396_abnormal_hematopoietic_system1.20701486
81MP0006036_abnormal_mitochondrial_physio1.14258424
82MP0008775_abnormal_heart_ventricle1.12508159
83MP0005076_abnormal_cell_differentiation1.12501063
84MP0002972_abnormal_cardiac_muscle1.09202644
85MP0005584_abnormal_enzyme/coenzyme_acti1.08924139
86MP0003221_abnormal_cardiomyocyte_apopto1.08268109
87MP0002909_abnormal_adrenal_gland1.06955981
88MP0001666_abnormal_nutrient_absorption1.06471692
89MP0005369_muscle_phenotype1.05445468
90* MP0002078_abnormal_glucose_homeostasis1.05169322
91MP0004808_abnormal_hematopoietic_stem1.02914690
92MP0003879_abnormal_hair_cell1.02099082
93MP0009384_cardiac_valve_regurgitation1.01455282
94MP0001661_extended_life_span0.97719623
95MP0009643_abnormal_urine_homeostasis0.96001548
96MP0000703_abnormal_thymus_morphology0.95214062
97MP0005535_abnormal_body_temperature0.94249996
98MP0004145_abnormal_muscle_electrophysio0.91204362
99MP0003828_pulmonary_edema0.89740190
100MP0001730_embryonic_growth_arrest0.88364515
101MP0002933_joint_inflammation0.87729511
102MP0009780_abnormal_chondrocyte_physiolo0.87556213
103MP0000343_altered_response_to0.87494552
104MP0003329_amyloid_beta_deposits0.86984167
105MP0002060_abnormal_skin_morphology0.86821116
106MP0005058_abnormal_lysosome_morphology0.84765576
107MP0002254_reproductive_system_inflammat0.84613956
108MP0002166_altered_tumor_susceptibility0.84057012
109MP0004272_abnormal_basement_membrane0.83453162
110MP0000598_abnormal_liver_morphology0.82923646
111MP0005501_abnormal_skin_physiology0.81994443
112MP0003959_abnormal_lean_body0.81929924
113MP0002877_abnormal_melanocyte_morpholog0.81486367
114MP0005621_abnormal_cell_physiology0.80443171
115MP0000767_abnormal_smooth_muscle0.80360855
116MP0002998_abnormal_bone_remodeling0.79753199
117MP0003303_peritoneal_inflammation0.79310555
118MP0009931_abnormal_skin_appearance0.78370389
119MP0005448_abnormal_energy_balance0.78169945
120MP0005023_abnormal_wound_healing0.77831326
121MP0005623_abnormal_meninges_morphology0.77164227
122MP0002796_impaired_skin_barrier0.76392113
123MP0003115_abnormal_respiratory_system0.75541135
124MP0002398_abnormal_bone_marrow0.75497649
125MP0010352_gastrointestinal_tract_polyps0.75369667
126MP0002108_abnormal_muscle_morphology0.74774299
127MP0001958_emphysema0.73918116
128MP0003186_abnormal_redox_activity0.73599187
129MP0003656_abnormal_erythrocyte_physiolo0.72723130
130MP0003942_abnormal_urinary_system0.71198756
131MP0001533_abnormal_skeleton_physiology0.69778759
132MP0009672_abnormal_birth_weight0.69587637
133MP0001800_abnormal_humoral_immune0.66997155
134MP0003045_fibrosis0.66293010
135MP0002128_abnormal_blood_circulation0.66292622
136MP0005387_immune_system_phenotype0.65371687
137MP0001790_abnormal_immune_system0.65371687
138MP0003195_calcinosis0.65058245
139MP0000266_abnormal_heart_morphology0.64197949
140MP0002925_abnormal_cardiovascular_devel0.63785345
141MP0001853_heart_inflammation0.63658146
142MP0000534_abnormal_ureter_morphology0.62930504
143MP0002332_abnormal_exercise_endurance0.62124428
144* MP0005452_abnormal_adipose_tissue0.60383251
145MP0004510_myositis0.59700626
146MP0003690_abnormal_glial_cell0.59655671
147MP0003137_abnormal_impulse_conducting0.59136810
148MP0002138_abnormal_hepatobiliary_system0.59038617

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.53821520
2Exercise-induced myalgia (HP:0003738)4.27368371
3Increased connective tissue (HP:0009025)3.95747190
4Difficulty running (HP:0009046)3.79843390
5Hyperacusis (HP:0010780)3.75940420
6Hypoglycemic coma (HP:0001325)3.75656819
7Type 1 muscle fiber predominance (HP:0003803)3.70541900
8Hyperglycinuria (HP:0003108)3.65713920
9Obstructive sleep apnea (HP:0002870)3.64034698
10Ketoacidosis (HP:0001993)3.58992474
11Ketosis (HP:0001946)3.58605714
12Xanthomatosis (HP:0000991)3.58029941
13Hypoalphalipoproteinemia (HP:0003233)3.53687490
14Hyporeflexia of lower limbs (HP:0002600)3.51874923
15Rhabdomyolysis (HP:0003201)3.44132967
16Hyperammonemia (HP:0001987)3.33827406
17Deep venous thrombosis (HP:0002625)3.33024631
18Abnormality of serine family amino acid metabolism (HP:0010894)3.29777861
19Abnormality of glycine metabolism (HP:0010895)3.29777861
20Muscle fiber splitting (HP:0003555)3.28976332
21Exercise-induced muscle cramps (HP:0003710)3.22336217
22Broad face (HP:0000283)3.20869355
23Abnormality of the fingertips (HP:0001211)3.06161976
24Distal lower limb amyotrophy (HP:0008944)3.04726510
25Abnormality of fatty-acid metabolism (HP:0004359)3.04577957
26Hyperlipoproteinemia (HP:0010980)2.95766705
27Sudden death (HP:0001699)2.87142201
28Complement deficiency (HP:0004431)2.81433722
29Dysmetric saccades (HP:0000641)2.75711277
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74197481
31Myocardial infarction (HP:0001658)2.73770043
32Asymmetric septal hypertrophy (HP:0001670)2.72922133
33Protrusio acetabuli (HP:0003179)2.72526593
34Increased variability in muscle fiber diameter (HP:0003557)2.71058466
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.67449559
36Hypolipoproteinemia (HP:0010981)2.67127107
37Ulnar bowing (HP:0003031)2.61536655
38Hypertriglyceridemia (HP:0002155)2.60085252
39Muscle fiber inclusion bodies (HP:0100299)2.59812178
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57127717
41Ventricular tachycardia (HP:0004756)2.56494673
42Hyperglycinemia (HP:0002154)2.56293170
43Cerebral aneurysm (HP:0004944)2.55814025
44Abnormality of skeletal muscle fiber size (HP:0012084)2.54200943
45Right ventricular cardiomyopathy (HP:0011663)2.53071223
46Difficulty climbing stairs (HP:0003551)2.52646402
47Round ear (HP:0100830)2.50488700
48Thin bony cortex (HP:0002753)2.50198198
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.49370626
50Atrioventricular block (HP:0001678)2.44921857
51Flat acetabular roof (HP:0003180)2.44199752
52Calf muscle hypertrophy (HP:0008981)2.41106414
53Ulnar deviation of the wrist (HP:0003049)2.36757742
54Dicarboxylic aciduria (HP:0003215)2.36234020
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36234020
56Dislocated radial head (HP:0003083)2.33358032
57Lipoatrophy (HP:0100578)2.33322799
58Mildly elevated creatine phosphokinase (HP:0008180)2.33042656
59Abnormality of the Achilles tendon (HP:0005109)2.31155987
60Polycythemia (HP:0001901)2.30392371
61Stridor (HP:0010307)2.29536926
62Oligomenorrhea (HP:0000876)2.29480052
63Distal lower limb muscle weakness (HP:0009053)2.27815417
64Vertebral compression fractures (HP:0002953)2.27711862
65Broad metatarsal (HP:0001783)2.27306453
66* Acanthosis nigricans (HP:0000956)2.23668518
67Muscle stiffness (HP:0003552)2.23252876
68Epidermoid cyst (HP:0200040)2.22988892
69Intrahepatic cholestasis (HP:0001406)2.22758413
70Abnormality of the radial head (HP:0003995)2.22482557
71Disproportionate tall stature (HP:0001519)2.22008350
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20885362
73Rectal prolapse (HP:0002035)2.20857890
74Segmental peripheral demyelination/remyelination (HP:0003481)2.20111540
75EMG: myopathic abnormalities (HP:0003458)2.18255446
76Biconcave vertebral bodies (HP:0004586)2.18079000
77Muscle hypertrophy of the lower extremities (HP:0008968)2.17714428
78Abnormality of complement system (HP:0005339)2.17573360
79Achilles tendon contracture (HP:0001771)2.16939068
80Colitis (HP:0002583)2.16572370
81Abnormality of the calf musculature (HP:0001430)2.16313475
82Hyperglycemia (HP:0003074)2.16157272
83Persistence of primary teeth (HP:0006335)2.15587226
84Myopathic facies (HP:0002058)2.15119374
85Germ cell neoplasia (HP:0100728)2.14954433
86Ankle contracture (HP:0006466)2.14240514
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13837812
88Abnormal cartilage morphology (HP:0002763)2.11651931
89Skin nodule (HP:0200036)2.11391141
90Mitral regurgitation (HP:0001653)2.11329499
91Premature rupture of membranes (HP:0001788)2.10404075
92Subaortic stenosis (HP:0001682)2.08901236
93Abnormality of the left ventricular outflow tract (HP:0011103)2.08901236
94Multiple enchondromatosis (HP:0005701)2.08842962
95Asymmetry of the thorax (HP:0001555)2.07876910
96Lower limb amyotrophy (HP:0007210)2.07752934
97Distal arthrogryposis (HP:0005684)2.07517873
98Nemaline bodies (HP:0003798)2.04356981
99Bronchomalacia (HP:0002780)2.03871515
100Sparse lateral eyebrow (HP:0005338)2.03650677
101Onion bulb formation (HP:0003383)1.99180922
102Abnormality of proline metabolism (HP:0010907)1.98105873
103Hydroxyprolinuria (HP:0003080)1.98105873
104Mitral valve prolapse (HP:0001634)1.97686578
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.97164668
106Insulin-resistant diabetes mellitus (HP:0000831)1.96477965
107Aneurysm (HP:0002617)1.96431056
108Abnormal atrioventricular conduction (HP:0005150)1.95955008
109Lymphangioma (HP:0100764)1.95885310
110Abnormality of the thoracic spine (HP:0100711)1.94997040
111Back pain (HP:0003418)1.94955545
112Facial diplegia (HP:0001349)1.94399767
113Spinal rigidity (HP:0003306)1.94370595
114Easy fatigability (HP:0003388)1.94184890
115Heart block (HP:0012722)1.93277759
116Cervical subluxation (HP:0003308)1.92670730
117Emphysema (HP:0002097)1.92243360
118Hyperinsulinemic hypoglycemia (HP:0000825)1.90670128
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90065138
120Abnormality of the common coagulation pathway (HP:0010990)1.90027113
121Conjunctival hamartoma (HP:0100780)1.87449575
122Bundle branch block (HP:0011710)1.87070464
123Syringomyelia (HP:0003396)1.85628145
124Spinal cord lesions (HP:0100561)1.85628145
125Dilated cardiomyopathy (HP:0001644)1.85302061
126Macroorchidism (HP:0000053)1.83865921
127Hypoplastic ischia (HP:0003175)1.83798162
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83302337
129Cellulitis (HP:0100658)1.81833124
130Turricephaly (HP:0000262)1.81752413
131Slender build (HP:0001533)1.81607963
132Gout (HP:0001997)1.81345332
133Scapular winging (HP:0003691)1.80955412
134Eczematoid dermatitis (HP:0000976)1.80827690
135Hypoglycemic seizures (HP:0002173)1.80744657
136Aortic aneurysm (HP:0004942)1.80487147
137Long palpebral fissure (HP:0000637)1.80005338
138Progressive muscle weakness (HP:0003323)1.78813376
139Abnormality of the calcaneus (HP:0008364)1.78540011
140Distal upper limb amyotrophy (HP:0007149)1.77675572
141Upper limb amyotrophy (HP:0009129)1.77675572
142Hemorrhage of the eye (HP:0011885)1.77656186
143Frequent falls (HP:0002359)1.77623407
144Shallow orbits (HP:0000586)1.77162337
145Hypercortisolism (HP:0001578)1.75415514
146Bladder diverticulum (HP:0000015)1.73015577
147Blue sclerae (HP:0000592)1.72814190
148Renovascular hypertension (HP:0100817)1.72127113
149Fragile skin (HP:0001030)1.71539609
150Advanced eruption of teeth (HP:0006288)1.70136449
151Patellar dislocation (HP:0002999)1.69934993
152Increased IgE level (HP:0003212)1.69481893
153Thin ribs (HP:0000883)1.67955806
154Long eyelashes (HP:0000527)1.67889372
155Insomnia (HP:0100785)1.66968695
156Bowel incontinence (HP:0002607)1.66156348
157Bulbar palsy (HP:0001283)1.64646403
158Precocious puberty (HP:0000826)1.63969331
159Deep palmar crease (HP:0006191)1.63386616
160Pointed chin (HP:0000307)1.62707986
161Genu recurvatum (HP:0002816)1.61793293
162Arnold-Chiari malformation (HP:0002308)1.61598679
163Abnormality of the humeroradial joint (HP:0100744)1.59616499
164Reticulocytosis (HP:0001923)1.59509905
165Metaphyseal cupping (HP:0003021)1.58977588
166Heterotopia (HP:0002282)1.58110037
167Gastrointestinal inflammation (HP:0004386)1.58095290
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57058021
169Short nail (HP:0001799)1.56438633
170Gastrointestinal stroma tumor (HP:0100723)1.56074595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* TRIB34.83919790
2PKN23.63075114
3SIK13.31365619
4PRPF4B3.28399478
5BCKDK3.27127200
6TTN3.14567051
7ERN13.14534602
8SMG13.09517076
9FGFR42.42374327
10IRAK32.34757774
11EEF2K2.08147514
12RIPK12.06918487
13CAMK1D1.99884690
14PDGFRA1.97144622
15MAP3K101.91520278
16PHKG11.86340660
17PHKG21.86340660
18PDK41.83078947
19PDK31.83078947
20PTK61.71182146
21LMTK21.68123119
22MAP2K31.64000014
23DMPK1.57420632
24EPHB11.46207644
25FLT31.45381191
26CAMK1G1.37559501
27MARK21.35745707
28LRRK21.33078961
29OBSCN1.32710631
30FGFR31.28900099
31EPHA31.26687746
32ICK1.24297103
33SIK21.23574899
34PRKD31.22368490
35MAP3K131.20452665
36MAP3K31.18135397
37TAOK11.17605935
38EPHA21.17284558
39DDR21.17154136
40LATS11.11688793
41MAP3K71.07922483
42IRAK41.06144788
43MAPK111.03778427
44CDK61.03266063
45TYRO31.03131014
46RIPK41.02356298
47FGFR20.99757525
48PRKAA20.98110290
49MAP2K20.94820880
50NEK90.93641421
51MTOR0.91974578
52PIK3CG0.91557073
53JAK30.90214229
54JAK10.89204370
55TAOK20.87767825
56CAMKK10.87011929
57RPS6KA20.84145618
58NEK10.83592101
59TNK20.83105297
60MAP4K10.79663439
61RET0.79543152
62PRKCH0.79214552
63JAK20.78945715
64PRKD10.78717312
65* PDPK10.78586542
66PINK10.78429011
67ZAP700.78180192
68MAPKAPK30.76510862
69PDK20.76359633
70IRAK20.76229224
71BMX0.75797423
72PDGFRB0.75739400
73MAPK120.74528408
74TGFBR20.73440718
75PRKD20.73031915
76MELK0.72638791
77RPS6KL10.72147267
78RPS6KC10.72147267
79PRKAA10.71410665
80RPS6KB20.70643001
81CDK40.69321476
82MAP3K10.69315410
83FGFR10.68410311
84CDK80.67931307
85TBK10.67118811
86MUSK0.64456448
87INSRR0.64443326
88DYRK1B0.63717717
89TYK20.63320856
90MAP2K10.61058745
91RPS6KA60.60608018
92BLK0.60597491
93CSK0.59923033
94MAP3K140.59683159
95PTK20.57381788
96MAP3K20.56844627
97MAP3K110.54454423
98CDK120.54331893
99LATS20.53469515
100CDK90.52282808
101STK100.51782240
102MET0.51237482
103SGK30.51223363
104PAK20.50293008
105CHUK0.49646917
106BTK0.48738521
107GSK3A0.48388996
108MAP3K60.48220576
109MST1R0.48176532
110NME20.47755112
111CDK70.46984439
112* PDK10.45449908
113MAP3K50.44030063
114GRK60.43368407
115KSR20.42828962
116TIE10.42201810
117STK380.42126612
118PAK40.41941186
119RPS6KA40.41343598
120BRD40.40427831
121AKT20.39319847
122FER0.38005376
123TRPM70.37398776
124CAMK40.37256155
125WNK10.36815098
126MAPK70.36793913
127PRKACG0.36378740
128RPS6KA10.35777778
129IRAK10.35756016
130HIPK20.35436363
131EPHB20.33832117
132MAP3K80.33605190
133ALK0.33336376
134STK240.32668915
135BRAF0.32640417
136ITK0.32631422
137NLK0.32517972
138CDC42BPA0.31533039
139STK30.31303863
140KDR0.30809864

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.74363717
2Fatty acid degradation_Homo sapiens_hsa000713.49229283
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.30202393
4Propanoate metabolism_Homo sapiens_hsa006403.29399158
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.21198878
6Fatty acid metabolism_Homo sapiens_hsa012123.09770512
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.00293236
8PPAR signaling pathway_Homo sapiens_hsa033202.89548490
9Fatty acid biosynthesis_Homo sapiens_hsa000612.64286040
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56598759
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55076209
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.20443932
13Arginine biosynthesis_Homo sapiens_hsa002202.03918878
14Carbon metabolism_Homo sapiens_hsa012002.02283485
15* Non-small cell lung cancer_Homo sapiens_hsa052231.98259703
16Other glycan degradation_Homo sapiens_hsa005111.93071044
17Tryptophan metabolism_Homo sapiens_hsa003801.86512008
18* B cell receptor signaling pathway_Homo sapiens_hsa046621.86243636
19Pyruvate metabolism_Homo sapiens_hsa006201.85079622
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73235588
21Butanoate metabolism_Homo sapiens_hsa006501.66729140
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60107612
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59595696
24* Adipocytokine signaling pathway_Homo sapiens_hsa049201.58461946
25* Pancreatic cancer_Homo sapiens_hsa052121.57256817
26* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56408745
27beta-Alanine metabolism_Homo sapiens_hsa004101.52889108
28Biosynthesis of amino acids_Homo sapiens_hsa012301.49560712
29* Neurotrophin signaling pathway_Homo sapiens_hsa047221.45940282
30Caffeine metabolism_Homo sapiens_hsa002321.43455056
31* Renal cell carcinoma_Homo sapiens_hsa052111.40354647
32* Insulin resistance_Homo sapiens_hsa049311.39249197
33Peroxisome_Homo sapiens_hsa041461.37925533
34Complement and coagulation cascades_Homo sapiens_hsa046101.37787333
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36839146
36Glycerolipid metabolism_Homo sapiens_hsa005611.33916912
37* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33067628
38Fat digestion and absorption_Homo sapiens_hsa049751.31699283
39Lysine degradation_Homo sapiens_hsa003101.31593876
40Thyroid cancer_Homo sapiens_hsa052161.31145781
41* ErbB signaling pathway_Homo sapiens_hsa040121.29915766
42* Endometrial cancer_Homo sapiens_hsa052131.28126744
43* Glioma_Homo sapiens_hsa052141.26656218
44* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25380577
45GnRH signaling pathway_Homo sapiens_hsa049121.24479037
46* AMPK signaling pathway_Homo sapiens_hsa041521.21971342
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20844251
48Starch and sucrose metabolism_Homo sapiens_hsa005001.18984249
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16901768
50* T cell receptor signaling pathway_Homo sapiens_hsa046601.15845362
51* Osteoclast differentiation_Homo sapiens_hsa043801.15362907
52* Choline metabolism in cancer_Homo sapiens_hsa052311.13850564
53* Phospholipase D signaling pathway_Homo sapiens_hsa040721.11548002
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10581967
55* Hepatitis C_Homo sapiens_hsa051601.09012399
56* Prostate cancer_Homo sapiens_hsa052151.08714160
57Inositol phosphate metabolism_Homo sapiens_hsa005621.07526540
58MicroRNAs in cancer_Homo sapiens_hsa052061.05651743
59Selenocompound metabolism_Homo sapiens_hsa004501.05102015
60Staphylococcus aureus infection_Homo sapiens_hsa051501.04681745
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04342562
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03702834
63* Hepatitis B_Homo sapiens_hsa051611.02379766
64* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02344354
65* Insulin signaling pathway_Homo sapiens_hsa049101.01822668
66* Prolactin signaling pathway_Homo sapiens_hsa049170.99853208
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98221391
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.97235156
69Phenylalanine metabolism_Homo sapiens_hsa003600.97198224
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94681941
71* FoxO signaling pathway_Homo sapiens_hsa040680.93652065
72Bile secretion_Homo sapiens_hsa049760.93575158
73* TNF signaling pathway_Homo sapiens_hsa046680.92961518
74* Glucagon signaling pathway_Homo sapiens_hsa049220.89754461
75Pentose phosphate pathway_Homo sapiens_hsa000300.89235968
76Viral carcinogenesis_Homo sapiens_hsa052030.87853843
77* Colorectal cancer_Homo sapiens_hsa052100.87072448
78* Estrogen signaling pathway_Homo sapiens_hsa049150.86610197
79* HTLV-I infection_Homo sapiens_hsa051660.86136138
80* Toxoplasmosis_Homo sapiens_hsa051450.84724859
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83073967
82Leishmaniasis_Homo sapiens_hsa051400.81571955
83Fatty acid elongation_Homo sapiens_hsa000620.81030910
84* Influenza A_Homo sapiens_hsa051640.80636776
85Dilated cardiomyopathy_Homo sapiens_hsa054140.79012435
86Sulfur relay system_Homo sapiens_hsa041220.75918692
87* MAPK signaling pathway_Homo sapiens_hsa040100.75254261
88* Apoptosis_Homo sapiens_hsa042100.73465179
89Long-term potentiation_Homo sapiens_hsa047200.72923669
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71146293
91Tyrosine metabolism_Homo sapiens_hsa003500.70515638
92* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69434543
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68567941
94* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67311756
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.66479786
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66074809
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65668644
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64055703
99ABC transporters_Homo sapiens_hsa020100.63994020
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63384537
101Thyroid hormone synthesis_Homo sapiens_hsa049180.62962085
102* Measles_Homo sapiens_hsa051620.62333792
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60935259
104Chemical carcinogenesis_Homo sapiens_hsa052040.60755209
105Herpes simplex infection_Homo sapiens_hsa051680.60196532
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58953709
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58667269
108Arginine and proline metabolism_Homo sapiens_hsa003300.57834077
109Endocytosis_Homo sapiens_hsa041440.57428720
110* Focal adhesion_Homo sapiens_hsa045100.57346784
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56503668
112* Sphingolipid signaling pathway_Homo sapiens_hsa040710.56458249
113Viral myocarditis_Homo sapiens_hsa054160.55098228
114* Platelet activation_Homo sapiens_hsa046110.54954803
115* Pathways in cancer_Homo sapiens_hsa052000.54230796
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.54183116
117Fructose and mannose metabolism_Homo sapiens_hsa000510.53391499
118* Central carbon metabolism in cancer_Homo sapiens_hsa052300.53294241
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53142436
120* Jak-STAT signaling pathway_Homo sapiens_hsa046300.48885738
121* Chemokine signaling pathway_Homo sapiens_hsa040620.48824283
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48639765
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.47759050
124* Epstein-Barr virus infection_Homo sapiens_hsa051690.47006877
125* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44454324
126Histidine metabolism_Homo sapiens_hsa003400.44029068
127Retinol metabolism_Homo sapiens_hsa008300.42083039
128ECM-receptor interaction_Homo sapiens_hsa045120.41516003
129Vitamin B6 metabolism_Homo sapiens_hsa007500.40178240
130* mTOR signaling pathway_Homo sapiens_hsa041500.39805904
131Galactose metabolism_Homo sapiens_hsa000520.39423969
132* Proteoglycans in cancer_Homo sapiens_hsa052050.39010035
133Type II diabetes mellitus_Homo sapiens_hsa049300.38626133
134* Chronic myeloid leukemia_Homo sapiens_hsa052200.36646588
135Amoebiasis_Homo sapiens_hsa051460.36091394
136Sulfur metabolism_Homo sapiens_hsa009200.35110178
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.35106386
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.32961398
139Bladder cancer_Homo sapiens_hsa052190.32496543
140* Acute myeloid leukemia_Homo sapiens_hsa052210.31968812
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.30540302
142Protein digestion and absorption_Homo sapiens_hsa049740.28289279
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27085322
144Adherens junction_Homo sapiens_hsa045200.26062587
145* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24447064
146Circadian rhythm_Homo sapiens_hsa047100.23727333
147* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22888528
148* Small cell lung cancer_Homo sapiens_hsa052220.21065191
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20873214
150Folate biosynthesis_Homo sapiens_hsa007900.18159140
151* HIF-1 signaling pathway_Homo sapiens_hsa040660.17770463
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.17495425
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.17484994
154Prion diseases_Homo sapiens_hsa050200.17400408
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17288819
156* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16531247
157* VEGF signaling pathway_Homo sapiens_hsa043700.16154252
158* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15608976
159Notch signaling pathway_Homo sapiens_hsa043300.15406160
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15353731

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