AKT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.76493183
2locomotory exploration behavior (GO:0035641)5.70601669
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45163372
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11965204
5presynaptic membrane assembly (GO:0097105)4.98732925
6layer formation in cerebral cortex (GO:0021819)4.95718118
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91293723
8presynaptic membrane organization (GO:0097090)4.62564040
9synaptic vesicle exocytosis (GO:0016079)4.56606140
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54187942
11glutamate secretion (GO:0014047)4.48446279
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.47830707
13vocalization behavior (GO:0071625)4.47700103
14regulation of synaptic vesicle exocytosis (GO:2000300)4.46363984
15exploration behavior (GO:0035640)4.41827589
16pyrimidine nucleobase catabolic process (GO:0006208)4.40860678
17dendritic spine morphogenesis (GO:0060997)4.35786212
18regulation of glutamate receptor signaling pathway (GO:1900449)4.30913025
19protein localization to synapse (GO:0035418)4.16257997
20regulation of synapse structural plasticity (GO:0051823)4.08295157
21dendrite morphogenesis (GO:0048813)3.93059833
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.84618396
23proline transport (GO:0015824)3.84238568
24regulation of synaptic vesicle transport (GO:1902803)3.84112126
25neuron cell-cell adhesion (GO:0007158)3.84037989
26regulation of neuronal synaptic plasticity (GO:0048168)3.83622940
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.73764977
28positive regulation of synapse maturation (GO:0090129)3.68227410
29neurotransmitter secretion (GO:0007269)3.58479376
30cell migration in hindbrain (GO:0021535)3.53118153
31nucleobase catabolic process (GO:0046113)3.53047714
32axonal fasciculation (GO:0007413)3.51322594
33neuron recognition (GO:0008038)3.43894765
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43795416
35innervation (GO:0060384)3.43546797
36synaptic transmission, glutamatergic (GO:0035249)3.42601880
37activation of protein kinase A activity (GO:0034199)3.40788593
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37575124
39central nervous system projection neuron axonogenesis (GO:0021952)3.36318507
40neurotransmitter-gated ion channel clustering (GO:0072578)3.35951022
41establishment of nucleus localization (GO:0040023)3.33711463
42long-term memory (GO:0007616)3.33076831
43glutamate receptor signaling pathway (GO:0007215)3.30678788
44regulation of ARF protein signal transduction (GO:0032012)3.30060296
45negative regulation of dendrite development (GO:2000171)3.27306283
46regulation of dendritic spine morphogenesis (GO:0061001)3.26381536
47sodium ion export (GO:0071436)3.25849782
48cellular potassium ion homeostasis (GO:0030007)3.25416630
49vesicle transport along microtubule (GO:0047496)3.23269688
50cerebellar Purkinje cell differentiation (GO:0021702)3.21012733
51neuromuscular process controlling balance (GO:0050885)3.20804588
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18775744
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18197988
54neuronal action potential propagation (GO:0019227)3.17393876
55cell communication by electrical coupling (GO:0010644)3.15887766
56neuron-neuron synaptic transmission (GO:0007270)3.13459440
57dendritic spine organization (GO:0097061)3.11432356
58positive regulation of membrane potential (GO:0045838)3.10174905
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07723035
60regulation of synaptic plasticity (GO:0048167)3.07274197
61clathrin coat assembly (GO:0048268)3.05412829
62regulation of postsynaptic membrane potential (GO:0060078)3.05236296
63organelle transport along microtubule (GO:0072384)3.04024275
64cerebellar granule cell differentiation (GO:0021707)3.01481149
65synaptic vesicle endocytosis (GO:0048488)3.01351385
66nerve growth factor signaling pathway (GO:0038180)3.00979135
67positive regulation of dendritic spine morphogenesis (GO:0061003)2.98185685
68startle response (GO:0001964)2.94874251
69gamma-aminobutyric acid transport (GO:0015812)2.93516975
70G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.90770157
71regulation of neurotransmitter secretion (GO:0046928)2.89943701
72positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86501008
73cerebral cortex radially oriented cell migration (GO:0021799)2.86046553
74response to auditory stimulus (GO:0010996)2.85993279
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85343478
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85217934
77membrane assembly (GO:0071709)2.85215095
78auditory behavior (GO:0031223)2.84863224
79membrane depolarization during action potential (GO:0086010)2.80948836
80spinal cord development (GO:0021510)2.80859781
81long-term synaptic potentiation (GO:0060291)2.80858633
82postsynaptic membrane organization (GO:0001941)2.80216581
83limb bud formation (GO:0060174)2.77946420
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77697177
85axon extension (GO:0048675)2.77344772
86positive regulation of synapse assembly (GO:0051965)2.77152496
87regulation of axon extension involved in axon guidance (GO:0048841)2.77044338
88regulation of axon guidance (GO:1902667)2.75403330
89prepulse inhibition (GO:0060134)2.75225840
90regulation of synapse assembly (GO:0051963)2.74422491
91behavioral defense response (GO:0002209)2.74140223
92behavioral fear response (GO:0001662)2.74140223
93neurotransmitter transport (GO:0006836)2.73126636
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.72561561
95transmission of nerve impulse (GO:0019226)2.69890577
96synapse assembly (GO:0007416)2.69774993
97regulation of vesicle fusion (GO:0031338)2.69288369
98regulation of dendritic spine development (GO:0060998)2.68569665
99central nervous system neuron axonogenesis (GO:0021955)2.68493118
100regulation of clathrin-mediated endocytosis (GO:2000369)2.66649708
101positive regulation of axon extension (GO:0045773)2.66046966
102cerebellum development (GO:0021549)2.65954968
103intraspecies interaction between organisms (GO:0051703)2.65202890
104social behavior (GO:0035176)2.65202890
105regulation of synapse maturation (GO:0090128)2.65108590
106membrane depolarization (GO:0051899)2.64478733
107axon cargo transport (GO:0008088)2.64272774
108neuronal ion channel clustering (GO:0045161)2.62758669
109chemosensory behavior (GO:0007635)2.62690541
110synapse organization (GO:0050808)2.61914380
111mechanosensory behavior (GO:0007638)2.61868828
112cerebellar Purkinje cell layer development (GO:0021680)2.60859574
113positive regulation of dendritic spine development (GO:0060999)2.60135533
114regulation of neurotransmitter transport (GO:0051588)2.59075993
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58872908
116adult walking behavior (GO:0007628)2.58697788
117neuromuscular process (GO:0050905)2.57862811
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56879021
119axonogenesis (GO:0007409)2.54899217
120negative regulation of neurotransmitter secretion (GO:0046929)2.54679667
121suckling behavior (GO:0001967)2.53836860
122retinal ganglion cell axon guidance (GO:0031290)2.53038806
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52987707
124cardiac ventricle formation (GO:0003211)2.52069815
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51687069
126heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.48885507
127negative regulation of neurotransmitter transport (GO:0051589)2.48136098
128negative regulation of dendrite morphogenesis (GO:0050774)2.46766990
129neuron projection extension (GO:1990138)2.46339653
130nucleus localization (GO:0051647)2.45106753
131neuromuscular synaptic transmission (GO:0007274)2.44591801
132urinary tract smooth muscle contraction (GO:0014848)2.43969094
133negative chemotaxis (GO:0050919)2.40056591
134regulation of synaptic transmission, GABAergic (GO:0032228)2.39708373
135regulation of synapse organization (GO:0050807)2.38996891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18499721
2GBX2_23144817_ChIP-Seq_PC3_Human3.07214281
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70613717
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68896483
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58643559
6DROSHA_22980978_ChIP-Seq_HELA_Human2.44394888
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41396612
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41396612
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39683393
10REST_21632747_ChIP-Seq_MESCs_Mouse2.38024030
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.36450734
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24058193
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22415297
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21668896
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20553482
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17309319
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17021010
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11366004
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07989029
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.98271957
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94578473
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92160970
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92110687
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.84044275
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.83435237
26AR_21572438_ChIP-Seq_LNCaP_Human1.80411688
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.78544789
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77720079
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77407938
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73193132
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68304839
32SMAD4_21799915_ChIP-Seq_A2780_Human1.61950818
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57675131
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57001265
35ZNF274_21170338_ChIP-Seq_K562_Hela1.55399101
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.55039198
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54689695
38FUS_26573619_Chip-Seq_HEK293_Human1.54670248
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53315101
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52035465
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48138397
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47725457
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46849947
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42009743
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37950574
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35989623
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35539006
48* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34951559
49* KDM2B_26808549_Chip-Seq_K562_Human1.34911734
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34637935
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33594165
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32330485
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.31691552
54STAT3_23295773_ChIP-Seq_U87_Human1.31261346
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30363881
56* AR_19668381_ChIP-Seq_PC3_Human1.30255865
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.29689986
58IGF1R_20145208_ChIP-Seq_DFB_Human1.29671169
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.29341894
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28765322
61AHR_22903824_ChIP-Seq_MCF-7_Human1.27904407
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25913879
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25773421
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.25597258
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25370237
66AR_25329375_ChIP-Seq_VCAP_Human1.23096513
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23025909
68P300_19829295_ChIP-Seq_ESCs_Human1.22723782
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21643051
70* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21397715
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21362140
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21345581
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21300949
74TP53_18474530_ChIP-ChIP_U2OS_Human1.20282468
75* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19824220
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19428195
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19373396
78TAF15_26573619_Chip-Seq_HEK293_Human1.15872548
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13901524
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13744344
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13518151
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13332488
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.13330405
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13100299
85* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12396081
86* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12396081
87TP53_16413492_ChIP-PET_HCT116_Human1.12385405
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12292046
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12096202
90* TCF4_23295773_ChIP-Seq_U87_Human1.11340519
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10707723
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.10495282
93EWS_26573619_Chip-Seq_HEK293_Human1.10409490
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09645009
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.09495250
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.09425446
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08901191
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08556139
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08467800
100* KDM2B_26808549_Chip-Seq_REH_Human1.07721599
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.07440637
102* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07256507
103* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06587277
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06441072
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06389760
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05876491
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05508803
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05508803
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04076376
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02889988
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.02040098
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01564548
113* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01197294
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.98822522
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97492191
116* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95967504
117RUNX2_22187159_ChIP-Seq_PCA_Human0.94388914
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.94272471
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94113945
120RNF2_27304074_Chip-Seq_NSC_Mouse0.93815023
121* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92844504
122* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91173218
123* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90103535
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.89020468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61301348
2MP0004270_analgesia3.96033192
3MP0003635_abnormal_synaptic_transmissio3.85058133
4MP0003880_abnormal_central_pattern3.50304918
5MP0002063_abnormal_learning/memory/cond3.16240105
6MP0000569_abnormal_digit_pigmentation2.82965277
7MP0009780_abnormal_chondrocyte_physiolo2.76523419
8MP0009745_abnormal_behavioral_response2.74574214
9MP0005423_abnormal_somatic_nervous2.70695749
10MP0001968_abnormal_touch/_nociception2.69121166
11MP0002734_abnormal_mechanical_nocicepti2.68306375
12MP0002064_seizures2.53250142
13MP0009046_muscle_twitch2.40108873
14MP0002572_abnormal_emotion/affect_behav2.39733692
15MP0004858_abnormal_nervous_system2.23407902
16MP0002735_abnormal_chemical_nociception2.22893649
17* MP0000778_abnormal_nervous_system2.22589699
18MP0001486_abnormal_startle_reflex2.18807554
19MP0002909_abnormal_adrenal_gland2.01073918
20* MP0004811_abnormal_neuron_physiology1.99996237
21MP0002272_abnormal_nervous_system1.99276610
22MP0002184_abnormal_innervation1.97228238
23MP0002733_abnormal_thermal_nociception1.96627950
24MP0003787_abnormal_imprinting1.87456472
25MP0002736_abnormal_nociception_after1.81594650
26MP0001970_abnormal_pain_threshold1.79806281
27MP0008569_lethality_at_weaning1.75963370
28MP0002067_abnormal_sensory_capabilities1.75455924
29MP0001440_abnormal_grooming_behavior1.71426571
30MP0002557_abnormal_social/conspecific_i1.69262168
31MP0000955_abnormal_spinal_cord1.66544659
32MP0002638_abnormal_pupillary_reflex1.63868230
33MP0001501_abnormal_sleep_pattern1.63630716
34MP0004885_abnormal_endolymph1.62196458
35MP0005386_behavior/neurological_phenoty1.60580796
36MP0004924_abnormal_behavior1.60580796
37MP0002882_abnormal_neuron_morphology1.50815532
38MP0001984_abnormal_olfaction1.41402323
39MP0003879_abnormal_hair_cell1.40804606
40MP0002822_catalepsy1.37516968
41* MP0002152_abnormal_brain_morphology1.27955253
42MP0005187_abnormal_penis_morphology1.26833705
43MP0002066_abnormal_motor_capabilities/c1.25422970
44MP0003329_amyloid_beta_deposits1.25173593
45MP0005646_abnormal_pituitary_gland1.23538392
46MP0003283_abnormal_digestive_organ1.21318672
47MP0003633_abnormal_nervous_system1.20906293
48MP0001299_abnormal_eye_distance/1.19646913
49MP0005645_abnormal_hypothalamus_physiol1.19214336
50MP0003122_maternal_imprinting1.17276574
51MP0006276_abnormal_autonomic_nervous1.15862620
52MP0001529_abnormal_vocalization1.11657484
53MP0001502_abnormal_circadian_rhythm1.06536045
54MP0003136_yellow_coat_color1.05253971
55MP0010368_abnormal_lymphatic_system1.04586050
56MP0008961_abnormal_basal_metabolism1.01343839
57MP0000631_abnormal_neuroendocrine_gland1.00912907
58MP0003631_nervous_system_phenotype1.00845694
59MP0005499_abnormal_olfactory_system1.00259093
60MP0005394_taste/olfaction_phenotype1.00259093
61MP0001879_abnormal_lymphatic_vessel0.98543632
62MP0004142_abnormal_muscle_tone0.98253849
63MP0003634_abnormal_glial_cell0.97155213
64MP0003861_abnormal_nervous_system0.96946080
65MP0005623_abnormal_meninges_morphology0.96704141
66MP0000516_abnormal_urinary_system0.95423410
67MP0005367_renal/urinary_system_phenotyp0.95423410
68MP0003942_abnormal_urinary_system0.95059059
69MP0002234_abnormal_pharynx_morphology0.94249185
70MP0003385_abnormal_body_wall0.93738897
71MP0005551_abnormal_eye_electrophysiolog0.92992514
72MP0004233_abnormal_muscle_weight0.92566946
73MP0005171_absent_coat_pigmentation0.91702899
74MP0006072_abnormal_retinal_apoptosis0.90480419
75MP0003935_abnormal_craniofacial_develop0.88568945
76MP0004510_myositis0.86002075
77MP0005257_abnormal_intraocular_pressure0.85898290
78MP0003755_abnormal_palate_morphology0.85534868
79MP0010234_abnormal_vibrissa_follicle0.83306513
80MP0004085_abnormal_heartbeat0.83136990
81MP0000013_abnormal_adipose_tissue0.82491300
82MP0002229_neurodegeneration0.82148563
83MP0003303_peritoneal_inflammation0.81689108
84MP0010386_abnormal_urinary_bladder0.81224101
85MP0002102_abnormal_ear_morphology0.80930149
86MP0000462_abnormal_digestive_system0.80080670
87MP0001177_atelectasis0.79595163
88MP0002233_abnormal_nose_morphology0.79444827
89MP0005409_darkened_coat_color0.79429522
90MP0003937_abnormal_limbs/digits/tail_de0.78748744
91MP0005503_abnormal_tendon_morphology0.78747729
92MP0002752_abnormal_somatic_nervous0.77597189
93MP0001188_hyperpigmentation0.75723993
94MP0002069_abnormal_eating/drinking_beha0.75182249
95MP0005174_abnormal_tail_pigmentation0.74226079
96MP0003632_abnormal_nervous_system0.74080220
97MP0009250_abnormal_appendicular_skeleto0.73683455
98MP0009053_abnormal_anal_canal0.72865342
99MP0005195_abnormal_posterior_eye0.72617997
100MP0003690_abnormal_glial_cell0.71910360
101MP0002090_abnormal_vision0.71757089
102MP0003121_genomic_imprinting0.71749038
103MP0006292_abnormal_olfactory_placode0.70300093
104MP0003890_abnormal_embryonic-extraembry0.70160880
105MP0000534_abnormal_ureter_morphology0.70085560
106MP0005248_abnormal_Harderian_gland0.67646900
107MP0004742_abnormal_vestibular_system0.67622277
108MP0001963_abnormal_hearing_physiology0.67122652
109MP0001348_abnormal_lacrimal_gland0.67031592
110MP0000537_abnormal_urethra_morphology0.66509500
111MP0000751_myopathy0.66274856
112MP0004145_abnormal_muscle_electrophysio0.65094005
113MP0003172_abnormal_lysosome_physiology0.64632409
114MP0003045_fibrosis0.63411360
115MP0004215_abnormal_myocardial_fiber0.62555879
116MP0005253_abnormal_eye_physiology0.61252344
117MP0004484_altered_response_of0.59892433
118MP0002751_abnormal_autonomic_nervous0.59512116
119MP0003137_abnormal_impulse_conducting0.59227087
120MP0001943_abnormal_respiration0.59111413
121MP0002081_perinatal_lethality0.58677324
122MP0003119_abnormal_digestive_system0.58548664
123MP0003183_abnormal_peptide_metabolism0.57750172
124MP0002877_abnormal_melanocyte_morpholog0.57093467
125MP0010769_abnormal_survival0.56064639
126MP0010770_preweaning_lethality0.54440043
127MP0002082_postnatal_lethality0.54440043

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.12032854
2Focal motor seizures (HP:0011153)5.02724530
3Focal seizures (HP:0007359)4.31486635
4Visual hallucinations (HP:0002367)4.10804124
5Action tremor (HP:0002345)3.78313579
6Papilledema (HP:0001085)3.73985282
7Progressive cerebellar ataxia (HP:0002073)3.59738588
8Epileptic encephalopathy (HP:0200134)3.51199765
9Excessive salivation (HP:0003781)3.20033154
10Drooling (HP:0002307)3.20033154
11Supranuclear gaze palsy (HP:0000605)3.06044117
12Febrile seizures (HP:0002373)3.04825557
13Atonic seizures (HP:0010819)3.02784726
14Ankle clonus (HP:0011448)2.98808180
15Genetic anticipation (HP:0003743)2.97503640
16Absence seizures (HP:0002121)2.92951956
17Mutism (HP:0002300)2.91520242
18Broad-based gait (HP:0002136)2.90011080
19Termporal pattern (HP:0011008)2.76315320
20Insidious onset (HP:0003587)2.76315320
21Truncal ataxia (HP:0002078)2.75175762
22Urinary bladder sphincter dysfunction (HP:0002839)2.73899771
23Impaired vibration sensation in the lower limbs (HP:0002166)2.66376521
24Poor eye contact (HP:0000817)2.65376535
25Depression (HP:0000716)2.60206175
26Generalized tonic-clonic seizures (HP:0002069)2.59557107
27Agitation (HP:0000713)2.55541083
28Macroorchidism (HP:0000053)2.54152249
29Dialeptic seizures (HP:0011146)2.53485243
30Inappropriate behavior (HP:0000719)2.52878583
31Urinary urgency (HP:0000012)2.49013594
32Abnormality of the lower motor neuron (HP:0002366)2.40275188
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39915557
34Short 4th metacarpal (HP:0010044)2.39915557
35Aqueductal stenosis (HP:0002410)2.39670494
36Amyotrophic lateral sclerosis (HP:0007354)2.39614414
37Gaze-evoked nystagmus (HP:0000640)2.39521013
38Impaired social interactions (HP:0000735)2.39116294
39Abnormal social behavior (HP:0012433)2.39116294
40Pointed chin (HP:0000307)2.37424317
41Abnormality of the ischium (HP:0003174)2.36225763
42Impaired smooth pursuit (HP:0007772)2.36206382
43Stereotypic behavior (HP:0000733)2.34501548
44Insomnia (HP:0100785)2.29327830
45Protruding tongue (HP:0010808)2.26813791
46Amblyopia (HP:0000646)2.26705321
47Dysdiadochokinesis (HP:0002075)2.22754337
48Cutaneous finger syndactyly (HP:0010554)2.22174789
49Hemiparesis (HP:0001269)2.21148593
50Overgrowth (HP:0001548)2.19046901
51Hyperacusis (HP:0010780)2.16962739
52Dysmetria (HP:0001310)2.16139062
53Postural instability (HP:0002172)2.14968718
54Abnormality of salivation (HP:0100755)2.11080771
55Abnormality of the corticospinal tract (HP:0002492)2.08842834
56Epileptiform EEG discharges (HP:0011182)2.08772383
57Volvulus (HP:0002580)2.08130763
58Spastic gait (HP:0002064)2.07435020
59Abnormality of ocular smooth pursuit (HP:0000617)2.07107992
60EEG with generalized epileptiform discharges (HP:0011198)2.05786868
61Obstructive sleep apnea (HP:0002870)2.04681601
62Papillary thyroid carcinoma (HP:0002895)2.03678160
63Apathy (HP:0000741)2.03436420
64Hyperventilation (HP:0002883)2.03308262
65Hypoplastic ischia (HP:0003175)2.01911356
66Hypsarrhythmia (HP:0002521)2.00452906
67Anxiety (HP:0000739)2.00160872
68Elfin facies (HP:0004428)2.00054975
69Abnormal eating behavior (HP:0100738)1.99956093
70Ankyloglossia (HP:0010296)1.96202807
71Hepatoblastoma (HP:0002884)1.95228648
72Pheochromocytoma (HP:0002666)1.93668884
73Abnormality of the 4th metacarpal (HP:0010012)1.93259500
74Absent speech (HP:0001344)1.93255413
75Diplopia (HP:0000651)1.92867046
76Abnormality of binocular vision (HP:0011514)1.92867046
77Lower limb muscle weakness (HP:0007340)1.92285425
78Torticollis (HP:0000473)1.90458736
79Dysmetric saccades (HP:0000641)1.89799647
80Obsessive-compulsive behavior (HP:0000722)1.89011279
81Pulmonic stenosis (HP:0001642)1.85774637
82Intention tremor (HP:0002080)1.84825680
83Limb dystonia (HP:0002451)1.84700063
84Progressive inability to walk (HP:0002505)1.83986127
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83468379
86Hemiplegia (HP:0002301)1.82577478
87Neoplasm of the adrenal cortex (HP:0100641)1.81974927
88Mild short stature (HP:0003502)1.81543414
89Intellectual disability, profound (HP:0002187)1.80461534
90Intestinal atresia (HP:0011100)1.79164038
91Gait imbalance (HP:0002141)1.79150549
92Cutaneous syndactyly (HP:0012725)1.78890039
93Sacral dimple (HP:0000960)1.78248488
94Diminished motivation (HP:0000745)1.78038752
95Lower limb amyotrophy (HP:0007210)1.77964251
96Inability to walk (HP:0002540)1.77392166
97Cerebral inclusion bodies (HP:0100314)1.77334222
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77219893
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75512369
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.75512369
101Lower limb asymmetry (HP:0100559)1.73331782
102Bradykinesia (HP:0002067)1.73210086
103Subacute progressive viral hepatitis (HP:0006572)1.72407482
104Morphological abnormality of the middle ear (HP:0008609)1.71646364
105Short chin (HP:0000331)1.71042485
106Overriding aorta (HP:0002623)1.71039978
107Hypoplasia of the brainstem (HP:0002365)1.70994744
108Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70994744
109Open mouth (HP:0000194)1.70726805
110Widely spaced teeth (HP:0000687)1.70273367
111Blue irides (HP:0000635)1.68399092
112Abnormality of the antihelix (HP:0009738)1.67588974
113Postural tremor (HP:0002174)1.67366528
114Sporadic (HP:0003745)1.67065353
115Scanning speech (HP:0002168)1.66124093
116Neoplasm of the heart (HP:0100544)1.65809063
117Round face (HP:0000311)1.65264726
118Bundle branch block (HP:0011710)1.65009066
119Exotropia (HP:0000577)1.64749032
120Annular pancreas (HP:0001734)1.63540278
121Renovascular hypertension (HP:0100817)1.63499917
122Focal dystonia (HP:0004373)1.62906214
123Impaired vibratory sensation (HP:0002495)1.62560705
124Shallow orbits (HP:0000586)1.62522355
125Fetal akinesia sequence (HP:0001989)1.62330767
126Renal duplication (HP:0000075)1.62087762
127Pachygyria (HP:0001302)1.61363725
128Chronic hepatic failure (HP:0100626)1.60170874
129Optic nerve hypoplasia (HP:0000609)1.58427267
130Neuroendocrine neoplasm (HP:0100634)1.57820122
131Tented upper lip vermilion (HP:0010804)1.55837350
132Hypoplastic nipples (HP:0002557)1.55296782
133Wide anterior fontanel (HP:0000260)1.55084728
134Shawl scrotum (HP:0000049)1.53263876
135Genital tract atresia (HP:0001827)1.53209981
136Truncal obesity (HP:0001956)1.52703449
137Renal hypoplasia (HP:0000089)1.51023151
138Neonatal short-limb short stature (HP:0008921)1.51001186
139Broad metatarsal (HP:0001783)1.49837993
140Gastroesophageal reflux (HP:0002020)1.49369365
141Heterotopia (HP:0002282)1.46735690
142Cupped ear (HP:0000378)1.46193697
143Vaginal atresia (HP:0000148)1.45999348
144Short foot (HP:0001773)1.45648091
145Prolonged QT interval (HP:0001657)1.45564010
146Fair hair (HP:0002286)1.45451631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.15174943
2MAP3K93.93494591
3NTRK33.82427018
4MAP3K42.92805743
5EPHA42.87845725
6MINK12.72346663
7PRKD32.62096579
8NTRK22.22060626
9PAK62.20805768
10DAPK22.14430815
11KSR22.10628998
12MAP2K72.00775369
13KSR11.97256504
14CAMKK11.93027493
15MAP3K21.91551124
16NTRK11.67517470
17SIK21.64706378
18AKT31.64269838
19MAPK131.58546557
20MAP2K41.55800412
21CDK51.47825909
22LATS21.44646836
23RET1.43348413
24PHKG11.38361388
25PHKG21.38361388
26TYRO31.26083900
27TAOK11.25345499
28RIPK11.21860909
29TRPM71.21672526
30BCR1.21540983
31PLK21.20662196
32DAPK11.19231350
33RIPK41.15387613
34PINK11.15021000
35ERBB31.11145488
36PAK31.10865482
37STK381.10051982
38MARK21.08302533
39SCYL21.07482013
40EEF2K1.07421200
41EPHA31.02913827
42CAMK1G1.00834426
43UHMK11.00344264
44MAP3K121.00007940
45LATS10.99488805
46CAMKK20.94963153
47STK110.94962251
48ALK0.94302523
49CSNK1G20.94213836
50PRKCH0.93215036
51PKN10.90778688
52SGK30.89007139
53PRKCG0.87812452
54PRPF4B0.86963029
55SGK20.86919882
56GRK50.81819928
57DMPK0.80987322
58SGK4940.80249393
59SGK2230.80249393
60PDGFRA0.79994951
61LMTK20.79683879
62TIE10.78904981
63YES10.78552625
64TNIK0.78169861
65CDK180.77905195
66FGFR20.76167005
67CDK140.75976187
68CDK150.75715474
69PNCK0.75267274
70BMPR1B0.73714007
71RPS6KA20.73263407
72CDK30.71605083
73SGK10.71558501
74CAMK10.71027455
75DYRK1A0.70071229
76WNK30.68224981
77FES0.68082969
78MAP3K60.66286760
79CDC42BPA0.63119442
80CDK11A0.62782634
81CDK190.62684390
82CAMK2A0.61470944
83DYRK20.58843868
84CASK0.58765543
85RAF10.57619367
86STK38L0.56237282
87TRIB30.55073982
88ROCK10.54994951
89MAP3K70.54577497
90RPS6KA30.54332678
91PTK2B0.53539696
92ROCK20.53306489
93HIPK20.53219304
94CSNK1G10.52762732
95MAPK100.51738385
96FYN0.51594861
97WNK10.51361401
98CAMK40.50155875
99FER0.49141407
100BRD40.48388622
101FGFR30.47975336
102EPHB20.47328752
103DDR20.45164076
104TRIM280.44410377
105INSRR0.44354607
106PTK20.44050409
107MAP3K10.43881425
108PKN20.43293694
109CSNK1A1L0.43115981
110MAPK120.42778444
111CAMK1D0.42741777
112ICK0.42697691
113MAP4K20.42465707
114PRKG10.42211206
115PDGFRB0.41875333
116CCNB10.41066599
117* PRKCZ0.40869103
118PRKAA10.40371317
119CSNK1G30.38913833
120ADRBK20.38533666
121* PDK10.38199914
122FRK0.37739517
123PRKCE0.37217438
124CAMK2B0.36827785
125MAP3K130.36533194
126MAPK80.33784025
127CAMK2D0.33276473
128ERBB20.33167533

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.55976541
2Synaptic vesicle cycle_Homo sapiens_hsa047212.46956321
3Olfactory transduction_Homo sapiens_hsa047402.39606781
4Long-term potentiation_Homo sapiens_hsa047202.37583463
5Circadian entrainment_Homo sapiens_hsa047132.36635339
6Glutamatergic synapse_Homo sapiens_hsa047242.14571421
7GABAergic synapse_Homo sapiens_hsa047272.10016472
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07188703
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02854933
10Morphine addiction_Homo sapiens_hsa050322.02079501
11Amphetamine addiction_Homo sapiens_hsa050312.01590441
12* Dopaminergic synapse_Homo sapiens_hsa047281.93902784
13Insulin secretion_Homo sapiens_hsa049111.86884643
14* Cholinergic synapse_Homo sapiens_hsa047251.84106404
15Salivary secretion_Homo sapiens_hsa049701.73348196
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70356590
17Gastric acid secretion_Homo sapiens_hsa049711.61400070
18Type II diabetes mellitus_Homo sapiens_hsa049301.58711016
19Oxytocin signaling pathway_Homo sapiens_hsa049211.56846323
20* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54608820
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53043860
22Renin secretion_Homo sapiens_hsa049241.51111057
23Long-term depression_Homo sapiens_hsa047301.47332409
24GnRH signaling pathway_Homo sapiens_hsa049121.44264574
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44105778
26Cocaine addiction_Homo sapiens_hsa050301.40726253
27* Glioma_Homo sapiens_hsa052141.39850059
28Axon guidance_Homo sapiens_hsa043601.39597849
29Gap junction_Homo sapiens_hsa045401.37135532
30Taste transduction_Homo sapiens_hsa047421.33369696
31* Estrogen signaling pathway_Homo sapiens_hsa049151.29087199
32Serotonergic synapse_Homo sapiens_hsa047261.29062020
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23797325
34Dorso-ventral axis formation_Homo sapiens_hsa043201.23358423
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21766332
36Calcium signaling pathway_Homo sapiens_hsa040201.21620991
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20734646
38* ErbB signaling pathway_Homo sapiens_hsa040121.18918695
39* cAMP signaling pathway_Homo sapiens_hsa040241.18413554
40Hedgehog signaling pathway_Homo sapiens_hsa043401.14574650
41Phototransduction_Homo sapiens_hsa047441.14553745
42Melanogenesis_Homo sapiens_hsa049161.11541957
43* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09290196
44Oocyte meiosis_Homo sapiens_hsa041141.04469526
45* Neurotrophin signaling pathway_Homo sapiens_hsa047221.03704237
46* Endometrial cancer_Homo sapiens_hsa052130.98664139
47ECM-receptor interaction_Homo sapiens_hsa045120.98294273
48* mTOR signaling pathway_Homo sapiens_hsa041500.97155078
49* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92682204
50* Phospholipase D signaling pathway_Homo sapiens_hsa040720.92146048
51* Colorectal cancer_Homo sapiens_hsa052100.88972230
52Dilated cardiomyopathy_Homo sapiens_hsa054140.88569012
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.87685968
54Adherens junction_Homo sapiens_hsa045200.87371989
55* MAPK signaling pathway_Homo sapiens_hsa040100.86912183
56Basal cell carcinoma_Homo sapiens_hsa052170.85321812
57* Choline metabolism in cancer_Homo sapiens_hsa052310.84645186
58* VEGF signaling pathway_Homo sapiens_hsa043700.82703996
59* Renal cell carcinoma_Homo sapiens_hsa052110.82192846
60* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80158272
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75594006
62Thyroid hormone synthesis_Homo sapiens_hsa049180.75010322
63Alcoholism_Homo sapiens_hsa050340.74799671
64* Rap1 signaling pathway_Homo sapiens_hsa040150.73515134
65Endocytosis_Homo sapiens_hsa041440.73004263
66* Ras signaling pathway_Homo sapiens_hsa040140.72993637
67Wnt signaling pathway_Homo sapiens_hsa043100.72964412
68* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71764373
69* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71360782
70Pancreatic secretion_Homo sapiens_hsa049720.71228515
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70901276
72* Non-small cell lung cancer_Homo sapiens_hsa052230.70458041
73MicroRNAs in cancer_Homo sapiens_hsa052060.70388785
74* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69370163
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67529754
76Circadian rhythm_Homo sapiens_hsa047100.64593145
77* Sphingolipid signaling pathway_Homo sapiens_hsa040710.64361098
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64120757
79* Tight junction_Homo sapiens_hsa045300.63913762
80TGF-beta signaling pathway_Homo sapiens_hsa043500.63349776
81* Prolactin signaling pathway_Homo sapiens_hsa049170.62779870
82Ovarian steroidogenesis_Homo sapiens_hsa049130.61969689
83* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61551022
84* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61250172
85* Insulin signaling pathway_Homo sapiens_hsa049100.61056897
86* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60929678
87* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59782971
88* Glucagon signaling pathway_Homo sapiens_hsa049220.59612801
89* Chemokine signaling pathway_Homo sapiens_hsa040620.59416837
90Inositol phosphate metabolism_Homo sapiens_hsa005620.59273536
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58130258
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58124537
93* FoxO signaling pathway_Homo sapiens_hsa040680.57156034
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57114296
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56971650
96Collecting duct acid secretion_Homo sapiens_hsa049660.56932093
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56789480
98* Chronic myeloid leukemia_Homo sapiens_hsa052200.56217466
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56034147
100Hippo signaling pathway_Homo sapiens_hsa043900.55853627
101* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54403834
102* Melanoma_Homo sapiens_hsa052180.53849495
103Protein digestion and absorption_Homo sapiens_hsa049740.53795836
104Bile secretion_Homo sapiens_hsa049760.52867421
105Vibrio cholerae infection_Homo sapiens_hsa051100.52756829
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52414782
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52366780
108* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50559306
109Lysine degradation_Homo sapiens_hsa003100.50350241
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49965474
111* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49366774
112Type I diabetes mellitus_Homo sapiens_hsa049400.49286858
113* Focal adhesion_Homo sapiens_hsa045100.48819398
114* Proteoglycans in cancer_Homo sapiens_hsa052050.48470374
115* Pancreatic cancer_Homo sapiens_hsa052120.48048667
116* Platelet activation_Homo sapiens_hsa046110.47821885
117Amoebiasis_Homo sapiens_hsa051460.47169292
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46007525
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45540963
120* Pathways in cancer_Homo sapiens_hsa052000.44471899
121* AMPK signaling pathway_Homo sapiens_hsa041520.43676266

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