AKTIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.71146399
2retinal cone cell development (GO:0046549)4.43921586
3neuronal action potential propagation (GO:0019227)4.30972445
4neuron cell-cell adhesion (GO:0007158)4.29718181
5synaptic vesicle exocytosis (GO:0016079)4.20083853
6regulation of synaptic vesicle exocytosis (GO:2000300)4.13919983
7synaptic vesicle maturation (GO:0016188)4.12579188
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03511395
9presynaptic membrane assembly (GO:0097105)4.01940585
10axon ensheathment in central nervous system (GO:0032291)3.98111549
11central nervous system myelination (GO:0022010)3.98111549
12presynaptic membrane organization (GO:0097090)3.83651020
13regulation of synaptic vesicle transport (GO:1902803)3.83297894
14glutamate secretion (GO:0014047)3.78757869
15vocalization behavior (GO:0071625)3.70297924
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65922177
17protein localization to synapse (GO:0035418)3.53700140
18long-chain fatty acid biosynthetic process (GO:0042759)3.51208801
19regulation of meiosis I (GO:0060631)3.46553924
20DNA methylation involved in gamete generation (GO:0043046)3.46333532
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42974229
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35736140
23proline transport (GO:0015824)3.35602511
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32442095
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.30931102
26sarcoplasmic reticulum calcium ion transport (GO:0070296)3.26988684
27positive regulation of meiosis (GO:0045836)3.25311504
28postsynaptic membrane organization (GO:0001941)3.25220519
29transferrin transport (GO:0033572)3.24306593
30axoneme assembly (GO:0035082)3.23910560
31regulation of cell communication by electrical coupling (GO:0010649)3.20587641
32neurotransmitter secretion (GO:0007269)3.20413373
33transmission of nerve impulse (GO:0019226)3.19956488
34neuron-neuron synaptic transmission (GO:0007270)3.19508292
35protein polyglutamylation (GO:0018095)3.18366260
36regulation of relaxation of muscle (GO:1901077)3.15704724
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15537822
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.14890981
39potassium ion import (GO:0010107)3.14013352
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.12757997
41ATP hydrolysis coupled proton transport (GO:0015991)3.12657426
42energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12657426
43muscle filament sliding (GO:0030049)3.11336028
44actin-myosin filament sliding (GO:0033275)3.11336028
45positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.10939450
46synaptic transmission, glutamatergic (GO:0035249)3.10102409
47positive regulation of meiotic cell cycle (GO:0051446)3.08279144
48neurofilament cytoskeleton organization (GO:0060052)3.06595398
49regulation of membrane repolarization (GO:0060306)3.04211900
50neurotransmitter transport (GO:0006836)3.04090942
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.04089479
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.02693383
53regulation of neuronal synaptic plasticity (GO:0048168)3.02505950
54ferric iron transport (GO:0015682)3.00593453
55trivalent inorganic cation transport (GO:0072512)3.00593453
56regulation of glutamate receptor signaling pathway (GO:1900449)2.99658126
57negative regulation of neurotransmitter transport (GO:0051589)2.99087256
58neurotransmitter-gated ion channel clustering (GO:0072578)2.98851055
59locomotory exploration behavior (GO:0035641)2.97568950
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96629961
61neuromuscular process controlling posture (GO:0050884)2.95124822
62startle response (GO:0001964)2.94993546
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94221444
64inositol phosphate catabolic process (GO:0071545)2.92949714
65positive regulation of membrane potential (GO:0045838)2.91690842
66epithelial cilium movement (GO:0003351)2.91094461
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.91000140
68phosphorylated carbohydrate dephosphorylation (GO:0046838)2.88513897
69inositol phosphate dephosphorylation (GO:0046855)2.88513897
70neuromuscular synaptic transmission (GO:0007274)2.88240213
71membrane depolarization during action potential (GO:0086010)2.87600752
72adaptation of signaling pathway (GO:0023058)2.86372994
73neurotransmitter uptake (GO:0001504)2.86274377
74detection of calcium ion (GO:0005513)2.84962734
75deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84861401
76adult walking behavior (GO:0007628)2.84843019
77calcium ion-dependent exocytosis (GO:0017156)2.84840091
78regulation of neurotransmitter secretion (GO:0046928)2.84536553
79regulation of skeletal muscle contraction (GO:0014819)2.83669188
80cytidine metabolic process (GO:0046087)2.82720630
81cytidine catabolic process (GO:0006216)2.82720630
82cytidine deamination (GO:0009972)2.82720630
83L-amino acid import (GO:0043092)2.82217115
84relaxation of smooth muscle (GO:0044557)2.80671371
85regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80610319
86neuronal action potential (GO:0019228)2.80535167
87cilium or flagellum-dependent cell motility (GO:0001539)2.78066711
88regulation of synapse structural plasticity (GO:0051823)2.74807019
89regulation of voltage-gated calcium channel activity (GO:1901385)2.74786905
90establishment of protein localization to Golgi (GO:0072600)2.74582930
91protein targeting to Golgi (GO:0000042)2.73310758
92membrane hyperpolarization (GO:0060081)2.73272014
93positive regulation of potassium ion transport (GO:0043268)2.73007925
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.72480401
95regulation of neurotransmitter transport (GO:0051588)2.72473299
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72387422
97protein neddylation (GO:0045116)2.72283487
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72001521
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71522036
100regulation of vesicle fusion (GO:0031338)2.70380246
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69802920
102relaxation of cardiac muscle (GO:0055119)2.69700680
103negative regulation of neurotransmitter secretion (GO:0046929)2.67041788
104long-term synaptic potentiation (GO:0060291)2.66312351
105glutamate receptor signaling pathway (GO:0007215)2.66149903
106short-chain fatty acid metabolic process (GO:0046459)2.65752971
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65449362
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64755978
109striatum development (GO:0021756)2.63961582
110multicellular organism reproduction (GO:0032504)2.63720580
111regulation of neurotransmitter levels (GO:0001505)2.63276402
112amino acid import (GO:0043090)2.61938303
113neuronal ion channel clustering (GO:0045161)2.61653713
114neuron recognition (GO:0008038)2.60413516
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59767563
116negative regulation of dendrite morphogenesis (GO:0050774)2.59588718
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.59500114
118relaxation of muscle (GO:0090075)2.58911141
119cilium movement (GO:0003341)2.58859227
120regulation of sodium ion transmembrane transporter activity (GO:2000649)2.58692864
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58490001
122actin-mediated cell contraction (GO:0070252)2.58111880
123regulation of acrosome reaction (GO:0060046)2.57334498
124response to pheromone (GO:0019236)2.56579808
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.56290297
126regulation of dopamine metabolic process (GO:0042053)2.55682761
127regulation of catecholamine metabolic process (GO:0042069)2.55682761
128cellular potassium ion homeostasis (GO:0030007)2.54448567
129respiratory electron transport chain (GO:0022904)2.51918726
130positive regulation of sodium ion transport (GO:0010765)2.51554261
131long-term memory (GO:0007616)2.51466117
132chaperone-mediated protein transport (GO:0072321)2.51299112
133synapse assembly (GO:0007416)2.51149655
134regulation of synaptic transmission, GABAergic (GO:0032228)2.51127403
135regulation of respiratory system process (GO:0044065)2.50860258
136auditory behavior (GO:0031223)2.50803782
137establishment of mitochondrion localization (GO:0051654)2.50673238
138regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49588628
139behavioral response to nicotine (GO:0035095)2.49109922
140positive regulation of synapse assembly (GO:0051965)2.48085867
141regulation of excitatory postsynaptic membrane potential (GO:0060079)2.48057271
142glycine transport (GO:0015816)2.47854317
143eye photoreceptor cell differentiation (GO:0001754)2.47827204
144photoreceptor cell differentiation (GO:0046530)2.47827204
145negative regulation of protein localization to cell surface (GO:2000009)2.47427215
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.47196838
147action potential (GO:0001508)2.46373151
148cAMP catabolic process (GO:0006198)2.46193940
149negative regulation of cation channel activity (GO:2001258)2.46142466
150electron transport chain (GO:0022900)2.46103840
151striated muscle contraction (GO:0006941)2.45628353
152adult locomotory behavior (GO:0008344)2.45500099
153fatty acid elongation (GO:0030497)2.45480850
154regulation of calcium ion-dependent exocytosis (GO:0017158)2.45183871
155synaptic vesicle endocytosis (GO:0048488)2.45030803
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.45009282
157vesicle docking involved in exocytosis (GO:0006904)2.44717660
158peristalsis (GO:0030432)2.44371089
159pyrimidine ribonucleoside catabolic process (GO:0046133)2.44258017
160dendrite development (GO:0016358)2.44063614
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44032895
162exploration behavior (GO:0035640)2.43767036
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41747405
164primary amino compound metabolic process (GO:1901160)2.40682368
165interkinetic nuclear migration (GO:0022027)2.39665425
166dopamine biosynthetic process (GO:0042416)2.38834551
167regulation of sodium ion transmembrane transport (GO:1902305)2.38107005
168auditory receptor cell stereocilium organization (GO:0060088)2.38072388
169negative regulation of cAMP-mediated signaling (GO:0043951)2.36871537
170phosphorelay signal transduction system (GO:0000160)2.35830109
171regulation of calcium ion transmembrane transport (GO:1903169)2.35522321
172regulation of calcium ion transmembrane transporter activity (GO:1901019)2.35522321
173myofibril assembly (GO:0030239)2.34877886
174cochlea development (GO:0090102)2.34698943

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.23433079
2GBX2_23144817_ChIP-Seq_PC3_Human3.80469962
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77158488
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67592280
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48886361
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42493137
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37099853
8TAF15_26573619_Chip-Seq_HEK293_Human2.18613505
9REST_21632747_ChIP-Seq_MESCs_Mouse2.16881053
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11202531
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10361679
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07199011
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.06769371
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05745627
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05532360
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04976444
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04976444
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01252459
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98233104
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97901253
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.96695517
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95392879
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.87549128
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86560978
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85722776
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83500468
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82404755
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.81043359
29VDR_22108803_ChIP-Seq_LS180_Human1.76216846
30* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70826021
31* RARB_27405468_Chip-Seq_BRAIN_Mouse1.69057912
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68632175
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63573697
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61179210
35AR_21572438_ChIP-Seq_LNCaP_Human1.60035514
36P300_19829295_ChIP-Seq_ESCs_Human1.58966743
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.58274286
38SMAD4_21799915_ChIP-Seq_A2780_Human1.54451371
39DROSHA_22980978_ChIP-Seq_HELA_Human1.52010083
40CBP_20019798_ChIP-Seq_JUKART_Human1.51650525
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51650525
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49736449
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48158788
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47793912
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45134405
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.44874333
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44707638
48RNF2_27304074_Chip-Seq_NSC_Mouse1.41597293
49ER_23166858_ChIP-Seq_MCF-7_Human1.40732898
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37554343
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.36478189
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35818088
53FUS_26573619_Chip-Seq_HEK293_Human1.33985800
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.33456027
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31784897
56BCAT_22108803_ChIP-Seq_LS180_Human1.30929123
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.29899638
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.28663750
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27689950
60CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26863851
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21811574
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.21492005
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.20365665
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19981229
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19606314
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.18896486
67IGF1R_20145208_ChIP-Seq_DFB_Human1.18179825
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17913618
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16355814
70STAT3_23295773_ChIP-Seq_U87_Human1.15717602
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.15616321
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15310866
73AHR_22903824_ChIP-Seq_MCF-7_Human1.14530925
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.14486049
75AR_25329375_ChIP-Seq_VCAP_Human1.14436826
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.13448461
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13172591
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13019952
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08549357
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08355084
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07256333
82P53_22387025_ChIP-Seq_ESCs_Mouse1.07193365
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07179881
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.07039342
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07033360
86TCF4_23295773_ChIP-Seq_U87_Human1.06917994
87ZNF274_21170338_ChIP-Seq_K562_Hela1.06448452
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06399541
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06399541
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05186265
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04901922
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04848071
93P300_18555785_Chip-Seq_ESCs_Mouse1.04098850
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03837998
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03630787
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.03353936
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03262145
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03235456
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02953541
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.02421325
101KDM2B_26808549_Chip-Seq_REH_Human1.02285145
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01979971
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.01903835
104TCF4_22108803_ChIP-Seq_LS180_Human1.01805744
105RUNX2_22187159_ChIP-Seq_PCA_Human1.01130354
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.00764427
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00640055
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99694360
109* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99251343
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.98948649
111JUN_21703547_ChIP-Seq_K562_Human0.98449990
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.98168469
113IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97632927
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97551269
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.97420489
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97181106
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96956408
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.95820294
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95687933
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94954868
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92308887
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92204746
123* NANOG_19829295_ChIP-Seq_ESCs_Human0.91901658
124* SOX2_19829295_ChIP-Seq_ESCs_Human0.91901658
125KLF4_18555785_Chip-Seq_ESCs_Mouse0.91754231
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.90598136
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.90572829
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90548585
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90272611
130SOX9_26525672_Chip-Seq_HEART_Mouse0.89068916
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88501694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.28382116
2MP0004859_abnormal_synaptic_plasticity3.70670757
3MP0004270_analgesia3.48184690
4MP0003646_muscle_fatigue3.29938170
5MP0003635_abnormal_synaptic_transmissio2.99392136
6MP0009046_muscle_twitch2.78298351
7MP0002734_abnormal_mechanical_nocicepti2.74690748
8MP0002064_seizures2.71815436
9MP0009745_abnormal_behavioral_response2.68677799
10MP0002272_abnormal_nervous_system2.66306069
11MP0001968_abnormal_touch/_nociception2.60803453
12MP0004043_abnormal_pH_regulation2.57328500
13MP0001486_abnormal_startle_reflex2.43935815
14MP0002063_abnormal_learning/memory/cond2.37952873
15MP0002735_abnormal_chemical_nociception2.30750832
16MP0005423_abnormal_somatic_nervous2.30237187
17MP0006276_abnormal_autonomic_nervous2.20342659
18MP0002736_abnormal_nociception_after2.17831614
19MP0002822_catalepsy2.14073054
20MP0002572_abnormal_emotion/affect_behav2.13071231
21MP0001905_abnormal_dopamine_level2.09675391
22MP0001529_abnormal_vocalization2.06548797
23MP0004142_abnormal_muscle_tone2.05941425
24MP0001188_hyperpigmentation2.02036004
25MP0002067_abnormal_sensory_capabilities1.89559226
26MP0001970_abnormal_pain_threshold1.88554711
27MP0004036_abnormal_muscle_relaxation1.84065858
28MP0000778_abnormal_nervous_system1.83404070
29MP0002733_abnormal_thermal_nociception1.82646008
30MP0005646_abnormal_pituitary_gland1.79768812
31MP0003011_delayed_dark_adaptation1.74954683
32MP0000920_abnormal_myelination1.73705163
33MP0001984_abnormal_olfaction1.70460560
34MP0001440_abnormal_grooming_behavior1.68784537
35MP0004885_abnormal_endolymph1.63860232
36MP0010386_abnormal_urinary_bladder1.63668220
37MP0001986_abnormal_taste_sensitivity1.62325208
38MP0005409_darkened_coat_color1.58930022
39MP0004484_altered_response_of1.58614775
40MP0008569_lethality_at_weaning1.57147370
41MP0005551_abnormal_eye_electrophysiolog1.56648114
42MP0005386_behavior/neurological_phenoty1.56403250
43MP0004924_abnormal_behavior1.56403250
44MP0002184_abnormal_innervation1.54348841
45MP0004130_abnormal_muscle_cell1.53019222
46MP0000955_abnormal_spinal_cord1.50376817
47MP0002557_abnormal_social/conspecific_i1.49241381
48MP0004742_abnormal_vestibular_system1.47732628
49MP0001501_abnormal_sleep_pattern1.45532137
50MP0005171_absent_coat_pigmentation1.45465220
51MP0000427_abnormal_hair_cycle1.43950493
52MP0002882_abnormal_neuron_morphology1.43445283
53MP0002229_neurodegeneration1.42359613
54MP0005645_abnormal_hypothalamus_physiol1.34279286
55MP0005620_abnormal_muscle_contractility1.33135870
56MP0002066_abnormal_motor_capabilities/c1.32329699
57MP0001485_abnormal_pinna_reflex1.32014904
58MP0005085_abnormal_gallbladder_physiolo1.29900307
59MP0003137_abnormal_impulse_conducting1.27386141
60MP0004084_abnormal_cardiac_muscle1.27148956
61MP0002928_abnormal_bile_duct1.27056793
62MP0004811_abnormal_neuron_physiology1.26761775
63MP0002638_abnormal_pupillary_reflex1.23640189
64MP0002269_muscular_atrophy1.23130213
65MP0003634_abnormal_glial_cell1.22371806
66MP0008789_abnormal_olfactory_epithelium1.22112676
67MP0006072_abnormal_retinal_apoptosis1.21425880
68MP0000569_abnormal_digit_pigmentation1.20062555
69MP0003136_yellow_coat_color1.18655355
70MP0003787_abnormal_imprinting1.17725303
71MP0003283_abnormal_digestive_organ1.16445503
72MP0002106_abnormal_muscle_physiology1.15869314
73MP0003329_amyloid_beta_deposits1.15569765
74MP0001963_abnormal_hearing_physiology1.15151416
75MP0002752_abnormal_somatic_nervous1.14965699
76MP0004145_abnormal_muscle_electrophysio1.14242497
77MP0001502_abnormal_circadian_rhythm1.13883064
78MP0005369_muscle_phenotype1.12118401
79MP0001177_atelectasis1.08737173
80MP0003252_abnormal_bile_duct1.07368957
81MP0002138_abnormal_hepatobiliary_system1.05666190
82MP0002876_abnormal_thyroid_physiology1.05332900
83MP0005167_abnormal_blood-brain_barrier1.05327243
84MP0003879_abnormal_hair_cell1.02556350
85MP0005253_abnormal_eye_physiology1.01648907
86MP0002909_abnormal_adrenal_gland1.01342579
87MP0003631_nervous_system_phenotype1.00449158
88MP0003633_abnormal_nervous_system0.99443005
89MP0009780_abnormal_chondrocyte_physiolo0.97245490
90MP0002127_abnormal_cardiovascular_syste0.95534910
91MP0000631_abnormal_neuroendocrine_gland0.95109123
92MP0008260_abnormal_autophagy0.94976155
93MP0003045_fibrosis0.94659700
94MP0004858_abnormal_nervous_system0.93046457
95MP0004087_abnormal_muscle_fiber0.91506160
96MP0002108_abnormal_muscle_morphology0.90551613
97MP0002972_abnormal_cardiac_muscle0.90368961
98MP0002837_dystrophic_cardiac_calcinosis0.89457217
99MP0003632_abnormal_nervous_system0.87949146
100MP0008877_abnormal_DNA_methylation0.87875502
101MP0002653_abnormal_ependyma_morphology0.86155104
102MP0002152_abnormal_brain_morphology0.86098323
103MP0003690_abnormal_glial_cell0.85745760
104MP0005394_taste/olfaction_phenotype0.85240376
105MP0005499_abnormal_olfactory_system0.85240376
106MP0002751_abnormal_autonomic_nervous0.83615761
107MP0000751_myopathy0.83388137
108MP0003122_maternal_imprinting0.82335056
109MP0003718_maternal_effect0.81998922
110MP0000013_abnormal_adipose_tissue0.81181989
111MP0002160_abnormal_reproductive_system0.80821798
112MP0000566_synostosis0.80498355
113MP0001299_abnormal_eye_distance/0.79910353
114MP0000750_abnormal_muscle_regeneration0.78833594
115MP0000372_irregular_coat_pigmentation0.77416197
116MP0000749_muscle_degeneration0.77274822
117MP0000026_abnormal_inner_ear0.76327186
118MP0002277_abnormal_respiratory_mucosa0.75636312
119MP0003698_abnormal_male_reproductive0.75521021
120MP0006036_abnormal_mitochondrial_physio0.75131379
121MP0004085_abnormal_heartbeat0.74181046
122MP0006292_abnormal_olfactory_placode0.73704286
123MP0005410_abnormal_fertilization0.72866748
124MP0003195_calcinosis0.72640783
125MP0001765_abnormal_ion_homeostasis0.72637465
126MP0002069_abnormal_eating/drinking_beha0.71690878
127MP0003950_abnormal_plasma_membrane0.71312722
128MP0001664_abnormal_digestion0.71256009
129MP0008872_abnormal_physiological_respon0.65962664
130MP0005379_endocrine/exocrine_gland_phen0.64749351
131MP0004215_abnormal_myocardial_fiber0.63802201

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.93038473
2Myokymia (HP:0002411)4.56338014
3Muscle fiber inclusion bodies (HP:0100299)4.29074493
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.99894842
5Nemaline bodies (HP:0003798)3.98729241
6Bundle branch block (HP:0011710)3.95207764
7Muscle hypertrophy of the lower extremities (HP:0008968)3.73331728
8Pheochromocytoma (HP:0002666)3.51371845
9Calf muscle hypertrophy (HP:0008981)3.43954794
10Exercise-induced myalgia (HP:0003738)3.40027002
11Epileptic encephalopathy (HP:0200134)3.38485055
12Atonic seizures (HP:0010819)3.35966298
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.29220770
14Absent/shortened dynein arms (HP:0200106)3.29220770
15Neuroendocrine neoplasm (HP:0100634)3.28198192
16Exercise-induced muscle cramps (HP:0003710)3.26720009
17Type II lissencephaly (HP:0007260)3.25889077
18Febrile seizures (HP:0002373)3.18392475
19Acute necrotizing encephalopathy (HP:0006965)3.14152203
20Increased circulating renin level (HP:0000848)3.11570513
21Focal seizures (HP:0007359)3.10437023
22Hypomagnesemia (HP:0002917)3.06627269
23Metabolic alkalosis (HP:0200114)3.02898996
24Ankle clonus (HP:0011448)3.02638164
25Methylmalonic acidemia (HP:0002912)3.00937417
26Hyporeflexia of lower limbs (HP:0002600)2.98070992
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.92493847
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.92493847
29Abnormality of magnesium homeostasis (HP:0004921)2.88950117
30Abnormal mitochondria in muscle tissue (HP:0008316)2.88372823
31Papilledema (HP:0001085)2.82806258
32Fetal akinesia sequence (HP:0001989)2.78468732
33Cerebral hypomyelination (HP:0006808)2.77436945
34Progressive macrocephaly (HP:0004481)2.76741431
35Progressive cerebellar ataxia (HP:0002073)2.76254769
36Visual hallucinations (HP:0002367)2.74619484
37Hypokalemic alkalosis (HP:0001949)2.71087573
38Hemiparesis (HP:0001269)2.70611261
39Gait imbalance (HP:0002141)2.65661395
40Syncope (HP:0001279)2.61737158
41Limb dystonia (HP:0002451)2.60245163
42Abnormality of the calf musculature (HP:0001430)2.59598061
43Medial flaring of the eyebrow (HP:0010747)2.57838804
44Renal cortical cysts (HP:0000803)2.57594149
45Muscle fiber splitting (HP:0003555)2.57592254
46Absence seizures (HP:0002121)2.57331389
47Mitochondrial inheritance (HP:0001427)2.55980070
48Nephrogenic diabetes insipidus (HP:0009806)2.55216671
49EMG: myopathic abnormalities (HP:0003458)2.52229455
50Abnormality of the corticospinal tract (HP:0002492)2.50370892
51Dialeptic seizures (HP:0011146)2.49276554
52Congenital primary aphakia (HP:0007707)2.46415539
53Supranuclear gaze palsy (HP:0000605)2.45829669
54Heart block (HP:0012722)2.45274159
55Hypothermia (HP:0002045)2.43692926
56Broad-based gait (HP:0002136)2.42358904
57Anxiety (HP:0000739)2.40671563
58Type 1 muscle fiber predominance (HP:0003803)2.40553660
59Vaginal atresia (HP:0000148)2.39293345
60Acute encephalopathy (HP:0006846)2.38912412
61Hyperaldosteronism (HP:0000859)2.38464243
62Cerebellar dysplasia (HP:0007033)2.38381647
63Chronic hepatic failure (HP:0100626)2.38319155
64Genital tract atresia (HP:0001827)2.37904826
65Progressive inability to walk (HP:0002505)2.34777309
66Abnormal hair whorl (HP:0010721)2.33695214
67Action tremor (HP:0002345)2.32985790
68Hepatocellular necrosis (HP:0001404)2.31718377
69Abnormal eating behavior (HP:0100738)2.31694116
70Sudden death (HP:0001699)2.31274242
71Retinal dysplasia (HP:0007973)2.28658943
72Generalized tonic-clonic seizures (HP:0002069)2.27905777
73Abnormality of the renal cortex (HP:0011035)2.24638900
74Distal arthrogryposis (HP:0005684)2.23381671
75Abnormal ciliary motility (HP:0012262)2.22352834
76Abnormal drinking behavior (HP:0030082)2.19776965
77Polydipsia (HP:0001959)2.19776965
78Increased CSF lactate (HP:0002490)2.19454939
79Poor suck (HP:0002033)2.18924599
80Hyperactive renin-angiotensin system (HP:0000841)2.18577350
81Retinal atrophy (HP:0001105)2.17997692
82Molar tooth sign on MRI (HP:0002419)2.17681174
83Abnormality of midbrain morphology (HP:0002418)2.17681174
84Polyuria (HP:0000103)2.16972343
85Gaze-evoked nystagmus (HP:0000640)2.16450167
86Pancreatic fibrosis (HP:0100732)2.15353858
87Spastic gait (HP:0002064)2.15066334
88Progressive external ophthalmoplegia (HP:0000590)2.14912368
89Dysmetria (HP:0001310)2.14374588
90Decreased circulating renin level (HP:0003351)2.13963901
91Optic disc pallor (HP:0000543)2.13427085
92Nephronophthisis (HP:0000090)2.10433338
93Abnormal rod and cone electroretinograms (HP:0008323)2.08575930
94Pancreatic cysts (HP:0001737)2.07157503
95Leukodystrophy (HP:0002415)2.06093829
96Scanning speech (HP:0002168)2.05807513
97Abnormal respiratory epithelium morphology (HP:0012253)2.04992685
98Abnormal respiratory motile cilium morphology (HP:0005938)2.04992685
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04192545
100Abnormality of vitamin B metabolism (HP:0004340)2.03919802
101Peripheral hypomyelination (HP:0007182)2.02802188
102Hypoplasia of the fovea (HP:0007750)2.02001693
103Aplasia/Hypoplasia of the fovea (HP:0008060)2.02001693
104Large for gestational age (HP:0001520)2.01708198
105Hyperkalemia (HP:0002153)2.00949861
106Abnormality of renin-angiotensin system (HP:0000847)2.00861639
107Polyphagia (HP:0002591)2.00098171
108EMG: neuropathic changes (HP:0003445)1.99563608
109Akinesia (HP:0002304)1.99238415
110Ventricular arrhythmia (HP:0004308)1.98765846
111Abnormal atrioventricular conduction (HP:0005150)1.97830086
112Rimmed vacuoles (HP:0003805)1.97467028
113Sleep apnea (HP:0010535)1.97205854
114Neck muscle weakness (HP:0000467)1.96179569
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94817952
116Central scotoma (HP:0000603)1.94585959
117Myoglobinuria (HP:0002913)1.93654117
118Increased serum pyruvate (HP:0003542)1.93496225
119Abnormality of glycolysis (HP:0004366)1.93496225
120Hyperventilation (HP:0002883)1.92854248
121Failure to thrive in infancy (HP:0001531)1.91928206
122Renal salt wasting (HP:0000127)1.91486985
123Abnormal urine output (HP:0012590)1.90986757
124Anterior segment dysgenesis (HP:0007700)1.89758895
125Abnormality of chloride homeostasis (HP:0011422)1.89170839
126Intention tremor (HP:0002080)1.88880275
127Abnormal EKG (HP:0003115)1.87473170
128Neurofibrillary tangles (HP:0002185)1.87000447
129Poor coordination (HP:0002370)1.85989494
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.85769394
131Parakeratosis (HP:0001036)1.85685722
132Abnormal respiratory motile cilium physiology (HP:0012261)1.83827845
133Split foot (HP:0001839)1.83600064
134Azoospermia (HP:0000027)1.83211663
135Abnormality of binocular vision (HP:0011514)1.82265974
136Diplopia (HP:0000651)1.82265974
137Muscle stiffness (HP:0003552)1.82253657
138Myotonia (HP:0002486)1.81706352
139Neoplasm of the peripheral nervous system (HP:0100007)1.80775121
140Abnormality of the renal medulla (HP:0100957)1.80764616
141CNS hypomyelination (HP:0003429)1.80648044
142Atrial fibrillation (HP:0005110)1.80050609
143Mutism (HP:0002300)1.80035233
144Abnormality of renal excretion (HP:0011036)1.79766013
145Ulnar claw (HP:0001178)1.79545244
146Specific learning disability (HP:0001328)1.78772422
147Termporal pattern (HP:0011008)1.78031608
148Insidious onset (HP:0003587)1.78031608
149Hemiplegia (HP:0002301)1.77484262
150Abnormality of the fovea (HP:0000493)1.77345077
151Prolonged QT interval (HP:0001657)1.77209569
152Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76618179
153Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76418310
154Methylmalonic aciduria (HP:0012120)1.76175052
155Inability to walk (HP:0002540)1.76008532
156Truncal ataxia (HP:0002078)1.75256212
157Stomatitis (HP:0010280)1.74924865
158Hepatic necrosis (HP:0002605)1.74797391
159Lower limb muscle weakness (HP:0007340)1.73875012
160Left ventricular hypertrophy (HP:0001712)1.73867776
161Bradykinesia (HP:0002067)1.73704593
162True hermaphroditism (HP:0010459)1.73258219
163Ventricular fibrillation (HP:0001663)1.73120151
164Postural instability (HP:0002172)1.73028374
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72771130
166Dysdiadochokinesis (HP:0002075)1.72756844
167Oligodactyly (hands) (HP:0001180)1.72546566
168Urinary bladder sphincter dysfunction (HP:0002839)1.69989731
169Abnormality of macular pigmentation (HP:0008002)1.69595138
170Congenital stationary night blindness (HP:0007642)1.69485176
171Impaired vibration sensation in the lower limbs (HP:0002166)1.69446810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.06247255
2CASK3.58578202
3OXSR13.27519111
4MARK13.07003857
5FRK3.00133369
6STK392.90440552
7NTRK32.37150656
8PINK12.34918718
9MAP3K132.33519969
10MAP2K72.29800795
11WNK42.08276366
12WNK32.05317330
13EPHA42.03596470
14MAP3K42.01362756
15MINK11.88697914
16SGK2231.86164898
17SGK4941.86164898
18TXK1.83517441
19PRPF4B1.83508105
20BCR1.82379123
21MAP3K121.79683517
22LIMK11.68441103
23MAPK131.66046567
24AKT31.64594803
25CDK191.62668095
26TAOK31.59371514
27TNIK1.58998763
28PRKD31.57762459
29MAP3K91.55242953
30NEK61.51224357
31IRAK21.44109461
32ARAF1.42577009
33PLK21.35222910
34GRK11.31387747
35IRAK31.30258227
36NME11.30256742
37MAPKAPK51.29489441
38UHMK11.26759452
39SGK21.24128268
40MARK31.23957550
41CAMK2B1.16059131
42NTRK11.15735394
43NLK1.14713899
44PNCK1.13133607
45WNK11.12583312
46CAMKK21.08648693
47MST41.07576924
48PIK3CA1.07401833
49IRAK11.05964596
50EPHA31.05343191
51PIK3CG1.02334733
52DAPK21.00200137
53FGFR20.99777705
54CDK50.99692000
55PHKG20.99456913
56PHKG10.99456913
57NTRK20.98346733
58TNK20.97794980
59STK110.97639688
60CAMK2D0.97355038
61BMPR20.97305530
62CAMK10.96730830
63GRK50.96136355
64LMTK20.93285577
65PTK2B0.91165741
66PAK60.90317756
67CAMK2A0.89064513
68MAP4K20.88131471
69BRAF0.88099771
70PBK0.87070952
71CAMK2G0.86631521
72PRKCE0.86438596
73PRKCQ0.86304613
74MAPK120.86197333
75PRKCH0.84368229
76SIK30.82783411
77STK160.80238605
78PRKCG0.80027531
79TRPM70.78629847
80MOS0.77066015
81TIE10.76999575
82PKN10.75859522
83DYRK20.74699191
84EIF2AK10.74318154
85ADRBK20.73216121
86STK380.72605929
87SGK30.71237306
88MAPKAPK30.70715087
89GRK70.70390783
90STK240.69702701
91MAP2K40.69614151
92CDK140.68193588
93MUSK0.68166491
94RAF10.66692636
95PRKG10.64211362
96STK38L0.64103701
97ROCK20.63870019
98BMPR1B0.62069671
99JAK10.61264261
100CDK180.60486365
101MAP3K20.60172759
102PDK20.59801308
103MAPK150.59672215
104PLK40.59373759
105TSSK60.58206182
106ERBB30.58101797
107FGFR30.57353377
108CSNK1G20.57243588
109CSNK1G30.57131173
110ZAP700.56703257
111ZAK0.56658942
112MAP2K60.55805523
113CAMK40.54286831
114CDK150.53939888
115PAK30.51608275
116EPHB10.51396714
117MAP3K70.50437896
118GRK60.49780869
119PRKCZ0.49551827
120FER0.49435589
121TLK10.48575670
122KSR10.48297627
123CAMKK10.47981802
124PDK40.47192217
125PDK30.47192217
126NEK10.46990516
127PDK10.46981679
128CDK11A0.46167469
129CDC42BPA0.45446938
130DYRK1A0.44835142
131MET0.44474856
132MAP2K10.44207524
133YES10.43440443
134SGK10.43077663
135ACVR1B0.42310513
136DAPK10.41538908
137CSNK1A10.40702611
138EIF2AK30.39859718
139KSR20.38732437
140ADRBK10.38334734
141PRKCI0.37912437
142PRKACA0.37158399
143ROCK10.35729721

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.80722072
2Collecting duct acid secretion_Homo sapiens_hsa049663.12427403
3Oxidative phosphorylation_Homo sapiens_hsa001903.12006107
4Nicotine addiction_Homo sapiens_hsa050332.96503145
5Parkinsons disease_Homo sapiens_hsa050122.53653519
6GABAergic synapse_Homo sapiens_hsa047272.36339652
7Olfactory transduction_Homo sapiens_hsa047402.21644479
8Vibrio cholerae infection_Homo sapiens_hsa051102.20803562
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20191223
10Phototransduction_Homo sapiens_hsa047442.15449591
11Morphine addiction_Homo sapiens_hsa050322.12905403
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96658988
13Alzheimers disease_Homo sapiens_hsa050101.95024596
14Circadian entrainment_Homo sapiens_hsa047131.94744320
15Glutamatergic synapse_Homo sapiens_hsa047241.83388132
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82453465
17Serotonergic synapse_Homo sapiens_hsa047261.80737090
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76755372
19Huntingtons disease_Homo sapiens_hsa050161.75323066
20Amphetamine addiction_Homo sapiens_hsa050311.75220589
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74675991
22Cardiac muscle contraction_Homo sapiens_hsa042601.74268232
23Dopaminergic synapse_Homo sapiens_hsa047281.70710577
24Caffeine metabolism_Homo sapiens_hsa002321.69421346
25Dorso-ventral axis formation_Homo sapiens_hsa043201.69247878
26Insulin secretion_Homo sapiens_hsa049111.67779783
27Taste transduction_Homo sapiens_hsa047421.67315275
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64481731
29Long-term potentiation_Homo sapiens_hsa047201.55658960
30Nitrogen metabolism_Homo sapiens_hsa009101.53389826
31Cholinergic synapse_Homo sapiens_hsa047251.50444271
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45801466
33Propanoate metabolism_Homo sapiens_hsa006401.45483226
34Protein export_Homo sapiens_hsa030601.40228214
35Linoleic acid metabolism_Homo sapiens_hsa005911.39159857
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.37634323
37Salivary secretion_Homo sapiens_hsa049701.37356226
38Gastric acid secretion_Homo sapiens_hsa049711.35537982
39ABC transporters_Homo sapiens_hsa020101.34843856
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32690462
41Cocaine addiction_Homo sapiens_hsa050301.32617511
42Fatty acid elongation_Homo sapiens_hsa000621.30836651
43Long-term depression_Homo sapiens_hsa047301.24410517
44Histidine metabolism_Homo sapiens_hsa003401.20836248
45Sphingolipid metabolism_Homo sapiens_hsa006001.20012599
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19333470
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18194141
48Ether lipid metabolism_Homo sapiens_hsa005651.17263784
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15159859
50Ovarian steroidogenesis_Homo sapiens_hsa049131.09661889
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09181573
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07738295
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07597374
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06521024
55Steroid biosynthesis_Homo sapiens_hsa001001.05515141
56Renin secretion_Homo sapiens_hsa049241.04810751
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04518835
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.04424848
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04121449
60Calcium signaling pathway_Homo sapiens_hsa040201.02910880
61Axon guidance_Homo sapiens_hsa043601.01362569
62Bile secretion_Homo sapiens_hsa049761.00482630
63Peroxisome_Homo sapiens_hsa041460.99020424
64Rheumatoid arthritis_Homo sapiens_hsa053230.96552696
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.93102971
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90420873
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89179876
68Arginine and proline metabolism_Homo sapiens_hsa003300.88880683
69Oxytocin signaling pathway_Homo sapiens_hsa049210.88393219
70Regulation of autophagy_Homo sapiens_hsa041400.85794329
71Arginine biosynthesis_Homo sapiens_hsa002200.85150860
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84497757
73Glucagon signaling pathway_Homo sapiens_hsa049220.83666520
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81836008
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81666488
76Fatty acid degradation_Homo sapiens_hsa000710.81502461
77Basal transcription factors_Homo sapiens_hsa030220.81065107
78beta-Alanine metabolism_Homo sapiens_hsa004100.78686018
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78134093
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77810229
81Gap junction_Homo sapiens_hsa045400.76405086
82Proteasome_Homo sapiens_hsa030500.76077446
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76052523
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75329772
85Pancreatic secretion_Homo sapiens_hsa049720.74053862
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73416416
87cAMP signaling pathway_Homo sapiens_hsa040240.73276114
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73027288
89Butanoate metabolism_Homo sapiens_hsa006500.72000344
90Sulfur metabolism_Homo sapiens_hsa009200.69928967
91ErbB signaling pathway_Homo sapiens_hsa040120.69468960
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69350063
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.68296732
94Chemical carcinogenesis_Homo sapiens_hsa052040.67805287
95Phagosome_Homo sapiens_hsa041450.65386098
96GnRH signaling pathway_Homo sapiens_hsa049120.64239850
97Retinol metabolism_Homo sapiens_hsa008300.64036102
98Mineral absorption_Homo sapiens_hsa049780.62902948
99Tight junction_Homo sapiens_hsa045300.62210173
100Tryptophan metabolism_Homo sapiens_hsa003800.61367099
101Melanogenesis_Homo sapiens_hsa049160.61348762
102T cell receptor signaling pathway_Homo sapiens_hsa046600.59995901
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57959742
104RNA polymerase_Homo sapiens_hsa030200.57565047
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57412953
106Oocyte meiosis_Homo sapiens_hsa041140.55405139
107Endocytosis_Homo sapiens_hsa041440.54235646
108Ras signaling pathway_Homo sapiens_hsa040140.53575755
109Type I diabetes mellitus_Homo sapiens_hsa049400.49380485
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.49234794
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48156737
112PPAR signaling pathway_Homo sapiens_hsa033200.47590754
113Alcoholism_Homo sapiens_hsa050340.45877525
114Thyroid hormone synthesis_Homo sapiens_hsa049180.45593307
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45323089
116Circadian rhythm_Homo sapiens_hsa047100.43544451
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.42395061
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.42308754
119Insulin signaling pathway_Homo sapiens_hsa049100.41892889
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41829335
121Lysosome_Homo sapiens_hsa041420.39997078
122Type II diabetes mellitus_Homo sapiens_hsa049300.38845698
123Inositol phosphate metabolism_Homo sapiens_hsa005620.38565474
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.35551843
125Purine metabolism_Homo sapiens_hsa002300.35234217
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34278693
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33686112
128Choline metabolism in cancer_Homo sapiens_hsa052310.33481654
129Melanoma_Homo sapiens_hsa052180.31499603
130MAPK signaling pathway_Homo sapiens_hsa040100.31438196
131Dilated cardiomyopathy_Homo sapiens_hsa054140.30365706
132Estrogen signaling pathway_Homo sapiens_hsa049150.29598736
133Renal cell carcinoma_Homo sapiens_hsa052110.29585306
134Arachidonic acid metabolism_Homo sapiens_hsa005900.29565375
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29290845
136Metabolic pathways_Homo sapiens_hsa011000.28260805
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27529261
138Wnt signaling pathway_Homo sapiens_hsa043100.25407143

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »