ALAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protoporphyrinogen IX biosynthetic process (GO:0006782)7.80229698
2* protoporphyrinogen IX metabolic process (GO:0046501)7.79901068
3L-phenylalanine catabolic process (GO:0006559)5.83837070
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.83837070
5* heme biosynthetic process (GO:0006783)5.83048104
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.70093525
7L-phenylalanine metabolic process (GO:0006558)5.70093525
8hemoglobin metabolic process (GO:0020027)5.66057296
9* porphyrin-containing compound biosynthetic process (GO:0006779)5.50506023
10aromatic amino acid family catabolic process (GO:0009074)5.21388771
11* heme metabolic process (GO:0042168)5.18883777
12cysteine metabolic process (GO:0006534)5.09116487
13glyoxylate metabolic process (GO:0046487)5.07259846
14lysine metabolic process (GO:0006553)4.95216817
15lysine catabolic process (GO:0006554)4.95216817
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.93289954
17* tetrapyrrole biosynthetic process (GO:0033014)4.91998069
18* porphyrin-containing compound metabolic process (GO:0006778)4.85454883
19tryptophan catabolic process (GO:0006569)4.67952299
20indole-containing compound catabolic process (GO:0042436)4.67952299
21indolalkylamine catabolic process (GO:0046218)4.67952299
22kynurenine metabolic process (GO:0070189)4.58937629
23sulfur amino acid catabolic process (GO:0000098)4.53866732
24bile acid biosynthetic process (GO:0006699)4.50230189
25tryptophan metabolic process (GO:0006568)4.42933401
26exogenous drug catabolic process (GO:0042738)4.39791324
27alpha-linolenic acid metabolic process (GO:0036109)4.38491891
28cellular ketone body metabolic process (GO:0046950)4.32155600
29epoxygenase P450 pathway (GO:0019373)4.29508616
30response to methylmercury (GO:0051597)4.28499200
31negative regulation of fibrinolysis (GO:0051918)4.27348772
32serine family amino acid catabolic process (GO:0009071)4.26109165
33glycine metabolic process (GO:0006544)4.18719339
34high-density lipoprotein particle remodeling (GO:0034375)4.17680248
35homocysteine metabolic process (GO:0050667)4.09153894
36urea cycle (GO:0000050)4.05866265
37urea metabolic process (GO:0019627)4.05866265
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05649553
39ethanol oxidation (GO:0006069)4.05310329
40plasma lipoprotein particle assembly (GO:0034377)4.04041195
41regulation of fibrinolysis (GO:0051917)4.02025010
42heme transport (GO:0015886)4.00440060
43serine family amino acid metabolic process (GO:0009069)3.95478588
44regulation of protein activation cascade (GO:2000257)3.94122651
45amino-acid betaine metabolic process (GO:0006577)3.93768331
46serine family amino acid biosynthetic process (GO:0009070)3.91434025
47ethanol metabolic process (GO:0006067)3.91102663
48aromatic amino acid family metabolic process (GO:0009072)3.88609001
49complement activation, alternative pathway (GO:0006957)3.87429337
50negative regulation of erythrocyte differentiation (GO:0045647)3.84482776
51bile acid metabolic process (GO:0008206)3.84332950
52very-low-density lipoprotein particle assembly (GO:0034379)3.84263547
53alpha-amino acid catabolic process (GO:1901606)3.83424406
54regulation of triglyceride catabolic process (GO:0010896)3.78244580
55nitrogen cycle metabolic process (GO:0071941)3.75466584
56aldehyde catabolic process (GO:0046185)3.74770777
57ketone body metabolic process (GO:1902224)3.70692962
58tyrosine metabolic process (GO:0006570)3.69320556
59protein carboxylation (GO:0018214)3.68169126
60peptidyl-glutamic acid carboxylation (GO:0017187)3.68169126
61triglyceride homeostasis (GO:0070328)3.66794105
62acylglycerol homeostasis (GO:0055090)3.66794105
63protein-lipid complex remodeling (GO:0034368)3.65903315
64macromolecular complex remodeling (GO:0034367)3.65903315
65plasma lipoprotein particle remodeling (GO:0034369)3.65903315
66regulation of complement activation (GO:0030449)3.65220845
67omega-hydroxylase P450 pathway (GO:0097267)3.62437277
68regulation of cholesterol esterification (GO:0010872)3.62136121
69fibrinolysis (GO:0042730)3.61823944
70cellular amino acid catabolic process (GO:0009063)3.60427156
71cellular glucuronidation (GO:0052695)3.59330726
72reverse cholesterol transport (GO:0043691)3.59304772
73cellular biogenic amine catabolic process (GO:0042402)3.59236154
74amine catabolic process (GO:0009310)3.59236154
75imidazole-containing compound metabolic process (GO:0052803)3.58661536
76gas transport (GO:0015669)3.53603096
77cofactor catabolic process (GO:0051187)3.52115962
78response to nitrosative stress (GO:0051409)3.52045320
79negative regulation of cholesterol transport (GO:0032375)3.50075432
80negative regulation of sterol transport (GO:0032372)3.50075432
81protein-lipid complex assembly (GO:0065005)3.49895802
82regulation of bile acid biosynthetic process (GO:0070857)3.44879605
83response to mercury ion (GO:0046689)3.44872196
84oxygen transport (GO:0015671)3.44593915
85low-density lipoprotein particle clearance (GO:0034383)3.42081491
86aspartate family amino acid catabolic process (GO:0009068)3.41574150
87phospholipid efflux (GO:0033700)3.41130063
88glutamate metabolic process (GO:0006536)3.39928565
89bile acid and bile salt transport (GO:0015721)3.39227141
90plasma lipoprotein particle clearance (GO:0034381)3.34622184
91regulation of plasminogen activation (GO:0010755)3.34036653
92benzene-containing compound metabolic process (GO:0042537)3.28584879
93drug catabolic process (GO:0042737)3.28431559
94plasma lipoprotein particle organization (GO:0071827)3.27827537
95cholesterol efflux (GO:0033344)3.27327899
96* tetrapyrrole metabolic process (GO:0033013)3.26647800
97folic acid metabolic process (GO:0046655)3.26482196
98arginine metabolic process (GO:0006525)3.25598696
99blood coagulation, intrinsic pathway (GO:0007597)3.22674328
100short-chain fatty acid metabolic process (GO:0046459)3.20461045
101indolalkylamine metabolic process (GO:0006586)3.20221444
102carboxylic acid catabolic process (GO:0046395)3.18613570
103organic acid catabolic process (GO:0016054)3.18613570
104uronic acid metabolic process (GO:0006063)3.18257158
105glucuronate metabolic process (GO:0019585)3.18257158
106branched-chain amino acid catabolic process (GO:0009083)3.16107525
107fatty acid beta-oxidation (GO:0006635)3.14128686
108acetyl-CoA metabolic process (GO:0006084)3.13824344
109urate metabolic process (GO:0046415)3.13522045
110protein activation cascade (GO:0072376)3.12364785
111negative regulation of fatty acid biosynthetic process (GO:0045717)3.12024632
112positive regulation of hemostasis (GO:1900048)3.11602926
113positive regulation of blood coagulation (GO:0030194)3.11602926
114drug transmembrane transport (GO:0006855)3.08793132
115fatty acid oxidation (GO:0019395)3.08763837
116positive regulation of triglyceride lipase activity (GO:0061365)3.07436412
117positive regulation of lipoprotein lipase activity (GO:0051006)3.07436412
118drug metabolic process (GO:0017144)3.03774996
119negative regulation of blood coagulation (GO:0030195)3.01112179
120negative regulation of hemostasis (GO:1900047)3.01112179
121positive regulation of triglyceride metabolic process (GO:0090208)3.00681995
122complement activation (GO:0006956)2.97661228
123complement activation, classical pathway (GO:0006958)2.95078300
124response to lead ion (GO:0010288)2.91255302
125protein-lipid complex subunit organization (GO:0071825)2.89081591
126positive regulation of coagulation (GO:0050820)2.84931972
127positive regulation of lipid catabolic process (GO:0050996)2.83420482
128acylglycerol catabolic process (GO:0046464)2.78032854
129neutral lipid catabolic process (GO:0046461)2.78032854
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77176869
131triglyceride catabolic process (GO:0019433)2.77055826
132erythrocyte development (GO:0048821)2.76799958
133regulation of apoptotic cell clearance (GO:2000425)2.74749423
134acute-phase response (GO:0006953)2.69673050
135regulation of cholesterol metabolic process (GO:0090181)2.69202802
136disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.68926920
137killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.68926920
138negative regulation of protein activation cascade (GO:2000258)2.67732713
139regulation of cholesterol biosynthetic process (GO:0045540)2.66221079
140negative regulation of coagulation (GO:0050819)2.65440145
141regulation of triglyceride metabolic process (GO:0090207)2.64922621
142positive regulation of fatty acid biosynthetic process (GO:0045723)2.63359820
143oxaloacetate metabolic process (GO:0006107)2.61013366
144regulation of cholesterol storage (GO:0010885)2.59232788
145negative regulation of lipid transport (GO:0032369)2.57141255
146regulation of cholesterol homeostasis (GO:2000188)2.56682343
147negative regulation of lipase activity (GO:0060192)2.56489895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.95146945
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.14487889
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.67070458
4* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64410428
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse4.31419236
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.27290141
7E2F7_22180533_ChIP-Seq_HELA_Human4.15638222
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.88016500
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.71557635
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25921968
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.89345749
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.30460107
13GATA1_22025678_ChIP-Seq_K562_Human2.25453434
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.24288245
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13976101
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11981488
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08185860
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.06696085
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92803466
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91097239
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.83850924
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83824710
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81801938
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71530234
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71447395
26AR_21909140_ChIP-Seq_LNCAP_Human1.67654567
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62618619
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.62196347
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61617018
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.61399204
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.59913553
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59552334
33KDM2B_26808549_Chip-Seq_K562_Human1.57253970
34GATA1_19941826_ChIP-Seq_K562_Human1.57208751
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.54882028
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54767002
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54551501
38XRN2_22483619_ChIP-Seq_HELA_Human1.52354590
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47747287
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.44780262
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42754429
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41978188
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40693971
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39633053
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.38966489
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38651146
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38442209
48* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36722480
49KDM2B_26808549_Chip-Seq_DND41_Human1.36064450
50TCF7_22412390_ChIP-Seq_EML_Mouse1.35946660
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34692477
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34616048
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34571048
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.34177790
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31991465
56ZNF263_19887448_ChIP-Seq_K562_Human1.30303156
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29557008
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28590412
59DROSHA_22980978_ChIP-Seq_HELA_Human1.27732671
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.26112794
61* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26108079
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25571481
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25470679
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25400544
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.24320667
66RACK7_27058665_Chip-Seq_MCF-7_Human1.23680553
67* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21572333
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21338219
69P68_20966046_ChIP-Seq_HELA_Human1.19887065
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19190404
71DCP1A_22483619_ChIP-Seq_HELA_Human1.18856286
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18654230
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18296599
74SMC4_20622854_ChIP-Seq_HELA_Human1.18125675
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17790026
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17691021
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17536521
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17322333
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.16606065
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16192656
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13944208
82CLOCK_20551151_ChIP-Seq_293T_Human1.13076971
83GABP_19822575_ChIP-Seq_HepG2_Human1.12870128
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12759138
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.12396158
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.12396158
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12229943
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12131941
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11301187
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.11026748
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10665902
92* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10477270
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10402974
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10049177
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09773341
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09068964
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08644003
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07148284
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.05641949
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05564905
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05270845
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04791395
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03961454
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03432404
105* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01919516
106* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01656817
107MYC_22102868_ChIP-Seq_BL_Human1.01352424
108KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01210746
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99030821
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98447361
111CREB1_26743006_Chip-Seq_LNCaP_Human0.98181376
112FOXP3_21729870_ChIP-Seq_TREG_Human0.96665949
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96580949
114CTCF_27219007_Chip-Seq_Bcells_Human0.96307503
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95816292
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95699687
117LXR_22292898_ChIP-Seq_THP-1_Human0.95338885
118BCL6_27268052_Chip-Seq_Bcells_Human0.95068565
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94682800
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.94477463
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.94377059
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93795515
123* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93750074
124VDR_24763502_ChIP-Seq_THP-1_Human0.93023427
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92802119
126* VDR_23849224_ChIP-Seq_CD4+_Human0.92628328
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92081559
128VDR_21846776_ChIP-Seq_THP-1_Human0.91920219
129MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91409776
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.91322962
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91292515
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91292049
133* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89528847
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89205472
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89085995
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.88857481
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87657216
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87634314
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87370136
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86164426
141* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85977551
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85807312
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85605723
144JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85341477
145SCL_19346495_ChIP-Seq_HPC-7_Human0.85222640
146YY1_22570637_ChIP-Seq_MALME-3M_Human0.85209427
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84459360
148ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84310312
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84028985
150TET1_21451524_ChIP-Seq_MESCs_Mouse0.83818019
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83048255
152E2F1_21310950_ChIP-Seq_MCF-7_Human0.82802388
153GATA2_19941826_ChIP-Seq_K562_Human0.82712851
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81335399
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80611508
156CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80528820
157PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80225823
158* HNF4A_19822575_ChIP-Seq_HepG2_Human0.79734704
159BCOR_27268052_Chip-Seq_Bcells_Human0.79173082
160SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78998718
161KDM5A_27292631_Chip-Seq_BREAST_Human0.77687297
162CTCF_21964334_Chip-Seq_Bcells_Human0.77185229
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75529555
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75495032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.93287823
2MP0005360_urolithiasis6.27875070
3MP0005085_abnormal_gallbladder_physiolo5.32662675
4MP0003806_abnormal_nucleotide_metabolis4.98373150
5MP0003656_abnormal_erythrocyte_physiolo4.87080509
6MP0005365_abnormal_bile_salt4.80226181
7MP0004147_increased_porphyrin_level4.35497920
8MP0008875_abnormal_xenobiotic_pharmacok4.05097825
9MP0005083_abnormal_biliary_tract3.32282113
10MP0010329_abnormal_lipoprotein_level2.96585802
11MP0009840_abnormal_foam_cell2.83831905
12MP0003252_abnormal_bile_duct2.66573137
13MP0005332_abnormal_amino_acid2.63167136
14MP0001666_abnormal_nutrient_absorption2.32148709
15MP0003195_calcinosis2.31996127
16MP0003329_amyloid_beta_deposits2.10988932
17MP0005058_abnormal_lysosome_morphology2.09860491
18MP0000609_abnormal_liver_physiology2.04327651
19MP0003690_abnormal_glial_cell2.01505738
20MP0003172_abnormal_lysosome_physiology1.95894489
21MP0003186_abnormal_redox_activity1.95729823
22MP0006036_abnormal_mitochondrial_physio1.92620871
23MP0003191_abnormal_cellular_cholesterol1.89208808
24MP0005319_abnormal_enzyme/_coenzyme1.86530550
25MP0004019_abnormal_vitamin_homeostasis1.83613126
26MP0003879_abnormal_hair_cell1.83252627
27MP0005636_abnormal_mineral_homeostasis1.81807850
28MP0008004_abnormal_stomach_pH1.71997370
29MP0003693_abnormal_embryo_hatching1.71085759
30MP0002118_abnormal_lipid_homeostasis1.70080313
31MP0002876_abnormal_thyroid_physiology1.70007364
32MP0000604_amyloidosis1.67074780
33MP0000566_synostosis1.67039973
34MP0001764_abnormal_homeostasis1.65205266
35MP0004859_abnormal_synaptic_plasticity1.58311773
36MP0009643_abnormal_urine_homeostasis1.57600198
37MP0005584_abnormal_enzyme/coenzyme_acti1.54599435
38MP0008260_abnormal_autophagy1.53753627
39MP0009379_abnormal_foot_pigmentation1.43566125
40MP0002138_abnormal_hepatobiliary_system1.32018487
41MP0005451_abnormal_body_composition1.29661424
42MP0000598_abnormal_liver_morphology1.25696019
43MP0009780_abnormal_chondrocyte_physiolo1.23728918
44MP0005670_abnormal_white_adipose1.21000586
45MP0000920_abnormal_myelination1.16009801
46MP0003111_abnormal_nucleus_morphology1.13108409
47MP0005375_adipose_tissue_phenotype1.12713243
48MP0003075_altered_response_to1.10236950
49MP0003011_delayed_dark_adaptation1.09224283
50MP0005266_abnormal_metabolism1.09177791
51MP0003868_abnormal_feces_composition1.07065274
52MP0003303_peritoneal_inflammation1.06761262
53MP0009697_abnormal_copulation1.06343476
54MP0005408_hypopigmentation1.04840246
55MP0001756_abnormal_urination1.04742581
56MP0008874_decreased_physiological_sensi1.02008069
57MP0003300_gastrointestinal_ulcer1.00359667
58MP0005376_homeostasis/metabolism_phenot0.97112800
59MP0005334_abnormal_fat_pad0.96919785
60MP0009763_increased_sensitivity_to0.96391827
61MP0010368_abnormal_lymphatic_system0.94852355
62MP0004957_abnormal_blastocyst_morpholog0.94384652
63MP0003705_abnormal_hypodermis_morpholog0.94073552
64MP0002837_dystrophic_cardiac_calcinosis0.93245308
65MP0000751_myopathy0.88988715
66MP0009642_abnormal_blood_homeostasis0.85419973
67MP0003718_maternal_effect0.83072085
68MP0002132_abnormal_respiratory_system0.83030512
69MP0003279_aneurysm0.82473469
70MP0001851_eye_inflammation0.81733947
71MP0005647_abnormal_sex_gland0.81668915
72MP0008469_abnormal_protein_level0.78697546
73MP0002970_abnormal_white_adipose0.77570114
74MP0004185_abnormal_adipocyte_glucose0.76751539
75MP0005167_abnormal_blood-brain_barrier0.75160351
76MP0008872_abnormal_physiological_respon0.74088766
77MP0002064_seizures0.73310903
78MP0005409_darkened_coat_color0.72737116
79MP0009764_decreased_sensitivity_to0.72684897
80MP0009765_abnormal_xenobiotic_induced0.72196289
81MP0003077_abnormal_cell_cycle0.71057406
82MP0008438_abnormal_cutaneous_collagen0.70803262
83MP0006138_congestive_heart_failure0.70768384
84MP0002909_abnormal_adrenal_gland0.70649433
85MP0002078_abnormal_glucose_homeostasis0.70607887
86MP0006035_abnormal_mitochondrial_morpho0.70427813
87MP0003724_increased_susceptibility_to0.69196948
88MP0000639_abnormal_adrenal_gland0.68740788
89MP0001501_abnormal_sleep_pattern0.67825460
90MP0004043_abnormal_pH_regulation0.66836645
91MP0001545_abnormal_hematopoietic_system0.66773711
92MP0005397_hematopoietic_system_phenotyp0.66773711
93MP0008569_lethality_at_weaning0.66280325
94MP0005220_abnormal_exocrine_pancreas0.66090604
95MP0000490_abnormal_crypts_of0.66021896
96MP0000003_abnormal_adipose_tissue0.65172219
97MP0000249_abnormal_blood_vessel0.64744476
98MP0010094_abnormal_chromosome_stability0.64426456
99MP0002971_abnormal_brown_adipose0.63578192
100MP0003566_abnormal_cell_adhesion0.63539176
101MP0009278_abnormal_bone_marrow0.61967962
102MP0000747_muscle_weakness0.61536164
103MP0009115_abnormal_fat_cell0.61308167
104MP0002396_abnormal_hematopoietic_system0.60916519
105MP0005330_cardiomyopathy0.60700291
106MP0003635_abnormal_synaptic_transmissio0.59139848
107MP0009053_abnormal_anal_canal0.58820138
108MP0003436_decreased_susceptibility_to0.58439190
109MP0003633_abnormal_nervous_system0.58344070
110MP0005423_abnormal_somatic_nervous0.57702261
111MP0002136_abnormal_kidney_physiology0.57699378
112MP0005166_decreased_susceptibility_to0.57450263
113MP0005164_abnormal_response_to0.56445918
114MP0003631_nervous_system_phenotype0.56443798
115MP0003632_abnormal_nervous_system0.55407866
116MP0003045_fibrosis0.55181175
117MP0003646_muscle_fatigue0.54982694
118MP0005084_abnormal_gallbladder_morpholo0.54782369
119MP0001958_emphysema0.54020665
120MP0005666_abnormal_adipose_tissue0.53387344
121MP0002249_abnormal_larynx_morphology0.52251284
122MP0004130_abnormal_muscle_cell0.52157742
123MP0005448_abnormal_energy_balance0.49697094
124MP0004264_abnormal_extraembryonic_tissu0.49363323
125MP0008873_increased_physiological_sensi0.46606776
126MP0009672_abnormal_birth_weight0.46436999
127MP0005464_abnormal_platelet_physiology0.45228212
128MP0008775_abnormal_heart_ventricle0.45074721
129MP0001661_extended_life_span0.44727079
130MP0005501_abnormal_skin_physiology0.41440315
131MP0005535_abnormal_body_temperature0.41064740
132MP0001663_abnormal_digestive_system0.40786568
133MP0009931_abnormal_skin_appearance0.39223672
134MP0008057_abnormal_DNA_replication0.39197624
135MP0003953_abnormal_hormone_level0.37735787
136MP0000749_muscle_degeneration0.37433953
137MP0001730_embryonic_growth_arrest0.37394235
138MP0002135_abnormal_kidney_morphology0.35893964
139MP0000230_abnormal_systemic_arterial0.34878011
140MP0004782_abnormal_surfactant_physiolog0.34105217
141MP0004215_abnormal_myocardial_fiber0.33884140
142MP0002332_abnormal_exercise_endurance0.33570400
143MP0000689_abnormal_spleen_morphology0.32543581
144MP0002269_muscular_atrophy0.32127266
145MP0001243_abnormal_dermal_layer0.32071842
146MP0005395_other_phenotype0.31226714

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of the heme biosynthetic pathway (HP:0010472)7.38590890
2Poikilocytosis (HP:0004447)5.30888506
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.25299167
4Deep venous thrombosis (HP:0002625)5.11742920
5Intrahepatic cholestasis (HP:0001406)5.04031870
6Systemic lupus erythematosus (HP:0002725)4.95774835
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.91434425
8Hypobetalipoproteinemia (HP:0003563)4.76252517
9Xanthomatosis (HP:0000991)4.53500205
10Hyperbilirubinemia (HP:0002904)4.52605514
11Acanthocytosis (HP:0001927)4.46388651
12Reticulocytosis (HP:0001923)4.44036328
13Prolonged partial thromboplastin time (HP:0003645)4.36561095
14Hypochromic microcytic anemia (HP:0004840)4.27370380
15Hyperlipoproteinemia (HP:0010980)4.03078996
16Cholelithiasis (HP:0001081)4.00865883
17Hypercholesterolemia (HP:0003124)3.97506309
18Hyperammonemia (HP:0001987)3.88221343
19Abnormal gallbladder morphology (HP:0012437)3.78703752
20Hypolipoproteinemia (HP:0010981)3.77432055
21Hepatocellular carcinoma (HP:0001402)3.62366853
22Ketosis (HP:0001946)3.59603113
23Glomerulonephritis (HP:0000099)3.47950172
24Complement deficiency (HP:0004431)3.47392924
25Hypoglycemic coma (HP:0001325)3.45545374
26Hypoalphalipoproteinemia (HP:0003233)3.41229679
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.40801651
28Hyperglycinuria (HP:0003108)3.38115283
29Brushfield spots (HP:0001088)3.32147005
30Abnormality of reticulocytes (HP:0004312)3.30580811
31Polycythemia (HP:0001901)3.30151382
32Hyperglycinemia (HP:0002154)3.29023453
33Abnormality of glycine metabolism (HP:0010895)3.25293060
34Abnormality of serine family amino acid metabolism (HP:0010894)3.25293060
35Abnormality of pyrimidine metabolism (HP:0004353)3.24526539
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.24089955
37Abnormality of fatty-acid metabolism (HP:0004359)3.16866385
38Joint hemorrhage (HP:0005261)3.07407356
39Nausea (HP:0002018)3.03812651
40Ileus (HP:0002595)2.99507801
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95863068
42Abnormality of the gallbladder (HP:0005264)2.95182355
43Abnormal gallbladder physiology (HP:0012438)2.95102773
44Cholecystitis (HP:0001082)2.95102773
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93947950
46Cerebral edema (HP:0002181)2.93625333
47Diaphragmatic weakness (HP:0009113)2.88246382
48Hepatic necrosis (HP:0002605)2.87404255
49Abnormality of methionine metabolism (HP:0010901)2.86903738
50Fat malabsorption (HP:0002630)2.83822061
51Hemorrhage of the eye (HP:0011885)2.83550317
52Abnormal number of erythroid precursors (HP:0012131)2.81783447
53Increased serum ferritin (HP:0003281)2.79850904
54Hypertriglyceridemia (HP:0002155)2.79422525
55Metabolic acidosis (HP:0001942)2.78884339
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78738970
57Abnormality of the common coagulation pathway (HP:0010990)2.75224845
58Abnormality of iron homeostasis (HP:0011031)2.75003988
59Ketoacidosis (HP:0001993)2.74311164
60Osteomalacia (HP:0002749)2.70758289
61Abnormality of transition element cation homeostasis (HP:0011030)2.67849366
62Abnormal hemoglobin (HP:0011902)2.66952502
63Recurrent gram-negative bacterial infections (HP:0005420)2.66614341
64Delayed CNS myelination (HP:0002188)2.66052971
65Epidermoid cyst (HP:0200040)2.65759088
66Abnormality of nucleobase metabolism (HP:0010932)2.65561219
67Lethargy (HP:0001254)2.65513692
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64271234
69Dicarboxylic aciduria (HP:0003215)2.64271234
70Mitral stenosis (HP:0001718)2.62791890
71Abnormality of complement system (HP:0005339)2.51896228
72Abnormality of cells of the erythroid lineage (HP:0012130)2.49725923
73Abnormality of the intrinsic pathway (HP:0010989)2.47531405
74Gout (HP:0001997)2.44665179
75Abnormality of the lower motor neuron (HP:0002366)2.44185443
76Generalized aminoaciduria (HP:0002909)2.43895850
77Prolonged bleeding time (HP:0003010)2.42902624
78Hepatocellular necrosis (HP:0001404)2.42067495
79Nephritis (HP:0000123)2.40437665
80Gingival bleeding (HP:0000225)2.39597774
81Abnormality of purine metabolism (HP:0004352)2.36078559
82Purpura (HP:0000979)2.35433773
83Abnormality of serum amino acid levels (HP:0003112)2.34860708
84* Vomiting (HP:0002013)2.33568184
85Morphological abnormality of the middle ear (HP:0008609)2.31778982
86Abnormality of polysaccharide metabolism (HP:0011012)2.29899932
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29899932
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29899932
89Acute encephalopathy (HP:0006846)2.28471313
90Microcytic anemia (HP:0001935)2.28435004
91Urinary glycosaminoglycan excretion (HP:0003541)2.27016135
92Mucopolysacchariduria (HP:0008155)2.27016135
93Menorrhagia (HP:0000132)2.20830593
94Hypochromic anemia (HP:0001931)2.17635140
95* Paralysis (HP:0003470)2.15988217
96Cerebral inclusion bodies (HP:0100314)2.12150818
97Neurofibrillary tangles (HP:0002185)2.12097501
98Steatorrhea (HP:0002570)2.12050769
99Secondary amenorrhea (HP:0000869)2.08376075
100Abnormality of urine glucose concentration (HP:0011016)2.08077008
101Glycosuria (HP:0003076)2.08077008
102Epistaxis (HP:0000421)2.07067868
103* Cerebral palsy (HP:0100021)2.06082386
104Spastic diplegia (HP:0001264)2.05851773
105Insomnia (HP:0100785)2.01431826
106Increased mean platelet volume (HP:0011877)2.00818246
107Rickets (HP:0002748)1.99595894
108Amyloidosis (HP:0011034)1.98828617
109Abnormal platelet volume (HP:0011876)1.95820460
110Dysostosis multiplex (HP:0000943)1.95243318
111Proximal tubulopathy (HP:0000114)1.92748350
112Conjugated hyperbilirubinemia (HP:0002908)1.91158160
113Nonimmune hydrops fetalis (HP:0001790)1.89304745
114Spontaneous abortion (HP:0005268)1.88496990
115Increased purine levels (HP:0004368)1.87980989
116Hyperuricemia (HP:0002149)1.87980989
117Skin nodule (HP:0200036)1.86616673
118Abnormal platelet function (HP:0011869)1.86505715
119Impaired platelet aggregation (HP:0003540)1.86505715
120Abnormal mitochondria in muscle tissue (HP:0008316)1.85800008
121Abnormal cartilage morphology (HP:0002763)1.84588782
122Thrombophlebitis (HP:0004418)1.84436831
123Tetraplegia (HP:0002445)1.84065023
124Hypercortisolism (HP:0001578)1.83041651
125Ventricular fibrillation (HP:0001663)1.82975840
126Lactic acidosis (HP:0003128)1.81870838
127Protrusio acetabuli (HP:0003179)1.81508420
128Myocardial infarction (HP:0001658)1.79218631
129Atrioventricular block (HP:0001678)1.79072474
130Opisthotonus (HP:0002179)1.78985371
131Acute necrotizing encephalopathy (HP:0006965)1.78931385
132Ankle clonus (HP:0011448)1.78234806
133Increased muscle lipid content (HP:0009058)1.78132987
134Neonatal onset (HP:0003623)1.78068529
135Diplopia (HP:0000651)1.76685207
136Abnormality of binocular vision (HP:0011514)1.76685207
137Rhabdomyolysis (HP:0003201)1.76505770
138Back pain (HP:0003418)1.74867099
139Growth hormone excess (HP:0000845)1.73274938
140Acanthosis nigricans (HP:0000956)1.70851431
141Toxemia of pregnancy (HP:0100603)1.69058064
142Vertebral compression fractures (HP:0002953)1.67010846
143Asymmetric septal hypertrophy (HP:0001670)1.66841528
144Obstructive sleep apnea (HP:0002870)1.66416098
145Supranuclear gaze palsy (HP:0000605)1.66405898
146Distal lower limb muscle weakness (HP:0009053)1.62573729
147Abnormality of the periventricular white matter (HP:0002518)1.61865735
148Cerebral aneurysm (HP:0004944)1.60822876
149Peripheral hypomyelination (HP:0007182)1.59678179
150Muscle fiber splitting (HP:0003555)1.54535725
151Abnormal atrioventricular conduction (HP:0005150)1.53860920
152Depression (HP:0000716)1.53735296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.00412125
2PRPF4B5.60417936
3BUB13.64788845
4EIF2AK13.35197058
5KDR2.80935304
6RIPK12.54009922
7NME22.48168445
8MAP3K102.30348260
9PKN22.27551247
10ERN12.23977614
11STK162.16140843
12NEK12.05371727
13CDC72.00805395
14TTK1.98329094
15MAP3K21.96931739
16FLT31.78361483
17LRRK21.74247095
18NTRK31.64743000
19SRPK11.64569972
20SIK11.64444242
21AURKA1.63046591
22ABL21.57796260
23MAP3K111.53195154
24TLK11.52697263
25BRSK11.48348815
26TRIB31.46076962
27MAPK111.45224978
28CHEK21.38865959
29PBK1.37487916
30PRKD31.36504305
31DYRK31.36387106
32PDPK11.36307423
33MAP3K11.35881444
34BRSK21.34664376
35KSR21.33900321
36MAP2K71.33866820
37PLK11.30458734
38WEE11.30172814
39TNK21.28847833
40TAOK31.26984064
41ICK1.26092986
42PIM11.25397458
43AURKB1.23282122
44TESK11.23144286
45PAK61.22920617
46MARK21.22132483
47EPHA41.17962517
48FGFR41.17172778
49MAP2K31.15204285
50RIPK41.14845358
51NME11.13237206
52JAK11.12233879
53DYRK1B1.08300515
54MAP2K41.08234322
55PDK11.04828615
56STK381.04519755
57TAOK11.02798073
58EPHB11.02079068
59MAP3K60.99318731
60RET0.98147535
61ARAF0.97171750
62MAP2K10.96159129
63MAP3K30.94758319
64KIT0.93190586
65PIK3CG0.93092200
66PLK30.92642083
67DMPK0.90907979
68LMTK20.90848124
69SGK30.90812569
70ERBB40.89917727
71DAPK20.88791973
72NEK20.88406689
73STK40.87163935
74MAP3K50.87035919
75TYK20.86829370
76UHMK10.86143063
77MAP2K20.83984993
78MARK10.83532488
79SIK20.83171758
80SGK20.81893547
81FGFR30.80566776
82CAMKK10.79727308
83MAPK70.79482593
84RPS6KB20.79378672
85CDK40.79098132
86HIPK20.77218801
87MAP3K70.77132552
88ZAP700.75709975
89RPS6KA20.74953324
90MST1R0.74308918
91NTRK10.74259205
92JAK30.73794499
93PIM20.72734184
94PDGFRA0.70576473
95DDR20.70276834
96PRKD10.69701598
97STK100.69107263
98WNK10.68646154
99TGFBR10.68378771
100CAMK40.68121025
101CDC42BPA0.68099397
102RAF10.67836527
103CDK50.67679100
104GRK50.67548690
105GRK60.64891732
106MYLK0.62519863
107CAMK10.62385949
108FES0.61015142
109MAP3K80.59363993
110SGK4940.58370746
111SGK2230.58370746
112JAK20.58034828
113RPS6KL10.57197284
114RPS6KC10.57197284
115BMX0.57057017
116PIK3CA0.56681040
117PRKD20.56280807
118STK110.55348192
119SMG10.55314081
120MAPKAPK30.55245657
121LATS20.54944410
122SCYL20.54766446
123MINK10.54067840
124ATR0.53023117
125NEK90.52507371
126EPHA20.51966578
127MAPK30.51812143
128MAP3K130.51736919
129EEF2K0.51047343
130TTN0.50713278
131CSNK2A10.49791241
132SGK10.49791232
133TIE10.49767903
134EIF2AK30.49647485
135IRAK30.45552031
136TRPM70.45472452
137TBK10.45021662
138PRKAA10.43296414
139DAPK30.42648038
140TGFBR20.42203179
141PRKACG0.41999486
142MAP3K40.41889891
143MAPK120.41363451
144CDK80.40889558
145CSNK2A20.40357171
146CDK70.39909684
147CLK10.39337136
148MAPK40.38896048
149RPS6KA10.38289856
150TAOK20.38233201
151PRKAA20.37467766
152ATM0.36444798
153PTK60.36207576
154PRKCZ0.35798927
155CSF1R0.35347635
156TESK20.35040262
157ILK0.34917083
158WNK40.34636918
159PDK40.34470250
160PDK30.34470250
161MTOR0.33527399
162VRK10.33242795

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.50826482
2* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.11239764
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99507061
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78653511
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61307160
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54883203
7Fatty acid degradation_Homo sapiens_hsa000712.49610138
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37588747
9Tryptophan metabolism_Homo sapiens_hsa003802.31859032
10Arginine biosynthesis_Homo sapiens_hsa002202.26140650
11Nitrogen metabolism_Homo sapiens_hsa009102.24204791
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20156564
13Butanoate metabolism_Homo sapiens_hsa006502.19122977
14Propanoate metabolism_Homo sapiens_hsa006402.13475841
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06099003
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00232512
17Complement and coagulation cascades_Homo sapiens_hsa046101.97483396
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.97053556
19Peroxisome_Homo sapiens_hsa041461.95713203
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87232025
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85159773
22Chemical carcinogenesis_Homo sapiens_hsa052041.82138895
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77606858
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77199819
25beta-Alanine metabolism_Homo sapiens_hsa004101.75770565
26Pyruvate metabolism_Homo sapiens_hsa006201.73418799
27Fatty acid metabolism_Homo sapiens_hsa012121.72102222
28Vitamin B6 metabolism_Homo sapiens_hsa007501.70813085
29Selenocompound metabolism_Homo sapiens_hsa004501.68047084
30PPAR signaling pathway_Homo sapiens_hsa033201.57594030
31Carbon metabolism_Homo sapiens_hsa012001.56669332
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.51609483
33One carbon pool by folate_Homo sapiens_hsa006701.45262938
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43084583
35Sulfur relay system_Homo sapiens_hsa041221.41838404
36Biosynthesis of amino acids_Homo sapiens_hsa012301.39974689
37Retinol metabolism_Homo sapiens_hsa008301.38926823
38Histidine metabolism_Homo sapiens_hsa003401.38315092
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.37604833
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35271403
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35166449
42Folate biosynthesis_Homo sapiens_hsa007901.32653662
43Caffeine metabolism_Homo sapiens_hsa002321.32558270
44Sulfur metabolism_Homo sapiens_hsa009201.32051137
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.28663568
46Phenylalanine metabolism_Homo sapiens_hsa003601.27986031
47Tyrosine metabolism_Homo sapiens_hsa003501.22556241
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.22537434
49Prion diseases_Homo sapiens_hsa050201.21260311
50Fatty acid elongation_Homo sapiens_hsa000621.20656646
51Glutathione metabolism_Homo sapiens_hsa004801.19452635
52DNA replication_Homo sapiens_hsa030301.14091915
53Fat digestion and absorption_Homo sapiens_hsa049751.13295617
54Ribosome_Homo sapiens_hsa030101.12805087
55Bile secretion_Homo sapiens_hsa049761.10756688
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10623236
57Starch and sucrose metabolism_Homo sapiens_hsa005001.09922008
58ABC transporters_Homo sapiens_hsa020101.06978576
59Pentose phosphate pathway_Homo sapiens_hsa000301.01807092
60Arginine and proline metabolism_Homo sapiens_hsa003301.01461886
61Proteasome_Homo sapiens_hsa030501.00081120
62Staphylococcus aureus infection_Homo sapiens_hsa051500.98844573
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93754511
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91158365
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90983803
66Oxidative phosphorylation_Homo sapiens_hsa001900.88338728
67Parkinsons disease_Homo sapiens_hsa050120.85883199
68Other glycan degradation_Homo sapiens_hsa005110.83081955
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.80289288
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79677224
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78392121
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73868884
73Vitamin digestion and absorption_Homo sapiens_hsa049770.71719593
74Lysine degradation_Homo sapiens_hsa003100.70713022
75Synaptic vesicle cycle_Homo sapiens_hsa047210.68627110
76* Metabolic pathways_Homo sapiens_hsa011000.66638097
77Pyrimidine metabolism_Homo sapiens_hsa002400.64553606
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60265281
79Ovarian steroidogenesis_Homo sapiens_hsa049130.58890927
80Steroid biosynthesis_Homo sapiens_hsa001000.57760356
81Long-term potentiation_Homo sapiens_hsa047200.55651882
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.54922364
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54411220
84Mismatch repair_Homo sapiens_hsa034300.53395814
85Systemic lupus erythematosus_Homo sapiens_hsa053220.51885349
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51795023
87Insulin signaling pathway_Homo sapiens_hsa049100.49572948
88Huntingtons disease_Homo sapiens_hsa050160.49188695
89Glycerolipid metabolism_Homo sapiens_hsa005610.45946691
90Alzheimers disease_Homo sapiens_hsa050100.45889882
91Fructose and mannose metabolism_Homo sapiens_hsa000510.45307727
92Galactose metabolism_Homo sapiens_hsa000520.43439745
93Glucagon signaling pathway_Homo sapiens_hsa049220.42946473
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42234795
95Malaria_Homo sapiens_hsa051440.39327317
96Collecting duct acid secretion_Homo sapiens_hsa049660.35827465
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35813929
98Lysosome_Homo sapiens_hsa041420.35461272
99GnRH signaling pathway_Homo sapiens_hsa049120.33982303
100Pertussis_Homo sapiens_hsa051330.33583981
101Insulin secretion_Homo sapiens_hsa049110.32867586
102Gastric acid secretion_Homo sapiens_hsa049710.32179870
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31254319
104Linoleic acid metabolism_Homo sapiens_hsa005910.29898230
105Renin secretion_Homo sapiens_hsa049240.29705891
106Type II diabetes mellitus_Homo sapiens_hsa049300.29338077
107Spliceosome_Homo sapiens_hsa030400.29329686
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28998811
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.28744350
110GABAergic synapse_Homo sapiens_hsa047270.26714785
111Inositol phosphate metabolism_Homo sapiens_hsa005620.26655304
112Amoebiasis_Homo sapiens_hsa051460.26325609
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24885833
114Acute myeloid leukemia_Homo sapiens_hsa052210.24630507
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24539194
116Pancreatic secretion_Homo sapiens_hsa049720.23978849
117Cell cycle_Homo sapiens_hsa041100.23697162
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23598144
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20941252
120Homologous recombination_Homo sapiens_hsa034400.19991134
121Base excision repair_Homo sapiens_hsa034100.19618818
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17115808
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.17076137
124Arachidonic acid metabolism_Homo sapiens_hsa005900.16778233
125RNA transport_Homo sapiens_hsa030130.15136904
126Fatty acid biosynthesis_Homo sapiens_hsa000610.11506541
127Purine metabolism_Homo sapiens_hsa002300.11506068
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11257511
129Bladder cancer_Homo sapiens_hsa052190.07375931
130RNA polymerase_Homo sapiens_hsa030200.05744153
131Nucleotide excision repair_Homo sapiens_hsa034200.05558493
132Insulin resistance_Homo sapiens_hsa049310.04120289
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.02719935
134AMPK signaling pathway_Homo sapiens_hsa041520.02088919

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