ALAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.52944949
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.52944949
3L-phenylalanine metabolic process (GO:0006558)5.30751680
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.30751680
5aromatic amino acid family catabolic process (GO:0009074)5.13261006
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.10002671
7alpha-linolenic acid metabolic process (GO:0036109)4.98351585
8tryptophan catabolic process (GO:0006569)4.76855730
9indole-containing compound catabolic process (GO:0042436)4.76855730
10indolalkylamine catabolic process (GO:0046218)4.76855730
11kynurenine metabolic process (GO:0070189)4.71846830
12killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.71298462
13disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.71298462
14bile acid biosynthetic process (GO:0006699)4.65575716
15urea cycle (GO:0000050)4.61005895
16urea metabolic process (GO:0019627)4.61005895
17glyoxylate metabolic process (GO:0046487)4.59414409
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57809061
19protein carboxylation (GO:0018214)4.55608550
20peptidyl-glutamic acid carboxylation (GO:0017187)4.55608550
21tryptophan metabolic process (GO:0006568)4.46964947
22glycosphingolipid catabolic process (GO:0046479)4.44145809
23regulation of triglyceride catabolic process (GO:0010896)4.43417649
24sulfur amino acid catabolic process (GO:0000098)4.41416060
25complement activation, alternative pathway (GO:0006957)4.41367306
26high-density lipoprotein particle remodeling (GO:0034375)4.35100651
27protein-lipid complex remodeling (GO:0034368)4.25164704
28macromolecular complex remodeling (GO:0034367)4.25164704
29plasma lipoprotein particle remodeling (GO:0034369)4.25164704
30nitrogen cycle metabolic process (GO:0071941)4.24223047
31lysine metabolic process (GO:0006553)4.22941233
32lysine catabolic process (GO:0006554)4.22941233
33amino-acid betaine metabolic process (GO:0006577)4.21958038
34plasma lipoprotein particle clearance (GO:0034381)4.19355884
35negative regulation of fibrinolysis (GO:0051918)4.03939514
36cysteine metabolic process (GO:0006534)4.03651530
37regulation of protein activation cascade (GO:2000257)4.03595961
38glycolipid catabolic process (GO:0019377)4.03447172
39killing of cells of other organism (GO:0031640)4.02417353
40disruption of cells of other organism (GO:0044364)4.02417353
41low-density lipoprotein particle remodeling (GO:0034374)3.93390936
42aldehyde catabolic process (GO:0046185)3.90978280
43bile acid metabolic process (GO:0008206)3.90933594
44homocysteine metabolic process (GO:0050667)3.87246411
45regulation of fibrinolysis (GO:0051917)3.83391098
46regulation of cholesterol esterification (GO:0010872)3.81168794
47regulation of complement activation (GO:0030449)3.80740366
48reverse cholesterol transport (GO:0043691)3.80666246
49benzene-containing compound metabolic process (GO:0042537)3.76197278
50xenobiotic catabolic process (GO:0042178)3.75040326
51positive regulation of lipid catabolic process (GO:0050996)3.73962454
52phospholipid efflux (GO:0033700)3.72485504
53glucocorticoid biosynthetic process (GO:0006704)3.71077799
54triglyceride homeostasis (GO:0070328)3.67067280
55acylglycerol homeostasis (GO:0055090)3.67067280
56serine family amino acid catabolic process (GO:0009071)3.65839179
57aromatic amino acid family metabolic process (GO:0009072)3.64611336
58epoxygenase P450 pathway (GO:0019373)3.62565940
59cellular glucuronidation (GO:0052695)3.60956440
60alpha-amino acid catabolic process (GO:1901606)3.60658863
61reactive oxygen species biosynthetic process (GO:1903409)3.59573387
62low-density lipoprotein particle clearance (GO:0034383)3.59131161
63carnitine metabolic process (GO:0009437)3.57323004
64fatty acid beta-oxidation (GO:0006635)3.56947444
65NADH metabolic process (GO:0006734)3.56199349
662-oxoglutarate metabolic process (GO:0006103)3.54742502
67oligosaccharide catabolic process (GO:0009313)3.53876399
68ceramide catabolic process (GO:0046514)3.53169977
69tyrosine metabolic process (GO:0006570)3.51716927
70uronic acid metabolic process (GO:0006063)3.51396446
71glucuronate metabolic process (GO:0019585)3.51396446
72valine metabolic process (GO:0006573)3.51200123
73regulation of macrophage chemotaxis (GO:0010758)3.48555953
74cholesterol efflux (GO:0033344)3.47682077
75phospholipid homeostasis (GO:0055091)3.47662062
76ethanol oxidation (GO:0006069)3.47446028
77fatty acid oxidation (GO:0019395)3.46694942
78negative regulation of sterol transport (GO:0032372)3.44383184
79negative regulation of cholesterol transport (GO:0032375)3.44383184
80drug catabolic process (GO:0042737)3.43380764
81lipid oxidation (GO:0034440)3.42251551
82cellular ketone body metabolic process (GO:0046950)3.41264055
83acetyl-CoA metabolic process (GO:0006084)3.38058036
84plasma lipoprotein particle organization (GO:0071827)3.37509257
85acute-phase response (GO:0006953)3.37380064
86fat-soluble vitamin biosynthetic process (GO:0042362)3.36710643
87omega-hydroxylase P450 pathway (GO:0097267)3.34899445
88imidazole-containing compound metabolic process (GO:0052803)3.34667235
89cellular amino acid catabolic process (GO:0009063)3.33907817
90cofactor catabolic process (GO:0051187)3.32874826
91regulation of cholesterol storage (GO:0010885)3.32112621
92short-chain fatty acid metabolic process (GO:0046459)3.29336508
93fatty acid catabolic process (GO:0009062)3.28913802
94monocarboxylic acid catabolic process (GO:0072329)3.28493410
95regulation of mononuclear cell migration (GO:0071675)3.27802742
96plasma lipoprotein particle assembly (GO:0034377)3.27320266
97positive regulation of fatty acid beta-oxidation (GO:0032000)3.26575494
98amine catabolic process (GO:0009310)3.26547080
99cellular biogenic amine catabolic process (GO:0042402)3.26547080
100positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.26211446
101positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25419854
102indolalkylamine metabolic process (GO:0006586)3.25331729
103positive regulation of lipoprotein lipase activity (GO:0051006)3.23826544
104positive regulation of triglyceride lipase activity (GO:0061365)3.23826544
105Golgi transport vesicle coating (GO:0048200)3.23428485
106COPI coating of Golgi vesicle (GO:0048205)3.23428485
107response to nitrosative stress (GO:0051409)3.22921068
108cholesterol homeostasis (GO:0042632)3.21855855
109coenzyme catabolic process (GO:0009109)3.20577218
110hydrogen peroxide biosynthetic process (GO:0050665)3.19696129
111fibrinolysis (GO:0042730)3.19498603
112organic acid catabolic process (GO:0016054)3.19386105
113carboxylic acid catabolic process (GO:0046395)3.19386105
114nicotinamide nucleotide biosynthetic process (GO:0019359)3.18706237
115pyridine nucleotide biosynthetic process (GO:0019363)3.18706237
116dicarboxylic acid biosynthetic process (GO:0043650)3.18218908
117sterol homeostasis (GO:0055092)3.17470939
118oxaloacetate metabolic process (GO:0006107)3.16738963
119very-low-density lipoprotein particle assembly (GO:0034379)3.12817862
120detection of molecule of bacterial origin (GO:0032490)3.09824016
121cellular response to cadmium ion (GO:0071276)3.09270540
122C21-steroid hormone biosynthetic process (GO:0006700)3.06614622
123eosinophil chemotaxis (GO:0048245)2.99456488
124response to thyroid hormone (GO:0097066)2.97003911
125regulation of vitamin D biosynthetic process (GO:0060556)2.93778564
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.93413475
127complement activation (GO:0006956)2.92417305
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90341385
129cellular response to thyroid hormone stimulus (GO:0097067)2.89172979
130glucocorticoid metabolic process (GO:0008211)2.88034278
131progesterone metabolic process (GO:0042448)2.87392898
132complement activation, classical pathway (GO:0006958)2.86811518
133positive regulation of fatty acid biosynthetic process (GO:0045723)2.85687102
134tricarboxylic acid cycle (GO:0006099)2.83312816
135sphingolipid catabolic process (GO:0030149)2.83292193
136membrane lipid catabolic process (GO:0046466)2.83083101
137eosinophil migration (GO:0072677)2.82191016
138positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78808010
139fructose metabolic process (GO:0006000)2.78019898
140monosaccharide biosynthetic process (GO:0046364)2.76600234
141regulation of vitamin metabolic process (GO:0030656)2.74798227
142cellular response to arsenic-containing substance (GO:0071243)2.73897733
143barbed-end actin filament capping (GO:0051016)2.71262397
144gluconeogenesis (GO:0006094)2.70005700
145regulation of cholesterol homeostasis (GO:2000188)2.68840733
146amino sugar catabolic process (GO:0046348)2.67715486
147protein activation cascade (GO:0072376)2.67068800
148protein-lipid complex assembly (GO:0065005)2.65594151
149pinocytosis (GO:0006907)2.62544325
150regulation of humoral immune response (GO:0002920)2.62270401
151exogenous drug catabolic process (GO:0042738)2.60063884
152positive regulation of lipid storage (GO:0010884)2.59137236
153adhesion of symbiont to host (GO:0044406)2.57861490
154response to peptidoglycan (GO:0032494)2.57776150
155hexose biosynthetic process (GO:0019319)2.57717228
156hyaluronan catabolic process (GO:0030214)2.53697899
157protein localization to endosome (GO:0036010)2.52668442
158androgen biosynthetic process (GO:0006702)2.52392216
159cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.51929303
160regulation of apoptotic cell clearance (GO:2000425)2.50411505
161positive regulation of humoral immune response (GO:0002922)2.48883341
162myeloid dendritic cell differentiation (GO:0043011)2.47969221
163detection of external biotic stimulus (GO:0098581)2.47238108
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.46444637
165negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44443767
166vitamin D metabolic process (GO:0042359)2.44295956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.29779013
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.62666628
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.15751286
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.80572639
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.31774473
6* LXR_22158963_ChIP-Seq_LIVER_Mouse5.20410615
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19514780
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.13108386
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.33388358
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.25066030
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.19323452
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.10831419
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.60199338
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.53594944
15GATA1_22025678_ChIP-Seq_K562_Human2.16320916
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15437896
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11706430
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.03161635
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01039853
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95043139
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94275587
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85399407
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85201242
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84832281
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81640255
26* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77553276
27TFEB_21752829_ChIP-Seq_HELA_Human1.76723002
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.76176448
29* CLOCK_20551151_ChIP-Seq_293T_Human1.75608128
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71726213
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71704466
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69897579
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66616003
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62641111
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55068392
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52633137
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44998292
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.41797309
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.39348014
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36155930
41* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34674669
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26934209
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23240042
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16263831
45HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12823965
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10602191
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10049980
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09910034
49SPI1_23127762_ChIP-Seq_K562_Human1.08325240
50* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05720032
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04277547
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01832622
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01779480
54SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99581255
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98959896
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98318440
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98028385
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97283859
59RACK7_27058665_Chip-Seq_MCF-7_Human0.96970262
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96346829
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96188221
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93405920
63ATF3_27146783_Chip-Seq_COLON_Human0.93153998
64RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92883495
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92882982
66* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92144427
67* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92054451
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91114054
69AR_21909140_ChIP-Seq_LNCAP_Human0.91037048
70ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90620759
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90290578
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89770986
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86727609
74* GATA4_25053715_ChIP-Seq_YYC3_Human0.86643705
75GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86082537
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85772250
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85113188
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84880949
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84134099
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84134099
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83716873
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82819379
83STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81963508
84* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81256965
85* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80184040
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80109864
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79376522
88PU_27001747_Chip-Seq_BMDM_Mouse0.77926395
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76579820
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76092343
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75719211
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75273252
93HTT_18923047_ChIP-ChIP_STHdh_Human0.74932058
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.74684857
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74225292
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73936536
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73368414
98* LXR_22292898_ChIP-Seq_THP-1_Human0.73103620
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.72554856
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72527469
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71431351
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70847459
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70393096
104VDR_24763502_ChIP-Seq_THP-1_Human0.70008172
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70007137
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68387199
107EGR1_19032775_ChIP-ChIP_M12_Human0.68175454
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67835087
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.67612885
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67087890
111ZNF263_19887448_ChIP-Seq_K562_Human0.66481825
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.65817867
113* GATA2_19941826_ChIP-Seq_K562_Human0.65327221
114VDR_24787735_ChIP-Seq_THP-1_Human0.65258562
115SOX2_20726797_ChIP-Seq_SW620_Human0.64273986
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62106431
117CEBPB_22108803_ChIP-Seq_LS180_Human0.62030291
118* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61936189
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61896169
120PPAR_26484153_Chip-Seq_NCI-H1993_Human0.61738243
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61322727
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.60910744
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.60910744
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60746486
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.60581157
126* SPI1_23547873_ChIP-Seq_NB4_Human0.60480884
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.60358927
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.60108436
129* SPI1_20517297_ChIP-Seq_HL60_Human0.60056781
130SCL_19346495_ChIP-Seq_HPC-7_Human0.60023120
131VDR_21846776_ChIP-Seq_THP-1_Human0.59905746
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.59790795
133GATA1_19941826_ChIP-Seq_K562_Human0.58178320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.40673637
2MP0005360_urolithiasis5.83977913
3MP0005085_abnormal_gallbladder_physiolo4.89577204
4MP0005365_abnormal_bile_salt4.77555380
5MP0008875_abnormal_xenobiotic_pharmacok4.66831093
6MP0003806_abnormal_nucleotide_metabolis3.21019931
7MP0010329_abnormal_lipoprotein_level3.14759795
8MP0009840_abnormal_foam_cell3.04197542
9MP0003252_abnormal_bile_duct2.85627884
10MP0003191_abnormal_cellular_cholesterol2.72368210
11MP0005083_abnormal_biliary_tract2.70263910
12MP0003195_calcinosis2.45343796
13MP0005332_abnormal_amino_acid2.40205730
14MP0003186_abnormal_redox_activity2.10904136
15MP0000609_abnormal_liver_physiology2.01544790
16MP0003436_decreased_susceptibility_to2.00558509
17MP0005319_abnormal_enzyme/_coenzyme1.99493110
18MP0003724_increased_susceptibility_to1.98953124
19MP0002118_abnormal_lipid_homeostasis1.95846174
20MP0003329_amyloid_beta_deposits1.93904000
21MP0001666_abnormal_nutrient_absorption1.92183646
22MP0004510_myositis1.89640989
23MP0004019_abnormal_vitamin_homeostasis1.78739021
24MP0009785_altered_susceptibility_to1.77116380
25MP0002138_abnormal_hepatobiliary_system1.73862522
26MP0009764_decreased_sensitivity_to1.65645619
27MP0005584_abnormal_enzyme/coenzyme_acti1.63619302
28MP0001764_abnormal_homeostasis1.60103886
29MP0008260_abnormal_autophagy1.55775042
30MP0003303_peritoneal_inflammation1.50199392
31MP0000751_myopathy1.48549922
32MP0002877_abnormal_melanocyte_morpholog1.48225105
33MP0002419_abnormal_innate_immunity1.45886746
34MP0008469_abnormal_protein_level1.42926468
35MP0009643_abnormal_urine_homeostasis1.41925641
36MP0004233_abnormal_muscle_weight1.39915832
37MP0004130_abnormal_muscle_cell1.38738626
38MP0003656_abnormal_erythrocyte_physiolo1.37901133
39MP0005451_abnormal_body_composition1.36000273
40MP0001835_abnormal_antigen_presentation1.32871953
41MP0005058_abnormal_lysosome_morphology1.31728436
42MP0005670_abnormal_white_adipose1.31097920
43MP0010234_abnormal_vibrissa_follicle1.27944244
44MP0009333_abnormal_splenocyte_physiolog1.27586813
45MP0005464_abnormal_platelet_physiology1.27269179
46MP0009763_increased_sensitivity_to1.26354352
47MP0003950_abnormal_plasma_membrane1.25385878
48MP0005025_abnormal_response_to1.25213576
49MP0005165_increased_susceptibility_to1.24964700
50MP0008004_abnormal_stomach_pH1.23697464
51MP0004782_abnormal_surfactant_physiolog1.23397538
52MP0000604_amyloidosis1.18477036
53MP0000598_abnormal_liver_morphology1.16434391
54MP0002332_abnormal_exercise_endurance1.15953936
55MP0002837_dystrophic_cardiac_calcinosis1.15051047
56MP0000343_altered_response_to1.14191842
57MP0006082_CNS_inflammation1.12607573
58MP0001853_heart_inflammation1.12108146
59MP0003453_abnormal_keratinocyte_physiol1.11096374
60MP0002998_abnormal_bone_remodeling1.10555331
61MP0003075_altered_response_to1.10125564
62MP0006036_abnormal_mitochondrial_physio1.08422241
63MP0005671_abnormal_response_to1.07776374
64MP0000747_muscle_weakness1.06500310
65MP0003448_altered_tumor_morphology1.05078126
66MP0000858_altered_metastatic_potential1.03841963
67MP0002971_abnormal_brown_adipose1.01086984
68MP0002148_abnormal_hypersensitivity_rea1.00284335
69MP0003566_abnormal_cell_adhesion1.00104718
70MP0003646_muscle_fatigue1.00068457
71MP0001533_abnormal_skeleton_physiology0.98895133
72MP0003705_abnormal_hypodermis_morpholog0.98847150
73MP0001845_abnormal_inflammatory_respons0.98591151
74MP0000749_muscle_degeneration0.95597803
75MP0003868_abnormal_feces_composition0.94890664
76MP0005636_abnormal_mineral_homeostasis0.94339853
77MP0005535_abnormal_body_temperature0.93731028
78MP0003828_pulmonary_edema0.93331071
79MP0005376_homeostasis/metabolism_phenot0.92885364
80MP0009697_abnormal_copulation0.92859964
81MP0003690_abnormal_glial_cell0.91962490
82MP0002254_reproductive_system_inflammat0.91515668
83MP0009642_abnormal_blood_homeostasis0.89230976
84MP0002269_muscular_atrophy0.87900216
85MP0005164_abnormal_response_to0.87357581
86MP0005647_abnormal_sex_gland0.85001249
87MP0002420_abnormal_adaptive_immunity0.83997961
88MP0001819_abnormal_immune_cell0.83931678
89MP0001756_abnormal_urination0.83509234
90MP0003091_abnormal_cell_migration0.83504164
91MP0005166_decreased_susceptibility_to0.83029228
92MP0005000_abnormal_immune_tolerance0.82886082
93MP0005334_abnormal_fat_pad0.82741681
94MP0005023_abnormal_wound_healing0.82714415
95MP0002876_abnormal_thyroid_physiology0.81795229
96MP0005167_abnormal_blood-brain_barrier0.79845172
97MP0005666_abnormal_adipose_tissue0.79620414
98MP0004036_abnormal_muscle_relaxation0.78253071
99MP0000920_abnormal_myelination0.77460728
100MP0003011_delayed_dark_adaptation0.77088638
101MP0002078_abnormal_glucose_homeostasis0.77086449
102MP0002972_abnormal_cardiac_muscle0.76490630
103MP0005266_abnormal_metabolism0.76457197
104MP0003172_abnormal_lysosome_physiology0.76293647
105MP0002136_abnormal_kidney_physiology0.75932505
106MP0000750_abnormal_muscle_regeneration0.74803675
107MP0000249_abnormal_blood_vessel0.74516330
108MP0010368_abnormal_lymphatic_system0.72097147
109MP0009115_abnormal_fat_cell0.71553434
110MP0004087_abnormal_muscle_fiber0.71269915
111MP0003879_abnormal_hair_cell0.71248845
112MP0001661_extended_life_span0.71047100
113MP0001915_intracranial_hemorrhage0.69483611
114MP0003221_abnormal_cardiomyocyte_apopto0.66219169
115MP0005408_hypopigmentation0.66001201
116MP0005387_immune_system_phenotype0.64300143
117MP0001790_abnormal_immune_system0.64300143
118MP0009765_abnormal_xenobiotic_induced0.63885496
119MP0000685_abnormal_immune_system0.63656885
120MP0008873_increased_physiological_sensi0.63412403
121MP0002723_abnormal_immune_serum0.60937275
122MP0010155_abnormal_intestine_physiology0.60734311
123MP0002452_abnormal_antigen_presenting0.60036300
124MP0004947_skin_inflammation0.59994007
125MP0005330_cardiomyopathy0.59904129
126MP0005448_abnormal_energy_balance0.58910842
127MP0005084_abnormal_gallbladder_morpholo0.57471869
128MP0003300_gastrointestinal_ulcer0.56148249
129MP0008874_decreased_physiological_sensi0.54578334
130MP0001800_abnormal_humoral_immune0.54009472
131MP0002166_altered_tumor_susceptibility0.53733997
132MP0004883_abnormal_blood_vessel0.52449513
133MP0005385_cardiovascular_system_phenoty0.51365376
134MP0001544_abnormal_cardiovascular_syste0.51365376

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.44711683
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.36399801
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.15267118
4Abnormality of glycolipid metabolism (HP:0010969)5.14082416
5Abnormality of liposaccharide metabolism (HP:0010968)5.14082416
6Abnormality of glycosphingolipid metabolism (HP:0004343)5.14082416
7Xanthomatosis (HP:0000991)5.08249884
8Intrahepatic cholestasis (HP:0001406)5.00137584
9Prolonged partial thromboplastin time (HP:0003645)4.94727688
10Hypobetalipoproteinemia (HP:0003563)4.58266510
11Joint hemorrhage (HP:0005261)4.56458101
12Recurrent gram-negative bacterial infections (HP:0005420)4.54598022
13Hyperlipoproteinemia (HP:0010980)4.44256985
14Complement deficiency (HP:0004431)4.12944197
15Hyperammonemia (HP:0001987)4.06979551
16Hypoglycemic coma (HP:0001325)3.90353586
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.88551715
18Hyperglycinuria (HP:0003108)3.87351543
19Ketosis (HP:0001946)3.82844739
20Abnormality of fatty-acid metabolism (HP:0004359)3.80867271
21Abnormality of the common coagulation pathway (HP:0010990)3.69302683
22Hypolipoproteinemia (HP:0010981)3.65151644
23Epidermoid cyst (HP:0200040)3.59259650
24Abnormality of glycine metabolism (HP:0010895)3.56288041
25Abnormality of serine family amino acid metabolism (HP:0010894)3.56288041
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49115130
27Eczematoid dermatitis (HP:0000976)3.44417488
28Hypoalphalipoproteinemia (HP:0003233)3.43485084
29Hyperglycinemia (HP:0002154)3.34947285
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30371868
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27178614
32Hypercholesterolemia (HP:0003124)3.25910711
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.25057962
34Abnormality of methionine metabolism (HP:0010901)3.23314386
35Abnormality of complement system (HP:0005339)3.22428831
36Abnormality of pyrimidine metabolism (HP:0004353)3.20325114
37Systemic lupus erythematosus (HP:0002725)3.15843495
38Fat malabsorption (HP:0002630)3.11121552
39Abnormal gallbladder physiology (HP:0012438)3.08776839
40Cholecystitis (HP:0001082)3.08776839
41Loss of speech (HP:0002371)3.07450658
42Abnormality of the intrinsic pathway (HP:0010989)3.01636090
43Ketoacidosis (HP:0001993)3.01593032
44Myocardial infarction (HP:0001658)2.96183949
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95798149
46Dicarboxylic aciduria (HP:0003215)2.95798149
47Nausea (HP:0002018)2.92594022
48Abnormality of nucleobase metabolism (HP:0010932)2.86026402
49Neurofibrillary tangles (HP:0002185)2.85565549
50Recurrent bacterial skin infections (HP:0005406)2.84857104
51Dysostosis multiplex (HP:0000943)2.77045880
52Hyperbilirubinemia (HP:0002904)2.74922145
53Generalized aminoaciduria (HP:0002909)2.72858879
54Abnormality of purine metabolism (HP:0004352)2.68877047
55Asymmetric septal hypertrophy (HP:0001670)2.68854863
56Metabolic acidosis (HP:0001942)2.60428045
57Recurrent abscess formation (HP:0002722)2.56718728
58Abnormality of polysaccharide metabolism (HP:0011012)2.52744690
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52744690
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52744690
61Mutism (HP:0002300)2.50938785
62Steatorrhea (HP:0002570)2.49016836
63Abnormality of glycolysis (HP:0004366)2.48466427
64Skin nodule (HP:0200036)2.48140250
65Abnormality of serum amino acid levels (HP:0003112)2.47969324
66Hepatocellular carcinoma (HP:0001402)2.47271808
67Conjugated hyperbilirubinemia (HP:0002908)2.46739456
68Distal lower limb muscle weakness (HP:0009053)2.46381269
69Mucopolysacchariduria (HP:0008155)2.45094815
70Urinary glycosaminoglycan excretion (HP:0003541)2.45094815
71Increased cerebral lipofuscin (HP:0011813)2.43846187
72Abnormality of proline metabolism (HP:0010907)2.39209548
73Hydroxyprolinuria (HP:0003080)2.39209548
74Lethargy (HP:0001254)2.39103843
75Axonal loss (HP:0003447)2.38941562
76Ragged-red muscle fibers (HP:0003200)2.38496209
77Glomerulonephritis (HP:0000099)2.35943966
78Amyloidosis (HP:0011034)2.32775304
79Apathy (HP:0000741)2.32665436
80Gout (HP:0001997)2.31948694
81Delayed CNS myelination (HP:0002188)2.31733291
82Esophageal varix (HP:0002040)2.31261930
83Cerebral inclusion bodies (HP:0100314)2.30207820
84Increased serum pyruvate (HP:0003542)2.29872277
85Exercise-induced myalgia (HP:0003738)2.29167317
86Pancreatitis (HP:0001733)2.28716960
87Centrally nucleated skeletal muscle fibers (HP:0003687)2.27709543
88Cerebral edema (HP:0002181)2.27678158
89Gingival bleeding (HP:0000225)2.25629231
90Diminished motivation (HP:0000745)2.25548136
91Thrombophlebitis (HP:0004418)2.23526124
92Vascular calcification (HP:0004934)2.19991044
93Proximal tubulopathy (HP:0000114)2.18797464
94Upper motor neuron abnormality (HP:0002127)2.16484669
95Disinhibition (HP:0000734)2.16230831
96Autoimmune thrombocytopenia (HP:0001973)2.15375011
97Vomiting (HP:0002013)2.14362491
98Spastic diplegia (HP:0001264)2.12313943
99Cholelithiasis (HP:0001081)2.10681849
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10564556
101Hemorrhage of the eye (HP:0011885)2.10557814
102Vertebral compression fractures (HP:0002953)2.10048860
103Increased serum ferritin (HP:0003281)2.09309409
104Abnormal gallbladder morphology (HP:0012437)2.08782544
105Purpura (HP:0000979)2.06603753
106Abnormality of iron homeostasis (HP:0011031)2.05771555
107Mitral stenosis (HP:0001718)2.05627052
108Abnormality of macrophages (HP:0004311)2.04981878
109EMG: myopathic abnormalities (HP:0003458)2.03323514
110Menorrhagia (HP:0000132)2.02724843
111Hepatosplenomegaly (HP:0001433)1.99944251
112Neuronal loss in central nervous system (HP:0002529)1.99708077
113Hypertriglyceridemia (HP:0002155)1.99427299
114Renal cortical cysts (HP:0000803)1.98841525
115Pulmonary embolism (HP:0002204)1.96864763
116Vacuolated lymphocytes (HP:0001922)1.96737434
117Abnormality of transition element cation homeostasis (HP:0011030)1.96549948
118Nephritis (HP:0000123)1.95538728
119Periodontitis (HP:0000704)1.95338040
120Sensorimotor neuropathy (HP:0007141)1.95135780
121Increased connective tissue (HP:0009025)1.95045118
122Cardiovascular calcification (HP:0011915)1.94242820
123Hypokinesia (HP:0002375)1.93678156
124Nemaline bodies (HP:0003798)1.93544960
125Bone pain (HP:0002653)1.93020106
126Neonatal onset (HP:0003623)1.92756998
127Spontaneous abortion (HP:0005268)1.91647983
128Myoglobinuria (HP:0002913)1.91186277
129Muscle fiber inclusion bodies (HP:0100299)1.91041155
130Abnormal cartilage morphology (HP:0002763)1.90517235
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90391175
132Recurrent skin infections (HP:0001581)1.89133890
133Malnutrition (HP:0004395)1.88643397
134Late onset (HP:0003584)1.87306239
135Gingivitis (HP:0000230)1.86837164
136Irritability (HP:0000737)1.85720416
137Hypoglycemic seizures (HP:0002173)1.83285995
138Elevated alkaline phosphatase (HP:0003155)1.81890646
139Nuclear cataract (HP:0100018)1.81263224
140Mediastinal lymphadenopathy (HP:0100721)1.80439185
141Rhabdomyolysis (HP:0003201)1.80339571
142Urticaria (HP:0001025)1.80252822
143Prolonged neonatal jaundice (HP:0006579)1.79609142
144Epistaxis (HP:0000421)1.78255400
145Progressive neurologic deterioration (HP:0002344)1.77447356
146Tetraparesis (HP:0002273)1.77400588
147Glycosuria (HP:0003076)1.76929168
148Exercise-induced muscle cramps (HP:0003710)1.75177418
149Orchitis (HP:0100796)1.74861983
150Pathologic fracture (HP:0002756)1.73487759
151Joint swelling (HP:0001386)1.70949403
152Interstitial pulmonary disease (HP:0006530)1.69050776
153Abnormality of the gallbladder (HP:0005264)1.69031416
154Increased neuronal autofluorescent lipopigment (HP:0002074)1.66920140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.70293745
2ERN14.55450999
3NME23.14572498
4MAP3K142.74672928
5FGFR42.65711613
6TAOK32.57824641
7IRAK32.49312330
8SIK12.46877269
9TRIB32.45770821
10TBK12.37432694
11PRPF4B2.31518603
12ARAF2.30758023
13IRAK42.28380630
14PKN22.20582598
15TYK22.13154300
16MST1R2.06802113
17TAOK22.05888576
18PBK2.00171027
19ABL21.99280783
20TESK21.96315679
21BLK1.80385272
22RIPK41.79695733
23NEK91.76691422
24MAP2K31.75472042
25PAK41.72126697
26ERBB41.70014539
27EPHB11.67891393
28JAK11.62755037
29MOS1.62102168
30LIMK11.61743344
31FLT31.54545116
32MYLK1.50568546
33TIE11.49796572
34KSR21.44336772
35DDR21.40387840
36KDR1.38554150
37IKBKE1.37890342
38TTN1.36113920
39MAP3K31.32878352
40JAK21.32725983
41PDK41.28107511
42PDK31.28107511
43PIK3CG1.26831651
44INSRR1.23874943
45GRK71.23603757
46MAP4K11.23307035
47RIPK11.19259437
48EIF2AK31.18613144
49MAP3K91.15813018
50KIT1.15206151
51CSK1.13390613
52ICK1.12133188
53MAP3K121.07026409
54MAPK111.05135664
55PDK21.04965590
56MAP3K111.04632417
57PTK61.03204345
58DAPK21.02791771
59ZAP700.99428843
60PIM20.99107505
61EPHA30.94365873
62MAP3K80.92450495
63NEK10.88689438
64SMG10.88571119
65IKBKB0.88311597
66MAPK40.87916058
67MAP3K50.86253692
68STK40.84112069
69JAK30.80924323
70TEC0.80708519
71BUB10.80307003
72TAOK10.79924249
73EPHA20.79010849
74TGFBR20.78474653
75BTK0.78179223
76CDC42BPA0.76325087
77PRKAA20.74791822
78FGR0.74781089
79PDPK10.73880370
80GRK60.71713964
81CDK120.71578445
82TESK10.70565271
83STK240.67959027
84PINK10.67881768
85TSSK60.67494586
86FGFR30.67475690
87MAP2K40.67138880
88CAMK1D0.66764278
89SCYL20.65770038
90AKT20.65463100
91AKT30.63669120
92FRK0.63170763
93BMX0.63091073
94TRPM70.62329427
95RAF10.62039506
96LMTK20.60493911
97CSF1R0.60391684
98KSR10.59943790
99CSNK1G30.59396173
100SYK0.58935481
101PRKCD0.57835438
102LRRK20.56747592
103OBSCN0.56290821
104BRAF0.54740463
105RPS6KA60.53991811
106CHUK0.53984277
107MAPKAPK30.53901367
108IRAK10.53614837
109DMPK0.51937824
110CAMKK20.51284164
111CDK60.51045994
112RPS6KC10.50901715
113RPS6KL10.50901715
114LATS20.50614142
115PHKG20.50469764
116PHKG10.50469764
117HCK0.50394646
118SRPK10.50207561
119PRKACG0.49163286
120LYN0.48720525
121TXK0.48372252
122ABL10.48319158
123MST40.47671976
124CAMK2G0.45961963
125GSK3A0.44153486
126MAPK120.43853249
127MAP3K10.43806973
128PIM10.42801901
129PIK3CA0.42322688
130PDK10.41921262
131ALK0.41829600
132SIK30.41517449
133EGFR0.40977827
134DAPK10.40576486
135STK100.40035792
136DAPK30.38710003
137PRKCQ0.35857963
138MATK0.35713866
139CDK40.35281217
140ITK0.34501211
141PRKCZ0.33983912
142MAP3K130.33629842
143EIF2AK10.32792834
144PRKAA10.31813745
145RPS6KA20.31496453
146MAP3K70.30157122

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.79626582
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23639844
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15097777
4Nitrogen metabolism_Homo sapiens_hsa009102.71910477
5Arginine biosynthesis_Homo sapiens_hsa002202.70202642
6Fatty acid degradation_Homo sapiens_hsa000712.69158779
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.52845511
8Tryptophan metabolism_Homo sapiens_hsa003802.48495233
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47927341
10Complement and coagulation cascades_Homo sapiens_hsa046102.46446821
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37111858
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33748643
13Propanoate metabolism_Homo sapiens_hsa006402.19459593
14Peroxisome_Homo sapiens_hsa041462.18008916
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16549780
16Staphylococcus aureus infection_Homo sapiens_hsa051502.13157403
17PPAR signaling pathway_Homo sapiens_hsa033202.07147297
18Caffeine metabolism_Homo sapiens_hsa002322.02321228
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96942620
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96836747
21Chemical carcinogenesis_Homo sapiens_hsa052041.95275628
22Fatty acid metabolism_Homo sapiens_hsa012121.94807877
23Butanoate metabolism_Homo sapiens_hsa006501.84757014
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.84564505
25* Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84291467
26beta-Alanine metabolism_Homo sapiens_hsa004101.80641863
27Histidine metabolism_Homo sapiens_hsa003401.79822932
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.61278479
29Starch and sucrose metabolism_Homo sapiens_hsa005001.60281909
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51245501
31Carbon metabolism_Homo sapiens_hsa012001.48889254
32Phenylalanine metabolism_Homo sapiens_hsa003601.46374736
33Retinol metabolism_Homo sapiens_hsa008301.42435064
34Pyruvate metabolism_Homo sapiens_hsa006201.38711322
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38219485
36Selenocompound metabolism_Homo sapiens_hsa004501.36571200
37Sulfur metabolism_Homo sapiens_hsa009201.35285373
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31988679
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27647401
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20472571
41Bile secretion_Homo sapiens_hsa049761.19162131
42Tyrosine metabolism_Homo sapiens_hsa003501.17642328
43Biosynthesis of amino acids_Homo sapiens_hsa012301.17206981
44Fatty acid elongation_Homo sapiens_hsa000621.15690696
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11973124
46ABC transporters_Homo sapiens_hsa020101.09901042
47Vibrio cholerae infection_Homo sapiens_hsa051101.09066862
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.07022395
49Glutathione metabolism_Homo sapiens_hsa004801.05290182
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04646545
51Fat digestion and absorption_Homo sapiens_hsa049751.03333279
52Pentose phosphate pathway_Homo sapiens_hsa000301.01876366
53Sulfur relay system_Homo sapiens_hsa041221.01837836
54Folate biosynthesis_Homo sapiens_hsa007901.01227424
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97027004
56* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94363392
57Salmonella infection_Homo sapiens_hsa051320.86319092
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84448808
59Collecting duct acid secretion_Homo sapiens_hsa049660.82328170
60Arginine and proline metabolism_Homo sapiens_hsa003300.79526055
61Ovarian steroidogenesis_Homo sapiens_hsa049130.75913982
62Glycerolipid metabolism_Homo sapiens_hsa005610.75703620
63Steroid biosynthesis_Homo sapiens_hsa001000.74064730
64Galactose metabolism_Homo sapiens_hsa000520.69514829
65Proteasome_Homo sapiens_hsa030500.69045976
66Allograft rejection_Homo sapiens_hsa053300.67263927
67Mineral absorption_Homo sapiens_hsa049780.64271053
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63356581
69Fatty acid biosynthesis_Homo sapiens_hsa000610.62525289
70Lysine degradation_Homo sapiens_hsa003100.60850231
71Vitamin B6 metabolism_Homo sapiens_hsa007500.60460377
72Leishmaniasis_Homo sapiens_hsa051400.57867413
73Asthma_Homo sapiens_hsa053100.57406627
74Viral myocarditis_Homo sapiens_hsa054160.57329934
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.54536812
76Legionellosis_Homo sapiens_hsa051340.53967464
77Fructose and mannose metabolism_Homo sapiens_hsa000510.53744072
78Shigellosis_Homo sapiens_hsa051310.53416066
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52394010
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.51311708
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49956232
82Toxoplasmosis_Homo sapiens_hsa051450.49747173
83Sphingolipid metabolism_Homo sapiens_hsa006000.49479482
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49285882
85Antigen processing and presentation_Homo sapiens_hsa046120.48271782
86One carbon pool by folate_Homo sapiens_hsa006700.45954543
87Insulin resistance_Homo sapiens_hsa049310.45327874
88Apoptosis_Homo sapiens_hsa042100.44751959
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.44405650
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44274300
91Autoimmune thyroid disease_Homo sapiens_hsa053200.43138052
92* Metabolic pathways_Homo sapiens_hsa011000.41289371
93Pertussis_Homo sapiens_hsa051330.40596309
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40539961
95Lysosome_Homo sapiens_hsa041420.35774425
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34171039
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33348507
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33304700
99Systemic lupus erythematosus_Homo sapiens_hsa053220.32001367
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31984709
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.30721581
102Measles_Homo sapiens_hsa051620.30708942
103Phagosome_Homo sapiens_hsa041450.29730434
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26001408
105Prion diseases_Homo sapiens_hsa050200.23698855
106Malaria_Homo sapiens_hsa051440.22769632
107African trypanosomiasis_Homo sapiens_hsa051430.20761622
108Graft-versus-host disease_Homo sapiens_hsa053320.20175737
109Tuberculosis_Homo sapiens_hsa051520.19282395
110Renin-angiotensin system_Homo sapiens_hsa046140.18795445
111Other glycan degradation_Homo sapiens_hsa005110.14964159
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14413423
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14352437
114Osteoclast differentiation_Homo sapiens_hsa043800.13702763
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.13166340
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12664664
117Rheumatoid arthritis_Homo sapiens_hsa053230.10269963
118Hepatitis C_Homo sapiens_hsa051600.06297461
119Amoebiasis_Homo sapiens_hsa051460.04928321
120Influenza A_Homo sapiens_hsa051640.04843945
121Glucagon signaling pathway_Homo sapiens_hsa049220.02936892
122TNF signaling pathway_Homo sapiens_hsa046680.02832975
123AMPK signaling pathway_Homo sapiens_hsa041520.02151133

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