ALAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* heme biosynthetic process (GO:0006783)9.89912558
2* tetrapyrrole biosynthetic process (GO:0033014)9.55059817
3* porphyrin-containing compound metabolic process (GO:0006778)8.90982076
4oxygen transport (GO:0015671)8.34557132
5* heme metabolic process (GO:0042168)8.19334596
6erythrocyte maturation (GO:0043249)7.76222995
7response to methylmercury (GO:0051597)7.64263980
8gas transport (GO:0015669)6.94381303
9very-low-density lipoprotein particle assembly (GO:0034379)6.25758718
10response to lead ion (GO:0010288)6.01408541
11response to insecticide (GO:0017085)5.74194839
12* tetrapyrrole metabolic process (GO:0033013)5.72697748
13erythrocyte development (GO:0048821)5.70815202
14plasma lipoprotein particle assembly (GO:0034377)5.41396500
15* hemoglobin metabolic process (GO:0020027)5.36022518
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.17626403
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.17626403
18modulation by symbiont of host immune response (GO:0052553)5.17626403
19positive regulation by symbiont of host defense response (GO:0052509)5.17626403
20modulation by symbiont of host defense response (GO:0052031)5.17626403
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.17626403
22cysteine metabolic process (GO:0006534)5.06935087
23heme transport (GO:0015886)5.05657461
24neutrophil activation involved in immune response (GO:0002283)4.97879459
25positive regulation of gamma-delta T cell activation (GO:0046645)4.96516059
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87585691
27negative regulation of cell killing (GO:0031342)4.87585691
283-UTR-mediated mRNA stabilization (GO:0070935)4.80514650
29protein-lipid complex assembly (GO:0065005)4.74900387
30L-phenylalanine catabolic process (GO:0006559)4.60910553
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.60910553
32detection of other organism (GO:0098543)4.57457334
33regulation of B cell receptor signaling pathway (GO:0050855)4.49026206
34positive regulation of fibroblast migration (GO:0010763)4.46870080
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.46312121
36response to arsenic-containing substance (GO:0046685)4.46128454
37negative regulation of fibrinolysis (GO:0051918)4.44390357
38detection of bacterium (GO:0016045)4.39737982
39positive regulation of granulocyte differentiation (GO:0030854)4.39145185
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.37531274
41L-phenylalanine metabolic process (GO:0006558)4.37531274
42microglial cell activation (GO:0001774)4.37498515
43* pigment biosynthetic process (GO:0046148)4.35529206
44aromatic amino acid family catabolic process (GO:0009074)4.33684868
45regulation of platelet aggregation (GO:0090330)4.32440674
46lysine metabolic process (GO:0006553)4.29738355
47lysine catabolic process (GO:0006554)4.29738355
48hepatocyte apoptotic process (GO:0097284)4.28639805
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18667314
50response to peptidoglycan (GO:0032494)4.15600610
51regulation of protein activation cascade (GO:2000257)4.14825449
52regulation of fibrinolysis (GO:0051917)4.13391692
53glyoxylate metabolic process (GO:0046487)4.11959237
54indole-containing compound catabolic process (GO:0042436)4.07887803
55indolalkylamine catabolic process (GO:0046218)4.07887803
56tryptophan catabolic process (GO:0006569)4.07887803
57kynurenine metabolic process (GO:0070189)4.03566918
58detection of molecule of bacterial origin (GO:0032490)4.00557821
59detection of external biotic stimulus (GO:0098581)3.98806966
60regulation of response to osmotic stress (GO:0047484)3.98119760
61macrophage activation involved in immune response (GO:0002281)3.95820280
62high-density lipoprotein particle remodeling (GO:0034375)3.95301884
63* pigment metabolic process (GO:0042440)3.95020094
64plasma lipoprotein particle organization (GO:0071827)3.92115691
65regulation of complement activation (GO:0030449)3.91694748
66modulation by virus of host process (GO:0019054)3.90499759
67complement activation, alternative pathway (GO:0006957)3.83463752
68leukocyte aggregation (GO:0070486)3.80908459
69tryptophan metabolic process (GO:0006568)3.80658744
70regulation of necroptotic process (GO:0060544)3.77757139
71regulation of cytokine secretion involved in immune response (GO:0002739)3.76631863
72viral protein processing (GO:0019082)3.74314038
73negative regulation of cAMP-mediated signaling (GO:0043951)3.72966163
74iron ion import (GO:0097286)3.72931813
75bile acid biosynthetic process (GO:0006699)3.72431474
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72276371
77neutrophil mediated immunity (GO:0002446)3.70833974
78negative regulation of necroptotic process (GO:0060546)3.69971565
79regulation of triglyceride catabolic process (GO:0010896)3.69021476
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67409462
81alpha-linolenic acid metabolic process (GO:0036109)3.65817590
82reverse cholesterol transport (GO:0043691)3.64968830
83neutrophil activation (GO:0042119)3.63504102
84cellular response to virus (GO:0098586)3.63419237
85protein-lipid complex subunit organization (GO:0071825)3.63136065
86* erythrocyte differentiation (GO:0030218)3.62594249
87negative regulation of interleukin-12 production (GO:0032695)3.62231268
88respiratory burst (GO:0045730)3.61773415
89negative regulation of execution phase of apoptosis (GO:1900118)3.61357034
90myeloid cell development (GO:0061515)3.60709757
91peptidyl-glutamic acid carboxylation (GO:0017187)3.57614848
92protein carboxylation (GO:0018214)3.57614848
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57610829
94response to host immune response (GO:0052572)3.57610829
95cellular extravasation (GO:0045123)3.57049632
96plasma lipoprotein particle clearance (GO:0034381)3.55219236
97* cofactor biosynthetic process (GO:0051188)3.55102375
98GDP-mannose metabolic process (GO:0019673)3.53818508
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.53486951
100cofactor catabolic process (GO:0051187)3.53293363
101phospholipid efflux (GO:0033700)3.52172287
102water-soluble vitamin biosynthetic process (GO:0042364)3.52080022
103antigen processing and presentation of endogenous antigen (GO:0019883)3.51823100
104urea cycle (GO:0000050)3.51626080
105urea metabolic process (GO:0019627)3.51626080
106modulation by symbiont of host cellular process (GO:0044068)3.50010979
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49098254
108one-carbon compound transport (GO:0019755)3.47493711
109macrophage activation (GO:0042116)3.45283633
110amino-acid betaine metabolic process (GO:0006577)3.45270566
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.42924091
112regulation of gamma-delta T cell activation (GO:0046643)3.42303455
113regulation of interferon-beta biosynthetic process (GO:0045357)3.41111998
114detection of biotic stimulus (GO:0009595)3.40151408
115blood coagulation, intrinsic pathway (GO:0007597)3.37930559
116leukocyte migration involved in inflammatory response (GO:0002523)3.37867424
117response to dexamethasone (GO:0071548)3.37672522
118cholesterol efflux (GO:0033344)3.36848706
119plasma lipoprotein particle remodeling (GO:0034369)3.35656199
120protein-lipid complex remodeling (GO:0034368)3.35656199
121macromolecular complex remodeling (GO:0034367)3.35656199
122granulocyte activation (GO:0036230)3.34150219
123nitrogen cycle metabolic process (GO:0071941)3.31688218
124bicarbonate transport (GO:0015701)3.31176265
125negative regulation of glial cell proliferation (GO:0060253)3.30768112
126regulation of mast cell degranulation (GO:0043304)3.28372754
127glycine metabolic process (GO:0006544)3.27639203
128sulfur amino acid catabolic process (GO:0000098)3.27427080
129iron coordination entity transport (GO:1901678)3.27314650
130L-alpha-amino acid transmembrane transport (GO:1902475)3.27211925
131negative regulation of erythrocyte differentiation (GO:0045647)3.26781217
132cellular response to dexamethasone stimulus (GO:0071549)3.26568921
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26181061
134pyridine-containing compound biosynthetic process (GO:0072525)3.26016268
135serine family amino acid metabolic process (GO:0009069)3.25922902
136serine family amino acid catabolic process (GO:0009071)3.25381856
137negative regulation of viral entry into host cell (GO:0046597)3.24305918
138response to host (GO:0075136)3.24275311
139response to host defenses (GO:0052200)3.24275311
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24275311
141homocysteine metabolic process (GO:0050667)3.22714621
142ethanol oxidation (GO:0006069)3.22642146
143positive regulation of insulin receptor signaling pathway (GO:0046628)3.22102212
144response to interleukin-15 (GO:0070672)3.19476428
145positive regulation of lipoprotein lipase activity (GO:0051006)3.17604952
146positive regulation of triglyceride lipase activity (GO:0061365)3.17604952
147regulation of granulocyte differentiation (GO:0030852)3.16971849
148triglyceride homeostasis (GO:0070328)3.16934857
149acylglycerol homeostasis (GO:0055090)3.16934857
150myeloid leukocyte mediated immunity (GO:0002444)3.16862794
151negative regulation of phagocytosis (GO:0050765)3.16730274
152myeloid cell activation involved in immune response (GO:0002275)3.15543936
153response to nitrosative stress (GO:0051409)3.14889777
154negative regulation of T cell mediated immunity (GO:0002710)3.11198348
155arginine metabolic process (GO:0006525)3.10482749
156regulation of cholesterol esterification (GO:0010872)3.09112826
157glutamate metabolic process (GO:0006536)3.07961308
158positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05012972
159cellular hyperosmotic response (GO:0071474)3.04951602
160negative regulation of protein activation cascade (GO:2000258)3.04609123
161antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04248837
162negative regulation of leukocyte mediated immunity (GO:0002704)3.01303991
163regulation of mast cell activation involved in immune response (GO:0033006)3.00538772
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99994874
165bile acid metabolic process (GO:0008206)2.99613568
166regulation of gamma-delta T cell differentiation (GO:0045586)2.99232156
167positive thymic T cell selection (GO:0045059)2.98100441
168aromatic amino acid family metabolic process (GO:0009072)2.97396692
169positive regulation of mast cell activation (GO:0033005)2.96297707
170fibrinolysis (GO:0042730)2.96103139
171mitochondrion degradation (GO:0000422)2.94755814
172alpha-amino acid catabolic process (GO:1901606)2.93324151
173leukocyte degranulation (GO:0043299)2.91457627
174amine catabolic process (GO:0009310)2.91349161
175cellular biogenic amine catabolic process (GO:0042402)2.91349161
176carnitine metabolic process (GO:0009437)2.91135675
177negative regulation of necrotic cell death (GO:0060547)2.90109100
178negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88129482
179nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.87736554
180B cell receptor signaling pathway (GO:0050853)2.82332594
181cellular response to interleukin-15 (GO:0071350)2.81335613
182regulation of mast cell activation (GO:0033003)2.79803056
183production of molecular mediator involved in inflammatory response (GO:0002532)2.78356465
184regulation of leukocyte degranulation (GO:0043300)2.78196849
185megakaryocyte development (GO:0035855)2.75849565
186* protoporphyrinogen IX metabolic process (GO:0046501)16.5652768
187* protoporphyrinogen IX biosynthetic process (GO:0006782)14.3076290
188* porphyrin-containing compound biosynthetic process (GO:0006779)10.7140319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.96819002
2GATA1_22025678_ChIP-Seq_K562_Human6.10257622
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.62962242
4E2F7_22180533_ChIP-Seq_HELA_Human5.16647455
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.96413404
6GATA1_19941826_ChIP-Seq_K562_Human4.61344395
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.60458187
8RXR_22158963_ChIP-Seq_LIVER_Mouse4.43343380
9FOXM1_23109430_ChIP-Seq_U2OS_Human4.41149376
10PPARA_22158963_ChIP-Seq_LIVER_Mouse4.02408085
11* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.72351740
12* GATA1_19941827_ChIP-Seq_MEL_Mouse3.52052895
13IRF8_22096565_ChIP-ChIP_GC-B_Human3.49537455
14* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.48419407
15LXR_22158963_ChIP-Seq_LIVER_Mouse3.34488041
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15250784
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.99171911
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92734979
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87883942
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73006851
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.71313850
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61181616
23* GATA2_19941826_ChIP-Seq_K562_Human2.60713395
24SCL_19346495_ChIP-Seq_HPC-7_Human2.54094127
25SPI1_23547873_ChIP-Seq_NB4_Human2.49626116
26VDR_24763502_ChIP-Seq_THP-1_Human2.49080559
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46095029
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.36347778
29SPI1_23127762_ChIP-Seq_K562_Human2.36164665
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35119494
31* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.20548249
32RUNX_20019798_ChIP-Seq_JUKART_Human2.19484856
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19307889
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17838872
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14234693
36MYB_26560356_Chip-Seq_TH2_Human2.11884560
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10977488
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10441405
39STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07791058
40BP1_19119308_ChIP-ChIP_Hs578T_Human2.07404020
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05571375
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99300995
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99281856
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97853067
45ZNF263_19887448_ChIP-Seq_K562_Human1.95525049
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92803375
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.92427290
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92277353
49MYB_26560356_Chip-Seq_TH1_Human1.91595982
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88579830
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83770570
52MAF_26560356_Chip-Seq_TH2_Human1.73384312
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69820060
54GATA3_27048872_Chip-Seq_THYMUS_Human1.59300939
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58004708
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52007993
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50549459
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49866668
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43419971
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43345604
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40040483
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39158505
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34470923
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32925446
65PU_27001747_Chip-Seq_BMDM_Mouse1.31135578
66CLOCK_20551151_ChIP-Seq_293T_Human1.27383624
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26353811
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26046823
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.25872154
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25063767
71AR_21909140_ChIP-Seq_LNCAP_Human1.24388582
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23908490
73BCL6_27268052_Chip-Seq_Bcells_Human1.22906901
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21019802
75NCOR1_26117541_ChIP-Seq_K562_Human1.20338152
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19291082
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17856101
78* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17556836
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.16151626
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16028194
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14620185
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13310035
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12534307
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11996810
85BCOR_27268052_Chip-Seq_Bcells_Human1.11955961
86* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11032893
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10023839
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05552394
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05298124
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.05093912
91KDM2B_26808549_Chip-Seq_K562_Human1.04569738
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04357479
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03629917
94VDR_24787735_ChIP-Seq_THP-1_Human1.02312653
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01862454
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98452105
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97785379
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96538162
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96333473
100MYC_22102868_ChIP-Seq_BL_Human0.95441826
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95284174
102VDR_21846776_ChIP-Seq_THP-1_Human0.94571071
103MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94406363
104GATA3_26560356_Chip-Seq_TH2_Human0.93259230
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92608943
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.89251196
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86078539
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85044781
109FOXA2_19822575_ChIP-Seq_HepG2_Human0.84516395
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83216221
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82974950
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81159086
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80086259
114MAF_26560356_Chip-Seq_TH1_Human0.79636373
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75696405
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74220379
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74145814
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73472768
119GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73452558
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.73370392
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73201792
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71625277
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71134713
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71090277
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70301247
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.70294779
127HNF4A_19822575_ChIP-Seq_HepG2_Human0.70238558
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69497513
129GATA6_25053715_ChIP-Seq_YYC3_Human0.68886312
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.68529152
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67127622
132UTX_26944678_Chip-Seq_JUKART_Human0.66679907
133SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66019377
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.65385880
135KDM2B_26808549_Chip-Seq_DND41_Human0.63593403
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.63424882
137SPI1_20517297_ChIP-Seq_HL60_Human0.62761779
138* ELF1_20517297_ChIP-Seq_JURKAT_Human0.62740844
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.62639813
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61433006
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.60796161
142ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59660669
143LXR_22292898_ChIP-Seq_THP-1_Human0.59638733
144CTCF_21964334_Chip-Seq_Bcells_Human0.59438568
145KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.58544923
146SALL4_22934838_ChIP-ChIP_CD34+_Human0.57860671
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57622138
148HOXB4_20404135_ChIP-ChIP_EML_Mouse0.57490330
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.57424239
150TCF7_22412390_ChIP-Seq_EML_Mouse0.57191614
151KDM5A_27292631_Chip-Seq_BREAST_Human0.55867264
152* RUNX1_22412390_ChIP-Seq_EML_Mouse0.54895468
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.54562254
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54233681
155CREB1_15753290_ChIP-ChIP_HEK293T_Human0.53637981
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.53577877
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.53554716
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53330417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level8.98265995
2MP0002139_abnormal_hepatobiliary_system5.27978043
3MP0005360_urolithiasis4.48227458
4MP0005083_abnormal_biliary_tract4.06914257
5MP0005085_abnormal_gallbladder_physiolo4.05294446
6MP0003724_increased_susceptibility_to3.70397610
7MP0003436_decreased_susceptibility_to3.37608475
8MP0005365_abnormal_bile_salt3.30725652
9MP0003806_abnormal_nucleotide_metabolis2.69983670
10MP0002419_abnormal_innate_immunity2.60195333
11MP0001835_abnormal_antigen_presentation2.59531792
12MP0008875_abnormal_xenobiotic_pharmacok2.53531261
13MP0005025_abnormal_response_to2.48680861
14MP0009785_altered_susceptibility_to2.41138935
15MP0010329_abnormal_lipoprotein_level2.26703219
16MP0003252_abnormal_bile_duct2.19925549
17MP0001800_abnormal_humoral_immune2.19016677
18MP0001790_abnormal_immune_system2.17774320
19MP0005387_immune_system_phenotype2.17774320
20MP0005671_abnormal_response_to2.15788359
21MP0002420_abnormal_adaptive_immunity2.13341100
22MP0003172_abnormal_lysosome_physiology2.10214133
23MP0001819_abnormal_immune_cell2.10158117
24MP0005000_abnormal_immune_tolerance2.08864459
25MP0002405_respiratory_system_inflammati2.01234781
26MP0006082_CNS_inflammation2.01214480
27MP0003656_abnormal_erythrocyte_physiolo10.1319825
28MP0002723_abnormal_immune_serum1.96127121
29MP0003866_abnormal_defecation1.94974670
30MP0002452_abnormal_antigen_presenting1.86410306
31MP0009840_abnormal_foam_cell1.85748348
32MP0002138_abnormal_hepatobiliary_system1.85288137
33MP0003878_abnormal_ear_physiology1.84219081
34MP0005377_hearing/vestibular/ear_phenot1.84219081
35MP0003763_abnormal_thymus_physiology1.82992041
36MP0009278_abnormal_bone_marrow1.80868186
37MP0000609_abnormal_liver_physiology1.80749440
38MP0003191_abnormal_cellular_cholesterol1.79179431
39MP0005075_abnormal_melanosome_morpholog1.78875767
40* MP0005636_abnormal_mineral_homeostasis1.77908516
41MP0003111_abnormal_nucleus_morphology1.77337783
42MP0000716_abnormal_immune_system1.64928784
43MP0010155_abnormal_intestine_physiology1.57936111
44MP0003186_abnormal_redox_activity1.57429873
45MP0004381_abnormal_hair_follicle1.57302564
46MP0006036_abnormal_mitochondrial_physio1.56393038
47MP0001666_abnormal_nutrient_absorption1.55357676
48MP0000015_abnormal_ear_pigmentation1.54246522
49MP0002148_abnormal_hypersensitivity_rea1.47960688
50MP0005451_abnormal_body_composition1.47936831
51MP0001533_abnormal_skeleton_physiology1.44241549
52MP0005397_hematopoietic_system_phenotyp1.43582204
53MP0001545_abnormal_hematopoietic_system1.43582204
54MP0004947_skin_inflammation1.43380170
55MP0000703_abnormal_thymus_morphology1.41049956
56MP0001845_abnormal_inflammatory_respons1.40625614
57MP0009333_abnormal_splenocyte_physiolog1.40234671
58MP0005332_abnormal_amino_acid1.36776379
59MP0005319_abnormal_enzyme/_coenzyme1.36564208
60MP0005464_abnormal_platelet_physiology1.29296702
61MP0005310_abnormal_salivary_gland1.27497694
62MP0002118_abnormal_lipid_homeostasis1.27186127
63MP0003828_pulmonary_edema1.25377395
64MP0003705_abnormal_hypodermis_morpholog1.23416248
65MP0001764_abnormal_homeostasis1.18660837
66MP0010368_abnormal_lymphatic_system1.16414665
67MP0008775_abnormal_heart_ventricle1.14127081
68MP0005584_abnormal_enzyme/coenzyme_acti1.12559258
69MP0000598_abnormal_liver_morphology1.12513419
70MP0000858_altered_metastatic_potential1.09930449
71MP0003195_calcinosis1.09858332
72MP0009764_decreased_sensitivity_to1.08675855
73MP0003183_abnormal_peptide_metabolism1.08159712
74MP0004883_abnormal_blood_vessel1.07948804
75MP0000490_abnormal_crypts_of1.07846272
76MP0009643_abnormal_urine_homeostasis1.07494011
77MP0001851_eye_inflammation1.07065985
78MP0000465_gastrointestinal_hemorrhage1.05674307
79MP0005501_abnormal_skin_physiology1.05341256
80MP0001663_abnormal_digestive_system1.04964864
81MP0003868_abnormal_feces_composition1.00314009
82MP0005174_abnormal_tail_pigmentation0.99924065
83MP0002277_abnormal_respiratory_mucosa0.98422430
84MP0009763_increased_sensitivity_to0.97600889
85MP0004808_abnormal_hematopoietic_stem0.95185244
86MP0010307_abnormal_tumor_latency0.93746921
87MP0009765_abnormal_xenobiotic_induced0.93222225
88MP0009053_abnormal_anal_canal0.92062028
89MP0002166_altered_tumor_susceptibility0.91802150
90MP0008872_abnormal_physiological_respon0.91032720
91MP0003077_abnormal_cell_cycle0.89180169
92MP0010094_abnormal_chromosome_stability0.88183708
93MP0003453_abnormal_keratinocyte_physiol0.85091634
94MP0005164_abnormal_response_to0.83215494
95MP0009697_abnormal_copulation0.82993661
96MP0002653_abnormal_ependyma_morphology0.82281264
97MP0002132_abnormal_respiratory_system0.81916222
98MP0001873_stomach_inflammation0.79718886
99MP0008260_abnormal_autophagy0.79103471
100MP0004019_abnormal_vitamin_homeostasis0.78970047
101MP0003011_delayed_dark_adaptation0.74388034
102* MP0009931_abnormal_skin_appearance0.73783763
103MP0000689_abnormal_spleen_morphology0.73435714
104MP0002837_dystrophic_cardiac_calcinosis0.71672869
105MP0003045_fibrosis0.71227859
106MP0000749_muscle_degeneration0.69935035
107MP0002398_abnormal_bone_marrow0.69679595
108MP0008874_decreased_physiological_sensi0.69294677
109MP0004130_abnormal_muscle_cell0.68906988
110MP0004510_myositis0.68784477
111MP0003300_gastrointestinal_ulcer0.68494584
112MP0002722_abnormal_immune_system0.66938224
113MP0003690_abnormal_glial_cell0.66830776
114MP0008004_abnormal_stomach_pH0.66011078
115MP0008469_abnormal_protein_level0.66002847
116MP0005376_homeostasis/metabolism_phenot0.65743150
117MP0000685_abnormal_immune_system0.64623931
118MP0000343_altered_response_to0.63606346
119MP0005076_abnormal_cell_differentiation0.63592350
120MP0002332_abnormal_exercise_endurance0.62878700
121MP0008770_decreased_survivor_rate0.61314284
122MP0002998_abnormal_bone_remodeling0.60048247
123MP0005647_abnormal_sex_gland0.59931482
124MP0009642_abnormal_blood_homeostasis0.58988798
125MP0002095_abnormal_skin_pigmentation0.58960702
126MP0005381_digestive/alimentary_phenotyp0.57792340
127MP0003943_abnormal_hepatobiliary_system0.57036167
128MP0001756_abnormal_urination0.56684223
129MP0008995_early_reproductive_senescence0.56095136
130* MP0002429_abnormal_blood_cell0.56093933
131MP0005166_decreased_susceptibility_to0.55981569
132MP0000371_diluted_coat_color0.55617786
133MP0005266_abnormal_metabolism0.53434527
134MP0004264_abnormal_extraembryonic_tissu0.52626080
135MP0005334_abnormal_fat_pad0.52008472
136MP0002877_abnormal_melanocyte_morpholog0.51402046
137MP0009672_abnormal_birth_weight0.49384811
138MP0002019_abnormal_tumor_incidence0.49066706
139MP0002396_abnormal_hematopoietic_system0.47742848
140MP0002971_abnormal_brown_adipose0.47715159
141MP0002078_abnormal_glucose_homeostasis0.47710882
142MP0005535_abnormal_body_temperature0.47105077
143MP0002136_abnormal_kidney_physiology0.45645471
144MP0001544_abnormal_cardiovascular_syste0.44288071
145MP0005385_cardiovascular_system_phenoty0.44288071
146MP0006035_abnormal_mitochondrial_morpho0.44172223
147MP0010771_integument_phenotype0.42556222
148MP0003303_peritoneal_inflammation0.42202126
149MP0008873_increased_physiological_sensi0.41929616
150MP0003221_abnormal_cardiomyocyte_apopto0.41883705
151MP0000604_amyloidosis0.41291935
152MP0002970_abnormal_white_adipose0.40941599
153MP0004215_abnormal_myocardial_fiber0.40010046
154MP0000350_abnormal_cell_proliferation0.39731208
155MP0001191_abnormal_skin_condition0.38442670
156MP0002972_abnormal_cardiac_muscle0.37949262
157MP0000313_abnormal_cell_death0.37648447
158MP0004185_abnormal_adipocyte_glucose0.37609707
159* MP0002086_abnormal_extraembryonic_tissu0.36149959
160MP0001730_embryonic_growth_arrest0.35514057
161MP0001243_abnormal_dermal_layer0.34913463
162MP0003693_abnormal_embryo_hatching0.34694912
163MP0002135_abnormal_kidney_morphology0.33425730
164MP0004197_abnormal_fetal_growth/weight/0.32407054
165MP0003075_altered_response_to0.32230238
166MP0004085_abnormal_heartbeat0.32201974

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)9.31794833
2Reticulocytosis (HP:0001923)7.67023072
3* Cholelithiasis (HP:0001081)6.26791299
4Hyperbilirubinemia (HP:0002904)6.20673700
5Diaphragmatic weakness (HP:0009113)5.84803663
6* Abnormal gallbladder morphology (HP:0012437)5.78170744
7Paralysis (HP:0003470)5.67841634
8Eczematoid dermatitis (HP:0000976)5.62619435
9Abnormal gallbladder physiology (HP:0012438)5.38747553
10Cholecystitis (HP:0001082)5.38747553
11Recurrent abscess formation (HP:0002722)5.31792613
12Recurrent bacterial skin infections (HP:0005406)5.26088125
13* Hypochromic anemia (HP:0001931)5.08433750
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.04431796
15Abnormality of reticulocytes (HP:0004312)4.85103022
16Abnormal hemoglobin (HP:0011902)4.83925759
17Deep venous thrombosis (HP:0002625)4.71015508
18Myositis (HP:0100614)4.52974603
19Abnormality of macrophages (HP:0004311)4.45066104
20Hepatocellular carcinoma (HP:0001402)4.44603468
21Osteomalacia (HP:0002749)4.37793763
22Polycythemia (HP:0001901)4.35385067
23Stomatitis (HP:0010280)4.26734240
24Intrahepatic cholestasis (HP:0001406)4.22183172
25Gastrointestinal infarctions (HP:0005244)4.20584581
26Ileus (HP:0002595)4.18609771
27* Abnormality of the gallbladder (HP:0005264)4.13302101
28Orchitis (HP:0100796)4.12701349
29Insomnia (HP:0100785)4.05506312
30Retrobulbar optic neuritis (HP:0100654)3.81560572
31Optic neuritis (HP:0100653)3.81560572
32Xanthomatosis (HP:0000991)3.73511083
33Obstructive lung disease (HP:0006536)3.66112240
34Chronic obstructive pulmonary disease (HP:0006510)3.66112240
35Abnormality of aromatic amino acid family metabolism (HP:0004338)3.64611371
36Slow saccadic eye movements (HP:0000514)3.63003533
37Prolonged partial thromboplastin time (HP:0003645)3.62103454
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.61432207
39Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60346965
40Complement deficiency (HP:0004431)3.60248843
41Elevated erythrocyte sedimentation rate (HP:0003565)3.58556956
42Hypobetalipoproteinemia (HP:0003563)3.40700830
43Recurrent fungal infections (HP:0002841)3.34523764
44Recurrent skin infections (HP:0001581)3.33467765
45* Urticaria (HP:0001025)3.30443458
46Spontaneous hematomas (HP:0007420)3.25841705
47* Microcytic anemia (HP:0001935)3.18572117
48Gingivitis (HP:0000230)3.16363580
49Nausea (HP:0002018)3.15142123
50Meningitis (HP:0001287)3.11911840
51Encephalitis (HP:0002383)3.09481938
52Keratoconjunctivitis sicca (HP:0001097)3.08826951
53Inflammation of the large intestine (HP:0002037)3.02211337
54Mediastinal lymphadenopathy (HP:0100721)2.98125945
55Joint hemorrhage (HP:0005261)2.93981509
56Hypolipoproteinemia (HP:0010981)2.91750160
57* Cutaneous photosensitivity (HP:0000992)2.89543940
58Toxemia of pregnancy (HP:0100603)2.89447250
59Gastrointestinal inflammation (HP:0004386)2.89282546
60Abnormality of iron homeostasis (HP:0011031)2.89017729
61Hyperlipoproteinemia (HP:0010980)2.88552625
62Cellulitis (HP:0100658)2.86489741
63Increased serum ferritin (HP:0003281)2.84327073
64Keratoconjunctivitis (HP:0001096)2.84038790
65Hypoalphalipoproteinemia (HP:0003233)2.83669797
66Episodic fever (HP:0001954)2.82795607
67Vasculitis (HP:0002633)2.81422375
68Abnormality of the common coagulation pathway (HP:0010990)2.79102511
69Cerebral palsy (HP:0100021)2.76772225
70Increased IgE level (HP:0003212)2.75550982
71Anorexia (HP:0002039)2.72298470
72Abnormality of complement system (HP:0005339)2.71421001
73Chronic mucocutaneous candidiasis (HP:0002728)2.69893956
74Recurrent cutaneous fungal infections (HP:0011370)2.69893956
75Hematochezia (HP:0002573)2.66680144
76Abnormality of transition element cation homeostasis (HP:0011030)2.66511006
77Confusion (HP:0001289)2.62464001
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62130823
79Hypoglycemic coma (HP:0001325)2.61356613
80T lymphocytopenia (HP:0005403)2.61160644
81Metabolic acidosis (HP:0001942)2.56718048
82Peritonitis (HP:0002586)2.56345158
83Postural instability (HP:0002172)2.55605111
84Abnormality of T cell number (HP:0011839)2.55338738
85Osteomyelitis (HP:0002754)2.50763353
86Hyperammonemia (HP:0001987)2.47384128
87Visual hallucinations (HP:0002367)2.47110153
88Chest pain (HP:0100749)2.46264004
89Leukocytosis (HP:0001974)2.45894618
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.45282333
91Increased IgM level (HP:0003496)2.40707094
92Recurrent viral infections (HP:0004429)2.40187786
93Abnormality of T cells (HP:0002843)2.34520035
94Global brain atrophy (HP:0002283)2.34001808
95Ketosis (HP:0001946)2.31741144
96Hyponatremia (HP:0002902)2.28517646
97Arterial thrombosis (HP:0004420)2.25257891
98Rickets (HP:0002748)2.25196060
99Nonimmune hydrops fetalis (HP:0001790)2.21994652
100Hemorrhage of the eye (HP:0011885)2.21704008
101Epidermoid cyst (HP:0200040)2.21683795
102Hypertriglyceridemia (HP:0002155)2.21217080
103Pulmonary infiltrates (HP:0002113)2.19880420
104Panhypogammaglobulinemia (HP:0003139)2.19154790
105Severe visual impairment (HP:0001141)2.18764721
106Abnormality of the intrinsic pathway (HP:0010989)2.17676757
107Generalized hyperpigmentation (HP:0007440)2.17299059
108Fat malabsorption (HP:0002630)2.17191832
109Abnormality of the fingertips (HP:0001211)2.14279867
110Abnormality of pyrimidine metabolism (HP:0004353)2.12837666
111Abnormality of T cell physiology (HP:0011840)2.12729904
112Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12557397
113Autoimmune hemolytic anemia (HP:0001890)2.10829312
114Granulocytopenia (HP:0001913)2.10598892
115Lower limb hyperreflexia (HP:0002395)2.08027879
116Purpura (HP:0000979)2.07954573
117Hemoptysis (HP:0002105)2.07362995
118Renal tubular acidosis (HP:0001947)2.06412485
119Neoplasm of the liver (HP:0002896)2.04731969
120Pathologic fracture (HP:0002756)2.04403774
121Abnormality of sodium homeostasis (HP:0010931)2.04314168
122Epistaxis (HP:0000421)2.02250343
123Abnormality of methionine metabolism (HP:0010901)2.01215268
124Poikilocytosis (HP:0004447)12.6987934
125* Abnormality of the heme biosynthetic pathway (HP:0010472)10.0205051
126Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98046584
127Albinism (HP:0001022)1.97935749
128Autoimmune thrombocytopenia (HP:0001973)1.97725006
129Thrombophlebitis (HP:0004418)1.97002724
130Pulmonary embolism (HP:0002204)1.95635561
131Onycholysis (HP:0001806)1.95628928
132Prolonged bleeding time (HP:0003010)1.95319331
133Spontaneous abortion (HP:0005268)1.94743882
134Increased mean platelet volume (HP:0011877)1.93647792
135Dysautonomia (HP:0002459)1.93172488
136Hyperglycinemia (HP:0002154)1.92665586
137Systemic lupus erythematosus (HP:0002725)1.91664896
138Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91203971
139Colitis (HP:0002583)1.90546397
140Petechiae (HP:0000967)1.90385820
141Difficulty running (HP:0009046)1.89242915
142Abnormality of fatty-acid metabolism (HP:0004359)1.88884237
143Pustule (HP:0200039)1.88588221
144Recurrent gram-negative bacterial infections (HP:0005420)1.87501873
145Abnormality of serine family amino acid metabolism (HP:0010894)1.85904584
146Abnormality of glycine metabolism (HP:0010895)1.85904584
147Hypercholesterolemia (HP:0003124)1.85801590
148Nasal polyposis (HP:0100582)1.85579115
149* Hypochromic microcytic anemia (HP:0004840)1.82973315
150Acne (HP:0001061)1.82023896
151Pancreatic islet-cell hyperplasia (HP:0004510)1.81947658
152Abnormal platelet volume (HP:0011876)1.81765669
153Sepsis (HP:0100806)1.80476474
154Lymphopenia (HP:0001888)1.80419248
155Splenomegaly (HP:0001744)1.80399292
156Gingival bleeding (HP:0000225)1.79245391
157Orthostatic hypotension (HP:0001278)1.78395844
158Menorrhagia (HP:0000132)1.78362914
159Cortical dysplasia (HP:0002539)1.77776704
160Vomiting (HP:0002013)1.76955480
161Hyperglycinuria (HP:0003108)1.74330916
162Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71761813
163Abnormality of nucleobase metabolism (HP:0010932)1.71373661
164Back pain (HP:0003418)1.71369525
165Delusions (HP:0000746)1.71077741
166Myocardial infarction (HP:0001658)1.68293722
167Spastic diplegia (HP:0001264)1.63309796
168Steatorrhea (HP:0002570)1.62071960
169Abnormal number of erythroid precursors (HP:0012131)1.61778489
170Sensorimotor neuropathy (HP:0007141)1.59720240
171Hypertensive crisis (HP:0100735)1.58902907
172Abnormal platelet function (HP:0011869)1.57213076

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.37449024
2TLK14.32053443
3RIPK43.85929211
4STK43.48560130
5ZAK2.65000945
6CDK122.59691272
7IRAK42.58503090
8BRSK12.55894913
9BLK2.38704765
10FGR2.27172409
11CDC72.26919909
12STK102.17775248
13BCKDK2.13886103
14MAPK112.07700302
15PRPF4B2.06091160
16TRIB31.99904008
17FES1.91848747
18TNK21.89886580
19CSK1.85506016
20PIM11.83284656
21GRK61.81156355
22TGFBR21.78019813
23PKN21.65732318
24MAP3K11.63687869
25HCK1.60175299
26EEF2K1.52662675
27ZAP701.51117149
28DYRK31.49699609
29BTK1.44312475
30CLK11.41706188
31TRPM71.41393649
32ERN11.38504856
33EPHB11.35811985
34CDK61.34513202
35MAP3K81.33324610
36VRK11.32828175
37GRK51.31166965
38NEK21.30782228
39ERBB21.30484780
40MAP3K101.29340669
41KSR21.28092339
42TAOK31.27043857
43RPS6KA51.21927530
44JAK21.21610795
45BUB11.20299994
46NEK11.18548866
47MAPKAPK31.16671260
48TIE11.16668456
49JAK31.16447153
50AURKB1.15658190
51FGFR41.14090349
52CDK41.13668786
53PTK61.12471331
54PRKAA11.09564667
55AURKA1.09051141
56MAP2K31.08579971
57ABL21.06460884
58TXK1.06452610
59BRSK21.06086451
60MAP3K111.04273199
61MELK1.04052328
62PBK1.01580706
63NME21.01427529
64MAP3K51.00676596
65MARK20.98363611
66CAMK1D0.95880892
67DAPK20.92253284
68TYK20.91817321
69GRK70.91523655
70SYK0.90369351
71HIPK20.89567969
72SIK10.88894274
73STK110.87216110
74KSR10.85619748
75SCYL20.84332730
76CDK190.83441897
77YES10.82753364
78FLT30.81643189
79CDC42BPA0.80844301
80SGK30.80747866
81MAP2K40.80668629
82CDK90.79529716
83PRKD20.78465058
84LCK0.78025534
85PRKAA20.76337697
86MAP3K20.74980454
87STK30.73502529
88TEC0.72876677
89CHEK20.72503049
90TTK0.68521617
91STK380.68051575
92BMX0.68029934
93ITK0.67741060
94WNK10.67405062
95ICK0.67288880
96SIK30.67121803
97TAOK10.65900991
98DYRK1B0.65352387
99IKBKB0.64777676
100IKBKE0.64050981
101MAP3K60.63557808
102MAP2K10.63107580
103PTK2B0.59904467
104NEK90.59619327
105PRKACG0.58611941
106SGK20.58158925
107MAP3K70.57575062
108PDPK10.56873881
109MAP3K140.55928450
110IRAK20.55421741
111PLK10.54687809
112KDR0.53466519
113MAP3K30.53377525
114BMPR20.52976252
115IRAK10.52380556
116CHEK10.51048873
117PINK10.50095796
118SIK20.49768040
119STK240.49545867
120RPS6KC10.49163570
121RPS6KL10.49163570
122SGK4940.48882867
123SGK2230.48882867
124RAF10.48431334
125PKN10.48021250
126MAPKAPK20.47929527
127FYN0.47889413
128ATM0.47067158
129SMG10.46509764
130MAPK120.46040587
131KIT0.45665867
132DAPK30.44384541
133JAK10.44329634
134MAP4K10.43740209
135MAP3K130.43533230
136MATK0.42628913
137RPS6KA60.41811333
138TBK10.41664274
139PIK3CG0.41642674
140BRD40.41469473
141LRRK20.41455000
142CSNK1D0.40766442
143CSF1R0.40524753
144EIF2AK20.40262554
145PLK30.39982539
146LYN0.39588579
147RPS6KB20.38788686
148MARK30.37325721
149SGK10.34083069
150TTN0.33728655
151PRKCQ0.33375739
152DYRK1A0.32303561
153MOS0.31920830
154PDK10.29799644
155MTOR0.28956600
156CAMK1G0.26842477
157EGFR0.25834469
158CDK10.24916600
159TAOK20.23352217

Predicted pathways (KEGG)

RankGene SetZ-score
1* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.59013567
2Vitamin B6 metabolism_Homo sapiens_hsa007504.71109078
3Systemic lupus erythematosus_Homo sapiens_hsa053223.82320226
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.65537625
5Nitrogen metabolism_Homo sapiens_hsa009102.82967789
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.82136078
7Osteoclast differentiation_Homo sapiens_hsa043802.81565686
8Complement and coagulation cascades_Homo sapiens_hsa046102.59853561
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46481507
10Leishmaniasis_Homo sapiens_hsa051402.44654232
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33541603
12* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33256150
13Tryptophan metabolism_Homo sapiens_hsa003802.30122320
14Arginine biosynthesis_Homo sapiens_hsa002202.27058758
15Fatty acid degradation_Homo sapiens_hsa000712.22276361
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.22203691
17B cell receptor signaling pathway_Homo sapiens_hsa046622.20293506
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.11845166
19Acute myeloid leukemia_Homo sapiens_hsa052211.99206581
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95866570
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.92616178
22Tuberculosis_Homo sapiens_hsa051521.91251817
23Selenocompound metabolism_Homo sapiens_hsa004501.87385222
24ABC transporters_Homo sapiens_hsa020101.86211899
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83427059
26Pancreatic cancer_Homo sapiens_hsa052121.81889004
27Primary immunodeficiency_Homo sapiens_hsa053401.76048983
28African trypanosomiasis_Homo sapiens_hsa051431.74374431
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.72049301
30Measles_Homo sapiens_hsa051621.71614437
31T cell receptor signaling pathway_Homo sapiens_hsa046601.65842175
32Chemokine signaling pathway_Homo sapiens_hsa040621.61197073
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60705926
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59405532
35Alcoholism_Homo sapiens_hsa050341.57355882
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.56964046
37PPAR signaling pathway_Homo sapiens_hsa033201.54970030
38Sulfur relay system_Homo sapiens_hsa041221.52394398
39Toxoplasmosis_Homo sapiens_hsa051451.49960034
40Propanoate metabolism_Homo sapiens_hsa006401.49697268
41Butanoate metabolism_Homo sapiens_hsa006501.49063373
42Pyruvate metabolism_Homo sapiens_hsa006201.48632972
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.48544879
44Caffeine metabolism_Homo sapiens_hsa002321.46162213
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42753262
46Fatty acid metabolism_Homo sapiens_hsa012121.42624119
47Peroxisome_Homo sapiens_hsa041461.41362598
48beta-Alanine metabolism_Homo sapiens_hsa004101.38783799
49Staphylococcus aureus infection_Homo sapiens_hsa051501.36354485
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36045170
51Influenza A_Homo sapiens_hsa051641.32224684
52Herpes simplex infection_Homo sapiens_hsa051681.29577221
53Bile secretion_Homo sapiens_hsa049761.25889629
54Chemical carcinogenesis_Homo sapiens_hsa052041.25523760
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23851570
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.22295192
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.18401374
58One carbon pool by folate_Homo sapiens_hsa006701.17227223
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17181069
60Phenylalanine metabolism_Homo sapiens_hsa003601.16983210
61Histidine metabolism_Homo sapiens_hsa003401.16450021
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16446589
63Graft-versus-host disease_Homo sapiens_hsa053321.15865252
64Hepatitis B_Homo sapiens_hsa051611.15757871
65Carbon metabolism_Homo sapiens_hsa012001.15274849
66Renal cell carcinoma_Homo sapiens_hsa052111.14930582
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14585012
68VEGF signaling pathway_Homo sapiens_hsa043701.14430900
69Leukocyte transendothelial migration_Homo sapiens_hsa046701.14334900
70Platelet activation_Homo sapiens_hsa046111.14230369
71TNF signaling pathway_Homo sapiens_hsa046681.12856596
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12385082
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11459551
74Biosynthesis of amino acids_Homo sapiens_hsa012301.11030512
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08280445
76Legionellosis_Homo sapiens_hsa051341.08019333
77Phagosome_Homo sapiens_hsa041451.07088569
78Glutathione metabolism_Homo sapiens_hsa004801.04836615
79Allograft rejection_Homo sapiens_hsa053301.04599905
80Tyrosine metabolism_Homo sapiens_hsa003501.03833424
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03633642
82Endometrial cancer_Homo sapiens_hsa052131.02291538
83Fat digestion and absorption_Homo sapiens_hsa049751.00973318
84Autoimmune thyroid disease_Homo sapiens_hsa053200.98677021
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98163292
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.96150928
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92988196
88Prolactin signaling pathway_Homo sapiens_hsa049170.92389533
89Lysine degradation_Homo sapiens_hsa003100.89489444
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88222478
91Folate biosynthesis_Homo sapiens_hsa007900.87274510
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.86310344
93Inositol phosphate metabolism_Homo sapiens_hsa005620.86176878
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86174864
95Retinol metabolism_Homo sapiens_hsa008300.85912439
96Choline metabolism in cancer_Homo sapiens_hsa052310.85475370
97mTOR signaling pathway_Homo sapiens_hsa041500.85219574
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83739110
99Sulfur metabolism_Homo sapiens_hsa009200.80806713
100Endocytosis_Homo sapiens_hsa041440.80760965
101Salmonella infection_Homo sapiens_hsa051320.80702945
102Antigen processing and presentation_Homo sapiens_hsa046120.80566346
103Shigellosis_Homo sapiens_hsa051310.79537925
104Malaria_Homo sapiens_hsa051440.77413380
105Cell cycle_Homo sapiens_hsa041100.76110053
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75628525
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.75184375
108Starch and sucrose metabolism_Homo sapiens_hsa005000.75032946
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74128671
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.73896692
111Fatty acid elongation_Homo sapiens_hsa000620.73891909
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72432594
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71877074
114HIF-1 signaling pathway_Homo sapiens_hsa040660.70976450
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.70873660
116Thyroid cancer_Homo sapiens_hsa052160.70850650
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70180876
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69510453
119Notch signaling pathway_Homo sapiens_hsa043300.67920097
120DNA replication_Homo sapiens_hsa030300.67154448
121Glioma_Homo sapiens_hsa052140.66399911
122Viral carcinogenesis_Homo sapiens_hsa052030.66105319
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.64843373
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64106092
125Arginine and proline metabolism_Homo sapiens_hsa003300.63504601
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62432035
127GnRH signaling pathway_Homo sapiens_hsa049120.61509985
128Bladder cancer_Homo sapiens_hsa052190.61107344
129Pentose phosphate pathway_Homo sapiens_hsa000300.60391596
130Type I diabetes mellitus_Homo sapiens_hsa049400.59209230
131Colorectal cancer_Homo sapiens_hsa052100.58847739
132Epstein-Barr virus infection_Homo sapiens_hsa051690.58834385
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55915322
134MAPK signaling pathway_Homo sapiens_hsa040100.55485123
135Prostate cancer_Homo sapiens_hsa052150.54016634
136Vitamin digestion and absorption_Homo sapiens_hsa049770.53835541
137HTLV-I infection_Homo sapiens_hsa051660.53668609
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53285828
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53125114
140Viral myocarditis_Homo sapiens_hsa054160.52026014
141Steroid biosynthesis_Homo sapiens_hsa001000.51274856
142ErbB signaling pathway_Homo sapiens_hsa040120.50925897
143Type II diabetes mellitus_Homo sapiens_hsa049300.50795589
144Pertussis_Homo sapiens_hsa051330.50567520
145Hematopoietic cell lineage_Homo sapiens_hsa046400.49430877
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.46330184
147Other glycan degradation_Homo sapiens_hsa005110.45362152
148Long-term potentiation_Homo sapiens_hsa047200.43893485
149AMPK signaling pathway_Homo sapiens_hsa041520.42191420
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.42111900
151* Metabolic pathways_Homo sapiens_hsa011000.40029860
152Non-small cell lung cancer_Homo sapiens_hsa052230.38985723
153Insulin resistance_Homo sapiens_hsa049310.38532454
154Glycerolipid metabolism_Homo sapiens_hsa005610.33870387
155p53 signaling pathway_Homo sapiens_hsa041150.23192556
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22546177
157Prion diseases_Homo sapiens_hsa050200.21703195
158Apoptosis_Homo sapiens_hsa042100.17256171
159Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16267454
160Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15435615
161Collecting duct acid secretion_Homo sapiens_hsa049660.14923313
162Fructose and mannose metabolism_Homo sapiens_hsa000510.14700335
163Fatty acid biosynthesis_Homo sapiens_hsa000610.13084952
164Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12844939
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12177193
166Small cell lung cancer_Homo sapiens_hsa052220.11237296
167Glucagon signaling pathway_Homo sapiens_hsa049220.11081685
168Chronic myeloid leukemia_Homo sapiens_hsa052200.10634027
169Dorso-ventral axis formation_Homo sapiens_hsa043200.09434030
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09342482
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.08210816
172FoxO signaling pathway_Homo sapiens_hsa040680.06398393
173Regulation of autophagy_Homo sapiens_hsa041400.05858365
174Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.04986310
175Insulin signaling pathway_Homo sapiens_hsa049100.04805561
176Hepatitis C_Homo sapiens_hsa051600.02120560

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