ALB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.88345839
2L-phenylalanine catabolic process (GO:0006559)7.61800569
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61800569
4L-phenylalanine metabolic process (GO:0006558)7.28102948
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28102948
6aromatic amino acid family catabolic process (GO:0009074)6.85221537
7epoxygenase P450 pathway (GO:0019373)6.81946495
8omega-hydroxylase P450 pathway (GO:0097267)6.51171610
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.42309261
10tryptophan catabolic process (GO:0006569)6.17492142
11indole-containing compound catabolic process (GO:0042436)6.17492142
12indolalkylamine catabolic process (GO:0046218)6.17492142
13kynurenine metabolic process (GO:0070189)6.06694359
14bile acid biosynthetic process (GO:0006699)5.99651077
15tryptophan metabolic process (GO:0006568)5.81382505
16glyoxylate metabolic process (GO:0046487)5.79229609
17urea metabolic process (GO:0019627)5.74178821
18urea cycle (GO:0000050)5.74178821
19negative regulation of fibrinolysis (GO:0051918)5.71142615
20regulation of plasminogen activation (GO:0010755)5.70537718
21alpha-linolenic acid metabolic process (GO:0036109)5.67314528
22high-density lipoprotein particle remodeling (GO:0034375)5.66233465
23intestinal cholesterol absorption (GO:0030299)5.60130899
24regulation of fibrinolysis (GO:0051917)5.50111346
25peptidyl-glutamic acid carboxylation (GO:0017187)5.41859658
26protein carboxylation (GO:0018214)5.41859658
27complement activation, alternative pathway (GO:0006957)5.39766759
28regulation of protein activation cascade (GO:2000257)5.38658490
29cysteine metabolic process (GO:0006534)5.37031194
30sulfur amino acid catabolic process (GO:0000098)5.36991099
31nitrogen cycle metabolic process (GO:0071941)5.27799406
32serine family amino acid catabolic process (GO:0009071)5.14037374
33regulation of complement activation (GO:0030449)5.02409386
34negative regulation of blood coagulation (GO:0030195)4.99656790
35negative regulation of hemostasis (GO:1900047)4.99656790
36aromatic amino acid family metabolic process (GO:0009072)4.97886958
37* bile acid metabolic process (GO:0008206)4.97580480
38negative regulation of protein activation cascade (GO:2000258)4.96039128
39regulation of cholesterol esterification (GO:0010872)4.95747676
40reverse cholesterol transport (GO:0043691)4.95418725
41ethanol metabolic process (GO:0006067)4.90540547
42regulation of triglyceride catabolic process (GO:0010896)4.89942958
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89562853
44drug metabolic process (GO:0017144)4.89311262
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.88208930
46plasma lipoprotein particle remodeling (GO:0034369)4.85399773
47protein-lipid complex remodeling (GO:0034368)4.85399773
48macromolecular complex remodeling (GO:0034367)4.85399773
49tyrosine metabolic process (GO:0006570)4.84306718
50homocysteine metabolic process (GO:0050667)4.81309076
51regulation of humoral immune response (GO:0002920)4.70580138
52acute-phase response (GO:0006953)4.67820178
53alpha-amino acid catabolic process (GO:1901606)4.66578989
54acylglycerol homeostasis (GO:0055090)4.66140216
55triglyceride homeostasis (GO:0070328)4.66140216
56phospholipid efflux (GO:0033700)4.65903321
57regulation of apoptotic cell clearance (GO:2000425)4.65427244
58amino-acid betaine metabolic process (GO:0006577)4.63826125
59negative regulation of cholesterol transport (GO:0032375)4.61459785
60negative regulation of sterol transport (GO:0032372)4.61459785
61lysine metabolic process (GO:0006553)4.60319429
62lysine catabolic process (GO:0006554)4.60319429
63negative regulation of coagulation (GO:0050819)4.57336903
64positive regulation of hemostasis (GO:1900048)4.53524535
65positive regulation of blood coagulation (GO:0030194)4.53524535
66cellular ketone body metabolic process (GO:0046950)4.48841488
67oxidative demethylation (GO:0070989)4.47043531
68plasma lipoprotein particle clearance (GO:0034381)4.46196148
69glycine metabolic process (GO:0006544)4.44690711
70negative regulation of wound healing (GO:0061045)4.44501945
71coenzyme catabolic process (GO:0009109)4.38667711
72indolalkylamine metabolic process (GO:0006586)4.37607670
73imidazole-containing compound metabolic process (GO:0052803)4.36104626
74cholesterol efflux (GO:0033344)4.29273292
75cellular amino acid catabolic process (GO:0009063)4.28958511
76cellular glucuronidation (GO:0052695)4.28871122
77cellular biogenic amine catabolic process (GO:0042402)4.28341347
78amine catabolic process (GO:0009310)4.28341347
79glutamate metabolic process (GO:0006536)4.26671542
80serine family amino acid metabolic process (GO:0009069)4.19833138
81positive regulation of coagulation (GO:0050820)4.16027572
82* bile acid and bile salt transport (GO:0015721)4.13204224
83benzene-containing compound metabolic process (GO:0042537)4.12458423
84ethanol oxidation (GO:0006069)4.11282263
85plasma lipoprotein particle assembly (GO:0034377)4.07702944
86low-density lipoprotein particle remodeling (GO:0034374)4.07545689
87cellular modified amino acid catabolic process (GO:0042219)4.07460249
88dicarboxylic acid biosynthetic process (GO:0043650)4.07284667
89arginine metabolic process (GO:0006525)4.06531653
90fibrinolysis (GO:0042730)4.05930442
91serine family amino acid biosynthetic process (GO:0009070)4.02616065
92aldehyde catabolic process (GO:0046185)4.01068237
93protein-lipid complex subunit organization (GO:0071825)3.98323588
94daunorubicin metabolic process (GO:0044597)3.96159695
95polyketide metabolic process (GO:0030638)3.96159695
96doxorubicin metabolic process (GO:0044598)3.96159695
97phenylpropanoid metabolic process (GO:0009698)3.94619799
98blood coagulation, intrinsic pathway (GO:0007597)3.91822713
99drug catabolic process (GO:0042737)3.91189749
100S-adenosylmethionine metabolic process (GO:0046500)3.89816337
101ketone body metabolic process (GO:1902224)3.88616975
102negative regulation of complement activation (GO:0045916)3.86298355
103positive regulation of lipoprotein lipase activity (GO:0051006)3.83829296
104positive regulation of triglyceride lipase activity (GO:0061365)3.83829296
105cofactor catabolic process (GO:0051187)3.82018685
106phospholipid homeostasis (GO:0055091)3.81492841
107uronic acid metabolic process (GO:0006063)3.80325070
108glucuronate metabolic process (GO:0019585)3.80325070
109positive regulation of lipid catabolic process (GO:0050996)3.80197188
110negative regulation of lipase activity (GO:0060192)3.79914542
111very-low-density lipoprotein particle assembly (GO:0034379)3.79681855
112complement activation, classical pathway (GO:0006958)3.78719354
113cholesterol homeostasis (GO:0042632)3.77435734
114complement activation (GO:0006956)3.75446692
115protein activation cascade (GO:0072376)3.75376527
116organic acid catabolic process (GO:0016054)3.75231170
117carboxylic acid catabolic process (GO:0046395)3.75231170
118regulation of bile acid biosynthetic process (GO:0070857)3.71381318
119sterol homeostasis (GO:0055092)3.71168543
120plasma lipoprotein particle organization (GO:0071827)3.68712766
121acetyl-CoA metabolic process (GO:0006084)3.68172502
122short-chain fatty acid metabolic process (GO:0046459)3.65787473
123protein-lipid complex assembly (GO:0065005)3.65663117
124regulation of cholesterol homeostasis (GO:2000188)3.63751873
125fat-soluble vitamin biosynthetic process (GO:0042362)3.63244198
126flavonoid metabolic process (GO:0009812)3.58873991
127NAD biosynthetic process (GO:0009435)3.55856348
128pyridine nucleotide biosynthetic process (GO:0019363)3.53708073
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.53708073
130aminoglycoside antibiotic metabolic process (GO:0030647)3.50923475
131opsonization (GO:0008228)3.49680498
132acute inflammatory response (GO:0002526)3.45533447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42336583
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19830391
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.00069758
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50712573
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31598867
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14025891
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85660033
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05809376
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03008032
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08813350
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0195903
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98488398
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97560376
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.61603643
15HTT_18923047_ChIP-ChIP_STHdh_Human1.57814793
16CLOCK_20551151_ChIP-Seq_293T_Human1.56499450
17GATA1_22025678_ChIP-Seq_K562_Human1.46021875
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40080358
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28110974
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24819394
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19737009
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19643290
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.17089522
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16941395
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09372332
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.07991403
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01153313
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00638773
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97658927
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93363757
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91563546
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90544993
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90250683
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84982742
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83641814
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82955407
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82519245
38IRF8_22096565_ChIP-ChIP_GC-B_Human0.82186735
39RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82084085
40GATA4_25053715_ChIP-Seq_YYC3_Human0.80043743
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79007489
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78392411
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75732829
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75619282
45ZNF263_19887448_ChIP-Seq_K562_Human0.75039966
46SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74760423
47SOX2_20726797_ChIP-Seq_SW620_Human0.73628594
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73378432
49* RARA_24833708_ChIP-Seq_LIVER_Mouse0.71421493
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70680907
51TP63_17297297_ChIP-ChIP_HaCaT_Human0.70635735
52POU5F1_16518401_ChIP-PET_MESCs_Mouse0.69154946
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67527708
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67371825
55CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65021833
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64974627
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64974627
58ESR2_21235772_ChIP-Seq_MCF-7_Human0.64743300
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64586357
60NFIB_24661679_ChIP-Seq_LUNG_Mouse0.64272239
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63374745
62RARB_24833708_ChIP-Seq_LIVER_Mouse0.63145582
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61573538
64AR_21909140_ChIP-Seq_LNCAP_Human0.61399636
65RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60643870
66SOX2_21211035_ChIP-Seq_LN229_Human0.60430670
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59922918
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59498380
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59461170
70HIF1A_21447827_ChIP-Seq_MCF-7_Human0.59021593
71PCGF2_27294783_Chip-Seq_NPCs_Mouse0.59008819
72NFE2_27457419_Chip-Seq_LIVER_Mouse0.58599609
73GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.55739959
74SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55312814
75EGR1_19032775_ChIP-ChIP_M12_Human0.54709357
76* CEBPB_22108803_ChIP-Seq_LS180_Human0.54690325
77RAC3_21632823_ChIP-Seq_H3396_Human0.53926797
78TP53_18474530_ChIP-ChIP_U2OS_Human0.52793933
79LXR_22292898_ChIP-Seq_THP-1_Human0.52272060
80AR_20517297_ChIP-Seq_VCAP_Human0.51620841
81DNAJC2_21179169_ChIP-ChIP_NT2_Human0.51500569
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51491466
83STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51236595
84MYC_19915707_ChIP-ChIP_AK7_Human0.50944730
85FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50868541
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50767906
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50535563
88* FOXA1_25552417_ChIP-Seq_VCAP_Human0.50256758
89ESRRB_18555785_Chip-Seq_ESCs_Mouse0.48581867
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.48571045
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48503086
92ESET_19884257_ChIP-Seq_ESCs_Mouse0.48366844
93GATA3_24758297_ChIP-Seq_MCF-7_Human0.48310003
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.48233535
95CBP_21632823_ChIP-Seq_H3396_Human0.48192463
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.47208560
97STAT1_17558387_ChIP-Seq_HELA_Human0.46919774
98P53_21459846_ChIP-Seq_SAOS-2_Human0.46605874
99SMC4_20622854_ChIP-Seq_HELA_Human0.46165577
100TAF15_26573619_Chip-Seq_HEK293_Human0.45857964
101PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45787291
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45236486
103OCT4_18555785_Chip-Seq_ESCs_Mouse0.45083028
104CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44441354
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44077069
106GATA1_19941826_ChIP-Seq_K562_Human0.43947253
107RUNX1_27457419_Chip-Seq_LIVER_Mouse0.43513664
108NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.43263051
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.43215148
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.42943953
111PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42360204
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.42279591
113TAF2_19829295_ChIP-Seq_ESCs_Human0.41440787
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41375786
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.41326598
116GATA2_19941826_ChIP-Seq_K562_Human0.40648880
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40052119
118ERG_21242973_ChIP-ChIP_JURKAT_Human0.39510033
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39481064
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39228357
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.39157503
122BCAT_22108803_ChIP-Seq_LS180_Human0.38768160
123GATA6_25053715_ChIP-Seq_YYC3_Human0.38428892
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37780602
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.37044445
126LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35682668
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34765601
128NCOR_22424771_ChIP-Seq_293T_Human0.33917342
129ERG_20517297_ChIP-Seq_VCAP_Human0.33788025
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33327257
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.33200135
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.32746535
133CDX2_22108803_ChIP-Seq_LS180_Human0.32447633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.40983413
2MP0005360_urolithiasis7.57689694
3MP0005085_abnormal_gallbladder_physiolo6.52484106
4* MP0005365_abnormal_bile_salt5.95342170
5MP0008875_abnormal_xenobiotic_pharmacok5.18456000
6MP0003806_abnormal_nucleotide_metabolis4.29338670
7MP0003252_abnormal_bile_duct3.95024573
8MP0010329_abnormal_lipoprotein_level3.64327862
9MP0009840_abnormal_foam_cell3.36129992
10MP0005083_abnormal_biliary_tract3.13167971
11MP0003195_calcinosis2.82009117
12MP0005332_abnormal_amino_acid2.77138849
13MP0003191_abnormal_cellular_cholesterol2.37147725
14* MP0001666_abnormal_nutrient_absorption2.36073745
15* MP0000609_abnormal_liver_physiology2.16470900
16MP0004019_abnormal_vitamin_homeostasis2.14340668
17* MP0002118_abnormal_lipid_homeostasis2.09665900
18MP0002138_abnormal_hepatobiliary_system1.98238534
19MP0005319_abnormal_enzyme/_coenzyme1.84679710
20MP0001764_abnormal_homeostasis1.69155152
21MP0009697_abnormal_copulation1.63339373
22MP0005584_abnormal_enzyme/coenzyme_acti1.59020900
23MP0003122_maternal_imprinting1.56271659
24MP0005451_abnormal_body_composition1.46422867
25MP0003011_delayed_dark_adaptation1.45144686
26* MP0003868_abnormal_feces_composition1.44574131
27MP0001915_intracranial_hemorrhage1.34736549
28MP0000566_synostosis1.32384068
29MP0003656_abnormal_erythrocyte_physiolo1.31065084
30MP0003186_abnormal_redox_activity1.28473296
31MP0000598_abnormal_liver_morphology1.19752080
32* MP0009643_abnormal_urine_homeostasis1.17414419
33MP0003705_abnormal_hypodermis_morpholog1.16764652
34MP0005647_abnormal_sex_gland1.14668693
35MP0000604_amyloidosis1.10712407
36MP0009764_decreased_sensitivity_to1.06328749
37MP0002254_reproductive_system_inflammat1.03976505
38MP0009763_increased_sensitivity_to1.03389832
39MP0005058_abnormal_lysosome_morphology0.97535168
40MP0010368_abnormal_lymphatic_system0.97343344
41MP0002089_abnormal_postnatal_growth/wei0.93132790
42MP0008469_abnormal_protein_level0.89721031
43* MP0009642_abnormal_blood_homeostasis0.86799977
44MP0005408_hypopigmentation0.86131543
45* MP0005636_abnormal_mineral_homeostasis0.83550750
46MP0006036_abnormal_mitochondrial_physio0.83252854
47MP0005376_homeostasis/metabolism_phenot0.80842876
48MP0005670_abnormal_white_adipose0.79387049
49MP0009765_abnormal_xenobiotic_induced0.79335139
50MP0002078_abnormal_glucose_homeostasis0.78631940
51MP0005084_abnormal_gallbladder_morpholo0.76597389
52MP0002876_abnormal_thyroid_physiology0.76384752
53MP0003879_abnormal_hair_cell0.74630365
54MP0005220_abnormal_exocrine_pancreas0.72791737
55MP0002971_abnormal_brown_adipose0.72352351
56MP0002282_abnormal_trachea_morphology0.70774263
57MP0004130_abnormal_muscle_cell0.70343599
58MP0003123_paternal_imprinting0.70097233
59MP0005334_abnormal_fat_pad0.69756878
60MP0003690_abnormal_glial_cell0.69537914
61MP0001661_extended_life_span0.68055647
62MP0005535_abnormal_body_temperature0.67635249
63MP0009053_abnormal_anal_canal0.67169738
64MP0005266_abnormal_metabolism0.65506304
65MP0005023_abnormal_wound_healing0.65393828
66MP0003329_amyloid_beta_deposits0.64922359
67MP0003172_abnormal_lysosome_physiology0.64542985
68MP0000639_abnormal_adrenal_gland0.62504507
69MP0005409_darkened_coat_color0.58715811
70MP0006035_abnormal_mitochondrial_morpho0.58513381
71MP0005448_abnormal_energy_balance0.55999398
72MP0004272_abnormal_basement_membrane0.54696883
73MP0005464_abnormal_platelet_physiology0.54558083
74MP0002822_catalepsy0.50074313
75MP0009780_abnormal_chondrocyte_physiolo0.49650098
76MP0005395_other_phenotype0.48435180
77MP0003638_abnormal_response/metabolism_0.46458516
78MP0003718_maternal_effect0.46426751
79MP0008874_decreased_physiological_sensi0.46163159
80MP0008873_increased_physiological_sensi0.45586977
81MP0002928_abnormal_bile_duct0.45453455
82MP0005187_abnormal_penis_morphology0.44769561
83MP0002249_abnormal_larynx_morphology0.44094981
84MP0004782_abnormal_surfactant_physiolog0.43381797
85* MP0001756_abnormal_urination0.43053738
86MP0003436_decreased_susceptibility_to0.42821318
87MP0003632_abnormal_nervous_system0.42257114
88MP0002837_dystrophic_cardiac_calcinosis0.41857979
89MP0003724_increased_susceptibility_to0.41676449
90MP0003075_altered_response_to0.41616602
91MP0000920_abnormal_myelination0.41252792
92MP0005248_abnormal_Harderian_gland0.40829251
93MP0003953_abnormal_hormone_level0.40789369
94MP0004381_abnormal_hair_follicle0.39746039
95* MP0002136_abnormal_kidney_physiology0.39739636
96MP0008872_abnormal_physiological_respon0.38614304
97MP0005166_decreased_susceptibility_to0.38337288
98MP0009672_abnormal_birth_weight0.37702625
99MP0005666_abnormal_adipose_tissue0.37572512
100MP0005377_hearing/vestibular/ear_phenot0.35512247
101MP0003878_abnormal_ear_physiology0.35512247
102MP0005167_abnormal_blood-brain_barrier0.35461664
103MP0002909_abnormal_adrenal_gland0.35334697
104MP0005257_abnormal_intraocular_pressure0.35006504
105MP0000579_abnormal_nail_morphology0.34574390
106MP0002796_impaired_skin_barrier0.33768481
107MP0009115_abnormal_fat_cell0.33360937
108MP0001243_abnormal_dermal_layer0.32922553
109MP0000249_abnormal_blood_vessel0.32740722
110MP0004883_abnormal_blood_vessel0.32448932
111MP0003566_abnormal_cell_adhesion0.32089285
112MP0006082_CNS_inflammation0.31585081
113MP0000230_abnormal_systemic_arterial0.31430186
114MP0002933_joint_inflammation0.31024758
115MP0009384_cardiac_valve_regurgitation0.30934708
116MP0002970_abnormal_white_adipose0.30875616
117MP0000858_altered_metastatic_potential0.30461130
118MP0001853_heart_inflammation0.30313074
119MP0002168_other_aberrant_phenotype0.30240829
120MP0003943_abnormal_hepatobiliary_system0.30201225
121MP0002128_abnormal_blood_circulation0.28661395
122MP0001845_abnormal_inflammatory_respons0.28284812
123MP0001881_abnormal_mammary_gland0.28238998
124MP0006054_spinal_hemorrhage0.27543261
125MP0003183_abnormal_peptide_metabolism0.27473740
126MP0003950_abnormal_plasma_membrane0.25732645
127MP0005164_abnormal_response_to0.25631607
128MP0003631_nervous_system_phenotype0.25589973
129MP0002090_abnormal_vision0.25290636
130MP0002132_abnormal_respiratory_system0.24471979
131MP0002060_abnormal_skin_morphology0.24071325

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.50376788
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41068147
3Intrahepatic cholestasis (HP:0001406)7.31992951
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.71088133
5Prolonged partial thromboplastin time (HP:0003645)6.63291625
6Hypobetalipoproteinemia (HP:0003563)6.49872796
7Xanthomatosis (HP:0000991)6.31701437
8Hyperlipoproteinemia (HP:0010980)5.61618413
9Complement deficiency (HP:0004431)5.40874720
10Hypolipoproteinemia (HP:0010981)4.86435617
11Joint hemorrhage (HP:0005261)4.83305867
12Hyperammonemia (HP:0001987)4.61692797
13Epidermoid cyst (HP:0200040)4.54892573
14Abnormality of the common coagulation pathway (HP:0010990)4.49765702
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45014149
16Hyperglycinemia (HP:0002154)4.40594284
17Abnormality of methionine metabolism (HP:0010901)4.32023941
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.24883009
19Hypoalphalipoproteinemia (HP:0003233)4.24466153
20Ketosis (HP:0001946)4.22935798
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13483418
22Fat malabsorption (HP:0002630)4.13245342
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12413311
24Abnormality of complement system (HP:0005339)3.94679219
25Abnormality of serine family amino acid metabolism (HP:0010894)3.88568988
26Abnormality of glycine metabolism (HP:0010895)3.88568988
27Hyperglycinuria (HP:0003108)3.87930149
28Hypoglycemic coma (HP:0001325)3.86275123
29Abnormality of pyrimidine metabolism (HP:0004353)3.86166824
30Abnormality of the intrinsic pathway (HP:0010989)3.79369416
31Conjugated hyperbilirubinemia (HP:0002908)3.71776295
32Hypercholesterolemia (HP:0003124)3.65240942
33Hyperbilirubinemia (HP:0002904)3.36990888
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36700492
35Abnormality of fatty-acid metabolism (HP:0004359)3.32262671
36Steatorrhea (HP:0002570)3.11384320
37Delayed CNS myelination (HP:0002188)3.08275803
38Abnormality of serum amino acid levels (HP:0003112)3.07583966
39Spontaneous abortion (HP:0005268)3.05794894
40Abnormality of nucleobase metabolism (HP:0010932)3.04553028
41Hypochromic microcytic anemia (HP:0004840)3.03009213
42Purpura (HP:0000979)3.02720949
43Hepatocellular carcinoma (HP:0001402)2.99792590
44Ketoacidosis (HP:0001993)2.98187020
45Myocardial infarction (HP:0001658)2.93457194
46Skin nodule (HP:0200036)2.81389907
47Metabolic acidosis (HP:0001942)2.75102080
48Systemic lupus erythematosus (HP:0002725)2.73475198
49Osteomalacia (HP:0002749)2.67522557
50Acanthocytosis (HP:0001927)2.64986305
51Abnormality of purine metabolism (HP:0004352)2.63746131
52Lethargy (HP:0001254)2.59541480
53Dicarboxylic aciduria (HP:0003215)2.55880139
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55880139
55Vascular calcification (HP:0004934)2.55218830
56Abnormal gallbladder morphology (HP:0012437)2.51488153
57Hypoglycemic seizures (HP:0002173)2.48338852
58Glomerulonephritis (HP:0000099)2.47866497
59Spastic diplegia (HP:0001264)2.47122490
60Abnormal gallbladder physiology (HP:0012438)2.45290382
61Cholecystitis (HP:0001082)2.45290382
62Cholelithiasis (HP:0001081)2.45082694
63Cerebral edema (HP:0002181)2.42740067
64Mitral stenosis (HP:0001718)2.40247441
65Gout (HP:0001997)2.39048980
66Recurrent gram-negative bacterial infections (HP:0005420)2.37038141
67Irritability (HP:0000737)2.35081954
68Neonatal onset (HP:0003623)2.34823002
69Amyloidosis (HP:0011034)2.32219656
70Arthropathy (HP:0003040)2.26489819
71Cardiovascular calcification (HP:0011915)2.26209285
72Gingival bleeding (HP:0000225)2.24012252
73Malnutrition (HP:0004395)2.23559345
74Esophageal varix (HP:0002040)2.22170039
75Pulmonary embolism (HP:0002204)2.19070619
76Menorrhagia (HP:0000132)2.16343329
77Pancreatitis (HP:0001733)2.12948553
78Sensorimotor neuropathy (HP:0007141)2.12919187
79Brushfield spots (HP:0001088)2.12509314
80Late onset (HP:0003584)2.11136795
81Thrombophlebitis (HP:0004418)2.10081969
82Abnormal tarsal ossification (HP:0008369)2.09522042
83Enlarged kidneys (HP:0000105)2.09140733
84Poikilocytosis (HP:0004447)2.08122230
85Bifid scrotum (HP:0000048)2.07710749
86Abnormality of the Achilles tendon (HP:0005109)2.05663365
87Vomiting (HP:0002013)2.05279773
88Abnormality of the gallbladder (HP:0005264)2.03712751
89Joint swelling (HP:0001386)2.01579962
90Opisthotonus (HP:0002179)2.01114203
91Hyperinsulinemic hypoglycemia (HP:0000825)2.01076939
92Generalized aminoaciduria (HP:0002909)2.00616562
93Hemorrhage of the eye (HP:0011885)1.99490246
94Fair hair (HP:0002286)1.93964537
95Abnormality of carpal bone ossification (HP:0006257)1.93870032
96Rickets (HP:0002748)1.93539984
97Increased serum pyruvate (HP:0003542)1.91654819
98Abnormality of iron homeostasis (HP:0011031)1.89854454
99Abnormal cartilage morphology (HP:0002763)1.88804678
100Abnormality of transition element cation homeostasis (HP:0011030)1.86878525
101Renal cortical cysts (HP:0000803)1.85383127
102Hypophosphatemic rickets (HP:0004912)1.83154503
103Hydroxyprolinuria (HP:0003080)1.81892505
104Abnormality of proline metabolism (HP:0010907)1.81892505
105Hyperphosphaturia (HP:0003109)1.81141717
106Epistaxis (HP:0000421)1.80946058
107Elevated hepatic transaminases (HP:0002910)1.80331298
108Abnormal enzyme/coenzyme activity (HP:0012379)1.80268364
109Alkalosis (HP:0001948)1.79976809
110Abnormal delivery (HP:0001787)1.79604761
111Status epilepticus (HP:0002133)1.78784820
112Nephritis (HP:0000123)1.75517638
113Abnormality of vitamin metabolism (HP:0100508)1.73562009
114Hyperglycemia (HP:0003074)1.73190718
115Glycosuria (HP:0003076)1.72853025
116Abnormality of urine glucose concentration (HP:0011016)1.72853025
117Increased mean platelet volume (HP:0011877)1.70547956
118Abnormality of glycolysis (HP:0004366)1.69929844
119Facial shape deformation (HP:0011334)1.68952280
120Potter facies (HP:0002009)1.68952280
121Gangrene (HP:0100758)1.65011287
122Reduced antithrombin III activity (HP:0001976)1.64300681
123Flat acetabular roof (HP:0003180)1.64073884
124Elevated alkaline phosphatase (HP:0003155)1.59998963
125Increased serum ferritin (HP:0003281)1.59954372
126Hypochromic anemia (HP:0001931)1.54396186
127Abnormal urine phosphate concentration (HP:0012599)1.52070880
128Pancreatic islet-cell hyperplasia (HP:0004510)1.50776572
129Abnormal platelet volume (HP:0011876)1.50545855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18983240
2FGFR44.59590390
3SIK14.57516171
4ERN14.36100513
5TAOK33.09682441
6INSRR2.98483692
7ERBB42.92146474
8PIK3CA2.42529489
9MAP2K42.38336244
10PKN22.30560812
11CDK122.25245429
12WNK42.18346918
13MST1R2.13302648
14FLT31.96888864
15MAPK111.90488285
16PDGFRA1.87686212
17PIK3CG1.80331846
18TRIB31.78737343
19FGFR11.77661562
20TYK21.70623792
21LATS11.67485022
22MAP3K21.59815548
23DAPK21.53512267
24ABL21.51537754
25TYRO31.47603908
26PTK61.46387269
27NEK91.42549584
28AKT31.41135409
29FGFR21.39937934
30FRK1.36951799
31KDR1.32555679
32NTRK31.24298151
33JAK21.23411623
34MAP3K71.20549282
35EIF2AK11.19297156
36PRKAA21.12487346
37PINK11.12382934
38MAP2K31.08109844
39GRK61.08093384
40TBK11.05221406
41ERBB21.02827971
42MAP3K101.02238164
43JAK11.02023263
44MAPK41.00141675
45WNK10.97402291
46MAP3K140.97155654
47EPHA20.94490582
48EEF2K0.92823621
49PRKCZ0.92556177
50KSR20.88475046
51MET0.87163792
52MAP3K30.87152633
53STK38L0.84889623
54EPHB10.83154623
55CDK60.82459320
56MAPK150.82309079
57MAPK120.81048801
58CSNK1E0.79711245
59MAP3K110.79640902
60MAPKAPK30.77312862
61PRKACG0.77142661
62TIE10.76161601
63EPHA30.75498435
64SIK20.74766998
65CAMK2G0.71216137
66CAMK1D0.70794141
67BCR0.70679322
68CSK0.70258305
69DYRK1B0.69598886
70SGK10.68799204
71GSK3A0.67381284
72MAP2K60.66713880
73RPS6KB10.66493049
74DDR20.66160907
75PRKAA10.65292614
76NLK0.65156364
77SGK30.62164573
78RIPK10.61112142
79TGFBR20.59054932
80MAPK70.58408900
81FGFR30.58094319
82IRAK30.57905439
83BRSK20.57711551
84CSF1R0.57218689
85SCYL20.57111721
86CDK70.56736959
87PTK20.55394311
88IKBKE0.53922345
89CSNK1D0.53878466
90PRPF4B0.51916073
91PRKG10.51685453
92PRKCQ0.51683873
93SMG10.51259266
94PDPK10.51134269
95EPHA40.48734017
96CSNK1G10.48684548
97SRC0.48256448
98TAOK20.47665749
99MAP3K50.46257578
100FER0.45942459
101NEK10.45352533
102IGF1R0.44357924
103SGK20.44181558
104RET0.43762560
105MAP2K10.43758836
106GRK10.43392172
107RPS6KA30.43387606
108CDK40.42122019
109MAP3K120.41626962
110MAP3K130.41118863
111PRKCG0.40648767
112MAP3K60.40062917
113PKN10.39068960
114ICK0.38621513
115CAMKK20.38122911
116CDC42BPA0.37408805
117PRKACA0.36767519
118MTOR0.35507296
119CSNK2A10.35287445
120PBK0.35171810
121EGFR0.34742887
122CSNK2A20.34706998
123ZAP700.34075977
124PRKCB0.34032232
125FGR0.33408675
126PDK10.32368623
127CAMK40.32117789
128SGK4940.31168400
129SGK2230.31168400
130PRKACB0.29725499
131CSNK1G20.29153650
132LATS20.27310151
133CSNK1G30.25805666
134PRKCA0.25646332
135IRAK20.25105211
136IRAK10.24281125
137CAMK1G0.23549603
138MAP3K10.23023718
139PAK30.21990725
140ABL10.21703999
141MAP2K20.21331865
142BMX0.20996969
143PDK30.20397915

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53339013
2Nitrogen metabolism_Homo sapiens_hsa009103.64870495
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41525379
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36334664
5Arginine biosynthesis_Homo sapiens_hsa002203.09218326
6Complement and coagulation cascades_Homo sapiens_hsa046102.78371765
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70684564
8Tryptophan metabolism_Homo sapiens_hsa003802.68817883
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62057911
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54064117
11Fatty acid degradation_Homo sapiens_hsa000712.48842319
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37411190
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24982788
14Butanoate metabolism_Homo sapiens_hsa006502.14522812
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13314609
16Peroxisome_Homo sapiens_hsa041462.06759920
17Chemical carcinogenesis_Homo sapiens_hsa052041.94873535
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.93114409
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92662379
20Propanoate metabolism_Homo sapiens_hsa006401.92078610
21Histidine metabolism_Homo sapiens_hsa003401.89409018
22PPAR signaling pathway_Homo sapiens_hsa033201.86730278
23Fatty acid metabolism_Homo sapiens_hsa012121.81067009
24Staphylococcus aureus infection_Homo sapiens_hsa051501.76653225
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76516749
26Caffeine metabolism_Homo sapiens_hsa002321.76239409
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75096310
28Retinol metabolism_Homo sapiens_hsa008301.71044003
29beta-Alanine metabolism_Homo sapiens_hsa004101.70763477
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64839450
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60325588
32Selenocompound metabolism_Homo sapiens_hsa004501.57357797
33Phenylalanine metabolism_Homo sapiens_hsa003601.56192450
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51208927
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49720491
36Bile secretion_Homo sapiens_hsa049761.48506334
37Tyrosine metabolism_Homo sapiens_hsa003501.43879961
38Pyruvate metabolism_Homo sapiens_hsa006201.36114877
39Fatty acid elongation_Homo sapiens_hsa000621.34270725
40Sulfur metabolism_Homo sapiens_hsa009201.33825673
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32662357
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28247527
43Steroid biosynthesis_Homo sapiens_hsa001001.21188619
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21156628
45ABC transporters_Homo sapiens_hsa020101.19591234
46Folate biosynthesis_Homo sapiens_hsa007901.19162261
47Fat digestion and absorption_Homo sapiens_hsa049751.16612752
48Carbon metabolism_Homo sapiens_hsa012001.12909105
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03166684
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.99596814
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99222529
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.96987659
53Vitamin B6 metabolism_Homo sapiens_hsa007500.96590663
54Arginine and proline metabolism_Homo sapiens_hsa003300.95626239
55Sulfur relay system_Homo sapiens_hsa041220.93392851
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86379987
57Vitamin digestion and absorption_Homo sapiens_hsa049770.84871274
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82598980
59Lysine degradation_Homo sapiens_hsa003100.80803203
60One carbon pool by folate_Homo sapiens_hsa006700.75859097
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70302417
62Glycerolipid metabolism_Homo sapiens_hsa005610.66862862
63Glutathione metabolism_Homo sapiens_hsa004800.64475481
64Pentose phosphate pathway_Homo sapiens_hsa000300.58063343
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54517855
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47006639
67Metabolic pathways_Homo sapiens_hsa011000.45557895
68Pertussis_Homo sapiens_hsa051330.40521184
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39878466
70Other glycan degradation_Homo sapiens_hsa005110.38797371
71Prion diseases_Homo sapiens_hsa050200.36699028
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25096444
73Galactose metabolism_Homo sapiens_hsa000520.25008080
74Fructose and mannose metabolism_Homo sapiens_hsa000510.23705151
75Insulin resistance_Homo sapiens_hsa049310.22715398
76Linoleic acid metabolism_Homo sapiens_hsa005910.22003677
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21853501
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20383084
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.15463285
80Glucagon signaling pathway_Homo sapiens_hsa049220.09303575
81Mineral absorption_Homo sapiens_hsa049780.04903345
82N-Glycan biosynthesis_Homo sapiens_hsa005100.02218837
83AMPK signaling pathway_Homo sapiens_hsa041520.01868521
84Ether lipid metabolism_Homo sapiens_hsa00565-0.2508297
85Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2415205
86Amoebiasis_Homo sapiens_hsa05146-0.2384257
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2343951
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2288005
89Serotonergic synapse_Homo sapiens_hsa04726-0.2049501
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1980685
91Renin-angiotensin system_Homo sapiens_hsa04614-0.1937354
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1912538
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1851324
94Hepatitis C_Homo sapiens_hsa05160-0.1807269
95Circadian rhythm_Homo sapiens_hsa04710-0.1772482
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1717520
97ECM-receptor interaction_Homo sapiens_hsa04512-0.1659156
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1652087
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1555313
100Regulation of autophagy_Homo sapiens_hsa04140-0.1416449
101African trypanosomiasis_Homo sapiens_hsa05143-0.1389443
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1287103
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1031773
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0883878
105Sphingolipid metabolism_Homo sapiens_hsa00600-0.0867141
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0792045
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0700317
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0458030

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