ALDH18A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.29984852
2COPI coating of Golgi vesicle (GO:0048205)5.29984852
3folic acid-containing compound biosynthetic process (GO:0009396)5.00064052
4regulation of translational fidelity (GO:0006450)4.76279117
5DNA unwinding involved in DNA replication (GO:0006268)4.57491519
6protein localization to kinetochore (GO:0034501)4.52466510
7* proline biosynthetic process (GO:0006561)4.11840128
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94487930
9ribosomal small subunit assembly (GO:0000028)3.92574737
10IMP biosynthetic process (GO:0006188)3.84288061
11formation of translation preinitiation complex (GO:0001731)3.71126722
12mitotic nuclear envelope disassembly (GO:0007077)3.66344302
13protein localization to chromosome, centromeric region (GO:0071459)3.64308418
14establishment of integrated proviral latency (GO:0075713)3.61661458
15nuclear pore organization (GO:0006999)3.59429748
16protein retention in ER lumen (GO:0006621)3.54546276
17DNA strand elongation involved in DNA replication (GO:0006271)3.50665563
18nuclear pore complex assembly (GO:0051292)3.49938625
19nuclear envelope disassembly (GO:0051081)3.45632759
20membrane disassembly (GO:0030397)3.45632759
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42129101
22viral transcription (GO:0019083)3.41907966
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40976386
24translational termination (GO:0006415)3.37613551
25negative regulation of RNA splicing (GO:0033119)3.31623656
26protein targeting to ER (GO:0045047)3.31560733
27DNA strand elongation (GO:0022616)3.30330810
28ribosome assembly (GO:0042255)3.28405834
29cotranslational protein targeting to membrane (GO:0006613)3.28023829
30dosage compensation (GO:0007549)3.25559726
31maturation of SSU-rRNA (GO:0030490)3.24779021
32positive regulation of nuclease activity (GO:0032075)3.22068741
33DNA replication initiation (GO:0006270)3.21508205
34DNA duplex unwinding (GO:0032508)3.20039308
35translational elongation (GO:0006414)3.19686286
36tRNA aminoacylation for protein translation (GO:0006418)3.17319407
37sister chromatid segregation (GO:0000819)3.17161090
38telomere maintenance via semi-conservative replication (GO:0032201)3.16872695
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16824325
40activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.16533876
41DNA geometric change (GO:0032392)3.16159992
42mitotic chromosome condensation (GO:0007076)3.16125873
43IMP metabolic process (GO:0046040)3.12861961
44nucleobase biosynthetic process (GO:0046112)3.10368943
45translational initiation (GO:0006413)3.09407109
46tRNA aminoacylation (GO:0043039)3.07554453
47amino acid activation (GO:0043038)3.07554453
48protein complex localization (GO:0031503)3.06049079
49protein maturation by protein folding (GO:0022417)3.06032463
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.05801675
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05592642
52regulation of nuclease activity (GO:0032069)3.03596062
53protein localization to endoplasmic reticulum (GO:0070972)3.02162967
54translesion synthesis (GO:0019985)2.99459364
55mitotic sister chromatid segregation (GO:0000070)2.99206911
56nucleotide-sugar biosynthetic process (GO:0009226)2.99181161
57histone arginine methylation (GO:0034969)2.99107145
58heterochromatin organization (GO:0070828)2.98868939
59peptidyl-arginine methylation (GO:0018216)2.97978674
60peptidyl-arginine N-methylation (GO:0035246)2.97978674
61DNA replication-dependent nucleosome organization (GO:0034723)2.92383106
62DNA replication-dependent nucleosome assembly (GO:0006335)2.92383106
63negative regulation of mRNA metabolic process (GO:1903312)2.87752261
64* proline metabolic process (GO:0006560)2.87742214
65tetrahydrofolate metabolic process (GO:0046653)2.87255843
66mitotic metaphase plate congression (GO:0007080)2.86949640
67cellular protein complex localization (GO:0034629)2.86533748
68nucleobase-containing small molecule interconversion (GO:0015949)2.85985571
69negative regulation of mRNA processing (GO:0050686)2.84598176
70regulation of sister chromatid cohesion (GO:0007063)2.83913837
71mitotic sister chromatid cohesion (GO:0007064)2.81897575
72endoplasmic reticulum unfolded protein response (GO:0030968)2.80876331
73mitotic recombination (GO:0006312)2.80869460
74L-serine metabolic process (GO:0006563)2.79103544
75glucocorticoid receptor signaling pathway (GO:0042921)2.77111163
76very-low-density lipoprotein particle assembly (GO:0034379)2.76818784
77telomere maintenance via recombination (GO:0000722)2.76659776
78regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75257455
79peptidyl-arginine omega-N-methylation (GO:0035247)2.72508087
80vesicle coating (GO:0006901)2.71389966
81regulation of spindle organization (GO:0090224)2.70950861
82cellular response to unfolded protein (GO:0034620)2.70545495
83NADH metabolic process (GO:0006734)2.70480726
84establishment of viral latency (GO:0019043)2.70321297
85cellular protein complex disassembly (GO:0043624)2.69440788
86nuclear envelope organization (GO:0006998)2.69371600
87regulation of translational elongation (GO:0006448)2.69219657
88viral life cycle (GO:0019058)2.67093026
89DNA topological change (GO:0006265)2.66774266
90chromosome condensation (GO:0030261)2.66465747
91pore complex assembly (GO:0046931)2.63884420
92protein complex disassembly (GO:0043241)2.63039860
93protein localization to chromosome (GO:0034502)2.61323743
94regulation of RNA export from nucleus (GO:0046831)2.61033728
95alternative mRNA splicing, via spliceosome (GO:0000380)2.60193924
96pteridine-containing compound biosynthetic process (GO:0042559)2.59552986
97retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59252844
98ribosomal large subunit biogenesis (GO:0042273)2.58527661
99regulation of protein heterodimerization activity (GO:0043497)2.58407506
100exocrine pancreas development (GO:0031017)2.57219346
101chromatin assembly (GO:0031497)2.56125181
102desmosome organization (GO:0002934)2.55602325
103postreplication repair (GO:0006301)2.55425163
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55378047
105cellular response to topologically incorrect protein (GO:0035967)2.55234298
106urea cycle (GO:0000050)2.55140932
1074-hydroxyproline metabolic process (GO:0019471)2.54554608
108NADPH regeneration (GO:0006740)2.54463213
109* glutamine family amino acid biosynthetic process (GO:0009084)2.53599451
110nuclear-transcribed mRNA catabolic process (GO:0000956)2.53219704
111ER-nucleus signaling pathway (GO:0006984)2.53146655
112intestinal absorption (GO:0050892)2.52673109
113telomere maintenance via telomere lengthening (GO:0010833)2.52238698
114metaphase plate congression (GO:0051310)2.52151405
115spliceosomal tri-snRNP complex assembly (GO:0000244)2.51676268
116regulation of translational termination (GO:0006449)2.51531239
117DNA conformation change (GO:0071103)2.50670551
118pentose-phosphate shunt (GO:0006098)2.50436402
119histone-serine phosphorylation (GO:0035404)2.50272708
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.49995040
121nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.49145102
122COPII vesicle coating (GO:0048208)2.48948052
123regulation of mitotic spindle organization (GO:0060236)2.48524904
1243-UTR-mediated mRNA stabilization (GO:0070935)2.48292657
125DNA ligation (GO:0006266)2.48215802
126non-recombinational repair (GO:0000726)2.47576738
127double-strand break repair via nonhomologous end joining (GO:0006303)2.47576738
128plasma lipoprotein particle assembly (GO:0034377)2.46889506
129T cell apoptotic process (GO:0070231)2.46530131
130chromatin assembly or disassembly (GO:0006333)2.46512921
131serine family amino acid biosynthetic process (GO:0009070)2.45895561
132protein N-linked glycosylation via asparagine (GO:0018279)2.45787334
133rRNA transcription (GO:0009303)2.45226503
134mRNA catabolic process (GO:0006402)2.45049548
135peptidyl-asparagine modification (GO:0018196)2.44909104
136macromolecular complex disassembly (GO:0032984)2.44504531
137paraxial mesoderm development (GO:0048339)2.44311797
138mRNA stabilization (GO:0048255)2.43608413
139RNA stabilization (GO:0043489)2.43608413
140homocysteine metabolic process (GO:0050667)2.42339439
141protein export from nucleus (GO:0006611)2.41239085
142cellular response to epidermal growth factor stimulus (GO:0071364)2.34611372
143protein-DNA complex disassembly (GO:0032986)2.34492697
144nucleosome disassembly (GO:0006337)2.34492697
145regulation of cholesterol homeostasis (GO:2000188)2.32802343
146peptidyl-proline hydroxylation (GO:0019511)2.32004545
147GDP-mannose metabolic process (GO:0019673)2.31896604
148protein N-linked glycosylation (GO:0006487)2.31303027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.40005945
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04162819
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.95722849
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77996332
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.41337668
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06902301
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90921187
8MYC_22102868_ChIP-Seq_BL_Human2.86306450
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83773378
10ZNF263_19887448_ChIP-Seq_K562_Human2.48543048
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42950178
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20962214
13XRN2_22483619_ChIP-Seq_HELA_Human2.20036414
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13772718
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.07944164
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05267395
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98829651
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.98472220
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95774919
20CIITA_25753668_ChIP-Seq_RAJI_Human1.93472901
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92605557
22AR_21909140_ChIP-Seq_LNCAP_Human1.92472598
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.92077150
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87970962
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84714949
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79819989
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77082005
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75022510
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.73825587
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73330617
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72557894
32DCP1A_22483619_ChIP-Seq_HELA_Human1.72261284
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71794489
34TTF2_22483619_ChIP-Seq_HELA_Human1.69485020
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69066493
36VDR_23849224_ChIP-Seq_CD4+_Human1.67438077
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66138328
38VDR_21846776_ChIP-Seq_THP-1_Human1.62585802
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62121135
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61981589
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61113819
42GABP_19822575_ChIP-Seq_HepG2_Human1.58515657
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.56683622
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.56418428
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56299645
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53061507
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53057499
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52572817
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51503966
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49105397
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47115251
52KDM5A_27292631_Chip-Seq_BREAST_Human1.46250792
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.46046926
54* TFEB_21752829_ChIP-Seq_HELA_Human1.45813142
55ELK1_19687146_ChIP-ChIP_HELA_Human1.42239729
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41707920
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41130190
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40117356
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39739087
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39628894
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38060027
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37111681
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36992244
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34416381
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33540660
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28082081
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27421524
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26726573
69* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25719720
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24528772
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23264064
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22324330
73* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22227607
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21336722
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18494810
76ATF3_27146783_Chip-Seq_COLON_Human1.18034230
77RACK7_27058665_Chip-Seq_MCF-7_Human1.16282956
78* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15830680
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13930035
80* SOX17_20123909_ChIP-Seq_XEN_Mouse1.12674197
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12369875
82CHD1_26751641_Chip-Seq_LNCaP_Human1.11570078
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10943536
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09669265
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09096359
86UTX_26944678_Chip-Seq_JUKART_Human1.07650395
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07077270
88* GATA6_25053715_ChIP-Seq_YYC3_Human1.05471251
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04868982
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03319675
91TCF7_22412390_ChIP-Seq_EML_Mouse1.02886314
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.02533873
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02463740
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01771217
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01120125
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00220815
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99996406
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98023294
99TRIM28_21343339_ChIP-Seq_HEK293_Human0.97992332
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97660146
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97498223
102* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97219503
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96808200
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96513738
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94923892
106CLOCK_20551151_ChIP-Seq_293T_Human0.94876929
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94522407
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94177376
109* ELK3_25401928_ChIP-Seq_HUVEC_Human0.93809467
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93732841
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93690900
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93223107
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92742918
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92658925
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91559578
116MAF_26560356_Chip-Seq_TH1_Human0.91392104
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91281163
118* MYB_26560356_Chip-Seq_TH2_Human0.90260500
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89259412
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89058924
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.87428508
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87395592
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87270866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.26759175
2MP0010352_gastrointestinal_tract_polyps3.18272470
3MP0008438_abnormal_cutaneous_collagen3.16579605
4MP0006054_spinal_hemorrhage2.83153758
5MP0004957_abnormal_blastocyst_morpholog2.81549642
6MP0003705_abnormal_hypodermis_morpholog2.72670834
7MP0003111_abnormal_nucleus_morphology2.57590726
8MP0003077_abnormal_cell_cycle2.47721657
9MP0010094_abnormal_chromosome_stability2.44030686
10MP0003941_abnormal_skin_development2.25230165
11MP0002877_abnormal_melanocyte_morpholog2.17330707
12MP0005076_abnormal_cell_differentiation2.16776136
13MP0008007_abnormal_cellular_replicative2.13539036
14MP0005503_abnormal_tendon_morphology2.04333535
15MP0005360_urolithiasis2.04241924
16MP0003123_paternal_imprinting1.97660120
17MP0002396_abnormal_hematopoietic_system1.93276000
18MP0010030_abnormal_orbit_morphology1.92510392
19MP0000490_abnormal_crypts_of1.90847833
20MP0003300_gastrointestinal_ulcer1.88701828
21MP0000537_abnormal_urethra_morphology1.84942541
22MP0005220_abnormal_exocrine_pancreas1.82999191
23MP0000566_synostosis1.78352994
24MP0000350_abnormal_cell_proliferation1.77230649
25MP0001730_embryonic_growth_arrest1.75775126
26MP0010307_abnormal_tumor_latency1.72678810
27MP0001666_abnormal_nutrient_absorption1.65825048
28MP0003283_abnormal_digestive_organ1.64051746
29MP0004808_abnormal_hematopoietic_stem1.63607524
30MP0008057_abnormal_DNA_replication1.63266328
31MP0003315_abnormal_perineum_morphology1.61249696
32MP0005275_abnormal_skin_tensile1.52455873
33MP0003566_abnormal_cell_adhesion1.50801494
34MP0004197_abnormal_fetal_growth/weight/1.47438361
35MP0008932_abnormal_embryonic_tissue1.46809838
36MP0004264_abnormal_extraembryonic_tissu1.45157583
37MP0001697_abnormal_embryo_size1.43604393
38MP0002084_abnormal_developmental_patter1.40593229
39MP0009672_abnormal_birth_weight1.38696238
40MP0001672_abnormal_embryogenesis/_devel1.37067474
41MP0005380_embryogenesis_phenotype1.37067474
42MP0009697_abnormal_copulation1.36755806
43MP0008058_abnormal_DNA_repair1.36086986
44MP0002080_prenatal_lethality1.34231509
45MP0005501_abnormal_skin_physiology1.33907651
46MP0002085_abnormal_embryonic_tissue1.33546317
47MP0001661_extended_life_span1.32475027
48MP0003718_maternal_effect1.32348766
49MP0002089_abnormal_postnatal_growth/wei1.31333948
50MP0003984_embryonic_growth_retardation1.31175143
51MP0003121_genomic_imprinting1.30883495
52MP0002088_abnormal_embryonic_growth/wei1.29714934
53MP0002086_abnormal_extraembryonic_tissu1.26387476
54MP0010234_abnormal_vibrissa_follicle1.26134784
55MP0005023_abnormal_wound_healing1.23748312
56MP0000762_abnormal_tongue_morphology1.21807443
57MP0003937_abnormal_limbs/digits/tail_de1.17906870
58MP0000733_abnormal_muscle_development1.17626248
59MP0004782_abnormal_surfactant_physiolog1.17275199
60MP0009333_abnormal_splenocyte_physiolog1.16877403
61MP0003763_abnormal_thymus_physiology1.16665466
62MP0004858_abnormal_nervous_system1.16443197
63MP0000428_abnormal_craniofacial_morphol1.15976656
64MP0002796_impaired_skin_barrier1.15218862
65MP0003115_abnormal_respiratory_system1.12702986
66MP0003119_abnormal_digestive_system1.09957090
67MP0000858_altered_metastatic_potential1.04982194
68MP0003279_aneurysm1.04605801
69MP0002092_abnormal_eye_morphology1.04471832
70MP0003868_abnormal_feces_composition1.03665612
71MP0005508_abnormal_skeleton_morphology1.03422452
72MP0005409_darkened_coat_color1.02917099
73MP0002139_abnormal_hepatobiliary_system1.01460069
74MP0000313_abnormal_cell_death1.01383125
75MP0000703_abnormal_thymus_morphology1.00731930
76MP0005257_abnormal_intraocular_pressure1.00655257
77MP0002019_abnormal_tumor_incidence1.00473293
78MP0001849_ear_inflammation0.98357682
79MP0004233_abnormal_muscle_weight0.97726322
80MP0009053_abnormal_anal_canal0.97304918
81MP0002009_preneoplasia0.97179380
82MP0005451_abnormal_body_composition0.97129634
83MP0002896_abnormal_bone_mineralization0.94916434
84MP0002098_abnormal_vibrissa_morphology0.94878857
85MP0001346_abnormal_lacrimal_gland0.94839314
86MP0002060_abnormal_skin_morphology0.94757687
87MP0001944_abnormal_pancreas_morphology0.94418448
88MP0009278_abnormal_bone_marrow0.93993036
89MP0000467_abnormal_esophagus_morphology0.93643564
90MP0000477_abnormal_intestine_morphology0.92881083
91MP0003942_abnormal_urinary_system0.90477632
92MP0000678_abnormal_parathyroid_gland0.89879151
93MP0003567_abnormal_fetal_cardiomyocyte0.89747180
94MP0001348_abnormal_lacrimal_gland0.88965491
95MP0001958_emphysema0.88320675
96MP0001293_anophthalmia0.88029693
97MP0009780_abnormal_chondrocyte_physiolo0.87910575
98MP0002111_abnormal_tail_morphology0.87629356
99MP0000462_abnormal_digestive_system0.87529521
100MP0002233_abnormal_nose_morphology0.87163771
101MP0003935_abnormal_craniofacial_develop0.86534797
102MP0002932_abnormal_joint_morphology0.85953215
103MP0004134_abnormal_chest_morphology0.85654289
104MP0004272_abnormal_basement_membrane0.83756502
105MP0001881_abnormal_mammary_gland0.81748925
106MP0005621_abnormal_cell_physiology0.80924489
107MP0001915_intracranial_hemorrhage0.80891550
108MP0003890_abnormal_embryonic-extraembry0.80593863
109MP0001873_stomach_inflammation0.80493843
110MP0000627_abnormal_mammary_gland0.80231500
111MP0004185_abnormal_adipocyte_glucose0.80063032
112MP0001216_abnormal_epidermal_layer0.79471895
113MP0009384_cardiac_valve_regurgitation0.79266749
114MP0005408_hypopigmentation0.78902020
115MP0003122_maternal_imprinting0.78896498
116MP0002113_abnormal_skeleton_development0.78751611
117MP0001243_abnormal_dermal_layer0.77887428
118MP0001286_abnormal_eye_development0.77498498
119MP0000534_abnormal_ureter_morphology0.77442060
120MP0002398_abnormal_bone_marrow0.77071414
121MP0003385_abnormal_body_wall0.76777518
122MP0002697_abnormal_eye_size0.75978638
123MP0000003_abnormal_adipose_tissue0.75959933
124MP0002925_abnormal_cardiovascular_devel0.75211218
125MP0005384_cellular_phenotype0.74755813
126MP0000358_abnormal_cell_content/0.74549916
127MP0000432_abnormal_head_morphology0.73886532
128MP0002938_white_spotting0.73154844
129MP0005365_abnormal_bile_salt0.73027104
130MP0000049_abnormal_middle_ear0.72871316
131MP0000613_abnormal_salivary_gland0.72734310
132MP0009840_abnormal_foam_cell0.72135220
133MP0001299_abnormal_eye_distance/0.71680961
134MP0001545_abnormal_hematopoietic_system0.71521072
135MP0005397_hematopoietic_system_phenotyp0.71521072
136MP0002116_abnormal_craniofacial_bone0.70478276
137MP0005623_abnormal_meninges_morphology0.69578521

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.16071715
2Premature rupture of membranes (HP:0001788)3.26673881
3Ankle contracture (HP:0006466)3.00903763
4Cervical subluxation (HP:0003308)2.95097725
5Abnormality of carpal bone ossification (HP:0006257)2.76524761
6Colon cancer (HP:0003003)2.69160417
7Flat acetabular roof (HP:0003180)2.66589733
8Abnormality of glycolysis (HP:0004366)2.65415580
9Short 4th metacarpal (HP:0010044)2.63879784
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63879784
11Selective tooth agenesis (HP:0001592)2.62755107
12Small epiphyses (HP:0010585)2.58338674
13Abnormality of the calcaneus (HP:0008364)2.55733461
14Ependymoma (HP:0002888)2.55231271
15Microvesicular hepatic steatosis (HP:0001414)2.48362789
16Deviation of the thumb (HP:0009603)2.47956676
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47748732
18Bowel diverticulosis (HP:0005222)2.45252817
19Abnormal tarsal ossification (HP:0008369)2.41645077
20Rectal prolapse (HP:0002035)2.41225102
21Shallow orbits (HP:0000586)2.41105297
22Abnormal foot bone ossification (HP:0010675)2.40878285
23Abnormal ossification of hand bones (HP:0005921)2.40153829
24Genu recurvatum (HP:0002816)2.39728591
25Hypoplasia of the pons (HP:0012110)2.39401710
26Increased density of long bones (HP:0006392)2.39127345
27Aortic aneurysm (HP:0004942)2.37612048
28Thrombocytosis (HP:0001894)2.34844899
29Degeneration of anterior horn cells (HP:0002398)2.33920916
30Abnormality of the anterior horn cell (HP:0006802)2.33920916
31Reticulocytopenia (HP:0001896)2.32466047
32Proximal placement of thumb (HP:0009623)2.32244051
33Bladder diverticulum (HP:0000015)2.32230917
34Increased serum pyruvate (HP:0003542)2.30731437
35Aortic dissection (HP:0002647)2.30186358
36Dilatation of the ascending aorta (HP:0005111)2.29119927
37Chromsome breakage (HP:0040012)2.29018525
38Deep venous thrombosis (HP:0002625)2.28933793
39Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28411704
40Cerebral aneurysm (HP:0004944)2.28162582
41Hypobetalipoproteinemia (HP:0003563)2.27110708
42Renal duplication (HP:0000075)2.25056193
43Soft skin (HP:0000977)2.22702916
44Missing ribs (HP:0000921)2.22076383
45Abnormality of cells of the erythroid lineage (HP:0012130)2.19833587
46Broad palm (HP:0001169)2.19114315
47Thin bony cortex (HP:0002753)2.19112932
48Breech presentation (HP:0001623)2.17258016
49Trismus (HP:0000211)2.16910679
50Hyperacusis (HP:0010780)2.15691767
51Abnormal delivery (HP:0001787)2.12487446
52Abnormal hand bone ossification (HP:0010660)2.09452568
53Increased nuchal translucency (HP:0010880)2.09424754
5411 pairs of ribs (HP:0000878)2.08946540
55Microglossia (HP:0000171)2.07875888
56Back pain (HP:0003418)2.05856079
57Abnormal number of erythroid precursors (HP:0012131)2.04240003
58Astrocytoma (HP:0009592)2.02389101
59Abnormality of the astrocytes (HP:0100707)2.02389101
60Premature skin wrinkling (HP:0100678)2.02356570
61Abnormality of dentin (HP:0010299)1.99416838
62Insomnia (HP:0100785)1.98271013
63Overlapping toe (HP:0001845)1.98264880
64Abnormality of the distal phalanx of the thumb (HP:0009617)1.96407802
65Volvulus (HP:0002580)1.96031229
66Atrophic scars (HP:0001075)1.94203737
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92602152
68Absent epiphyses (HP:0010577)1.92602152
69Aplastic anemia (HP:0001915)1.92316421
70Abnormality of the pons (HP:0007361)1.91882669
71Overriding aorta (HP:0002623)1.91641987
72Medulloblastoma (HP:0002885)1.91211353
73Slender long bone (HP:0003100)1.90502133
74Cutaneous melanoma (HP:0012056)1.89367973
75Mesomelia (HP:0003027)1.89092942
76Malignant gastrointestinal tract tumors (HP:0006749)1.87780942
77Gastrointestinal carcinoma (HP:0002672)1.87780942
78Right ventricular cardiomyopathy (HP:0011663)1.86411753
79Natal tooth (HP:0000695)1.86197102
80Hand muscle atrophy (HP:0009130)1.86096388
81Wrist flexion contracture (HP:0001239)1.85796750
82Basal cell carcinoma (HP:0002671)1.85043175
83Spastic diplegia (HP:0001264)1.84375504
84Fragile skin (HP:0001030)1.84066767
85Pterygium (HP:0001059)1.84052268
86Advanced eruption of teeth (HP:0006288)1.83936936
87Neoplasm of the pancreas (HP:0002894)1.82084460
88Abnormal gallbladder physiology (HP:0012438)1.81701225
89Cholecystitis (HP:0001082)1.81701225
90Short nail (HP:0001799)1.81541289
91Multiple enchondromatosis (HP:0005701)1.81403765
92Abnormality of the acetabulum (HP:0003170)1.81363103
93Biconcave vertebral bodies (HP:0004586)1.80484495
94Subacute progressive viral hepatitis (HP:0006572)1.79867168
95Gout (HP:0001997)1.77876888
96Abnormality of oral frenula (HP:0000190)1.77563238
97Renovascular hypertension (HP:0100817)1.74917440
98Radial bowing (HP:0002986)1.74659741
99Abnormality of the 4th metacarpal (HP:0010012)1.74566968
100Glossoptosis (HP:0000162)1.73307825
101Patellar aplasia (HP:0006443)1.71953962
102Mitral valve prolapse (HP:0001634)1.71600363
103Disproportionate tall stature (HP:0001519)1.71257064
104Asymmetry of the thorax (HP:0001555)1.71041338
105Spinal cord compression (HP:0002176)1.70843493
106Abnormality of the distal phalanges of the toes (HP:0010182)1.70656369
107Calcaneovalgus deformity (HP:0001848)1.70632277
108Cortical dysplasia (HP:0002539)1.70318866
109Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68911096
110Pili torti (HP:0003777)1.68840411
111Abnormality of the umbilical cord (HP:0010881)1.68822683
112High pitched voice (HP:0001620)1.68439623
113Thoracolumbar scoliosis (HP:0002944)1.68176390
114Hyperammonemia (HP:0001987)1.67640186
115Deep philtrum (HP:0002002)1.66683015
116Biliary tract neoplasm (HP:0100574)1.66655699
117Vertebral arch anomaly (HP:0008438)1.66354306
118High anterior hairline (HP:0009890)1.64768808
119Blue sclerae (HP:0000592)1.64739339
120Nonimmune hydrops fetalis (HP:0001790)1.64564167
121Aplasia/Hypoplasia of the patella (HP:0006498)1.64499143
122Ankyloglossia (HP:0010296)1.63562784
123Amaurosis fugax (HP:0100576)1.63431918
124Premature ovarian failure (HP:0008209)1.63430214
125Broad thumb (HP:0011304)1.62826456
126Neonatal short-limb short stature (HP:0008921)1.62530279
127Pseudobulbar signs (HP:0002200)1.62502028
128Relative macrocephaly (HP:0004482)1.62111474
129Secondary amenorrhea (HP:0000869)1.60727342
130Long eyelashes (HP:0000527)1.60308283
131Elfin facies (HP:0004428)1.59965627
132Broad long bones (HP:0005622)1.59692298
133Nephroblastoma (Wilms tumor) (HP:0002667)1.59606384
134Midface retrusion (HP:0011800)1.59103478
135Orthostatic hypotension (HP:0001278)1.58996677
136Achilles tendon contracture (HP:0001771)1.58985605
137Abnormality of the Achilles tendon (HP:0005109)1.58959458
138Deformed tarsal bones (HP:0008119)1.57682199
139Flattened epiphyses (HP:0003071)1.57511689
140Broad phalanges of the hand (HP:0009768)1.57308578
141Peritonitis (HP:0002586)1.57296996
142Broad distal phalanx of finger (HP:0009836)1.56774468
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56222907
144Atresia of the external auditory canal (HP:0000413)1.55351968
145Aneurysm (HP:0002617)1.54577740
146Elbow flexion contracture (HP:0002987)1.54422731
147Cupped ribs (HP:0000887)1.53607659
148Short humerus (HP:0005792)1.53520545
149Vertebral hypoplasia (HP:0008417)1.53152557
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.53152557
151Ulnar bowing (HP:0003031)1.52402443
152Intestinal polyp (HP:0005266)1.52240525
153Entropion (HP:0000621)1.52112793
154Short 5th finger (HP:0009237)1.52050826
155Birth length less than 3rd percentile (HP:0003561)1.51894481
156Glioma (HP:0009733)1.51818159
157Mild short stature (HP:0003502)1.51557290
158Vertebral compression fractures (HP:0002953)1.51388038
159Abnormality of subcutaneous fat tissue (HP:0001001)1.51251170
160Ovarian neoplasm (HP:0100615)1.50949265
161Limited elbow extension (HP:0001377)1.50653635
162Myelodysplasia (HP:0002863)1.50490187
163Hallux valgus (HP:0001822)1.50220327
164Irregular epiphyses (HP:0010582)1.49398572
165Abnormality of the intrinsic pathway (HP:0010989)1.47616067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.46013855
2TRIB33.45172139
3PKN23.35403228
4PASK3.20183086
5SMG13.19109532
6CDC72.93038750
7EIF2AK12.52616574
8SCYL22.47279646
9MAP3K102.29758834
10PBK2.28309090
11FGFR42.20199544
12NEK22.13850267
13MST1R2.12209730
14ERN12.07255435
15FLT32.03253742
16BUB11.92705299
17RPS6KB21.88247334
18PDGFRA1.82596840
19VRK21.70088801
20TGFBR11.67038655
21RPS6KA41.66007668
22CDK121.52211055
23LRRK21.49084173
24NME21.47965104
25WEE11.46897821
26BRSK21.42438851
27MET1.41838917
28EIF2AK31.41639133
29PTK61.41158553
30MAP3K81.39527658
31TTK1.37480916
32STK101.36852074
33TTN1.34375447
34DDR21.28073376
35JAK31.26516789
36PAK41.26276305
37ATR1.25010029
38PAK21.22494681
39TAF11.22417156
40AURKB1.20654817
41TLK11.20219326
42LMTK21.18410570
43TSSK61.17935836
44CDK71.15365361
45CDK41.13841953
46ZAK1.10117785
47TESK11.03954480
48IRAK31.03550680
49MTOR1.03453583
50TESK21.03087760
51NEK11.01904984
52ZAP701.00511833
53PLK11.00378117
54PLK40.99561376
55CHEK10.94860196
56EPHA20.92502670
57SIK10.86727073
58ALK0.86614897
59ACVR1B0.84892096
60STK30.83761112
61BRSK10.83609091
62PIM20.82747877
63SRPK10.82176219
64ILK0.80661234
65NME10.79605691
66PLK30.79232278
67LATS10.77943983
68DYRK30.77698653
69NTRK10.76842359
70MAP4K10.76720869
71NEK90.75775451
72MAPKAPK30.75477264
73MAP2K30.75240485
74CDK60.74434174
75MKNK10.72893980
76PIM10.68835348
77CHEK20.67547677
78CDK20.65639408
79CHUK0.65416777
80ATM0.65351587
81PDGFRB0.64705418
82HIPK20.64646702
83MAPKAPK50.62783290
84TAOK30.60985940
85AURKA0.60605444
86FRK0.59529133
87VRK10.59134308
88FGFR10.58809912
89CDK90.58722205
90BMX0.58575710
91PRKG20.57919556
92BRD40.57430432
93PRKD30.57228228
94MAPK110.56917917
95PTK20.56192490
96ERBB40.56132483
97PAK10.54670430
98STK40.52888540
99CLK10.52390915
100CDK80.51573219
101FGFR30.51354396
102PDK20.50644419
103MAP2K20.50439309
104PRKCI0.50322115
105BCKDK0.50310032
106AKT20.50185765
107BCR0.49646932
108PRPF4B0.49440614
109MELK0.47671224
110CSNK1E0.47066545
111RIPK10.46553023
112DAPK10.46281757
113CSNK2A20.45879608
114TAOK10.45618528
115CDK10.43831274
116CDK11A0.43802113
117BTK0.43634962
118EPHA30.43488018
119CDK150.42783188
120CCNB10.42383374
121ICK0.41517892
122RPS6KA20.41334405
123RPS6KB10.41192630
124MAP3K30.40648361
125CDK180.40085601
126LATS20.39802572
127BRAF0.39153659
128MAPKAPK20.37856176
129KSR20.37762276
130PRKDC0.37034411
131RPS6KC10.37005964
132EIF2AK20.36208415

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.48262033
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.36469224
3One carbon pool by folate_Homo sapiens_hsa006702.98624870
4Mismatch repair_Homo sapiens_hsa034302.83266634
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55786653
6* Biosynthesis of amino acids_Homo sapiens_hsa012302.42621707
7Spliceosome_Homo sapiens_hsa030402.40698464
8Cell cycle_Homo sapiens_hsa041102.36283217
9Base excision repair_Homo sapiens_hsa034102.34257192
10RNA transport_Homo sapiens_hsa030132.34135047
11Ribosome_Homo sapiens_hsa030102.21345892
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19092123
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11531350
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04380937
15Pentose phosphate pathway_Homo sapiens_hsa000301.94526470
16Carbon metabolism_Homo sapiens_hsa012001.88271011
17Nucleotide excision repair_Homo sapiens_hsa034201.86552483
18Protein export_Homo sapiens_hsa030601.82774716
19Vitamin digestion and absorption_Homo sapiens_hsa049771.77012039
20Fructose and mannose metabolism_Homo sapiens_hsa000511.76083527
21Arginine biosynthesis_Homo sapiens_hsa002201.69248241
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63387098
23N-Glycan biosynthesis_Homo sapiens_hsa005101.62620892
24p53 signaling pathway_Homo sapiens_hsa041151.58957908
25mRNA surveillance pathway_Homo sapiens_hsa030151.53407737
26Homologous recombination_Homo sapiens_hsa034401.50607931
27Chronic myeloid leukemia_Homo sapiens_hsa052201.42739719
28RNA degradation_Homo sapiens_hsa030181.37959564
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.36219642
30Viral carcinogenesis_Homo sapiens_hsa052031.35895801
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34086310
32Non-homologous end-joining_Homo sapiens_hsa034501.32435941
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29754097
34Sulfur relay system_Homo sapiens_hsa041221.29109337
35Pyruvate metabolism_Homo sapiens_hsa006201.28612306
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.25271614
37Vitamin B6 metabolism_Homo sapiens_hsa007501.24197671
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23826903
39Bladder cancer_Homo sapiens_hsa052191.23447019
40Steroid biosynthesis_Homo sapiens_hsa001001.22806493
41Small cell lung cancer_Homo sapiens_hsa052221.22728113
42MicroRNAs in cancer_Homo sapiens_hsa052061.22409017
43Pyrimidine metabolism_Homo sapiens_hsa002401.22046327
44Protein digestion and absorption_Homo sapiens_hsa049741.19570076
45HTLV-I infection_Homo sapiens_hsa051661.18014985
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17906954
47Fatty acid elongation_Homo sapiens_hsa000621.16926631
48Antigen processing and presentation_Homo sapiens_hsa046121.15818185
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14010049
50Colorectal cancer_Homo sapiens_hsa052101.12716554
51RNA polymerase_Homo sapiens_hsa030201.12604626
52Thyroid cancer_Homo sapiens_hsa052161.06559678
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05947800
54Fanconi anemia pathway_Homo sapiens_hsa034601.04414403
55Fatty acid metabolism_Homo sapiens_hsa012121.01857059
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01163892
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99954695
58Epstein-Barr virus infection_Homo sapiens_hsa051690.97791946
59Lysine degradation_Homo sapiens_hsa003100.96658368
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95999794
61* Arginine and proline metabolism_Homo sapiens_hsa003300.94820846
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94073904
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.91754824
64Endometrial cancer_Homo sapiens_hsa052130.89583337
65Hepatitis B_Homo sapiens_hsa051610.89496631
66Systemic lupus erythematosus_Homo sapiens_hsa053220.89441837
67Adherens junction_Homo sapiens_hsa045200.89437238
68Proteasome_Homo sapiens_hsa030500.89176029
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88408625
70Legionellosis_Homo sapiens_hsa051340.87941059
71Pancreatic cancer_Homo sapiens_hsa052120.87741690
72Selenocompound metabolism_Homo sapiens_hsa004500.87711483
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87424463
74Herpes simplex infection_Homo sapiens_hsa051680.87051988
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86394909
76Apoptosis_Homo sapiens_hsa042100.86233992
77ECM-receptor interaction_Homo sapiens_hsa045120.85128904
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.84728873
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84654401
80Focal adhesion_Homo sapiens_hsa045100.84304706
81Glutathione metabolism_Homo sapiens_hsa004800.83873069
82Phenylalanine metabolism_Homo sapiens_hsa003600.83401268
83Sulfur metabolism_Homo sapiens_hsa009200.82825759
84Other glycan degradation_Homo sapiens_hsa005110.82467362
85Prostate cancer_Homo sapiens_hsa052150.82188951
86Non-small cell lung cancer_Homo sapiens_hsa052230.82023396
87Acute myeloid leukemia_Homo sapiens_hsa052210.81728434
88Notch signaling pathway_Homo sapiens_hsa043300.81719704
89mTOR signaling pathway_Homo sapiens_hsa041500.80279859
90Proteoglycans in cancer_Homo sapiens_hsa052050.79611876
91Viral myocarditis_Homo sapiens_hsa054160.79177467
92Hippo signaling pathway_Homo sapiens_hsa043900.78188348
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75819749
94Starch and sucrose metabolism_Homo sapiens_hsa005000.74879004
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73342076
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72887916
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72357997
98Shigellosis_Homo sapiens_hsa051310.71646822
99Propanoate metabolism_Homo sapiens_hsa006400.70396555
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.67802413
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67517939
102Folate biosynthesis_Homo sapiens_hsa007900.65749007
103Prolactin signaling pathway_Homo sapiens_hsa049170.65632676
104Measles_Homo sapiens_hsa051620.65378773
105TGF-beta signaling pathway_Homo sapiens_hsa043500.65223595
106Galactose metabolism_Homo sapiens_hsa000520.62449156
107Toxoplasmosis_Homo sapiens_hsa051450.62211816
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61850284
109Basal cell carcinoma_Homo sapiens_hsa052170.60415084
110Alcoholism_Homo sapiens_hsa050340.60374512
111Basal transcription factors_Homo sapiens_hsa030220.60302894
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59221164
113HIF-1 signaling pathway_Homo sapiens_hsa040660.58820074
114Renin-angiotensin system_Homo sapiens_hsa046140.58627330
115Influenza A_Homo sapiens_hsa051640.58491450
116Pathways in cancer_Homo sapiens_hsa052000.57866880
117Oocyte meiosis_Homo sapiens_hsa041140.53224943
118Fatty acid degradation_Homo sapiens_hsa000710.52708171
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.52152509
120Melanoma_Homo sapiens_hsa052180.52091351
121Thyroid hormone synthesis_Homo sapiens_hsa049180.51774009
122Pancreatic secretion_Homo sapiens_hsa049720.51702828
123Purine metabolism_Homo sapiens_hsa002300.51200586
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51013403
125Fat digestion and absorption_Homo sapiens_hsa049750.48911651
126Primary immunodeficiency_Homo sapiens_hsa053400.48793081
127TNF signaling pathway_Homo sapiens_hsa046680.47689342
128Glioma_Homo sapiens_hsa052140.46894335
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45878023
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.45656131
131Tight junction_Homo sapiens_hsa045300.45533263
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.44309180
133T cell receptor signaling pathway_Homo sapiens_hsa046600.43515083
134FoxO signaling pathway_Homo sapiens_hsa040680.43421398
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42274219
136Fatty acid biosynthesis_Homo sapiens_hsa000610.41919422
137Sphingolipid metabolism_Homo sapiens_hsa006000.41460989
138VEGF signaling pathway_Homo sapiens_hsa043700.41281202
139Leishmaniasis_Homo sapiens_hsa051400.40014135
140Tyrosine metabolism_Homo sapiens_hsa003500.39099331
141* Metabolic pathways_Homo sapiens_hsa011000.38821340
142Vibrio cholerae infection_Homo sapiens_hsa051100.38604265
143Platelet activation_Homo sapiens_hsa046110.38134076
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37574020
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37052413
146AMPK signaling pathway_Homo sapiens_hsa041520.32840099

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »