ALDH1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.67737975
2primary alcohol catabolic process (GO:0034310)7.63913644
3L-phenylalanine catabolic process (GO:0006559)6.81626501
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.81626501
5L-phenylalanine metabolic process (GO:0006558)6.51735198
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51735198
7aromatic amino acid family catabolic process (GO:0009074)6.05512256
8alkaloid metabolic process (GO:0009820)5.88908132
9glycoside metabolic process (GO:0016137)5.88780229
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67903651
11alpha-linolenic acid metabolic process (GO:0036109)5.58431001
12bile acid biosynthetic process (GO:0006699)5.48579463
13kynurenine metabolic process (GO:0070189)5.42422037
14tryptophan catabolic process (GO:0006569)5.41325184
15indole-containing compound catabolic process (GO:0042436)5.41325184
16indolalkylamine catabolic process (GO:0046218)5.41325184
17glyoxylate metabolic process (GO:0046487)5.15645424
18cysteine metabolic process (GO:0006534)5.12518901
19negative regulation of fibrinolysis (GO:0051918)5.11578871
20complement activation, alternative pathway (GO:0006957)5.10640268
21sulfur amino acid catabolic process (GO:0000098)5.10080619
22tyrosine metabolic process (GO:0006570)5.09422941
23tryptophan metabolic process (GO:0006568)5.08244621
24urea cycle (GO:0000050)5.08058103
25urea metabolic process (GO:0019627)5.08058103
26regulation of protein activation cascade (GO:2000257)5.04018634
27high-density lipoprotein particle remodeling (GO:0034375)5.01628862
28protein carboxylation (GO:0018214)4.83863468
29peptidyl-glutamic acid carboxylation (GO:0017187)4.83863468
30regulation of fibrinolysis (GO:0051917)4.79860799
31regulation of complement activation (GO:0030449)4.77590650
32bile acid metabolic process (GO:0008206)4.70930464
33nitrogen cycle metabolic process (GO:0071941)4.68830975
34aromatic amino acid family metabolic process (GO:0009072)4.63722337
35bile acid and bile salt transport (GO:0015721)4.61707772
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.60733762
37* ethanol oxidation (GO:0006069)4.59004877
38progesterone metabolic process (GO:0042448)4.52231281
39benzene-containing compound metabolic process (GO:0042537)4.50417743
40reverse cholesterol transport (GO:0043691)4.48359239
41homocysteine metabolic process (GO:0050667)4.47669913
42indolalkylamine metabolic process (GO:0006586)4.42137246
43serine family amino acid catabolic process (GO:0009071)4.39836342
44phenylpropanoid metabolic process (GO:0009698)4.39594248
45coenzyme catabolic process (GO:0009109)4.32208680
46amino-acid betaine metabolic process (GO:0006577)4.31730371
47regulation of triglyceride catabolic process (GO:0010896)4.31184005
48plasma lipoprotein particle remodeling (GO:0034369)4.27571529
49protein-lipid complex remodeling (GO:0034368)4.27571529
50macromolecular complex remodeling (GO:0034367)4.27571529
51regulation of cholesterol esterification (GO:0010872)4.26952210
52lysine metabolic process (GO:0006553)4.24239773
53lysine catabolic process (GO:0006554)4.24239773
54cellular ketone body metabolic process (GO:0046950)4.22457004
55dopamine transport (GO:0015872)4.16081587
56triglyceride homeostasis (GO:0070328)4.15327426
57acylglycerol homeostasis (GO:0055090)4.15327426
58alpha-amino acid catabolic process (GO:1901606)4.13712681
59negative regulation of sterol transport (GO:0032372)4.02870828
60negative regulation of cholesterol transport (GO:0032375)4.02870828
61glutamate metabolic process (GO:0006536)4.01581826
62phospholipid efflux (GO:0033700)3.99993005
63plasma lipoprotein particle clearance (GO:0034381)3.90264555
64cellular glucuronidation (GO:0052695)3.89720417
65aldehyde catabolic process (GO:0046185)3.88000393
66cellular amino acid catabolic process (GO:0009063)3.87456775
67cholesterol efflux (GO:0033344)3.87175609
68macroautophagy (GO:0016236)3.84774447
69drug catabolic process (GO:0042737)3.76190933
70dicarboxylic acid biosynthetic process (GO:0043650)3.74966808
71axonemal dynein complex assembly (GO:0070286)3.70157890
72cellular biogenic amine catabolic process (GO:0042402)3.69086485
73amine catabolic process (GO:0009310)3.69086485
74response to nitrosative stress (GO:0051409)3.67902664
75cellular modified amino acid catabolic process (GO:0042219)3.67685451
76toxin transport (GO:1901998)3.66629300
77imidazole-containing compound metabolic process (GO:0052803)3.65181601
78ketone body metabolic process (GO:1902224)3.64395011
79quinone metabolic process (GO:1901661)3.62558217
80glycine metabolic process (GO:0006544)3.61838729
81epoxygenase P450 pathway (GO:0019373)3.59354141
82flavonoid metabolic process (GO:0009812)3.58435917
83* primary alcohol metabolic process (GO:0034308)3.56385851
84C21-steroid hormone metabolic process (GO:0008207)3.56173579
85serine family amino acid metabolic process (GO:0009069)3.56154994
86phospholipid homeostasis (GO:0055091)3.55798847
87complement activation, classical pathway (GO:0006958)3.55737498
88short-chain fatty acid metabolic process (GO:0046459)3.54191402
89uronic acid metabolic process (GO:0006063)3.53617819
90glucuronate metabolic process (GO:0019585)3.53617819
91arginine metabolic process (GO:0006525)3.51793661
92plasma lipoprotein particle assembly (GO:0034377)3.51441155
93fibrinolysis (GO:0042730)3.51307942
94low-density lipoprotein particle remodeling (GO:0034374)3.51239756
95cofactor catabolic process (GO:0051187)3.50160374
96negative regulation of lipase activity (GO:0060192)3.49807574
97complement activation (GO:0006956)3.49257632
98cytolysis (GO:0019835)3.47690199
99dopamine biosynthetic process (GO:0042416)3.47370225
100regulation of cholesterol homeostasis (GO:2000188)3.46759702
101positive regulation of lipid catabolic process (GO:0050996)3.46196269
102drug transmembrane transport (GO:0006855)3.46002254
103organic acid catabolic process (GO:0016054)3.45735828
104carboxylic acid catabolic process (GO:0046395)3.45735828
105retinal metabolic process (GO:0042574)3.43487170
106acetyl-CoA metabolic process (GO:0006084)3.42613627
107exogenous drug catabolic process (GO:0042738)3.42514016
108cholesterol homeostasis (GO:0042632)3.40820577
109negative regulation of protein activation cascade (GO:2000258)3.39285056
110vitamin D metabolic process (GO:0042359)3.39035938
111secondary metabolic process (GO:0019748)3.38272652
112protein activation cascade (GO:0072376)3.38265073
113opsonization (GO:0008228)3.37137008
114very-low-density lipoprotein particle assembly (GO:0034379)3.36350426
115sterol homeostasis (GO:0055092)3.36050530
116* ethanol metabolic process (GO:0006067)3.35847233
117regulation of extracellular matrix disassembly (GO:0010715)3.34197901
118regulation of type B pancreatic cell apoptotic process (GO:2000674)3.33442014
119negative regulation of hormone metabolic process (GO:0032351)3.31593396
120negative regulation of complement activation (GO:0045916)3.22518815
121negative regulation of execution phase of apoptosis (GO:1900118)3.21353376
122cellular response to vitamin D (GO:0071305)3.19731079
123cilium or flagellum-dependent cell motility (GO:0001539)3.12203905
124L-alpha-amino acid transmembrane transport (GO:1902475)3.11741567
125cilium movement (GO:0003341)3.09675050
126intestinal cholesterol absorption (GO:0030299)3.07182058
127alcohol catabolic process (GO:0046164)3.06623986
128negative regulation of humoral immune response (GO:0002921)3.06362335
129peptide hormone processing (GO:0016486)3.03876656
130retinoic acid metabolic process (GO:0042573)3.01076641
131* cellular aldehyde metabolic process (GO:0006081)2.99277602
132drug metabolic process (GO:0017144)2.97691509
133insulin secretion (GO:0030073)2.96950055
134organic cation transport (GO:0015695)2.96390172
135vitamin transmembrane transport (GO:0035461)2.95723965
136positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.90487828
137glomerular epithelial cell development (GO:0072310)2.85905272
138endocrine pancreas development (GO:0031018)2.85303789
139epithelial cilium movement (GO:0003351)2.84603666
140fat-soluble vitamin catabolic process (GO:0042363)2.80852358
141vitamin catabolic process (GO:0009111)2.80852358
142regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.80192362
143organic hydroxy compound catabolic process (GO:1901616)2.79073894
144nitric oxide biosynthetic process (GO:0006809)2.77578266
145quaternary ammonium group transport (GO:0015697)2.76836946
146drug transport (GO:0015893)2.75856240
147androgen biosynthetic process (GO:0006702)2.74364224
148COPII vesicle coating (GO:0048208)2.64098836
149axoneme assembly (GO:0035082)2.61405824
150auditory receptor cell differentiation (GO:0042491)2.61015069
151xenobiotic catabolic process (GO:0042178)2.59749277
152artery smooth muscle contraction (GO:0014824)2.58756155
153detection of calcium ion (GO:0005513)2.55830541
154epithelial cell fate commitment (GO:0072148)2.55741524
155positive regulation of macroautophagy (GO:0016239)2.55100788
156renal absorption (GO:0070293)2.52381712
157positive regulation of actin filament depolymerization (GO:0030836)2.49957199
158* retinol metabolic process (GO:0042572)2.47127638
159water-soluble vitamin biosynthetic process (GO:0042364)2.46458551
160tonic smooth muscle contraction (GO:0014820)2.46104452
161catecholamine transport (GO:0051937)2.45258698
162L-ascorbic acid metabolic process (GO:0019852)2.42345410
163* cellular hormone metabolic process (GO:0034754)2.42322440
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41513004
165nephron tubule morphogenesis (GO:0072078)2.40438768
166nephron epithelium morphogenesis (GO:0072088)2.40438768
167glycerophospholipid catabolic process (GO:0046475)2.39967776
168glomerular basement membrane development (GO:0032836)2.39290450
169daunorubicin metabolic process (GO:0044597)10.8594224
170polyketide metabolic process (GO:0030638)10.8594224
171doxorubicin metabolic process (GO:0044598)10.8594224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.37404099
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.96742280
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.19650496
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.92542062
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.77638607
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86905119
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.81101544
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.02659538
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62506215
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.09617541
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.15212134
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4939970
13GBX2_23144817_ChIP-Seq_PC3_Human1.90676936
14CLOCK_20551151_ChIP-Seq_293T_Human1.88851519
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85148887
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85143937
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83058631
18GATA1_22025678_ChIP-Seq_K562_Human1.82764347
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.66179591
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59423621
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54340231
22* CJUN_26792858_Chip-Seq_BT549_Human1.53109481
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51766403
24AHR_22903824_ChIP-Seq_MCF-7_Human1.43625874
25TAF15_26573619_Chip-Seq_HEK293_Human1.42926252
26HTT_18923047_ChIP-ChIP_STHdh_Human1.41870202
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.38102431
28SMAD4_21799915_ChIP-Seq_A2780_Human1.37485613
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35262851
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34726295
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.33600346
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32773927
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32512296
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28731619
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19990298
36* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18278078
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.17818934
38ZNF263_19887448_ChIP-Seq_K562_Human1.16596731
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15766726
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15310350
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15226843
42ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14375549
43* STAT3_23295773_ChIP-Seq_U87_Human1.14141212
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.10984571
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.10590511
46CDX2_22108803_ChIP-Seq_LS180_Human1.10397386
47BCAT_22108803_ChIP-Seq_LS180_Human1.10005530
48* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09163214
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09062729
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08833270
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.08119923
52RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07647531
53* TP63_23658742_ChIP-Seq_EP156T_Human1.05531098
54* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05237060
55SMAD3_21741376_ChIP-Seq_HESCs_Human1.05184988
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03757074
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03476055
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.02423323
59* AR_25329375_ChIP-Seq_VCAP_Human1.01176642
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99896653
61ZNF274_21170338_ChIP-Seq_K562_Hela0.99824324
62BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99518879
63PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98730428
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98418760
65STAT3_18555785_Chip-Seq_ESCs_Mouse0.98012343
66* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96648061
67* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96648061
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95592272
69NANOG_18555785_Chip-Seq_ESCs_Mouse0.95353843
70SOX2_18555785_Chip-Seq_ESCs_Mouse0.95268181
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95116111
72MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95038465
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94915948
74CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94567203
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94343496
76GATA6_25053715_ChIP-Seq_YYC3_Human0.94096914
77P53_22387025_ChIP-Seq_ESCs_Mouse0.93665015
78SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92938152
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92136589
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91158940
81CTCF_18555785_Chip-Seq_ESCs_Mouse0.90883691
82SMAD4_21741376_ChIP-Seq_HESCs_Human0.90683103
83GATA4_25053715_ChIP-Seq_YYC3_Human0.90070267
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89491472
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88969458
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88503934
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.88107979
88CBP_20019798_ChIP-Seq_JUKART_Human0.88014702
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88014702
90RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86113399
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.80919737
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73283247
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71773542
94* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71563470
95* PIAS1_25552417_ChIP-Seq_VCAP_Human0.71136554
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70306475
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70304719
98* SOX2_20726797_ChIP-Seq_SW620_Human0.70145913
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68297462
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.68015118
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66749257
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66738972
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.64424527
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.63079107
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61934014
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61472688
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.61325254
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60982367
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.59535894
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.59220388
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59214140
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58895814
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.58078141
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58005360
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.56335292
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.55673458
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.55206498
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55062665
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54921017
120* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54448387
121CBP_21632823_ChIP-Seq_H3396_Human0.54301621
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.53769932
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53124873
124CEBPB_22108803_ChIP-Seq_LS180_Human0.52815882
125MYC_19915707_ChIP-ChIP_AK7_Human0.52358353
126LXR_22292898_ChIP-Seq_THP-1_Human0.52356805
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.52301000
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50364164
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50080900
130STAT1_17558387_ChIP-Seq_HELA_Human0.49901777
131CTCF_27219007_Chip-Seq_Bcells_Human0.48374292
132TP53_16413492_ChIP-PET_HCT116_Human0.47190915
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.47088108
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.46516394
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.46455225
136GATA1_19941826_ChIP-Seq_K562_Human0.46404533
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.45951931
138MYC_27129775_Chip-Seq_CORNEA_Mouse0.45631950
139* GATA2_19941826_ChIP-Seq_K562_Human0.45475366
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.45104799
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.44940639
142EGR1_19032775_ChIP-ChIP_M12_Human0.44368364
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.44167707
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.44140839
145AR_20517297_ChIP-Seq_VCAP_Human0.43831558
146* RARB_24833708_ChIP-Seq_LIVER_Mouse0.43720183
147SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.42942833
148TAF2_19829295_ChIP-Seq_ESCs_Human0.42918229
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.42657952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002139_abnormal_hepatobiliary_system8.24774512
2MP0005360_urolithiasis6.93120872
3MP0005085_abnormal_gallbladder_physiolo6.01870587
4MP0005365_abnormal_bile_salt5.85687813
5MP0008875_abnormal_xenobiotic_pharmacok5.40168665
6MP0003806_abnormal_nucleotide_metabolis3.80441632
7MP0000013_abnormal_adipose_tissue3.74596424
8MP0003252_abnormal_bile_duct3.65844832
9MP0010329_abnormal_lipoprotein_level3.54474673
10MP0005379_endocrine/exocrine_gland_phen3.08805450
11MP0005083_abnormal_biliary_tract3.08266132
12MP0001666_abnormal_nutrient_absorption2.79165458
13MP0009840_abnormal_foam_cell2.70454172
14MP0003195_calcinosis2.65869988
15MP0005332_abnormal_amino_acid2.51885264
16MP0001944_abnormal_pancreas_morphology2.42656254
17MP0005645_abnormal_hypothalamus_physiol2.19102152
18MP0003868_abnormal_feces_composition2.16582068
19MP0003191_abnormal_cellular_cholesterol2.12675080
20MP0002118_abnormal_lipid_homeostasis2.04932061
21MP0002138_abnormal_hepatobiliary_system2.02892457
22MP0010386_abnormal_urinary_bladder1.99418253
23MP0000609_abnormal_liver_physiology1.98940645
24MP0004019_abnormal_vitamin_homeostasis1.95156295
25MP0004043_abnormal_pH_regulation1.85586543
26MP0004133_heterotaxia1.85209418
27MP0002693_abnormal_pancreas_physiology1.81838358
28MP0002822_catalepsy1.70744178
29MP0005319_abnormal_enzyme/_coenzyme1.70497074
30MP0005584_abnormal_enzyme/coenzyme_acti1.70200668
31MP0004270_analgesia1.69144486
32MP0002163_abnormal_gland_morphology1.67736382
33MP0003283_abnormal_digestive_organ1.64481152
34MP0000003_abnormal_adipose_tissue1.51579895
35MP0001765_abnormal_ion_homeostasis1.46402013
36MP0001764_abnormal_homeostasis1.38498580
37MP0010678_abnormal_skin_adnexa1.29413720
38MP0001905_abnormal_dopamine_level1.26265327
39MP0005647_abnormal_sex_gland1.25945530
40MP0010352_gastrointestinal_tract_polyps1.23747141
41MP0009697_abnormal_copulation1.21351324
42MP0009643_abnormal_urine_homeostasis1.16812926
43MP0008775_abnormal_heart_ventricle1.16423748
44MP0003186_abnormal_redox_activity1.13193596
45MP0003172_abnormal_lysosome_physiology1.12367006
46MP0002909_abnormal_adrenal_gland1.12139855
47MP0009764_decreased_sensitivity_to1.11894945
48MP0000639_abnormal_adrenal_gland1.10437737
49MP0008438_abnormal_cutaneous_collagen1.07951473
50MP0005646_abnormal_pituitary_gland1.07760181
51MP0002254_reproductive_system_inflammat1.07757996
52MP0003705_abnormal_hypodermis_morpholog1.07347705
53MP0005535_abnormal_body_temperature1.05750346
54MP0006072_abnormal_retinal_apoptosis1.05528813
55MP0005058_abnormal_lysosome_morphology1.03575786
56MP0003011_delayed_dark_adaptation1.02064452
57MP0003656_abnormal_erythrocyte_physiolo1.01884976
58MP0010368_abnormal_lymphatic_system1.00899689
59MP0000598_abnormal_liver_morphology1.00144446
60MP0000604_amyloidosis0.99270159
61MP0001984_abnormal_olfaction0.97852887
62MP0008872_abnormal_physiological_respon0.95257022
63MP0003879_abnormal_hair_cell0.94201785
64MP0004130_abnormal_muscle_cell0.93016239
65MP0009046_muscle_twitch0.92375010
66MP0005376_homeostasis/metabolism_phenot0.91385791
67MP0003880_abnormal_central_pattern0.90902643
68MP0005636_abnormal_mineral_homeostasis0.90455865
69MP0000383_abnormal_hair_follicle0.89488537
70MP0001501_abnormal_sleep_pattern0.88429461
71MP0003690_abnormal_glial_cell0.84750739
72MP0005408_hypopigmentation0.83387605
73MP0010234_abnormal_vibrissa_follicle0.81891667
74MP0006276_abnormal_autonomic_nervous0.81755375
75MP0001661_extended_life_span0.81329405
76MP0004782_abnormal_surfactant_physiolog0.79875177
77MP0000613_abnormal_salivary_gland0.79850791
78MP0009763_increased_sensitivity_to0.79760602
79MP0006036_abnormal_mitochondrial_physio0.79261149
80MP0000462_abnormal_digestive_system0.78126360
81MP0005451_abnormal_body_composition0.76759206
82MP0003329_amyloid_beta_deposits0.76668696
83MP0004147_increased_porphyrin_level0.76491864
84MP0009642_abnormal_blood_homeostasis0.76365427
85MP0003633_abnormal_nervous_system0.72630698
86MP0005266_abnormal_metabolism0.72394769
87MP0005334_abnormal_fat_pad0.71974618
88MP0002078_abnormal_glucose_homeostasis0.69902728
89MP0009765_abnormal_xenobiotic_induced0.69751888
90MP0002896_abnormal_bone_mineralization0.68914388
91MP0002277_abnormal_respiratory_mucosa0.68523803
92MP0008469_abnormal_protein_level0.68234188
93MP0005220_abnormal_exocrine_pancreas0.68137756
94MP0002090_abnormal_vision0.66056362
95MP0004085_abnormal_heartbeat0.66027583
96MP0003566_abnormal_cell_adhesion0.65669391
97MP0001756_abnormal_urination0.65209965
98MP0003122_maternal_imprinting0.62438521
99MP0008874_decreased_physiological_sensi0.62403365
100MP0004215_abnormal_myocardial_fiber0.62385778
101MP0002876_abnormal_thyroid_physiology0.62049550
102MP0005551_abnormal_eye_electrophysiolog0.62023383
103MP0002160_abnormal_reproductive_system0.61378476
104MP0002837_dystrophic_cardiac_calcinosis0.61169306
105MP0004883_abnormal_blood_vessel0.61029082
106MP0006035_abnormal_mitochondrial_morpho0.60506824
107MP0003091_abnormal_cell_migration0.60263514
108MP0005165_increased_susceptibility_to0.59730411
109MP0004272_abnormal_basement_membrane0.59524116
110MP0005167_abnormal_blood-brain_barrier0.58988414
111MP0002971_abnormal_brown_adipose0.58745039
112MP0001881_abnormal_mammary_gland0.58432428
113MP0005084_abnormal_gallbladder_morpholo0.58078309
114MP0005389_reproductive_system_phenotype0.56698981
115MP0005164_abnormal_response_to0.56569802
116MP0005670_abnormal_white_adipose0.55484191
117MP0001529_abnormal_vocalization0.53827989
118MP0009384_cardiac_valve_regurgitation0.53362789
119MP0006054_spinal_hemorrhage0.52791753
120MP0005375_adipose_tissue_phenotype0.52561062
121MP0005409_darkened_coat_color0.52312849
122MP0008873_increased_physiological_sensi0.51634967
123MP0001270_distended_abdomen0.51113476
124MP0003638_abnormal_response/metabolism_0.50862670
125MP0002168_other_aberrant_phenotype0.50228983
126MP0005448_abnormal_energy_balance0.48594450
127MP0003724_increased_susceptibility_to0.48541776
128MP0000538_abnormal_urinary_bladder0.47760331
129MP0003953_abnormal_hormone_level0.46493645
130MP0005395_other_phenotype0.45558778
131MP0000230_abnormal_systemic_arterial0.43458553
132MP0002136_abnormal_kidney_physiology0.41327370
133MP0009053_abnormal_anal_canal0.40588647
134MP0000249_abnormal_blood_vessel0.40564538
135MP0002295_abnormal_pulmonary_circulatio0.40078445
136MP0001664_abnormal_digestion0.38144827
137MP0009780_abnormal_chondrocyte_physiolo0.37678686
138MP0005166_decreased_susceptibility_to0.37430952
139MP0005464_abnormal_platelet_physiology0.37387180
140MP0002332_abnormal_exercise_endurance0.36705258
141MP0003632_abnormal_nervous_system0.36493991
142MP0005187_abnormal_penis_morphology0.35558226
143MP0002928_abnormal_bile_duct0.34673760
144MP0004924_abnormal_behavior0.32344886
145MP0005386_behavior/neurological_phenoty0.32344886
146MP0002796_impaired_skin_barrier0.31752830

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.15628890
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83427237
3Intrahepatic cholestasis (HP:0001406)6.72391920
4Hypobetalipoproteinemia (HP:0003563)6.13403562
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.09621093
6Xanthomatosis (HP:0000991)5.79700200
7Prolonged partial thromboplastin time (HP:0003645)5.70957761
8Complement deficiency (HP:0004431)5.36058719
9Hyperlipoproteinemia (HP:0010980)5.15386888
10Hypolipoproteinemia (HP:0010981)4.48054349
11Hyperammonemia (HP:0001987)4.25847030
12Joint hemorrhage (HP:0005261)4.21014076
13Epidermoid cyst (HP:0200040)4.11861549
14Abnormal respiratory epithelium morphology (HP:0012253)4.11463479
15Abnormal respiratory motile cilium morphology (HP:0005938)4.11463479
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.09917703
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07666203
18Hyperglycinemia (HP:0002154)4.05706471
19Abnormality of the common coagulation pathway (HP:0010990)3.99413178
20Fat malabsorption (HP:0002630)3.95516635
21Ketosis (HP:0001946)3.94030590
22Limb dystonia (HP:0002451)3.91577169
23Abnormal ciliary motility (HP:0012262)3.87772275
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78515932
25Hypoalphalipoproteinemia (HP:0003233)3.77867939
26Abnormality of complement system (HP:0005339)3.77812090
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.75576698
28Absent/shortened dynein arms (HP:0200106)3.75576698
29Rhinitis (HP:0012384)3.75293015
30Abnormal respiratory motile cilium physiology (HP:0012261)3.72071215
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.70524325
32Abnormal sex determination (HP:0012244)3.62912748
33Sex reversal (HP:0012245)3.62912748
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.59377519
35Abnormality of methionine metabolism (HP:0010901)3.58844379
36Abnormality of glycine metabolism (HP:0010895)3.54926558
37Abnormality of serine family amino acid metabolism (HP:0010894)3.54926558
38Hyperglycinuria (HP:0003108)3.53899364
39Abnormality of the intrinsic pathway (HP:0010989)3.44291915
40Hypoglycemic coma (HP:0001325)3.41382624
41Hypercholesterolemia (HP:0003124)3.32159104
42Conjugated hyperbilirubinemia (HP:0002908)3.31416965
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17010680
44Proximal tubulopathy (HP:0000114)3.04764443
45Abnormality of fatty-acid metabolism (HP:0004359)3.01343186
46Increased CSF protein (HP:0002922)3.01247338
47Steatorrhea (HP:0002570)2.97523118
48Hyperglycemia (HP:0003074)2.96118635
49Hyperbilirubinemia (HP:0002904)2.94194456
50Urinary glycosaminoglycan excretion (HP:0003541)2.93305260
51Mucopolysacchariduria (HP:0008155)2.93305260
52Abnormality of pyrimidine metabolism (HP:0004353)2.92984826
53Skin nodule (HP:0200036)2.91167552
54Ketoacidosis (HP:0001993)2.86772716
55Delayed CNS myelination (HP:0002188)2.86149090
56Tubular atrophy (HP:0000092)2.83397497
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80644465
58Abnormality of polysaccharide metabolism (HP:0011012)2.80644465
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80644465
60Glycosuria (HP:0003076)2.78984825
61Abnormality of urine glucose concentration (HP:0011016)2.78984825
62Hypoalbuminemia (HP:0003073)2.77825073
63Abnormal albumin level (HP:0012116)2.77825073
64Nuclear cataract (HP:0100018)2.77436643
65Spontaneous abortion (HP:0005268)2.73747743
66Hepatocellular carcinoma (HP:0001402)2.72833741
67Gout (HP:0001997)2.71610653
68Abnormality of nucleobase metabolism (HP:0010932)2.70095122
69Potter facies (HP:0002009)2.65135688
70Facial shape deformation (HP:0011334)2.65135688
71Abnormality of serum amino acid levels (HP:0003112)2.63617181
72Metabolic acidosis (HP:0001942)2.62791852
73Bronchiectasis (HP:0002110)2.62155052
74Myocardial infarction (HP:0001658)2.60386964
75Abnormality of purine metabolism (HP:0004352)2.58650270
76Vascular calcification (HP:0004934)2.57756104
77Cerebral hemorrhage (HP:0001342)2.53857694
78Mitral stenosis (HP:0001718)2.49274013
79Abnormal gallbladder physiology (HP:0012438)2.48736681
80Cholecystitis (HP:0001082)2.48736681
81Amyloidosis (HP:0011034)2.46310549
82Acanthocytosis (HP:0001927)2.45875867
83Systemic lupus erythematosus (HP:0002725)2.45187829
84Lethargy (HP:0001254)2.40765588
85Abnormal gallbladder morphology (HP:0012437)2.40120948
86Irritability (HP:0000737)2.39613070
87Cholelithiasis (HP:0001081)2.38551740
88Hypochromic microcytic anemia (HP:0004840)2.38336412
89Spastic diplegia (HP:0001264)2.37244321
90Glomerulonephritis (HP:0000099)2.37194369
91Esophageal varix (HP:0002040)2.34836800
92Cerebral edema (HP:0002181)2.34324937
93Neonatal onset (HP:0003623)2.32471613
94Cardiovascular calcification (HP:0011915)2.32099212
95Fetal akinesia sequence (HP:0001989)2.31012281
96Zonular cataract (HP:0010920)2.30783182
97Malnutrition (HP:0004395)2.30523362
98Arthropathy (HP:0003040)2.29967205
99Occipital encephalocele (HP:0002085)2.28793142
100Abnormal pancreas size (HP:0012094)2.25839748
101Abnormal pupillary function (HP:0007686)2.25668922
102Progressive neurologic deterioration (HP:0002344)2.25662204
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25544718
104Dicarboxylic aciduria (HP:0003215)2.25544718
105Focal segmental glomerulosclerosis (HP:0000097)2.24526649
106Sensorimotor neuropathy (HP:0007141)2.22351742
107Hypokinesia (HP:0002375)2.20885551
108Prolonged neonatal jaundice (HP:0006579)2.20756710
109Hypothermia (HP:0002045)2.19927539
110Abnormality of vitamin B metabolism (HP:0004340)2.19609945
111Polycythemia (HP:0001901)2.14869246
112Congenital malformation of the right heart (HP:0011723)2.13622374
113Double outlet right ventricle (HP:0001719)2.13622374
114Unilateral renal agenesis (HP:0000122)2.13102896
115Orthostatic hypotension (HP:0001278)2.12324253
116Recurrent gram-negative bacterial infections (HP:0005420)2.11067591
117Vacuolated lymphocytes (HP:0001922)2.11019526
118Hypoglycemic seizures (HP:0002173)2.10785490
119Testicular neoplasm (HP:0010788)2.09977899
120Abnormality of the gallbladder (HP:0005264)2.09797604
121Diminished movement (HP:0002374)2.08271712
122Stage 5 chronic kidney disease (HP:0003774)2.05739671
123Limb hypertonia (HP:0002509)2.03556592
124Hemorrhage of the eye (HP:0011885)2.02515479
125Cardiomegaly (HP:0001640)2.02409268
126Abnormal glucose tolerance (HP:0001952)2.02223663
127Enlarged penis (HP:0000040)1.99564453
128Chronic bronchitis (HP:0004469)1.99073158
129Mesangial abnormality (HP:0001966)1.98711413
130Generalized aminoaciduria (HP:0002909)1.98270227
131Brushfield spots (HP:0001088)1.97645572
132Nephritis (HP:0000123)1.97167125
133Vomiting (HP:0002013)1.96616025
134Testicular atrophy (HP:0000029)1.96145370
135Abnormality of renal excretion (HP:0011036)1.96055335
136Glucose intolerance (HP:0000833)1.94249063
137Menorrhagia (HP:0000132)1.93713719
138Late onset (HP:0003584)1.92801704
139Abnormal cartilage morphology (HP:0002763)1.91635267
140Large for gestational age (HP:0001520)1.91417390
141Hyperphosphaturia (HP:0003109)1.88879223
142Abnormality of vitamin metabolism (HP:0100508)1.88749699
143Peritonitis (HP:0002586)1.88314166
144Infertility (HP:0000789)1.86572785
145Thrombophlebitis (HP:0004418)1.85127105
146Congenital sensorineural hearing impairment (HP:0008527)1.84739397
147Glomerulosclerosis (HP:0000096)1.84476760
148Pancreatic fibrosis (HP:0100732)1.84305720
149Abnormal urine output (HP:0012590)1.82548165
150Pancreatitis (HP:0001733)1.82099296
151Postural tremor (HP:0002174)1.79146776
152Rickets (HP:0002748)1.78809783
153Nasal polyposis (HP:0100582)1.78081097
154Dysostosis multiplex (HP:0000943)1.77874250
155Morphological abnormality of the pyramidal tract (HP:0002062)1.77855620
156Hypoplasia of the uterus (HP:0000013)1.77506346
157Akinesia (HP:0002304)1.77363363
158Stroke (HP:0001297)1.77258636
159Back pain (HP:0003418)1.77084576
160Nephronophthisis (HP:0000090)1.76851151
161Status epilepticus (HP:0002133)1.76224698
162Abnormality of proline metabolism (HP:0010907)1.76076926
163Hydroxyprolinuria (HP:0003080)1.76076926
164Polyuria (HP:0000103)1.76009560
165Abnormality of liposaccharide metabolism (HP:0010968)1.75907862
166Abnormality of glycosphingolipid metabolism (HP:0004343)1.75907862
167Abnormality of glycolipid metabolism (HP:0010969)1.75907862
168Poikilocytosis (HP:0004447)1.75810979
169Hypotension (HP:0002615)1.75112899
170Enlarged kidneys (HP:0000105)1.74668794
171Male infertility (HP:0003251)1.74146052
172Hyperinsulinemic hypoglycemia (HP:0000825)1.73439856
173Pheochromocytoma (HP:0002666)1.72545913
174Abnormality of dentin (HP:0010299)1.71676453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.14800708
2TRPM73.88671830
3MST43.52880996
4SIK13.52878396
5MAP2K43.45017412
6ERN13.36883521
7FGFR43.26130768
8PHKG22.53699820
9PHKG12.53699820
10TESK12.34071143
11ERBB42.33612207
12MAP3K122.30119674
13CSNK1G32.22115021
14TRIB32.20665672
15LIMK12.20544362
16NTRK32.15977604
17MST1R2.09509241
18IRAK32.04730218
19CSNK1G22.02277317
20ERBB32.01172971
21CSNK1G11.98417153
22TAOK31.89080928
23MAPKAPK51.86789097
24PKN21.84026355
25EPHA21.80426788
26MAPKAPK31.79746723
27TIE11.75649961
28INSRR1.74208859
29MAP3K41.69056036
30PTK61.68537384
31RET1.66317978
32STK31.64775636
33FRK1.56534874
34RIPK11.54521871
35TYK21.50446654
36FGFR21.48620938
37TTN1.47321621
38PTK21.42779869
39MAP4K21.41172711
40DAPK21.40593747
41PRKCE1.39647216
42MYLK1.38647366
43EPHA31.37600830
44LATS11.36507447
45PIK3CG1.35356345
46GRK61.34986816
47ACVR1B1.34222227
48PRKG21.26875563
49WNK31.23996834
50CAMK2D1.21274136
51PINK11.19199006
52ADRBK21.16796088
53MAP2K71.15795602
54DDR21.12426454
55MAP3K91.10416641
56ABL21.09948324
57FER1.08212202
58STK241.05946206
59GRK51.04525726
60STK41.03987048
61TGFBR21.00549840
62KSR20.99806770
63CAMK1G0.97183210
64MAP3K110.94812045
65MAPK110.91858918
66EPHA40.90518429
67PRKCI0.88481030
68PDK30.87759636
69PDK40.87759636
70CAMK2G0.87243891
71MAP3K70.86303143
72FLT30.85862442
73PRKCZ0.84752257
74JAK20.83981151
75LMTK20.81172916
76LATS20.78623132
77CAMK1D0.77804760
78NEK90.77438151
79PDPK10.76597409
80WNK40.75459651
81CASK0.75111065
82MAP3K130.74869321
83BMPR20.74793148
84MAP3K20.74124782
85PRKAA20.73541321
86CDC42BPA0.73498118
87ERBB20.73324815
88MAP2K10.72181432
89NLK0.72139426
90TYRO30.69881751
91NTRK10.67871839
92PIK3CA0.66845508
93MAP2K30.66769023
94KDR0.66322362
95PRKACG0.64524790
96PNCK0.63958872
97OXSR10.63664584
98JAK10.63416709
99MET0.63078843
100PDGFRA0.62554313
101PTK2B0.62229179
102PAK30.61892296
103RPS6KB20.60780882
104MAP3K10.60379401
105EPHB10.60305922
106ROCK10.58820174
107GSK3A0.57285987
108IRAK10.57181091
109MAPK40.56880780
110SGK30.56738296
111ARAF0.56664002
112MAP2K60.56146213
113STK380.55673534
114CAMK2A0.54468644
115IGF1R0.54423824
116PDK10.49411446
117CSK0.49232574
118GRK10.48566022
119MAPK120.48172778
120ICK0.48069714
121TBK10.47426017
122AKT30.45355810
123MAP3K30.45352905
124EIF2AK10.45174801
125CDK60.44723414
126HIPK20.44512563
127PAK40.43880587
128MUSK0.42628708
129PRKCG0.42180097
130PRKAA10.42159928
131SGK4940.40808419
132SGK2230.40808419
133EGFR0.40451099
134CAMK2B0.40231454
135SGK20.40139127
136FGFR30.39637050
137ILK0.38598667
138STK390.38342074
139CAMKK20.37881459
140MINK10.37814126
141EPHB20.37412676
142DAPK10.37118482
143MKNK20.36226375
144MAPK150.35233330
145STK38L0.34572979
146ROCK20.34349160
147PRKCQ0.33996773
148CHUK0.33837283
149PRKG10.31743973
150BMX0.30169139
151DAPK30.27977077
152PRKACA0.27575648
153PRKCA0.26815360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.20671013
2Nitrogen metabolism_Homo sapiens_hsa009103.64043354
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17308801
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11171381
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.83425054
6Arginine biosynthesis_Homo sapiens_hsa002202.83030841
7Tryptophan metabolism_Homo sapiens_hsa003802.80942067
8Complement and coagulation cascades_Homo sapiens_hsa046102.59583380
9Fatty acid degradation_Homo sapiens_hsa000712.53904854
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45544112
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.37374114
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30774042
13Histidine metabolism_Homo sapiens_hsa003402.26727439
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18870014
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.17716008
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11013387
17Chemical carcinogenesis_Homo sapiens_hsa052042.10546366
18Propanoate metabolism_Homo sapiens_hsa006402.08109623
19Butanoate metabolism_Homo sapiens_hsa006502.06060421
20Phenylalanine metabolism_Homo sapiens_hsa003602.05587770
21Peroxisome_Homo sapiens_hsa041461.95969977
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91703638
23Tyrosine metabolism_Homo sapiens_hsa003501.89712892
24Fatty acid metabolism_Homo sapiens_hsa012121.89556236
25PPAR signaling pathway_Homo sapiens_hsa033201.87595880
26beta-Alanine metabolism_Homo sapiens_hsa004101.67225891
27Caffeine metabolism_Homo sapiens_hsa002321.66703039
28Pyruvate metabolism_Homo sapiens_hsa006201.66191174
29* Retinol metabolism_Homo sapiens_hsa008301.61400086
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60734011
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56612546
32Bile secretion_Homo sapiens_hsa049761.55594809
33Sulfur metabolism_Homo sapiens_hsa009201.51039781
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50717575
35Staphylococcus aureus infection_Homo sapiens_hsa051501.45836760
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44918356
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.44550508
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43921952
39Other glycan degradation_Homo sapiens_hsa005111.41179720
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.40221598
41Fatty acid elongation_Homo sapiens_hsa000621.39506884
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37003821
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.35968168
44Selenocompound metabolism_Homo sapiens_hsa004501.35389077
45Starch and sucrose metabolism_Homo sapiens_hsa005001.22165939
46Arachidonic acid metabolism_Homo sapiens_hsa005901.20216069
47Fat digestion and absorption_Homo sapiens_hsa049751.16177729
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15914256
49Carbon metabolism_Homo sapiens_hsa012001.11211618
50ABC transporters_Homo sapiens_hsa020101.09806358
51Insulin secretion_Homo sapiens_hsa049111.09702614
52Sphingolipid metabolism_Homo sapiens_hsa006001.04964565
53Biosynthesis of amino acids_Homo sapiens_hsa012301.04675787
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00370617
55Folate biosynthesis_Homo sapiens_hsa007900.94551872
56Steroid biosynthesis_Homo sapiens_hsa001000.91995987
57Protein export_Homo sapiens_hsa030600.91704879
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87876220
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87331107
60Vitamin B6 metabolism_Homo sapiens_hsa007500.86503107
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84600714
62Vitamin digestion and absorption_Homo sapiens_hsa049770.80544847
63Arginine and proline metabolism_Homo sapiens_hsa003300.80386353
64Glutathione metabolism_Homo sapiens_hsa004800.79808250
65Fatty acid biosynthesis_Homo sapiens_hsa000610.77317275
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77226287
67Glycerolipid metabolism_Homo sapiens_hsa005610.75071315
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.73807646
69Collecting duct acid secretion_Homo sapiens_hsa049660.72881345
70Ether lipid metabolism_Homo sapiens_hsa005650.72612297
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67290427
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66690042
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65914766
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65548942
75Vibrio cholerae infection_Homo sapiens_hsa051100.64605216
76Lysine degradation_Homo sapiens_hsa003100.64406504
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.63784867
78Sulfur relay system_Homo sapiens_hsa041220.62126871
79Lysosome_Homo sapiens_hsa041420.56686458
80Pancreatic secretion_Homo sapiens_hsa049720.53425399
81Cocaine addiction_Homo sapiens_hsa050300.51682611
82Protein digestion and absorption_Homo sapiens_hsa049740.51245198
83Pentose phosphate pathway_Homo sapiens_hsa000300.48559733
84Circadian rhythm_Homo sapiens_hsa047100.46234566
85* Metabolic pathways_Homo sapiens_hsa011000.41662072
86Prion diseases_Homo sapiens_hsa050200.38366661
87N-Glycan biosynthesis_Homo sapiens_hsa005100.37034949
88Serotonergic synapse_Homo sapiens_hsa047260.35877122
89Tight junction_Homo sapiens_hsa045300.35104978
90Renin secretion_Homo sapiens_hsa049240.33106899
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30716138
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.26559478
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26086857
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26083953
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22763499
96Insulin resistance_Homo sapiens_hsa049310.22498950
97Glucagon signaling pathway_Homo sapiens_hsa049220.22268460
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.19841063
99One carbon pool by folate_Homo sapiens_hsa006700.19246210
100Ovarian steroidogenesis_Homo sapiens_hsa049130.17637409
101Type II diabetes mellitus_Homo sapiens_hsa049300.16840364
102Galactose metabolism_Homo sapiens_hsa000520.16824473
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.16241255
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15650929
105Fructose and mannose metabolism_Homo sapiens_hsa000510.13827467
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09414072
107Synaptic vesicle cycle_Homo sapiens_hsa047210.08149781
108Linoleic acid metabolism_Homo sapiens_hsa005910.06059983
109Parkinsons disease_Homo sapiens_hsa050120.05314793
110Amphetamine addiction_Homo sapiens_hsa050310.05124823
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03678843
112AMPK signaling pathway_Homo sapiens_hsa041520.01363573
113Thyroid hormone synthesis_Homo sapiens_hsa049180.00915871
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1601465
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1545562
116Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1544030
117Mineral absorption_Homo sapiens_hsa04978-0.1505281
118Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1451610
119Dopaminergic synapse_Homo sapiens_hsa04728-0.1236881
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1125834
121Amoebiasis_Homo sapiens_hsa05146-0.0977663
122Oxidative phosphorylation_Homo sapiens_hsa00190-0.0884014
123Renin-angiotensin system_Homo sapiens_hsa04614-0.0851253
124Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0787395
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0524750
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0506547
127African trypanosomiasis_Homo sapiens_hsa05143-0.0076792

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