ALDH1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)8.29639025
2nuclear pore organization (GO:0006999)7.37441988
3synapsis (GO:0007129)7.01642808
4mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)6.34233706
5pore complex assembly (GO:0046931)6.25233088
6metanephric mesenchyme development (GO:0072075)5.95646891
7kidney mesenchyme development (GO:0072074)5.93884164
8DNA replication checkpoint (GO:0000076)5.56387187
9DNA unwinding involved in DNA replication (GO:0006268)5.48423990
10regulation of translational fidelity (GO:0006450)5.48379784
11embryonic skeletal joint morphogenesis (GO:0060272)5.34648477
12chondrocyte proliferation (GO:0035988)5.24740604
13metanephros development (GO:0001656)5.20537072
14meiotic chromosome segregation (GO:0045132)5.14099920
15DNA synthesis involved in DNA repair (GO:0000731)5.13388626
16* proximal/distal pattern formation (GO:0009954)5.12010613
17chromosome organization involved in meiosis (GO:0070192)5.08616006
18mitotic nuclear envelope disassembly (GO:0007077)5.02131528
19organ induction (GO:0001759)5.00505333
20mitotic chromosome condensation (GO:0007076)4.99563785
21DNA replication initiation (GO:0006270)4.93881543
22regulation of RNA export from nucleus (GO:0046831)4.88461132
23membrane disassembly (GO:0030397)4.72792845
24nuclear envelope disassembly (GO:0051081)4.72792845
25DNA methylation involved in gamete generation (GO:0043046)4.71632417
26mitotic sister chromatid segregation (GO:0000070)4.67981617
27regulation of histone H3-K4 methylation (GO:0051569)4.60794053
28sister chromatid segregation (GO:0000819)4.59445923
29regulation of histone H3-K27 methylation (GO:0061085)4.54640439
30resolution of meiotic recombination intermediates (GO:0000712)4.54386030
31DNA topological change (GO:0006265)4.46203977
32mesenchymal to epithelial transition (GO:0060231)4.45893108
33regulation of T-helper 1 cell differentiation (GO:0045625)4.45746471
34cell proliferation involved in metanephros development (GO:0072203)4.38123102
35G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.36654615
36outer ear morphogenesis (GO:0042473)4.30718014
37positive regulation of metanephros development (GO:0072216)4.30348234
38DNA strand elongation involved in DNA replication (GO:0006271)4.27793897
39regulation of nucleobase-containing compound transport (GO:0032239)4.24398198
40DNA strand elongation (GO:0022616)4.14617130
41positive regulation of type 2 immune response (GO:0002830)4.11587706
42mesenchymal cell differentiation involved in kidney development (GO:0072161)4.10187935
43mesenchymal cell differentiation involved in renal system development (GO:2001012)4.10187935
44male meiosis I (GO:0007141)4.05423661
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.04088066
46protoporphyrinogen IX metabolic process (GO:0046501)4.02324670
47negative regulation of erythrocyte differentiation (GO:0045647)4.00122218
48regulation of histone H3-K9 methylation (GO:0051570)3.91798655
49histone H3-K9 demethylation (GO:0033169)3.91460444
50cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.90339880
51synaptonemal complex assembly (GO:0007130)3.90177783
52gas transport (GO:0015669)3.87869771
53protein heterotrimerization (GO:0070208)3.87729852
54male meiosis (GO:0007140)3.85176544
55branching involved in ureteric bud morphogenesis (GO:0001658)3.79329931
56formation of translation preinitiation complex (GO:0001731)3.78838689
57regulation of organ formation (GO:0003156)3.78722293
58collagen fibril organization (GO:0030199)3.75760867
59cell proliferation involved in kidney development (GO:0072111)3.72261789
60negative regulation of fatty acid transport (GO:2000192)3.68955594
61regulation of histone methylation (GO:0031060)3.68078783
62positive regulation of T cell apoptotic process (GO:0070234)3.62024349
63oxygen transport (GO:0015671)3.60529141
64positive regulation of macrophage activation (GO:0043032)3.58688454
65definitive hemopoiesis (GO:0060216)3.56304090
66chromosome segregation (GO:0007059)3.53353577
67telomere maintenance via semi-conservative replication (GO:0032201)3.52670747
68purine nucleobase biosynthetic process (GO:0009113)3.52336565
69negative regulation of histone methylation (GO:0031061)3.49673140
70nuclear envelope organization (GO:0006998)3.47407285
71regulation of apoptotic process involved in morphogenesis (GO:1902337)3.46064571
72mitotic sister chromatid cohesion (GO:0007064)3.44564974
73protoporphyrinogen IX biosynthetic process (GO:0006782)3.43959685
74folic acid-containing compound biosynthetic process (GO:0009396)3.42243786
75positive regulation of chondrocyte differentiation (GO:0032332)3.41698507
76* forelimb morphogenesis (GO:0035136)3.40948425
77chromosome condensation (GO:0030261)3.38622056
78* embryonic forelimb morphogenesis (GO:0035115)3.38474786
79proline biosynthetic process (GO:0006561)3.38331558
80DNA packaging (GO:0006323)3.36944211
81meiotic nuclear division (GO:0007126)3.36328427
82regulation of metanephros development (GO:0072215)3.36028502
83positive regulation of natural killer cell differentiation (GO:0032825)3.35538631
84meiosis I (GO:0007127)3.35300705
85glomerular basement membrane development (GO:0032836)3.34302408
86creatine metabolic process (GO:0006600)3.32632717
87regulation of heart morphogenesis (GO:2000826)3.31521343
88regulation of immunoglobulin secretion (GO:0051023)3.30258419
89IMP biosynthetic process (GO:0006188)3.28569482
90regulation of mitotic spindle organization (GO:0060236)3.28521613
91synaptonemal complex organization (GO:0070193)3.26319392
92regulation of glomerulus development (GO:0090192)3.25935859
93positive regulation of glomerulus development (GO:0090193)3.23468651
94tRNA aminoacylation for protein translation (GO:0006418)3.23332678
95telomere maintenance via recombination (GO:0000722)3.22011321
96positive regulation of mesonephros development (GO:0061213)3.21718552
97protein export from nucleus (GO:0006611)3.21614216
98* neural crest cell development (GO:0014032)3.21513694
99growth hormone receptor signaling pathway (GO:0060396)3.21500731
100positive regulation of male gonad development (GO:2000020)3.20973270
101DNA conformation change (GO:0071103)3.20210436
102sister chromatid cohesion (GO:0007062)3.19365104
103meiotic cell cycle process (GO:1903046)3.19209140
104homocysteine metabolic process (GO:0050667)3.17742708
105mitotic recombination (GO:0006312)3.16453010
106regulation of translational elongation (GO:0006448)3.16228069
107nucleobase biosynthetic process (GO:0046112)3.15783106
108mesenchyme morphogenesis (GO:0072132)3.15589546
109regulation of mesonephros development (GO:0061217)3.15574597
110craniofacial suture morphogenesis (GO:0097094)3.15236449
111regulation of sister chromatid cohesion (GO:0007063)3.14750339
112lymph vessel development (GO:0001945)3.14385964
113protein localization to chromosome, centromeric region (GO:0071459)3.14200539
114erythrocyte maturation (GO:0043249)3.13603665
115middle ear morphogenesis (GO:0042474)3.13162774
116regulation of macrophage cytokine production (GO:0010935)3.12666596
117oxaloacetate metabolic process (GO:0006107)3.10937306
118positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.10903887
119positive regulation of histone methylation (GO:0031062)3.09778992
120amino acid activation (GO:0043038)3.09398949
121tRNA aminoacylation (GO:0043039)3.09398949
122negative regulation of potassium ion transmembrane transport (GO:1901380)3.08077830
123regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.05888423
124granulocyte differentiation (GO:0030851)3.05496672
125DNA duplex unwinding (GO:0032508)3.05361443
126protein localization to kinetochore (GO:0034501)3.04715895
127regulation of chromosome segregation (GO:0051983)3.03190284
128IMP metabolic process (GO:0046040)3.02784185
129oxidative phosphorylation (GO:0006119)3.02573064
130microtubule depolymerization (GO:0007019)3.01829978
131sequestering of actin monomers (GO:0042989)3.00587787
132positive regulation of cartilage development (GO:0061036)2.99821606
133valine metabolic process (GO:0006573)2.99208615
134negative regulation of chromosome segregation (GO:0051985)2.99005753
135positive regulation of chromosome segregation (GO:0051984)2.98269681
136mRNA transport (GO:0051028)2.98094255
137paraxial mesoderm development (GO:0048339)2.97599058
138positive regulation of histone H3-K4 methylation (GO:0051571)2.97174056
139mitotic spindle assembly checkpoint (GO:0007094)2.96595254
140embryonic skeletal system morphogenesis (GO:0048704)2.96093088
141positive regulation of chemokine secretion (GO:0090197)2.95684049
142regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94920018
143basement membrane organization (GO:0071711)2.94309211
144DNA geometric change (GO:0032392)2.93575280
145tetrahydrofolate metabolic process (GO:0046653)2.91985988
146COPI coating of Golgi vesicle (GO:0048205)2.91848566
147Golgi transport vesicle coating (GO:0048200)2.91848566
148intra-S DNA damage checkpoint (GO:0031573)2.91423600
149spindle assembly checkpoint (GO:0071173)2.90407061
150cellular response to growth hormone stimulus (GO:0071378)2.89134668
151chromosome organization (GO:0051276)2.88792346
152negative regulation of mitotic sister chromatid separation (GO:2000816)2.88123621
153negative regulation of sister chromatid segregation (GO:0033046)2.88123621
154negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88123621
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88123621
156negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88123621
157uterus development (GO:0060065)2.87460926
158positive regulation of cell adhesion mediated by integrin (GO:0033630)2.87075863
159* mesenchymal cell development (GO:0014031)2.85590633
160embryonic cranial skeleton morphogenesis (GO:0048701)2.85197606
161developmental induction (GO:0031128)2.83475369
162embryonic digit morphogenesis (GO:0042733)2.82884468
163positive regulation of T-helper cell differentiation (GO:0045624)2.80609927
164regulation of male gonad development (GO:2000018)2.80133558
165regulation of activation of Janus kinase activity (GO:0010533)2.79448357
166embryonic viscerocranium morphogenesis (GO:0048703)2.77562330
167regulation of T-helper 2 cell differentiation (GO:0045628)2.76225640
168mesonephros development (GO:0001823)2.76038521
169regulation of stem cell maintenance (GO:2000036)2.75786467
170hippo signaling (GO:0035329)2.75647898
171regulation of transforming growth factor beta2 production (GO:0032909)2.75047185
172sequestering of extracellular ligand from receptor (GO:0035581)2.74682642
173cardiac muscle cell proliferation (GO:0060038)2.73645158
174cell-cell signaling involved in cell fate commitment (GO:0045168)2.72588006
175positive regulation of lymphocyte apoptotic process (GO:0070230)2.72054050
176cell differentiation involved in metanephros development (GO:0072202)2.70165354
177positive regulation of endothelial cell apoptotic process (GO:2000353)2.69488095
178glial cell migration (GO:0008347)2.69058309
179axon extension involved in axon guidance (GO:0048846)2.67730348
180neuron projection extension involved in neuron projection guidance (GO:1902284)2.67730348
181adrenal gland development (GO:0030325)2.67283668
182glomerulus development (GO:0032835)2.67233549
183aorta morphogenesis (GO:0035909)2.65956460
184regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.64547237
185skeletal muscle organ development (GO:0060538)2.63091812
186positive regulation of monocyte chemotaxis (GO:0090026)2.61007777
187collagen metabolic process (GO:0032963)2.60716259
188negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.60151523
189regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59792294
190diaphragm development (GO:0060539)2.59568421
191natural killer cell differentiation (GO:0001779)2.59332490
192regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.57741169
193planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57330649
194single fertilization (GO:0007338)2.57237757
195skeletal system morphogenesis (GO:0048705)2.57171585
196nephron epithelium morphogenesis (GO:0072088)2.56828165
197nephron tubule morphogenesis (GO:0072078)2.56828165
198collagen catabolic process (GO:0030574)2.55098165
199positive regulation of protein kinase C signaling (GO:0090037)2.53018247
200response to prostaglandin E (GO:0034695)2.52109838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.22044114
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.97056301
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80930010
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30198997
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.23541259
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.14226029
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.09877890
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01046232
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.01013157
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.98149068
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.95989405
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.85465543
13NCOR1_26117541_ChIP-Seq_K562_Human2.76892476
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72813204
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70143422
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58716023
17CLOCK_20551151_ChIP-Seq_293T_Human2.57869734
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56384452
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.53958866
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47612505
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.45808311
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44463680
23GATA1_19941826_ChIP-Seq_K562_Human2.42698598
24WT1_19549856_ChIP-ChIP_CCG9911_Human2.40034679
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.38403171
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35961102
27GATA1_22025678_ChIP-Seq_K562_Human2.35304278
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35073765
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30146101
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.28099100
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27772286
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.24696676
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24481460
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22600182
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.22418047
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.20915698
37XRN2_22483619_ChIP-Seq_HELA_Human2.19811127
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17280117
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16088528
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15726838
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14617875
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11645796
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11343243
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.09761717
45MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08041906
46* EED_16625203_ChIP-ChIP_MESCs_Mouse2.06802867
47CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01849493
48E2F7_22180533_ChIP-Seq_HELA_Human10.7215141
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96123696
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.95063508
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94881932
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83468175
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80269869
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78595173
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77755191
56BRD4_25478319_ChIP-Seq_HGPS_Human1.77445825
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77326489
58TTF2_22483619_ChIP-Seq_HELA_Human1.75591476
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75015316
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.73473816
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73044473
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71875089
63DCP1A_22483619_ChIP-Seq_HELA_Human1.71788195
64CJUN_26792858_Chip-Seq_BT549_Human1.71427219
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.71312173
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71294748
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70559493
68GATA2_19941826_ChIP-Seq_K562_Human1.69929128
69* EP300_21415370_ChIP-Seq_HL-1_Mouse1.69279316
70KDM5A_27292631_Chip-Seq_BREAST_Human1.65698973
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65572550
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.65050889
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63579200
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60417838
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57322056
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56847413
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.56511459
78* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53900031
79* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53900031
80* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50842963
81CIITA_25753668_ChIP-Seq_RAJI_Human1.46253102
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45011270
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44173280
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41973889
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41973889
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41577108
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41577108
88MYC_22102868_ChIP-Seq_BL_Human1.40213690
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39320052
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.38901122
91* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37038714
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37006879
93TP53_18474530_ChIP-ChIP_U2OS_Human1.34585440
94* IRF8_27001747_Chip-Seq_BMDM_Mouse1.34446009
95GABP_19822575_ChIP-Seq_HepG2_Human1.32425133
96* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31736180
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30785432
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29878845
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29854602
100VDR_24787735_ChIP-Seq_THP-1_Human1.29714200
101SPI1_23127762_ChIP-Seq_K562_Human1.29517443
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29422131
103SCL_19346495_ChIP-Seq_HPC-7_Human1.28766129
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27510368
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27164571
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.26860375
107* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25310434
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23613659
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22156827
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21630477
111FOXP3_21729870_ChIP-Seq_TREG_Human1.20429517
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20100793
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19367640
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19367640
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19367640
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19302048
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19290533
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19033095
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17534143
120TFEB_21752829_ChIP-Seq_HELA_Human1.16046731
121* CBX2_27304074_Chip-Seq_ESCs_Mouse1.16023863
122ISL1_27105846_Chip-Seq_CPCs_Mouse1.15442392
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.15401152
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15178157
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15110908
126TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14981374
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13917541
128KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13285935
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13063355
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12920081
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12868534
132TBX20_22328084_ChIP-Seq_HEART_Mouse1.12665664
133TBX20_22080862_ChIP-Seq_HEART_Mouse1.12665664
134VDR_23849224_ChIP-Seq_CD4+_Human1.10402378
135GABP_17652178_ChIP-ChIP_JURKAT_Human1.10285145
136RNF2_27304074_Chip-Seq_ESCs_Mouse1.08978797
137POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08625611
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.08462159
139ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08385043
140ELK1_19687146_ChIP-ChIP_HELA_Human1.07931143
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07858490
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07180626
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06966416
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05916552
145ZNF263_19887448_ChIP-Seq_K562_Human1.05649197
146TP53_22127205_ChIP-Seq_IMR90_Human1.05586109
147CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05418003
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05028516
149EZH2_27304074_Chip-Seq_ESCs_Mouse1.04930295
150NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04345986
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03982457
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03150195
153NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02390099
154* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01312745
155TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01062466
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00360790
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00102645
158STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99585182
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99129195
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.99105350
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98933282
162STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98372988
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98371206
164ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97113235
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96846871
166E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96321741
167CHD1_26751641_Chip-Seq_LNCaP_Human0.96097257
168TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95994820
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94503865
170TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93723841
171SOX2_20726797_ChIP-Seq_SW620_Human0.93598977
172* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93205827
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92795240
174GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92521569
175* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91445836
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90978116
177SA1_22415368_ChIP-Seq_MEFs_Mouse0.90956690
178AR_21909140_ChIP-Seq_LNCAP_Human0.90330081
179SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90185284
180NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90108468
181PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87610560
182PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86749571
183* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85529342
184YY1_21170310_ChIP-Seq_MESCs_Mouse0.85402355
185SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84945629
186GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83275245
187PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79079734
188KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77841241
189FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77701023
190GATA6_21074721_ChIP-Seq_CACO-2_Human0.76870838
191VDR_21846776_ChIP-Seq_THP-1_Human0.76155496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.25698452
2MP0005503_abnormal_tendon_morphology4.43680410
3MP0008995_early_reproductive_senescence4.43068073
4MP0005623_abnormal_meninges_morphology4.08661947
5MP0010094_abnormal_chromosome_stability3.83267731
6MP0003111_abnormal_nucleus_morphology3.82484879
7MP0008057_abnormal_DNA_replication3.70165385
8MP0004957_abnormal_blastocyst_morpholog3.49305183
9MP0004147_increased_porphyrin_level3.46733489
10* MP0003942_abnormal_urinary_system3.37263936
11MP0008058_abnormal_DNA_repair3.35869031
12MP0000534_abnormal_ureter_morphology3.23912373
13MP0005451_abnormal_body_composition3.21497147
14MP0003693_abnormal_embryo_hatching3.17311757
15MP0003123_paternal_imprinting2.81833324
16MP0004272_abnormal_basement_membrane2.80920035
17MP0010030_abnormal_orbit_morphology2.68860141
18MP0003122_maternal_imprinting2.68817354
19MP0003705_abnormal_hypodermis_morpholog2.68292108
20MP0009697_abnormal_copulation2.66964511
21MP0003077_abnormal_cell_cycle2.65908583
22MP0009053_abnormal_anal_canal2.63875383
23MP0005275_abnormal_skin_tensile2.56028807
24MP0003656_abnormal_erythrocyte_physiolo2.52807484
25MP0008877_abnormal_DNA_methylation2.49332472
26MP0003786_premature_aging2.47797472
27MP0004233_abnormal_muscle_weight2.31813775
28MP0009250_abnormal_appendicular_skeleto2.30799044
29MP0001661_extended_life_span2.28610418
30MP0002210_abnormal_sex_determination2.18431016
31MP0003279_aneurysm2.16961138
32* MP0003385_abnormal_body_wall2.11689081
33* MP0008932_abnormal_embryonic_tissue2.02749024
34MP0001879_abnormal_lymphatic_vessel2.01105639
35MP0006054_spinal_hemorrhage1.99987574
36MP0003941_abnormal_skin_development1.98146189
37MP0001929_abnormal_gametogenesis1.97087482
38MP0001730_embryonic_growth_arrest1.96194948
39* MP0002282_abnormal_trachea_morphology1.92135182
40MP0001545_abnormal_hematopoietic_system1.91372868
41MP0005397_hematopoietic_system_phenotyp1.91372868
42MP0002932_abnormal_joint_morphology1.83792589
43MP0002009_preneoplasia1.83693932
44MP0001348_abnormal_lacrimal_gland1.82176895
45MP0001346_abnormal_lacrimal_gland1.80400673
46MP0004145_abnormal_muscle_electrophysio1.79063129
47MP0005508_abnormal_skeleton_morphology1.78744774
48MP0002877_abnormal_melanocyte_morpholog1.75755743
49MP0000350_abnormal_cell_proliferation1.73180793
50* MP0002249_abnormal_larynx_morphology1.72963774
51MP0001958_emphysema1.71753618
52MP0000767_abnormal_smooth_muscle1.71109755
53MP0003718_maternal_effect1.67845345
54MP0003121_genomic_imprinting1.64307468
55MP0001672_abnormal_embryogenesis/_devel1.62627138
56MP0005380_embryogenesis_phenotype1.62627138
57MP0003115_abnormal_respiratory_system1.61559320
58* MP0001697_abnormal_embryo_size1.57134943
59MP0003984_embryonic_growth_retardation1.55394460
60MP0001145_abnormal_male_reproductive1.54056743
61MP0002148_abnormal_hypersensitivity_rea1.52347720
62MP0002088_abnormal_embryonic_growth/wei1.51391999
63MP0010368_abnormal_lymphatic_system1.49518168
64MP0002115_abnormal_skeleton_extremities1.48358873
65MP0000653_abnormal_sex_gland1.46963112
66MP0000313_abnormal_cell_death1.46822693
67MP0000685_abnormal_immune_system1.46374542
68MP0005367_renal/urinary_system_phenotyp1.45945036
69MP0000516_abnormal_urinary_system1.45945036
70MP0003698_abnormal_male_reproductive1.43364281
71MP0006035_abnormal_mitochondrial_morpho1.41405406
72* MP0002080_prenatal_lethality1.40607903
73MP0006036_abnormal_mitochondrial_physio1.39346565
74MP0002132_abnormal_respiratory_system1.39175637
75MP0003221_abnormal_cardiomyocyte_apopto1.38621507
76MP0004036_abnormal_muscle_relaxation1.37881929
77MP0002396_abnormal_hematopoietic_system1.37614282
78MP0000733_abnormal_muscle_development1.35434354
79MP0005083_abnormal_biliary_tract1.32661936
80MP0000049_abnormal_middle_ear1.32518839
81MP0002163_abnormal_gland_morphology1.32463024
82MP0001915_intracranial_hemorrhage1.29412415
83MP0003646_muscle_fatigue1.28943546
84MP0003959_abnormal_lean_body1.25146445
85* MP0002109_abnormal_limb_morphology1.24963115
86MP0004084_abnormal_cardiac_muscle1.23473823
87* MP0002086_abnormal_extraembryonic_tissu1.23374722
88MP0003699_abnormal_female_reproductive1.22284081
89MP0002269_muscular_atrophy1.21636360
90MP0005023_abnormal_wound_healing1.20869043
91MP0005410_abnormal_fertilization1.20667982
92MP0010352_gastrointestinal_tract_polyps1.20184892
93MP0002160_abnormal_reproductive_system1.18090377
94MP0001835_abnormal_antigen_presentation1.17063170
95MP0001849_ear_inflammation1.16301501
96MP0002139_abnormal_hepatobiliary_system1.16198602
97MP0008007_abnormal_cellular_replicative1.11453785
98MP0002108_abnormal_muscle_morphology1.10640990
99MP0002161_abnormal_fertility/fecundity1.08660134
100MP0000428_abnormal_craniofacial_morphol1.07156901
101MP0005390_skeleton_phenotype1.06176227
102MP0002233_abnormal_nose_morphology1.05576672
103MP0005248_abnormal_Harderian_gland1.05548674
104MP0003566_abnormal_cell_adhesion1.04578330
105MP0002114_abnormal_axial_skeleton1.03873463
106MP0001727_abnormal_embryo_implantation1.03854357
107MP0003950_abnormal_plasma_membrane1.02288610
108MP0001175_abnormal_lung_morphology1.01226930
109* MP0002084_abnormal_developmental_patter1.01200883
110MP0005058_abnormal_lysosome_morphology1.01102048
111MP0000372_irregular_coat_pigmentation0.98456859
112MP0003755_abnormal_palate_morphology0.97161244
113* MP0000163_abnormal_cartilage_morphology0.97104458
114MP0009278_abnormal_bone_marrow0.96077818
115MP0002938_white_spotting0.95125592
116* MP0002085_abnormal_embryonic_tissue0.95110390
117MP0002113_abnormal_skeleton_development0.94993818
118MP0004808_abnormal_hematopoietic_stem0.94464707
119MP0003091_abnormal_cell_migration0.93213851
120MP0008775_abnormal_heart_ventricle0.92086528
121MP0000537_abnormal_urethra_morphology0.91384786
122MP0005171_absent_coat_pigmentation0.90968234
123* MP0003935_abnormal_craniofacial_develop0.90054197
124MP0000358_abnormal_cell_content/0.89887057
125MP0004185_abnormal_adipocyte_glucose0.89750404
126MP0002166_altered_tumor_susceptibility0.88703379
127MP0003448_altered_tumor_morphology0.88368802
128MP0002006_tumorigenesis0.88227549
129* MP0002135_abnormal_kidney_morphology0.88073805
130MP0002019_abnormal_tumor_incidence0.87952540
131MP0003436_decreased_susceptibility_to0.87805414
132* MP0001614_abnormal_blood_vessel0.87044612
133MP0002116_abnormal_craniofacial_bone0.86655386
134* MP0000703_abnormal_thymus_morphology0.86067217
135MP0005636_abnormal_mineral_homeostasis0.85852120
136* MP0003937_abnormal_limbs/digits/tail_de0.85690700
137MP0002128_abnormal_blood_circulation0.84097869
138MP0005389_reproductive_system_phenotype0.83666916
139MP0001119_abnormal_female_reproductive0.82714095
140MP0000747_muscle_weakness0.82210797
141MP0003567_abnormal_fetal_cardiomyocyte0.81053760
142MP0005076_abnormal_cell_differentiation0.80474851
143* MP0003936_abnormal_reproductive_system0.80111642
144MP0005187_abnormal_penis_morphology0.79406672
145MP0000432_abnormal_head_morphology0.77975020
146MP0000681_abnormal_thyroid_gland0.77972463
147MP0002092_abnormal_eye_morphology0.77840336
148MP0004883_abnormal_blood_vessel0.77617621
149MP0004134_abnormal_chest_morphology0.77083984
150MP0002295_abnormal_pulmonary_circulatio0.75969011
151MP0003943_abnormal_hepatobiliary_system0.75159787
152MP0002254_reproductive_system_inflammat0.73855075
153MP0002998_abnormal_bone_remodeling0.72681150
154MP0003315_abnormal_perineum_morphology0.72122262
155* MP0002925_abnormal_cardiovascular_devel0.71610930
156MP0000566_synostosis0.70703828
157* MP0010630_abnormal_cardiac_muscle0.70552828
158MP0006138_congestive_heart_failure0.70458073
159MP0005647_abnormal_sex_gland0.69515115
160* MP0000678_abnormal_parathyroid_gland0.69331583
161MP0005197_abnormal_uvea_morphology0.69324714
162MP0001533_abnormal_skeleton_physiology0.69175506
163MP0009115_abnormal_fat_cell0.68894419
164MP0003890_abnormal_embryonic-extraembry0.67258746
165MP0005257_abnormal_intraocular_pressure0.67039409
166MP0009703_decreased_birth_body0.66677556
167* MP0000266_abnormal_heart_morphology0.66657232
168MP0009785_altered_susceptibility_to0.66420421
169MP0009333_abnormal_splenocyte_physiolog0.66168439
170MP0000639_abnormal_adrenal_gland0.65846902
171MP0010307_abnormal_tumor_latency0.65518285
172MP0005330_cardiomyopathy0.65355536
173MP0000598_abnormal_liver_morphology0.64864716
174MP0001764_abnormal_homeostasis0.64642263
175MP0002970_abnormal_white_adipose0.64468122
176MP0002896_abnormal_bone_mineralization0.64449562
177MP0000609_abnormal_liver_physiology0.64064153
178MP0009764_decreased_sensitivity_to0.64005002
179MP0005408_hypopigmentation0.63783409
180MP0003186_abnormal_redox_activity0.63768166
181MP0005666_abnormal_adipose_tissue0.62640435
182MP0004197_abnormal_fetal_growth/weight/0.62209177

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)7.30473255
2Cholecystitis (HP:0001082)7.30473255
3Truncus arteriosus (HP:0001660)6.41320383
4Reticulocytosis (HP:0001923)5.15697736
5Hyperthyroidism (HP:0000836)4.99691470
6Protrusio acetabuli (HP:0003179)4.94071257
7Polycythemia (HP:0001901)4.79946687
8Bowel incontinence (HP:0002607)4.43517500
9Abnormal large intestine physiology (HP:0012700)4.31607436
10Chromsome breakage (HP:0040012)4.27155141
11Abnormality of reticulocytes (HP:0004312)4.26735178
12Ankyloglossia (HP:0010296)4.24860044
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10406420
14Birth length less than 3rd percentile (HP:0003561)3.93445630
15Renal duplication (HP:0000075)3.82599208
16Aortic dissection (HP:0002647)3.69373490
17Premature rupture of membranes (HP:0001788)3.67290325
18Cholelithiasis (HP:0001081)3.66805161
19Hypertensive crisis (HP:0100735)3.58080336
20Abnormality of dentin (HP:0010299)3.55685372
21Cortical dysplasia (HP:0002539)3.47448688
22Abnormality of cochlea (HP:0000375)3.43086945
23Shallow orbits (HP:0000586)3.37230276
24Abnormality of homocysteine metabolism (HP:0010919)3.34784609
25Homocystinuria (HP:0002156)3.34784609
26Abnormality of glycolysis (HP:0004366)3.34085564
27Atelectasis (HP:0100750)3.33602432
28Ulnar bowing (HP:0003031)3.31811403
29Seborrheic dermatitis (HP:0001051)3.30368374
30Hypoparathyroidism (HP:0000829)3.23336735
31Arterial tortuosity (HP:0005116)3.21936898
32Abnormality of the tricuspid valve (HP:0001702)3.18908345
33Abnormal gallbladder morphology (HP:0012437)3.18343096
34Acute myeloid leukemia (HP:0004808)3.12278858
35Increased nuchal translucency (HP:0010880)3.10591637
36Abnormal hemoglobin (HP:0011902)3.05427087
37Vertebral compression fractures (HP:0002953)3.01725232
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.01078968
39Short 4th metacarpal (HP:0010044)3.01078968
40Ileus (HP:0002595)2.97492743
41Abnormality of oral frenula (HP:0000190)2.96279814
42Broad metatarsal (HP:0001783)2.96002508
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.95738679
44Spinal cord lesions (HP:0100561)2.95248879
45Syringomyelia (HP:0003396)2.95248879
46Ankle contracture (HP:0006466)2.90808416
47Orthostatic hypotension (HP:0001278)2.90210342
48Peritonitis (HP:0002586)2.89088719
49Vascular tortuosity (HP:0004948)2.88802217
50Increased serum pyruvate (HP:0003542)2.87535541
51Poikilocytosis (HP:0004447)2.83340132
52Soft skin (HP:0000977)2.82553574
53Pulmonary artery stenosis (HP:0004415)2.82218595
54Aortic aneurysm (HP:0004942)2.80842127
55Short middle phalanx of the 5th finger (HP:0004220)2.79854840
56Dysmetric saccades (HP:0000641)2.79785566
57Broad toe (HP:0001837)2.79251876
58Abnormality of the gallbladder (HP:0005264)2.74945653
59Upper limb muscle weakness (HP:0003484)2.72557251
60Aplasia/Hypoplasia of the earlobes (HP:0009906)2.68836080
61Cervical subluxation (HP:0003308)2.68015447
62Asymmetry of the thorax (HP:0001555)2.67901080
63Spondylolisthesis (HP:0003302)2.67458893
64Abnormality of the phalanges of the hallux (HP:0010057)2.65898321
65Hepatoblastoma (HP:0002884)2.61631694
66Abnormality of the 4th metacarpal (HP:0010012)2.58060110
67Camptodactyly of toe (HP:0001836)2.57562754
68Peripheral hypomyelination (HP:0007182)2.49992250
69Overlapping toe (HP:0001845)2.46324651
70Morphological abnormality of the inner ear (HP:0011390)2.46318284
71Radial bowing (HP:0002986)2.43200079
72Thin bony cortex (HP:0002753)2.40434943
73Increased IgM level (HP:0003496)2.40056849
74Reticulocytopenia (HP:0001896)2.38925333
75Bicuspid aortic valve (HP:0001647)2.38047779
76Calcaneovalgus deformity (HP:0001848)2.37108643
77Broad distal phalanx of finger (HP:0009836)2.36390903
78Sandal gap (HP:0001852)2.36166935
79Pallor (HP:0000980)2.35659517
80Fibular hypoplasia (HP:0003038)2.32384307
81Duplicated collecting system (HP:0000081)2.32156373
82Diastasis recti (HP:0001540)2.32001164
83Blue sclerae (HP:0000592)2.31184827
84Progressive sensorineural hearing impairment (HP:0000408)2.31183543
85Wide anterior fontanel (HP:0000260)2.30656859
86Septate vagina (HP:0001153)2.30614037
87Deformed tarsal bones (HP:0008119)2.30443699
88Volvulus (HP:0002580)2.29102943
89Disproportionate tall stature (HP:0001519)2.28704798
90Cerebral aneurysm (HP:0004944)2.27102312
91Absent frontal sinuses (HP:0002688)2.25930489
92Midline defect of the nose (HP:0004122)2.25580777
93Bladder diverticulum (HP:0000015)2.25165398
94Broad phalanges of the hand (HP:0009768)2.22806702
95Acanthocytosis (HP:0001927)2.22619379
96Broad long bones (HP:0005622)2.22327077
97Abnormal lung lobation (HP:0002101)2.22155687
98Flat cornea (HP:0007720)2.21171595
99Mesomelia (HP:0003027)2.21152176
100Renal dysplasia (HP:0000110)2.20387389
101Nonimmune hydrops fetalis (HP:0001790)2.20150289
102Obsessive-compulsive behavior (HP:0000722)2.19971727
103Wormian bones (HP:0002645)2.19054464
104Aplasia/Hypoplasia of the thymus (HP:0010515)2.18577539
105Premature ovarian failure (HP:0008209)2.17862236
106Abnormality of the peritoneum (HP:0002585)2.16095273
107Tinnitus (HP:0000360)2.15672722
108Abnormally folded helix (HP:0008544)2.15275363
109Broad thumb (HP:0011304)2.15136595
110Broad phalanx (HP:0006009)2.14541409
111Myelodysplasia (HP:0002863)2.14423279
112Attention deficit hyperactivity disorder (HP:0007018)2.13426570
113Nephroblastoma (Wilms tumor) (HP:0002667)2.12686602
114Broad finger (HP:0001500)2.12407305
115Flared iliac wings (HP:0002869)2.12192910
116Shoulder girdle muscle weakness (HP:0003547)2.10505139
117Abnormality of the fingertips (HP:0001211)2.10399447
118Embryonal renal neoplasm (HP:0011794)2.09169836
119Hypoplastic left heart (HP:0004383)2.09019437
120Breech presentation (HP:0001623)2.08817484
121Hyperbilirubinemia (HP:0002904)2.06629204
122Male infertility (HP:0003251)2.06592994
123Abnormality of chromosome segregation (HP:0002916)2.06453317
124Biconcave vertebral bodies (HP:0004586)2.04901786
125Mitral valve prolapse (HP:0001634)2.04397794
126Abnormality of sulfur amino acid metabolism (HP:0004339)2.03389115
127Abnormality of the distal phalanx of the thumb (HP:0009617)2.03373555
128Follicular hyperkeratosis (HP:0007502)2.03349624
129Venous insufficiency (HP:0005293)2.03154555
130Flexion contracture of toe (HP:0005830)2.02340251
131Joint contractures involving the joints of the feet (HP:0100492)2.02340251
132Periauricular skin pits (HP:0100277)2.02291264
133Preauricular pit (HP:0004467)2.02291264
134Osteolytic defects of the phalanges of the hand (HP:0009771)2.00240682
135Osteolytic defects of the hand bones (HP:0009699)2.00240682
136Metaphyseal cupping (HP:0003021)1.99691234
137Joint laxity (HP:0001388)1.99375403
138Progressive external ophthalmoplegia (HP:0000590)1.98345702
139Abnormality of DNA repair (HP:0003254)1.97947533
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.94546763
141Mesangial abnormality (HP:0001966)1.94339436
142Long palpebral fissure (HP:0000637)1.94036235
143Selective tooth agenesis (HP:0001592)1.93771080
144Fatigue (HP:0012378)1.93165357
145Chorioretinal atrophy (HP:0000533)1.92574711
146Bowing of the arm (HP:0006488)1.92218232
147Bowed forearm bones (HP:0003956)1.92218232
148Short 5th finger (HP:0009237)1.91538392
149Abnormality of the renal collecting system (HP:0004742)1.91469623
150Rectal prolapse (HP:0002035)1.91263060
151Large hands (HP:0001176)1.90977851
152Ventricular fibrillation (HP:0001663)1.90940252
153Cheekbone underdevelopment (HP:0010669)1.90649267
154Relative macrocephaly (HP:0004482)1.90226769
155Duodenal stenosis (HP:0100867)1.89464739
156Small intestinal stenosis (HP:0012848)1.89464739
157Cafe-au-lait spot (HP:0000957)1.89128580
158Patellar dislocation (HP:0002999)1.88991821
159Tarsal synostosis (HP:0008368)1.88853085
160Elbow flexion contracture (HP:0002987)1.88658992
161Papillary thyroid carcinoma (HP:0002895)1.88585254
162Exercise-induced myalgia (HP:0003738)1.88305582
163Abnormality of chromosome stability (HP:0003220)1.87883764
164Hypoplasia of the iris (HP:0007676)1.87620339
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87178928
166Vertebral arch anomaly (HP:0008438)1.86024866
167Abnormality of the calcaneus (HP:0008364)1.85280124
168Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84451576
169Autoimmune thrombocytopenia (HP:0001973)1.84337833
170Abnormality of the acetabulum (HP:0003170)1.84167234
171Dilatation of the ascending aorta (HP:0005111)1.83427130
172Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82823994
173Synostosis involving bones of the feet (HP:0009140)1.82285599
174Synostosis involving bones of the lower limbs (HP:0009138)1.82285599
175Aplastic anemia (HP:0001915)1.81271556
17611 pairs of ribs (HP:0000878)1.80690935
177Trigonocephaly (HP:0000243)1.80093385
178Gonadotropin excess (HP:0000837)1.79666663
179Hyperextensible skin (HP:0000974)1.78759717
180Coronal craniosynostosis (HP:0004440)1.78495840
181Delayed cranial suture closure (HP:0000270)1.78394956
182Abnormality of the anterior chamber (HP:0000593)1.78019130
183Secondary amenorrhea (HP:0000869)1.77573807
184Broad palm (HP:0001169)1.77562342
185Hypoventilation (HP:0002791)1.75836547
186Inguinal hernia (HP:0000023)1.75155136
187Deviation of the hallux (HP:0010051)1.75089457
188Impaired proprioception (HP:0010831)1.74255779
189Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74093908
190Venous abnormality (HP:0002624)1.73514888
191Cutaneous finger syndactyly (HP:0010554)1.72878512
192Progressive muscle weakness (HP:0003323)1.72425223
193Increased connective tissue (HP:0009025)1.69718682
194Arteriovenous malformation (HP:0100026)1.67568009
195Long clavicles (HP:0000890)1.62533987
196Facial hemangioma (HP:0000329)1.62124001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.50150748
2KSR24.17136907
3EEF2K3.66830728
4TTK3.65841226
5MAP3K23.19561019
6PDGFRA3.11856592
7TAOK23.00728276
8CLK12.96449717
9PKN22.92598040
10TESK12.85581346
11EIF2AK12.84327059
12RAF12.71229229
13NTRK32.62872889
14RIPK42.51536508
15JAK32.44236341
16NEK92.37820914
17LATS22.24412560
18KSR12.22927942
19WEE12.20787375
20ERN12.18163267
21DDR22.17579575
22TTN2.16173266
23LATS12.15797113
24PDK42.11411161
25PDK32.11411161
26CDC72.07932957
27DMPK2.07419969
28STK32.05586257
29BRSK22.03465895
30PNCK2.02075908
31MAP3K101.96301197
32NEK11.91942176
33MYLK1.82416607
34PLK41.78483756
35TBK11.77850577
36MAP3K141.72535721
37ERBB31.71638024
38WNK11.68430250
39BMX1.63896064
40SRPK11.59729215
41PTK2B1.59428502
42PTK61.55326209
43IRAK31.54137979
44ILK1.52735715
45WNK41.51006169
46MKNK11.47442024
47PAK41.44105454
48CCNB11.42648354
49PRKD31.41491382
50TSSK61.41011455
51PDGFRB1.40544153
52CHEK21.37600267
53CHUK1.36459700
54SIK11.34249650
55BCR1.33797714
56ATR1.26276624
57LRRK21.25824998
58SCYL21.17063991
59TYK21.16845000
60CHEK11.15223358
61PASK1.15203782
62BUB11.14897113
63BRSK11.14544550
64RPS6KB21.12606531
65CAMK1G1.12138663
66PDK21.11394231
67EPHB21.11146966
68YES11.07213137
69IKBKB1.02792260
70TRPM71.01593976
71RIPK10.97835867
72LIMK10.94345280
73MET0.93908557
74FLT30.90226937
75ATM0.89801624
76NME10.88571560
77PBK0.87688458
78BMPR20.83720537
79KIT0.82741623
80NUAK10.82063629
81TGFBR20.81864621
82MAPKAPK50.81494925
83CDK10.80698119
84MAP3K50.80019639
85ICK0.79345888
86PLK10.79081905
87MAP3K10.77001913
88ABL20.76868001
89CDK20.76580039
90JAK10.75412151
91MAP3K40.74950488
92MKNK20.74355368
93BRD40.73342839
94PAK20.73116103
95CDK70.73001624
96SIK30.71885006
97TYRO30.70402131
98MAP2K60.69996839
99PRPF4B0.69713928
100PIK3CG0.67345580
101STK40.66960902
102PTK20.66287983
103FGFR10.65792324
104FER0.65665791
105RET0.65520942
106MAPKAPK20.63821492
107MARK30.63493807
108MAP3K60.61743888
109MAP3K80.61604208
110ROCK10.61546862
111ALK0.61255900
112NEK20.60225085
113ROCK20.59768114
114NLK0.59579193
115TGFBR10.59513204
116PLK30.59273548
117STK38L0.59139897
118MAP2K10.57146079
119STK390.56373104
120EIF2AK30.55222634
121PIK3CA0.54363811
122LMTK20.54050267
123FGFR30.53655227
124FRK0.53046144
125MAP3K130.52813055
126PIM20.52688430
127AKT30.52295841
128PAK30.52128472
129CDK120.49491860
130PIM10.48642146
131PAK10.47495295
132CAMK1D0.47316043
133CSNK1E0.46204686
134SGK10.45198959
135NTRK10.44893926
136FGFR40.43893074
137MAPK100.41525086
138AURKB0.40878536
139PLK20.40755311
140EIF2AK20.40015625
141RPS6KA20.39641871
142SRC0.39048845
143AKT20.38366228
144NME20.37417846
145CDK40.36425108
146CDK11A0.36369404
147JAK20.36340979
148DYRK1B0.36179913
149CSNK2A20.35961511
150MAP2K20.35783956
151RPS6KA10.34840126
152GSK3B0.33942805
153IRAK10.33154934
154PRKAA10.32529900
155RPS6KA40.32397046
156MTOR0.31357564
157MAPK140.30913304
158PRKDC0.30732412
159MAPK30.30551761
160IRAK20.30106156
161TEC0.30041389
162BRAF0.28367420
163MAPK10.26036312
164EPHA30.24765348
165INSR0.24586235
166EPHB10.23720832
167STK100.23643456

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.56565614
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.90052188
3DNA replication_Homo sapiens_hsa030303.72791981
4Allograft rejection_Homo sapiens_hsa053303.45049987
5Mismatch repair_Homo sapiens_hsa034303.34462017
6One carbon pool by folate_Homo sapiens_hsa006702.92656304
7Homologous recombination_Homo sapiens_hsa034402.89935495
8Graft-versus-host disease_Homo sapiens_hsa053322.65830231
9RNA transport_Homo sapiens_hsa030132.50910327
10Viral myocarditis_Homo sapiens_hsa054162.45714525
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.41050495
12Autoimmune thyroid disease_Homo sapiens_hsa053202.29972371
13Nucleotide excision repair_Homo sapiens_hsa034202.20773812
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07179816
15ECM-receptor interaction_Homo sapiens_hsa045122.03044926
16TNF signaling pathway_Homo sapiens_hsa046681.93371013
17Spliceosome_Homo sapiens_hsa030401.93019871
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.91936521
19TGF-beta signaling pathway_Homo sapiens_hsa043501.87825048
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86731616
21Toxoplasmosis_Homo sapiens_hsa051451.82444495
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.82383258
23Fanconi anemia pathway_Homo sapiens_hsa034601.81317113
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80819634
25Leishmaniasis_Homo sapiens_hsa051401.79132499
26Influenza A_Homo sapiens_hsa051641.78481146
27mRNA surveillance pathway_Homo sapiens_hsa030151.77202558
28Focal adhesion_Homo sapiens_hsa045101.74614279
29Biosynthesis of amino acids_Homo sapiens_hsa012301.73777392
30Shigellosis_Homo sapiens_hsa051311.72838511
31Proteoglycans in cancer_Homo sapiens_hsa052051.70863049
32Malaria_Homo sapiens_hsa051441.67288743
33Small cell lung cancer_Homo sapiens_hsa052221.65860309
34MicroRNAs in cancer_Homo sapiens_hsa052061.62238395
35Carbon metabolism_Homo sapiens_hsa012001.62179707
36Pyruvate metabolism_Homo sapiens_hsa006201.61006054
37Adherens junction_Homo sapiens_hsa045201.58103242
38Type I diabetes mellitus_Homo sapiens_hsa049401.58032777
39Chronic myeloid leukemia_Homo sapiens_hsa052201.57392566
40Amoebiasis_Homo sapiens_hsa051461.56883654
41Steroid biosynthesis_Homo sapiens_hsa001001.49728839
42Hippo signaling pathway_Homo sapiens_hsa043901.48954387
43mTOR signaling pathway_Homo sapiens_hsa041501.45068337
44Oocyte meiosis_Homo sapiens_hsa041141.40580433
45Basal transcription factors_Homo sapiens_hsa030221.40315742
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39956552
47Basal cell carcinoma_Homo sapiens_hsa052171.36809856
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35601128
49Measles_Homo sapiens_hsa051621.35252417
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34563394
51Rheumatoid arthritis_Homo sapiens_hsa053231.34295807
52Non-homologous end-joining_Homo sapiens_hsa034501.33719624
53Pentose phosphate pathway_Homo sapiens_hsa000301.33543182
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.31769149
55Herpes simplex infection_Homo sapiens_hsa051681.28803199
56Fructose and mannose metabolism_Homo sapiens_hsa000511.28172511
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27910755
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27905043
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27772936
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27429490
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.27409367
62Salmonella infection_Homo sapiens_hsa051321.24398758
63Legionellosis_Homo sapiens_hsa051341.23833996
64Osteoclast differentiation_Homo sapiens_hsa043801.21369844
65HTLV-I infection_Homo sapiens_hsa051661.20316923
66Pancreatic cancer_Homo sapiens_hsa052121.20202964
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.16732936
68ErbB signaling pathway_Homo sapiens_hsa040121.14176252
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12803272
70Hedgehog signaling pathway_Homo sapiens_hsa043401.11826582
71Dilated cardiomyopathy_Homo sapiens_hsa054141.10147793
72Apoptosis_Homo sapiens_hsa042101.08658106
73RNA degradation_Homo sapiens_hsa030181.07713560
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07459356
75Type II diabetes mellitus_Homo sapiens_hsa049301.07115728
76Pertussis_Homo sapiens_hsa051331.05545223
77Cell cycle_Homo sapiens_hsa041101.04153113
78Pathways in cancer_Homo sapiens_hsa052001.01090843
79Colorectal cancer_Homo sapiens_hsa052101.00627961
80Thyroid cancer_Homo sapiens_hsa052161.00305733
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99561221
82Tuberculosis_Homo sapiens_hsa051520.99042605
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.98382506
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97420579
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95628711
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95469733
87Prostate cancer_Homo sapiens_hsa052150.93979905
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92701173
89Prolactin signaling pathway_Homo sapiens_hsa049170.91869614
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.90007067
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89717592
92Notch signaling pathway_Homo sapiens_hsa043300.89639164
93Ribosome_Homo sapiens_hsa030100.88705956
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88002208
95Dorso-ventral axis formation_Homo sapiens_hsa043200.87565698
96Sulfur relay system_Homo sapiens_hsa041220.87400205
97Hepatitis B_Homo sapiens_hsa051610.87330616
98Protein digestion and absorption_Homo sapiens_hsa049740.87328468
99Renin-angiotensin system_Homo sapiens_hsa046140.87320802
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86395971
101Chemokine signaling pathway_Homo sapiens_hsa040620.86065084
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84932162
103Insulin signaling pathway_Homo sapiens_hsa049100.83693263
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.82788291
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81673177
106Prion diseases_Homo sapiens_hsa050200.81204967
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79382764
108Lysine degradation_Homo sapiens_hsa003100.77258380
109Phagosome_Homo sapiens_hsa041450.76630658
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76506330
111Arginine biosynthesis_Homo sapiens_hsa002200.75020447
112Olfactory transduction_Homo sapiens_hsa047400.74692775
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.74277557
114p53 signaling pathway_Homo sapiens_hsa041150.73578583
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.72530674
116Selenocompound metabolism_Homo sapiens_hsa004500.70554302
117Viral carcinogenesis_Homo sapiens_hsa052030.70049921
118African trypanosomiasis_Homo sapiens_hsa051430.68916102
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67571753
120Endometrial cancer_Homo sapiens_hsa052130.65934317
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65410902
122Glioma_Homo sapiens_hsa052140.62777225
123Staphylococcus aureus infection_Homo sapiens_hsa051500.62049395
124Melanoma_Homo sapiens_hsa052180.59097079
125Acute myeloid leukemia_Homo sapiens_hsa052210.57832966
126Pyrimidine metabolism_Homo sapiens_hsa002400.56891442
127Choline metabolism in cancer_Homo sapiens_hsa052310.56407037
128Axon guidance_Homo sapiens_hsa043600.56031797
129Antigen processing and presentation_Homo sapiens_hsa046120.55303128
130Epstein-Barr virus infection_Homo sapiens_hsa051690.55080599
131Purine metabolism_Homo sapiens_hsa002300.54752741
132Bladder cancer_Homo sapiens_hsa052190.53271026
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52783154
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52603293
135Rap1 signaling pathway_Homo sapiens_hsa040150.52524324
136Wnt signaling pathway_Homo sapiens_hsa043100.51948648
137Renal cell carcinoma_Homo sapiens_hsa052110.51674251
138Asthma_Homo sapiens_hsa053100.51650866
139Propanoate metabolism_Homo sapiens_hsa006400.50761905
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49519655
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49093716
142Tight junction_Homo sapiens_hsa045300.48810246
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48752478
144B cell receptor signaling pathway_Homo sapiens_hsa046620.46500413
145Base excision repair_Homo sapiens_hsa034100.46222509
146Fatty acid metabolism_Homo sapiens_hsa012120.45872159
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45452308
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45429437
149VEGF signaling pathway_Homo sapiens_hsa043700.44581011
150HIF-1 signaling pathway_Homo sapiens_hsa040660.43591083
151Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42549552
152AMPK signaling pathway_Homo sapiens_hsa041520.42467854
153Other glycan degradation_Homo sapiens_hsa005110.42371251
154Non-small cell lung cancer_Homo sapiens_hsa052230.41775563
155Platelet activation_Homo sapiens_hsa046110.41286106
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39418220
157N-Glycan biosynthesis_Homo sapiens_hsa005100.39300377
158Fatty acid biosynthesis_Homo sapiens_hsa000610.36498241
159Galactose metabolism_Homo sapiens_hsa000520.35456637
160Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35287212
161RNA polymerase_Homo sapiens_hsa030200.29720309
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29234593
163Inositol phosphate metabolism_Homo sapiens_hsa005620.25693422
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.24022334
165Long-term potentiation_Homo sapiens_hsa047200.20445256
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20286136
167SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19416114

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